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STEVEN J. CZINN, M.D.Professor, Tenured

Department of PediatricsUniversity of Maryland School of Medicine

DATE: May 25, 2007

PERSONAL INFORMATION:22 S. Greene Street – N5E17Baltimore, Maryland, 21201410-328-6777 [email protected]

EDUCATION:

1979 M.D.Case Western Reserve University School of MedicineCleveland, Ohio

1975 B.S. (Magna Cum Laude) Case Western Reserve University Cleveland, Ohio

POST GRADUATE EDUCATION & TRAINING:

1982-1985 FellowshipPediatric Gastroenterology Rainbow Babies & Children’s Hospital Case Western Reserve University School of MedicineDepartment of Pediatrics Cleveland, Ohio

1980-1982 ResidencyRainbow Babies & Children’s Hospital Case Western Reserve University School of MedicineDepartment of Pediatrics Cleveland, Ohio

mailto:[email protected]

SJ Czinn, Curriculum Vitae, p. 2

1979-1980 InternshipRainbow Babies & Children’s Hospital Case Western Reserve University School of MedicineDepartment of Pediatrics Cleveland, Ohio

BOARD CERTIFICATIONS:1980 Diplomate National Board of Medical Examiners1985 Diplomate American Board of Pediatrics1990; 1997 Pediatric Gastroenterology

MEDICAL LICENSURE:2005/Current D64067 Maryland 1982 Ohio

EMPLOYMENT HISTORYMarch 2006 -Present University of Maryland School of Medicine

Department of Pediatircs

1985 – March 2006 Case Western Reserve UniversitySchool of MedicineDepartments of Pediatrics & Pathology Cleveland, Ohio

FACULTY APPOINTMENTS:March 2006 – Present Professor with tenure

University of Maryland School of MedicineChair, Department of Pediatrics

1999-present Professor, with tenureCase Western Reserve UniversitySchool of MedicineDepartments of Pediatrics & Pathology Cleveland, Ohio

1993-1999 Awarded tenure as Associate Professor Case Western Reserve UniversitySchool of MedicineDepartment of PediatricsCleveland, Ohio


1991-1993 Associate ProfessorCase Western Reserve UniversitySchool of MedicineDepartment of PediatricsCleveland, Ohio

1985-1991 Assistant ProfessorCase Western Reserve UniversitySchool of MedicineDepartment of PediatricsCleveland, Ohio

1984-1985 InstructorRainbow Babies & Children’s HospitalCase Western Reserve UniversitySchool of MedicineDepartment of PediatricsCleveland, Ohio

CLINICAL/ADMINISTRATIVE APPOINTMENTS:

March 2006 – Present Clinical ChiefDepartment of PediatricsUniversity of Maryland Medical SystemBaltimore, Maryland

1998- March 2006 Chief, Division of Pediatric Gastroenterology and NutritionRainbow Babies & Children’s HospitalDepartment of PediatricsCleveland, Ohio

1998-2000 Co-Director, Undergraduate Summer Research ProgramRainbow Babies & Children’s HospitalDepartment of PediatricsCleveland, Ohio

1997-2000 Pediatric Faculty CoordinatorUH/VAMC third year Primary Care Track ProgramRainbow Babies & Children’s HospitalDepartment of PediatricsCleveland, Ohio

1992-1999 Director, Pediatric Core ClerkshipRainbow Babies & Children’s HospitalDepartment of PediatricsCleveland, Ohio


1991-1999 Associate PediatricianRainbow Babies & Children’s HospitalDepartment of PediatricsCleveland, Ohio

1986-1990 Director, Special Procedures LaboratoryRainbow Babies & Children’s HospitalDepartment of PediatricsCleveland, Ohio

1986-1987 Acting ChiefDivision of Pediatric GastroenterologyRainbow Babies & Children’s HospitalDepartment of PediatricsCleveland, Ohio

1985-1991 Assistant PediatricianRainbow Babies & Children’s HospitalDepartment of PediatricsCleveland, Ohio

PROFESSIONAL SOCIETY MEMBERSHIPS:

Society for Pediatric ResearchAmerican Gastroenterological AssociationNorth American Society for Pediatric GastroenterologySociety of Mucosal ImmunologyMidwest Gut ClubAmerican Academy of Pediatrics (fellow)Northern Ohio Pediatric SocietyAmerican Society of MicrobiologyAmerican College of Gastroenterology (fellow)

ADMINISTRATIVE SERVICE:

Department/Hospital Committees-University of Maryland Medical Center School of Medicine/University of Maryland Hospital for Children2007- Leadership Research Planning, Subcommittee2007- Mount Washington Pediatrics Hospital Transition Team, Chairman2007- Program in Genetics and Genomic Medicine Executive Committee2007- UMMC Strategic Planning Steering Committee2006- Clinical Affairs Advisory Committee2006 Search Committee, Department of Medicine2006- School of Medicine Council Executive Committee2006- UMMC Medical Executive Committee2006- University Physicians Incorporated Board of Trustees


2006 LCME Self-Study Task Force

Department/Hospital Committees- Case Western Reserve University School of Medicine/Rainbow Babies & Children's Hospital2000-2006 Promotions and Tenure Committee, Department of Pediatrics 1998-2006 Academic Planning Committee, Department of Pediatrics 1997-2006 Primary Care Track Program: UH representative in Pediatrics1992-2006 Education Committee, Department of Pediatrics 1992-1994 Contracting Committee, Department of Pediatrics 1990-1991 Infant Formula Direct Advertising Committee, Department of Pediatrics 1990-2006 Research Committee, Department of Pediatrics 1989-1991 Intensive Care Unit/Subspecialty Task Force, Department of Pediatrics 1988-1993 Pediatric Gastroenterology Quality Assurance Program 1988-1992 University Hospitals Gastrointestinal Drug Specialty Panel 1986-1987 Rainbow Ambulatory/Subspecialty Utilization Committee 1985-1986 Intern Selection Committee, Department of Pediatrics

National/International Service:

Committee Appointments:

2004-present ChairmanNorth American Society for Pediatric Gastroenterology Hepatology and NutritionResearch Committee

2004-present Children’s Digestive Health FoundationScientific Advisory Board

1998-present MemberEuropean Helicobacter Pylori Study GroupPediatric Task Force

1998, 2004 MemberCanadian Helicobacter Pylori Study GroupPediatric Consensus Group

1998-2002 MemberCenter for Disease ControlHelicobacter pylori Pediatric Surveillance Laboratory

1998-present MemberNorth American Society for Pediatric Gastroenterology Hepatology and NutritionHelicobacter Pylori Working Group

2002-2005 Children’s Digestive Health FoundationChairman: Pediatric GERD Newsletter Committee


1997-1999 ChairmanAmerican Gastroenterology AssociationAbstract review committee for H. pylori pathogenesis

1995-2004 MemberAmerican Gastroenterology Association Abstract review committee for H. pylori pathogenesis

1991-1995 MemberStandardization CommitteeHelicobacter Pylori Susceptibility Testing

1990-1992 MemberNorth American Society for Pediatric GastroenterologyResearch Committee

Grant Reviewer:

1997 Ad hoc ReviewerNIH/Comparative Medicine – Special Study Section

1993-present Ad hoc ReviewerNIH/Bacteriology and Mycology 1 study section

1992-1993 Ad hoc ReviewerNational Research Council: Cooperative Research Program

1991 Ad hoc ReviewerNational Cancer Institute

1990 NIH Site Visit, “Helicobacter pylori and Gastric Cancer”Tulane University

1990-1992 External ReviewerThrasher Foundation

Editorial Activities:

2003-present Associate Editor: American Journal of Gastroenterology

2004-present Associate Editor: International Seminars in Pediatric Gastroenterology and Nutrition

1998 EditorCurrent Topics in Microbiology and Immunology


“Gastroduodenal Disease and Helicobacter pylori: Pathophysiology, Diagnosis and Treatment.” Eds. U. Westblom S. Czinn J. Nedrud. Springer Verlag

1997-present Editorial Board MemberJournal of Pediatric Gastroenterology and Nutrition

1996-present Editorial Board MemberInfection & Immunity

1995-present Editorial Board MemberHelicobacter

Journal Reviewer:

Infection and ImmunityScienceJournal of ImmunologyGastroenterologyJournal of PediatricsPediatricsJournal of Pediatric Gastroenterology and NutritionEuropean Journal of Clinical MicrobiologyAntimicrobial Agents and ChemotherapyDigestive Diseases and SciencesPediatric Infectious DiseaseHelicobacterJournal of PediatricsGUT

Consultant Activities:

OraVaxAstra/MerckGlaxoTap PharmaceuticalsProcter & GambleUlysses Group

TEACHING SERVICE:

Medical Student Teaching:

1989- March 2006 Attending Physician – Pediatric Gastroenterology (3 months/year)Daily teaching rounds12 hours/week - 3 studentsInformal rounds


14 hours/week - 3-4 students/month

1990-2001 Presenter/OrganizerPediatric GI Journal/Research Meeting1 hour/week – 2-3 students/fellows

1989-2001 PreceptorGI Clinic or Endoscopy Suite 4 hours/week – 1 fellow

1992-1999 Core Clerkship Director, Department of PediatricsSupervision and teaching of medical students in Core Clerkship10 hours/week - 12 students/month

1997-2000 Primary Care Track – UH Representative in Pediatrics3rd year Primary Care Track ClerkshipOrganized the pediatric component of this clerkshipMember, Year 4-7 Oversight Committee

1997 Lecturer - Biological Basis of Disease (BBD-1)Lecture on Mucosal Immunology1 hour / 120 Students

1989-2002 Small Group LeaderBiological Basis of Disease (BBD-1)6 hours / 12 Students

Resident/Fellow Teaching:1989- 2006 Attending Physician – Pediatric Gastroenterology (3 months/year)

Daily teaching rounds12 hours/week – 4 residentsInformal rounds14 hours/week (3-4 residents/month)

Graduate Student Teaching:1997- March 2006 Thesis co-advisor for Chris Garhart

Department of Pathology

1993 – 1996 Thesis co-advisor for Marjan MohammadiDepartment of Pathology(Currently holds faculty appointment in Iran)

Undergraduate Teaching:1998-2000 Co-Director

Department of Pediatrics – Undergraduate Summer Research ProgramSupervise and meet with students weekly.100 hours/12 students


GRANTS & CONTRACTS:

Federal Grants:

12/1/02-11/30/08 Mucosal Immunology of Helicobacter-Induced Gastritis(2nd Renewal) NIH/ NIDDK

R01- DK46461PI: S.J. Czinn (30%)$1,250,000

9/1/00-8/31/06 Program Project on “Pediatric IBD: Key to Early Pathogenic Events”NIH/NIDDKP01-DK57756Overall PI: S. J. Czinn as of January 2005

Project #3 “Bacterial Modulation of Gastrointestinal Inflammation”PI: S.J. Czinn (15%)$ 500,000

9/1/00-8/31/06 Program Project on “Pediatric IBD: Key to Early Pathogenic Events” NIH/NIDDKP01-DK57756Overall PI: Claudio Fiocchi

Core A “Clinical Patient Core”PI: S.J. Czinn (5%)$ 350,000

9/30/98-9/30/03 Program Project on “Mucosal Immunity and Infection”(Renewal) NIH/NIAID

P01-AI36359Overall PI: Michael Lamm

Project #2 “Vaccines for Helicobacter Disease”Co-PI: S.J. Czinn (10%) $551,000

9/1/97-8/31/02 “Risk Factors for Gastric Disease in Pediatric H. pylori”NIH/NIDDKR0l DK-53078PI: B. GoldCo-I: S.J.Czinn (10%)

12/1/97-11/30/02 “Mucosal Immunology of Helicobacter-Induced Gastritis” (1st Renewal) NIH/NIDDK

R01 DK46461


PI: S.J. Czinn (15%)$849,125

9/30/95-9/30/98 Program Project on “Mucosal Immunity and Infection”NIH/NIAIDP01 AI36359Overall PI: Michael Lamm

Project #2 “Oral Vaccines for Helicobacter Disease”PI: S.J. Czinn (25%)$231,000

12/1/94-11/30/97 “Mucosal Immunology of Helicobacter-Induced Gastritis” NIH/NIDDKR01 DK46461PI: S.J. Czinn (25%)$466,327

7/1/88-6/30/94 “Immunology of Campylobacter pylori in Gastric Disease” NIH/NIAIDR29 AI 25-818-01 Al PI: S.J. Czinn (35%)$349,994

Clinical Contracts/Industry Grants:4/1/98-3/31/99 “The Genetic Basis of H. pylori Gastroduodenal Disease”

Howard Hughes pilot studyPI: S.J. Czinn$40,000

7/1/98-12/31/98 “Pathogenesis of H. pylori”Millennium Pharmaceuticals, Inc.PI: S.J. Czinn$13,000

1/1/93-10/31/98 “H. pylori Vaccine” OraVax, Inc.PI: S.J. Czinn$500,000

9/92-7/93 “Characterization of Experimental Infection by Helicobacter mustelae in Ferrets”

The Procter & Gamble CompanyPI: S.J. Czinn$46,800


9/92-7/93 “Ability of Hyperimmune Bovine Colostrum to Eradicate Helicobacter mustelae Infection”

OraVax Inc.PI: S.J. Czinn$35,380

1/1/91-6/1/91 “Antimicrobial Therapy for H. Pylori”The UpJohn CorporationPI: S.J. Czinn$2,000

7/1/89-6/30/90 “Ferret Model of Helicobacter Gastritis”The Procter & Gamble CompanyPI: S.J. Czinn$22,200

7/1/89-6/30/90 “Treatment of Non-Ulcer Dyspepsia”Merck Sharp & DohmePI: S.J. Czinn$2,000

PATENTS:U.S. Patent # 5,538,729Steven J. Czinn and John G. Nedrud"Oral Treatment of Helicobacter Infection"Issued July 23, 1996

PUBLICATIONS:

Peer Reviewed Articles:

1. Anton AH, Czinn S, Jazwa J, Tam L, Amaranth L: Trimethaphan cansylate (arfonad) and human plasma cholinesterase. Research Communications in Chemical Pathology and Pharmacology 2:375-383, 1979.

2. Czinn SJ , Speck WT, Rosenkranz HS: Abnormalities in the development of the American sea urchin induced by nalidixic acid. Mutation Research 91:119-121, 1981.

3. Speck WT, Czinn SJ, Rosenkranz HS: Possible basis for the dichotomy in the action of DNA gyrase inhibitors on eurokaryotes. Mutation Research 105:223-227, 1982.

4. Czinn SJ , Lamm ME: Selective chemotaxis of subsets of B lymphocytes from gut-associated lymphoid tissue and its implications for the recruitment of mucosal plasma cells. Journal of Immunology 136:3607-3611, 1986.


5. Czinn SJ , Dahms BB, Jacobs CH, Kaplan B, Rothstein FC: Campylobacter-like organisms in association with symptomatic gastritis in children. Journal of Pediatrics 109:80-83, 1986.

6. Czinn SJ , Carr H, Aronoff S: Susceptibility of Campylobacter pyloridis to three macrolide antibiotics (Erythromycin, Roxithromycin (RU28965), and CP 62,993) and Rifampin. Antimicrobial Agents and Chemotherapy 30:328-329, 1986.

7. Czinn SJ , Carr H: Rapid diagnosis of Campylobacter Pyloridis-associated gastritis. Journal of Pediatrics 110:569-570, 1987.

8. Hupertz VF, Carr HS, Czinn SJ: Susceptibility of Campylobacter pylori to seven new quinolone antibiotics and nalidixic acid. Chemotherapy 34:341-344, 1988.

9. Hupertz V, Czinn S: Demonstration of a cytoxin from Campylobacter pylori. European Journal of Clinical Microbiology & Infectious Diseases 7:575-578, 1988.

10. Kilbridge PM, Dahms BB, Czinn SJ: Campylobacter pylori-associated gastritis and peptic ulcer disease in children. American Journal of Diseases of Children 142:1149-1152, 1988.

11. Czinn SJ , Carr H, Sheffler L, Aronoff S: Serum IgG antibody to the outer membrane proteins of Campylobacter pylori in children with gastroduodenal disease. Journal of Infectious Diseases 159:586-89, 1989.

12. Czinn SJ , Carr H, Hupertz V: Susceptibility of Campylobacter pylori to the newer cephalosporin antibiotics. Chemotherapy 35:164-167, 1989.

13. Czinn SJ , Speck WT: Campylobacter pylori: a new pathogen. Journal of Pediatrics 114(l):670-672, 1989.

14. Czinn SJ , Carr HS, Speck WT: Effects of topical anesthetic agents on Campylobacter pylori. Pediatric GI & Nutrition 9:46-48, 1989.

15. Morrison S, Hoffenberg E, Dahms BB, Czinn SJ: Hypertrophic gastric folds in association with Campylobacter pylori gastritis. Radiology 171:819-821, 1989.

16. Estrin HM, Hassan MO, Carr HS, Czinn SJ: Antral brushings and biopsies for gastric Campylobacter pylori: a comparative study of a rapid urease test, culture, and histology. Canadian J Gastroenterology 3(3):91-94, 1989.

17. Abramowsky C, Hupertz V, Kilbridge P, Czinn S: Intestinal lymphangiectasia in children: a study of upper gastrointestinal endoscopic biopsies. Pediatric Pathology 9:289-297, 1989.

18. Tosi MF, Czinn SJ: Opsonic activity of specific human IgG against Helicobacter pylori. J Infect Dis 162:156-162, 1990.


19. Czinn SJ , Carr HS, Speck WT: The diagnosis of gastritis caused by Helicobacter pylori in children by means of an ELISA. Reviews of Infectious Diseases 13(Suppl 8):S700-703, 1991.

20. Czinn SJ , Bertram TA, Murray PD, Yang P: Relationship between gastric inflammatory response and symptoms in patients infected with Helicobacter pylori. Scandinavian Journal of Gastroenterology 26:(Suppl 181):33-37, 1991.

21. Bertram TA, Murray PD, Jerdak G, Graham D, Yang P, Czinn S: Gastritis associated with infection by Helicobacter pylori in humans: geographical differences. Scandinavian Journal of Gastroenterology 26(Suppl 181):1-8, 1991.

22. Czinn SJ , Nedrud JG: Oral immunization against Helicobacter pylori. Infection and Immunity 59(7):2359-2363, 1991.

23. Westblom TU, Madan E, Gudipati S, Midkiff BR, Czinn SJ: Diagnosis of Helicobacter pylori infection in adult and pediatric patients using Pyloriset, a rapid latex agglutination test. J Clin Microbiol 30:96-98, 1992.

24. Tosi MF, Sorensen RU, Czinn SJ: Cell-mediated immune responsiveness to Helicobacter pylori in healthy seropositive and seronegative adults. Immunol Infect Dis 2:133-136, 1992.

25. Czinn SJ , Cai A, Nedrud JG: Protection of germ-free mice from infection by Helicobacter felis after active oral or passive immunization. Vaccine 11(6):637-642, 1993.

26. Westblom TU, Phadnis S, Yang P, Czinn SJ: Diagnosis of Helicobacter pylori in gastric juice aspirates using polymerase chain reaction (PCR). Clin Infect Dis 16:367-71, 1993.

27. Westblom TU, Lagging LM, Midkiff BR, Czinn SJ: Evaluation of QuickVue, a rapid enzyme immunoassay test for the detection of serum antibodies to Helicobacter pylori. Diagn Microbiol Infect Dis 16:317-320, 1993.

28. Westblom TU, Midkiff BR, Czinn SJ: In vitro susceptibility of Helicobacter pylori against trospectomycin, pirlimycin (U-57930E), mirincamycin (U-24729A), and N-demethyl clindamycin (U-26767A). Eur J Clin Microbiol Infect Dis 12(7):560-562, 1993.

29. Czinn SJ : Dyspepsia in Children. J Pediatr Gastroenterol Nutr 17:237-238, 1993.

30. Czinn SJ , Lee A, Nedrud JG: The role of vaccination in preventing infection with Helicobacter pylori. Mucosal Immunology Update 2(4):6-8, 1994.

31. Blanchard TG, Czinn SJ, Nedrud JG, Redline RW: Helicobacter-associated gastritis in SCID mice. Infect Immun 63(3):1113-1115, 1995.


32. Blanchard TG, Czinn SJ, Maurer R, Thomas WD, Soman G, Nedrud JG: Urease-specific monoclonal antibodies prevent Helicobacter felis infection in mice. Infect Immun 63(4):1394-1399. 1995.

33. Czinn SJ , Cai A, Sellman SPB, Nedrud JG. Oral Immunization Induces Humoral and Cell-Mediated Immunity and Protects Germ-Free Mice Against Infection From Helicobacter Felis. Adv Exp Med Biol 371:1645-1648, 1995.

34. Gold BD, Dytoc M, Huesca M, Philpott D, Kuksis A, Czinn S, Lingwood CA, Sherman PM: Comparison of Helicobacter mustelae and Helicobacter pylori adhesion to eukaryotic cells in vitro. Gastroenterology 109:692-700, 1995.

35. Czinn SJ : Helicobacter pylori gastroduodenal disease in infants and children. Japanese Journal of Pediatric Gastroenterology and Nutrition 9:1-7, 1995.

36. Sellman S, Blanchard TG, Nedrud JG, Czinn SJ: Vaccine strategies for prevention of Helicobacter pylori infection. Eur J Gastroenterol Hepatol 7:S1-S6, 1995.

37. Blanchard TG, Nedrud JG, Czinn SJ: The possible role of vaccines in H. pylori infection. Argomenti di Gastroenterologia Clinica 8:263-272, 1995.

38. Mohammadi M, Redline R, Nedrud J, Czinn S: Role of the host in pathogenesis of Helicobacter-associated gastritis: H. felis infection of inbred mouse strains. Infect & Immun 64:238-245, 1996.

39. Czinn S , Bierman JC, Diters RW, Leunk RD: Characterization and therapy of experimental infection by Helicobacter mustelae in ferrets. Helicobacter 1:43-51, 1996.

40. Mohammadi M, Czinn S, Redline R, Nedrud J: Characterization of the cell-mediated immune response following Helicobacter immunization and/or infection in mice. J of Immunol 156:4729-4738, 1996.

41. Cuenca R, Blanchard TG, Czinn SJ, Nedrud JG, Monath TP, Lee CK, Redline RW: Therapeutic immunization against Helicobacter mustelae in naturally infected ferrets. Gastroenterology 110:1770-1775, 1996.

42. Gold BD, Islur P, Neumann AW, Policova Z, Czinn S, Sherman PM: Surface Hydrophobicity properties of Helicobacter mustelae and ferret gastrointestinal mucosa. Clin Invest Med 19: 92-100, 1996.

43. Kugathasan S, Czinn SJ: Is repeated exposure to H. pylori necessary for chronic H. pylori infection? (editorial). Helicobacter 2: 155-156, 1997.

44. Mohammadi M, Nedrud J, Redline R, Lycke N, Czinn S. Murine CD4 T-cell response to Helicobacter infection: TH1 cells enhance gastritis and TH2 cells reduce bacterial load. Gastroenterology 113: 1848-1857, 1997.


45. Freston JW, Ahnen DJ, Czinn SJ, Earnest DL, Farthing MJ, Gorbach SL, Hunt RH, Sandler RS, Schuster MM: Review and analysis of the effects of olestra, a dietary fat substitute, on gastrointestinal function and symptoms. Regul Toxicol Pharmacol Oct: 26 (2): 210-218, 1997.

46. Nedrud JG, Czinn SJ, Lee A: Role of the host in Helicobacter Disease. Gastroenterology 112(2):670, 1997.

47. Blanchard TG, Czinn SJ: Immunological determinants that may affect the Helicobacter pylori cancer risk. Aliment Pharmacol Ther 12:83-90, 1998.

48. Blanchard TG, Lycke N, Czinn SJ, Nedrud JG: Recombinant Cholera toxin B subunit is not an effective mucosal adjuvant for oral immunization of mice against H. felis. Immunology 93:22-27, 1998.

49. Kugathasan S, Czinn SJ: Endoscopy personnel and the transmission of Helicobacter pylori infection (Editorial). Gastrointestinal Endoscopy 48:317-318, 1998.

50. Klein PD, Malaty HM, Czinn SJ, Emmons SC, Martin RF, Graham DY. Normalizing results of 13C-urea breath testing for CO2 production rates in children. J Pediatr Gastroenterol Nutr 29(3):297-301, 1999.

51. Nedrud JG, Czinn, SJ. Host, heredity and helicobacter. Gut 45(3):323-4, 1999.

52. Czinn SJ , Nedrud JG, Working towards a Helicobacter pylori vaccine. Gastroenterology 116(4): 990-3, 1999.

53. Blanchard TG, Czinn SJ, Nedrud JG. Host response and vaccine development to Helicobacter pylori infection. Curr Top Microbiol Immunol 241:181-213, 1999.

54. Blanchard TG, Nedrud JG, Reardon ES., Czinn SJ. Qualitative and quantitative analysis of the local and systemic antibody response in mice and humans with Helicobacter immunity infection. J Infect Dis 179(3):725-8, 1999.

55. Czinn SJ . Serodiagnosis of Helicobacter pylori in pediatric patients. J Pediatr Gastroenterol Nutr 28(2):132-4, 1999.

56. Blanchard TC, Czinn SJ, Redline RW, Sigmund N, Harriman G, Nedrud JG. Antibody-independent protective mucosal immunity to gastric Helicobacter infection in mice. Cell Immunol 191(1):74-80, 1999.

57. Blanchard, T, Nedrud, J, Czinn, S. Local and systemic antibody responses in humans with Helicobacter pylori infection. Can J of Gastroenterol 13 (7):591-594, 1999.


58. Gold BD, Colletti RB, Abbott M, Czinn SJ, Elitsur Y, Hassall E, Maccarthur C, Snyder J, Sherman PM, Helicobacter pylori infection in children: recommendations for diagnosis and treatment. J Pediatr Gastroenterol Nutri 31(5):490-7, 2000.

59. Blanchard TG, Czinn SJ. Immunology of Helicobacter pylori and prospects for vaccine. Gastroenterol Clin North Am 29(3):671-85, 2000.

60. Chelimsky G, Czinn SJ. Helicobacter pylori infection in children: Update. Curr Opinion Pediatri 12(5):460-2, 2000.

61. Kersulyte D, Mukhopadhyay AK, Velapatino B, Su WW, Pan ZJ, Garcia C, Hernandez V, Valdez Y, Mistry RS, Gilman RH, Yuan Y, Gao H, Alarcon T, Lopez-Brea M, Nair GB, Chowdhury A, Datta S, Shirai M, Nakazawa T, Ally R, Segal I, Wong BCY, Lam SK, Olfat FO, Boren T, Engstrand L, Torres O, Schneider R, Thomas JE, Czinn S, Berg DE: Differences in genotypes of Helicobacter pylori from different human populations. Journal of Bacteriology 182 (11): 3210-3218, 2000.

62. Gold BD, Van Doorn LJ, Guarner J, Owens M, Pierce-Smith D, Song Q, Hutwagner L, Sherman PM, De Mola, OL, Czinn SJ. Genotypic, Clinical and demographic characteristics of children infected with Helicobacter pylor. J. Clin Microbiol 39(4):1348-52, 2001.

63. Gottwein J, Blanchard TG, Targoni OA, Eisenberg JGC, Trezza R, Redline RV, Nedrud JG, Lehmann PV, Czinn SJ: Type 2 Protective Anti-Helicobacter Immunity is Induced with Aluminum Hydroxide or Complete Freund’s Adjuvant by Systemic Immunization. J. Infect Dis 184:308-14, 2001.

64. McGovern KJ, Blanchard TG, Gutierrez JA, Czinn SJ, Krakowka S, Youngman P. Gamma Glutamytransferase is a Helicobacter pylori virulence factor but is not essential for colonization. Infect Immun 69:4168-73, 2001.

65. Blanchard TG, Czinn SJ. Helicobacter pylori acquisition and transmission: Where does it all begin? Gastroenterology 121:483-5, 2001.

66. Chelimsky G, Czinn SJ. Peptic Ulcer Disease in Children. Pediatr Rev 22:349-55, 2001.

67. Chelimsky G, Czinn SJ. Techniques for the Evaluation of Dyspepsia in Children. J Clin Gastroenterol 33:11-3, 2001.

68. Garhart, A., Redline, R., Nedrud, J., Czinn, S. Clearance of Helicobacter pylori Infection and Resolution of Postimmunization Gastritis in a Kinetic Study of Prophylactically Immunized Mice. Infect. & Immunity 70:3529-3538, 2002.

69. Nedrud, J., Blanchard S., Czinn, S., Helicobacter pylori inflammation and immunity. Helicobacter 7:24-29, 2002.


70. Czinn S , Gold B, Dickinson C, Ramakrishna J, Orenstein S. Research agenda for pediatric gastroenterology, hepatology and nutrition: acid-peptic diseases. Report of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition for the Children’s Digestive Health and Nutrition Foundation. J. Pediatr Gastroenterol Nutri 35 Suppl 3:S250-3, 2002.

71. Sherman P, Czinn S, Drumm B, Gottrand F, Kawakami E, Madrazo A, Oderda G, Seo J, Sullivan P, Toyoda S, Weaver L, WU T, Helicobacter pylori infection in children and adolescents: working group report of the first world congress of pediatric gastroenterology, hepatology, and nutrition. J. Pediatr Gastroenterol Nutr 35 Suppl 2:S128-133, 2002.

72. Chelimsky G, Blanchard, S, Sivit C, Davis I, Czinn S. Pneumatosis Intestinalis and Diarrhea in a child following renal transplantation. Pediatr Transplant 7(3):236-9, 2003.

73. Guarner J, Bartlett J, Whistler T, Pierce-Smith D, Owens M, Kreh R, Czinn S, Gold B. Can pre-neoplastic lesions be detected in gastric biopsies of children with Helicobacter pylori Infection? J Pediatr Gastroenterol Nutr 37(3):309-14, 2003.

74. Orenstein S, Shalaby T, Devandry S, Liacouras C, Czinn S, Dice J, Simon T, Ahrens S, Stauffer L. Famotidine for infant gastro-esophageal reflux: a mutli-centre, randomized, placebo-controlled, withdrawal trail. Aliment Pharmacol Ther 17(9):1097-107, 2003.

75. Aronow S, Aronow H, Blanchard T, Czinn S.J., Chelimsky G, Hair relaxers a benign caustic ingestion? J Pediatr Gastroenterol Nutri 36(1):120-5, 2003.

76. Garhart C.A,. Heinzel F.P., Czinn S.J., Nedrud J.G.. Vaccine-induced reduction of Helicobacter pylori colonization in mice is interleukin-12 dependent but gamma interferon and inducible nitric oxide synthase independent. Infect Immun. 71:910-21, 2003.

77. Garhart C.A., Nedrud J.G., Heinzel F.P., Sigmund N.E., Czinn S.J.. Vaccine-induced protection against Helicobacter pylori in mice lacking both antibodies and interleukin-4. Infect Immun. 71:3628-33, 2003.

78. Eisenberg J.C., Czinn S.J., Garhart C.A., Redline R.W., Bartholomae W.C., Gottwein J.M., Nedrud J.G., Emancipator S.E., Boehm B.B., Lehmann P.V., Blanchard T.G. Protective efficacy of anti-Helicobacter pylori immunity following systemic immunization of neonatal mice. Infect Immun. 71:1820-7, 2003.

79. Duck WM, Sobel J, Pruckler JM, Song OS, Swerdlow D, Friedman C, Sulka A, Swaminathan B, Taylor T, Hoekstra M, Griffin P, Smoot D, Peek R, Metz DC, Bloom PB, Goldschmid S, Parsonnet J, Triadafilopoulos G, Perez-Perez GI, Vakil N, Ernst P, Czinn S, Dunne D, Gold BD: Antimicrobial resistance incidence and risk factors among Helicobacter pylori-infected persons. Emerging Infectious Diseases 10 (6): 1088-1094, 2004.


80. Basu M, Czinn SJ, Blanchard TG: Absence of catalase reduces long-term survival of Helicobacter pylori in macrophage phagosomes. Helicobacter 9 (3): 211-216, 2004.

81. Drakes M, Blanchard T, Czinn S: Bacterial probiotic modulation of dendritic cells. Infection and Immunity 72 (6): 3299-3309, 2004.

82. Czinn SJ : Helicobacter pylori infection: Detection, investigation, and management. Journal of Pediatrics 146 (3): S21-S26 Suppl., 2005.

83. Fiocchi C, Cucchiara T, Czinn SJ, Grand RJ, Levine AD, Seidman JG.: First International Symposium on: Pediatric inflammatory bowel disease: September 16-18, 2003; Irvington, Virginia, USA. Journal of Pediatric Gastroenterology And Nutrition 40: S1-S52 Suppl. 1 2005.

84. Arora S, Czinn SJ: Vaccination as a method of preventing Helicobacter pylori-associated gastric cancer. Cancer Epidemiology Biomarkers & Prevention 14 (8):1890-1891, 2005.

85. Matsumoto Y, Blanchard TG, Drakes ML, Basu M, Redline RW, Levine AD, Czinn SJ: Eradication of Helicobacter pylori and resolution of gastritis in the gastric mucosa of IL-10-deficient mice. Helicobacter 10 (5):407-415, 2005.

86. Drakes ML, Blanchard TG, Czinn SJ: Colon lamina propria dendritic cells induce a proinflammatory cytokine response in lamina propria T cells in the SCID mouse model of colitis. J Leukoc Biol 78:1291-1300, 2005

Invited Reviews/Chapters/Proceedings

1. Czinn SJ , Robinson J, Lamm ME: Chemotaxis as a mechanism for recruitment of mucosal plasma cell precursors. In: Mestecky J, McGhee JR, Bienenstock J, Ogra PL, eds., Recent Advances in Mucosal Immunology 216A:305-311, 1987.


2. Czinn SJ , Lamm ME: Speculations on the homing mechanism of precursors of mucosal plasma cells. In: Mucosal Immunity and Infections at Mucosal Surfaces. Ed., W. Strober, M.E. Lamm, J.R. McGhee, and S.P. James, pp. 195-202. New York, Oxford University Press, 1988.

3. Vanderhoof JA, Drumm B, Czinn SJ: Peptic ulcer, gastritis and Campylobacter pylori. AAP Pediatric Update 10:5, 1989.

4. Czinn SJ , Speck WT: Campylobacter pylori: a new pathogen. Adv Pediatr Infect Dis 5:221-237, 1990.

5. Czinn SJ : Pediatric Gastroenterology. Nelson Textbook of Pediatrics Update 7. Ed., R. Behrman, V. Vaughan, pp. 85-94, 1990.

6. Czinn SJ : Helicobacter pylori-induced gastritis in childhood. In: Malfertheiner, P. Proceedings of the Workshop on Gastroduodenal Pathology and Campylobacter pylori. Springer-Verlag, Berlin (181-187), Ulm, 1990.

7. Czinn SJ , Halpin T: Acute Hepatic Failure. In: Practical Guide to Pediatric Intensive Care, Editor, Jeffrey Blumer, Mosby, 1991.

8. Czinn SJ : Helicobacter pylori. In: Rudolph's Pediatrics 19th Edition, Editor, Abraham M. Rudolph, M.D., Appleton & Lange, 1991.

9. Czinn SJ : Pancreatitis. In: Manual of Emergency Pediatrics, Editor, Robert Reece, W.B. Saunders, 1992.

10. Czinn SJ : Helicobacter pylori Gastroduodenal disease in children. In: Pediatric Gastrointestinal Disease Pathophysiology, Diagnosis and Management, Eds., Robert Wyllie, M.D., Jeffrey S. Hyams, M.D., W.B. Saunders Company, 1992.

11. Westblom TU, Phadnis S, Normark S, Czinn SJ: Diagnosis of Helicobacter pylori in gastric juice aspirates using polymerase chain reaction (PCR). Proceedings of the Workshop on Helicobacter pylori, Bologna, Italy 1993.

12. Sellman S, Blanchard TG, Nedrud JG, Czinn SJ. Vaccine Strategies for prevention of Helicobacter pylori infections. Eur J Gastroenterol Hepatol 7 (suppl 1):S1-S6, 1995.

13. Kugathasan S, Czinn SJ. Management of gastrointestinal disorders in children. Curr Opin Gastroenterol 11;504-507, 1995.

14. Czinn S : Toward a vaccine. Proceedings of “Helicobacter pylori-Progress and prospects". Los Angeles, CA, Page 37-42, 1995.

15. Czinn SJ , Glassman MS. "Helicobacter pylori in infants and children". Adv Ped Infec Dis 11:389-401, 1996.


16. Czinn SJ , Lee A, Nedrud JG. The role of vaccination in preventing infection with Helicobacter pylori. Mucosal Immunology Update 2:6-8, 1996.

17. Nedrud JG, Czinn SJ: Helicobacter pylori: An update. Current Opin in Gastro 12:62-67, 1996.

18. Kugathasan S, Czinn SJ. Gastroduodenal inflammation and related disorders in children. Curr Opin Gastroenterol 12:537-543, 1996.

19. Czinn SJ , Nedrud JG. Helicobacter pylori: Infection, inflammation and the host immune response. In: Kagnoff M, Kiyono H, eds. Essentials of Mucosal Immunology San Diego: Academic Press, pp. 391-403, 1996.

20. Ernst PB, Reyes VE, Nedrud JG, Czinn SJ. In: Mucosal immunity to H. pylori: Implications for vaccine development. Kiyono H, Ogra PL, McGhee JR, eds. Mucosal Vaccines San Diego: Academic Press, pp. 255-267, 1996.

21. Nedrud JG, Czinn SJ. Helicobacter pylori. Curr Opin Gastroenterol 13:71-78, 1997.

22. Kugathasan S, Czinn SJ. Upper gastrointestinal motility disorders in children. Curr Opin Gastroenterol 13:486-489, 1997.

23. Nedrud JG, Czinn SJ. Oral immunization for the prevention and treatment of infection with Helicobacter. In: The Immunobiology of H. pylori: from Pathogenesis to Prevention. Ernst PB, Michetti P, Smith P, eds. New York: Lippincott-Raven, pp. 273-286, 1997.

24. Czinn SJ , Nedrud JG. In: Immunopathology of Helicobacter pylori infection and disease. Strober W, Kelsall B, eds. Springer Seminars in Immunopathology Berlin: Springer, 18:495-513, 1997.

25. Kugathasan S, Czinn SJ. Helicobacter pylori and gastrointestinal disorders in children. In: Recent advances in pediatrics. David TJ ed. Edinburgh; Churchill Livinstone, 16; 91-104, 1997.

26. Czinn SJ . What is the role for vaccination in Helicobacter pylori? Gastroenterology 113:s149-s153, 1997.

27. Nudrud JG, Czinn SJ, Blanchard TG. H. pylori vaccines. In: Lee A, Kolesnikow T, Eds. Helicobacter pylori-A global pathogen: Bailliere, 1998

28. Czinn SJ , Lamm, ME: New insights in the role of IgA in gut protection. Cur Opin Gastroenterol 14:488-491, 1998.

29. Guimber D, Chelimsky G, Gottrand F, Czinn SJ: Paediatrics. Current Opinion in Gastroenterology 15: S49-S52 Suppl. 1, 1999.


30. Chelimsky G, Czinn SJ. Methodologic Considerations in the Management of Pediatric Recurrent Abdominal Pain. Evidence Based Gastroenterology: A Framework for Clinical practice. Ervine, EJ and Hunt, Eds., BC Decker, Inc., 19-27; 2001.

31. Chelimksy G, Dahms B, Czinn SJ. Peptic Ulcer Disease and Gastritis. Pediatric Gastroenterology and Nutr in Clinical Practice. Lifschitz C, Ed., 2001.

32. Blanchard TG, Drakes ML, Czinn SJ: Helicobacter infection: pathogenesis. Current Opinion in Gastroenterology 20 (1): 10-15, 2004.

Letters to the Editor:

1. Westblom TU, Czinn SJ; Helicobacter-Pylori Serology – Reply. Journal of Clinical Microbiology, 31 (1): 173-173, 1993.

2. Dahms BB, Czinn SJ, Kilbridge P: Campylobacter-Pylori Gastritis And Peptic-Ulcer In Children – Reply. American Journal of Diseases of Children, 143 (8): 878-878, 1989.

Selected Abstracts (Presented):

1. Czinn S , Carr H, Speck WT: Effect of nalidixic acid, novobiocin and oxylinic acid on embryonic development and macromolecular biosynthesis. Pediatric Research 15:642, 1981.

2. Czinn S , Kahn T, Frank D, Speck WT, Blumer J: Teratogenic effects of phenytoin, valproic acid, carbamazapine and phenobarbital in the developing American sea urchin. Pediatric Research 17:147A, 1983. Platform Presentation.

3. Czinn S , Lamm M: Chemotaxis of IgA lymphocytes. Poster Presentation at workshop on intestinal immunity and inflammation, 1984.

4. Czinn SJ , Lamm ME: Chemotaxis and the mucosal immune system. Presented at Science Day, Rainbow Babies and Children’s Hospital, 1985.

5. Czinn SJ , Lamm ME: Selective chemotaxis of mucosal IGA lymphocytes. Submitted to North American Society for Pediatric Gastroenterology and Nutrition, 1985.

6. Czinn SJ , Dahms B, Jacobs G, Kaplan B, Rothstein FC: Campylobacter-like organisms (CLO) in association with symptomatic gastritis in children. Poster Presentation, Society for Pediatric Research, Washington, D.C., 1986.

7. Czinn SJ , Lamm ME: Speculations on the homing mechanism of the precursors of mucosal plasma cells. Poster Presentation at Conference on mucosal immunity and infection at mucosal surfaces program, 1985.


8. Czinn SJ , Robinson J, Lamm ME: Chemotaxis as a mechanism for recruitment of mucosal plasma cell precursors. Poster Presentation at International Congress of Mucosal Immunology, Niagara Falls, New York, 1986.

9. Lamm ME, Czinn SJ, Rao CK, Kaetzel CS: Origins of secretory IgA. International Symposium on the Immunology of the Gastro-intestinal Tract and Liver. Jerusalem, Israel, 1987.

10. Hupertz VF, Czinn SJ: Demonstration in an animal model of a heat labile toxin produced by Campylobacter pyloridis. Society for Pediatric Research, 1987.

11. Czinn SJ , Hupertz VF, Carr H, Labrozzi P, Aronoff SC: Immunogenicity of Campylobacter pyloridis (CP) outer membrane proteins. Society for Pediatric Research, 1987.

12. Hupertz VF, Czinn SJ, Gregory D, Kliegman RM: Clinically significant esophagitis in tube fed high-risk neonates: A previously unrecognized problem. Society for Pediatric Research, 1987.

13. Carr H, Estrin H, Hupertz VF, Czinn SJ: Inhibitory effects of topical anesthetic agents on Campylobacter pyloridis culture results. American Gastroenterological Association, 1987.

14. Estrin H, Hassan M, Czinn SJ: Antral brushings and biopsies for gastric Campylobacter pyloridis: a comparative study of a rapid urease test, culture, and histology. American Society for Gastrointestinal Endoscopy, 1987.

15. Elmets CA, Lederman MM, Czinn S: In vivo production of a T-lymphocyte cytokine in the skin at sites of contact dermatitis. The Society for Investigative Dermatology, 1987.

16. Abramowsky C, Hupertz V, Czinn S, Kilbridge P: Intestinal lymphangiectasia (IL). Society for Pediatric Pathology, 1987.

17. Kilbridge P, Dahms B, Czinn S: Campylobacter pylori in children with nonspecific gastritis. International Academy of Pathology, 1988.

18. Czinn SJ , Kilbridge P, Dahms B: The natural history of Campylobacter pylori (CP) in children. The American Pediatric Society, The Society for Pediatric Research, 1988.

19. Czinn SJ , Carr HS: The diagnosis of Campylobacter pylori (CP) gastritis using an enzyme linked immunoassay (ELISA). The American Pediatric Society, The Society for Pediatric Research, 1988.

20. Czinn S , Carr H, Aronoff S: Immunogenicity of Campylobacter pylori (CP) outer membrane proteins. American Gastroenterological Association, 1987.


21. Tosi M, Czinn SJ: Role of specific antibody and complement in promoting phagocytosis of Campylobacter pylori. Poster Presentation, The Inter-science Conference on Antimicrobial Agents and Chemotherapy, 1988.

22. Czinn SJ , Carr H, Yang P: Antibody response to Campylobacter pylori (C. pylori) - a comparison of the systemic and mucosal immune system. The American Gastroenterological Association, 1989.

23. Yang P, Dahms B, Carr H, Czinn S: Naturally occurring ferret Campylobacter (CLO)-associated gastric disease: Characterization and response to non-steroidal anti-inflammatory agents. The American Gastroenterological Association, 1989.

24. Czinn SJ , Tidwell JE: Outer membrane protein characterization of Campylobacter pylori (CP) strains causing peptic ulcers. The American Pediatric Society, The Society for Pediatric Research, 1989.

25. Czinn SJ , Carr HS: Gastrointestinal immune response following oral immunization with Campylobacter pylori (CP). The American Pediatric Society, The Society for Pediatric Research, 1989.

26. Halpin TC, Emancipator SN, Czinn SJ: Chronic enteropathy with prolonged gluten feeding in a mouse model. North American Society for Pediatric Gastroenterology and Nutrition, 1989.

27. Czinn SJ , Dahms B, Speck WT: The natural history of Campylobacter pylori gastritis and peptic ulcer disease in children. Workshop Gastroduodenal Pathology and Campylobacter pylori -2nd Meeting of the European Campylobacter pylori Study Group, 1989.

28. Garde KA, Carr HS, Czinn SJ: Helicobacter pylori (H. pylori) and ABO blood group antigens. The American Pediatric Society, The Society for Pediatric Research, 1990.

29. Yang P, Carr H, Carey J, Czinn S: The systemic and mucosal immune response to Helicobacter pylori in AIDS patients - a paradox. The American Gastroenterological Association, San Antonio, Texas, 1990.

30. Czinn S , Carr H, Yang P: Demonstration of a soluble phosphodiesterase, phospholipase C, (PLC) produced by Helicobacter pylori: a potential virulence factor. The American Gastroenterological Association, San Antonio, Texas, 1990.

31. Westblom TU, Madan E, Czinn S, Gudipati S, Midkiff BR: Evaluation of Pyloriset, a latex agglutination test for detection of Helicobacter pylori infection. Third Workshop on Gastroduodenal Pathology and Campylobacter (Helicobacter) pylori, Toledo, Spain, Nov 8-10, 1990.

32. Bertram TA, Murray PD, Jerdack G, Yang P, Czinn S: Relationships between gastric inflammatory reaction, immune response and symptoms in patients infected with


Helicobacter pylori. Third Workshop Gastroduodenal Pathology and Campylobacter (Helicobacter) pylori, Toledo, Spain, Nov 8-10, 1990.

33. Repucci AH, Czinn SJ: Helicobacter pylori: Long-term follow-up of childhood infection. North American Society for Pediatric Gastroenterology and Nutrition, Chicago, Illinois, 1990.

34. Westblom TU, Madan E, Czinn S, Gudipati S, Midkiff BR: Sensitivity and specificity of pyloriset, a latex agglutination test for detection of Helicobacter pylori infection. American Gastroenterological Association, New Orleans, Louisiana, 1991.

35. Czinn SJ , Nedrud JG: Serum and mucosal immune response following oral immunization with Helicobacter pylori (H. pylori). American Gastroenterological Association, New Orleans, Louisiana, 1991.

36. Czinn SJ , Cai A, Nedrud J: Oral immunization protects germ-free mice against infection from Helicobacter felis. American Gastroenterological Association, San Francisco, California, 1992.

37. Czinn SJ , Cai A, Sellman S, Nedrud J: Oral immunization induces humoral and cell-mediated immunity and protects germ-free mice against infection from H. felis. 7th International Congress of Mucosal Immunology, Prague Czechoslovakia, 1992.

38. Sellman SPB, Cai A, Nedrud J, Czinn SJ: Oral immunization against Helicobacter felis induces cell-mediated and humoral immunity in germ-free mice. American Gastroenterological Association, Boston, Massachusetts, 1993.

39. Shaffer SE, Czinn SJ, Boyle JT: Is motility altered in chronic antral gastritis?: effects of Helicobacter mustelae infection on antral smooth muscle contractility in vitro. American Gastroenterological Association, Boston. Massachusetts, 1993.

40. Westblom TU, Lagging M, Madan E, Midkiff BR, Czinn S: Sensitivity and specificity of Quick-Que, an enzyme immunoassay test for the qualitative detection of IgG antibodies to Helicobacter pylori in human serum. ICAC, 1993.

41. Leunk RD, Czinn SJ, Bierman JC. An in vivo model to evaluate therapies for gastric infection in humans. Gastroenterology;106:A124, 1994.

42. Mohammadi M, Czinn S, Nedrud J. Oral immunization prevents Helicobacter felis colonization of conventional mice but does not prevent inflammation. Am J Gastroenterol; 89:1343, 1994.

43. Thomas WDJ, Blanchard TG, Lofsky A, Nedrud JG, Czinn SJ, Monath TP. Biochemical and immunologic comparison of recombinant H. felis and H. pylori ureases. Am J Gastroenterol; 89:1299, 1994.


44. Mohammadi M, Nedrud J, Czinn S. Spleen cell proliferation after infection or immunization of conventional mice with Helicobacter felis. Am J Gastroenterol; 89:1343, 1994.

45. Mohammadi M, Nedrud J, Redline R, Czinn S. Adoptive transfer of Helicobacter-specific lymphocytes enhances inflammation in mice. Clin Immuno Immunopathol; 76:S8, 1995.

46. Nedrud J, Blanchard T, Czinn S, Lycke N. Recombinant cholera toxin B subunit is not an adjuvant for oral immunization against Helicobacter felis in mice. J Cell Biochem; suppl 19A:261, 1995.

47. Blanchard TG, Czinn SJ, Nedrud JG. Identification of a novel protective antigen in H. felis. Clin Immuno Immunopathol; 76:S19, 1995.

48. Blanchard TG, Nedrud JG, Czinn SJ. IgA levels in the saliva and gastric mucus of H. felis infected and immunized mice. Clin Immuno Immunopathol; 76:S19, 1995.

49. Mohammadi M, Czinn S, Redline R, Nedrud J. Helicobacter induced inflammation varies in different strains of mice. Clin Immuno Immunopathol; 76:S20, 1995.

50. Blanchard TG, Nedrud JG, Czinn SJ. Qualitative and quantitative differences in the local immune response to Helicobacter in mice and humans following immunization or infection. Gastroenterology; 110:A867, 1996.

51. Mohammadi M, Nedrud J, Czinn S. IL-12 treatment induces susceptibility to Helicobacter-associated gastritis in the resistant BALB/c mouse strain (abstract). Gut; 39 suppl 2: A59, 1996.

52. Nedrud J, Blanchard T, Czinn S, Harriman G. Orally-immunized IgA deficient mice are protected against H. felis infection (Abstract). Gut: 39 suppl 2: A45, 1996.

53. Blanchard TG, Nedrud JG, Czinn SJ. Development of a rat model of H. pylori infection and disease to study the role of H. pylori in gastric cancer incidence. Gut; 39 suppl 2:A76, 1996.

54. Blanchard TG, Czinn SJ, Redline R, Sigmund N, Nedrud JG. Post-Immunization Gastritis Helicobacter Immunized/Challenged Mice. Gastroenterology; Vol.114 :G3830, 1998.

55. Jump R, Blanchard TG, Redline R, Nedrud JG, Zagorski BM, Czinn SJ. Role of the Host in Helicobacter-Associated Gastritis. Gastroenterology; Vol. 114: G4119, 1998.

56. Nedrud JG, Blanchard TG, Redline R, Sigmund N, Czinn SJ. Orally Immunized uMT Antibody Deficient Mice are Protected Against H. Felis Infection. Gastroenterology; Vol. 114: G4293, 1998.


57. Czinn SJ , Zogorski BM, Spencer M, Garhart C, Levine AD. Superinfection with Helicobacter Hepaticus Does Not Alter the Natural Course of Colitis in IL-10 Deficient Mice. Gastroenterology; Vol. 114: G3927, 1998.

58. Klein PD, Malaty HM, Graham DY, Czinn SJ, Emmons S, Martin R.: Urea hydrolysis rate (UHR) calculation normalizes the 13C-urea breath test for age, sex, height, and weight. Gastroenterology 114 (4): G0731 Part 2 Suppl. S APR 15 1998.

59. Zagorski BM, Carr H, Czinn SJ, et al.: Characterization of an intestinal Helicobacter isolated from feces, cecum and ileum of IL-10 deficient mice. Gastroenterology 116 (4): G3696 Part 2 APR 1999.

60. Levine AD, Zagorski BM, Carr H, Czinn SJ.: Characterization of an intestinal Helicobacter isolated from feces, cecum and ileum of IL-10 deficient mice. Gastroenterology 116 (4): G3299 Part 2 APR 1999.

61. Czinn SJ , Zagorski BM, Spencer DM, et al.: Eradication of a natural intestinal Helicobacter infection reduces the development of colitis in IL-10 deficient mice. Gastroenterology 116 (4): G3023 Part 2 APR 1999.

62. Orenstein SR, Blumer JL, Li BUK, Lavine JE, Grunow JE, Treem WE, Czinn SJ, et al.: Pediatric gastric pH data following ranitidine 75mg. Gastroenterology 116 (4): G1195 Part 2 APR 1999.

63. Gold BD, Owens ML, van Doorn LJ, Pierce-Smith DL, Grecmer J, Friedman CR, Sherman PM, deMola, DL, Muinos W, Czinn SJ.: Correlation of Helicobacter pylori genotype with clinical and demographic characteristics of infected children. Gastroenterology 116 (4): G0756 Part 2 APR 1999.

64. Blanchard TG, McGovern KJ, Youngman P, Guiterrez J, Czinn SJ.: Gamma-glutamyl transpeptidase is not essential for infection of the gastric mucosa by H-pylori. Gastroenterology 116 (4): G0619 Part 2 APR 1999.

65. Nedrud JG, Blanchard TG, Gottwein JM, Targoni OS, Eisenberg JC, Zagorski BM, Trezza RP, Redline RV, Tary-Lehmann, M, Lehman PV, Czinn SJ.: Systemic vaccination with aluminum hydroxide induces protective immunity against Helicobacter pylori infection in mice. Gut 45: A57-A57 Suppl. 3 SEP 1999.

66. Blanchard TG, McGovern KJ, Youngman P, Guiterrez J, Czinn SJ: Is gamma-glutamyl transpeptidase essential for infection of the gastric mucosa by H-pylori? Gut 45: A26-A26 Suppl. 3 SEP 1999.

67. Friedman CR, Gold BD, Zirnstein G, Smoot Dt, Cutler A, Perez-Perez GI, Goldschmid S, Metz DC, Parsonnet J, Czinn SJ, Dunne D, Ernst P: H-pylori antimicrobial resistance in the United States: Preliminary results of a 9-center study. Gastroenterology 118 (4): 3829 Part 1 Suppl. 2 APR 2000.


68. Eisenberg JC, Czinn SJ, Garhart C, et al.: Immunization of neonatal mice induces protective immunity against Helicobacter pylori. Gastroenterology 118 (4): 2653 Part 1 Suppl. 2 APR 2000.

69. Gold BD, Bulens S, Guarner J, Van Doorn LJ, Dahms B, Owens ML, Pierce-Smith DL, Czinn SJ.: Helicobacter pylori and gastroesophageal reflux disease (GERD): There is a relationship - The pediatric perspective. Gastroenterology 118 (4): 2610 Part 1 Suppl. 2 APR 2000.

70. Gunasekaran T, Pan WJ, Torres-Pinedo R, Book L, Gremse D, Steffen R, Czinn S, Chin YL, Pilmer BL, Fitzgerald J: Pharmacokinetics of lansoprazole in adolescent patients with gastroesophageal reflux disease (GERD). Gastroenterology 118 (4): 5683 Part 2 Suppl. 2 APR 2000.

71. Garhart CA, Heinzel FP, Nedrud JG, Czinn SJ: Interferon-gamma and NOS-2 are not required for reduction of bacterial load in immunized mice challenged with Helicobacter pylori SS1. Gastroenterology 120 (5): 3527 Suppl. 1 APR 2001.

72. Orenstein SR, Shalaby TM, Kosmack SN, Liacouras C, Czinn SJ, Simm TJ, Ahrens SP, Jiang K: Famotidine for infantile gastroesophageal reflux disease (GERD) part I: A randomized 4-week observer-blind trial of 2 doses. Gastroenterology 120 (5): 2225 Suppl. 1 APR 2001.

73. Blanchard TG, Nedrud J, Czinn SJ: Characterizing the contribution of genetics to Helicobacter-associated gastric inflammation by crossing inbred mouse strains that vary in pathology. Gastroenterology 122 (4): T1166 Suppl. 1 APR 2002.

74. Matsumoto Y, Blanchard TG, Czinn SJ: Increased inflammation and a reduced H-pylori load in the gastric mucosa of IL-10(-/-) mice: A role for inflammation in H-pylori immunity? Gastroenterology 122 (4): 67 Suppl. 1 APR 2002.

75. Song QS, Owens M, Pierce-Smith D, Czinn SJ, Sherman P, Gold BD: Antibiotic resistance of pediatric Helicobacter pylori. Gastroenterology 122 (4): 62 Suppl. 1 APR 2002.

76. Gutman R, Gerrek M, Seaman D, Siegel C, McNamara N, Czinn S, Blanchard SS: Catatonia presenting after liver transplantation in a teenager patient-successful management with electroconvulsive therapy. American Journal of Gastroenterology 97 (9): 433 Suppl. S SEP 2002.

77. Blanchard SS, Chelimsky G, Czinn S, et al.: Pyogenic granuloma of the colon in children. American Journal of Gastroenterology 97 (9): 331 Suppl. S SEP 2002.

78. Blanchard SS, Gerrek M, Czinn S, et al.: Food allergy with partial villous atrophy after pediatric liver transplantation with tacrolimus immunosuppression. American Journal of Gastroenterology 97 (9): 262 Suppl. S SEP 2002.


79. Gupta S, Gerrek M, Czinn S, et al.: N-acetylcysteine in non-acetaminophen induced acute liver failure in children. American Journal Of Gastroenterology 97 (9): 261 Suppl. S SEP 2002.

80. Drakes M, Blanchard TG, Czinn SJ: Probiotic modulation of dendritic cells. Gastroenterology 126 (4): A577-A577 Suppl. 2, 2004.

81. Anderson KM, Blanchard TG, Czinn SJ: Recruitment and activation of dendritic cells by Helicobacter pylori. Gastroenterology, 126 (4): A405-A406 Suppl. 2, 2004.

82. Basu M, Blanchard TG, Czinn SJ: Response of murine and human gastric epithelial cells to cag A-positive and -negative strains of Helicobacter pylori. Gastroenterology 126 (4): A403-A403 Suppl. 2, 2004.

83. Czinn S , Arora S, Blanchard S, et al.: Examination of fecal stream and mucosa-associated bowel flora in children with IBD: a methodologic approach. Gastroenterology 128 (4): A502-A502 Suppl. 2, 2005.

84. Anderson KM, Czinn SJ, Blanchard TG: Induction of energy in CD4-positive lymphocytes during Helicobacter pylori infection: Gastroenterology 128 (4): A130-A130 Suppl. 2, 2005.

MAJOR INVITED SPEECHES:

1. 2nd International Consensus Conference on Helicobacter PyloriTitle: What is the role for Vaccinations in Helicobacter Pylori.February, 1997; Bethesda, Maryland.

2. 4th Round Table Meeting on Helicobacter pyloriTitle: Immunological Determinants that may affect the H. pylori Cancer RiskFebruary, 1997; Miami, Florida.

3. Developments in Helicobacter Research: From the Basic Laboratory to the PatientPediatric Issues in H. pylori Infection (State of the Art Lecture)Moderator: Novel Drugs/Vaccines and WorkshopFebruary, 1997; St. Petersburg, Florida.

4. Cleveland Clinic GI Research ConferenceTitle: Helicobacter Pylori Infection and InflammationMarch 18, 1997

5. City Wide GI ConferenceTitle: The Role of H. pylori in the Pathogenesis of Peptic Ulcer DiseaseApril 14, 1997; Boston, Mass.

6. European Helicobacter Study GroupTitle: Immunopathogenesis of Helicobactor Pylori


September, 1997; Lisbon, Portugal.

7. GI Case Study Program for the Department of Family PracticeTopic: Case studies in the Management of Gastrointestinal DiseaseSeptember, 1997; Cleveland, Ohio.

8. Interscience Conference on Antimicrobal Agents and ChemotherapySymposia: Diagnosis and Therapy of Helicobacter Pylori InfectionSeptember, 1997; Toronto, Canada.

9. Royal Academy of Sciences - 2nd Annual Helicobacter Pylori MeetingVaccination to Prevent and Cure Helicobacter Pylori Injection (Keynote Address)December, 1997; London, England

10. Developments in Helicobacter Research: From the Basic Laboratory to the patientModerator: Novel Drugs/Vaccines WorkshopFebruary, 1998; Phoenix Arizona

11. American Gastroenterology AssociationModerator: Immunopathogenesis of H. pyloriMay, 1998; New Orleans, Louisiana

12. Current Controversies and Future Challenges in Acid-Related DisordersFaculty: H. pylori a Childhood InfectionMay, 1998; New Orleans, Louisiana

13. 5th Joint Meeting of the European and North American Society for Pediatric Gastroenterology and NutritionChairperson: H. pylori SessionKeynote Speaker: Immunopathogenesis of H. pyloriMay 1998; Toulouse, France

14. 3rd International Workshop on Pathogenesis and Host Response in Helicobacter InfectionChairperson: H. pylori VaccinesAbstract Review CommitteeJuly, 1998; Helsingor, Denmark

15. National Institute for Biological Standards and ControlInvited Lecture: H. pylori VaccinesJuly, 1998; London, England

16. XIth International Workshop; Gastroduodenal Pathology and Helicobacter pyloriInvited Speaker: Immunopathogenesis of H. pylori InfectionSeptember, 1998; Budapest Hungary

17. XIth International Workshop; Gastroduodenal Pathology in Helicobacter PyloriPlenary speaker: Immunopathogenesis of H. Pylori Infection,


September 1998; Budapest, Hungary.

18. Pediatric Research SeminarTitle: The Genetic Basis for Helicobacter Pylori Gastroduodenal DiseaseSeptember 1998. Rainbow Babies and Children’s Hospital.

19. Point and Counterpoint 1998, Clinical Challenges and Practical SolutionsInvited Speaker: Pediatric Gastroenterology – Children Are Not Little Adults,October 1998, Chicago, Illinois.

20. Grand Rounds. “Helicobacter pylori: A Disease of Childhood”Geisinger Health SystemOctober, 1998; Danville, Pennsylvania

21. Grand Rounds. “Helicobacter pylori: Infection and Host Immune Response”Suny Health Science CenterNovember, 1998; Brooklyn, New York

22. Canadian Helicobacter Pylori Study Group - Pediatric Consensus Group Title: Immune Responses to H. pylori InfectionNovember 1998, Victoria, British Columbia, Canada

23. Gastroenterology Advisory SummitInvited Lecture: Gastroesophageal Reflux Disease in the Pediatric Age GroupDecember 1998, Geneva, Switzerland

24. Developments and New Directions in Helicobacter Research: From the Basic Laboratory to the PatientChairperson: Vaccine Development in the Human Challenge ModelFebruary 1999, Orlando, Florida

25. American Society for Pediatric Gastroenterology and NutritionInvited Lecture: Clinical Guidelines for the Diagnosis & Treatment of Helicobacter pyloriOctober 1999, Denver, Colorado

26. Helicobacter Pylori: Basic Mechanisms to Clinical Cure 2000Invited Lecture: Immune Inflammatory Response in H. pylori in ChildrenMarch 2000, Bermuda

27. World Congress of Pediatric Gastroenterology, Hepatology & NutritionInvited Lecture: Molecular Pathophysiology of H. pylori DiseaseAugust 2000, Boston, Massachusetts

28. XIIIth Belgian Week of GastroenterologyInvited Lecture: Immunobiology of H. pylori: Implications for TherapyMarch 2001, Knokkee, Belgian


29. Cancer Center/Blood Club SeminarInvited Lecture: Helicobacter Pylori: A Cause of Gastric AdenocarcinomaMarch 2001, Cleveland, OH

30. Pediatric Academic Societies’ Annual MeetingInvited Speaker: The Diagnosis & Treatment of Helicobacter Pylori InfectionMay 2001, Baltimore, MD

31. International Symposium of Pediatric Gastroenterology, Hepatology & NutritionInvited Speaker: Immunobiology of H. pylori Implications for Therapy and VaccinesJune 2001, Montreal, Canada

32. Pediatric Crohn’s Disease and Ulcerative ColitisInvited Speaker: Current Pediatric IBD Research InitiativesOctober 2001, Cleveland, OH

33. Grand Rounds: “Helicobacter Pylori Gastroduodenal Disease”University Hospitals of Cleveland.November 2001, Cleveland, OH

34. Grand Rounds: “Pediatric Inflammatory Bowel Disease”MetroHealth Medical CenterNovember 2001, Cleveland, OH.

35. New Approaches to Bacterial Vaccine Development Invited Speaker: Vaccine Development for Helicobacter pyloriMay 2002, Munich, Germany

36. 5th International Workshop on Pathogenesis and Host Response in Helicobacter InfectionsInvited Speaker: Plenary Session: Neonatal Immune SystemJuly 2002, Lo-Skolen, Helsingor, Denmark

37. Pediatric Gastroenterology, Hepatology and Nutrition: Ninth Annual Postgraduate Course Invited speaker: H. pylori Gastritis should be Treated in Children with RAPOctober 2002, San Antonio, TX

38. North American Society of Pediatric GastroenterologyInvited Speaker: Defining New Standards for the Treatment of Pediatric Acid Related DisordersOctober 2002, San Antonio, TX

39. Pediatric Crohn’s Disease and Ulcerative ColitisInvited Speaker: New Research Initiatives in Pediatric IBDNovember 2002, Cleveland, OH


40. Pan American Health Organization Centennial Vaccine Conference: A Vision for the FutureInvited Speaker: Helicobacter pylori Vaccine DevelopmentNovember 2002, Washington DC

41. H. pylori Infection in ChildrenGrand Rounds: Cleveland Clinic FoundationDecember 2002, Cleveland, OH

42. XVIth International Workshop: Gastrointestinal Pathology and Helicobacter Plenary Address: Future of a Helicobacter VaccineSeptember 2003, Stockholm, Sweden

43. Helicobacter pylori: Infection, Inflammation and Host Immune Response Grand Rounds: University of MarylandDecember 2003, Baltimore MD

44. World Congress of Pediatric Gastroenterology and NutritionTitle: Sharing Solutions in Pediatric GastroenterologyInvited Speaker: Management of a Child with Possible GERD – Related Asthma Symptoms2004, Paris, France

45. The Future of a Helicobacter VaccineBeyond the Human Challenge ModelInvited Speaker: The Host Immune Response to H. pyloriSeptember 2005, Berlin, Germany

46. 5th Western Pacific Helicobacter CongressInvited Speaker: Prospects for a Vaccine to Prevent Helicobacter pylori InfectionJanuary 2005, Japan

47. Canadian Helicobacter Study Group Annual MeetingInvited Speaker: Pediatric Perspective of Helicobacter InfectionSeptember 2005, Montreal Canada

48. G. Bowers Mansdorfer Lectureship in PediatricsInvited Speaker: Probiotics: The Chicken Soup of the 21st Century?October 2006, Baltimore, Maryland

49. Microbiology & Immuniology Seminar SeriesInvited Speaker: Helicobacter pylori: Infection, Inflammation and Host Immunie ResponseMay 2007, Baltimore, Maryland