CURRICULUM VITAE Edward V. Maytin, M.D. Ph.D. CITIZENSHIP: … · 2018-03-24 · CURRICULUM VITAE Edward V. Maytin, M.D. Ph.D. CITIZENSHIP: U.S.A. WORK ADDRESS: Clinical: Desk A61

CURRICULUM VITAE Edward V. Maytin, M.D. Ph.D. CITIZENSHIP: U.S.A. WORK ADDRESS:

Clinical: Desk A61 (Dermatology) Cleveland Clinic Foundation 9500 Euclid Avenue Cleveland, OH 44195 LRI: Department of Biomedical Engineering Lerner Research Institute, Mailstop ND-20 Cleveland Clinic Foundation, 9500 Euclid Avenue Cleveland, OH 44195 Tel: 216-445-6676 FAX: 216-444-9198 E-mail: [email protected] EDUCATION: 1974-1978 B.S. in Chemistry, 1978 Clarkson University, Potsdam, NY 1978-1984 Ph.D. in Radiation Biology and Biophysics, 1984 University of Rochester, Rochester, NY Advisor: Dr. Donald A. Young Thesis title: Gene expression after glucocorticoids, viral infection, and heat

shock in thymic lymphocytes 1978-1985 M.D. in Medicine, 1985 University of Rochester School of Medicine and Dentistry Rochester, NY PROFESSIONAL APPOINTMENTS: 1985-1986 Intern in Medicine, Roger Williams Hospital, Brown Univ, Providence, RI 1986-1987 Clinical and Research Fellow (Dermatology), Harvard Medical School 1987-1990 Resident in Dermatology, Harvard Medical School, Boston 1990-1993 Junior scientist, Cutaneous Biology Research Center, Massachusetts General Hospital, Dept of Dermatology, Boston 1993-1999 Research Fellow in Medicine (Endocrinology), Howard Hughes Medical Institute, Massachusetts General Hospital 1990-1995 Instructor of Dermatology, Harvard Medical School 1996-1999 Assistant Professor of Dermatology, Harvard Medical School 1990-1999 Assistant in Dermatology, Massachusetts General Hospital 1990-1999 Assistant in Molecular Endocrinology (Medicine), MGH 2000- current Full Staff in Dermatology (primary department), Cleveland Clinic 2000- 2012 Assistant Staff, Biomedical Engineering (secondary dept), Cleveland Clinic 2012- current Full Staff, Biomedical Engineering (secondary dept), Cleveland Clinic 2000- current Visiting Scientist, Dermatology, Massachusetts General Hospital, Boston, MA 2004- current Assistant Professor, Chem & Biomed Engineering, Cleveland State University 2005- current Assistant Professor, Dept of Molecular Med, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University (CCLCM), Cleveland, OH

Edward V. Maytin, page 2

CERTIFICATION and LICENSURE: 1986 Diplomate of the National Board of Medical Examiners 1986 Full Medical Licensure, Commonwealth of Massachusetts 1990 Full Medical Licensure, State of California 1990 Diplomate of the American Board of Dermatology 2000 Full Medical Licensure, State of Ohio HONORS and AWARDS: 1979-1985 Medical Scientist Training Program (MSTP) awardee PROFESSIONAL SOCIETY AFFILIATIONS: 1990- American Academy of Dermatology (AAD) 1990- Society of Investigative Dermatology (SID) 2003- American Association for Cancer Research (AACR) 2010- American Society of Phototobiology (ASP) 2008 Women's Dermatology Society 2009 International Photodynamic Association (IPA) 2009 Ohio Dermatology Association (ODA) 2009 Noah Worcester Dermatology Society PROFESSIONAL SERVICE: 1. Editorial Activities: Ad Hoc Journal review: Journal of Biological Chemistry Journal of Investigative Dermatology Cancer Research Matrix Biology Photochemistry and Photobiology Lasers in Surgery and Medicine 2. Grant Review/ Study Section Membership: DOD Special Grants on Ovarian cancer, Ad hoc reviewer, February 16, 2005 NIH SDRC (CWRU), Pilot & Feasibility Study grant review December 20, 2006 DOD Predoctoral Fellowship Awards, Ad hoc reviewer, July 6, 2004 VA RR&D Merit Grant Review Panel May 16, 2008 (wound healing) Office of Naval Research, Ad hoc review panel July 18, 2007 (wound healing) Ralph Wilson Med Research Foundation grants, reviewer, June 1, 2008 NIH RC1Challenge Grants (ARRA) Ad hoc reviewer April 24, 2009 VA RR&D Aging & Neurodegenerative Diseases review panel Feb 23-24, 2011 NIH Radiation Therapeutics and Biology Study Section: Sept 2012, May 2013, Oct 2013; Feb 2014; Oct 2014; Feb 2015; Mar 2016; Oct 2016. COMMITTEE SERVICE: 1. National/ International: American Society of Photobiology (ASP): member of Governing Council. International Photodynamic Association (IPA): member of Board of Directors 1. Harvard Medical School: Residency Selection Committee, Department of Dermatology, 1990-1996


2. Massachusetts General Hospital: Establishing Committee, Cutaneous Biology Research Center, 1990-93 Scientific Advisory Council, Mallinckrodt Center(GCRC), 1990-1996 Subcommittee on Research Animal Care (SRAC), 1999-2000 3. Cleveland Clinic/ Dermatology and Plastic Surgery (DPSI) Residency Selection Committee, Dermatology, 2005-2010 Education Committee, Dermatology, 2009-present Research Committee, Derm & Plastic Surgery Institute (Co-Chair), 2009-present 4. CCLCM: CCLCM Medical Student Admissions Committee, 2005-2006 CCLCM Medical Student Promotions & Review Committee (MSPRC), 2011-present 5. LRI: Biomedical Engineering, Internal Advisory Board, 2004-2008 Search Committee for Department of Cell Biology Chairman, 2011 EDUCATIONAL/ TEACHING ACTIVITIES 1. Curriculum/Course Development

The bulk of my effort (80%) is spent in translational research, both laboratory and clinical. The remaining 20% effort is spent on direct patient care. My research is devoted primarily to two topics: (1) photodynamic therapy of cancer, and (2) wound healing biology. These efforts are conducted primarily in my laboratory in the LRI, and secondarily in the clinics on Crile A61. In 2009, to begin to translate the basic science (preclinical) discoveries regarding photodynamic therapy of cancer from my laboratory into the clinic, I volunteered to establish and chair a Research Protocol Committee that evaluates and approves all clinical research protocols developed by faculty within the Dermatology and Plastic Surgery Institute (DPSI). In this way, I have learned the complexities and nuances of clinical research and am now in a better position to further not only my own clinical trials, but to help educate and guide my peers in these endeavors. Almost all of my activities involve supervision and teaching of junior scientists and physicians, either in my own laboratory (post-docs, graduate students, medical students) or in the Dermatology department (Residents doing research; see below). With this mix of academic activities in both the Lerner Research Institute and the Department of Dermatology, I continue to fulfill the role of Bridge Faculty for which I was hired in 2000. Dermatology Residency Research Track, Cleveland Clinic.

This curriculum/program was established in 2003 and was initiated by the then-Chairman of Dermatology (Philip Bailin) and myself; it has continued with the support of the current Chair (Allison Vidimos). The program's aim is to recruit one dermatology physician-fellow annually, who will commit to an extra year of residency training in which he/she learns translational research. So far (as of 2013) we have successfully trained the following individuals, as indicated: -- Past trainees (Year of completion): Chris Gasbarre, DO (2007); John Ebner, DO (2008); Golara Honari, MD (2009); Ron Feldman, MD PhD (2010); Angela Kyei, MD (2011); Natasha Atanaksova, MD PhD (2012); Sara Lohser MD (2013); Rayna Dyck, MD (2014); Shilpi Khetarpal, MD (2015).


Starting in 2014, we restructured the research experience to include opportunities for all residents in training. This was made possible by the improved infrastructure of our DPSI Research Committee (see above). All incoming PGY-2 residents receive Human Studies training and certification, and are required to identify a longitudinal preceptor and research project(s) that can be conducted an completed by the end of their residency. An educational activity, Dermatology Research Day, is held in June of each year, at which residents are asked to highlight their work in formal presentations. Awards are given, by majority vote, for the best research presentations of the year.

2. Teaching: Course, Institution, Year

2000-2015 Annual Clinic Seminars in Dermatology, Cleveland Clinic. “What’s New in Dermatologic Research?” I have given this CME lecture (an annual update of cutaneous biology literature) every year since 2001. Location: Cleveland Clinic Corporate Meeting Center (Beachwood), Kenneth Tomecki, M.D., course director.

2002 "Extracellular hyaluronan modulates cellular differentiation in rat keratinocyte lift

cultures," Symposium talk at L'Oreal Symposium on the Science and Technology of Skin Aging, Renaissance Hotel, Cleveland, OH. September 19, 2002.

2003 “Epidermis: Structure and Function." Faculty in North Coast Dermatology

Symposium,", Hilton Gateway Conference Center, Cleveland, OH. June 13, 2003. Kevin Cooper, M.D., course director

2003 “The Role of Dermatology in Diabetic Foot Care". Faculty in CME course

entitled "Diabetic Foot Care: Concepts and Controversies", Intercontinental Hotel and Conference Center, Cleveland, OH. November 15, 2003. Peter Cavanagh, Ph.D., course director

2003 “Artificial Skin: Problems and Promise". Invited faculty for course entitled

"Artificial Organs," Cleveland State University, Cleveland OH. November 19, 2003. Joanne Belovich, Ph.D., course director

2004 “The Role of Dermatology in Diabetic Foot Care," Faculty in CME course

entitled "Diabetic Foot Care: Concepts and Controversies", Williamsburg, VA Sept 17-18, 2004. Peter Cavanagh, Ph.D., and Jan Ulbrecht, M.D., course directors.

2004 “Clinical Opportunities in Wound Healing,” Faculty at NanoMedicine Summit,

Intercontinental Hotel and Conference Center, Cleveland, OH. Oct 25-26, 2004. Shuvo Roy, Ph.D., symposium organizer.

2005 “Interplay between biophysical and biochemical signals in wound healing”

Course lecture for graduate course EBME 408 Tissue and Cellular Engineering, Feb 3, 2005. Melissa Knothe-Tate, course director.

2005 “Dermatology of the Lower Extremity," Faculty in CME course entitled "Diabetic

Foot Care: Concepts and Controversies", Intercontinental Hotel and Conference Center, Cleveland, Oct 22, 2005. Peter Cavanagh, Ph.D., and Jan Ulbrecht, M.D., course directors.


2006 "Diabetic Foot Care: Concepts and Controversies." Faculty in CME course, Penn State University, State College PA, Nov 10, 2006. Peter Cavanagh, Ph.D., and Jan Ulbrecht, M.D., course directors.

2007 “Dermatological Research: What's Hot, What's Not." Invited course lecture for

the Ohio Dermatology Nurse Association, Hilton Conference Center, Columbus, OH. 20 Oct 2007.

2010 “Wound Healing: How Does it Work?" Guest lecturer for Cell and Tissue

Biology course," Cleveland State University, Cleveland, OH. Joanne Belovich, Ph.D., course director. 29 Nov 2010.

2011 “Wound Healing: An Elegant Example of Tissue Regeneration" Guest lecturer

for Cell and Tissue Biology course," Cleveland State University, Cleveland, OH. Joanne Belovich, Ph.D., course director. 28 Nov 2011.

2013 “Photodynamic Therapy in Difficult and High-Risk Patient Populations,” Course

director of Forum F052 at Annual Meeting of the American Academy of Dermatology, Miami Beach. 2 Mar 2013.

2013 “Lessons from a Patient with Grzybowski Syndrome (Multiple Eruptive

Keratoacanthomas)”, Lecture at the Noah Worcester Dermatological Society Annual Meeting. Waldorf Astoria Hotel, Orlando FL. 6 Apr 2013

2013 “Wound Healing: Tissues Working Together to Rebuild " Guest lecturer for Cell

and Tissue Biology course," Cleveland State University, Cleveland, OH. Joanne Belovich, Ph.D., course director. 27 Nov 2013.

2014 “Prospects for future adoption of photodynamic therapy as a mainstream

treatment of nonmelanoma skin cancer in the USA,” invited speaker at Annual Meeting of the SPIE (International Society of Photonics Engineers), San Francisco, CA. 2 Feb 2014.

2014 “Photodynamic Therapy in Difficult and High-Risk Patient Populations,” Course

director of Forum F075 at Annual Meeting of the American Academy of Dermatology, Denver, CO. 22 Mar 2014.

2014 “Enhancing PDT Efficacy: Pharmacological Methods,” lecture in Symposium

S052 at Annual Meeting of the American Academy of Dermatology, Denver, CO. 22 Mar 2014. Rolf-Markus Szeimies, course director.

2014 “Biopharmaceutical Manipulation to Improve Clinical Responsiveness of

Human Skin Cancers to Aminolevulinate-based Photodynamic Therapy, “ invited platform talk at the Eighth International Congress of Porphyrins and Pthalocyanines (ICPP-8), International Conference and Exhibition Center, Istanbul, Turkey. 24 June 2014.

2015 “Clinical potential for vitamin D as a neoadjuvant for photodynamic therapy of

nonmelanoma skin cancer,” invited speaker at Annual Meeting of the SPIE (International Society of Photonics Engineers), San Francisco, CA. 8 Feb 2015.


2015 “Clinical study of a painless PDT protocol for actinic keratoses of the face and scalp,” invited platform talk at 35th Annual Conference of American Society for Laser Medicine and Surgery (ASLMS), Kissimmee, FL. 24 Apr 2015.

2015 “HA regulation of inflammation and fibrosis in skin wounds,” invited platform talk

at 10th International Conference on Hyaluronan, Intenational Society for Hyaluronan Sciences (ISHAS), Florence, Italy. 9 June 2015.

3. Visiting Professorships 2000 Visiting Professor at Grand Rounds, CWRU, Skin Diseases Research Center,

Cleveland, OH. “What makes the skin thick or thin: Transcriptional control of epidermal differentiation" Kevin Cooper, program director. 14 Dec 2000.

2002 "Regulation of Epithelial Responses to Photodynamic Therapy: A New

Organotypic Model for Differentiation Related Effects," Visiting Lecturer, MGH Photomedicine Lecture, Massachusetts General Hospital, Boston, MA. Charles R. Lin, lectureship director. 26 June 2002.

2010 “Photodynamic Therapy,” Visiting professor at 15th Annual Introduction to

Cutaneous Biology course, Indiana University School of Medicine, Indianapolis, IN. Stephen Wolverton, course director. 5 Nov 2010.

2010 “Shedding New Light on Old Diseases: New Approaches to Photodynamic

Therapy,” Visiting Professor, Dermatology Department, University of Chicago, Chicago, IL. 10 Nov 2010 (Allan Lorincz Lecture).

2011 "Optically Targeted Therapy of Skin Cancer," invited faculty at Engineering in

Medicine: Redesigning Cancer Imaging and Therapy, Dartmouth College, Hanover, NH. Brian W. Pogue, symposium director. 11-13 July 2011.

2011 "Novel Differentiation Therapies for Enhancement of PDT," Organizer and

opening talk at Congress of the European Society of Photobiology/American Society of Photobiology (combined symposium on PDT), University of Geneva, Geneva, Switzerland, 2-6 September 2011.

2012 “Oncologic Indications and Aesthetic Applications of Photodynamic Therapy,"

invited lecture for Innovations & Multidisciplinary Perspectives in Cosmetic Surgery. James Zins, organizer. Ritz-Carlton Hotel, Fort Lauderdale, FL. Mar. 23-25, 2012.

2012 “Optimization of Photodynamic therapy for Actinic Keratoses." Invited lecture,

Annual meeting American Society for Laser Medicine and Surgery (ASLMS), Emil Tanghetti, course director. Orlando, FL, April 20, 2012.

2012 “The Science Behind Photodynamic Therapy,” invited lecture at 17th Annual

Intro to Cutaneous Biology course, Indiana University School of Medicine, Indianapolis, IN. Stephen Wolverton, course director. Nov. 16, 2012.

2015 “The Art and Science Behind Photodynamic Therapy,” invited lecture at 20th

Annual Intro to Cutaneous Biology course, Indiana University School of Medicine, Indianapolis, IN. Stephen Wolverton, course director. Nov. 7, 2015.


4. Thesis Committee: Who, Where, When (date)

As of 2015, I have served on CCLCM medical school research thesis committees for the students below, and for one a PhD student in the HHMI Molecular Medicine Scholars program (LRI). For three of the students (*), I was primary research mentor. James Beckman, CCLCM, 2/2/09 Influence of continuous local anesthetic infusion on tissue oxygenation after abdominal surgery. (mentor: Daniel Sessler, MD; CCF/Anesthesiology Outcomes Research) *Christine (Baran) Warren, CCLCM, 2/19/09 Prognostic markers for optimizing treatment responses to aminolevulinic acid photodynamic therapy of precancerous skin lesions and nonmelanoma skin tumors. (mentor: Edward Maytin, MD PhD; Dermatology) Beverly Jong, CCLCM, 4/13/09 Effect of hyperinsulinemic glucose control on delirium in post-cardiac surgery patients. (mentor: Andrea Kurz, MD; CCF/Anesthesiology Outcomes Research) Cathryn Zhang, CCLCM, 2/1/10 Association between psoriasis and metabolic syndrome in patients at the Cleveland Clinic (mentor: Elaine Husni, MD; CCF/Rheumatology) Patrick Blake, CCLCM, 3/4/10 CYLD: Clinical, genetic, epidermiological, and molecular investigations of Brooke-Spiegler syndrome and cutaneous appendageal carcinomas. (mentor: Jorge Toro, MD; NIH/NCI) Theresa Guo, CCLCM, 6/23/10 Seeking insight into metastatic melanoma through analysis of melanocyte development. (mentor: Glenn Merlino, PhD; NIH/NCI) *Akshat Paliwal, CCLCM, 2/15/11 Development and validation of a high frequency ultrasound-guided fluorescence tomography system to improve delivery of photodynamic therapy. (mentor: Edward Maytin, MD PhD; CCF/Dermatology) Donelle Cummings, CCLCM, 7/22/11 Evaluating the malignant potential of UV-irradiated melanocytes. (mentor: Glenn Merlino, PhD; NIH/NCI) David R. Hill, HHMI Graduate Scholars Program, 4/14/13 The role of hyaluronan in innate intestinal defense. (mentor, Carol de la Motte, PhD; CCF/Pathoiology). Fabrizio Galimberti, CCLCM, 8/17/215 Studies on dermatomyositis (mentor, Anthony Fernandez, MD PhD, CCF/Dermatology) Yumeng (Marina) Li, CCLCM (8/27/2015) Studies on macrophages and inflammation in murine dermatitis models (mentor, Nicole Ward, PhD, CWRU/University Hospitals, Dermatology)


5. Trainees a. Post-Doctoral Fellows trained

Alberto Passi, M.D. Ph.D., 2000-2001; Associate Professor of Pathology, Univ. Insubria, Varese, Italy Hiroko Kawamura, M.D., 2001-2002; Staff, Dept of Dermatology, Univ. Tokyo, Tokyo, Japan Mourad Bouras, Ph.D., 2001-2002; Assistant Professor, Univ. of Lyon, Lyon, France Enakshi Chakrabarti, Ph.D., 2002-2003; Postdoc Fellow, Univ. Rochester, Rochester, NY Sanjay Anand, Ph.D., 2003-2009, Project Scientist, Dept. Biomedical Engineering, CCF Monslow, James, Ph.D., 2005-2009; Associate Staff Scientist, The Wistar Institute, Philadelphia, PA Yan Wang, M.D. Ph.D., 2011- present;

b. Graduate Students trained

Gati Ajani, M.D., Graduate student, Cleveland State University (Applied Biomedical Engineering program); Ph.D. awarded May 10, 2008; currently a Gastroenterology Fellow at UCLA School of Medicine, Los Angeles, CA. Kirsi Rilla, Ph.D. graduate student co-mentor, Univ. of Kuopio (Dept Anatomy; Kuopio, Finland; Raija Tammi MD PhD, mentor); laboratory rotation (2 months), 2000 Sanna Pasonen, Ph.D., graduate student co-mentor, Univ. of Kuopio (Dept Anatomy; Kuopio, Finland; Raija Tammi MD PhD, mentor); laboratory rotation (2 months), 2002 Tina Jokela, Ph.D., Graduate student co-mentor, Univ. of Kuopio (Dept Anatomy; Kuopio, Finland; Raija Tammi MD PhD, mentor); laboratory rotation (3 months), 2006 Leena Rauhala, Ph.D., Graduate student co-mentor, Univ. of Kuopio (Dept Anatomy; Kuopio, Finland; Raija Tammi MD PhD, mentor); laboratory rotation (3 months), 2011 Kishore Rollakanti, Ph.D., Graduate student, Cleveland State University (Applied Biomedical Engineering program); Ph.D. in Engineering awarded May 9, 2015; currently working at a clinical trials data analysis company in Pennsylvania Sajina Shakya (PhD candidate, currently in Dr. Maytin’s laboratory).

c. Clinical Research Fellows trained Parrish Sadeghi, M.D., 2000-2001; currently in private practice in Colorado. Christopher Gasbarre, D.O., 2005-2006; currently in private practice, Spearfish, SD John Ebner, D.O., M.S., 2006-2007; currently in private practice, Phoenix, AZ


Howard Fein, M.D., 2006-2007; currently in private practice in Los Angeles, CA Golara Honari, M.D., 2007-2008; currently Kaiser Permanenti in Los Angeles, CA Ron Feldman, M.D. Ph.D., 2008-2009; currently an Assistant Professor of Dermatology, Emory University, Atlanta, GA Angela Kyei, M.D., 2009-2010; currently on faculty of Dept. Dermatology, Cleveland Clinic Natasha Atanaskova, M.D. Ph.D., 2010-2011; after research residency, did a fellowshiop in Dermatopathology (Wilma Bergfeld); on staff at Cleveland Clinic until 2015 Rim Ishak, M.D. 2012-2013; clinical research in photodynamic therapy; currently doing research at Washington University, St. Louis. Sara Lohser, M.D. (graduated 6/2013); currently in private practice in Solon, OH

d. Medical Students/Predoctoral Students trained including CCLCM thesis students. Benjamin Jamie Galen, M.D.; Strnad Undergraduate Fellowship, University School, Shaker Heights OH (3 months in summer 2000); now a Resident in Internal Medicine at Yale School of Medicine Julie Pruneski (Corbin), D.D.S., undergrad summer student (3 months in 2002); now in dental practice in Zanesville, OH Helen Chung, M.E., medical student from Albert Einstein, Bronx NY, research rotation at CCF (4 months in 2002); now in medical practice in Flagstaff, AZ Anokhi Jambusaria Pahlajani, M.D., medical student from Temple University Med School, research rotation (2 months in 2005); now in practice in Internal Medicine in Philadelphia, PA Brian Moore, M.D., medical student from Univ. Toledo, research rotations (3 months in 2005 and in 2007); now a Resident in Dermatology at the Cleveland Clinic Katherine C. Burt, M.D., undergrad summer student from Brown University, trained for 3 months in 2006 in the Research for Undergraduates (REU) program funded by the National Science Foundation. She graduated from U Texas, now Chief Resident in Dermatology, MetroHealth Center, Cleveland, OH. Ellen Lee, M.D., CCLCM medical student research rotation (2 months, summer 2006); now a Resident in Psychiatry, Sheppard Pratt, University of Maryland Medical Center, Baltimore, MD Dimitry Burdjalov, B.S., undergrad research rotation (3 months, summer 2007); currently in postgraduate (Ph.D.) program in Engineering at Stanford University Manu Raam, CCLCM medical student research rotation (2 months, 2007); graduating Class of 2012 Tatyana Petukovha, CCLCM medical student research rotation (2 months, 2009); graduating Class of 2013


*Christine (Baran) Warren, M.D. M.S., CCLCM medical student; thesis work 2007-2009; thesis defense on 2/19/2009; subsequently trained in Dermatology (Chief Resident), Yale School of Medicine; currently on faculty at Cleveland Clinic (Assoc Staff, Dermatology) *Akshat Paliwal, M.D., CCLCM medical student; thesis work 2009-2011; thesis defense on 2/15/2011; now a Resident in Diagnostic Radiology, Dartmouth Med School, Dartmouth, NH Clara Wilson, B.A., undergrad summer student from Ohio Univ at Miami, (3 months in 2009 and 3 months in 2010); currently in school to become a Physician Assistant (Tri-C college). Karthik Iyer, B.A., medical student from Northeast Ohio Universities College of Medicine, (NEOUCOM), 3 month research rotation in 2010; currently a medical intern at Akron General Nikoleta Brankov, B.S., Biology major at Youngstown State University, 5 month research rotation in 2011; currently a medical student at Loma Linda University. Erik Thomas, Bioengineering Major from Univ. Michigan, undergrad summer student in the Research for Undergraduates (REU) program, funded by the National Science Foundation) for 10 weeks in 2015.

e. Current trainees Sajina Shakya, B.A. Graduate student, Cleveland State University (ABE Program); enrolled in Fall 2012; thesis ongoing Yan Wang, M.D. Ph.D., Post-doctoral fellow, completed Ph.D. thesis at West Virginia Medical School, Morganstown, WV in 2011; started with Dr. Maytin 2011.

CURRENT FUNDING: 2015- Heart Lung Blood Institute (NIH) Program Project Grant 1 P01 HL107147 Project Leader: E. Maytin (Project 2) Principal Investigator: V. Hascall

Title: Hyaluronan Matrices in Vascular Pathologies Project 2: Hyaluronan in Cutaneous Inflammation and Fibrosis Total Direct Costs: (2011 - 2018): $1,724,570 2015- National Cancer Institute (NIH) Program Project Grant 5 P01 CA084203 Project Leader: E. Maytin (Project 1) Principal Investigator: T. Hasan (Mass General Hospital) Title: Molecular Response and Imaging-based Combination Strategies for Optimal PDT Project 1: Use of Differentiating Agents with PDT for Skin Cancer Total Direct Costs: (2015- 2020): ~$500,190 2015-16 National Cancer Institute (NIH) R21 CA187805 Principal Investigator: E. Maytin Title: Oral Vitamin D3 and Photodynamic Therapy of Epithelial Cancers Total Direct Costs: (7/1/14 - 6/30/16): $239,250 2015- DUSA/Sun Pharmaceuticals (Comprehensive Cancer Center Study# CASE 2614) Principal Investigator: E. Maytin

Title: “Pilot trial comparing two different wavelengths of light (blue versus red) during


LevulanTM-based photodynamic therapy of basal cell carcinoma (BCC) in patients with Basal Cell Nevus Syndrome”

Total Direct Costs: $94,719 2015- DUSA/Sun Pharmaceuticals Principal Investigator: E. Maytin

Title: “Simultaneous incubation/illumination versus short aminolevulinate preincubation for painless photodynamic therapy of actinic keratoses”

Total Direct Costs: $53,898 2015- Ohio Bio-Fund (University of Akron) Principal Investigator: E. Maytin Coinvestigators: Y. Liu, F. Papay

Title: “Evaluation of Integrated Imaging Goggles, a new fluorescence detection system: Pilot study to visualize actinic keratoses after topical application of 5-aminolevulinic acid” Total Direct Costs: $10,000

PREVIOUS FUNDING: 2014-15 Research Protocol Committee (Cleveland Clinic and DPSI) Principal Investigator: E. Maytin Title: Simultaneous Incubation Versus Traditional ALA Preincubation for Painless PDT Total Direct Costs: (7/1/14 - 6/30/15): $15,000 2013- National Cancer Institute (NIH) Program Project Grant 5 P01 CA084203 Project Leader: E. Maytin (Project 1) Principal Investigator: T. Hasan (Mass General Hospital) Title: Molecular Response and Imaging-based Combination Strategies for Optimal PDT Project 1: Use of Differentiating Agents with PDT for Skin Cancer Total Direct Costs: (2001 - 2006): $528,190 Total Direct Costs: (2009 - 2013): $602,170 2013- National Cancer Institute (NIH) R21 CA156227 Principal Investigator: E. Maytin Title: Combination therapy with 5-FU and PDT for the Treatment of Post-transplant Premalignant Skin Disease Total Direct Costs: (7/13/11 - 6/30/14 (no cost extension): $261,300 2009 NIAMS (NIH) NIH Director's Bridge Award R56 AR049249 Principal Investigator: E. Maytin Title: Hyaluronan and Epidermal Injury Responses Total Direct Costs: $215,000; 9/1/2001 - 8/31/2011 2004 NIAMS (NIH) 5 R01 AR049249 Principal Investigator: E. Maytin Title: Hyaluronan and Epidermal Differentiation Total Direct Costs: $728,000; 2/17/2004 - 1/31/2008 2003 NIAMS (NIH) Skin Disease Research Center Pilot Grant 5 P30 AR039750 Project Leader: E. Maytin Principal Investigator: K. Cooper Title: CHOP/GADD153 and UVB-induced Apoptosis in the Skin Total Direct Costs: $20,000; 5/1/2003 - 4/30/2004


2001 NCI (NIH) Program Project Grant P01 CA084203 Project Leader: E. Maytin (Project 1) Principal Investigator: T. Hasan (Mass General Hospital) Title: Physical and Biological Determinants for Optimal PDT: Project 1: Role of Cellular Differentiation in Photodynamic Therapy Total Direct Costs: $528,195; 8/9/2001 - 7/31/2006 1998 NIAMS (NIH) First Independent Research Support and Transition Award, 5 R29 AR45430 Principal Investigator: E. Maytin Title: C/EBPβ and CHOP in Epidermal Differentiation Total Direct Costs: $350,000; 8/20/1998 - 6/30/2003 1995 NIAMS (NIH) Clinical Investigator Award K08 AR01958 Principal Investigator: E. Maytin Title: Regulation of the K10 gene by C/EBPs in keratinocytes Total Direct Costs: $210,000; 1995-1998 1994 American Cancer Society, MGH IRG Principal Investigator: E. Maytin Title: Role of a putative tumor-suppressor gene, CHOP-10, in the regulation of apoptosis Total Direct Costs: $20,000; 1994-1995 1990 Dermatology Foundation Grant Principal Investigator: E. Maytin Title: Proteins induced by ultraviolet light or heat shock in keratinocytes Total Direct Costs: $10,000; 1990-1991 PENDING FUNDING: 2015- National Cancer Institute (NIH) Regular R01 Grant application 1 R01 CA204158 Principal Investigator: E. Maytin Title: Vitamin D and Photodynamic therapy for Human Skin Cancer (SCC and BCC) Total Direct Costs: (2016-2021): $1,561,025 TRAINEE AWARDS: Albert Kligman Foundation Travel Award (Sanjay Anand), International Investigative Dermatology Meeting, May 2008, Kyoto, Japan, $1000 Women's Dermatology Society fellowship grant (Ron Feldman), 2007, $8000 American Cancer Society Silber Fellowship (Christine Baran), 2008, Ohio Chapter ACS, $2500 American Society of Photobiology Travel Award (Kishore Rollakanti), 2014, $1,000 Cleveland State University Ph.D. Dissertation Award (Kishore Rollakanti), 2014, $5000 PEER REVIEWED PUBLICATIONS: 1. Maytin EV and Young DA. Separate glucocorticoid, heavy metal, and heat shock domains in

thymic lymphocytes. J Biol Chem 1983; 258:12718-12722.


2. Young DA, Voris BP, Maytin EV, Colbert RA. Very-high-resolution two-dimensional

electrophoretic separation of proteins on giant gels. Methods Enzymol 1983; 91:190-214. 3. Maytin EV, Balduzzi PC, Notter M, Young DA. "Changes in the synthesis and phosphorylation

of cellular proteins in chick fibroblasts transformed by two avian sarcoma viruses. J Biol Chem 1984; 259:12135-12143.

4. Maytin EV, Colbert RA, Young DA. Early heat shock proteins in primary thymocytes: Evidence

for transcriptional and translational regulation. J Biol Chem 1985; 260:2384-2392. 5 Levenson RM, Maytin EV, Young DA. Inexpensive microcomputer-based 2-D gel densitometry.

Analyt Biochem 1986; 158:294-301. 6. Levenson RM, Maytin EV, Young DA. A novel inexpensive method for 2-D gel densitometry.

BioTechniques 1987; 5:298-302. 7. Maytin EV, Levine JR, Dover JS. Life-threatening hemorrhage from a 4-mm punch biopsy site

in a patient with AIDS and hemophilia A. J Am Acad Dermatol 1989; 21:1033-1034. 8. Maytin EV, Wimberly J, Anderson RR. Thermotolerance and the heat shock response in normal

human keratinocytes. J Invest Dermatol 1990; 95:635-642. 9. Maytin EV, Levin E, Anderson RR. A laser densitometer for selected spot analysis on two-

dimensional dot blots and autoradiograms. Analyt Biochem 1991; 194:284-294. 10. Maytin EV, Horan RF, Dover JS. Tumorous nodules on the lower extremities. Arch Dermatol

1991; 127: 405-410. [case report on mastocytosis]. 11. Maytin EV. Differential effects of heat shock and UVB light upon stress protein expression in

epidermal keratinocytes. J Biol Chem 1992; 267: 23189-23196. 12. Maytin EV, Murphy LA, Merrill MA. Hyperthermia induces resistance to ultraviolet light (UVB) in

primary and immortalized epidermal keratinocytes. Cancer Research 1993; 53:4952-4959. 13. Maytin EV, Wimberly JM, Kane KS. Heat shock modulates UVB-induced cell death in human

epidermal keratinocytes: evidence for a hyperthermia-inducible protective response. J Invest Dermatol 1994; 103: 547-553.

14. Kane KS and Maytin EV. Ultraviolet B-induced apoptosis of keratinocytes in murine skin is

reduced by mild local hyperthermia. J Invest Dermatol 1995; 104: 62-67. 15. Maytin EV and Habener JF. Transcription factors C/EBPa, C/EBPb, and CHOP (gadd153)

expressed during the differentiation program of keratinocytes in vitro and in vivo. J Invest Dermatol 1998; 110: 238-246.

16. Ortel B, Chen N, Brissette J, Dotto GP, Maytin E, Hasan T. Differentiation-specific stimulation of

ALA-induced PPIX formation in keratinocytes. Br J Cancer 1998; 77:1744-51. 17. Maytin EV, Lin JC, Krishnamurthy R, Batchvarova N, Ron D, Mitchell PJ, and Habener JF.

Keratin 10 gene expression during differentiation of mouse epidermis requires transcription factors C/EBP and AP-2. Dev Biol 1999; 216: 164-181.


18. Maytin EV, Ubeda M, Lin JC, Habener JF. Stress-inducible transcription factor CHOP/gadd153 induces apoptosis in mammalian cells via p38 kinase-dependent and –independent mechanisms. Exper Cell Res. 2001; 267: 193-204.

19. Hamblin MR, Miller JL, Rizvi I, Ortel B, Maytin EV and Hasan, T. Pegylation of a chlorin(e6)

polymer conjugate increases tumor targeting of photosensitizer. Cancer Res. 2001; 61: p. 7155-7162.

20. Ortel B, Sharlin D, O'Donnell D, Sinha AK, Maytin EV, Hasan T. Differentiation enhances

aminolevulinic acid-dependent photodynamic treatment of LNCaP prostate cancer cells. Brit J Cancer 2002; 87:1321-1327.

21. Mack JA, Abramson SR, Ben Y, Coffin JC, Rothrock JR, Maytin EV, Hascall VC, Largman C,

and Stelnicki EJ. Hoxb13 knockout adult skin exhibits high levels of hyaluranon and enhanced wound healing. FASEB J. 2003; 17 (10): 1352-1354.

22. Passi A., Sadeghi P., Kawamura H., Anand S, Sato N, White LE, Hascall VC, Maytin EV.

Hyaluronan suppresses late markers of epidermal differentiation in organotypic cultures of rat keratinocytes. Exper Cell Res. 2004; 296: 123-134.

23. Maytin EV, Chung HH, Seetharaman VM. Hyaluronan participates in the epidermal response to

disruption of the permeability barrier in vivo. Am J Pathol 2004; 165:1331-1341. 24. Anand S, Chakrabarti E, Kawamura H, Taylor CR, Maytin EV. Ultraviolet light (UVB and UVA)

induces the damage-responsive transcription factor CHOP/gadd153 in murine and human epidermis: Evidence for a mechanism specific to intact skin. J Invest Dermatol 125: 323-333, 2005.

25. Mack JA, Ling L, Sato N, Hascall VC, Maytin, EV. Hoxb13 up-regulates transglutaminase

activity and drives terminal differentiation in an epidermal organotypic model. J Biol Chem 280: 29904-29911, 2005.

26. Fein H, Maytin EV, Mutasim DF, Bailin PL. Topical protease therapy as a novel method of

epidermal ablation: Preliminary report. Dermatol Surg 31 (Feb): 1-10, 2005 27. Woodhouse JG, Maytin EV. Eruptive nevi of the palms and soles. J Am Acad Dermatol 52

(May): S96-S100, 2005. 28. Sinha A, Anand S, Ortel BJ, Chang Y, Mai Z, Hasan T, Maytin EV. Methotrexate used in

combination with aminolevulinic acid for photodynamic killing of prostate cancer cells. Brit J Cancer 95:485-495, 2006.

29. Haverstock C, Libecco JF, Sadeghi P, Maytin E. Tender erythematous plaques in a woman with

acute myelogenous leukemia [Sweet's syndrome]. Arch Dermatol. 142(2) (Feb):235-240, 2006. 30. Sato N, Moore B, Keevey S, Drazba J, Hasan T, Maytin EV. Vitamin D enhances ALA-

mediated protoporphyrin IX production and photodynamic cell death in 3-D organotypic cultures of keratinocytes. J Invest Dermatol 127:925-934, 2007

31. Ajani G, Sato N, Mack JA, Maytin EV. Cellular responses to disruption of the permeability

barrier in a 3-dimensional organotypic epidermal model. Exper Cell Res 313(14):3005-3015, 2007.


32. Pasonen-Seppanen S, Maytin EV, Torronen K, Hyttinen JMT, Hascall V, MacCallum D, Kultti A, Jokela T, Tammi MI, Tammi RH. All-trans retinoic acid-induced hyaluronan production and hyperplasia are partly mediated by EGFR signaling in epidermal keratinocytes. J Invest Dermatol Apr;128(4):797-807, 2008.

33. Jokela TA, Lindgren A, Rilla K, Maytin E, Hascall VC, Tammi RH, Tammi MI. Induction of

hyaluronan cables and monocyte adherence in epidermal keratinocytes. Connect Tissue Res. 49:115-119, 2008.

34. Monslow J, Sato S, Mack JA, Maytin EV. Wounding-induced synthesis of hyaluronic acid in

organotypic epidermal cultures requires the release of heparin-binding EGF and activation of the EGF receptor. J Invest Dermatol, 2009; 129(8): 2046-2058.

35. Anand S, Honari G, Hasan T, Elson P, Maytin EV. Low-dose methotrexate enhances

aminolevulinate-based photodynamic therapy in skin carcinomacells in-vitro and in-vivo. Clin Cancer Res 2009; 15(10): 3333-3343, 2009.

36. Mack JA, Maytin EV. Persistent Inflammation and Angiogenesis during Wound Healing in K14-

Directed Hoxb13 Transgenic Mice. J Invest Dermatol 2010; 130:856-65. 37. GruberJD, Paliwal A, Maytin EV, Hasan T, Pogue BW. System development for high frequency

ultrasound-guided fluorescence quantification of skin layers. Journal of Biomedical Optics, 2010; 15(2) March/April, Issue 026028, pages 1-5. [DOI: 10.1117/1.3374040].

38. Warren CB, Lohser S, Wene LC, Pogue BW, Bailin PL, Maytin EV. Noninvasive fluorescence

dosimetry to define protoporphyrin IX production rates in actinic keratoses following short-contact application of 5-aminolaevulinate. J Biomedical Optics, 2010; 15(2) Sept/October, Issue 051607, pages1-8. [DOI: 10.1117/1.3484255].

39. Anand S, Wilson C, Hasan T, Maytin EV. Vitamin D3 enhances the apoptotic response of

epithelial tumors to aminolevulinate-based photodynamic therapy. Cancer Res. 2011; 71(18): 6040-50.

40. Mack JA, Feldman RJ, Itano N, Kimata K, Lauer M, Hascall VC, Maytin EV. Enhanced

Inflammation and Accelerated Wound Closure Following Tetraphorbol Ester Application or Full-Thickness Wounding in Mice Lacking Hyaluronan Synthases Has1 and Has3. J Invest Dermatol. 2012; 132: 198-207.

41. Maytin EV, Golara Honari G, Khachemoune A, Taylor CR, Ortel B, Pogue, BW, Nathaniel

Sznycer-Taub N, Hasan T, Small molecule enhancers of aminolevulinate (ALA)-mediated photodynamic therapy (PDT) for neoplastic and inflammatory skin diseases: Proof-of-principle study combining Vitamin D and ALA-PDT in human psoriasis. Israel J Chem 2012, 52:767-775.

42. Anand S, Hasan T, Maytin EV. Mechanism of Differentiation-Enhanced Photodynamic Therapy

for Cancer: Upregulation of Coproporphyrinogen Oxidase by C/EBP Transcription Factors. Mol Cancer Ther 2013; 12(8):1638-50. PMID: 23686770

43. Rollakanti K, Kanick SC, Davis SC, Pogue BW, Maytin EV. Photonics Lasers Med, Techniques

for fluorescence detection of protoporphyrin IX in skin cancers associated with photodynamic therapy. Photonics Lasers Med 2013; 2(4): 287-303.

44. Anand S, Rollakanti KR, Horst RL, Hasan T, Maytin EV. Combination of Oral Vitamin D3 with


Photodynamic Therapy Enhances Tumor Cell Death in a Murine Model of Cutaneous Squamous Cell Carcinoma. Photochem Photobiol. 2014 Sep-Oct;90(5):1126-35. PMID: 24807677

45. Kanick SC, Davis SC, Zhao Y, Hasan T, Maytin EV, Pogue BW, Chapman MS. Dual-channel

red/blue fluorescence dosimetry with broadband reflectance spectroscopic correction measures protoporphyrin IX production duringphotodynamic therapy of actinic keratosis. J Biomed Opt. 2014 Jul;19(7):75002. PMID: 24996661.

46. Wang Y, Lauer ME, Anand S, Mack JA, Maytin EV. Hyaluronan synthase 2 protects skin

fibroblasts against apoptosis induced by environmental stress. J Biol Chem. 2014 Nov 14; 289(46):32253-65. PMID: 25266724.

47. Anand S, Ebner J, Warren CB, Raam MS, Pilliang M, Billings SD, Maytin EV. C/EBP

transcription factors in human squamous cell carcinoma: Selective changes in expression of isoforms correlate with the neoplastic state. PLoS One, 2014 Nov 17; 9(11):e112073. PMID: 25402211

48. Rollakanti KR, Anand S, Maytin EV. Vitamin D enhances the efficacy of photodynamic therapy in

a murine model of breast cancer. Cancer Medicine, 2015 May; 4(5):633-42. PMID: 25712788. 49. Rollakanti K, Anand S, Maytin EV. Topical calcitriol prior to photodynamic therapy enhances

treatment efficacy in non-melanoma skin cancer mouse models. Proc SPIE Int Soc Opt Eng. 2015 Mar 2; 9308:93080Q. PMID: 25983370

50. Kanick SC, Davis SC, Zhao Y, KL Sheehan KL, Hasan T, Maytin EV, Pogue BW, Chapman MS.

Pre-treatment protoporphyrin IX concentration in actinic keratosis lesions may be a predictive biomarker of response to aminolevulinic-acid based photodynamic therapy. Photodiagnosis and Photodynamic Therapy. 2015 Oct 16, [E-pub ahead of print] PMID: 26480810.

51. Rollakanti K, Anand S, Davis SC, Pogue BW, Maytin EV. Noninvasive optical imaging of UV-

induced squamous cell carcioma in murine skin: Studies of early tumor development and Vitamin D enhancement of protoporphyrin IX production. Photochem Phototobiol 2015 Nov; 91(6):1469-78. PMID: 26223149

BOOK CHAPTERS/ PROCEEDINGS: 1. Maytin EV. Reactions to heat and cold. In: Olbricht SM, Bigby ME, Arndt KA, eds. Manual of

Clinical Problems in Dermatology. Boston: Little, Brown, and Co., 1992: 206-211. 2. Maytin EV. Cutaneous signs of internal malignancy. In: Olbricht SM, Bigby ME, Arndt KA, eds.

Manual of Clinical Problems in Dermatology. Boston: Little, Brown, and Co., 1992: 272-277. 3. Maytin EV. Warts. In: Olbricht SM, Bigby ME, Arndt KA, eds. Manual of Clinical Problems in

Dermatology. Boston: Little, Brown, and Co., 1992: 149-153. 4. Maytin EV. Contact dermatitis. In: Olbricht SM, Bigby ME, Arndt KA, eds. Manual of Clinical

Problems in Dermatology. Boston: Little, Brown, and Co., 1992: 250-256. 5. Maytin, EV. C/EBP transcription factors in epidermal keratinocytes are modulated during

normal differentiation and in response to cellular stress. In: Honigsmann H, Knobler RM, Trautinger F, Jori G, editors. Proceedings of the 12th International Congress on Photobiology; 1996 Sep 1-6; Vienna, Austria. Milan: OEMF; 1998. p. 267-271.


6. Passi A, Sadeghi P, Kawamura H, Hascall V, Maytin EV. Hyaluronan production is upregulated during keratinocyte differentiation in an organotypic model of the epidermis: Studies at the air-liquid interface. In: Proceedings of the XXII National Meeting of Italian Connective Tissue Society (SISC), Messina-Lipari (Italy), October 5th-6th, 2001.

7. Maytin EV, Mack JA, Sato N, Anand S, Chung HH. Upregulation of hyaluronan in the epidermis

during cutaneous wound healing in vitro and in vivo. In: Balazs E, Hascall V, editors. Proceedings of Hyaluronan 2003, An international conference, Cleveland, Ohio Oct 11-16, 2003. 15 pages. Matrix Biology Institute. Published in 2004 online at: http://www.matrixbiologyinstitute.org/ha03/toc.htm

8. Mack JA, Abramson SR, Coffin JC, Rothrock JK, Largman C, Hascall VC, Maytin EV. Skin from

adult Hoxb13 knockout (KO) mice exhibits high levels of hyaluronan and enhanced wound healing. In: Hyaluronan: Structure, Metabolism, Biological Activities, Therapeutic Applications. Balazs, E and Hascall, VC, eds. Matrix Biology Institute, Edgewater, NJ. pages 791-198, 2005.

9. Maytin EV, Mack JA, Sato N, Anand S, Chung HH. Upregulation of hyaluronan in the epidermis

during cutaneous wound healing in vivo and in vitro. In: Hyaluronan: Structure, Metabolism, Biological Activities, Therapeutic Applications. Balazs, E and Hascall, VC, eds. Matrix Biology Institute, Edgewater, NJ. pages 597- 610, 2005.

10. Maytin EV, Anand S, Sato N, Mack J, Ortel B. Harnessing cellular differentiation to improve

ALA-based photodynamic therapy in an artificial skin model. In: Optical Methods for Tumor Treatment and Detection: Mechanisms an Techniques in Photodynamic Theray XIV, edited by David Kessel, Proceedings of SPIE, Vol. 5689, pp, 318-329 (International Society of Optical Engineering, Bellingham, WA) 2005.

11. Maytin EV, Anand S, Sato N, Mack J, Gasbarre C, Keevey S, Ortel B, Sinha AK , Khachemoune

A. Nuclear transcription factors: A new approach to enhancing cellular responses to ALA-mediated photodynamic therapy. In: Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV, edited by David Kessel, Proc. SPIE, Vol. 6139. pp. 1-10. (International Society of Optical Engineering, Bellingham, WA) 2006.

12. Maytin EV, Anand S, Baran C, Honari G, Lohser S, Kyei A, Bailin P, Pogue BW. Enhancement

and optimization of PpIX-based photodynamic therapy of skin cancer: Translational studies from bench to clinic. In: Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVIII, edited by David Kessel, Proc. of SPIE (Intl Soc Optical Engineer). Vol. 7164, pp. 71640K1-9, 2009.

13. Anand S, Honari G, Paliwal A, Hasan T, Maytin EV. Enhancement of tumor responsiveness to

aminolevulinate-photodynamic therapy (ALA-PDT) using differentiation-promoting agents in mouse models of skin carcinoma. In: Photodynamic Therapy: Back to the Future, edited by David H. Kessel. Proc. of SPIE (Intl Soc Optical Engineer). Vol. 7380, pp. 73804B1-7, 2009.

14. Warren CB, Lohser S, Chang S, Bailin PA, Maytin EV. In-vivo fluorescence dosimetry of

aminolevulinate-based protoporphyrin IX (PpIX) accumulation in human nonmelanoma skin cancers and precancers. In: Photodynamic Therapy: Back to the Future, edited by David H. Kessel. Proc. of SPIE (Intl Soc Optical Engineers). Vol. 7380, pp. 73801 M1-9, 2009.

15. Ebner JA, Maytin EV. Cutaneous wound healing. In: Dermatologic Surgery. Vidimos AT,

Ammirati CT, and Poblete-Lopez C, editors. From textbook series, Requisites in Dermatology, Elson DM, editor. Publisher: Saunders/Elsevier, New York, 2009, pages 81-100.


16. Gasbarre CC, Maytin EV. Photodynamic Therapy. In: Dermatologic Surgery. Vidimos AT,

Ammirati CT, and Poblete-Lopez C, editors. From textbook series, Requisites in Dermatology, Elson DM, editor. Publisher: Saunders/Elsevier, New York, 2009, pages 245-253.

17. Maytin EV, Anand S, Atanaskova N, Wilson C. Vitamin D as a potential enhancer of

aminolevulinate-based photodynamic therapy for nonmelanoma skin cancer. In: Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIX, edited by David Kessel, Proc. of SPIE, Vol. 7551, 755105 K1-9, 2010. ([DOI]:10.1117/12.847183).

18. Maytin EV, Anand S, Wilson C, Iyer K. 5-Fluorouracil as an enhancer of aminolevulinate-based

photodynamic therapy for skin cancer: New use for a venerable agent? In: Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XX, edited by David Kessel, Tayyaba Hasan. Proc. of SPIE, Vol. 7886, 78860K1-8 (2011); doi:10.1117/12.874188.

19. Paliwal A, Torosean S, Gruber J, O'Hara J, Hasan T, Pogue B, Maytin EV. In vivo validation of

high frequency ultrasound-guided fluorescence tomography system to improve delivery of photodynamic therapy, In: Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XX, edited by David Kessel, Tayyaba Hasan. Proc. of SPIE 7886, 788610 (2011); doi:10.1117/12.875629.

20. Anand S, Hasan T, Maytin EV. Mechanism of enhanced responses after combination

photodynamic therapy (cPDT) in carcinoma cells involves C/EBP-mediated transcriptional upregulation of the coproporphyrinogen oxidase (CPO) gene. In: Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII, edited by David Kessel, Tayyaba Hasan. Proc. SPIE. 8568, 856807 (March 13, 2013) doi: 10.1117/12.2004488.

21. Flynn BP, D'Souza AV, Kanick SC, Maytin EV, Hasan T, Pogue BW. Subsurface PpIX imaging

in vivo with ultrasound-guided tomographic spectroscopy: reconstruction vs. born-normalized data. In: Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII. Proc. SPIE. 8568, 856809 (March 13, 2013) doi: 10.1117/12.2007502.

22. Maytin EV, Lohser S, Tellez A, Wene L, Ishak R, Anand S. Clinical studies of combined

photodynamic therapy using 5-fluorouracil and methylaminolevulinate in patients at high risk for squamous cell carcinoma. In: Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII. Proc. SPIE. 8568, 85680N (March 13, 2013) doi: 10.1117/12.2001882.

23. Rollakanti K, Anand S, Maytin EV. In-vivo luminescence model for the study of tumor regression

and regrowth following combination regimens with differentiation-promoting agents and photodynamic therapy. In: Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII. Proc. SPIE. 8568, 85680Y (March 13, 2013) doi: 10.1117/12.2004637.

24. D'Souza AV, Flynn BP, Kanick SC, Torosean S, Davis SC, Maytin EV, Hasan T, Pogue BW. An

ultrasound-guided fluorescence tomography system: design and specification. Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII. Proc. SPIE. 8568, 85681A (March 13, 2013) doi: 10.1117/12.2007504.


29. Rollakanti, K. R., S. Anand and E. V. Maytin (2015) Topical calcitriol prior to photodynamic

therapy enhances treatment efficacy in non-melanoma skin cancer mouse models. Proceedings of SPIE Vol. 9308, pp. 93080Q93081-93088.

30. Maytin, E. V., S. Anand and K. R. Rollakanti (2015) Clinical potential for vitamin D as a

neoadjuvant for photodynamic therapy of nonmelanoma skin cancer. Proceedings of the SPIE Vol. 9308, pp. 93080H93081-93087.

INVITED REVIEWS: 1. Maytin EV. Basic life sciences, vol 53, DNA damage and repair in human tissues Arch

Dermatol 1991; 127:1089-1090. [book review]. 2. Maytin EV. Clinical Photomedicine J Am Acad Dermatol 1994; 31:143. [book review]. 3. Maytin EV. Heat shock proteins and molecular chaperones: implications for adaptive responses

in the skin. J Invest Dermatol 1995; 104: 448-455. [invited review] 4. Romero RA and Maytin EV. Keratins and their role in epidermal diseases. Dermatol Cosmet

(Llorca MA, ed., Madrid) 1997; VII: 207-213. [invited review] 5. Mack JA, Anand S. Maytin EV. Proliferation and cornification during development of the

mammalian epidermis. Birth Defects Research (Part C) 75: 314-329, 2005. [invited review] 6. Akilov OE, Kosaka S, Maytin EV, Hasan T. Prospects for the use of differentiation-modulating

agents as adjuvant of photodynamic therapy for proliferative dermatoses. J Dermatol 35:197-205, 2008. [invited review]

7. Warren CB, Karai LJ, Vidimos A, Maytin EV. Pain associated with aminolevulinic acid-

photodynamic therapy of skin disease. J Am Acad Dermatol 61 (6): 1033-1043, 2009. [peer-reviewed literature summary]

8. Anand S, Ortel BJ, Pereira SP, Hasan T, Maytin EV. Biomodulatory Approaches to

Photodynamic Therapy of Solid Tumors, Cancer Letters, Dec 29;326(1):8-16, 2012. [invited review] 2012, 326(1):8-16.

9. Rollakanti K, Kanick SC, Davis SC, Pogue BW, Maytin EV. Techniques for fluorescence

detection of protoporphyrin IX in skin cancers associated with photodynamic therapy. Photon Lasers Med (2013), in press.

10. Ghatak S, Maarkwald RR, Hascal VC, Maytin EV, Mack JA, Atanelishvili I, Moreno-Rodriguez

RA, Misra S. Roles of proteoglycans and glycosaminoglycans in wound healing and fibrosis, Int J Cell Biol. 2015;2015:834893. doi: 10.1155/2015/834893. Epub 2015 Sep 10.

11. Shakya S, Wang Y, Mack JA, Maytin EV. Hyperglycemia-induced changes in hyaluronan

contribute to impaired skin wound healing in diabetes”, Int. J Cell Biol, 2015: 701738. doi: 10.1155/2015/701738. Epub 2015 Sep 10.

ABSTRACTS (since 2000):


1. Maytin EV, Ubeda M, Lin JC, Habener JF. Induction of apoptosis by CHOP/gadd153, a transcription factor involved in carcinogenesis and adaptation to stress. J Invest Dermatol 2000; 114: 763.

2. Passi A, Sadeghi P, Maytin EV. Hyaluronan production by epidermal keratinocytes:

Upregulation during differentiation of rat keratinoctes in an artificial epidermis at the air-liquid interface.

J Invest Dermatol 2001; 117: 410. 3. Sadeghi P, Passi A, Kawamura H, Maytin EV. An in vitro epidermal lift culture model using

BALB/MK mouse keratinoctes cultured on MDCK cell-derived basement membranes and other substrates. J Invest Dermatol 2001; 117: 421.

4. Passi A., Sadeghi P, Kawamura H, Hascall V, Maytin EV. Hyaluronan production is upregulated

during keratinocyte differentiation in an organotypic model of the epidermis: Studies at the air-liquid interface. Italian Biochem. Soc. Transactions (IBST) 2001; 17; 104.

5. Ortel B, Sharlin D, O'Donnell D, Maytin E, Hasan T. Short-term differentiation therapy and PDT.

Abstract presented in July 2001 at American Society of Photobiology, Chicago, IL 6. Maytin EV, Passi A, White LE, Kawamura H, Sadeghi P, Hascall VC. Hyaluronan in the

extracellular space modulates keratinocyte differentiation in an epidermal lift culture model. J Invest Dermatol 2002; 119: 261.

7. Maytin EV, Passi A, White LE, Kawamura H, Sadeghi P, Hascall VC. Extracellular hyaluronan

modulates cellular differentiation in rat keratinocyte lift cultures. Abstract presented in Sept. 2002 at 2nd International Symposium on Science and Technology of

Skin Aging, sponsored by L'Oreal Research & Case Western Reserve University, Cleveland, OH.

8. Mack JA, Abramson SR, Ben Y, Coffin JC, Rothrock JK, Maytin EV, Hascall VC, Largman C,

Stelnicki EJ. Hoxb13 knockout adult skin displays fetal-like characteristics and enhanced wound healing. J Invest Dermatol 2003; 121: 471.

9. Pasonen-Seppanen S, Tammi M, MacCallum D, Maytin E, Hascall V, Tammi R. Retinoic acid

up-regulates hyaluronan production but retards keratinocyte differentiation. J Invest Dermatol 2003; 121: 518

10. Chakrabarti E, Kawamura H, Maytin EV. CHOP/gadd153 expression, caspase-3 activation, and

sunburn cell formation (apoptosis) are upregulated concurrently following UVB irradiation of murine skin. J Invest Dermatol 2003; 121: 1125.

11. Ortel B, Sinha AK, Sharlin D, Hasan T, Maytin EV. Order-dependent enhancement of ALA-PDT

by chemotherapy in prostate cancer cells. Proc Amer Assoc Cancer Res 2003; 44: 852. 12. Fein H, Maytin EV, Bailin PL. Histologic and clinical effects of topical protease application: A

novel method of epidermal ablation. Poster at the American Academy of Dermatology annual meeting, Washington, DC Feb 6-11, 2004.

13. Woodhouse J, Maytin EV. Eruptive nevi of the palms and soles. Oral presentation in the Gross

and Microscopic Symposium (Dr. Woodhouse) at the American Academy of Dermatology annual meeting, Washington, DC Feb 6-11, 2004.


14. Sato N, Mack JA, Maytin EV. Wounding-induced up-regulation of hyaluronan in organotypic cultures of keratinocytes. J Invest Dermatol 2004; 122, A73.

15. Mack JA, Li L, Sato N, Hascall VC, Maytin EV. Overexpresson of Hoxb13 in an epidermal

organotypic system disrupts hyaluronan distribution and results in a psoriasiform phenotype. J Invest Dermatol 2004; 122, A73.

16. Anand S, Ortel BJ, Hasan T, Maytin EV. Regulation of the coproporphyrinogen oxidase gene

promoter by C/EBP transcription factors: insights into enhanced ALA-photodynamic therapy. J Invest Dermatol 2004; 122, A85. 17. Anand S, Ortel BJ, Sinha AK, Hasan T, Maytin EV. Methotrexate enhances ALA-mediated

photodynamic therapy in prostate cancer cells. Proc Amer Assoc Cancer Res 2004 (Mar); 45: 2011.

18. Anand S, Taylor CR, Maytin EV. The transcription factor CHOP/gadd153 is expressed during

UVB-induced ER stress in murine and human epidermis. J Invest Dermatol 2005; 124; A23. 19. Sato N, Anand S, Ortel B, Maytin EV. Vitamin D enhances cellular differentiation and

protoporphyrin IX accumulation in rat organotypic keratinocyte cultures treated with aminolevulinic acid: implications for photodynamic therapy. J Invest Dermatol 2005; 124; A64.

20. Mack JA, Sato N, Li L, Hascall VC, Maytin EV. Overexpression of Hoxb13 in a rat epidermal

keratinocyte organotypic system results in upregulation of transglutaminase activity. J Invest Dermatol 2005; 124; A65.

21. Anand S, Sato N, Moore B, Hasan T, Maytin EV. Transcriptional modulation of

coproporphyrinogen oxidase by CCAAT enhancer binding proteins (C/EBPs) and their isoforms: A possible mechanism for enhanced ALA-photodynamic therapy. Proc Am Assoc Cancer Res 2006; 47:4620.

22. Anand S, Sato N, Hasan T, Maytin EV. Differentiation-induced expresssion of specific C/EBP

isoforms in skin and prostate epithelial cells. J Invest Dermatol 2006; 126(4); A68. 23. Mack JA, Monslow, Maytin EV. The Hoxb13 transcription factor represses hyaluronan synthase

2 (HAS2) promoter activity. J Invest Dermatol 2006; 126 (4); A63. 24. Ajani G, Sato N, Mack JA, Maytin EV. A bioengineered model of epidermal barrier injury:

acetone treatment leads to hyperplasia and differentiation in REK organotypic cultures. J Invest Dermatol 2006; 126 (4); A70.

25. Pasonen-Seppanen, Maytin EV, Torronen K, Hyttinen J, Kultti A, Tammi M, Tammi R. All-trans

retinoic acid induced hyaluronana production and hyperplasia are mediated by EGFR-ERK signaling in epidermal keratinocytes. J Invest Dermatol 2006; 126 (4); A87.

26. Gasbarre C, Khachemoune A, Sato N, Moore B, Keevey S, Hasan T, Maytin EV. Vitamin D and

its analogs modulate photosensitizer production in 5-aminolevulinic acid (ALA) treated psoriasis plaques and epidermal organotypic cultures. J Invest Dermatol 2006; 126 (4); A141.

27. Mack JA, Sato N, Anand S, Keevey S, Maytin EV. The use of rat epidermal keratinocytes

(REKs) in an organotypic model of epithelial injury. Wound Repair and Regeneration 2006; 14: A72.


28. Ajani G, Sato N, Mack J, Maytin EV. Acetone-induced barrier injury leads to increased levels of hyaluronan in 3-D keratinocyte cultures. Presentation at the International Conference on Hyaluronan 2007, International Society of Hyaluronan Sciences. April 22-27, 2007 Charleston, SC B. Toole and VC Hascall, conference organizers.

29. Mack JA, Monslow J, Anand S, Maytin EV. The hoxb13 transcription factor regulates hyaluronan synthase 2 expression. Presentation at the International Conference on Hyaluronan 2007, International Society of Hyaluronan Sciences. April 22-27, 2007 Charleston, SC B. Toole and VC Hascall, conference organizers.

30. Maytin EV, Mack JA, Sato N, Monslow J, Ajani G. Hyaluronan is induced by wounding and by

superficial barrier injury in an organotypic skin model. Presentation at the International Conference on Hyaluronan 2007, International Society of Hyaluronan Sciences. April 22-27, 2007 Charleston, SC B. Toole and VC Hascall, conference organizers.

31. Monslow J, Sato N, Hascall VC, Maytin EV. Induction of hyaluronan synthesis in a 3-D

organotypic skin model after wounding. Presentation at the International Conference on Hyaluronan 2007, International Society of Hyaluronan Sciences. April 22-27, 2007 Charleston, SC B. Toole and VC Hascall, conference organizers.

32. Ebner JA, Anand S, Keevey S, Gasbarre C, Maytin E. Characterization of C/EBP transcription

factor isoforms in non-melanoma skin cancer. J Invest Dermatol 2007; 127 (Suppl 1); S27. 33. Anand S, Mack JA, Hasan T, Maytin EV. Methotrexate enhances protoporphyrin IX

accumulation in skin carcinoma cell lines and organotypic epithelial cultures: Implications for enhanced photodynamic therapy. J Invest Dermatol 2007; 127 (Suppl 1); S49.

34. Mack JA, Maytin E. Altered Hoxb13 expression differentially influences the inflammatory

response following cutaneous injury. J Invest Dermatol 2008; 128 (Suppl 1); S23. 35. Anand S, Honari G, Hasan T, Maytin EV. Modulation of tumor responsiveness to photodynamic

therapy using differentiation-promoting agents in a mouse model of skin cancer. J Invest Dermatol 2008; 128 (Suppl 1); S77.

36. Mack JA, Maytin EV. Overexpression of Hoxb13 in mouse skin results in delayed wound

healing, dermatitis, and upregulation of VEGF. J Invest Dermatol 2009; 129 (Suppl 1); S6. 37. Anand S, Paliwal A, Maytin EV. Reduced skin tumor formation in CHOP/GADD153 deficient

mice exposed to chemical carcinogens. J Invest Dermatol 2009; 129 (Suppl 1); S31. 38. Monslow J, Ajani G, Maytin EV. Barrier injury to the stratum corneum by acetone causes a

marked increase in hyaluronan that is medicated via the EGF receptor pathway in a 3-D epidermal keratinocyte model. J Invest Dermatol 2009; 129 (Suppl 1); S72.

39. Feldman R, Monslow J, Itano N, Kimata K, Maytin EV. Upregulation of hyaluronan synthases

during phorbol ester (TPA)-induced hyperplasia with potential functional compensation by Has2 in Has1/Has2 double knockout mice. J Invest Dermatol 2009; 129 (Suppl 1); S75.

40 Mack JA, Maytin EV. Overexpression of Hoxb13 in the basal layer of the epidermis results in

upregulation of TGF-beta activity and an enhanced fibrotic response in cutaneous wounds. J Invest Dermatol 2010; 130 (Suppl 1); S4.


41. Paliwal A, Gruber JD, O'Hara JA, Pogue BW, Hasan T, Maytin EV. Development and validation of a high frequency ultrasound-guided fluororescence tomography system to improve targeting of photodynamic therapy of skin tumors. J Invest Dermatol 2010; 130 (Suppl 1); S131.

42. Anand S, Atanaskova N, Wilson C, Hasan T, Maytin EV. Enhancement of protophorphyrinIX

and suppression of ferrochelatase levels by Vitamin D in tumor models of nonmelnoma skin cancer: Implications for tumor response to photodynamic therapy. J Invest Dermatol 2010; 130 (Suppl 1); S137.

43. Anand S, Hasan T, Maytin E. Vitamin D pretreatment augments aminolevulinate photodynamic

therapy-induced cell death by upregulation of tumor necrosis factor alpha and caspase-8 in mouse models of skin carcinoma. Photodiagnosis and Photodynamic Therapy, 8(2): 129 June 2011, doi: 10.1016/j.pdpdt.2011.03.026

44. Maytin E, Anand S, Ortel B, Hasan T. Combination therapy using methotrexate, 5-fluorouracil,

and vitamin D as PpIX-elevating agents followed by ALA-PDT of skin tumors: Mechanisms of action. Photodiagnosis and Photodynamic Therapy, 8(2): 129 June 2011, doi: 10.1016/j.pdpdt.2011.03.027

45. Mack J, Stubbs H, Maytin EV. Cutaneous wounds in mice lacking functional hyaluronan

synthases Has1 and Has3 display phenotypic features associated with tissue fibrosis. J Invest Dermatol 2012; 132: S138.

46. Anand S, Brankov N, Rollakanti K, Hasan T, Maytin EV. The combination of 5-fluorouracil and

aminolevulinate-photodynamic therapy enhances tumor cell death by targeting p53-MDM2 pathway in murine squamous cell carcinoma tumors. J Invest Dermatol 2012; 132: S120.

47. Maytin EV, Anand S, Brankov N, Rollakanti K, Iyer KActivation of p53-mediated apoptosis in

squamous cell carcinoma tumors in vivo, during combination treatment with 5-fluorouracil and ALA-photodynamic therapy. Oral presentation at Annual SPIE meeting, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XX (David Kessel, director). San Francisco, CA Jan. 21-22, 2012.

48. Mack J, Stubbs H, Maytin EV. Loss of functional hyaluronan synthases Has1 and Has3 in mice

leads to inflammation and fibrosis during wound healing. Presentation at Fibrosis: Translation of Basic Research to Human Disease and Novel Therapeutics. Keystone Symposium on Molecular and Cellular Biology, Big Sky Resort, Big Sky, Montana. Mar 30 - April 4, 2012. Paul Noble et al., Conference organizers.

49. Maytin, EV. Use of Vitamin D and other small molecules to enhance PDT outcome.

Presentation at 36th Meeting of American Society of Photobiology, Montreal, Canada. June 23-27, 2012.

50. Anand S, Rollakanti K, Brankov N, Maytin EV. Enhanced tumor development in

CHOP/gadd153 knockout mice after UVB exposure involves p53 mutation and down regulation of p21 and MDM2. 36th Meeting of American Society of Photobiology, Montreal, Canada. June 23-27, 2012.

51. Anand S, Rollakanti KR, Brankov N, Maytin EV. UVB-induced p53 mutations are associated

with enhanced tumor formation in CHOP/gadd153 knockout mouse skin. J Invest Dermatol 2013; 133: S218.


52. Mack JA, Maytin EV. K14-directed Hoxb13 transgenic mice develop phorbol-induced and age-related hyperproliferative skin lesions characterized by enhanced inflammation and angiogenesis. J Invest Dermatol 2013; 133: S42.

53. Maytin EV, Anand S, Rollakanti KR. 5-Fluorouracil preconditioning followed by photodynamic

therapy enhances apoptotic responses in squamous cell carcinoma through increased levels of p53. J Invest Dermatol 2013; 133: S175.

54. Wang Y, Mack JA, Maytin EV. Enhanced pericellular hyaluronan (HA) coat formation and

resistance to apoptosis in Has1/Has3 double-null fibroblasts from the skin. Presentation at the International Conference on Hyaluronan 2013, International Society of Hyaluronan Sciences. June 2-7,2013 Oklahoma City, Paul Weigel et al., conference organizers.

55. Maytin EV, Wang Y, Mack JA. Hyaluronan and cutaneous wound healing: Paracrine factors

from keratinocytes regulate the pericellular HA coat on cutaneous murine fibroblasts. Presentation at the International Conference on Hyaluronan 2013, International Society of Hyaluronan Sciences. June 2-7, 2013 Oklahoma City, Paul Weigel et al., conference organizers.

56. Maytin EV, Basic principles for application of PDT in high risk skin cancer populations. In:

Forum F075: Photodynamic Therapy in Difficult and High-Risk Patient Populations. Amer Acad Dermatology Annual Meeting. March 22, 2014, Denver CO, Edward Maytin, session organizer.

57. Maytin EV, Enhancing PDT efficacy through pharmacological methods. In: Forum S052:

Photodynamic Therapy. Amer Acad Dermatology Annual Meeting. March 25, 2014, Denver CO, Rolf-Markus Szeimies, session organizer.

58. Maytin EV, Improving tumor responses to photodynamic therapy by pretreatment with small

molecule enhancers of cellular differentiation. Amer Society Photobiology, June 14-17, 2014, San Diego CA, Beth Gaillard, conference organizer.

59. Anand S, Rollakanti KR, Hasan T, Maytin EV, Combination of Oral Vitamin D3 with

Photodynamic Therapy Enhances Tumor Cell Death in a Murine Model of Cutaneous Squamous Cell Carcinoma. Amer Society Photobiology, June 14-17, 2014, San Diego CA, Beth Gaillard, conference organizer.

60. Rollakanti KR, Anand S, Maytin EV, Vitamin D Pretreatment Enhances the Effect of

Aminolevulinate Based Photodynamic Therapy for Basal Cell Carcinoma. Amer Society Photobiology, June 14-17, 2014, San Diego CA, Beth Gaillard, conference organizer.

61. Maytin EV, Biopharmaceutical manipulation to improve clinical responsiveness of human skin

cancers to aminolevulinate-based photodynamic therapy. Presentation at the International Congress of Porphyrins and Pthalocyanines (ICPP8). June 22-27,2014, Istanbul, Turkey, Kristian Berg and Vefa Ahsen, conference organizers.

62. Mack JA, Shakya S, Maytin EV. Skin wounds in mice lacking hyaluronan synthases 1 and 3 show increased TFG-β1 and Has2 expression and evidence of myofibroblast dysregulation. Annual meeting of Am Soc Matrix Biol, Marriott Key Center, Cleveland Ohio, October 12-15, 2014.

63. Wang Y, Lauer M, Anand S, Mack JA, Maytin EV. Hyaluronan synthase 2 (Has2) protects skin

fibroblasts against apoptois induced environmental stress. Annual meeting of Am Soc Matrix Biol, Marriott Key Center, Cleveland Ohio, October 12-15, 2014.


64. Rollakanti K, Anand S, Maytin EV. Topical Calcitriol Treatment Prior to Photodynamic

Therapy Enhances Efficacy in Nonmelanoma Skin Cancer Mouse Models, oral presentation at Annual SPIE meeting, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIV (David Kessel, director). San Francisco, CA February 8, 2015.

65. Maytin EV, Anand S, Rollakanti K, Clinical Potential for Vitamin D as a Neoadjuvant for Photodynamic Therapy of Nonmelanoma Skin Cancer, oral presentation at Annual SPIE meeting, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIV (David Kessel, director). San Francisco, CA February 8, 2015.

66. Shakya S, Mack J, Maytin EV. Expression of hyaluronan and HAS enzymes in primiary and

immortalized dermal microvascular endothelial cells. Annual conference of Program of Excellence in Glycosciences, National Institutes of Health, Bethesda MD, April 15-16, 2015.

67. Wang Y, Anand S, Mack J, Maytin EV. UVB-induced apoptosis in cells from the skin of mice

lacking HAS1 and HAS2: Opposite effects in keratinocytes versus fibroblasts. Annual conference of Program of Excellence in Glycosciences, National Institutes of Health, Bethesda MD, April 15-16, 2015.

68. Maytin EV, Riha M, Vidioms A. Clinical study of a painless PDT protocol for actinic keratoses of

the face and scalp. Annual meeting of the ASLMS (Amer Soc Lasers in Medicine and Surgery), Orlando, FL April 24-25, 2015.

69. Maytin EV, Mack J, Wang Y, Shakya S. HA regulation of inflammation and fibrosis in skin

wounds. 10th International Conference on Hyaluronan, International Society of HA Sciences (ISHAS), Hilton Florence Metropole Hotel, Florence, Italy, June 7-11, 2015.

70. Mack J, Wang Y, Shakya S, Maytin EV. HAS1/3 knockout mice show increased expression of

TGF-b1 and hyaluronan synthase 2, and enhanced myofibroblast activity in skin wounds. 10th International Conference on Hyaluronan, International Society of HA Sciences (ISHAS), Hilton Florence Metropole Hotel, Florence, Italy, June 7-11, 2015.

71. Wang Y, Anand S, Lauer M, Mack J, Maytin EV. UVB-induced Apoptosis in Cells from the Skin

of Mice Lacking Has1 and Has3: opposite Effects in Keratinocytes versus Fibroblasts. 10th International Conference on Hyaluronan, International Society of HA Sciences (ISHAS), Hilton Florence Metropole Hotel, Florence, Italy, June 7-11, 2015.

INVITED ORAL PRESENTATIONS BY STUDENTS/FELLOWS AT NATIONAL/INTERNATIIONAL MEETINGS: Invited talk by Sanjay Anand, Ph.D. Title: Cellular differentiation to enhance photodynamic therapy of cancer; at XXIXth All-India Cell Biology Conference. Banaras Hindu University, Varansi, India, December 14-16, 2007. Invited talk by Sanjay Anand, Ph.D. Title: Modulation of tumor responsiveness to photodynamic therapy using differentiation-promoting agents in a mouse model of skin cancer; at International Investigative Society Meeting, Kyoto, Japan, May 14-17, 2008.


Invited talk by Akshat Paliwal, B.S.) at Research in Cutaneous Surgery Minisymposium, Annual Meeting of the Society of Investigative Dermatology, Atlanta, GA, May 2010. Invited talk by Sanjay Anand, Ph.D. Title: Vitamin D pretreatment augments aminolevulinate photodynamic therapy-induced cell death by upregulation of tumor necrosis factor alpha and caspase-8 in mouse models of skin carcinoma; at 13th IPA World Congress, International Photodynamic Association, Innsbruck, Austria, May 10-14, 2011. Invited talk by Sanjay Anand, Ph.D. Title: Chemical versus UVB carcinogenesis regimens yield opposing tumor responses in skin of Chop/gadd153 null mice.at Congress of the European Society of Photobiology/American Society of Photobiology (combined symposium on PDT), University of Geneva, Geneva, Switzerland, 2-6 September 2011. Invited talk by Sanjay Anand, Ph.D. Title: Enhanced tumor cell death by combination of 5-fluorouracil with aminolevulinate-based photodynamic therapy involves the p53-MDM2 pathway in murine tumors. 36th Meeting of American Society of Photobiology, Montreal, Canada. June 23-27, 2012. Invited talk by Sanjay Anand, Ph.D. Title: Enhanced tumor development in CHOP/gadd153 knockout mice after UVB exposure involves p53 mutation and down regulation of p21 and MDM2. 36th Meeting of American Society of Photobiology, Montreal, Canada. June 23-27, 2012. Invited talk by Kishore Rollakanti, B.Pharm. Title: In-vivo luminescence model for the study of tumor regression and regrowth following combination regimens with differentiation-promoting agents and photodynamic therapy. Conference: "Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII”, at SPIE meeting, San Francisco, CA. February 1-3, 2013. Invited talk by Kishore Rollakanti, B.Pharm. Title: Vitamin D Pretreatment Enhances the Effect of Aminolevulinate Based Photodynamic Therapy for Basal Cell Carcinoma. American Society of Photobiology, San Diego CA, June 14-17, 2014. Invited talk by Kishore Rollakanti, B.Pharm. Title: Topical calcitriol treatment prior to photodynamic therapy enhances efficacy in nomelanoma skin cancer mouse models. Conference: "Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIV”, SPIE mtg, San Francisco, CA. Feb 7-9, 2015.

INVENTIONS/PATENTS: T. Hasan, B. Ortel, E. Maytin Integrated Photodynamic and Differentiation Therapy US Patent No. 09/586,235. 6/2/2000 (CV in Lerner Research Institute format, prepared Jan 2016)

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CURRICULUM VITAE Edward V. Maytin, M.D. Ph.D. CITIZENSHIP: … · 2018-03-24 · CURRICULUM VITAE Edward V. Maytin, M.D. Ph.D. CITIZENSHIP: U.S.A. WORK ADDRESS: Clinical: Desk A61