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A training session for using TOXNET
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TOXNETTOXNET
Toxicology and Environmental Toxicology and Environmental Health Information on the InternetHealth Information on the Internet
National Library of MedicineNational Library of Medicine
What is What is TOXNETTOXNET??
System of databasesSystem of databases
Information about toxicology, environmental health, Information about toxicology, environmental health, hazardous chemicals, and toxic releaseshazardous chemicals, and toxic releases
Developed by the National Library of Medicine Developed by the National Library of Medicine (NLM)(NLM)
http://toxnet.nlm.nih.gov/http://toxnet.nlm.nih.gov/
Types of FilesTypes of Files
DataData Literature (bibliographic)Literature (bibliographic) Chemical DictionaryChemical Dictionary Toxic Release InventoryToxic Release Inventory
Related: TOXMAP, TOXTown (consumer), Related: TOXMAP, TOXTown (consumer), PubMedPubMed
TOXNET TOXNET Data FilesData Files
There are 5 of themThere are 5 of them
Click the Click the ??
for additional for additional information about each information about each databasedatabase
Data FilesData Files
HSDBHSDB – Hazardous Substances Databank – Hazardous Substances Databank CCRISCCRIS - Chemical Carcinogenesis Research - Chemical Carcinogenesis Research
Information SystemInformation System GENTOXGENTOX – Mutagenicity studies (not – Mutagenicity studies (not
updated)updated) IRISIRIS – Integrated Risk Information System – Integrated Risk Information System ITERITER - International Toxicity Estimates for - International Toxicity Estimates for
Risk AssessmentRisk Assessment
Hazardous Substances Data BankHazardous Substances Data Bank((HSDBHSDB))
Online handbook compiled by NLMOnline handbook compiled by NLM 1 record per chemical1 record per chemical 5,000 + records5,000 + records Human and animal toxicityHuman and animal toxicity Safety and handlingSafety and handling Human health effectsHuman health effects Emergency medical treatment guidelinesEmergency medical treatment guidelines
Chemical Carcinogenesis Research Chemical Carcinogenesis Research Information System (Information System (CCRISCCRIS))
National Cancer Institute (NCI) dataNational Cancer Institute (NCI) data 9,000 + chemical records9,000 + chemical records Carcinogenicity studiesCarcinogenicity studies Tumor inhibition studiesTumor inhibition studies Tumor promotion studiesTumor promotion studies Mutagenicity studiesMutagenicity studies
Searching Data FilesSearching Data Files
Search all databases, orSearch all databases, or Select one database, orSelect one database, or Search “Multi-Database” to search just the Search “Multi-Database” to search just the
data filesdata files
Content areasContent areas of interest in of interest in HSDBHSDB
Human Health EffectsHuman Health Effects Emergency Medical TreatmentEmergency Medical Treatment AntidotesAntidotes Physical & chemical propertiesPhysical & chemical properties InteractionsInteractions Environmental fate & exposureEnvironmental fate & exposure ManufacturersManufacturers Uses: therapeutic, business, etc.Uses: therapeutic, business, etc.
TOXNET’s TOXNET’s 22 Literature Files Literature Files
TOXLINETOXLINE
TOXLINE Core – in PubMed, accessible TOXLINE Core – in PubMed, accessible through TOXNETthrough TOXNET
Search in PubMed via TOXLINE subset LimitSearch in PubMed via TOXLINE subset Limit PubMed Features:PubMed Features:
MESHMESH LimitsLimits MyNCBI, MyNCBI, See Related Articles, LinkOutSee Related Articles, LinkOut
TOXLINETOXLINE
TOXLINE Special – in TOXNET TOXLINE Special – in TOXNET onlyonly Both Core and Special can be searched in Both Core and Special can be searched in
TOXNETTOXNET
TOXNET Features:TOXNET Features: Search both Core and SpecialSearch both Core and Special Relevancy RankingRelevancy Ranking Link to other TOXNET databasesLink to other TOXNET databases
TRI:TRI: Toxics Release InventoryToxics Release Inventory
EPA information regarding the release of EPA information regarding the release of certain toxic chemicals certain toxic chemicals
Reporting is mandated by law and does Reporting is mandated by law and does notnot cover cover allall industries or industries or allall businesses businesses
Release years 1987 – data available in Release years 1987 – data available in TOXNET. Also available through EPA TOXNET. Also available through EPA websitewebsite
TRI TRI
Facility IdentificationFacility Identification Substance IdentificationSubstance Identification Environmental releaseEnvironmental release Waste treatment (on & off site)Waste treatment (on & off site) Source reduction and recyclingSource reduction and recycling
Searching TRISearching TRI
Search by chemical name or CAS
Specify release amount and type
Select a year or years
Search by facility name
Search by location
Search by SIC code
Mapping resultsMapping results
This button provides This button provides mapping capabilitiesmapping capabilities
Use it to see where the Use it to see where the releases in question releases in question were locatedwere located
ChemIDplusChemIDplus
Chemical dictionary/directory fileChemical dictionary/directory file Two versions: “Lite” & AdvancedTwo versions: “Lite” & Advanced 379,000 + chemical records379,000 + chemical records 257,000 + structural records257,000 + structural records
In the Advanced file onlyIn the Advanced file only Requires JAVA or CHIME software (free)Requires JAVA or CHIME software (free)
Direct link to other resourcesDirect link to other resources
ChemIDPlus VersionsChemIDPlus Versions
Lite:Lite: basic search of the chemical name, basic search of the chemical name,
registry numberregistry number Results screen allows you to search other Results screen allows you to search other
databases, and view information: basic, databases, and view information: basic, full, names, formulas, classification full, names, formulas, classification codes, registry numbers, notescodes, registry numbers, notes
ChemIDPlus VersionsChemIDPlus Versions
Advanced:Advanced: Advanced searching on chemical name, registry Advanced searching on chemical name, registry
number, molecular formula, classification code, number, molecular formula, classification code, toxicity, chemical property, chemical structure, toxicity, chemical property, chemical structure, molecular weightmolecular weight
Refine search with “similarity” percentagesRefine search with “similarity” percentages View and draw structures with special software View and draw structures with special software
such as Marvin, Chimesuch as Marvin, Chime Results screen provides all features of Lite plus Results screen provides all features of Lite plus
structure (can be 3D)structure (can be 3D)
Searching ChemIDplusSearching ChemIDplus
Search by chemical Search by chemical name or CAS Registry name or CAS Registry NumberNumber
Click on “search” to Click on “search” to retrieve results from the retrieve results from the “Lite” version“Lite” version
Use the Advanced Use the Advanced button to access the button to access the Advanced capabilitiesAdvanced capabilities
Advanced SearchingAdvanced Searching
Search by:Search by: SubstanceSubstance Toxicity rangesToxicity ranges Physical propertiesPhysical properties StructureStructure Molecular weightMolecular weight
NOTE: Results look the same. Differences are NOTE: Results look the same. Differences are searching and structuresearching and structure
Household Products DatabaseHousehold Products Database
Environmental Consumer Health informationEnvironmental Consumer Health information
Search for environmental effects of common Search for environmental effects of common household itemshousehold items
Categories: auto, pesticides, personal care, arts Categories: auto, pesticides, personal care, arts and crafts, home, landscape/yard, home and crafts, home, landscape/yard, home maintenance, pet care maintenance, pet care
TOXTOWNTOXTOWN
Environmental consumer health in everyday Environmental consumer health in everyday situationssituations
HaxMapHaxMap
Links jobs and hazardous tasks with Links jobs and hazardous tasks with occupational diseases and symptomsoccupational diseases and symptoms
Might NOT want to show this to students as Might NOT want to show this to students as they determine career direction!! they determine career direction!!