Control theory and homeostasis
Control theory
That branch of mathematics and engineering which deals with thedesign, identification and analysis of systems with a view towardscontrolling them, i.e., to make them perform specific tasks or to behave in a desired way
Homeostasis
The ability and tendency of certain systems to maintain a relativelyconstant internal state in spite of changes in external conditions
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Human designed control systems
Human designed control systems
Cornelis Drebbel 1620
Human designed control systems
satellite attitude control
controller processactuator
sensor
inputfilter
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disturbance
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block diagram of a basic feedback control
Calcium homeostasis
TumbleCW
10µm
RunCCW
Increasing Chemical Gradient
Bacterial chemotaxis
biased random walk:
increase concentration -> decreased tumbling frequency
Tethering Analysis
Agonist changes rotational bias Kirby et al (JBC, 1999)
perfect adaptation of tumbling frequency
Zn
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intracellular nutrient homeostasis
a simplified model for Zinc homeostasis
Searching Pubmed
“homeostasis” 126408 hits
“control theory” 432
“homeostasis” AND “control theory” 27
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