© 2016 Illumina, Inc. All rights reserved.

Unlocking the Power of the GenomeJessica Gordon

Associate Director, SW Eng. | 09/22/2016

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Understanding Genomics

DNA double helix

The four bases:

• Adenine

• Cytosine

• Thymine

• Guanine

Chromosome

Coiled DNA

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What Can We Do by Knowing Your Genome?

Suggest predispositions

and symptomsGuide selection of drug choices

Help inform proactive

health managementProvide family planning insight

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Our Background

FINANCIALS

$2.22B 19%2015 Revenue Revenue Growth YOY

AWARDS

SMARTEST COMPANY2014 MIT TECHNOLOGY REVIEW

10 BREAKTHROUGH

TECHNOLOGIES

2013 MIT TECHNOLOGY REVIEW

12 MOST DISRUPTIVE

NAMES IN BUSINESS

2013 FORBES

TOP 10 INNOVATIONS

2015 THE SCIENTIST MAGAZINE

TOP 10 INNOVATIONS

2012 THE SCIENTIST MAGAZINE

FASTEST GROWING

TECH COMPANIES

2010 FORBES

COMPANY

Fall, 1998FOUNDED

July 27, 2000IPO

~5,000EMPLOYEES

San Diego, CAHEADQUARTERS 20

Francis deSouzaPresident and CEO

OFFICES

GLOBALLY

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Progressing Toward Our MissionClinical adoption is a reality today

For Research Use Only. Not for use in diagnostic procedures.

2005 2006 2007 2008 2009 2010 2011 2012 20132004 2014 2015 2016

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Sequencing By Synthesis Overview

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Illumina PlatformsSEQUENCING SYSTEMS | Sequencing by Synthesis (SBS)

For Research Use Only. Not for use in diagnostic procedures.

FLEXIBLE POWER

NextSeq™ 500/550

POPULATION POWER

HiSeq X™ Five/Ten

PRODUCTION POWER

HiSeq® 2500/3000/4000

ARRAY SCANNER | Infinium

CUTTING-EDGE ARRAY SCANNER

iScan®

* For in vitro diagnostic use

FOCUSED POWER

MiSeq®, MiSeqDx™*, MiSeqFGx™ MiniSeq™

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2014$1,000 1st $1,000 genome

2010$10,000 1st sub-10K genome

2008$200,000 1st 30x genome

2007$2,000,000 1st NGS Genome

2006$20,000,000 1st individual genome

2003$3,000,000,000 Human Genome Project

Cost Per Genome

For Research Use Only. Not for use in diagnostic procedures.

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Source: U.S. National Human Genome Research Institute, Nature

Driving Innovative Sequencing TechnologyBreakthrough technology enables lower sequencing costs

$1000

genome

HiSeq X Ten

Launched

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Leveraging Our TechnologyIntegrated workflows from sample-to-answer

Custom

content

Flexible,

economical

sequencing

Integrated

analysis

Simplified

library prep

SEAMLESS WORKFLOW SOLUTIONS ENABLE MARKETS

For Research Use Only. Not for use in diagnostic procedures.

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BaseSpace®

For Research Use Only. Not for use in diagnostic procedures.

Apps

Public Genomic Databases

Users

EMR

Support & Engineering

Instruments

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BaseSpace®

Sequencing Activity Worldwide

HiSeq ®

MiSeq®

NextSeq™

Cumulative

For Research Use Only. Not for use in diagnostic procedures.

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Who We ServeInnovation drives expanding market opportunities

Research

Forensics Agriculture

Complex Disease

Reproductive Health Oncology

Consumer

Genetic Health BioPharm

Infectious Disease

Population Sequencing

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The Latest in Population-Scale SequencingEnabled by HiSeq X

™

’ s unmatched speed and throughput

$215M investment;

Calls for new era of

precision medicine

White House Initiative for Precision Medicine

$1B to accelerate 10

years of research to

just 5 years

US Cancer Moonshot Task Force

Sequence 100,000

genomes over 4 years

Genomics EnglandChina’s Precision Medicine Initiative

$10B over 15 years;

2 million people

For Research Use Only. Not for use in diagnostic procedures.

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Illumina AcceleratorDriving value for genomics startups

Capital Sequencing Coaching Facility

Hand-selecting the best entrepreneurs that are using genomics

to unlock the power of the genome

www.illumina.com/accelerator

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How Genomics Can Change the FutureJoshua Osborn’s story

Learn More: NY Times June 2014

http://www.nytimes.com/2014/06/05/health/in-first-quick-dna-test-diagnoses-a-boys-illness.html?_r=0

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How Genomics Can Change the FutureLucas Meagu’s story

Learn More: The Telegraph, March 2015

http://www.telegraph.co.uk/news/science/science-news/11495591/First-baby-born-from-IVF-technique-which-eliminates-inherited-disease.html

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How Genomics Can Change the FutureMarin Mejia’s story

Learn More: NBC San Diego January 2015

http://www.nbcsandiego.com/news/local/Firefighters-Wife-Battles-Cancer-After-Giving-Birth-Oceanside-National-City-288265881.html

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Reimagining the Future

There is a dramatic ‘DNA revolution’ happening today and Illumina is leading it.

Our technology and the solutions we continue to bring to market are transforming

our understanding of the genome – and will ultimately transform health care.

– Francis deSouza, 2016