Translating discovery science into improved health through technological innovation

An Integrated Life Sciences Campus

UHB QE Hospital

Institute of Biomedical Research

CRUK Cancer Centre

NIHR-WT CRF

Centre for Translational Inflammation Research

Advanced Therapy Facility

Medical School

University of Birmingham

Institute Translational MedicineRoyal Centre Defence MedicineTrauma Research Centre

Public Health ResearchPrimary Care

Future location Children’s Hospital

DISCOVERY SCIENCE

CLINICALTRIALS

CLINICAL OBSERVATIONS

EXPERIMENTALMEDICINE

EFFECTIVENESS

HEALTH ECONOMICS

IMPLEMENTATION

WM AHSNPATIENT &

POPULATION HEALTH

BHP

AdoptionEducationClinical TrialsDigital TechnologyWealth CreationIntegrated Care

IBR

NIHR WT CRF

CRC TUBCTUPCTU

CLAHRC

PATIENT & PUBLIC INVOLVEMENT

Focussed Research Strategy with World Leading Outputs

SURGERY, DEVICES, DIAGNOSTICS

CLINICAL TRIALS

STRATIFIED MEDICINE

ENABLING TECHNOLOGIES

EDUCATION

COMMERCIALISATION

ENDOCRINOLOGY & METABOLISM

CLINICAL ACADEMIC GROUPS

SCIENTIFIC DISCOVERY

PATIENTBENEFIT

REGIONALDEVELOPMENT

GLOBAL IMPACT

CANCER

CHRONIC INFLAMMATORY

DISEASE

Translational Research Underpinned by Nationally Funded Centres

ARUK RA CENTRE of

EXCELLENCE

MRC-ARUK CENTRE M-S

AGEING

NIHR BRU LIVER

DISEASE

MRC CENTRE IMMUNE

REGULATION

CRUK CANCER CENTRE

CRUK TRIALS UNIT

ECMC EXPERIMENTAL

CANCER CENTRE

NIHR TRAUMA CENTRE

HEALING FOUNDATION CENTRE FOR

BURNS

NIHR TRC RARE

DISEASES

LLR CENTRE CLINICAL

HEMATOLOGY TAP

ARUKBEAT RA

NIHR TRC ENDOCRINE NEOPLASIA

NIHR TRAUMA HTC

NIHR TRP Joint and

Inflammatory Disease

Endocrine & Metabolism

CRUK Technology

Hub

EPSRC Multidisciplinary Assessment of

Technology Centre for Healthcare (MATCH)

NICE External Assessment

Centre

ERDF Biomedical

Innovation Hub

NIHR Wellcome Trust CRF

NIHR CLAHRC WM

Chronic Inflammation Cancer

Digital Technology Supports Excellence in Care

RESEARCH

CLINICAL AUDIT

SERVICE IMPROVEMENT EDUCATION

Research Advances Embedded in Education and Training to all Health Workers

• Clinical academic training– Inspire student programme– Royal College of Surgeons trainee programme– Clinical fellows embedded in NIHRWT CRF

• New models– Empowering NHS Consultants to deliver research

• Multidisciplinary – Allied Health Professionals– Common CPD, CME, e-learning platforms across BHP– Centre for Research in Medical & Dental Education

• UK Government £12m• BHP £12m• To open June 2015

A UNIQUE TRANSLATIONAL FACILITY WITH STRATIFIED MEDICINE AT ITS CORE

The Institute of Translational Medicine (ITM)- co-locating all components of an effective

translational infrastructure

TRP’s

MRC-ABPI InflammationBiology

CRFIRF

MRC Centre for ImmuneRegulationCentre for Translational Inflammation Research

SSfH

MRC CentreTheme 3

ARUK-MRCAgeing

EATCBEAT-RA

Inflammation research in Birmingham

The Birmingham Inflammation Group

Joint

Skin

LungBraine.g. MS

Liver

Teeth

Joint

Lung

CVS

Kidney

Liver

ProcessDriven

Pathology

Eye

Current SituationIn Chronic Inflammation

•Fragmentation•Duplication•Disease specific funding•Short term•Diagnosis to pathology

Birmingham Inflammation Group

•Integration•Multidisciplinary•Process specific funding•Durability•Pathology to Diagnosis

Inflammation Research Facility

Joint

Skin

LungBraine.g. MS

Liver

Teeth

Joint

Lung

CVS

Kidney

Liver

SharedCohortsAnd IT

(co-morbidity)

Eye

Current SituationIn Chronic Inflammation

•Primary-secondary care split•No core data set•No information on co-morbidity•Lack of real world data

IRF(supported by WT CRF)

•Integration across 1ry and 2ry•Core data set•Respiratory, CVS, metabolic, periodontal•Within NHS Research Clinics

• Unique stromal expertise• Highly focused basic science and expanding early

arthritiscohorts

• Direct access to patient tissue samples• Discrete stromal target discovery programmes• Multiple pre-clinical animal models• Internal and Industry therapeutic candidates

cohort samples target discover

y

Markers

Epigenetics

SSFH

validation

Protein expression

pre-clinical studies

cohort: therap

y

In vitro function

Experimental Arthritis in Birmingham

Periodontal

Operational PartnershipUHBFT Queen Elizabeth Hospital Centre for Translational Inflammation Integrated clinical and laboratory space ARUK/MRC CoE in MSK ageing researchWTCRF satellite (IRF) ARUK EATC (BEAT-RA)NIHR Trauma Centre Translational Research Partnership

ARUK CoE in Pathogenesis of RA

UK wide strategy• Reduce bureaucracy• £310m for stratified medicine

and commercial research• Opt out for research data• Encourage industry

engagement• Stimulate economic growth

Strategy for UK Life Sciences