123

41

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Noyes-Whiney

Noyes-Whiney

K D V SCsCt

Noyes-Whiney

Powders

1D1D2n

3

1

2

1

2

100100100100

123

4V

1. (1) 5,,,, 2 3 4 ,,

(CRH)(CRH)CRHCRHCRHAB = CRHA CRHBCRH1CRH23CRH

0.1~0.01g1090.01~0.001g1000.001g1000

Granules

105500um

12345

5131(2000m4250m82.0

10g200ml5

tablets1

tablets

2

(compressed tablets)(coated tablets)(multilayer tablets)(chewable tablets)(buccal tablets)(sublingual tablets)(solution tablets)(vaginal tablets)(effervescent tablets)(implant tablets)(hyperdemic tablets)

excipients

1234

diluentsfillers5mm50mg

1.starch 2. sucrose 3. dextrin 4. lactose 5. pregelatinized starch

6. (microcrystalline celluloseMCC) 7. 8. mannitol

1. 2. 30%70%

1 8%15%10%

2

1MC2HPC3HPMC 550cPas2%5%4CMC-Na 2%10%5EC EC

3 PVP

10%

PVPPVPK152500PVPK306000PVPK90300000

PVPK303%15%

4. 10%20%5PEGPEG4000PEG6000PEG6. 50%70%g/g

1

2300

3 4

1.

2CMS-Na 300

3.L-HPC 4.CCNa

5. PVPP

6.

7.

80

1

2

350%75%25%50%

25%50%50%75%

1

2

3

4

5PEG PEG4000PEG6000

6

3.13.23.33.43.5

25mg

3.1

()

1 2 3 50%60%

YK60

2025mm

1.

MCCHPMCPVPMCC

2.

1 2 3

1. 2. 3.

V

HZD

1

2

()

1

2

3 4 5

1 2 3

CJY300B

78X-2

40.3g7.5%0.3g5%202111/3

5

15min30min2h1h

6

701985

7

10mg5%

1.

Eudragit E100HPMCHPC

2.

151865%75%g/g1002030min40551518

3.

401015

4.

815

5.

2%

5.2 HPMCHPCECPEGPVP PEG

1

HPMCHPCCMC-NaHPMC

PVPPEG

,Eudragit

Eudragit E100Eudragit E

Eudragit LEudragit SEudragit L30D

Eudragit L100Eudragit S100

Eudragit RSEudragit RL

2

Eudragit RSEudragit RL

ECHPMCPEG

3pH

CAP

Eudragit LEudragit SEudragit L30DEudragit L100Eudragit S100

HPMCPCAP

HPMCAS CAPHPMCP

2 PEG300PEG400

3 PEG

6.1 6.2 6.3 6.4 6.5 6.6 6.7

6.1 1000 268g 136g 33.4g 266g(17%) q.s 15g 0.25g

6.1 1/312

6.2 100mgVB2(1000 5g 50% Q.S. 26g 0.7g 42g

6.3

6.4 E1000 E 5g 38.5g 95% 4g 10g 30g 15% 35g 41g 1g

6.5

6.5 1000 262g 40g 60g 7g 60g 20g

6.6 CO2

6.6 1000 20 325g 2050g 305g 520g

6.7 1000 30g 10g 25g 1g 23g 1g