Matrix metalloproteinases (MMPs) & Role in Angiogenesis

Vijay Avin BR, Molecular Biomedicine Laboratory, Sahyadri Sceince College, Shimoga, Karnataka, India

• A protease (also termed peptidase or proteinase) is any enzyme that performs proteolysis, that is, begins protein catabolism by hydrolysis of the peptide bonds that link amino acids together in the polypeptide chain forming the protein.

Catalytic residue

– Serine proteases – Threonine proteases – Cysteine proteases – Aspartate proteases – Glutamic acid proteases

– Metalloproteases - using a metal, usually zinc

• Matrix metalloproteinases (MMPs) are a large family of calcium-dependent zinc-containing endopeptidases.

• which are responsible for the tissue remodeling and degradation of the extracellular matrix (ECM), including collagens, elastins, gelatin, matrix glycoproteins, and proteoglycan.

• Matrix metalloproteinases are excreted by a variety of connective tissue and pro-inflammatory cells including fibroblasts, osteoblasts, endothelial cells, macrophages, neutrophils, and lymphocytes.

Transduction of MMPs

Involvement of MMPs in physiological and pathologicalprocesses

Activation of MMPs leads to........

MMps in Pathological condition....

MMPs and cancer

Angiogenesis and MMPs

Angiogenesis and MMPs Contd.....

Wat happnes with in the blood vessels?? MMPs in blood vessels