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What beyond Genetics is playing here?

?EPIGENETICS

Epigenetics: Basic Conceptand Its Relationship withDevelopment and Cancer

Speaker,Dr. Md. Mohiuddin MasumMS Anatomy, Phase-A, Year-1, Block-1

Guided by,Prof. K M ShamimProfessor, Dept. of Anatomy, BSMMU

“• Define epigenetics

• Describe important epigenetic mechanism and explain the implication of epigenetics in normal functions, disease and disease presentation

Objective

“• Outline the heritability or epigenetic effects

• Explain the role of epigenetic in the development of cancer

• Outline the potentials of epigenetic intervention in battling cancer

Objective(contd.)

Epigenetics

Epi + Genetics

Heritable changesin gene expressionthat operate outside ofchanges in DNA itself

Chromosome Structure

Purines Pyrimidines

Chromosome Structure (contd.)

DNA Methylation

Histone Modification

ac

me

Pubacclt

Acetylation

Methylation

Phosphorylation

Ubiquination

Deimination

microRNA

Genetics

EnvironmentBehavior

Nutrition

Inactivation of X-chromosome

Barr Body

Differention of Pluripotent Stem Cells to Somatic Cells

Genomic ImprintingWorking set Imprinted set

(and thus silenced)Working set Imprinted set

(and thus silenced)

Combination- 1 Combination- 2

Normal

Non-working set Imprinted set(and thus silenced)

Non-working set Imprinted set(and thus silenced)

Father’s gene is imprinted (silenced)Mothers gene is mutated (non-working)

Mother’s gene is imprinted (silenced)Father’s gene is mutated (non-working)

Prader-Wili syndrome Angelman syndrome

♀ ♂ ♀♂

♀ ♂ ♀ ♂

Mother: 1st Generation

Fetus: 2nd Generation

Germ cells: 3rd Generation

Epigenetics

Genetics

Hyperm

ethyla

tion

Hypometh

ylatio

n

Battling Cancer Using Epigenetics

Battling Cancer Using Epigenetics

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