Team Members:Team Leader- Adam GoonBSAC- Mike ConrardyBWIG- Andrew BertramCommunicator- Joel Webb
Advisor- Professor John WebsterClient- Tim Hacker, PhD
Background Information Problem statement Design Requirements Stem cell injections Design Alternatives
◦Balloon◦Multiple Needle◦Guided
Design Matrix Proposed Design Future Work
Left Ventricle
http://www.thefinalsprint.com/2007/02/heart-health-and-marathon-running-preparation-is-key/
• Current research is being conducted injecting stem cells into dead heart tissue.
• Research is done using pigs.
• The catheter being used currently has a single needle on the tip and must be moved for every injection site.
•2.7 mm diam, 27 gauge needle, 4 to 6 mm depth of needle
• Current Devices• Myostar by Biosense-Webster•Stiletto by Boston Scientific
Time consuming◦Reposition the catheter◦Single injection◦Heart is beating◦Difficult to position
Needle depth is inconsistent
Flexibility
http://www.med.upenn.edu/mcrc/patel_lab/documents/LVCatheterUsingEtOHinSwineJICE.pdf
Multiple, quick injection◦>1 injection per catheter location
Small enough for arteries◦ < 14 French diameter (4.66 mm)
Flexible to get through aorta Consistent depth of needle Accurately position the device
Inject contrast agent Take still image and mark contrast agent Insert injection catheter Determine placement and protrude needle Observe electrical activity of heart on ECG
Insertion of needle causes increase in activity
Wait for activity to stabilize Stop ventilator for injection Inject stem cells
#1 Two layers◦Polyethylene
Terephthalate◦Rubber tubing
◦Needles attached to rubber exterior
Fills most of ventricle
Simultaneously injects stem cells to large area
#2 Multiple needle catheter◦Preformed needle shape◦Single location◦Simultaneous injection
Similar to an ablation catheter
http://www.angiodynamics.com/pages/products/starburst_talon.asp
#3, 3 components Slotted outer
component Track for guidance Inner needle injection
catheter
Outer component rests against apex of heart
Use holes for multi-level injections using preformed curved catheter
Cost(0.05)
Time Reduction (0.30)
Accuracy of Injection (0.30)
Flexibility (0.05)
Ease of Manufacturing (0.30)
Total
#1 Balloon
1 (0.05)
9 (2.7)
4 (1.2)
8 (0.4)
1 (0.3)
4.65
#2Guided
5 (.25)
7 (2.1)
8(2.4)
5 (.25)
4(1.2)
6.2
#3 Multiple Needle
7 (.35)
4 (1.2)
6 (1.8)
6 (.3)
8 (2.4)
6.05
360o movement of exterior component
Predetermined angle of injection
Track moveable to different holes through handle◦ Screw mechanism◦ Full turn causes track to
move to next hole
Contact companies for guidance on development
Finalize design of handle
Improve consistency of depth of needle
Create prototype and conduct testing
http://www.madehow.com/Volume-6/Angioplasty-Balloon.html http://www.angiodynamics.com/pages/products/starburst_talon.asp Callans, D.J., Ren, J.F., Narula, N., Patel, V., Michele, J., Gelzer, A., Dillon, S.M. Left Ventricular
Catheter Ablation using Direct, Intramural Ethanol Injection in Swine. Journal of Interventional Cardiac Electrophysiology, 6, 225–231.
http://www.thefinalsprint.com/2007/02/heart-health-and-marathon-running-preparation-is-key/