[ BIOPHARMACEUTICAL SOLUTIONS ]

A new wAy to look At biomolecules

[ BIOPHARMACEUTICAL SOLUTIONS ]

in the race to find cures for the most pressing

medical challenges, biomolecules have shown

a world of promise. However, they have

also proven to be challenging – in terms

of characterizing their structure

and function, and progressing them

into viable biotherapeutics.

see biomolecules from

A better perspective

likewise, with waters, your laboratory will be positioned to pursue only the

most promising compounds and make the most of your time, investment,

and scientific effort. so once your biomolecule has been fully developed,

you’ll have the right information to protect your intellectual property,

achieve regulatory approval, and go to market with a product that

will change lives for the better.

to overcome these challenges and remain competitive in the

biopharmaceutical market, it is critical to work with analytical

technology that is specifically designed for this type of study.

And that means working with waters. world-leading life sciences

organizations are converting to waters’ focused solutions to

capture significant science-driven business improvements.

[ BIOPHARMACEUTICAL SOLUTIONS ]

wAters is As focused As you Are

Focused on your science.

the current state of biopharmaceutical development

requires a different kind of scientific partner. to get

more biotherapeutics to the people who need them,

companies need more customized solutions that

optimize the process of therapeutic development

and manufacturing. other scientific companies may

claim to offer the best specifications. but when it

comes to your biotherapeutic, you need solutions that

are insightfully tailored to fit the requirements of

biopharmaceutical applications. waters has listened to

the needs of investigators and development scientists to

develop appropriate technologies for robust and complete

characterization. we have the market-leading expertise and

proven technology to deliver the right solutions, right now.

Of all LC and LC/MS instrument providers, Waters leads the market with a 25% share –

and we are known for our commitment to life sciences. (Strategic Directions International)

Keep research moving.

waters has decades of experience in supporting the analytical

technology needs of life sciences organizations – from

pharmaceutical drug discovery and development to the

development and formulation of biologics. we know what it takes

to move efficiently through the research and development pipeline –

from basic biochemical measurements like amino acid analysis

and peptide mapping to advanced conformational studies.

we partner with you to understand your goals, so that together we

can determine which solution best meets your needs and business

objectives – and maximizes your return on investment.

“I really enjoy our working relationship to say, what is the problem here, what are the analytical challenges, what are the biological questions we’re trying to answer, and what can be developed to answer those questions.”

Greg Cavey Scientific Investigator Van Andel Institute

built for biopHArmAceuticAls

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Designed with purpose.

unlike other companies whose existing instruments are modified to work for biopharmaceutical

applications, solutions from waters are purpose-built for biopharmaceutical characterization.

we provide integrated uplc®/ms systems, chemistries, and informatics as well as unrivaled

training and support services. you can be assured of a seamless integration between our

solutions and your laboratory workflow.

Waters scientists have published nearly 150 applications and peer-reviewed articles on characterization

techniques using UPLC – a technology that all of the leading life sciences companies are adopting.

“ [Waters is] adding a new dimension to our research… By being able to separate proteins by shape, the SYNAPT® HDMS™ System allows us to distinguish between the various protein forms. The results are really amazing.”

Alison Ashcroft, Ph.D. Professor, Biomolecular Mass Spectrometry and Manager, Mass Spectrometry Facility Astbury Centre for Structural and Molecular Biology University of Leeds

Dedicated to your lab.

partnering with waters adds value immediately,

as well as over the long term. our market-

leading uplc/ms solutions can be quickly

implemented, and are sustainable throughout

your product’s lifetime – enabling you to

expand your laboratory’s capabilities.

in fact, we work with you to ensure methods

and data are transferrable from lab to lab,

around the world, so that all of your sites

are working as one.

As analytical approaches and technology

requirements evolve, we actively collaborate

with you to get the most information out of

your molecule and process. this keeps lag

time to a minimum and gives you greater

control over your entire operation. so you can

maximize both productivity and profitability.

[ BIOPHARMACEUTICAL SOLUTIONS ]

reAcH your

potentiAl

Envision success.

with greater understanding of your biomolecule comes greater potential. waters’ uplc

and ms biopharmaceutical system solutions give you the ultimate in characterization:

enabling you to gather information on the true value of your therapeutic product.

reAcH your

potentiAl

when it comes to regulatory requirements, regulatory bodies

around the world are already looking to waters for the

technology advancements that provide them with more

confidence in your product. And our proven systems for

quality control and monitoring allow you to assure that final

product is within specification – so you can deliver on the

promises you’ve made to your investors – and to the world.

with the characterization knowledge

you gain with waters solutions, you

can ensure that your findings are

protected. you’ll have the indisputable

evidence to prove your work is unique,

repeatable, and your own.

Today, Waters has more than 750 bioseparations-specific and QC-tested analytical and

preparative columns, sample preparation devices, standards, and enabling reagents.

“ACQUITY UPLC® has made a tremendous change in how labs operate in terms of quality of data, speed of data, and how quickly you can generate results from a sample... that’s the key to Waters, providing information in a way that we can use it, in a way that is effective and efficient and accurate. …Waters is a company that provides solutions to us, not just equipment.”

Michael Evans, Ph.D. President and CEO AIT Laboratories

[ BIOPHARMACEUTICAL SOLUTIONS ]

develop your

opportunity

What we do.

n Protein characterization – peptide mapping, intact protein analysis

(size exclusion, ion exchange, and reversed phase chromatography),

intact mass analysis, glycan analysis, and amino acid analysis

n Technologies for a deeper understanding of the biotherapeutic process – peptide

bioanalysis, cell culture analysis, host cell proteins, extractables, and leachables

n Oligonucleotides and synthetic peptides – Analysis of synthetic processes,

including purity and identity

n Vaccines – characterization and quantitation of protein sub-unit vaccines

and excipients

n New technologies for probing the conformational structure of protein therapeutics –

Hydrogen deuterium exchange and ion mobility spectrometry

n Throughout your full product lifecycle – from discovery and characterization

to formulation, stability, and quality control

By 2014, five of the top five best-selling and 50% of the

top 100 branded drugs will be proteins. (Evaluate Pharma)

You see a better tomorrow. We share it.

At waters, it is our responsibility to support both

the scientific community and the global community.

that’s why we share your passion for advancing the

study of biopharmaceuticals. we see a future full of

answers – to challenges such as cancer, infectious

diseases, traumatic injuries, chronic and acute

medical conditions, and inherited disorders.

together, we can bring the promise of the

future into the present.

develop your

opportunity

Tomorrow’s cures can’t wait.

contact waters today to schedule

a consultation with one of

our biopharmaceutical

solutions experts.

“I depend on manufacturers like Waters to take cutting-edge technology that academicians are investigating and formulating and put that into a package that allows me, as a biochemist, to utilize.”

Julie Leary, Ph.D. Professor, Department of Molecular and Cellular Biology University of California-Davis

waters, AcQuity uplc, uplc, and synApt are registered trademarks of waters corporation. the science of what’s possible and Hdms are trademarks of waters corporation. All other trademarks are the property of their respective owners.

©2010 waters corporation. printed in the u.s.A. June 2010 720003480en lb-cp

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