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Noyes-Whiney
Noyes-Whiney
K D V SCsCt
Noyes-Whiney
Powders
1D1D2n
3
1
2
1
2
100100100100
123
4V
1. (1) 5,,,, 2 3 4 ,,
(CRH)(CRH)CRHCRHCRHAB = CRHA CRHBCRH1CRH23CRH
0.1~0.01g1090.01~0.001g1000.001g1000
Granules
105500um
12345
5131(2000m4250m82.0
10g200ml5
tablets1
tablets
2
(compressed tablets)(coated tablets)(multilayer tablets)(chewable tablets)(buccal tablets)(sublingual tablets)(solution tablets)(vaginal tablets)(effervescent tablets)(implant tablets)(hyperdemic tablets)
excipients
1234
diluentsfillers5mm50mg
1.starch 2. sucrose 3. dextrin 4. lactose 5. pregelatinized starch
6. (microcrystalline celluloseMCC) 7. 8. mannitol
1. 2. 30%70%
1 8%15%10%
2
1MC2HPC3HPMC 550cPas2%5%4CMC-Na 2%10%5EC EC
3 PVP
10%
PVPPVPK152500PVPK306000PVPK90300000
PVPK303%15%
4. 10%20%5PEGPEG4000PEG6000PEG6. 50%70%g/g
1
2300
3 4
1.
2CMS-Na 300
3.L-HPC 4.CCNa
5. PVPP
6.
7.
80
1
2
350%75%25%50%
25%50%50%75%
1
2
3
4
5PEG PEG4000PEG6000
6
3.13.23.33.43.5
25mg
3.1
()
1 2 3 50%60%
YK60
2025mm
1.
MCCHPMCPVPMCC
2.
1 2 3
1. 2. 3.
V
HZD
1
2
()
1
2
3 4 5
1 2 3
CJY300B
78X-2
40.3g7.5%0.3g5%202111/3
5
15min30min2h1h
6
701985
7
10mg5%
1.
Eudragit E100HPMCHPC
2.
151865%75%g/g1002030min40551518
3.
401015
4.
815
5.
2%
5.2 HPMCHPCECPEGPVP PEG
1
HPMCHPCCMC-NaHPMC
PVPPEG
,Eudragit
Eudragit E100Eudragit E
Eudragit LEudragit SEudragit L30D
Eudragit L100Eudragit S100
Eudragit RSEudragit RL
2
Eudragit RSEudragit RL
ECHPMCPEG
3pH
CAP
Eudragit LEudragit SEudragit L30DEudragit L100Eudragit S100
HPMCPCAP
HPMCAS CAPHPMCP
2 PEG300PEG400
3 PEG
6.1 6.2 6.3 6.4 6.5 6.6 6.7
6.1 1000 268g 136g 33.4g 266g(17%) q.s 15g 0.25g
6.1 1/312
6.2 100mgVB2(1000 5g 50% Q.S. 26g 0.7g 42g
6.3
6.4 E1000 E 5g 38.5g 95% 4g 10g 30g 15% 35g 41g 1g
6.5
6.5 1000 262g 40g 60g 7g 60g 20g
6.6 CO2
6.6 1000 20 325g 2050g 305g 520g
6.7 1000 30g 10g 25g 1g 23g 1g