Vision and AimsChalmers AoAs should use our scientific excellences to meet the

global grand challenges where we can make a difference

The AoAs aims to coordinate establishment of excellent cross-disciplinary research. The AoAs contribute to meet societal requirements to integrate research, education and innovation and to establish new arenas between academia, industry and society. Hereby the AoAs contribute actively to reaching Chalmers overall objective to address global challenges in order to establish a sustainable society

The AoAs should together with the departments develop:• Excellent research environments• Integration of research, education and innovation• Research infrastructures• Strategic collaboration with industry• Chalmers brand

FERMENTATION

TECHNOLOGY

MATHEMATICAL

BIOLOGY

FOOD AND

NUTRITIONBIOENGINEERING

SyntheticBiology

Systems Biology

Food Processingand Quality

BioNanoTechnologies

Bioinformatics

Evolution and Population Dynamics

Network Analysis

Enzyme Technology

Biopharmaceuticalsand Nutraceuticals

Biofuels andBiochemicals

Nutritional Biotechnology

Bioavailability

Bioactive Compoundsin Foods

Biomedical Imaging

BiomedicalEngineering

Kinetic Models

BASIC SCIENCE

LIFE SCIENCE ENGINEERING OVERVIEWEXCELLENCE PROFILES

AC

TIV

E F

IEL

DS

Morphogenesis

Biorefineries

Biomaterials

E-health

Bioanalytics andBiomolecular Imaging

PharmaceuticalBiochemistry

MOLECULAR

AND

CHEMICAL

BIOLOGY

Molecular and Chemical Biology (Andrew Ewing)

Mathematical Biology (Torbjörn Lundh)

Fermentation Technology (Lisbeth Olsson)

Food & Nutrition (Ann-Sofie Sandberg)

HumanHealth

Biology Ind.Biotech

Management GroupProfile leaders + 1

young faculty + 1 PhD student + director for

research school + innovation rep. + FCC

rep. + OSS rep.

AoA DirectorJens Nielsen

AoA CoordinatorMartin Markström

Bioengineering (Mikael Persson)

Active Fields

ORGANIZATION

Human Metabolic Atlas

Clinical Data(serum chemistry,

tissue specific data, .)

BiomarkersAnalysis & visualization

Tissue specific models Databases

Circulation model

Metabolic simulations Drug development

External DatabasesExternal Databases

& Clinical Data

Human Metabolic Atlas: The VisionThe Atlas will be an interactive database and modeling infrastructure

that can be used for enriching the value of clinical data

Reconstruction of Cell Type Specific Models

6PLoS Comp. Biol. (2012) 8:e1002518

Human Metabolic AtlasMapping of metabolism in 69 different human cell types

Personalized GEMs for Liver cancerThe presence/absence of enzymes encoded by 2,989 genes present in HMR were evaluated and the proteome data is heterogeneous between the patients.

• Strong•

Moderate

• Weak

• Negative

PATIENT ID SEX AGE LIVER CANCER TYPEPatient 2279 Female 73 CholangioCarcinomaPatient 2399 Female 52 CholangioCarcinomaPatient 3625 Male 59 CholangioCarcinomaPatient 3334 Male 67 CholangioCarcinomaPatient 2556 Male 72 HepatocellularCarcinomaPatient 2766 Female 73 HepatocellularCarcinomaPatient 2177 Female 58 HepatocellularCarcinomaPatient 3196 Male 65 HepatocellularCarcinomaPatient 3477 Male 67 HepatocellularCarcinomaPatient 2280 Male 80 HepatocellularCarcinoma

Pat

ient

217

7

Pat

ient

347

7

Pat

ient

276

6

Pat

ient

319

6

Pat

ient

333

4

Pat

ient

228

0

Pat

ient

362

5

Pat

ient

255

6

Hep

atoc

ytes

Pat

ient

227

9

Pat

ient

239

9

8

Gut metagenomic study in patients with atherosclerosis

9Nature Comm. (2012) 3:1245

Glucose

Sucrose

Galactose

Xylose

Fine chemicals

Biofuels

Commodity chemicals

Protein drugs

Volume

Value

Butanol

Biodiesel

3-HPA

Succinic acid

Sesquiterpenes

Antibiotics

Human insulin

S. cerevisiae

Synthetic Biology

Systems Biology

Bio-Based Production of Fuels & ChemicalsWe are developing yeast cell factories for the production of advanced

biofuels and different chemicals

Nutragenomics and Food ScienceWe are evaluating the role of bioactive food components using a

systems biology

Biomedical EngineeringWe are developing advanced diagnostic tools, e.g. to identify stroke

using microwave analysis