CURRICULUM VITAE (updated July 1, 2017)

NAME: Jack C. de la Torre

PLACE OF BIRTH: Paris, France

CITIZENSHIP: U.S.A.

OFFICE ADDRESS: University of Texas at AustinDepartment of Psychology108 E Dean Keeton Street Austin, Texas 78712

OFFICE TELEPHONE: 760-703-0585 (cell)

E-MAIL: jcdelatorre@comcast.net

EDUCATION AND DEGREES

1959 - 1963 B.S. Biology, American University, Washington, D.C.

1963 - 1966 University of Madrid School of Medicine,Madrid, Spain

1966 - 1969 Ph.D., Neuroanatomy, University of GenevaGeneva, Switzerland

1969 - 1969 Post-Doctoral, University Psychiatric Clinic,Geneva, Switzerland (Neuropathology Lab)

1969-1970 Post-Doctoral, University of Zurich, Zurich, Switzerland (Physiological Institute)

1977 - 1979 M.D., Autonomous University of Ciudad Juárez (Mexico) 1979 - 1981 Post-Graduate Medicine, University of Miami

Hospitals and Clinics, Miami, Florida

Foreign Languages: Spanish, French (fluent speaking, writing, reading)

APPOINTMENTS

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Sept. 1970 - Dec.1975 Assistant Professor of Neurological Surgery and Psychiatry University of Chicago School of Medicine

Sept.1972 – July, 1977 Staff Member (secondary appt.), Brain Research Institute, University of Chicago

Dec.1975 – May, 1977 Associate Professor of Neurological Surgery and Psychiatry Director, Head Trauma Lab, University of Chicago School of Medicine

June 1980 - July 1982 Associate Professor of Neurological Surgery and AnatomyDirector, Neurosurgery Research LaboratoriesUniversity of Miami School of Medicine

Sept.1982 - July 1994 Professor of Neurosurgery, Anatomy and Pharmacology University of Ottawa Faculty of Medicine

Sept.1982 – July 1986 Director, Experimental Surgery, University of Ottawa, Faculty of Medicine

Sept.1982-July 1994 Director, Neurosurgery Research Laboratories, University of Ottawa, Faculty of Medicine

July 1994 –Mar 1999 Professor of Neurosurgery and Neuroscience, University of New Mexico School of Medicine

Director, Neurosurgery Research Laboratories

Mar. 1999- July, 2001 Visiting Professor of NeuroscienceUniversity of California, San Diego

July 2001-June, 2003 Visiting Professor of PathologyUniversity California, San Diego

July 2003-Nov. 2007 Professor of Pathology (Adjunct)Case Western Reserve University, Cleveland

Sep 2007-May 2011 Senior Scientist, Banner Sun Health Research InstituteSun City, Arizona

June 2011-present Professor of Neuropsychology (Adjunct), University of Texas at Austin, Austin, Texas

Honors and Biographical Listings

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Summa Cum Laude, University of Geneva, 1969Ph.D. thesis: Increase of brain dopamine using L-dopa + dopa-decarboxylase inhibitor: Implications for Parkinson’s disease treatment. (work led to development of Madopar)

Conference Chairman: International Conference on the Biological Actions and Medical Applications of Dimethyl Sulfoxide, New York Academy of Sciences, September 1982.

Paddington Award, 1983. For work dealing with the biological activity of dimethyl sulfoxide in CNS damage.

Editor-in Chief and Founder, Filopodia (Ottawa Neuroscience Newsletter), 1984-88

Fellow - Stroke Council, American Heart Association, 1991

Conference Chairman: International Conference on Cerebrovascular Pathology in Alzheimer's Disease, New York Academy of Sciences, November 13-15, 1996

Senior Editor, Journal of Alzheimer’s Disease, 2011-

Editor, Frontiers in Bioscience, 3006-

Associate Editor, Neurological Research, 2002-

Editorial Board member: International Journal of Clinical and Experimental Medicine

Editorial Board member, Journal of Alzheimer’s Disease & Parkinsonism

Conference Chairman: Hemodynamics and Cerebral Perfusion in Alzheimer’s Disease, IBC 8th Annual Conference on Alzheimer’s Disease, Boston, MA, May 19-20, 1999

Marquis Who's Who - Frontiers in Science, 1984 - present

Canadian Who's Who - 1987- present

Marquis Who’s Who in Medicine and Healthcare, 2002-present

Marquis Who's Who in America, 2004-present

Marquis Who's Who in the World, 2005-present

CLINICAL ROTATIONS

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1978-1979 Senior Clerkship, University of Miami Clinics & Hospitals, Miami, FL

1979 -1980 Neuropathology Residency, Jackson Memorial Hospital, Miami, Florida, Florida State Medical License

1984-1996 Medical License, College of Physicians and Surgeons of Ontario, Canada (#55002) (inactive)

1980- 2002 U.S. DEA Registration # RD0204292 (inactive)

PATENTS

U.S. Patent No. 3,592,918 : Controlling Bacteria with a Fatty Tetraamine, 1971.

U.S. Patent No. 5,516,526: Medicinal for protection from neurologic damage. 1996.

U.S. Patent Prov. No.: 20090312273 : Neuroprotection from brain trauma and stroke

European Patent No. 11154666-2123: Compositions for Traumatic Brain Injury

TEACHING COURSES (Principal Instructor)

1970 - 77 Experimental Neurosurgery Elective, University of Chicago School of Medicine

1970 - 77 Clinical Anatomy Neurosurgery Residents’ Seminars, University of Chicago School of Medicine

1980 - 81 Brain Anatomy, University of Miami School of Medicine

1981-83 Neurosurgery Residents’ Journal Club, Northwestern Univ. Hospital

1981-83 Medical Students Neuroscience Research Techniques, Northwestern University School of Medicine

1983 - 94 Experimental Neurosurgery University of Ottawa, Faculty of Medicine

1983- 94 Brain Anatomy, (ANA 5455), University of Ottawa Faculty of Medicine

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1983 - 94 Neurosurgery Residents’ Journal Club (Ottawa General Hospital)

1995- 99 Experimental Pathology [Biomed 505], University of New Mexico 1993- 99 Medical Review Seminar, University of New Mexico

PARTICIPATING TEACHING COURSES (Co-Instructor)

1972 - 76 Biochemistry of the CNS, University of Chicago

1981-83 Resident’s Neurosurgical Research, Northwestern University

1983 - 94 Neuroscience Techniques (ANA 7400) Univ. of Ottawa Fac. Medicine

1983 - 90 Neuroanatomy & Neurophysiology, University ofOttawa, Faculty of Medicine

1984-90 Gross Anatomy (ANA 5450) University of Ottawa Faculty of Medicine

1983 - 94 Neuroscience Graduate Specialization Program,University of Ottawa Faculty of Medicine

1983 - 94 Resident's Neuroscience Seminars, Ottawa GeneralHospital (Neurosurgery Residents)

1990 - 94 Medical Pharmacology (PHA 2262), University of Ottawa, Faculty of Medicine

1990 - 94 General Pharmacology (PHA 5303), University of Ottawa, Faculty of Medicine

1994 - 99 Neuroscience Phase I Tutor, University of New Mexico School of Medicine

1995 – 99 Human Anatomy Lab, University of New Mexico School of Medicine

1999- 2001 Neuropathology: Brain Cutting, University of California, San Diego

INVITED EXTRAMURAL LECTURES IN THE UNITED STATES

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1970 - present: 318 invited lectures delivered nationally, excluding teaching assignments

INVITED FOREIGN LECTURES (Outside U.S.A.)

Hoffmann-La Roche Pharmaceuticals, Basel, SwitzerlandEnhancing central dopamine levels with L-dopa + Ro 4-4602, a dopa decarboxylase inhibitor: Relevance to the treatment of Parkinson’s disease. December 12, 1967

Universidad Autónoma de Mexico, Mexico City, Mexico, Facultad de Medicina,Instituto Nacional de Neurologia

Efectos de la inhibidora de la descarboxilasa en combinación con la L-dopa en la enfermedad de Parkinson. ("Role of decarboxylase inhibitors and L-dopa in Parkinson's Disease"). July 10, 1970

Collège de France, Unité de Pharmacotherapie, Paris, FranceLes taux centrales de la dopamine après la L-dopa. ("Central dopamine values after L-dopa"), October 4, 1972

University of British Columbia, B.C., Kinsmen's Laboratory, Vancouver, CanadaDimethyl sulfoxide in experimental head and spinal cord injuries. May 9, 1973.

Universidad de Madrid Facultad de Medicina, Madrid, Spain, Department ofPhysiology. La serotonina y convulsiones. ("Role of serotonin in seizures"). June 12, 1974.

Universidad de Zaragoza Facultad de Medicina, Zaragoza, Spain Falta de aumentos de la noradrenalina consecuente a trauma médular.("Lack of noradrenaline increase following spinal cord trauma"). June 17, 1974.

McGill University, Montreal, Canada"Ultrastructural detection of edema and its treatment following experimental brain infarction in monkeys." July 6, 1976.

Undersea Medical Symposium on Cerebral Embolism and Acute Stroke. Toronto, Canada

"DMSO in acute stroke: Basic considerations." April 25, 1977.

Wenner-Gren International Symposium Stockholm, SwedenNeurogenic Control of Cerebral Circulation: "Local cerebral blood flow following stimulation of locus coeruleus in monkeys and rats". June 13, 1977.

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CBF VIII International Symposium Copenhagen, Denmark"Effects of locus coeruleus stimulation on CBF in selected brain regions". June 20, 1977.

University of Lund, Lund, Sweden, Institute of Histology"The SPG histofluorescence method". June 21, 1977.

Hôpital de l'Université de Paris, Paris, France"Somatosensory evoked potentials in the prognosis of coma". June 24, 1977.

Hôpital Neurologique, Lyon, France International Symposium on the Clinical Applications of Evoked Potentials in Neurology. Can somatosensory evoked potentials diagnose brain death?" October 14, 1980.

Université de Lyon, Lyon, France“Examination par la fluorescence microscopique des monoamines centraux.” (Histofluorescent examination of central monoamines). October 15, 1980.

Universidad de los Andes, Instituto de Microscopía Electrónica, Merida, Venezuela(1) Catecolaminas en el sistema nervioso central.(2) Regeneración de axones catecolaminérgicos. May 20-21, 1981.

Nervous System Regeneration International Conference, Catania, Italy. Transected spinal cord axons regenerate into a collagen bioimplant.September 7, 1981

University of Ottawa, Ontario, Canada

Pathophysiology and treatment of ischemic stroke. November 14, 1981.

Hôpital de l'Université de Paris, Paris, France“Effects of prostanoids on brain ischemia.” December 19, 1982.

VI International Catecholamine Symposium, Göteborg, Sweden “Descending spinal catecholaminergic fibers regenerate.” June 11, 1983.

Weizmann Institute, Rehovot, Israel“Putting Humpty-Dumpty together again: Blueprint for repair of transected spinal cord.” June 12, 1984.

Hadassah-Hebrew University, Jerusalem, Israel“Prostaglandins cascade and stroke.” June 13, 1984.

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Merckle International Symposium, Neu-Ulm, W. GermanyThe TILT formula for CNS lesions. October 12, 1984.

First Spinal Cord Injury Research Symposium, Toronto, Canada “Physico-chemical repair and reconstructions of the spinal cord.” November, 1985.

Canadian Congress of Neurological Sciences, London, CanadaBridge implantation of transected spinal cord. June 24, 1986.

International Symposium on Peripheral Nerve Regeneration, Edmonton, Alberta, Canada

Five factors that may aid crushed rat sciatic nerve reconnection. July 20, 1986.

International Congress of Neuropathology, Stockholm, SwedenIs there a useful implant to bridge transected spinal cord? September 9, 1986.

Second Spinal Cord Injury Research Symposium, Toronto, CanadaCalcium-induced myelopathy and regeneration of spinal transmitters.Oct. 10, 1986.

University of Western Ontario, Dept. of Anatomy, London, Canada Calcium-induced spinal paralysis lowers central noradrenaline. February 20, 1987.

International Workshop on DMSO. Hannover, West Germany. Ultrastructural analysis of cerebral edema after experimental brain trauma using dimethyl sulfoxide. September 20, 1987.

Third International Symposium on Stroke. Florence, ItalyPharmacological manipulation of acute brain ischemia. September 30, 1987

Third Annual Spinal Cord Injury Research Symposium. Toronto, CanadaCollagen-omentum repair approach for transected spinal cord. October 2, 1987.

Society for Neuroscience, Toronto, CanadaTotal or partial brain ischemia: A new rat model. November 18, 1988.

Canadian Congress of Neurological Sciences, Ottawa, Canada Protective action of PGI2:DMSO in focal brain ischemia. June 15, 1989.

Canadian Congress of Neurological Sciences, Banff, CanadaExperimental chronic brain hypoperfusion kills hippocampal neurons selectively. June 29, 1990.

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Second International Conference on Alzheimer's Disease, Toronto, CanadaLoss of hippocampal neurons after chronic brain hypoperfusion in aged rats. July 18, 1990.

Neural Transplantation to Spinal Cord Injuries, Aarhus, DenmarkUse of neurotrophic-like agents on an omental graft-gel bridge after feline cord transection. August 30, 1990.

International Workshop on DMSO, Irdning, AustriaDimethyl sulfoxide in embolic stroke: Clinical and basic studies. October 19, 1990.

International Conference on Stroke, Geneva, SwitzerlandAged rat brain more vulnerable to metabolic and memory loss after chronic brain hypoperfusion than young brain. May 31, 1991.

Third IBRO (International Brain Research Organization) World Congress of Neuroscience, Montreal, Canada

Chronic brain ischemia in aged rats mimics human dementia. August 2, 1991.

International Conference for Studying CNS Disorders, Madrid, SpainNeuronal rescue of damaged hippocampal neurons after chronic brain ischemia. May 1, 1992.

Third International Conference on Alzheimer's Disease, Abano Terme, ItalyRestoration of CBF prevents ischemic-induced CA1 neuronal death in aged rats. July 15, 1992.

Second International Conference on Stroke, Geneva, SwitzerlandReversal of cerebrovascular insufficiency in aging rats. May 6, 1993.

6th International Symposium of Stroke and Neurotrauma, Martin, Slovak RepublicNeuronal rescue: a new twist to an old concept. August 16, 1993.

European Neuroscience Association, Madrid, SpainImprovement of CA1 ischemic cell damage and memory impairment after CBF restoration. September 19, 1993.

Spinal Cord Injury Research Symposium, Winnipeg, CanadaRepair and reconstruction of transected spinal cord. October 21, 1993.

Clinical Head Injury Conference, Gaziantep, Turkey

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Significance of brain ATP loss after severe, closed head injury. November 25, 1993.

First Ameflow Conference, Zug, Switzerland Measurement of experimental hippocampal blood flow. January 21, 1995

First International Congress of Omentum in CNS. Xuzhou, People's Republic of ChinaCBF increase from omental transposition as a possible treatment for Alzheimer's disease. May 9, 1995

Beijing Medical University, Beijing, People's Republic of ChinaBasic and clinical considerations in the study of dementia. May 10, 1995

Tokyo Psychiatric Institute, Tokyo, JapanMetabolic consequences of chronic cerebrovascular ischemia during aging. May 12, 1995

Universidade Federal de Sao Paulo, Escola Paulista de Medicina, Visiting Professor, Sao Paulo, Brazil,

1) Treatment of severe intracranial pressure, July 5, 1995, 2 A glycolytic intermediate-free radical scavenger use in head injury. July 6,

1995

Second Ameflow Conference on Cerebral Blood Flow, Zug, SwitzerlandCerebral blood flow in normal and ischemic aged rats. September 9, 1995

University of Groningen, Haren, The Netherlands, Laminar, chaotic and disordered brain blood flow: From normal to Alzheimer's disease. June 13, 1996.

International Behavioral Neuroscience Society, Cancún, Mexico, Combined use of a glycolytic intermediate and a free radical scavenger for

memory loss in aged rats. May 2, 1996.

European Neurochemical Society, Groningen, The Netherlands Pharmacologic reversal of memory loss. June 15, 1996

La Fé General Hospital, Valencia, SpainDeformación cérebromicrovascular en la Enfermedad de Alzheimer. June 24,

1996

Laboratoire de Neuropathologie, Hôpital de la Salpetrière, Paris, FranceCerebral energy deficits after chronic brain ischemia, neurodegeneration and

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memory dysfunction. January 30, 1997

Centre National de la Recherche Scientifique, Laboratoire de Recherches Cérébrovasculaires, Paris, France.

Un modèle vasculaire chez le rat de la maladie d’Alzheimer. January 31, 1997

International Joint Meeting of Physiology, Malaga, Spain.Pharmacologic reversal of memory dysfunction after chronic brain ischemia in

aged rats. February 5, 1997

Oxidative Stress, Biochemistry and Pathophysiology, Barcelona, SpainBrain cytochrome oxidase activity: A marker of neuronal dysfunction. June 7,

1997

6th World Congress of Biological Psychiatry, Nice, France.Abnormal microvasculature in Alzheimer brains induces metabolic and functional pathology. June 24, 1997

Canadian Paraplegic Association, St. John’s, Newfoundland.

Regenerative ability of transected spinal cord after surgical reconstruction.November 20, 1997

Fifth International Geneva Symposium in Alzheimer’s Disease. Geneva, Switzerland. Drug reversal of progressive memory loss induced by chronic brain

hypoperfusion in aging rats. April 16, 1998

Sixth International Conference on Alzheimer’s Disease. Amsterdam, The Netherlands, Regional cytochrome oxidase decline predicts neurodegeneration after chronic brain hypoperfusion. July 16, 1998

Janssen Research Foundation, Beerse, BelgiumRelevance of animal models in stroke and head injury to clinical application. October 2, 1998

Vascular Factors in Alzheimer’s Disease, Newcastle upon Tyne, UKCritically attained threshold of cerebral hypoperfusion (CATCH): Does it cause Alzheimer’s disease? May 29, 1999

Quest for Dementia Drugs, Tokyo Institute of Psychiatry, Tokyo, JapanCerebral hypoperfusion, capillary damage and the development of Alzheimer’s disease. October 2, 1999

MRI 2000, Hotel Grand Bretagne, Athens, GreeceCerebral hypoperfusion and the development of Alzheimer’s disease. Oct. 28, 2000

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Carleton University, Institute of Neuroscience, Ottawa, CanadaNitric oxide in an Alzheimer’s disease rat model, December 15, 2000

Emerging Therapeutic Options for Human Spinal Cord Injury, World Health Organization Reykjavik, Iceland,

Treatment approaches to acute and chronic spinal cord injury in humans. June 1, 2001

Canadian Congress of Neurological Sciences, Halifax, Nova Scotia, CanadaCombination treatment of fructose 1,6-diphosphate and dimethyl sulfoxide for traumatic brain injury in rats. June 15, 2001

Frontiers of Neurochemistry in the Treatment of Neurological Disorders. Florence, ItalyThe effect of cerebral hypoperfusion on endothelial nitric oxide in Alzheimer’s disease. October 12, 2001

37th Canadian Congress of Neurological Sciences, Vancouver, BC, Nitric oxide up-regulation after chronic brain ischemia precedes visuo-spatial impairment in rats. June 18-22, 2002

Third World Congress on Vascular Factors in Alzheimer’s Disease, Kyoto, JapanEvidence that Alzheimer’s disease is a vascular disorder. April 9, 2002

International Mini-Symposium, Tokyo Psychiatric Institute, Tokyo, JapanThe role of endothelial-derived nitric oxide in Alzheimer’s disease. April 11, 2002

6th International Conference on Alzheimer’s/Parkinson’s Disease. Role of vascular nitric oxide in Alzheimer’s disease. Seville, Spain, May 11, 2003

Universidad de Valencia, Centro de Investigación, Hospital Universitario La Fé. Hipoperfusion crónica cerebral en la rata aumenta el ‘uptake’ del oxido nitrico (Chronic brain hypoperfusion in rats upregulates hippocampal nitric oxide). Valencia, Spain, May 22, 2003

Ruhr University, International Graduate School for Neuroscience.Cerebrovascular basis of Alzheimer’s pathogenesis., Bochum, Germany, August 18, 2003

Universidad de Barcelona, Departamento de Farmacologia.Estrategias genómicas para aumentar el flujo sanguineo cerebral en la enfermedad de Alzheimer (Genomic approaches to increase cerebral perfusion in Alzheimer’s disease), August 25, 2003

Medizinische Fakultat der Humboldt Universitat, Johannes-Müller-Institut für Physiologie

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Cerebral endotheliopathy in Alzheimer’s disease. Berlin, Germany, August 21, 2003

First Congress of the International Society for Behavioral and Cognitive Disorders.Is coronary artery bypass surgery a risk factor for dementia? Goteborg, Sweden, August 29, 2003

First Annual Meeting on Brain Aging and Dementia.Vascular influences in the pathogenesis of Alzheimers’s disease. Perugia, Italy, September 19, 2003

Third Annual Congress on Vascular Dementia.Evidence supporting Alzheimer’s disease as a vascular disorder with neurodegenerative consequences. Prague, Czech Republic, October 24, 2003

Symposium on Brain Aging and Alzheimer’s Disease- Centro Internacional de Restauración Neurologica (CIREN).

A rat model of MCI upregulates hippocampal nitric oxide and precedes memory loss and A 1-40 accumulation after chronic brain hypoperfusion, Havana Cuba, February 24-27, 2004

International AD/PD Conference Vascular nitric oxide is a critical molecule in spatial memory function during chronic brain hypoperfusion. Findings from an experimental model of MCI.March 14, 2005, Sorrento, Italy.

University of British Columbia, Neuroscience Research Colloquia, Brain Research Centre,

Nitric oxide: Is it a key to the mystery of Alzheimer’s disease? Vancouver, B.C., October 28, 2005

V Simposio Internacional de la Enfermedad Cerebrovascular, ICTUS 2006Why is stroke a risk factor for Alzheimer's disease?  Havana, Cuba November 30, 2006

8th International Conference on AD/PD, 2007, Physiopathology linking stroke and heart disease to Alzheimer’s disease Salzburg, Austrria, March 18, 2007

International Conference on Current Hypotheses in Alzheimer’s Disease, The heart-brain vascular connection in Alzheimer’s disease: An old pathway to a

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new mind shift. Conference Town, Reñaca, Chile, November 24, 2007

Universidad de Concepción, Alzheimer’s Disease WorkshopIs vascular nitric oxide a key molecule to understanding Alzheimer’s disease?Concepción, Chile, November 26, 2007

9th International Conferece Alzheimer’s/Parkinson’s Disease (AD/PD), Detection of cardio-cerebral pathology using carotid artery ultrasound-echocardiography (CAUSE) for the prevention of cognitive impairment evolving to dementia. Prague, Czech Republic, March 11-15, 2009

Grants and Awards (Principal Investigator)NIH, 1970-1975: Blood-brain barrier penetration of L-dopa + dopa decarboxylase inhibitor. $225,650

NIH, Head Injury Center Grant 1970-1980: Neuropathologic evolution of cerebral edema in experimental head injury. Co-PI with Sean Mullan, $6,320,900

Purer Foundation, 1980-1982: Studies on supraspinal axon regeneration in rats. $100,000 (This grant and subsequent studies led to the creation of the Miami Project).

American Paralysis Association, 1983-1985: Neurotransmitter failure after calcium-induced myelopathy. $93,000

Canadian Paraplegic Society, 1983-1984: Role of astrocytes in spinal cord regeneration. $21,490

Canadian Heart Association 1983-1986: Effect of prostanoids in middle cerebral artery occlusion. $252,680.

Easter Seal Foundation, 1984-1986: Inhibition of TXA2 in cerebral ischemia. $63,320

Ottawa General Hospital Foundation,1984-1985: Biodegradable implants to bridge transected spinal cord in rats. $23,972Codman & Shurtleff, 1986-1988: Laser-aided reconstruction of peripheral nerve transection. $89,650

Heart and Stroke Foundation of Ontario, 1986-1989: Free radicals and energy metabolic deficits in brain ischemia. $213,720

March of Dimes Foundation, 1989-1991: Locus coeruleus implants and catecholaminergic reinnervation of ablated cortex. $18,200

International Spinal Research Trust, 1989-1991: Collagen-omentum reconstruction of transected feline spinal cord. $388,000

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National Research Council, 1991-1993: Brain pathology after aortic arch surgery. $24,560

Ontario Mental Health Foundation, 1990-1992: Nuclear magnetic resonance study of brain energy metabolism after global ischemia. $156,300

Ontario Heart & Stroke Foundation, 1993-1996: Cerebral metabolism and spatial memory loss after chronic brain ischemia in aged rats. $298,000

NIH (NIA), 1996, Conference: Cerebrovascular Pathology in Alzheimer’s Disease. $12,000

Hoechst, Marion Roussel, 1996-1997: Significance of cerebrovascular lesions in Alzheimer’s disease. $20,000

Astra Pharmaceutical, 1996-1997: Development and application of a rat model of dementia. $10,000

Collagen Corp., 1996-1998: Afibrillar collagen implant in rat cortical ablation. $62,000

Ramsauer Foundation, 1996-1999: Study of synaptogenesis after spinal cord transection and surgical reconstruction. $150,000

Carolwood Corporation, 1998-1999: Effects of endothelin and nitric oxide on spatial memory after chronic brain hypoperfusion. $31,440

North American Spine Society, 1998-1999: Antisense oligonucleotides in spinal cord trauma. $10,000. Co-PI with J. Ordonez

Alzheimer’s Association, 2000-2003: Neuronal energy metabolic disruption after chronic brain hypoperfusion. $179,300

Alzheimer’s Association, 2003-2007: The role of nitric oxide and endothelial function in rat chronic brain hypoperfusion. $239,371

PROFESSIONAL ORGANIZATIONS (Elected Membership*)Society for Neuroscience*

New York Academy of Sciences*

International Brain Research Organization (IBRO)*

Interamerican College of Physicians and Surgeons*

Royal Society of Medicine* (Great Britain)

Ottawa Neuroscience Society (President and Founder, l984-l987)15

College of Physicians and Surgeons of Ontario

Fellow, American Heart Association, Stroke Council*

International Psychogeriatric Association*

ABSTRACTS

1. de la Torre, J.C. and Mullan, S: Blood-brain barrier mechanisms for L-dopa. Neurology, 21:446, 1971.

2. de la Torre, J.C., Kajihara, K., Kawanaga, H.M., Rowed, D.W. and Mullan, S.: DMSO in the treatment of spinal cord injuries. Soc. Neurosci. Abstr., 1:78, 1972.

3. de la Torre, J.C., Johnson, C.M. and Mullan, S.: Treatment by dimethyl sulfoxide of experimental paraplegia subsequent to spinal cord trauma. Soc. Neurosci. Abstr., 1:329, 1973.

4. de la Torre, J.C., Walker, R.H. and Mullan, S.: Evidence for noradrenergic innervation of intracerebral blood vessels. Soc. Neurosci. Abstr., 1:676, 1975.

5. de la Torre, J.C. and Surgeon, J.W.: Brain and tissue monoamines histofluorescence visualization in 18 minutes. Fed. Proc., 35:242, 1976.

6. de la Torre, J.C.: Neurophysiology of movement disorders. Proceedings First Tarbox Parkinson’s Disease Symposium, Lubbock, Texas, p.2, 1976

7. de la Torre, J.C. and Trimble, J.L.: Clinical evaluations of the vegetative state using bilateral cortical evoked potentials. Soc. Neurosci. Abstr., 2:932, 1976

8. Boggan, J.E., de la Torre, J.C. and Mullan, S.: A rat model for the investigation of spinal cord injury. Soc. Neurosci. Abstr., 2:961, 1976.

9. Hill, P.K. and de la Torre, J.C.: Therapy after experimental MCA occlusion in monkeys: Ultrastructural features. Soc. Neurosci. Abstr., 2:137, 1976.

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10. Boggan, J.E. and de la Torre, J.C.: Spinal cord injury using a rat model. AMSA-UTMB Natl. Stud. Res. Forum, pp. 10-11, 1976.

11. de la Torre, J.C. and Hill, P.K.: Development and treatment of edema following experimental brain infarction in monkeys. Abstr. Dynamic Aspects of Cerebral Edema, Montreal, Canada, May 25-29, 1976. p. 46.

12. de la Torre, J.C.: Prognostic evaluation of clinical coma using somatosensory evoked responses. Neurology, 27:352, 1977.

13. Trauner, D.A. and de la Torre, J.C.: Effects of sodium octanoate on blood-brain barrier permeability. Soc. Neurosci. Abstr., 3:52, 1977.

14. de la Torre, J.C.: Further improvements in the SPG histofluorescence method and its application in concussive brain trauma. Fourth International Catecholamine Symposium Abstracts, Pacific Grove, California, p. 76, 1978.

15. de la Torre, J.C. and Hayashi, N.: A method for continuous and controlled drug delivery to the transected spinal cord. Soc. Neurosci. Abstr., 6:438, 1980.

16. Hayashi, N., de la Torre, J.C. and Green, B.A.: Changes in relative tissue oxygen consumption, tissue oxygen content and blood flow after spinal cord injury. Soc. Neurosci. Abstr., 6:709, 1980.

17. Hill, P.K., de la Torre, J.C. and Thompson, S.B.: A reliable E-M fixation procedure for the adult rat funiculi gracili. Soc. Neurosci. Abstr., 6:439, 1980.

18. de la Torre, J.C.: Standardization of the SPG histofluorescence method for monamine transmitters. Soc. Neurosci. Abstr., 5:333, 1979.

19. Hayashi, N., de la Torre, J.C., Greed, B.A., Mora, J. and Gonzalez-Carvajal, M.: Rat spinal cord laminar flows of gray and white matter using multiple micro-electrode hydrogen clearance. Neurology, 30:406, 1980.

20. de la Torre, J.C., Hill, P.K., Gonzalez-Carvajal, M. and Parker, J.C.: Microscope examination of regeneration spinal cord fibers after transection. Anat. Rec. 202:43A, 1982.

21. de la Torre, J.C., Hill, P.K. and Gonzalez-Carvajal, M.: Collagen bioimplant in rat spinal cord transection. Abstr., Proc. Regeneration of Nervous System, (A. Stella, ed.). Catania, Sicily, p. 59, 1981.

22. de la Torre, J.C.: Brain catecholamine regeneration into a non cellular bioimplant. Abstr. Proc. Internatl. Brain Research Org. Lausanne, Switzerland,

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April 1-5, 1982.

23. de la Torre, J.C.: Regeneration of catecholamine fibers into a collagen bioimplant after cortical ablation. Soc. Neurosci. Abstr., 7:260, 1981.

24. Hill, P.K., de la Torre, J.C., Thompson, S.M., Rosenfield-Wessels, S. and Beckett, M.L.: Ultrastructural features of dorsal column unmyelinated fibers after acute injury of the rat spinal cord and DMSO treatment. Soc. Neurosci. Abstr.,7:537, 1981.

25. de la Torre, J.C., Hill, P.K., Gonzalez-Carvajal, M. and Parker, J.C.: Regeneration of transected spinal cord axons into a collagen bioimplant. Neurology, 32:A213, 1982.

26. Hill, P.K., de la Torre, J.C., Bullock, D.L., Thompson, S.M. and Beckett, M.L.: Ultrastructural features of motor neurons and microvasculature in Rexed Area IX of the rat spinal cord after contusion and DMSO treatment. Anat. Rec.,202, 82A, 1982.

27. Hill, P.K., de la Torre, J.C., Bullock, D.L., Thompson, S.M. and Beckett, M.L.: Electron microscopic examination of rat spinal cord and dorsal column after contusion injury. Soc. Neurosci. Abstr., 8:998, 1982.

28. de la Torre, J.C., Gonzalez-Carvajal, M. and Hayashi, N.: Evoked potentials and spinal cord blood flows in transected rats. Soc. Neurosci. Abstr., 9:1200, 1983.

29. de la Torre, J.C. and Hill, P.K.: Morphology and regeneration spinal cord axons into a collagen matrix bridge. Soc. Neurosci. Abstr., 8:915, 1982.

30. Shipley, M.T., Hollaran, F.R. and de la Torre, J.C.: Exuberant locus coerulear input to rat olfactory bulb. Amer. Chem. Soc. Progr. Abstr., April 27 - May 1, 1983.

31. de la Torre, J.C.: The golden maze dilemma. Ann. NY Acad. Sci., 411:Xl, l983.

32. Shipley, M., Hollaran, F. and de la Torre, J.C.: Evidence for a strong orderly locus coeruleus projection to rat olfactory bulb. Soc. Neurosci. Abstr., 9:1150, 1984.

33. Hill, P.K., de la Torre, J.C., Bullock, L. and Thompson, S.M.: Ultrastructural response to fasciculi gracilis myelinated fibers, glia and capillaries to contusion and treatment. Anat. Rec., 205:82A, 1983.

34. de la Torre, J.C., Richard, M.T. and Ivan, L.: Spinal cord catecholamine changes after experimental calcium-induced myelopathy. Soc. Neurosci. Abstr., 10:31,

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1984.

35. de la Torre, J.C.: Putting Humpty-Dumpty together again: Experimental blueprint for severed spinal cord repair. Proc. Internatl. Symposium Processes of Recovery from Neural Trauma. Rehovot, Israel, p. 3, 1984.

36. de la Torre, J.C., Richard, M. and Ivan, L.P.: Sciatic nerve, muscle or collagen matrix for transected spinal cord repair. Soc. Neurosci. Abstr., 11:1254, 1985.

37. de la Torre, J.C., Richard, M. and Ivan, L.P.: Status report on DMSO in brain and spinal cord injuries. Proceedings of the International Scientific Workshop on The Use of DMSO in Medicine, p. 19, Neu-Ulm, Germany, October 12-14, 1985.

38. Morassutti, D., Richard, M.T. and de la Torre, J.C.: A new model for the study of calcium-induced myelopathy in rats. Neurology, 36 (Suppl. 1): 256, 1986.

39. Goyal, R., Karaca, M., Lach, B., Benoit, B., Russell, N.A. and de la Torre, J.C.: Nerve reconnection using collagen matrix. Can. J. Neurosci., 13:176, 1986.

40. Morassutti, D.J., de la Torre, J.C., Merali, Z. and Richard, M.: A study of calcium-

induced myelopathy in rats. Can. J. Neurol. Sci., 13:177, 1986.

41. de la Torre, J.C., Karaca, M. and Merali, Z.: Peripheral nerve damage, repair and reconstruction: Laser or razor? Annals Neurol., 20:144, 1986.

42. de la Torre, J.C. and Ivan, L.P.: Is there a useful implant to bridge transected spinal cord? Progr. Abstr. X Int. Congress Neuropath., Stockholm, 1986.

43. de la Torre, J.C.: Physico-chemical repair and reconstruction of transected spinal cord. First Annual Spinal Cord Injury Res. Symp. Progr. Abstr., CanadianParaplegic Assoc., Toronto, Nov. 22, 1985.

44. de la Torre, J.C.: Bridge implantation in transected rat spinal cord. Can J. Neurol. Sci., 13:176, 1986.

45. de la Torre, J.C., Karaca, M. and Merali, Z.: Laser repair and reconstruction of crushed peripheral nerve. Soc. Neurosci. Abstr., 12:11, 1986.

46. de la Torre, J.C., Morassutti, D., Fortin, T. and Richard, M.T.: Calcium-induced myelopathy and regeneration of spinal transmitters. Second Annual Spinal Cord Injury Res. Symp. Progr. Abstr., Canadian Paraplegic Assoc., Toronto, Oct.10, 1986.

47. de la Torre, J.C., Morassutti, D., Merali, Z., Fortin, T. and Richard, M.: Calcium-

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induced spinal paralysis reduces norepinephrine. Anat. Rec., 218:155A, 1987.

48. de la Torre, J.C. and Goldsmith, H.S.: Collagen-omentum repair after experimental spinal cord transection. Ann. Neurol., 22:14l-142, 1987.

49. de la Torre, J.C., Fortin, T.R. and Richard, M.T.: Pharmacological cytoprotection of cortical catecholamines after experimental embolic stroke. Soc. Neurosci. Abstr., 13:1629, 1987.

50. de la Torre, J.C.: Hyperbaric oxygen or DMSO for cerebral ischemia. Neurosurgery, 20:668, 1987.

51. Harman, K. and de la Torre, J.C.: Possible sources of influence on early reconnection of transected rat sciatic nerve. Soc. Neurosci. Abstr., 13:1210, 1987.

52. de la Torre, J.C., Goldsmith, H., Fortin, T. and Richard, M.: Collagen-omentum repair approach (CORA) for transected spinal cord. Third Annual Spinal Cord Injury. Res. Symp. Progr. Abstr., Canadian Paraplegic Assoc., p. 3, 1987.

53. de la Torre, J.C., Goldsmith, H. Fortin, T., Steward, E. and Richard, M.: Transected spinal cord axons cross a 6 mm gap. Neurology, (Suppl. 1) 38:232, 1988.

54. de la Torre, J.C. Fortin, T. and Thakar, J.: Total or partial brain ischemia: A new rat stroke model. Soc. Neurosci. Abstr., 14:1211, 1988.

55. de la Torre, J.C., Fortin, T., Thakar, J. and Richard, M.: A rat model for studying post-ischemic reperfusion. Stroke, 20:145, 1989.

56. de la Torre, J.C., Saunders, J.K., Fortin, T., MacTavish, J. and J., Butler, K.: Rat brain ATP recovers after prolonged CBF arrest. Soc. Neurosci. Abstr., 15:29, 1989.

58. de la Torre, J.C., Fortin, T., Saunders, J., MacTavish, J. and Richard, M.T.: Phosphate energy metabolites after CBF arrest. Ann. Neurol., 26:132, 1989.

59. de la Torre, J.C., Fortin, T., Saunders, J., and MacTavish, J.: Loss and

restoration of ATP after rat brain ischemia using NMR spectroscopy. Can. J. Neurol. Sci., 16:256, 1989.

60. de la Torre, J.C. and Richard, M.T.: Protective action of combined prostacyclin: dimethyl sulfoxide in focal brain ischemia. Can. J. Neurol. Sci., 16:236, 1989.

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61. Harman, K. and de la Torre, J.C.: The influence of angiogenesis on reconnection prior to axonal elongation. Soc. Neurosci. Abstr., 14:498, 1989.

62. Harman, K. and de la Torre, J.C.: An improved model to study rat sciatic nerve regeneration. Soc. Neurosci. Abstr., 15:884, 1989.

63. de la Torre, J.C.: Review of clinical and experimental pharmacologic therapy in neurotrauma and stroke. Fourth Internat. Symposium on the Diagnosis and Treatment of Stroke. Florence, Italy, April 19-21, 1989.

64. de la Torre, J.C., Goldsmith, H.S. and Richard, M.T.: Can supraspinal axons regenerate after cord transection? Proc. Amer. Assoc. Neurol. Surg., Washington, D.C., Sept. 24, 1989.

65. de la Torre, J.C., Fortin, T., Saunders, J. and Richard, M.T.: No-reflow phenomenon is absent in rats. Stroke, 21:161, 1990.

65. de la Torre, J.C., Fortin, T., Saunders, J., Butler, K. and Richard, M.: Experimental chronic brain hypoperfusion kills hippocampal neurons. Can. J. Neurol. Sci., 17:238, 1990.

66. de la Torre, J.C., Fortin, T., Saunders, J., Butler, K. and Richard, M.: Loss of hippocampal neurons after chronic brain hypoperfusion in aged rats. Neurobiol. of Aging, 11:328-329, 1990.

67. Harman, K., Katnick, J. and de la Torre, J.C.: A "black-box" approach for testing putative neurotrophic factors in regenerating sciatic nerve. Can. J. Neurol. Sci., 17:218, 1990.

68. de la Torre, J.C., Saunders, J., Fortin, T. and Richard, M.T.: Neuronal vulnerability in aged rats after chronic brain hypoperfusion. Ann. Neurol., 28:260, 1990.

69. de la Torre, J.C. and Goldsmith, H.S.: Supraspinal fibers may reconnect transected spinal cord after surgical reconstruction. Neurology, 41(2):15, 1991.

70. de la Torre, J.C., Park, G., Saunders, J., Fortin, T., de Socarraz, H., Butler, K., Pappas, B. and Richard, M.: Aged rat brain more vulnerable to metabolic and memory loss in aged rat brain after CVI than young rat brain. Proceedings Intern. Conf. on Stroke, Geneva, Switzerland, p.41, 1991.

71. de la Torre, J.C., Fortin, T., Park, G., de Socarraz, H., Saunders, J. and Pappas,

B.: Chronic brain ischemia in aged rats mimics human dementia. Abstr., IBRO

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World Congress of Neuroscience, Montreal, p.325, 1991.

72. de la Torre, J.C., Park, G., Fortin, T., de Socarraz, H., Saunders, J., Pappas, B. and Richard, M.: Young but not aged rats recover from chronic brain ischemia. Stroke, 22:137, 1991.

73. de la Torre, J.C., Park, G., Fortin, T., Katnick, J., Butler, K., Kozlowski, P., Saunders, J., Pappas, B. and Richard, M.: Alzheimer-like deficits after chronic brain ischemia in rats. Ann. Neurol., 30:286, 1991.

74. Harman, K., Katnick, J., Lim, R. and de la Torre, J.C.: More regenerated axons in the distal stump of transected sciatic nerve treated with glial maturation factor. Abstr. Soc. Neurosci., 17:1499, 1991.

75. de la Torre, J.C., Park, G., Fortin, T., Katnick, J., Saunders, J., Butler, K., Kozlowski, P., Pappas, B. and Richard, M.: Alzheimer deficits develop in aged rats after chronic cerebrovascular insufficiency. Abstr. Soc. Neurosci., 17:1066, 1991.

76. de la Torre, J.C., Fortin, T., Park, G.A.S., Butler, K., Kozlowski, P., Saunders, J.K., Pappas, B. and Richard, M.: Neuronal rescue of damaged hippocampal neurons after chronic brain ischemia. Behav. Pharmacol. 3 (Suppl. 1), 83-84, 1992.

77. de la Torre, J.C., Fortin T., Park, G.A.S., Butler, K., Kozlowski, P., Saunders, J., Pappas, B. and Richard, M.: Reperfusion after chronic brain ischemia reverses neuronal damage in aged rats. FASEB J., 6:A1917, 1992.

78. Goldsmith, H.S. and de la Torre, J.C.: Supraspinal fibers can reconnect transected spinal cord after surgical reconstruction. Rest. Neurol. Neurosci., 4:218, 1992.

79. de la Torre, J.C., Fortin, T., Park, G., Butler, K., Kozlowski, P., Saunders, J., Pappas, B. and Richard, M.: Ischemic damaged CA1 neurons can be "rescued" in aged rats. Neurobiol. Aging 13 (Suppl. 1) 548, 1992.

80. Park, G.A., Fortin, T., Pappas, B., Saunders, J. and de la Torre, J.C.: Neuronal rescue during chronic brain ischemia. Abstr. Soc. Neurosci., 18:1582, 1992.

81. de la Torre, J.C.: Does brain microvessel pathology provoke Alzheimer's disease? Abstr. Soc. Neurosci., 18:564, 1992.

82. de la Torre, J.C., Fortin, T., Saunders, J., Butler, K. and Richard, M.: The no-reflow phenomenon is a post-mortem artifact. Stroke, 23:1388, 1992.

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83. de la Torre, J.C., Fortin, T., Park, G., Butler, K., Kozlowski, P., Saunders, J., Pappas, B. and Richard, M.: Ischemic CA1 neuronal rescue in aged rats. Third International Conference on Alzheimer's Disease. Abano Terme, Italy, July 15, 1992.

84. de la Torre, J.C. and Richard, M.: Reversal of CVI in aged rats. J. Neurosurg. 78:321, 1993.

85. de la Torre, J.C. and Fortin, T.: Characterization of a chronic rat model of Alzheimer's disease. Ann. Neurol. 34:257, 1993.

86. de la Torre, J.C., Fortin, T., Park, G. and Pappas, B.: Spatial memory loss without morphological damage to CA1 neurons. Soc. Neurosci. Abstr. 19:1045, 1993.

87. de la Torre, J.C.: Possible pathogenesis of Alzheimer's disease. New Research Progr. Abstr., Amer. Psychiatric Assoc., San Francisco, CA, May 27, 1993, p. 255.

88. de la Torre, J.C., Fortin, T., Park, G. and Pappas, B.: Reversal of cerebrovascular insufficiency in aging rats. Second International Conference on Stroke. Prog. Abstr., Geneva, Switzerland, 1993.

89. de la Torre, J.C., Fortin, T., Pappas, B.A., Park, G., Richard, M.: Memory loss after chronic brain ischemia in aging rats. J. Neurosurg. 80:368, 1994.

90. de la Torre, J.C.: Alzheimer's disease caused by impaired delivery of energy substrates to the brain? Proc. Fourth Internat. Conf. Alzheimer's Disease, Minneapolis, p.38, 1994.

91. Filgueiras, C.L., Winsborrow, B., Ye, J., Kozlowski, P., de la Torre, J.C., Saunders, J.K., Deslauriers, R., Salerno, T: Brain histopathological evaluation after aortic arch surgery. The Brain and Cardiac Surgery, 3rd Internat. Conference, Key West, FL Sept. 22-26, 1994.

92. Pappas, B.A., de la Torre, J.C., Keyes, M., Davidson, C., Fortin, T: Chronic ischemia causes progressive dementia in middle aged rats. Soc. Neurosci. Abstr. 20:178, 1994.

93. de la Torre, J.C: Combined dimethyl sulfoxide-fructose 1,6-diphosphate in experimental head injury. Soc. Neurosci. Abstr. 20:194, 1994.

94. de la Torre, J.C.: An integrative hypothesis on the pathogenesis of Alzheimer's disease. Third Internat. Springfield Symp. on Alzheimer's Therapy. May 11-15,

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1994

95. Pappas, B.A., de la Torre, J.C., Davidson, C., Keyes, M., Fortin, T: Chronic brain Ischemia causes memory and neuronal dysfunction. Proc. Fourth Int Behav. Neurosci. Soc. Santiago de Compostela, May 18, 1995.

96. de la Torre J.C., Pappas, B.A., Davidson, C., Keyes, M., Fortin T: Progressive neurodegeneration in rats after chronic 2-VO or 3-VO. Soc. Neurosci Abstr

21:482, 1995

97. Bennett, S.A.L., Lakins, J., Fortin, T., Tenniswood, M.P., de la Torre, J.C., Pappas, B.A.: Pro-inflammatory response molecules are differentially associated with apoptosis and cerebral inflammation in an experimental model of Alzheimer's

disease. Soc. Neurosci. Abstr. 22:1209, 1996

98. de la Torre, J.C., Cada, A., Nelson, N., Sutherland, R., Gonzalez-Lima, F.: Reduced cytochrome oxidase activity in CA1 neurons and posterior parietal

cortex after chronic brain ischemia. Soc. Neurosci. Abstr. 22:463, 1996

99. Pappas, B.A., Davidson, C.M., Fortin, T., de la Torre, J.C.: Morris water maze impairments in ischemic rats: is retinal damage the cause? Soc. Neurosci. Abstr. 22:2145, 1996

100. de la Torre, J.C., Pappas, B.A., Fortin, T.: Treatment with a combined glycolytic intermediate and a free radical scavenger reverses ischemia-induced memory

loss. Abstr. Internat. Behav. Neurosci. Soc., p 29, 1996

101. de la Torre, J.C., Nelson, N., Sutherland, R.J.: Pharmacologic reversal of memory deficits in aging rats. J. Neurochem. (Suppl. 2) S11, 1996

102. Cada, A., de la Torre, J.C., Gonzalez-Lima, F: Regional alterations in activity patterns of cytochrome oxidase after chronic cerebrovascular insufficiency in aged rats. Soc. Neurosci. Abstr. 23:1376, 1997

103. Luiten, P.G.M., de Jong, G., Keijser, J., de la Torre, J.C.: Chronic cerebral hypoperfusion causes microvascular degeneration in hippocampal CA1 but not dentate gyrus and induces spatial memory impairment. Soc. Neurosci. Abstr. 23:1593, 1997

104. Pejic, L., Isaac, L., de la Torre, J.C.: Apoptotic cells in the CA1subfield of the hippocampus after common carotid artery ligation in the rat. Soc. Neurosci. Abstr. 23:2176, 1997.

105. Abdollahian, N.P., Cada, A., Kinney, M.,Gonzalez-Lima, F., de la Torre, J.C.:

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Chronic brain ischemia produces progressive memory impairment in rats due to dysfunction of the oxidative energy metabolism. Soc. Neurosci. Abstr. 23:832, 1997.

106. de la Torre, J.C., Sutherland, R.J., Nelson, N., Pappas, B.A.: Reversal of chronic memory dysfunction with a combination free radical scavenger-glycolytic intermediate. Soc. Neurosci. Abstr. 23:1367, 1997

107. de la Torre, J.C.: Abnormal microvasculature in Alzheimer brains induces metabolic and functional pathology. Biol. Psychiat. 42:(1), 91S, 1997

108. de la Torre, J.C.: Cerebrovascular pathology of Alzheimer’s disease. IBRO News, 25:8, 1997

109. de la Torre, JC, Hachinski, V: The long search. Ann. NY Acad. Sci. 826:xiii, 1997

110. de la Torre, J.C.: CPAD conference summary. Stroke 28:B4-B5, 1997

111. de la Torre, J.C.: Regional cytochrome oxidase decline predicts neuronal atrophy after chronic brain hypoperfusion. Neurobiol Aging 19:S263, 1998

112. de la Torre, J.C.: An unified hypothesis for Alzheimer’s disease. Soc. Neurosci. Abstr. 24:1220, 1998

113. de la Torre, JC: Critical threshold cerebral hypoperfusion: Does it cause Alzheimer’s disease? Alzheimer’s Reports 2 (suppl 1):S52, 1999

114. Henderson B, de la Torre JC. Reversal of chronic ischemia in the adult rat: Common carotid anastomosis and improvement in memory dysfunction. Soc Neurosci 25:55, 1999

115. De Jong, GI, Farkas, E, de la Torre, JC, Luiten, PGM: Capillary changes in aging,

experimental cerebral hypoperfusion and Alzheimer’s disease. Alzheimer’s Reports 2(suppl 1):S39, 1999

116. Karaca M, Kilic E, Yazici B, Demir S, de la Torre JC: Effects of a combined free radical scavenger-glycolytic intermediate on an elderly group with ischemic stroke. Stroke 31:325, 2000

117. Park JS, de la Torre JC. Combination treatment of fructose 1,6-diphosphate and dimethyl sulfoxide for traumatic brain injury in rats. Can. J. Neurol. Sci. 28 (Suppl 2), S25, 2001

118. Karaca M, Kilic E, Yazici B, Demir S, de la Torre JC: Treatment of ischemic stroke in elderly patients using a free radical scavenger-glycolytic intermediate

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compound. Soc. Neurosci Abstr. 26:784, 2000

120. Park JS, de la Torre JC. Treatment of traumatic brain injury in rats using fructose 1,6-diphosphate-dimethyl sulfoxide cocktail. Soc. Neurosci Abstr. 27: 2001

121. de la Torre JC, Pappas BA, Emmerling M, Stefano GB, Prevot V: Nitric oxide up-regulation after chronic brain ischemia precedes visuo-spatial impairment in rats. J Can Neurol Sci 29 (Suppl 1):s16, 2002

122. de la Torre JC. Alzheimer disease as a vascular disorder: Nosological evidence—Response. Stroke, 33(9): 2147 – 2148, 2002.

123. de la Torre JC: Alzheimer’s alert. Science News 161:3, 2002

124. de la Torre JC, Pappas BA, Emmerling M, Stefano GB, Prevot V: Nitric oxide up- regulation after chronic brain ischemia precedes visuo-spatial impairment in rats. J Can Neurol Sci 29 (Suppl 1):s16, 2002

125. de la Torre JC: Alzheimer’s disease is a vasocognopathy. Program # 40.5, Abstract, Soc Neuroscience, 2003

126. Aliev G, Seyidova D, Smith MA, Perry G, de la Torre JC. Vascular hypoperfusion and mitochondrial abnormalities induce oxidative stress that appeared to be a key factor for the development of Alzheimer disease. Cardiovasc. Pathology 13:S26-S27, 2004

127. de la Torre JC, Emmerling MR, Stefano GB, Aliev G. A rat model of MCI upregulates hippocampal nitric oxide and precedes memory loss and Abeta 1-40 accumulation after chronic brain hypoperfusion. Restorative Neurol Neurosci. 21(5,6):264, 2004

128. Aliev G, Siedlak SL, Smith MA, de la Torre JC, Perry G. Vascular and metabolic failure in Alzheimer disease. Neurobiol Aging 25 (No. S2):S61, 2004

129 de la Torre JC, Aliev G. Vascular nitric oxide: a key molecule in the pathogenesis of Alzheimer’s disease? Neurobiol Aging 25(No. S2):S50, 2004

130. Goldsmith HS, de la Torre JC. Vascular dynamics in Alzheimer and vascular dementia. Neurol Res. 26(5):453, 2004

131. Seyidova D, Siedlak S, Obrenovich ME, Head C, Cotman CW, Liu JN, Ames BN, Smith MA, Perry G, de la Torre JC, Aliev G.The mitochondria DNA deletion, increased in aged dog brain, can be diminished following administration of

supplemental antioxidants and mitochondrial cofactors. Program # 1017.9, Abstract Viewer, Soc Neuroscience, 2004, Online.

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132. Aliev G, Perry G, Chen S.G, Smith MA, de la Torre JC. Vasoactive substances, hypoperfusion, mitochondria failure and oxidative stress in aging and Alzheimer’s disease. Proceedings of the Fourth International Congress on Vascular Dementia Porto, Portugal October 20-23, 2005.

133. Aliev G, Perry G, Liu J, Smith MA, Chen SG, Ames BN, de la Torre JC. The primary pathogenetic role of vascular contains vasoactive substances, hypoperfusion, mitochondria failure and oxidative stress in aging and Alzheimer disease. In: Alzheimer’s Association International Conference on Prevention of Dementia (June 18-21, 2005, Washington, D.C.). In: Alzheimer’s & Dementia, 2005:1(1); S1, S31: P-074.

134. de la Torre J.C. and Aliev G. Vascular nitric oxide is a critical molecule in spatial memory function during chronic brain hypoperfusion. Findings from an experimental model of MCI. In: International AD conference in Sorrento (March, 2005 Italy). Plenary Invited Lecture.

135. Aliev G., Perry G., Smith M.A., Chen S.G., de la Torre J.C. and Burnstock G. The role of nitric oxide and ET-1 in the pathobiology of cardiovascular diseases and neurodegeneration. Proceedings from the Ninth International Conference on Endothelin, Park City, Utah, USA, September 11-14, 2005, PO 021, p39

136. de la Torre JC. Physiopathology linking stroke and heart disease to Alzheimer’s disease. Neurodegenerative Dis. 4 (Suppl 1): 273, 2007

137. Aliev G, Puchowicz M, Xu K, Shenk J, Smith MA, de la Torre JC, Perry G, LaManna JC. APOE deficiency induces age-dependent brain hypoperfusion, neurono-glial and microvascular damage in mice. Neurodeg Dis 4(Supl 1):182, 2007

138. Aliev G, Perry G, Puchowicz M, Xu K Shenk J, Smith MA, de la Torre JC. The primary role of vascular hypoperfusion and oxidative stress in Alzheimer’s disease. Atherosclerosis 8(1):105, 2007

139. de la Torre JC: The dark side of neuronal energy crisis: Can it explain Alzheimer’s disease? Brain Energy Metabolism and Blood Flow, Gordon Research Conference Proceedings, Aug 25, 2010, Andover, NH.

140. de la Torre JC. Vascular nitric oxide as part of a molecular mosaic in the development of Alzheimer’s disease. The XXVth International Symposium on Cerebral Blood Flow, Metabolism and Function, J Cerebral Blood Flow Metab. In press, 2011

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PUBLICATIONS

1. de la Torre, J.C.: The effects of LSD-25 on the septal region of the rat brain: Nature, 219:954-956, 1968.

2. de la Torre, J.C.: Monoamines cérébrales avec reference particulière à l'hypothalmus: La dopa+inhibiteur de la decarboxylase (Ro 4-4602) et barrière hémato-encéphalique. Méd. Hyg. (Geneva) 1477:1-16, 1968.

3. Constandinidis, J., de la Torre, J.C., Tissot, R. and Geissbuhler, F.: La barrière capillaire pour la dopa dans le cerveau et les différents organes. Psychopharmacologia, 15:75-87, 1969.

4. Constandinidis, J., de la Torre, J.C. and Tissot, R.: Essai de localisation des monoamines cérébrales dans l'hypothalamus humain. Path. Biol., 17:361-363, 1969.

5. Constandinidis, J., de la Torre, J.C. and Huggel, H.: Les monoamines cérébrales lors de l'hibernation chez la chauve souris. Rev. Suisse Zool., 77:345-352, 1969.

6. de la Torre, J.C.: Penetration of monoamine precursors through the blood-bain barrier using dimethyl sulfoxide. Ann. Int. Med., 72:806-807, 1970.

7. de la Torre, J.C., Kawanaga, H. and Mullan, S.: Seizure susceptibility after changes in brain serotonin levels. Arch. Int. Pharmacodyn, 188:298-304, 1970.

8. de la Torre, J.C. and Mullan, S.: A possible role for 5-hydroxytryptamine in drug-induced seizures. J. Pharm. Pharmacol., 22:858-859, 1970.

9. de la Torre, J.C.: Relative penetration of L-dopa and 5-HTP through the brain barrier using dimethyl sulfoxide. Experientia, 26:1117-1119, 1970.

10. de la Torre, J.C.: The blood-brain barrier for L-dopa in the hypothalamus. J. Neurol. Sci., 12:77-93, 1971.

11. de la Torre, J.C.: Crossing the blood-brain barrier, Univ. Chicago Rep., 21:1-3, 1971.

12. de la Torre, J.C. and Boggan, W.O.: Inflated brain dopamine values following L-dopa administration. Brain Inf. Serv. Conf. Rep., 19:9-10, 1971.

13. de la Torre, J.C. and Mullan, S.: Experimental evaluation of L-dopa penetration in brain. Trans. Am. Neurol. Assoc., 96:227-229, 1972.

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14. de la Torre, J.C.: Catecholamines in the human diencephalon: A histochemical fluorescence study. Acta Neuropathol., 21:165-168, 1972.

15. de la Torre, J.C., Rowed, D.W., Kawanaga, H.M. Mullan, S.: Modification of experimental head injury using dimethyl sulfoxide. Ann. Int. Med., 76:878-879, 1972.

16. Lim, R., de la Torre, J.C. Mullan, S.: Protein and enzyme alterations in experimental brain injury. Arch. Neurol., 27:314-321, 1972.

17. de la Torre, J.C., Boggan, W, Lovell, R.A.: A common error in brain dopamine assays. J. Pharm. Pharmacol., 24:481-485, 1972.

18. de la Torre, J.C., Kajihara, K., Rowed, D.W., Kawanaga, H.M. and Mullan, J.F.: Modification of experimental head and spinal cord injury. Trans. Amer. Neurol. Assoc., 97:230-233, 1972.

19. Kajihara, J., Kawanga, H.M., de la Torre, J.C. and Mullan, S.: Dimethyl sulfoxide in the treatment of experimental acute spinal cord injury. Surg. Neurol., 1:16-22, 1973.

20. de la Torre, J.C.: Localization of dopamine in brain following administration of levodopa and a decarboxylase inhibitor. In: Treatment of Parkinsonism - The Role of Dopa Decarboxylase Inhibitors. M. Yahr (ed.). Raven Press, New York, pp. 59-77, 1973.

21. de la Torre, J.C., Rowed, D.W. Kawanaga, H.M. and Mullan, S.: Dimethyl sulfoxide in the treatment of experimental brain compression. J. Neurosurgery, 38:345-354, 1973.

22. Rowed, D.W. and de la Torre, J.C.: Dimethyl sulfoxide in experimental hypoxic respiratory depression. Arch. Int. Pharmacodyn Ther., 204:105-109, 1973.

23. de la Torre, J.C.: On modifying behavior. Univ. Chicago Rep., 21:11-12, 1973.

24. Mullan, S., de la Torre, J.C., Kajihara, K. and Kawanaga, H.M.: Use of dimethyl sulfoxide in experimental head and spinal cord injuries. J. Neurol. Neurosurg. Psychiat., 36:153-154, 1973.

25. de la Torre, J.C., Johnson, C.M., Harris, L., Kajihara, K. and Mullan, S.: Monoamine changes in experimental head and spinal cord trauma: Failure to confirm previous observations. Surg. Neurol., 2:5-11, 1974.

26. de la Torre, J.C., Johnson, C.M., Goode, D. and Mullan, S.: Chemotherapeutic

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reversal of experimental paraplegia. Neurology, 24:387, 1974.

27. de la Torre, J.C. and Rowed, D.W.: DMSO: A new respiratory stimulant? J. Clin. Pharmacol., 14:345-353, 1974.

28. de la Torre, J.C., Kawanaga, H.M., Goode, D.J., Johnson, C.M., Kajihara, K., Rowed, D.W. and Mullan, S.: Dimethyl sulfoxide in CNS trauma. Ann. N.Y. Acad. Sci., 243:362-389, 1975.

29. de la Torre, J.C., Johnson, C.M., Goode, D.J. and Mullan, S.: Pharmacological treatment and evaluation of permanent spinal cord trauma. Neurology, 25:504-514, 1975.

30. de la Torre, J.C., Kawanaga, H.M. and Mullan, S.: Treatment of experimental middle cerebral artery occlusion. Neurology, 25:383-384, 1975.

31. de la Torre JC, Hill PK, Gonzalez-Carvajal M, Parker JC. Transected spinal cord axons regenerate into collagen bioimplant. Birth Defects Orig Artic Ser. 1983;19(4):515-20

32. de la Torre, J.C.: Evidence for central innervation of intracerebral blood vessels: Local cerebral blood flow measurements and histofluorescent analysis by the SPG method. Neuroscience, 1:445-457, 1976.

33. de la Torre, J.C., Hill, P., Surgeon, J.W. and Mullan, S.: Experimental therapy after middle cerebral artery occlusion in monkeys. Surg. Forum, 26:489-492, 1975.

34. de la Torre, J.C. and Hill, P.K.: Ultrastructural formation for edema and its treatment following experimental brain infarction in monkeys. In: Dynamics of Brain Edema. H. Pappius and W. Feindel (eds.). Springer Verlag, New York, pp. 306-314, 1976.

35. de la Torre, J.C. and Surgeon , J.W.: A methodological approach to rapid and sensitive monoamine histofluorescence using a modified glyoxylic acid technique: The SPG method. Histochemistry, 49:81-93, 1976.

36. de la Torre, J.C.: A versatile drug for CNS injuries. Univ. Chicago Rep., 26:1-3, 1977.

37. de la Torre, J.C.: Neurophysiology of movement disorders. In: Parkinson's Disease. Neurophysiological, Clinical and Related Aspects. F.S. Messiha and A.D. Kenny (eds.). Plenum Press, New York, pp. 109-130, 1977.

38. de la Torre, J.C. and Surgeon, J.W.: Histochemical fluorescence of tissue and brain monoamines. Results in l8 minutes using the SPG method. Neuroscience,

30

1:451-454, 1976.

39. de la Torre, J.C. and Surgeon, J.W.: Dexamethasone and DMSO in cerebral infarction. Stroke, 7:577-583, 1976.

40. de la Torre, J.C. and Hill, P.K.: Angiographic and ultrastructural changes in monkey brain following experimental middle cerebral artery infarction. Stroke, 8:6-7, 1977

41. de la Torre, J.C., Surgeon, J.W. and Walker, R.H.: Effects of locus coeruleus stimulation on cerebral blood flow in selected brain regions. Acta Neurol. Scand., 56 (Suppl. 64):104-105, 1977.

42. de la Torre, J.C.,Surgeon, J.W., Hill, P.K. and Khan, T.: DMSO in the treatment of brain infarction: Basic considerations. In: Arterial Air Embolism and Acute Stroke. J.M. Hallenbeck and L. Greenbaum (eds.). Undersea Medical Society, Report No. 11-15-77, Bethesda, pp. 138-161, 1977.

43. de la Torre, J.C.: Somatosensory evoked potentials for the prognosis of coma in humans. Exp. Neurol., 60:304-317, 1978.

44. de la Torre, J.C.: Axonal catecholamines following subdural brain trauma: Examination using an improved SPG histofluorescence method. In: Catecholamines: Basic and Clinical Frontiers. E. Usdin, I. Kopin and J. Barchas (eds.). Pergammon Press, N.Y., Vol. 2, pp. 1307-1309, 1979.

45. de la Torre, J.C.: Chemotherapy of spinal cord trauma. In: The Spinal Cord and Its Reactions to Traumatic Injury. Ed. W. Windle, Marcel Dekker, New York, 291-310, 1980.

46. de la Torre, J.C. and Boggan, J.E.: Spinal cord injury and physiological recordings in the rat. Exp. Neurol., 70:356-370, 1980.

47. de la Torre, J.C.: Local cerebral blood flow following stimulation of locus coeruleus in monkeys and rats. In: Neurogenic Control of the Brain Circulation. Ch. Owman and L. Edvinsson (eds.). Pergamon Press, New York, pp.443-454, 1977.

48. de la Torre, J.C. and Surgeon, J.W., Ernest, T. and Wollmann, R.: Chronic intravenous toxicity of dimethyl sulfoxide in rhesus monkeys. J. Toxicol. Environ. Health, 7:49-57, 1981.

49. de la Torre, J.C.: Standardization of the SPG method for tissue monoamines.

31

Neurosci. Lett., 17:339-340, 1980.

50. Hayashi, N., de la Torre, J.C. and Green, B.A.: Regional spinal cord blood flow and tissue oxygen content after spinal cord trauma. Surg. Forum, 31:461-463, 1980.

51. de la Torre, J.C.: An improved approach to histofluorescence of tissue monoamines. J. Neurosci. Meth., 3:1-5, 1980.

52. Callahan, R.A., Klose, J. and de la Torre, J.C.: Acute spinal cord injury: Current Concepts. Clin. Orthop. 154:125-135, 1980.

53. de la Torre, J.C.: DMSO research in CNS trauma. U.S. Gov't. Printing Office, Washington, D.C., Comm. Pub. No. 96, 232, pp. 40-50, 1980.

54. de la Torre, J.C.: Spinal cord injury: Review of basic and applied research. Spine, 6:315-335, 1981.

55. de la Torre, J.C.: Can somatosensory evoked potentials diagnose brain death? In: Evoked Potentials, Sandoz Editions, Lyon, pp. 91-92, 1980.

56. de la Torre, J.C. and Gonzalez-Carvajal, M.: Steady state drug or fluid delivery to injured or transected spinal cord. Lab. Anim. Sci., 31:701-703, 1981.

57. de la Torre, J.C.: Evaluation of brain death using somatosensory evoked potentials.

58. Biol. Psychiat., 16:931-935, 1981.

59. de la Torre, J.C.: Catecholamine fiber regeneration across a collagen bioimplant after spinal cord transection. Brain Res. Bull. 9:545-552, 1982.

60. de la Torre, J.C.: Toxicity of dimethyl sulfoxide. Lancet, 1:157-158, 1981.

61. Hill, P.K., de la Torre, J.C. and Thompson, S.: A comparative study of E-M fixation procedures for the adult rat spinal cord based on regional blood flow. J. Neurosci. Meth., 5:23-31, 1982.

62. de la Torre, J.C.: Spinal cord injury models. Progr. Neurobiol., 22:289-344, 1984.

63. de la Torre, J.C., Hill, P.K., Gonzalez-Carvajal, J. and Parker, J.C.: Transected spinal cord axons regenerate into collagen bioimplant. In: Nervous System Regeneration. Alan R. Liss, 515-520, 1983.

64. de la Torre, J.C.: Role of DMSO in prostaglandin-thromboxane and platelet

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systems after cerebral ischemia. Ann. N.Y. Acad. Sci., 411:293-308, 1983.

65. Hill, P.K. and de la Torre, J.C.: Ultrastructural features of rat fasciculi gracilis unmyelinated fibers after contusion and DMSO treatment. Ann. N.Y. Acad. Sci. 411:200-217, 1983.

66. de la Torre, J.C.: A stochastic model for the study of stroke. Prostaglandins & Leukotrienes. J.M. Bailey (ed.). Plenum Press, NY, pp. 97-98, 1984.

67. de la Torre, J.C., Hill, P.K., Gonzalez-Carvajal, M. and Parker, J.C.: Evaluation of transected spinal cord regeneration in the rat. Exp. Neurol., 84:186-206, 1984.

68. de la Torre, J.C.: Diazepam and caffeine: An effective combination in migraine. Headache, 24:163-164, 1984.

69. de la Torre, J.C., Richard, M.T. and Ivan, L.: Experimental problems in spinal cord neural reconstruction. In: Processes of Recovery From Neural Trauma. Springer-Verlag, Berlin, pp. 317-325, 1986.

70. de la Torre, J.C., Richard, M.T. and Ivan, L.P.: The TILT formula for CNS lesions: Effects of DMSO. In: DMSO, Die Anwendung in der Medizin. Springer-Verlag, pp. 48-53, 1985.

71. Shipley, M., Halloran, F. and de la Torre, J.C.: Surprisingly rich projection from locus coeruleus to the olfactory bulb in the rat. Brain Res., 329:294-299, 1985.

72. Trauner, D.A. and de la Torre, J.C.: Effect of octanoate on blood-brain barrier permeability using L-dopa as a marker. Pediat. Neurol., 1:223-225, 1985.

73. Goyal, R. Karaca, M. and de la Torre, J.C.: Nerve regeneration using a collagen matrix bioimplant. Surg. Forum, 37:500-502, 1986.

74. de la Torre, J.C., Fortin, T. and Richard, M.: Pharmacological manipulation of acute brain ischemia. In: Treatment of Stroke, V. Lombardi (ed), Venezia Press, pp. 28-30, 1987.

75. de la Torre, J.C., Karaca, M., Merali, Z., Fortin, T. and Richard, M.: Laser or razor? A novel experimental peripheral nerve repair technique. Neurosurgery, 22:531-539, 1988.

76. de la Torre, J.C., Karaca, M., Merali, Z., Fortin, T. and Richard, M.: Five factors that may aid crushed rat sciatic nerve reconnection. Neurol. Neurobiol., 38:190-192, 1988.

77. de la Torre, J.C., Morassutti, D., Fortin, T. and Richard, M.: Associated

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norepinephrine loss following calcium-induced spinal paralysis. Brain Res., 442:197-204, 1988.

78. de la Torre, J.C.: The TILT formula for brain lesions. Med. Hypoth., 27:339-343, 1988.

79. de la Torre, J.C.: Die Behandlung von Schadel-und Rucken-markstraumen mit Dimethylsulfoxid. In DMSO. Z. Verlag, Munich, pp. 61-67, 1988.

80. de la Torre, J.C. and Goldsmith, H.S.: Increased blood flow enhances axon regeneration after spinal transection. Neurosci. Lett., 94:269-273, 1988.

81. Karaça, M., de la Torre, J.C., Goyal, R., Lach, B. and Benoit, B.: Rat sciatic nerve regeneration using a collagen bioimplant. Turk. Neurosurg., 1:4-11, 1989.

82. de la Torre, J.C. and Goldsmith, H.: Increased blood flow augments CNS axon regeneration. In: Biomedical Advances in Aging. (A.L. Goldstein, C. Gajdusek, C.J. Gibbs, eds.). Plenum Press, New York, pp. 477-484, 1990.

83. de la Torre, J.C. and Goldsmith, H.: Experimental reconstruction of transected spinal cord using a collagen-pedicle omentum graft. Acta Neurochirur., 102:152-163, 1990.

84. de la Torre, J.C. and Goldsmith, H.S.: Can CNS axons be bribed into regeneration? In: The Omentum, Springer-Verlag, N.Y. pp. 63-73, 1990.

85. Saunders, J.K., Smith, I.C.P., Butler, K., Preston, E., Haas, N. and de la Torre, J.C.: 31P-MRS and blood-brain barrier permeability studies of rat brain following ischemic insults. Proc. Soc. Magn. Reson. Med., 2:1026-1027, 1990.

86. de la Torre, J.C. and Fortin, T.: Partial or global rat brain ischemia. The SCOT model. Brain Res. Bull., 26:365-372, 1991.

87. de la Torre, J.C.: Synergic activity of combined prostacyclin-dimethyl sulfoxide in experimental brain ischemia. Can. J. Physiol. Pharmacol., 69:191-198. 1991.

88. de la Torre, J.C., Saunders, J., Fortin, T., Butler, K. and Richard, M.: Return of ATP/PCr and EEG after 75 minutes of global brain ischemia. Brain Res., 542:71-76, 1991.

89. Karaca, M., Bilgin, U., Akar, M. and de la Torre, J.C.: Dimethyl sulfoxide lowers ICP after closed head trauma. Eur. J. Clin. Pharmacol., 40:113-114, 1991.

90. Goldsmith, H.S. and de la Torre, J.C. Collagen:omentum graft review. Acta Neurochir, 106:89-91, 1991.

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91. Harman, K., Katnick, J. and de la Torre, J.C.: A quick and accurate line-sampling technique to quantify myelinated axons in peripheral nerve cross-sections. J. Neurosci. Meth., 38:107-110, 1991.

92. Harman, K., Katnick, J., Lim, R., Zaheer, A. de la Torre, J.C.: Glia maturation factor stimulates axon regeneration in transected rat sciatic nerve. Brain Res., 564:332-335, 1991.

93. de la Torre, JC, Goldsmith, HS: Supraspinal fiber outgrowth and apparent synaptic remodeling across transected-reconstructed feline spinal cord. Acta Neurochir., 114:118-127, 1992.

94. de la Torre, J.C., Fortin, T., Saunders, J.K., Butler, K. and Richard, M.: The no-reflow phenomenon is a post-mortem artifact. Acta Neurochir., 115:37-42, 1992.

95. de la Torre, J.C., Fortin, T., Park, G., Butler, K., Kozlowski, P., Pappas, B., de Socarraz, H., Saunders, J. and Richard, M.: Chronic cerebrovascular insufficiency induces dementia-like deficits in aged rats. Brain Res., 582:186-195, 1992.

96. de la Torre, J.C., Fortin, T., Park, Saunders, J., Kozlowski, P., Butler, K., de Socarraz, H., Pappas, B. and Richard, M.: Aged but not young rats develop metabolic, memory deficits after chronic brain ischemia. Neurol. Res. 14 (Suppl.), 177-180, 1992.

97. Goldsmith, H.S. and de la Torre, J.C.: Axonal regeneration after spinal cord transection and reconstruction. Brain Res., 589:217-224, 1992.

98. de la Torre, J.C.: La defaillance de la microhémodynamique cérébrale peut-elle provoker la maladie d'Alzheimer? Alzheimer Actualités, 75:6-7, 1993b.

99. de la Torre, J.C. and Mussivand, T.: Can disturbed brain microcirculation cause Alzheimer's disease? Neurol. Res., 15:146-153, 1993a..

100. de la Torre, J.C., Fortin, T., Park, G., Pappas, B., Saunders, J. and Richard, M.: Brain blood-flow restoration "rescues" chronically damaged rat CA1 neurons. Brain Res. 623:6-15, 1993.

101. de la Torre, J.C. and Goldsmith, H.S.: Coerulo-spinal fiber regeneration in transected feline spinal cord. Brain Res. Bull. 35:413-417, 1994.

102. de la Torre, J.C. and Fortin, T.: A chronic physiological rat model of dementia. Behavior. Brain Res., 63:35-40, 1994.

103. de la Torre, J.C.: Impaired brain microcirculation may trigger Alzheimer's disease.

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Neurosci. Behav. Rev., 18:397-401, 1994.

104. de la Torre, J.C.: Treatment of head injury in mice using fructose 1,6-diphosphate-dimethyl sulfoxide combination. Neurosurgery, 37:273-279, 1995.

105. de la Torre, J.C., Fortin, T. and Saunders, J.: Correlates between NMR spectroscopy, diffusion weighted imaging and CA1 morphometry following chronic brain ischemia. J. Neurosci. Res. 41:238-245, 1995

106. Pappas, B.A., de la Torre, J.C., Davidson, C., Keyes, M., Fortin, T: Chronic reduction of cerebral blood flow in the adult rat: late emerging CA1 cell loss and memory dysfunction. Brain Res. 708:50-58, 1996.

107. de la Torre, J.C., Pappas, B.A., Fortin, T, Keyes, M, Davidson, C: Progressive neurodegeneration in rat brain after chronic 3-VO or 2-VO. In:

Neurodegenerative Diseases, G. Fiskum ed., Plenum Press, NY, pp. 77-84, 1996

108. de la Torre, J.C.: Screening for "white coat" hypertension. J. Hypertension, 14:1047-1048, 1996

109. de la Torre, J.C.: Omental transposition for Alzheimer's disease. Neurol. Res. 18:295-296, 1996

110. de la Torre, J.C., Nelson, N., Sutherland, R.J.: Combined fructose 1,6-diphosphate-dimethyl sulfoxide reverses chronic memory deficits in brain ischemic rats. In: Neurochemistry. A. Teelken and J. Korf, eds, Plenum Press, NY, pp. 173-176, 1997

111. de la Torre, J.C. Cerebromicrovascular pathology in Alzheimer's disease and normal aging. Gerontology, 43:26-43, 1997

112. de la Torre JC, Hachinski V.: The long search. Ann NY Acad Sci 826:xiii-xiv, 1997

113. de la Torre, J.C.: Cerebrovascular changes in the aging brain. Adv. Cell and Aging Gerontol. 2:77-107, 1997

114. de la Torre, J.C.: Hemodynamics of deformed microvessels in Alzheimer's disease brain. Ann. N.Y. Acad. Sci. 826:75-91, 1997

115. de la Torre JC, Cada A, Nelson N, Davis G, Sutherland RJ, Gonzalez-Lima F. Reduced cytochrome oxidase and memory dysfunction after chronic brain ischemia in aged rats. Neurosci Lett. 223(3):165-8, 1997

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116. Pappas, B.A., Davidson, C., Bennett, S.A.L., de la Torre, J.C., Fortin, T., Tenniswood, M.: Chronic ischemia: Memory impairment and neural pathology in the rat. Ann. N.Y. Acad. Sci., 826:498-501, 1997

117. de la Torre, J.C., Hachinski, V.: CVPAD Conference Review. Neurobiol. Aging, 18:453-454, 1997

118. de la Torre, J.C., Nelson, N., Sutherland, R.J., Pappas, B.A.: Reversal of ischemic-induced chronic memory dysfunction in aging rats with a free radical scavenger-glycolytic intermediate combination. Brain Res., 779:285-288, 1998

119. Abdollahian, N.P., Cada, A., Gonzalez-Lima, F., de la Torre, J.C.: Cytochrome oxidase: A predictive marker of neurodegeneration. In: Cytochrome Oxidase in Neuronal Metabolism and Alzheimer’s Disease. Plenum Press, New York, pp. 233-261, 1998

120. de la Torre, J.C.: A toxicologic fishing expedition without the fish. Forensic Science Intern. 94:219-221, 1998

121. Goldsmith, H.S., de la Torre, J.C.: Omental-collagen repair of transected feline spinal cord. In: The Omentum: Application to Brain and Spinal Cord. Forefront Press, New Haven, CT, pp. 61-75, 2000.

122. de Jong, G.I., Farkas, E., Plass, J., de la Torre, J.C., Luiten, PGM.: Cerebral hypoperfusion yields capillary damage in hippocampus CA1 that correlates to spatial memory impairment. Neuroscience, 91:203-210, 1999.

123. de la Torre JC. Collagen-omentum reconstructive approach. J Neurotrauma. 16(8):747-748, 1999

124. de la Torre, JC: Critical threshold cerebral hypoperfusion causes Alzheimer’s disease. Acta Neuropathol 98:1-8, 1999

125. de la Torre, JC: Brain trauma in the elderly. In: Pathology of the Aging Nervous System, S. Duckett, J.C. de la Torre (eds.), Oxford Univ. Press, pp 458-473, 2001

126. de la Torre, JC: Critically attained threshold of cerebral hypoperfusion: The CATCH hypothesis of Alzheimer’s pathogenesis. Neurobiol. Aging, 903:424-436, 2000

127. de la Monte, SM, de la Torre, JC: Basic mechanisms of neurodegeneration in dementia. In: Pathology of the Aging Human Nervous System, S. Duckett, J.C. de la Torre (eds.), Oxford University Press, pp. 123-155, 2001

128. de la Torre, JC: Cerebral hypoperfusion and cognitive function: Can it lead to

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Alzheimer’s disease? Alzheimer Dis. Assoc. Disord, 14 (Suppl 1):S72-S81, 2000

129. de la Torre, JC: Critically attained threshold of cerebral hypoperfusion (CATCH): Can it cause Alzheimer’s disease? Ann NY Acad Sci 903:424-436, 2000

130. de la Torre, JC: Impaired cerebromicrovascular perfusion: Summary of evidence in support of its causality in Alzheimer’s disease. Ann NY Acad Sci, 924:136-152, 2000

131. Cada A, de la Torre JC, Gonzalez-Lima F. Chronic cerebrovascular ischemia in aged rats: effects of brain metabolic capacity and behavior. Neurobiol Aging 21:225-234, 2000

132. de la Torre JC, Stefano GB. Evidence that Alzheimer’s disease is a microvascular disorder: Role of constitutive nitric oxide. Brain Res Rev. 34:119-136, 2000

133. de la Torre, J.C and Fay, L.: Effects of aging on the human nervous system. In: Principles and Practice of Geriatric Surgery. R.A. Rosenthal, M. Zenilman, M. Katlic (Eds.), Springer-Verlag, New York, pp. 926-948, 2001

134. Karaca M, Kilic E, Yazici B, Demir S, de la Torre JC. Ischemic stroke in elderly patients treated with a free radical scavenger-glycolytic intermediate compound. Neurol Res, 24:73-80, 2002

135. de la Torre JC: Alzheimer’s disease as a vascular disorder: Nosological evidence. Stroke 33:1152-1162, 2002

136. de la Torre JC, Kalaria RN, Nakajima K, Nagata K. Preface to Alzheimer’s disease: Vascular etiology and pathology. Ann NY Acad Sci 977:xiii-xv, 2002

137. de la Torre JC: Alzheimer’s disease: how does it start? J. Alzheimer’s Dis., 4(6):497-512, 2002

138. de la Torre JC: Vascular basis of Alzheimer’s pathogenesis. Ann NY Acad Sci, 977: 196-215, 2002

139. de la Torre JC, Pappas BA, Prevot V, Emmerling M, Fortin T, Stefano GB. Hippocampal nitric oxide upregulation precedes memory loss and A1-40

accumulation after chronic brain hypoperfusion in rats. Neurol. Res. 25: 635-641, 2003.

140. de la Torre JC: Alzheimer’s disease is a vasocognopathy: A new term to describe its nature. Neurological Res. 26(5):517-524, 2004.

141. de la Torre JC: Is Alzheimer’s a neurodegenerative or a vascular disorder? Data,

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dogma and dialectics. Lancet Neurology, 2004, 3:184-190

142. Aliev G, Smith MA, de la Torre JC, Perry G: Role of vascular hypoperfusion-induced oxidative stress and mitochondria failure in the pathogenesis of Azheimer disease. Neurotox Res. 2003;5(7):491-504.

143. Aliev G, Smith MA, de la Torre, JC, Perry G. Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels as a central target for the development of human AD and AD-like pathology in aged transgenic mice. In: Vascular Dementia, Monduzzi Editore, Bologna, Italy, pp. 9-20, 2004

144. Aliyev A, Seyidova D, Obrenovich ME, Lamb BT, Smith MA, Perry G, de la Torre JC, Aliev G. Is nitric oxide a key target in the pathogenesis of brain lesions during the development of Alzheimer’s disease? Neurol Res. 26(5):547-553, 2004

145. Goldsmith HS, de la Torre JC. Vascular dynamics in Alzheimer and vascular dementia. Neurol Res. 2004;26(5):453-454

146. Seyidova D, Aliyev A, Rzayev N, Obrenovich M, Lamb BT, Smith MA, de la Torre JC, Perry G, Aliev G. The role of nitric oxide in the pathogenesis of brain lesions during the development of Alzheimer's disease.  In Vivo 18 (3): 325-333, 2004

147. de la Torre JC, Aliev G. Inhibition of vascular nitric oxide after rat chronic brain hypoperfusiion: Spatial memory and immunocytochemical changes. J Cerebral Blood Flow Metab. 25:663-672, 2005

148. de la Torre JC, Aliev G, Perry G. Drug therapy in Alzheimer's disease. New Eng J Med, 351:1911-1913, 2004

149. Aliev G, Obrenovich ME, Seyidova D, de la Torre, JC. Exploring ischemia-induced vascular lesions and potential pharmacological intervention strategies. Histol Histopathol 20:261-273, 2004

150. Aliev G, Smith MA, de la Torre JC, Perry G. Mitochondria as a primary target for vascular hypoperfusion and oxidative stress in Alzheimer’s disease. Mitochondrion 4/56:1-15, 2004

151. Aliyev A, Chen SG, Seyidova D, Smith MA, Perry G, de la Torre JC, Aliev G. Mitochondria DNA deletions in atherosclerotic hypoperfused brain microvessels as a primary target for the development of Alzheimer’s disease. J Neurol Sci, 229-230:285-292, 2005

152. de la Torre JC: Vascular nitric oxide: A key molecule in Alzheimer’s disease pathogenesis. In: Recent Progress in Alzheimer’s and Parkinson’r Diseases. I

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Hanin, Cacabelos R, Fischer, R. (eds.), Taylor & Francis, New York, pp153-166, 2005

153. de la Torre JC. Is Alzheimer’s disease preceded by neurodegeneration or cerebral hypoperfusion? Annals Neurol 57(6):783-784, 2005

154. Liu Q, Smith MA, Avilá J, DeBernardis J, Aliev G, de la Torre JC, Ghanbari HA, Siedlak SL, Harris P, Sayre L, Perry G. Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations. Free Radical Biol Med 78: 746-754, 2005

155. de la Torre JC. Cerebrovascular gene linked to Alzheimer’s disease. Trends Mol Med 11(12):534-536, 2005

156. Obrenovich, M.E., Siedlak SL, Smith, M.A., Chen S., de la Torre, J. C., Perry, G. and Aliev, G. Overexpression of GRK2 in Alzheimer disease and in a chronic hyperperfusion rat model is an early marker of brain mitochondrial lesion. Neurotoxicity Res, 10:43-56, 2006

157. de la Torre JC. How do heart disease and stroke become risk factors for Alzheimer’s disease? Neurol Res. 2006; 28(6):637-644,

158. de la Torre JC. The deadly triad: heart disease, stroke and Alzheimer’s disease. Neurol Res. 3006; 28: 577-578.

159. de la Torre JC. Vascular pathways to Alzheimer’s disease. Dementia Forum, 2 (March):2-6, 2007

160. de la Torre JC. Pathophysiology of neuronal energy crisis in Alzheimer’s disease. Neurodegenerative Dis.5(3-4),:126-132, 2008

161. Jacob SW, de la Torre JC. Pharmacology of dimethyl sulfoxide in cardiac and CNS damage. Pharmacol Rep 61:223-235, 2009

162. de la Torre JC. Alzheimer disease prevalence can be lowered with non-invasive testing. J Alz Dis 14(3):353-359, 2008

163. de la Torre JC. Knee-jerk dogma. J Amer Coll Surg. 204:762-63, 2008

164. de la Torre JC. Cerebrovascular and cardiovascular pathology in Alzheimer’s disease. Int. Rev Neurobiology of Dementia, 84:31-44, 2009.

165. de la Torre JC. Carotid artery ultrasound and echocardiography (CAUSE) testing to lower the prevalence of Alzheimer’s disease. J Stroke & Cerebrovasc Dis, 18:319-328, 2009

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166. de la Torre JC. Cerebral and cardiac vascular pathology in Alzheimer’s disease. In: R. Maccione and G. Perry (eds) Current hypotheses and research milestones in Alzheimer’s disease, Springer, pp 159-169, 2009

167. de la Torre JC. Postulates to help validate a causal relationship to Alzheimer’s disease. Frontiers Neurosci. May 2010, 4(1)

168. de la Torre JC. The vascular hypothesis of Alzheimer’s disease: Bench to bedside and beyond. Neurodeg Dis. 7:116-121, 2010

169. de la Torre JC. Alzheimer’s disease is incurable but preventable. Journal Alz Dis 20:861-870, 2010

170. de la Torre JC. Basics of Alzheimer’s disease prevention. Journal Alz Dis 20; 687-688, 2010

171. de la Torre JC. Vascular risk factor detection and control may prevent Alzheimer's disease. Ageing Res Rev. 9:218-225, 2010.

172. de la Torre JC: Three postulates to help identify the cause of Alzheimer’s disease. Journal Alz Dis, 24:657-668, 2011

173. de la Torre JC. Cardiovascular risk factors promote brain hypoperfusion leading to cognitive decline and dementia. Cardiovasc Psychiatry Neurol. 2012;2012:367516.

174. de la Torre JC. Preface: Physiopathology of vascular risk factors in Alzheimer's disease. J Alzheimers Dis. 2012;32(3):517-8.

175. de la Torre JC. Cerebral hemodynamics and vascular risk factors: setting the stage for Alzheimer's disease. J Alzheimers Dis. 2012; 32(3):553-67.

176. de la Torre JC. A turning point for Alzheimer's disease? Biofactors. 2012 Mar-Apr;38(2):78-83.

177. de la Torre JC. Vascular risk factors: a ticking time bomb to Alzheimer's disease. Am J Alzheimers Dis Other Demen. 2013 Sep;28(6):551-9.

178. Stone J, de la Torre JC. Alzheimer's disease is associated with increased risk of haemorrhagic stroke. Evid Based Ment Health. 2013 Aug;16(3):88.

179. de la Torre JC. In-house heart-brain clinics to reduce Alzheimer's disease incidence. J Alzheimers Dis. 2014;42 Suppl 4:S431-42.

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180. de la Torre JC. Detection, prevention, and pre-clinical treatment of Alzheimer's disease. J Alzheimers Dis. 2014;42 Suppl 4:S327-8.

181. de la Torre JC. Phase 3 trials of solanezumab and bapineuzumab for Alzheimer's disease. N Engl J Med. 2014 Apr 10;370(15):1459-60.

182. de la Torre JC. Cerebral perfusion enhancing interventions: A new strategy for the prevention of Alzheimer dementia. Brain Pathol. 2016 Sep;26(5):618-31.

183. de la Torre JC. Treating cognitive impairment with transcranial low level laser therapy. J Photochem Photobiol B. 2017 Mar;168:149-155.

184. de la Torre JC. Are major dementias triggered by poor blood flow to the brain? Theoretical considerations. J Alzheimers Dis. 2017;57(2):353-371.

185. de la Torre JC. Cardiac dysfunction and cognitive decline. Eur Heart J. 2017;38(8):584-585.

186. de la Torre JC. The vascular hypothesis of Alzheimer’s disease: A Key to Preclinical Prediction of Dementia Using Neuroimaging. J Alz Dis in press

Forum Discussion Organizer:

de la Torre JC: VASCULAR FACTORS IN ALZHEIMER’S DISEASE: ALZHEIMER’ S RESEARCH FORUM LIVE DISCUSSION. J. Alzheimer’s Disease, 6:673-681, 2004

Books and Edited Texts

1. de la Torre JC: Dynamics of Brain Monoamines. New York: Plenum Press, 1972.

2. de la Torre JC. (Ed.): Biological Actions and Medical Applications of DimethylSulfoxide. Annals N.Y. Acad. Sci., Vol. 411, 1983.

3. de la Torre JC and Gibson WC. (Eds.& Translators): S. Ramón y Cajal, TheNeuron and the Glial Cell. Charles C Thomas, 1984.

4. de la Torre JC and Hachinski, V. (Eds): Cerebrovascular Pathology in Alzheimer's Disease. Ann. N.Y. Acad. Sci., New York, vol. 826, 1997

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5. de la Torre JC (Ed.): Vascular Pathophysiology in Alzheimer’s Disease. Neurobiology of Aging, Elsevier, 21(1): 2000

6. Duckett S. and de la Torre JC (Eds.): The Pathology of the Aging Human Nervous System, 2nd Edition, Oxford University Press, 2001.

7. de la Torre JC, Kalaria RN, Nakajima K, Nagata K (Eds.): Alzheimer’s Disease: Vascular Epidemiology and Pathology. Ann NY Acad Sci, 977:1-535, 2002

8. Goldsmith HS and de la Torre JC (Eds.): Vascular Dynamics in Alzheimer and Vascular Dementia, Neurological Research Special Issue, 26(5):453-603, 2004

9. de la Torre JC. (Ed): Impact of Heart Disease and Stroke on Alzheimer’s Disease. Neurological Research Special Issue, 28(6), 2006

10. de la Torre JC. (Ed.): Basics of Alzheimer’s Disease Prevention. Special Issue, Journal Alz Dis. 20 (3), 2010

11. de la Torre JC )Ed) Physiopathology of Vascular Risk Factors in Alzheimer’s Disease. Special Issue, Journal Alz Dis 32 (3), 2012

12. de la Torre JC: (Ed) Alzheimer’s Disease Detection, Prevention and Preclinical Treatment. Special Issue, Journal Alz Dis 42 (4), 2014

Editor-in-Chief Editorials (Ottawa Neuroscience Newsletter)MRC cuts. Filopodia 1 (4) 2:1985

Evaluation of scientists. Filopodia 1 (5) 2:1985

A bias for action. Filopodia 1 (7) 2:1985

An endangered species. Filopodia 1 (8) 2:1985

A citadel of excellence. Filopodia 1 (9) 2:1985

Ungraceful aging. Filopodia 1 (10) 2:1985

Scientific warfare. Filopodia 2 (1) 2:1986

What's in a name. Filopodia 2 (2) 2:1986

Lectures: A necessary evil? Filopodia 2 (3) 2:1986

The myth of government priorities. Filopodia 2 (4) 2:1986

Does rat = monkey = humans? Filopodia 2 (5) 2:1986

Is survival just another word? Filopodia 2 (6) 2:1986

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Is MRC funding the wrong people? Filopodia 2 (7) 2:1986

The hottest science. Filopodia 2 (9) 2:1986

Never mind the brain. Filopodia 3 (2) 2:1987

Truth, and all that...! Filopodia 3 (5) 2:1987

BlogsTime to Dismount, Journal of Alzheimer’s Disease Editor’s Blog, October 30, 2015

What is Wrong With Alzheimer’s Disease Clinical Research, Journal of Alzheimer’s

Disease Editor’s Blog, February 10, 2017

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