MPHARM PART 2 RECENT SEMINAR
UV CURABLE GEL FORMULATIONS as
drug carriers
PRESENTED BY
SUBODH S SATHEESH2ND MPHARMECPS
.
Hello!
I am SubodhHearty welcome to my presentation
UV CURABLE GELS
Let’s start with the first set of slides
“Nail diseasesAffects the quality of lifeTopical and oral antifungalsAdverse effects and
contraindications
TOPICAL AGENTS
×Overcomes the disadvantages×Needs to be frequently applied×Poor patient complaince
Currently used as cosmetics
Glossy cosmetically acceptable film
Topical drug carriers Increases drug
residence Increases patient
complaince
UV curable gels
Materials
×Drug×Base Resins
eg…urethene methaacrylate×Photoinitiators
eg….alpha hydroxy ketone×Additives
eg…pyromellitic glycerol×Rheology Modifiers
eg…bentonite
……….
×Drug used amorolfine HCl and terbinafine HCl×Base resin..dimethyl acrylate×Solvent inclusion for effective drug loading×Ethanol and NMP(n methyl 2 pyrollidine)
Proportion ofexcipients
Concentration of photoinitiators and base resins were used as similar as cosmetic gels
Formulation with ethanol in 25 to 50%
Increased water sensitivity and decreased drug residence
Inclusion of ethanol at 25% produced 3%AF and 4% TF and NMP Produced 1% of each
Preaparation of formulations
×Three types of formulation
Drug free solvent
containing formulations
Drug free solvent free formulation
Drug and
solvent
UV curing of formulations
× Formulation was applied to a microscope glass slide using pipette tip× Placed under a UV nail lamp× Curing of formulation and formation of film× Surface wiped with propanol× Glossy film× Mass conversion percentage
Wt/W0*100
Characterisation of uv cured film
ThicknessAK9635D 0–25 mm Digital External Micrometer
Maximum drug loadXRD and polarised light microscopy
DSCQ2000TA
SEMFEI Quanta 200F.
TGADiscovery TGA model
DMAQ800DMA
…
× Uv cured films adhesivity× Sensitivity to water× Drug release from films× Invitro drug permeation studies× Analytical methods × .
RESULTS
...
THICKNESS
..Solvent-free and drug-free gel 211.1 _ 6.0
Drug-free gel containing ethanol 161.1 _ 7.8
Gel containing ethanol and 3% w/v Amorolfine HCl 163.3 _ 8.7
Gel containing ethanol and 4% w/v Terbinafine HCl 164.4 _ 7.3
Drug-free gel containing NMP 165.6 _ 7.3
Gel containing NMP and 1% w/v Amorolfine HCl 167.8 _ 8.3
Gel containing NMP and 1% w/v Terbinafine HCl 166.7 _ 7.1
Drug-free gel containing ethanol 161.1 _ 7.8
Percentage of conversion
.. Solvent-free and drug-free gel 51.3
Drug-free gel containing ethanol 61.1
Gel containing ethanol and 3% w/v Amorolfine HCl
61.4
Gel containing ethanol and 4% w/v Terbinafine HCl
59.9
Drug-free gel containing NMP 62.7
Gel containing NMP and 1% w/v Amorolfine HCl
63.7
Gel containing NMP and 1% w/v Terbinafine HCl
60.9
Drug-free gel containing ethanol 59.4
SEM RESULTS
…
Mass after UV curing
× Mass yield and drug yield
FTIR
× No interactions× NMP’s incorporation
into polymer has produced C=O strech
× Ethanol have no effect
DMA Results
. × Two transitions represent two polymer chains
× Reaction of monomers× In NMP more residual
solvent has produced plasticizing effect on UV cured film
× Low Tg value
Film adhesion to substrate
.. × High scores shows low adhesion
× Ethanol dont make much change
× NMP reduces adhesivity× More NMP on curing
Water sensitivity values
. × NMP formulations are extremely water sensitive
× Incorporation of NMP in the polymer
× Low water sensitivity of ethanol
× Low water sensitivity ensures longer residence on nail
Stability
× Accelerated stability studies
× 3months× No changes for
uv films× Polymer films
produced crystals
Drug release
× Curanail is commercially available nail lacquer
× Curanail produced complete drug release by day 10
× Uv curable produced slow release which indicates greater affinity to films.
CONCLUSIONS
× Promising topical drug carriers× Ethanol containing formulations have high stability
and water resistance× Improves topical therapy of nail diseases
× .
REFERENCES
Stephen Hilton, laxmi R, Sudaxshina Murdan. UV-curable gel formulations: Potential drug carriers for the topical treatment of nail diseases. Intl J pharmacy, 2015, 177˗190
Thomas B, Chemistry and Formulation of UV curable gel formulations. Esstech.In 2014 page 234to240
Marjo K Uv curable gel formulations. Tamper J of App Sci. 2011:1(3) 1˗28
Kentaro T, Effects of Curing Conditions and Formulations on Residual Monomer Contents and Temperature Increase of a Model UV Gel Nail Formulation. Journal of Cosmetics, Dermatological Sciences and Applications, 2011, 1, 111-118
Mianz K Uv curable gels in cosmetics. J of cosmetics. 2013,13˗21×.
Thanks!.