44 158 159 NEUROENDOCRINE DIFFERENTIATION IN NON-SMALL CELL LUNG CANCER (NSCLC)(PHELIMINAHY mum) HellenicCo-operative OncofogyGroup SHeCOG) N.Psaropoup ,D.V.Skarlos 1St.Legak5 ,G.Fou+ilas, T.Kosmidis,N.Martinopoulou ,V.Mitsi,P$vlidis , "Agil Anargiri"? HospitalAthens, "Sismanoglio" HospitalAthens."AZ epa"Hospital,Medical of Universi- $.y of Tbessaloniki ~~Metaxast~Cancer Hospital, Piraeus MedicalSchoolof "Ioannina's University" Greece. 37 histological specimens from non small cell lung cancer (NSCLC)(17 squallous,9.adenocarcinomas, Ilundif ferentiated were stainedwith markersfor neuroendocri ne differentiation (NE)using:neuron specificenolase (NSE),Bombesin (Bomb)Chromo filamenttripletprotein (NFTP $ anine A(Chr-A)neuro- and Leu-7. Results: squamous: NSE:8/17(47%)NFTP: 4117 (23%) Leu-7: 7/17 (41%) Bomb: 12/17 (70%) Chrom: lo/17 (58%) adeno : I&%: 5/9 (55%) NF'P: 319 (44%) Leu-7: 1'1'9(11%) Bomb: 6/9 (66%) Chrom: 4j9'(44%) undiffer: NSE: 2/11 (18%) NFTP: 3/11 (27%) VAXULAR INVASIONIN NON SMALL CELL LUNG CANCER. HASLETONP.S., ROBERTST-E., MIJSGROVE C., SWINDELLR AND LAWSONR.A.M.Wythe~e.;~e&~iospJ~l Eighty seven cases of non small cell lung cancer were examinedretrospectively to comparecertain histological and clinicalfeatures with outcome. All cases had fully documented follow up. The mean follow up time was 92 months. The study confirmed that there is a positive correlation between lymphatic invasion and distant tumour recurrence (p=O.O03). No correlation was seen between the incidence of tumour necrosis or intimal fibrosis in arteries or veins and prognosis. ply contrast there yas no relationship between the presence of vascular invasion and long term survival (p=O.75). These findings suggestthat non small cell carcinoma of the lung behave di'ferently from other commonmalignanttumourssuch as breast,colon and kidney where vascularinvasion is an important prognostic factor. In conclusion NSCLC showesNE differentiation. The study is ongoing.

Vascular invasion in non small cell lung cancer

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Page 1: Vascular invasion in non small cell lung cancer

158 159

NEUROENDOCRINE DIFFERENTIATION IN NON-SMALL CELL LUNG CANCER (NSCLC)(PHELIMINAHY mum)

Hellenic Co-operative Oncofogy Group SHeCOG) N.Psaropoup ,D.V.Skarlos 1St.Legak5 ,G.Fou+ilas, T.Kosmidis ,N.Martinopoulou ,V.Mitsi ,P$vlidis , "Agil Anargiri"? Hospital Athens, "Sismanoglio"

Hospital Athens. "AZ epa"Hospital,Medical of Universi- $.y of Tbessaloniki ~~Metaxast~Cancer Hospital, Piraeus Medical School of "Ioannina's University" Greece. 37 histological specimens from non small cell lung cancer (NSCLC)(17 squallous,9.adenocarcinomas, Ilundif ferentiated were stained with markersfor neuroendocri ne differentiation (NE) using:neuron specific enolase (NSE), Bombesin (Bomb) Chromo filament triplet protein (NFTP $

anine A(Chr-A) neuro- and Leu-7.

Results: squamous: NSE:8/17 (47%) NFTP: 4117 (23%)

Leu-7: 7/17 (41%) Bomb: 12/17 (70%) Chrom: lo/17 (58%)

adeno : I&%: 5/9 (55%) NF'P: 319 (44%) Leu-7: 1'1'9(11%) Bomb: 6/9 (66%) Chrom: 4j9'(44%)

undiffer: NSE: 2/11 (18%) NFTP: 3/11 (27%)

VAXULAR INVASION IN NON SMALL CELL LUNG CANCER. HASLETON P.S., ROBERTS T-E., MIJSGROVE

C., SWINDELL R AND LAWSON R.A.M. Wythe~e.;~e&~iospJ~l Eighty seven cases of non small cell lung cancer were examined retrospectively to compare certain histological and clinical features with outcome. All cases had fully documented follow up. The mean follow up time was 92 months. The study confirmed that there is a positive correlation between lymphatic invasion and distant tumour recurrence (p=O.O03). No correlation was seen between the incidence of tumour necrosis or intimal fibrosis in arteries or veins and prognosis. ply contrast there yas no relationship between the presence of vascular invasion and long term survival (p=O.75). These findings suggest that non small cell carcinoma of the lung behave di'ferently from other common malignant tumours such as breast, colon and kidney where vascular invasion is an important prognostic factor.

In conclusion NSCLC showes NE differentiation. The study is ongoing.