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This is the presentation depicting the major catabolic effects and the various hormones responsible for increasing the concentration of Glucose in blood stream in times of stress and starvation.
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Regulation of Blood Glucose(Part-II)
Dr. Abhishek RoyJR, Dept. of Biochemistry
Grant Govt. Medical College andSir JJ Group of Hospitals, Mumbai
Email: [email protected]
Dr. Abhishek Roy
Dr. Abhishek Roy
Main effects of Growth Hormone
Dr. Abhishek Roy
Main effects of Epinephrine
Dr. Abhishek Roy
Main effects of Glucocorticoids
Dr. Abhishek Roy
Dr. Abhishek Roy
Dr. Abhishek Roy
Enzyme induction and repression by Glucagon
Glu-6-Pase +Fruc-1,6- BPase +PEPCK +Glucokinase -PFK-1 -Pyruvate Kinase -
Dr. Abhishek Roy
Dr. Abhishek Roy
PEPCK• As PEPCK acts at the junction between glycolysis and
the Krebs cycle, it causes decarboxylation of a C4 molecule, creating a C3 molecule. • As the first committed step in gluconeogenesis, PEPCK
decarboxylates, and phosphorylates oxaloacetate (OAA) for its conversion to PEP, when GTP is present.• Transcription of the PEPCK gene is stimulated by
glucagon, glucocorticoids, retinoic acid, and adenosine 3’,5’-monophosphate (cAMP), while it is inhibited by insulin.
Dr. Abhishek Roy
Dr. Abhishek Roy
Dr. Abhishek Roy
Dr. Abhishek Roy
Dr. Abhishek Roy
Dr. Abhishek Roy
Dr. Abhishek Roy
Variation in glucose phosphorylating activity of hexokinase and glucokinase with increasing blood glucose concentration. The Km for glucose of hexokinase is 0.05 mmol/L and of glucokinase is 10 mmol/L.
Dr. Abhishek Roy
Dr. Abhishek Roy
Dr. Abhishek Roy
Control Of Glycogen Synthase in muscle
Dr. Abhishek Roy
Control of Phosphorylase in Muscle
Dr. Abhishek Roy
Dr. Abhishek Roy
Cori’s Cycle (Lactate Cycle) and Glucose-Alanine Cycle
Dr. Abhishek Roy
Phosphorylase in Liver and Muscles• Role of glycogen is to provide free glucose for export
to maintain the blood concentration of glucose
Dr. Abhishek Roy
Triacylglycerol metabolism in adipose tissue. Hormone-sensitive lipase is activated by ACTH, TSH, glucagon, epinephrine, norepinephrine, and vasopressin and inhibited by insulin, prostaglandin E1 , and nicotinic acid.
Lipolysis
Dr. Abhishek Roy
Lipolysis
Dr. Abhishek Roy
Ketogenesis
Dr. Abhishek Roy
