Waccbip Presentation - Health - Cotonou

4TH WORLD BANK ACE WORKSHOP

Sika MenkaSika Menka

((Monitoring & Evaluation OfficerMonitoring & Evaluation Officer))

West African Centre for Cell Biology of Infectious Pathogens

CENTRE TEAM

•Dr. Gordon A. Awandare - Director

•Prof. Kwadwo A. Koram - Deputy Director

•Dr. Olukemi Amodu - Representative of regional partners

•Mr. Collins Amofah - Finance Focal Person

•Ms. Sika Menka - Monitoring and Evaluation Focal Person

•Mrs. Constance Kocke - Procurement Focal Person

MISSION OF WACCBIP

o The mission of WACCIP is to:Improve diagnosis, prevention and control of infectious diseases in sub-Saharan Africa by providing advanced level training and research excellence on the cell and molecular biology of infectious pathogens.

AWARDS AND ACHIEVEMENTS

o WACCBIP- Wellcome Trust DELTAS Africa Initiative• The centre will receive £ 5.1 million over 5 years for human genetics

training of 15 PhDs and 12 Postdoctoral fellows

o Grants awarded to students• Noguchi Graduate Research Scheme – 6 MPhil students awarded

• DANIDA-Malaria Vaccine Research and Capacity building in Ghana – full scholarships for 4 PhD Students

• 2 Royal Society/Leverhulme Grants – scholarships for 2 PhD students• AIMS – scholarship for 1 PhD student• Building Strong Universities (BSU) II project - scholarships for 2 PhD

students

Program Activities and their Disbursement Linked Indicators

o DLI 2.1- Short courses launched• 1st Workshop on Molecular Biology, Pathogenesis and Diagnostics of

Neglected diseases (July, 2014)

Topics Number of students

• Successful diagnostics in use today• Careers in Science in Ghana • Understanding trypanosomes• Investigating human rotavirus

Erythrocyte invasion mechanisms used by Plasmodium falciparum

• Science funding

10 Students

(4 females, 6 males, 0 regional)


o DLI 2.1- Short courses launched• 2nd Workshop on Molecular Biology, Pathogenesis and Diagnostics of

Neglected diseases (July, 2015)

Topics Number of students

• Introduction to advance diagnostic tools in the control and treatment infectious diseases

• Career opportunities in Science• Bioinformatics and sequence

analysis• Molecular basis for host-pathogen

interactions• Recombinant protein production• Grantsmanship

15 students

(7 females, 8 males, 3 regional)


o Short courses planned for next year

• WACCBIP-American Society of Cell Biology workshop (January 18 - 29, 2016)

• 3rd Workshop on Molecular Biology, Pathogenesis and Diagnostics of Neglected diseases (July 4 -15, 2016)


o DLI 2.2- New Masters programme

1st Cohort: 30 students (7 female, 23 male, 4 regional)

• MSc Biochemistry - 6 students

• MPhil Biochemistry- 2 student

• MPhil Molecular Biology – 2 students

• MPhil Molecular Cell Biology of Infectious Diseases (MCBI) - 20 students


o DLI 2.2- New Masters programme

2nd Cohort, 22 students (9 female, 13 male, 0 regional)• MSc Biochemistry – 1 student• MPhil Biochemistry - 2 students• MPhil Molecular Biology - 3 students• MPhil Molecular Cell Biology of Infectious Diseases (MCBI) - 16 students


o DLI 2.3- New PhD Programmme • PhD Biochemistry• PhD Molecular Cell Biology of Infectious Diseases (MCBI)

-1st cohort: 15 students; 7 females, 8 males, 0 regional

- 2nd cohorts:13 students; 5 females, 8 males, 2 regional


• DLI 2.4 - Outreach Periods/ Internships Faculty internships – 5 (1 female, 4 male, 1 regional)

Cambridge CAPREx Programme

WACCBIP

Student internship - 6 (6 female, 0 male, 0 regional)

London School of Hygiene and Tropical Medicine, UK

University of Cambridge, UK

Novartis, Switzerland

University of Copenhagen, UK

Pasteur Institute, France


o DLI 2.5- Accreditation

• National Accreditationo New programmes (MPhil MCBI and PhD MCBI) assessed and

accredited by National Accreditation Board

• International reviews and Accreditationo The ITC of ASCB reviewed and advised on all new curriculao Visit by the Society of Biology, UK later this year subject to

availability of funds


o DLI 2.6- Published Articles

• 38 internationally recognized publications accrued between March, 2014 - August, 2015 by WACCBIP faculty

• 4 publications co-authored with regional partners.


o Publications co-authored with regional partners.

1. Narh, C. A., Mosi, L., Quaye, C., Dassi, C., Konan, D. O., Tay, S. C. K., de Souza, D. K., Boakye, D. A., & Bonfoh, B. (2015). Source Tracking Mycobacterium ulcerans Infections in the Ashanti Region, Ghana. PLoS Neglected Tropical Diseases, 9(1):18

2. Bowyer, P. W., Stewart, L. B., Aspeling-Jones, H., Mensah-Brown, H. E., Ahouidi, A. D., Amambua-Ngwa, A., Awandare, G. A., & Conway, D. J. (2015). Variation in Plasmodium falciparum Erythrocyte Invasion Phenotypes and Merozoite Ligand Gene Expression across Different Populations in Areas of Malaria Endemicity. Infection and Immunity, 83(6):2575-82

3. Narh, C. A., Mosi, L., Quaye, C., Tay, S. C. K., Bonfoh, B., & de Souza, D. K. (2014). Genotyping tools for Mycobacterium ulcerans- drawbacks and future prospect. Mycobacterial Diseases, 4(2)

4. Ghansah, A., Amenga-Etego, L., Amambua-Ngwa, A., et al. (2014). Monitoring parasite diversity for malaria elimination in sub-Saharan Africa. Science, 345(6202), 1297-1298


o Internationally recognized publications by WACCBIP faculty1. Asante-Poku, A., Otchere, I.D., Danso, E., Mensah, D.D., Bonsu, F., Gagneux, S., &

Yeboah-Manu, D. (2015). Evaluation of GenoTypeW MTBDR plus for the rapid detection of drug-resistant tuberculosis in Ghana. International Journal of Tuberculosis and Lung Disease. 19(8):954-959

2. Tsouh, P. V. F., Addo, P., Yeboah-Manu, D., & Boyom, F. F. (2015). Methods used in preclinical assessment of anti-Buruli ulcer agents: A global perspective. Journal of Pharmacological and Toxicological Methods. 73:27-33

3. Nguta, J. M., Appiah-Opong, R., Nyarko, A. K., Yeboah-Manu, D., Addo, P. G. A. (2015). Medicinal plants used to treat TB in Ghana. International Journal of Mycobacteriology. 4(2):116-123

4. Badu, K., Gyan, B., Appawu, M., Mensah, D., Dodoo, D., Yan, G., Drakeley, C., Zhou, G., Owusu-Dabo, E., & Koram, K. A. (2015). Serological evidence of vector and parasite exposure in Southern Ghana: The dynamics of malaria transmission intensity. Parasites and Vectors. 8(1), 861


5. Duffy, C. W., Assefa, S. A., MacInnis, B., Abugri, J., Amoako, N., Owusu-Agyei, S., Anyorigiya, T., Kwiatkowski, D. P., Conway, D. J. & Awandare, G. A. (2015). Comparison of genomic signatures of selection on Plasmodium falciparum between different regions of a country with high malaria endemicity. BMC Genomics, 16:527

6. Adjimani, J. P. & Asare, P. (2015). Antioxidant and free radical scavenging activity of iron chelators. Toxicology reports, 721-728

7. Anum, D., Kusi, K. A., Ofori, M. F., Koram, K. A.,, Dodoo, D., et al. (2015). Measuring naturally acquired ex vivo IFN-γ responses to Plasmodium falciparum Cell-traversal protein for ookinetes and sporozoites (CelTOS) in Ghanaian adults. Malaria Journal, 14(20)

8. Hori, T., Koram, K., Nyarko, A., Okine L., Edoh, D., et al. (2015). Procyanidin trimer C1 derived from Theobroma cacao reactivates latent human immunodeficiency virus type 1 provirus. Biochemical and Biophysical Research Communications, 459(2):288-93

9. Mensah-Brown, H. E., Amoako, N., Abugri, J., Conway, D. J., Awandare, G. A., et al. (2015). Analysis of erythrocyte invasion mechanisms of Plasmodium falciparum clinical isolates across three endemic areas within one country. The Journal of Infectious Diseases, pii: jiv207.


10. Stoler, J., Delimini, R. K., Bonney, K. J.H., Oduro, A. R., Owusu-Agyei, S., Fobil, J. N., & Awandare, G. A. (2015). Evidence of recent Dengue exposure among malaria parasite-positive children in three urban centers in Ghana. The American Journal of Tropical Medicine and Hygiene, 92(3), 497-500

11. Asante-Poku, A., Yeboah-Manu, D., Otchere, I. D., et al. (2015). Mycobacterium africanum is associated with patient ethnicity in Ghana. PLoS Neglected Tropical Disease, 9(1):e3370

12. Ocloo, A., Appiah Opong, R, Chama, M. A., et al. (2015). An In Situ Study on the ‐Effects of Extracts of Taraxacum Officinale, Paulliniia Pinnata and Thonningia Sanguinea on Mitochondrial Function. Journal of Food Biochemistry 39(1):55-63

13. Suzuki, M., Koram, K., Ohta, N., Boakye, D. A., et al. (2015). New anti-trypanosomal active tetracyclic iridoid isolated from morinda lucida benth. Bioorganic and Medicinal Chemistry Letters, 25(15), 3030-3033. doi:10.1016/j.bmcl.2015.05.003

14. Asiedu-Larbi, J., Adjimani, J. P., Okine, L. K. N., Addy, M. E., et al. (2014). Efficacy studies on Mist Diodia, a herbal preparation for the management of hypertension in rodents. Medicinal & Aromatic Plant Research Journal, 2(1), 6-17.


15. Amoako, N., Asante, K. P., Adjei, G., Awandare, G. A., et al. (2014). Associations between Red Cell Polymorphisms and Plasmodium falciparum Infection in the Middle Belt of Ghana. PLoS One, 9(12)

16. Bratschi, M. W., Bolz, M., Yeboah-Manu, D., Ruf, M. T., Pluschke, G. et al. (2014). Primary cultivation: factors affecting contamination and Mycobacterium ulcerans growth after long turnover time of clinical specimens. BMC Infectious Diseases,14(1):636

17. Abuaku, B., Quaye, L., Duah, N., Quashie, N., & Koram, K. (2014). Managing antimalarial drug resistance in Ghana: The importance of surveillance, Towards Effective Disease Control in Ghana: Research and policy implications (Clinical Science series No. 5-1). Sub-Saharan publishers. ISBN: 978-9988-647-50-6

18. Adu, B., Jepsen, M. P., Gerds, T. A., Kyei-Baafour, E., Christiansen, M., Dodoo, D., & Theisen, M. (2014). Fc gamma receptor 3B (FCGR3B-c.233C>A-rs5030738) polymorphism modifies the protective effect of malaria specific antibodies in Ghanaian children. The Journal of Infectious Diseases, 209(2), 285-9

19. Ampomah, P., Stevenson, L., Ofori, M. F., et al. (2014). Kinetics of B Cell Responses to Plasmodium falciparum Erythrocyte Membrane Protein 1 in Ghanaian Women Naturally Exposed to Malaria Parasites. The Journal of Immunology, 192(11), 5236-44


20. Asante-Poku, A., Aning, K. G., Boi-Kikimoto, B., & Yeboah- Manu, D., (2014). Prevalence of bovine tuberculosis in a dairy cattle farm and a research farm in Ghana, Onderstepoort Journal of Veterinary Research, 81(2): 716-21

21. Asante-Poku, M., Nyaho, S., Borrell, S., Comas, I., Gagneux, S., & Yeboah-Manu, D. (2014). Evaluation of customised lineage-specific sets of MIRU-VNTR loci for genotyping Mycobacterium tuberculosis complex isolates in Ghana. PloS One, 9(3), e92675.

22. Asare, K. K., Boampong, J. N., Afoakwah, R., Ameyaw, E. O., Sehgal, R., & Quashie, N. B. (2014). Use of Proscribed Chloroquine is associated with an increased risk of Pfcrt T76 mutation in some parts of Ghana. Malaria Journal, 13(246).

23. Asare, K. K., Boampong, J. N., Ameyaw, E. O., Thomford, A. K., Afoakwah, R., Kwakye-Nuako, G., Thomford, K. P., & Quashie, N. B. (2014). Microscopic identification of possible Clonorchiasis/ Opisthorchiasis Infection in Two Ghanaian Women with an Undiagnosed Abdominal Discomfort: Two Case Report. Journal of Medical Case Reports, 8(369).

24. Awodele, O., Tomoye, O. P., Quashie, N. B., et al. (2014). Gentamicin Nephrotoxicity: Animal Experimental Correlate with Human Pharmacovigilance Outcome. Biomedical Journal, doi: 10.4103/2319-4170.131387.


25. Donkor, K., Antwi, S., Asiedu-Larbi, J., Takyi, N., & Okine, L. K. (2014). Sub-chronic toxicity studies of Asena, a poly-herbal formulation for the treatment of arthritis in rat. Medicinal and Aromatic Plants Research Journal, 2(1), 18-27.

26. Greenwood, B., & Koram, K. A. (2014). Malaria control in Africa: progress but still much to do. Lancet, 383(9930), 1703-4.

27. Kusi, K. A., Bosomprah, S., Dodoo, D., Kyei-Baafour, E., Dickson, E. K., Mensah, D., Angov, E., Dutta, S., Sedegah, M., & Koram, K. A. (2014). Anti-sporozoite antibodies as alternative markers for malaria transmission intensity estimation. Malaria journal, 13(1), 103.

28. Ocloo, A., Okpattah, W. E., Quasie, O., Sakyiamah, M. M., & Okine, L. K. N. (2014). Concurrent administration of aqueous Extract of Cryptolepis sanguinolenta reduces the effectiveness of Artesunate against Plasmodium berghei in Rats. Journal of Applied Pharmaceutical Science, 4(3), 024-028.

29. Williamson, H. R., Aqqad, M., Donnell, R., Mosi, L., Merritt, R. W., & Small, P. L. C. (2014). Laboratory Studies on the ability of Mycobacterium ulcerans to infect through open wounds. PLoS Neglected Tropical Disease, 8(4), e2770


30. Röltgen, K., Bratschi, M. W., Ross, A., Aboagye, S. Y., Ampah, K. A., Bolz, M., Andreoli, A., Pritchard, J., Minyem, J. C., Noumen, D., Koka, E., Um Boock, A., Yeboah-Manu, D., & Pluschke, G. (2014). Late onset of the serological response against the 18 kDa small heat shock protein of Mycobacterium ulcerans in children. PLoS Neglected Tropical Disease, 8(5), e2904

31. Sanuade, O. A., Anarfi, J. K., Aikins, Ad., & Koram, K. A. (2014). Patterns of cardiovascular disease mortality in Ghana: a 5-year review of autopsy cases at Korle-Bu Teaching Hospital. Ethnicity and Diseases, Winter, 24(1), 55-9

32. Stoler, J., al Dashti, R. A., Anto, F., Fobil, J. N., & Awandare, G. A. (2014). Deconstructing "malaria": West Africa as the next front for dengue fever surveillance and control. Acta Tropica, 134(1), 58 - 65

33. Tettey, C. O., Ocloo, A., Nagajyothi, P. C. N., & Lee, K. D. (2014). Anti-proliferative and Anti-microbial Activities of Taraxacum officinale (Dandelion) Leaf Extracts. Journal of Applied Pharmaceutical Science, 4(3), 041-045

34. Tettey, C. O., Ocloo, A., Nagajyothi, P. C. N., & Lee, K. D. (2014). Antioxidant activity, of solvent-fractionated Taraxacum officinale (dandelion) Leaves. Journal of Herbs, Spices and Medicinal Plants, 20(4), 329-340


o DLI 2.7- Revenue Generated

o The centre has been contracted to provide educational services in the areas of health to The Gambia Republic under the World Bank ACE Project

• Under this arrangement, the centre is expected to will generate a total

$ 214,00.00 for the training of:

- 2 PhDs= $ 146,000.00

- 2 Masters= $ 68,000.00

o WACCBIP- Wellcome Trust DELTAS Africa Initiative• The centre will receive £ 5.1 million over 5 years for human genetics

training of 15 PhDs and 12 Postdoctoral fellows• First disbursement of $934,098 received


o DLI 2.8 - Milestones for Education & Research Environment

• Begin construction of the new building including graduate lecture rooms, seminar room, bioinformatics lab

• 60% completion of the building facility completed• Establishment of research core facility• 100% completion of the building facility


o Milestone Progress

• Establishment of research core facility

- Opened tender and procured a flow cytometer. Awaiting delivery and

installation of equipment

• Begin construction of the new building including graduate lecture rooms, seminar room, bioinformatics lab

- Requested tender opening for selecting a contractor for the building

First Disbursement Expenditure

First Disbursement: $728,838.20

Academic quality • Student Scholarships: 20 Masters and 24 PhDs (Tuition fees, research costs, stipend)

• Partner Institutions

$ 130,000

$ 35,000

Establishment of research core facility

• Flow cytometer• Bench top centrifuge (2)• Biosafety cabinets (2)

$ 332,200$ 40,000$ 26,800

Centre management • Administrative and staff costs• Vehicle• Travel• Travel cost owed to UG

$ 20,000$110,000$ 15,000$ 50,000

TOTAL $ 759,000

BALANCE - $ 30, 171.80

Program Challenges

o Top 3 challenges to program include:

• Recruitment of foreign/regional students • Industry partnership development• Challenges associated with importing laboratory supplies and

consumables for research

Program Management Challenges

o Top 2 program management/operations challenges include:

• Delays in disbursement of funds• Bureaucratic procurement processes

Top Goal/Hope for the next year

• Generate more revenue through:

-Training/teaching contracts

- Laboratory supply store

- Private sector engagement (consultancy and

sponsorship)

• Core research facility and e-learning platform should be established

• Increment in regional and female student numbers• International accreditation from SoB, UK• Embark on outreach programmes

Thank You