H. pyloriSeropositivity before Age 40 and SubsequentRisk of Stomach Cancer: A Glimpse of the True

Relationship?

Sreejith Ben csSreejith Ben csU3BIT12051U3BIT12051

IntroductionIntroduction

people don’t know about this silent people don’t know about this silent infeinfection until they start suffering from gastction until they start suffering from gastritis or the painful effects of ulcersritis or the painful effects of ulcers..Its presence is hard to detecIts presence is hard to detect.t.Spreads through the consumption of Spreads through the consumption of contaminated food and water. contaminated food and water.

superficial gastritis

atrophic pangastritisintestinal metaplasia and associated hypochlorhydria

chronic inflammation of the lamina propria, limited to the outer third of the mucosa

a process of chronic inflammation of the stomach mucosa,

an intermediate precancerous gastric lesion in the gastric cancer cascade from chronic gastritis

chronic atrophic gastritis, occurring at a much higher rate in infected destroys the microorganism’s natural niche and may lead to disappearance of H. pylori ,resulted in underestimation of the strength of the association

90%

Swedish Institute for Infectious Disease Control Biobank (since1957)

investigations of the immunity against infections in the Swedish population samples that have been analyzed stored at 22 'C.samples from 93 462 unique individuals (with validNational Registration Numbers [NRNs]between age 16-40

Malmo¨ Microbiology Biobank (since 1969).

majority of the samples are submitted for diagnosis of blood-borne viral infections, e.g. hepatitis virus, (over 500,000 samples). About100,000 samples emanate from population-basedserological screening for viral infections and rubella immunityduring pregnancy.samples from 374 598 uniqueindividuals (with valid NRNs) collected between age 16 and 40

case-control study of about 400 000 individuals

Results :

Compared with the ‘clean’ reference group, those seronegative for both Hp-CSA and CagA antibodies,subjects seropositive with either Hp-CSA or CagA antibodies hada close to 10-fold increased risk (95% CI 2.9–32.9), and theincreased risk further rose to close to 50-fold among thoseseropositive with both antibodies (95% CI 5.8–407.4).

H. pyloriwas classified as a class I carcinogen forstomach cancer by the International Agency for Research onCancer (IARC)

H. pylori have beenshown to promote the production of inflammatory mediators suchas IL-1 and TNF-a, both potent suppressors of stomach juicesecretion.

resulting in enhanced inflammation in the mucosa of the corpus, followed by parietal celldestruction and irreversible Hypochlorhydria "

Discussion