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EMD Millipore is a division o Merck KGaA, Darmstadt, Germany
Trusted expertise
through every phase.Simpliy your outsourcing decisions –choose EMD Millipore as your service partnerrom discovery through development.
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Featuring
As a leading innovator in ow cytometry technologies and services, EMD Millipore
understands the power o in-depth cell analysis or research and pharmaceuticaldevelopment. We combine our custom assay development, assay validation, and sample
processing capabilities with the most clinically established platorm, the BD FACSCanto™ II.
Our service portolio includes immunophenotyping, detection o intracellular and
extracellular markers, antigen binding assays and more.
Benefts:
• A powerul, exible analytical tool or drug efcacy measurement
•Scientifc expertise rom optimized sample preservation to robust validation
•Extensive data interpretation and processing
Learn more at www.emdmillipore.com/biomarkerservices
UbiquitinProfler™ Service removes the complexity o ubiquitin pathway drugdevelopment, and is the only service that enables you to explore the complete
ubiquitination cascade, including E3 ligase activity.
Benefts:
• Functional screening and profling assays or an expanding panel o E3 ligase cascades
to screen and profle inhibitors and enhancers
•Cascades consists o E1, E2 and E3 enzymes and biologically relevant substrates
•Led by the same experts who have run KinaseProfler™ services or over 10 years
Also available: related E1, E2, E3 and substrate products or unctional assays
Learn more at www.emdmillipore.com/ubiquitin
UbiquitinProfler™ Services
NEW! Flow Cytometry Assay Services
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Pre-ClinicalHTS & Lead Discovery Phase 1 Phase 2 Phase 3 LaunchTarget Validation
Our service expertise spans the drug discovery process.
Screening and ProflingServices
Biochemical and cell-based
unctional assays or kinase, GPCR,
ion channel and ubiquitination
targets ● Proling services ●
Customized solutions through
assay development.
In Vitro Toxicity Studies
Industry-leading, unctional
proling against 125 GPCR, kinase,
phosphatase and ion channel targets.
Cell-Based Assay Services
GPCRProler® and IonChannelProler™ services integrate EMD Millipore’s stable GPCR and ion channel cell line products into unctional assays or small and large molecule
potency and selectivity proling ● GxP-compliant services or testing neutralizing antibody assays during tiered immunogenicity testing and in potency and stability testing
o biotherapeutics.
Biomarker Analysis Services
Protein and nucleic acid biomarker analysis ● RIA, ELISA, Luminex® xMAP® technology, electrochemiluminescence (ECL), Gyrolab® and fow cytometry services using the EMD Mill ipore portolio o assays or commercially
available kits rom any vendor ● Transer, develop and validate custom assays to meet your requirements ● Exploratory and GxP nucleic acid analysis using the latest qPCR and Pyrosequencing® instrumentation.
Biopharmaceutical Analysis Services
Experienced development and perormance o cell-based potency and l igand binding assays or impurity testing, batch
release and testing o stability samples ● Claim compliance to GMP or regulatory submission or as a non-regulatory study
under the same high quality standards ● Wide range o cell-based assays (e.g. ADCC, cell prolieration, receptor binding)
and ligand binding techniques including ELISA/RIA, Luminex® xMAP® Technology, surace plasmon resonance (Biacore™), ECL
and immunoblotting.
Pharmacokinetic Services
Industry-leading experience in the development and validation o PK/TK assays or the measurement o large molecules
and peptides ● Scalable solutions to meet your specic needs, rom routine sample analysis through to ull-service assay
development and validation.
Immunogenicity Services
Adhering to current FDA and EMA guidelines and AAPS white papers, we ollow a stepwise approach to measure anti-drug
antibody responses using ELISA/RIA, surace plasmon resonance, GyroLab®, ECL, DELFIA® and Nab analysis using cell-based
assays ● We transer, develop and validate methods and evaluate several platorms to ensure optimal data quality ● With
unsurpassed industry experience, EMD Millipore provides the technical expertise, quality assurance and peace o mind
that are essential when considering a partner or research, preclinical through to clinical regulated assay development and
sample analysis on any scale.
www.emdmillipore.com/discdev
From discovery throughdevelopment.
EMD Millipore is your premier service provider or
condently advancing your drug pipeline rom discovery
to market. We extend your capabilities by combining our
scientic knowledge, regulatory expertise and fexibility,
with the trusted, relevant inormation required or your drug
discovery and development needs.
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www.emdmillipore.com/discdev
EMD Millipore, the M Mark, KinaseProfler, IonchannelProfler and UbiquitinProfler are
trademarks o Merck KGaA, Darmstadt, Germany. GPCRProfler is a registered trademark o
Merck KGaA, Darmstadt, Germany. Luminex and xMAP are registered trademarks o Luminex
Corporation. Biacore is a trademark o GE Healthcare Biosciences AB. Gyrolab is a registeredtrademark o Gyros AB. DELFIA is a registered trademark o PerkinElmer, Inc. Pyrosequencing is a
registered trademark o Qiagen. FACSCanto is a trademark o BD Biosciences.
Lit code # PF3332EN00 Rev. A DD SBU-12-06547 ROSE
9/2012 ©2012 EMD Millipore Corporation, Billerica, MA USA. All rights reserved.
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