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Team Members:Team Leader- Jeremy GlynnCommunicator- Jeremy SchaeferBSAC- Mike ConrardyBWIG- Adam Goon
Client- Ian Rowland, Ph.D., Department Of RadiologyAdvisor- Professor Bill Murphy
Background Information Problem Statement Motivation Client Requirements Existing Technology Design Alternatives Design Matrix Future Work Questions?
Basics of MRI (Magnetic Resonance Imaging)◦ Generates very strong (4.7 T) magnetic field◦ Causes atoms to emit radiowaves
Uses of MRI:◦ MR images provides information such as:
Size of tumors Functions of organs Chemical concentrations
◦ Client’s focus – Brain imaging
http://en.wikipedia.org/wiki/Magnetic_resonance_imaging
MRI Coil for imaging ratsCaptured 2/5/08, UW Hospital
Design a stereotactic device that will:◦ Minimize head movement of rats/mice
while positioned in MRI◦ Incorporate a heating device to
prevent hypothermia◦ Fit within the MRI coil◦ Allow for provided anesthetic
Imaging quality and efficiency◦ Allow for imaging over a longer time period
Animals metabolic rates decrease with anesthesia Can lead to hypothermia or death
◦ Anesthetic can be connected quickly and easily◦ Animal can be positioned with ease
Animal safety◦ Current heating methods are inadequate
Can’t interfere with MRI images Animals brain must be centrally aligned in MRI Heating device to warm animal
◦ Within 5o of 37oC Fit inside MRI coils
◦ Rat- 63 mm diameter◦ Mouse-36 mm diameter
Anesthetic mask must cover animals mouth Minimal movement of animal
◦ Restraint without harm Withstand 4.7 Tesla magnetic field
David KOPF Instruments◦ Model 324 MRI Head Holder for Rat◦ Model 325 MRI Head Holderfor Mouse◦ Model 923M MRI Mouse Gas Anesthesia Adaptor Enzyme Research Facility
http://www.kopfinstruments.com/Stereotaxic/StereotaxicPrintables/324-325-P.pdf
Enzyme Research Facility (Beth Rauch)
Tooth restraint does not obscure anesthetic mask.
Fits inside MR tray Recessed in tray for proper brain alignment.
Advantages◦ Inexpensive
Disadvantages◦ Difficult to move
heated air efficiently◦ Air has less effective
heat transfer◦ Larger volume of air
to heat
Advantages◦ Easy to manufacture◦ Water has better
thermal conductivity◦ Accessory parts
inexpensive Disadvantages
◦ 3D printing expensive
◦ Possibility water could leak
Advantages◦ Easy to manufacture◦ No possibility of leaking water
Disadvantages◦ Air has low thermal conductivity◦ Difficult to move heated air through small
diameter tube
Cost (0.05)
Durability (0.20)
Heat Consistency- Quality of Circulation (0.30)
Heat Transfer - Efficiency (0.25)
Ease of Manufacturing (0.20)
Total
Air Chamber
8 (.4) 8 (1.6) 4 (1.2) 6 (1.5) 6 (1.2) 5.9
Fluid Piping
5 (.25)
7 (1.4) 9 (2.7) 8 (2) 7 (1.4) 7.75
Air Piping 6 (.3) 8 (1.6) 7 (2.1) 5 (1.25) 6 (1.2) 6.55
Research:◦ Pumping/Heating design
Start up time Efficiency
Testing:◦ Heat lost through piping◦ Durability of 3D printing material◦ Temperature of heating pad◦ Temperature of fluid