Welcome to TypeOneNation

2014

The Plan for a World without T1DPresented by: Carol Oxenreiter

Saturday, May 31, 2014

JDRF’s Vision for the Future

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FOR A W RLD WITHOUT TYPE 1 DIABETES

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LESS UNTIL NONE

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LESS UNTIL NONELESSLESS UNTIL NONE

BurdenInvasive

Complexity

Danger

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Delivery of Continuous Therapeutic Improvements

Side-EffectsComplicationsPatient Burden

Glycemic ControlSafety

Normal PhysiologyRestored

Therapies Cure

Easier, Safer, Less Worry, Better Life

The Plan: Work the Pipeline

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DELIVERY TOPATIENTS

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Artificial Pancreas

A series of systems that will automate insulin dosing and additional hormone delivery

Artificial Pancreas Artificial Pancreas

A series of systems that will automate insulin dosing and additional hormone delivery

Smart Insulin

Single dose of insulin that delivers insulin only where and

when needed

Artificial Pancreas

Single dose of insulin that delivers insulin only where and

when needed

Smart InsulinSmart InsulinEncapsulation

Implantable, beta cell replacement therapies restoring insulin

independence without the need for intensive immune suppression

Artificial Pancreas Smart Insulin EncapsulationEncapsulation

Implantable, beta cell replacement therapies restoring insulin

independence without the need for intensive immune suppression

Prevention

Slow or stop the progression of T1D before insulin dependence and

ultimately eliminate the possibility of ever developing T1D

Artificial Pancreas Smart Insulin Encapsulation

Prevention

Prevention

Slow or stop the progression of T1D before insulin dependence and

ultimately eliminate the possibility of ever developing T1D

Restoration

Beta cell growth protected from immune attack restoring insulin

independence without immune suppression

Artificial Pancreas Smart Insulin Encapsulation

Restoration Prevention

Restoration

Beta cell growth protected from immune attack restoring insulin

independence without immune suppression

Continuous Therapeutic Improvements N

EAR

TERM

ComplicationsDiabetic Eye Disease

Predictive Diagnostics

Artificial PancreasLow Glucose Suspend

Treat-to-Range

MID

TER

M

EncapsulationTreat-to-Target

Multihormone

EncapsulationImplantable Islets

Smart InsulinControl

PreventionSecondary Prevention

LON

G T

ERM

PreventionPrimary: Vaccine

ComplicationsComprehensivePrevention Therapy

RestorationNew Beta Cell GrowthProtected from Immune Attack

DELIVERY TOPATIENTS

Capabilities Across All Stages of the Pipeline

DELIVERY TOPATIENTS

$500 Million Research Portfolio

Broad and Diverse Portfolio

Artificial Pancreas Restoration Smart Insulin Encapsulation Prevention

DELIVERY TOPATIENTS

Capabilities Across All Stages of the Pipeline

Research and Development Expertise

DELIVERY TOPATIENTS

Capabilities Across All Stages of the Pipeline

Volunteer Engagement

Capabilities Across All Stages of the Pipeline

International Reach

DELIVERY TOPATIENTS

Capabilities Across All Stages of the Pipeline

Partnership

DELIVERY TOPATIENTS

Your Support

Capabilities

Plan

Vision

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