Supporting Information

Hollow Prussian Blue Nanospheres for

Photothermal/Chemo-Synergistic

TherapyLong Lua, Chuanbin Zhanga, Bingfang Zoua,b, Yongqiang Wanga∗

a Key Laboratory for Special Functional Materials of the Ministry of Education,

Henan University, Kaifeng 475004, P. R. China b School of Physics and Electronics, Henan University, Kaifeng 475004, P. R. China.∗Corresponding author. Email: wangyq@henu.edu.cn

Fig. S1. XRD patterns of Fe2O3, Fe2O3@PB and hollow PB nanospheres.

Fig. S2. IR spectra of Fe2O3, Fe2O3@PB and hollow PB nanospheres.

Fig. S3. The IR spectra of the Fe2O3@PB composite nanospheres synthesized in E/W

ratio 7:2 and 8:1. (Inset is the corresponding solutions.)

Fig. S4. The Fe2O3@PB composite nanospheres synthesized in solvent with E/W =

7:2 with different intervals (hours): (a) 1, (b) 2, (c) 4, the HPB nanospheres

synthesized by using Fe2O3 nanospheres with different sizes (nm): (d) 110, (e) 150, (f)

180.

Fig. S5 UV-Vis-NIR Absorbance curves of HPB (red) and PB (black) nanospheres

with the same mole.

Fig. S6. The N2 adsorption/desorption isotherms (The inset was pore size

distribution).

Fig. S7. Dynamic light scattering distribution curve of HPB nanospheres dispersed in

water (black) and blood serum (red).

Fig. S8. Body weight changes of nude mice treated with different treatments.