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Matrix metalloproteinases (MMPs) & Role in Angiogenesis Vijay Avin BR, Molecular Biomedicine Laboratory, Sahyadri Sceince College, Shimoga, Karnataka, India

matrix metallo proteases (MMPs)

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MMPs Overview By Vijay Avin BR

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Page 1: matrix metallo proteases (MMPs)

Matrix metalloproteinases (MMPs) & Role in Angiogenesis

Vijay Avin BR, Molecular Biomedicine Laboratory, Sahyadri Sceince College, Shimoga, Karnataka, India

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• Matrix metalloproteinases (MMPs) are a large family of calcium-dependent zinc-containing endopeptidases.

• which are responsible for the tissue remodeling and degradation of the extracellular matrix (ECM), including collagens, elastins, gelatin, matrix glycoproteins, and proteoglycan.

• Matrix metalloproteinases are excreted by a variety of connective tissue and pro-inflammatory cells including fibroblasts, osteoblasts, endothelial cells, macrophages, neutrophils, and lymphocytes.

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Transduction of MMPs

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Involvement of MMPs in physiological and pathologicalprocesses

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Activation of MMPs leads to........

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MMps in Pathological condition....

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MMPs and cancer

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Angiogenesis and MMPs

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Angiogenesis and MMPs Contd.....

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Wat happnes with in the blood vessels?? MMPs in blood vessels