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7/26/2019 Yersinia Pestis Practice Questions
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1. Name the three Yersinia species discussed in class.
2. A patient is suffering from acute gastroentitis and
mesenteric lymphadenitis after consuming
contaminated food and water. What kind of pathogen is he
infected with?3. Which Yersinia species are responsible for acute
gastroentitis and mesenteric lymphadenitis?
. !rotein made by Yersinia enterocolitica and Yersinia
pseudotuberculosis that allows in"asion of
epithelial cells by binding to #eta$1 integrins.
%. &ausati"e agent of black death
'. (ow is Yersinia pestis transmitted?
). (ow many pandemics of the #lack death ha"e there been?
*. What is a bubo?
+. What are the symptoms of bubonic plague?
1,. What symptom is reason why the plague is called the black
death?
11. What is the pneumonic plague?
12. (ow does the pneumonic plague occur?
13. (ow is the pneumonic plague spread from person to person?1.
-ram stain and structure of Yersinia pestis
1%. s Yersinia pestis motile?
1'. Yersinia pestis is a facultati"e anaerobe/ what does that
mean?
1). Name common animal reser"oirs for Yersinia pestis1*. 0ketch
the plague life cycle in animalshumans and show the role of fleas
in transmission.
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7/26/2019 Yersinia Pestis Practice Questions
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1+. Name all the Yersinia pestis "irulence factors.
2,. Name all the Yersinia pestis "irulence plasmids and the
products they encode for.
21. -enus and species of a flea that has been implicated in
transmission of the plague.
22. !arts of the fleas digesti"e tract that play a role in
plague transmission.
23. plain how Yersinia pestis can sur"i"e in the flea
midgut.
2. plain the role of biofilm formation by Yersinia pestis in
fleas. 4ake sure to eplain the
function of the biofilm/ how it is formed/ the role in
coloni5ation/ and why it6s important for
transmission.
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7/26/2019 Yersinia Pestis Practice Questions
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2%. plain how the flea en"ironment prepares the Yersinia pestis
bacteria for sur"i"al in a
mammalian host.
2'. What is the plasminogen acti"ator/ where on the bacteria is
it found/ when is it epressed/ what is
its target/ and why is it important?
2). What plasmid encodes for the type secretion system and Yops
proteins?
2*. What are Yops?
2+. What are the differences between the in "itro and in "i"o
en"ironments needed for the epression
and secretion of Yops?
3,. What is the function of Yops?
31. What are the classes of Yops and which Yops falls in which
class
32. What are the function of translocator Yops and list all of
the translocator Yops.
33. What is Yop and what is its mechanism of action
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7/26/2019 Yersinia Pestis Practice Questions
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3. What is Yop( and what is its mechanism of action
3%. What is Yop7 and what is its mechanism of action
3'. What is YpkA and what is its mechanism of action
3). What is Yop!8 and what is its mechanism of action
3*. What is Yop4 and what is its mechanism of action
