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Red fluorescent dental plaque: An indicator of oral disease?

Volgenant, C.M.C.

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Citation for published version (APA):Volgenant, C. M. C. (2016). Red fluorescent dental plaque: An indicator of oral disease?.

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Download date: 17 Jul 2020

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Financial justification of the research

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Financial justification of the researchThis research was supported by the Dutch Technology Foundation STW, which is part of the Netherlands Organisation for Scientific Research (NWO) and partly funded by the Ministry of Economic Affairs (project number 10948). The users committee of this STW project and STW representative dr. H. van der Valk are kindly acknowledged for their input during the committee meetings: Colgate-Palmolive, represented by dr. C. Timmer; GlaxoSmithKline Consumer Healthcare, represented by dr. R.J. Lynch; Ivoren Kruis (the Dutch national association for preventive oral healthcare), represented by R. Bos; De Friesland Zorgverzekeraar, represented by P. Roozen-Everts and Inspektor Research Systems B.V., represented by E. Waller and dr. ir. E. de Josselin de Jong. Inspektor Research Systems B.V. supported the research in kind by providing a QLF-D camera and software development.

The studies described in chapters 4 and 6 were also supported by the Top Institute Food and Nutrition (TIFN). Purchase of the BioFlux Z1000 setup, used in chapter 4, was (partially) funded by NWO Earth and Life Sciences (ALW), project 834.13.006. The research described in chapter 5 was also supported by NGen Oral Pharma N.V., Willemstad, Curaçao. The research as described in chapter 7 was also supported by Menzis Health Insurer, the Netherlands.

The organizations supporting the research had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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Author contributions

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Author contributionsof the published or submitted manuscripts in this thesis.

Chapter 2 - Effect of metalloporphyrins on red autofluorescence from oral bacteriaC.M.C. Volgenant, M.H. van der Veen, J.J. de Soet, J.M. ten CatePublished in the European Journal of Oral Sciences (2013)Author contributionsConceived and designed the study: CMCV, MHvdV, JJdS, JMtCPerformed the study: CMCV, MHvdVAnalysed the data: CMCV, MHvdVDrafted the manuscript: CMCV, MHvdV, JMtCCritically revised the manuscript: JJdS

Chapter 3 - Red fluorescent biofilm: the thick, the old and the cariogenicC.M.C. Volgenant, M.A. Hoogenkamp, M.J. Buijs, E. Zaura, J.M. ten Cate, M.H. van der VeenPublished in the Journal of Oral Microbiology (2016)Author contributionsConceived and designed the study: CMCV, MAH, JMtC, MHvdVPerformed the study: CMCV, MAH, MHvdV, MJBAnalysed the data: CMCV, EZ, MHvdVDrafted the manuscript: CMCV, MAH, EZ, MHvdVCritically revised the manuscript: MJB, JMtC

Chapter 4 - Red and green fluorescence from oral biofilmsC.M.C. Volgenant, M.A. Hoogenkamp, B.P. Krom, M.M. Janus, J. M. ten Cate, J.J. de Soet, W. Crielaard, M. H. van der VeenSubmittedAuthor contributionsConceived and designed the study: CMCV, MAH, BPK, MHvdV, JJdSPerformed the study: CMCV, MAH, MMJAnalysed the data: CMCV, MAH, MHvdV, JJdSDrafted the manuscript: CMCV, MAH, MHvdV, JJdSCritically revised the manuscript: MMJ, JMtC, BPK, WCThe used saliva samples in this study were obtained as part of a clinical trial (chapter 6). The authors thank N.A.M. Rosema for coordinating the clinical study. For assistance in capturing fluorescence photographs, the authors thank Y. Altindağ. For the clinical examinations the authors thank S. Bizzarro (assessment of the bleeding on marginal probing).

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Chapter 5 - Comparison of red autofluorescing plaque and disclosed plaque – a cross-sectional studyC.M.C. Volgenant, M. Fernandez y Mostajo, N.A.M. Rosema, G.A. Van der Weijden, J.M. ten Cate, M.H. van der VeenPublished in Clinical Oral Investigations (2016)Author contributionsConceived and designed the study: CMCV, MFyM, NAMR, GAvdW, JMtC, MHvdVPerformed the study: CMCV, MFyM, NAMR, MHvdVAnalysed the data: CMCV, MHvdVDrafted the manuscript: CMCV, GAvdW, MHvdVCritically revised the manuscript: MFyM, NAMR, JMtCThe authors thank N. Hennequin-Hoenderdos and D.E. Slot for coordinating the clinical study. For the clinical examinations, the authors thank G. van Anraat (clinical plaque assessment), E.J.C. Martin (assessment of the bleeding on marginal probing), E. van der Sluijs and S. Supranoto (professional prophylaxis).

Chapter 6 - Dynamics of red fluorescent dental plaque during experimental gingivitis – a cohort studyM.H. van der Veen*, C.M.C. Volgenant*, B.J.F Keijser, J.M. ten Cate, W. Crielaard* These authors contributed equally to this manuscriptPublished in the Journal of Dentistry (2016)Author contributionsConceived and designed the study: MHvdV, BJFK, WCPerformed the study: MHvdV, CMCVAnalysed the data: MHvdV, CMCVDrafted the manuscript: MHvdV, CMCVCritically revised the manuscript: BJFK, JMtC, WCThe authors thank N.A.M. Rosema for coordinating the clinical study. For assistance in capturing fluorescence photographs, the authors thank Y. Altindağ. For the clinical examinations the authors thank J.M. Voll (clinical plaque assessment with Silness & Löe), and S. Bizzarro (assessment of the bleeding on marginal probing).

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Chapter 7 - Salivary microbiome composition and red fluorescent dental plaque of children and their parentsC.M.C. Volgenant, B.W. Brandt, M.J. Buijs, D. Duijster, C. van Loveren, J.M. ten Cate, M.H. van der Veen, E. ZauraSubmittedAuthor contributionsConceived and designed the study: CMCV, DD, CvL, MHvdV, EZPerformed the study: CMCV, MJB, DD, MHvdVAnalysed the data: CMCV, BWB, EZDrafted the manuscript: CMCV, BWB, MHvdV, EZCritically revised the manuscript: MJB, DD, CvL, JMtCThe authors would like to acknowledge the support from the Jeugdtandzorg Den Haag, especially Hans Berendsen, Helga Wissenburg and Sylvia Gossen. The authors thank Elly C. van Deutekom - Mulder and Joyce van der Horst for the technical support.

Chapter 8 - Red fluorescence of dental plaque in children – a cross-sectional studyC.M.C. Volgenant, E. Zaura, B.W. Brandt, M.J. Buijs, M. Tellez, G. Malik, A.I. Ismail, J.M. ten Cate, M.H. van der VeenSubmittedAuthor contributionsConceived and designed the study: CMCV, EZ, MT, AII, JMtC, MHvdVPerformed the study: CMCV, MJB, GMAnalysed the data: CMCV, EZ, BWB, MHvdVDrafted the manuscript: CMCV, EZ, BWB, MHvdVCritically revised the manuscript: MJB, MT, GM, AII, JMtCThe authors thank the staff of the pediatric dental clinic at the Kornberg School of Dentistry for their support during the clinical phase of this study and Deborah Krystal Russell, Vani Nanda, Dustin R. Root, Dana Al-Baroudi, Tina M. Statkevicz and Bin Wang for their assistance with the clinical procedures. We thank Prof. dr. R. Stevens and Hongming Zhang from the Kornberg School of Dentistry and Michel A. Hoogenkamp from ACTA for help with storage and transportation of the microbiological samples. The authors also thank Elly C. van Deutekom - Mulder from ACTA for processing the microbiological samples and Ilona F. Persoon from ACTA for assessment of the bitewings.

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List of publications

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List of publications

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List of publicationsPeer reviewed international publicationsVolgenant CMC, Van der Veen MH, De Soet JJ, Ten Cate JM: Effect of metalloporphyrins

on red autofluorescence from oral bacteria. Eur J Oral Sci 2013;121:156-161.Petti S, Kakisina N, Volgenant CMC, Messano GA, Barbato E, Passariello C, De Soet

JJ: Low methicillin-resistant Staphylococcus aureus carriage rate among Italian dental students. Am J Infect Control 2015;43:e89-91.

Volgenant CMC, Fernandez y Mostajo MF, Rosema NAM, Weijden FA, Ten Cate JM, Van der Veen MH: Comparison of red autofluorescing plaque and disclosed plaque – a cross-sectional study. Clin Oral Invest 2016;18:1-8.

Volgenant CMC, Hoogenkamp MA, Buijs MJ, Zaura E, Ten Cate JM, Van der Veen MH: Red fluorescent biofilm: the thick, the old, and the cariogenic. J Oral Microbiol 2016;8:1-9.

Van der Veen MH & Volgenant CMC, Keijser BJF, Ten Cate JM, Crielaard W: Dynamics of red fluorescent dental plaque during experimental gingivitis – a cohort study. J Dent 2016;48:71-76.

Submitted manuscriptsVolgenant CMC, Hoogenkamp MA, Krom BP, Janus MM, Ten Cate JM, De Soet JJ,

Crielaard W, Van der Veen MH: Red and green fluorescence from oral biofilms.Volgenant CMC, Zaura E, Brandt BW, Buijs MJ, Tellez M, Malik G, Ismail AI, Ten

Cate JM, Van der Veen MH: Red fluorescence of dental plaque in children – a cross-sectional study.

Volgenant CMC, Brandt BW, Buijs MJ, Duijster D, Van Loveren C, Ten Cate JM, Van der Veen MH, Zaura E: Salivary microbiome composition and red fluorescent dental plaque of children and their parents.

Imangaliyev SK, Van der Veen MH, Volgenant CMC, Loos BG, Keijser BJF, Crielaard W, Levin E: Application of deep convolutional neural network to dental red fluorescent plaque images.

Janus MM, Crielaard W, Volgenant CMC, Van der Veen MH, Brandt BW, Krom BP: Candida albicans has a community-wide effect on initial in vitro oral biofilms.

Other publicationsWiegman HP, Van Selms MKA, Volgenant CMC, Koopman P, Egmond KJ: ACTA

Overalltoets – Test uw tandheelkundige kennis aan de hand van een klinische casus. Quality Practice, nascholingstijdschrift voor tandartsen 2011;6(4):50-51.

Schoonheim-Klein ME, Van Selms MKA, Volgenant CMC, Wiegman HP, Vervoorn JM: Het beoordelen van de klinische competenties van studenten tandheelkunde. Nederlands Tijdschrift voor Tandheelkunde 2012;119:328-336.

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List of publications

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De Soet JJ, Laheij AMGA, Volgenant CMC: Ontwikkeling van de richtlijn infectiepreventie in mondzorgpraktijken. Quality Practice, nascholingstijdschrift voor mondhygiënisten 2015;7(3):15-20 & nascholingstijdschrift voor tandartsen 2015;10(6):15-20.

Imangaliyev SK, Van der Veen MH, Volgenant CMC, Keijser BJF, Crielaard W, Levin E: Deep learning for classification of dental plaque images. The 2nd International Workshop on Machine learning, Optimization and big Data (MOD), Volterra, 2016.

(Co-)author of abstracts at scientific conferencesORCA 2011, Kaunas, LithuaniaRed fluorescence of dental plaque from dental students.

IADR 2012, Iguazu, BrazilMedium additives determine the autofluorescence of in vitro biofilm;Visual comparison of red fluorescing plaque and disclosed plaque on photos.

ORCA 2012, Cabo Frio, BrazilBiofilm age and thickness determines the amount of red fluorescence;Visual detection of caries lesions on oral white light and fluorescence photographs.

ORCA 2013, Liverpool, United KingdomCaries assessment of occlusal surfaces on QLF- and white light photographs.

KNVM-NVMM conference, Papendal, the NetherlandsMethicillin resistant Staphylococcus aureus in dental students.

ORCA 2015, Brussels, BelgiumRed fluorescence of dental plaque in relation to the caries status in children.

OMIG 2016, Gregynog Hall, Wales, United KingdomRed fluorescence from in vivo and in vitro oral biofilm – the effect of different donors.

ORCA 2016, Athens, GreeceDental caries status of institutionalized young adults with mild mental disability and multi-problems – first results;The motivational effect of fluorescence photographs additional to oral hygiene lessons at primary schools.

Red fluorescent dental plaqueAn indicator of oral disease?

C.M.C. Volgenant

Red fluorescent dental plaque C

.M.C

. Volgenant

Invitationto attend the public defense

of the PhD thesis

Red fluorescent dental plaque

An indicator of oral disease?

by Catherine Volgenant

on Friday, September 30, 2016 at 13:00 hrs, Aula of the

University of Amsterdam, Oude Lutherse Kerk,

Singel 411, Amsterdam.

You are cordially invited to the reception after the defense at

Café Luxembourg(across the street)

Paranimphs

Alexa Laheija.laheij@acta.nl

Ilona Persooni.persoon@acta.nl