ANNALS OF THE RHEUMATIC DISEASES

failure developed, together with albuminuria, hepato-splenomegaly, persistent pyrexia,and severe, recurrent, bilateral irido-cyclitis. She was transferred to the Canadian RedCross Memorial Hospital in June, 1950. Biopsies of liver, voluntary muscle, and a freshskin eruption all showed many characteristic nodules of sarcoidosis. Renal functiontests show low renal reserve, her present blood pressure varies between 260/140and 160/115, and pyrexia and recurrent exacerbations of irido-cyclitis persist. Duringthe past two years, five Mantoux tests at a dilution of 1: 100 have all been negative.

LIGUE EUROPEENNE CONTRE LE RHUMATISME

A professorship in rheumatology has been established at the University ofLouvain, Brussels. Dr. Leon Michotte, vice-secretary-general of the LigueEuropeenne contre le Rhumatisme, has been appointed Professor of Rheumatology.

UNIVERSITY OF PARISCHAIR OF CLINICAL RHEUMATOLOGY

A course of lectures and demonstrations in rheuma.ology is to be held at the HopitalCochin, Paris, from January 29 to February 4, 1951, under the direction of ProfessorF. Coste, from whom the following information has been received.

Le matin auront lieu, de 9 h. 30 'a 12 h. 30, les demonstrations pratiques dont deuxseront consacrees 'a la clinique, deux a la lecture commentee de radiographiques, et uneaux techniques de laboratoire.

L'apres-midi auront lieu, de 14 h. 30 it 17 h. 30, les conferences theoriques dansl'ordre suivant:

Le 29 et 30 Janvier (avec le concours des Drs. F. Layani, J. Forestier, S. de Seze,et F. Delbarre): " Les facteurs endocriniens en rhumatologie-Cortisone et ACTH."

Le 31 Janvier (avec le concours des Drs. P. Delaunay et J. Durel): " Les facteursinfectieux en rhumatologie."

Le 1 Fevrier (avec le concours du Prof. Merle-d'Aubigne, des Drs. L. Rubens-Duval et P. Galmiche): " Probleme concernant les arthroses-les coxarthroses."

Le 2 Fevrier (avec le concours du Prof. agr. S. de Seze, des Drs. J. Lievre etA. Lacapere): " Pathologie vertebrale et discale."

Ces conferences seront suivies de la discussion des questions posees par les auditeurs.Les inscriptions (Prix 3,000 fr.) seront reques a la Faculte de Medecine. Pour tous

renseignements, ecrire au Dr. P. Galmiche, Hopital Cochin, 27 rue du Faubourg-St.-Jacques, Paris, XIVe.

382

ANNALS OF THE RHEUMATIC DISEASESDR. BAUER: In the future we may all agree that when you stop long-continued cortisone

therapy you should give ACTH for a while. In patients who have been on cortisone for five orsix months tests of adrenal cortical function usually reveal the presence of some insufficiency.

CHAIRMAN: In some cases of Cushing's disease of long-standing duration one adrenal hasbeen hypertrophied and the contralateral adrenal has been atrophied for many years. But aftersurgical removal of the adrenal tumour the remaining adrenal (after a period of adrenal insuffi-ciency which has to be cared for specifically) has come back and functioned normally.

DR. BAUER: That still does not mean we shall not have some real emergencies.DR. ENGLEMAN: I think it is interesting that patients who have had hypopituitarism for years

respond beautifully to ACTH.DR. STEINBROCKER: Much more information is needed on this very important subject. We

have interrupted cortisone therapy to give ACTH at different times in the investigative period,and have not encountered any periods when patients were refractory to ACTH. When we didnot give enough ACTH the patient appeared to be " refractory ". If we gave enough ACTH heresponded, regardless of how long he had received cortisone.

DR. BAUER: We should test adrenal function regularly to learn whether or not we have inducedadrenal insufficiency, and, if so, to what degree.

DR. WALLACE GRAHAM: What about the effect of these hormones on subacromialbursitis ?

DR. STEINBROCKER: I have not treated that condition.DR. PHILIP LEWIN: Inhibition of the production of fibroblasts during the use of cortisone

was described to us at the American Orthopaedic meeting. In doing arthroplastics of the knee,for example, with oxycel as a membrane, one investigator uses cortisone locally to inhibit theproduction of fibroblasts which produce adhesions.

DR. KUZELL: What is the incidence of haemorrhagic complications in people treatedwith cortisone ?

CHAIRMAN: We have had slight purpuric reactions of the skin in two of our first 23 cases.DR. BAUER: Purpura can be a manifestation of rheumatoid arthritis.

DR. EDWARD BOLAND: Can cortisone be administered subcutaneously?

DR. ENGLEMAN: I can't answer that question, but ophthalmologists say that subconjunctivalinjections of cortisone and also local instillations of cortisone as eye-drops are effective.

NOTICE

Merck and Co., Inc., of Rahway, New Jersey, U.S.A., announce that Cortone (theMerck brand of cortisone) will be made generally available on or about November 1through distributors, hospitals, institutions, and pharmacies for use by the physician inhis daily practice. The company also announce a further price reduction to take effectimmediately. The suggested list price to physicians is now $35 per gramme. The pricecharged to hospitals during the past few months has been $50 per gramme. The companyhas thus succeeded in reducing the price of Cortone to less than one-fifth of that chargedto investigators a little over a year ago. These savings have been accomplished throughresearch and process improvements.

In rheumatoid arthritis, where prolonged treatment with Cortone is usually required,clinical investigations now indicate that almost all patients can be maintained on 0 1 g.daily, and some patients on as little as 0 - 05 g. daily.

414

ANNALS OF THE RHEUMATIC DISEASESRheumatism. A series of Broadcast talks given by " a doctor ". With a foreword

by Lord Horder. 1950. Pp. 47. Published by the Empire Rheumatism Council.Is.This pamphlet, containing talks on the rheumatic diseases, for which facilities were

granted by the B.B.C., has created wide interest and has already gone into several editions.The chief forms of rheumatism are clearly described in language which can be readilyunderstood by the layman and in a style which is graphic and interesting. The mainsymptoms and characters of rheumatic fever, fibrositis, sciatica, neuritis, rheumatoidarthritis, osteo-arthritis, spondylitis, and gout are each dealt with in turn and there is afinal chapter on the latest discoveries which have aroused such wide interest and hopefor the better treatment of rheumatoid arthritis as well as of other conditions. So far asthey are known the causes of rheumatic disease are summarized. Sound advice is givenon things which should be avoided, the most suitable diet, the need for rest in bed in thetreatment of very many cases of rheumatoid arthritis, the serious effects of neglectingrheumatic fever in even its mildest forms, and the effects of physical overstrain. Sufferersfrom any form of rheumatism cannot fail to read this brochure with interest and to benefitfrom the information it supplies.

Annotated Bibliography of Cortisone, ACTH and Related Hormonal Substances. Pub-lished quarterly by the Cortisone Committee of the Empire Rheumatism Council.Last Quarter, 1950. 5s.This publication deals with the literature of the subject, very extensive though of

unequal value, which has appeared in English-language journals up to August, 1950.Fairly full abstracts of the more important papers are given and those of less value receivebrief notice. Those who wish to keep abreast of research work into the physiologicaland pharmacological action of these substances and their possible therapeutic use in manymorbid conditions, a difficult task in such an extensive and expanding field, will find thisquarterly very useful in that it indicates which of the published papers are worthy ofcloser study, and gives some idea of their general scope.

It is intended to publish further instalments at quarterly intervals, they may be obtainedfrom the General Secretary, Empire Rheumatism Council, Tavistock House North,Tavistock Square, London, W.C.I.

BRITISH RHEUMATIC ASSOCIATION

We have received a copy of the August issue of the B.R.A. Review, the new quarterlyjournal of the British Rheumatic Association. This publication is well produced andcontains much useful information which will be read with interest and profit by thelayman and probably also by general practitioners.

416

INDEX TO VOLUME IX

ACTH:administration, dosage and schedule of, 11antirheumatic effects of, 8complement, gamma globulin, and fibrinogen, effects on, inrheumatoid arthritis, scleroderma and lupus erythematosus dis-seminatus (J. H. Vaughn and others), 399

historical notes on, 4metabolic and immunological effects of, 10metabolic changes during administration of (W. D. Robinson and

others), 398neoplastic disease, in (0. H. Pearson and others), 253preparation of, 317Reiter's syndrome, in (W. Graham and M. Ogryzlo), 401rheumatic fever, in (B. F. Massell and J. E. Warren), 392rheumatic arthritis, in, 393 bis

ACTH and cortisone:connective tissue, effect on (C. Ragan and others), 254haematological effects in rheumatic diseases (S. Finch and others),

398Heberden Society lecture on, 380neoplastic disease, in (O. H. Pearson and others), 253rheismatic disease, in (Panel Discussion, Amctican Rheumatism

Association), 407rheumatic diseases and, 7rheumatic fever, effects of, in, 252rheumatoid arthritis, in, 252, 389, 394

Adaptation syndrome, general, stress and, 246ADAMS, C. H., see FREYBERo, R. H., ADAMS, C. H., DURIVAGE, J.,and TRAEGER, C. H.

Adrenal cortex:activity and immune responses (E. E. Fischel), 254experimental data implicating, in pathogenesis of rheumatic

disease, 5relation to rheumatic disease (E. W. Boland), 1steroids, experiences in rheumatoid arthritis (E. F. Rosenberg), 393

Adrenal extracts, metabolic changes during administration of (W. D.Robinson and others), 398

Agglutinating factor for sensitized sheep erythrocytes. rheumatoidarthritis patients, in, 377

Anaemia of rheumatoid arthritis, iron therapy in, 358Airmen, rheumatic fever in (C. Ounsted), 159American Rheumatism Association, procecdings of Annual Meeting,

1950, 383Anti-arthritic agents, use of intra-articular temperature management in

evaluation of (J. L. Hollander and others), 401" Anti-stiffness factor ", relation to collagen disease and calcinosis, 97APPEL, S. B., see McEwEN, C., BUNIM, J. J., BALDWIN, J. S., KuTTNER,

A. G., APPEL, S. B., and KALTMAN, A. J.Arthritis:

chronic absorptive, or opera-glass hand (W. M. Solomon andR. M. Stecher), 209

rheumatoid, see Rheumatoid arthritissymptomatic, due to hypertrophic pulmonary osteo-arthropathy inpulmonary neoplastic disease (H. H. Holmes and others), 169

Artisone and synovial membrane permeability, 403ASBOE-HANsEN, G.: Origin of synovial mucin. Ehrlich's mast cell-

a secretory element of the connective tissue, 149Ascorbic acid and desoxycorticosterone acetate in rheumatoid arthritis

(M. K. Newman), 404

BAEHR, G., and SOFFER, L. J.: Treatment of disseminated lupuserythematosus with cortisone and adrenocorticotropin, 252

BAL, effects of 2, 3-dimercapto-propanol on gold reactions (G.Edstrom), 109

BALDWIN, J. S., see MCEWEN, C., BUNIM. J. J., BALDWIN, J. S.,KUTrNER, A. G., APPEL, S. B., and KALTMAN, A. J.

BALL, J., see KELLGREN, J. H., and BALL, J.BAUMAN, E., see HOLMES, H. H., BAUMAN, E., and RAOAN, C.BAYLES, T. B., see VAUGHN, J. H., FAVOUR, C. B., and BAYLES, T. B.

see FINCH, S., CROCKETT, C. L., Jr., STOUT, C. F., Ross, J. F.,and BAYLES, T. B.

Belgian League against Rheumatism, see Ligue Belge contre leRhumatisme

BLOCK, W. D., see ROBINSON, W. D., DUFF, I. F., BLOCK, W. D., andFOSTER, P. W.

BLUNT, J. W., see PLOTZ, C. M., BLUNT, J. W., LASrES, R., andRAGAN. C.

see RAGAN, C., HowEs, E. L., PLOTZ, C. M., MEYER, K., BLUNT,J. W., and LATTES, R.

BOODANOVITCH, A., see HART, F. D., BOGDANOVITCH, A., and NICHOL,W. D.

BOLAND, E. W.: Relation of adrenal cortex to rheumatic disease, 1and HEADLEY, N. E.: Management of rheumatoid arthritis with

smaller " maintenance " doses of cortisone, 394BOOK REviEws:

BRITISH RHEUMATIC ASSOCIATION:Proceedings: The scourge of rheumatism, 258BRA Review, 416

COLLINS, D.: The pa'thology of articular and spinal diseases, 1949,181

COMROE, B. I., rev. HOLLANDER, J. L.: Arthritis and allied condi-tions, 1949. 83

CROWE, H. WARREN: Rheumatism, 2nd ed., 1949. 82EMPIRE RHEUMATISM COUNCIL, CORTISONE CoMMIrrEE: Annotated

Bibliogranhv of Cortisone, ACTH, and Related Hormonal Sub-stances, 1950. 416

HOSPrTAL REPORTS:West London Hospital, Department of Rheumatic Diseases,

1949, 259Royal Free Hospital, Unit of Rheumatology, 1949. 259Royal National Hospital for Rheumatic Diseases, Bath.

Vol. 3, 1948-9, 259JARVINEN, K. A. J.: Investigations on the relations of rheumatoid

arthritis and rheumatic fever to allergy, 1950, 415MERCK Manual of diagnosis and therapv. 8th ed., 1950, 258RHEUMATISM: A series of broadcast talks given by "' a doctor

1950, 416WEBER, F. PARKES: Further rare diseases and debatable subjects,

1949, 81British Branch of the European League against Rheumatism, see LigueEuropdenne contre le Rhumatisme

British Rheumatic Association, 258; BRA Review, 416BROWN, E. M., Jr., see HOLLANDER, J. L., STONER, E. K., BROWN,

E. M., Jr., and DEMoos, P.Buchtal, work on fibrositis of muscles, 67BUNIM, J. J., SOKOLOFF, L., and WILENS, S. L.: Vascular lesion

observed in rheumatoid arthritis, 388see MCEWEN, C., BUNIM, J. J., BALDWIN, J. S., KUrrNER, A. G.,APPEL, S. B., and KALTMAN, A. J.

Calcinosis, relation of " anti-stiffness factor " to collagen disease and(J. Lansbury and others), 97

Calcium ortho-iodoxybenzoate, clinical trial of (G. D. Kersley andN. R. W. Simpson), 174

Canadian Rheumatism Association: Officers, 1950-1, 257Chrondromalacia patellae (D. C. Ensign and J. M. Sigler), 402Colchicine therapy, in an unusual case of gout, 282Collagen disease and calcinosis, relation of " anti-stiffness factor " to

(J. Lansbury and others), 97CONN, J. W., see RoBINSoN, W. D., CONN, J. W., Louis. L.,JOHNSON, B. J.. and DUPF, I. F.

Connective tissue:effect of ACTH and cortisone on (C. Ragan and others), 254effect of steroid hormones on growth of (C. M. Plotz and others),

399Ehrlich's mast cell-a secretory element of, 149ground substances of. 383

CONSTANTINE, A. G., see NORCROSS, B. M., LocKIE, L. M., CONSTAN-TINE, A. G., and STEIN, R. H.

CORN, O., see FITCH, D. R., WARTER, P. J., SEIFTER, J., JALLO, S.,and CoRN, 0.

Corticostimuline hypophysaire, etude d'une (F. Coste and F. Delbarre),317

Cortisone:administration, dosage and schedule of, 11antirheumatic effects of, 7effect on muscle lesions and rheumatoid nodules in patients withrheumatoid arthritis (B. M. Norcross and others), 389

historical notes on, 2metabolic change during administration of (W.D. Robinson and

others), 398metabolic and immunological effects of, 10neoplastic disease, in (0. H. Pearson and others), 253

439

ANNALS OF THE RHEUMATIC DISEASESCortisone-conttinseed:

rheumatoid arthritis, experiences in, with (E. F. Rosenberg), 393rheumatoid arthritis, management with smaller ' maintenance"

doses of (E. W. Boland and N. E. Headley), 394Cortisone and ACTH:

connective tissue, effect on, 254disseminated lupus erythematosus, in, 252rheumatic diseases, effects of, on, 7, 380, 398rheumatic disease, in (Panel Discussion, American Rheumatism

Association), 407rheumatic fever, effect of, on (C. H. McEwen and others), 252rheumatoid arthritis, in, 252, 389, 394rheumatoid arthritis, 393 bisrheumatoid arthritis. practical considerations of usc of, for (R. H.

Freyberg and others), 394Cortone, availability and price of, 414COSTE, F., and DELBARRE, F.: etude d'une corticostimuline hypo-

physaire, 317and LACRONIQUE, F.: Traitements hypophysosurrdnaux des poly-

arthrites chroniques evolutives et de la spondylarthrite ankylo-sante, 305

Coxarthritis, further anatomical check on accuracy of intra-articularhip injections in therapy of (M. M. Dobson), 237

Creatine excretion in urine of 38 untreated ambulant male patientswith fibrositis and in two healthy men (O. Sylvest and N. Hvid-Hansen), 241

CROCKETT, C. L., Jr., see FINCH, S.. CROCKETT. C. L., Jr., STOUT, C. F.,Ross, J. F., and BAYLES, T.

Danish Association against Rheumatic Disease. see National DanishAssociation against Rheumatic Disease

DELBARRE, F., see COSTE, F., and DELBARRE, F.DEMOOR. P., see HOLLANDER, J. L., STONER, E. K., BROWN, E. M., Jr.,and DEMOOR, P.

Dermatomyositis and ACTH, 16Desoxycorticosterone acetate and ascorbic acid in rheumatoid arthritis

(M. K. Newman), 404Diabetes mellitus, study of inter-relations of rheumatoid arthritis and

(K. A. J. Jarvinen), 226DOBSON. M. M.: A further anatomical check on accuracy of intra-

articular hip injections in therapy of coxarthritis, 237DUFF, I. F., see ROBINSON, W. D., DUFF, I. F., BLOCK, W. D., and

FOSTER, P. W.see ROBINSON, W. D., CONN. J. W., Louis, L., JOHNSON, B. J.,and DUFF, I. F.

DUFFY, M., see ISHMAEL, W. K., HELLBAUM, A., KUHN, J. F., OWENS,J. N., Jr., and DUFFY, M.

DURIVAGE, J., see FREYBERG, R. H., PATTERSON, M., ADAMS, C. H.,DURIVAGE, J., and TRAEGER, D. H.

DUTHIF, J. J. R., and SWANSON, J. N.: Clinical trial of para-amino-salicyclic acid in treatment of rheumatoid arthritis, 132

EDSTROM, G.:Effects of 2, 3-dimercapto-propanol (BAL) on gold reactions, 109Pituitary gland implantations in rheumatoid arthritis, 22

Ehrlich's mnast cell-a secretory element of connective tissue, 149ELIEL, L. P., see PEARSON, 0. H., ELIEL, L. P., and TALBOT, T. R., Jr.ELLMAN, P., and SHAW, D.: The " chronic rheumatic " and his pains,

341Empire Rheumatic Council:

13th Annual Report, 176Vice-President, 76Cortisone Committee, 416

European League against Rheumatism, see Ligue Europeenne contreIc Rhumatisme

ENSIGN, D. C., and SIGLER, J. M.: Chondromalacia patellae, 402

FAVOUR, C. B., see VAUGHN, J. H., FAVOUR, C. B.. and BAYLES, T. B.Fibrositis:

creatine excretion in urine of 38 untreated ambulant male patientswith (O. Sylvest and N. Hvid-Hansen), 241

of muscles (K. Jespersen), 66FINCH, S., CROCKETT, C. L., Jr., STOUT, C. F., Ross, J. F., and BAYLES,

T. B.: Haematological effects in patients with rheumatic diseasestreated with ACTH and cortisone, 398

FISCHEL, E. E.:Relationship of adrenal cortical activity to immune responses, 254

Salicylate administration in relation to activity in rheumatic fever,390

FITCH, D. R., WARTER, P. J., SEIFTER, J., JALLO, S., and CoRN, O.:Effect of hyaluronidase and various steroid hormones on human

synovial membrane permeability and clinical results with artisone,403

FORESTIER, J., and ROTES-QUEROL, J.: Senile ankylosing hyperostosisof the spine, 321

FOSTER, P. W., see ROBINSON, W. D., DUFF, I. F., BLOCK, W. D.,

and FOSTER, P. W.

FRASER, T. N.: Ankylosing spondylitis in sisters, 231

FREYBERG, R. H.:

Effects of cortisone and ACTH in rheumatoid arthritis, 252

PATrERSON. M.. ADAMS, C. H., DURIVAGE, J., and TRAEGER,C. H.: Practical cdnsiderations of use of cortisone and ACrHfor rheumatoid arthritis, 394

Glucuronic acid, effect of, on serum lipid and protein fractions in

diseases of the mesenchyme (I. Leinwand), 386

Glycine and treatment of gout (F. Wrigley), 38

Gold:

reactions, effects of 2, 3-dimercapto-propanol (BAL) (G.

Edstrom), 109

treatment of polyarthritis, experiments in gold-testing (T. Svan-

berg), 221

GORDON, R. G., obituary, 279

Gout:

ACTH and cortisone and, 16

classical (Heberden Oration), 7t

glycine and treatment of, 38

unusual case with softening and subluxation of first cervical vcrtebraand splenomegaly (G. D. Kersley and others), 282

GRAHAM, W., and OGRYZLO, M.: Reiter's syndrome: administration

of ACTH, 401Ground substances of connective tissue, further studies (K. Meyer and

M. M. Rapport), 383

Haematological effects in patients with rheumatic diseases with

ACTH and cortisone (S. Finch and others), 398

HART, F. D., BOGDANOVITCH, A., and NICHOL, W. D.: in

ankylosing spondylitis, 116

HEADLEY, N. E., see BOLAND, E. W., and HEADLEY, E.

Heberden Society:

Annual Meeting, December, 1949; Officers 1950, 71

Annual Report, 1949-50, 177

Clinical Meetings, Janusry, 1950, 73; March, October,

1950, 380

Lecture. October, 1950, 380

Medal, award for 1949, 72

Oration, December, 1949, 71: June, 1950. 246

Round, Paris, May, 1950, 249

HELLBAUM, A., see ISHMAEL, W. K., HELLBAUM, A., KUHN, J. F.,

OWENS, J. N., Jr., and DUFFY, M.

HENCH, P. S.:

Lecture to Heberden Society, 380

Nobel Prize awarded to, 281

see SLOCUMB, C. H., POLLEY, H. P., HENCH, S., KENDALL,E. C.

HIGHTON, T. C., see MAUNSELL. K., WRIGLEY, F., HIGHTON, C.,and HOLT, L. B.

HOLLANDER, J. L., STONER, E. K., BROWN, E. M., DEMOOR,

P.: Use of intra-articular temperature managementof

anti-arthritic agents, 401

HOLMES, H. H., BAUMANN, E., and RAGAN, C.: Symptomatic

due to hypertrophic pulmonary osteoarthropathy pulmonary

neoplastic disease, 169

HOLT, L. B., see MAUNSELL, K., WRIGLEY, F., HIGHTON, and

HOLT, L. B.

HOWES, E. L.. see RAOAN, C., HoWES, L., PLOTZ, MEYER,

K., BLUNT, J. W., and LATTES, R.

HvID-HANSEN, N., see SYLVEST, O., and HvID-HANSEN, N.

Hyaluronidase:

activity in skin, rheumatic disease, and salicylates (E. Jones), 137

effect of, on synovial membrane permeability,

Hyperadrenalism, sigas of, from cortisone ACTH,

Hyperostosis of the spine, senile ankylosing,

Immune responses, adrenal activity (E. Fischel),Injections, intra-articular hip,

International League against

contre le Rhumatisme

Iron therapy, oral and intravenous,

(D. N. Ross). 358

Italian Society for the Study Societastudio del reumatismo

ISHMAEL, W. K., HELLBAUM, A., KuHN, F., N., Jr.,DUFFY. M.: Further observations

sterone and pregnenolone

orders, 406

JALLO, S., see FITCH, D. R., WARTER, P. J., SEIFTER, J., JALLO, S.,

and CoRN, 0.

JARL0V, E., and JARL0V, N. V.: Investigations

latory and metabolic phenomena,

JARL0V, N. V., see JARL0V, E., JARL0V,JARVINEN, K. A. J.: Study

and diabetes mellitus, 226

440

INDEXJEFFREY, M. R., see KERSLEY, G. D., MANDEL, L., and JEFFREY, M. R.JESPERSEN, K.: Fibrositis of muscles, 66JOHNSON, B. J., see ROBINSON, W. D., CONN, J. W., Louis, L.,JOHNSON, B. J., and DUFF, I. F.

Joints, synovial membrane, in human arthritic, 363JoNEs, E. S.: Hyaluronidase activity in skin, rheumatic disease, and

salicylates, 137JONES, F. WOOD: Classical gout (Heberden Oration), 71

KALTMAN, A. J., see McEWEN, C., BUNIM, J. J., BALDWIN, J. S.,KurrNER, A. G., APPEL, S. B., and KALTMAN, A. J.

KELLGREN, J. H., and BALL, J.: Tendon lesions in rheumatoid arthritis,48

KENDALL, E. C., see SLOCUMB, C. H., POLLEY, H. F., HENCH, P. S.,and KENDALL, E. C.

KERSLEY, G. D., MANDEL, L., and JEFFREY, M. R.: Gout, unusual casewith softening and subluxation of first cervical vertebra and spleno-megaly, 282

and SIMPSON, N. R. W.: Clinical trial of calcium ortho-iodoxy-benzoate, 174

KUHN, J. F., see ISHMAEL, W. K., HELLBAUM, A., KUHN, J. F.,OWENS, J. N., Jr., and DUFFY, M.

KUTTNER, A. G., see McEwEN, C., BUNIM, J. J., BALDWIN, J. S.,KUTTNER, A. G., APPEL, S. B., and KALTMAN, A. J.

LACRONIQUE, F., see CosTE, F., and LACRONIQUE, F.LANSBURY, J., SMITH, L. W., WULZEN, R., and VAN WAGTENDONK, W.:

Relation of ' anti-stiffness factor " to collagen disease and calcinosis,97

LATHAM, L. S., obituary, 176LArrEs, R., see PLOTZ, C. M., BLUNT, J. W., LATTES, R., and

RAGAN, C.see RAGAN, C.. HowEs, E. L., PLoTz, C. M., MEYER, K., BLUNT,

J. W., and LATTES, R.LEINWAND, I.: Effect of glucuronic acid on serum lipid and protein

fractions in diseases of the mesenchyme, 386Ligue Belge contre le Rhumatisme, 257Ligue Europdenne contre le Rheumatisme, 78, 255, 256, 382

British branch of: Clinics, 78, 180Ligue Internationale contre le Rhumatisme, 77, 255LoCKIE, L. M., see NoRCRoss, B. M., LocKIE, L. M., CONSTANTINE,

A. G., and STEIN, R. H.Louis, L., see ROBINSON, W. D., CONN, J. W., LOUIs, L., JOHNSON,

B. J., and DUFF, I. F.LUCCHESI, M., and LucCHEsI, O.: Rheumatoid spondylitis, a paediatric

problem, 372LUCCHESI, O., see LUCCHESI, M., and LuCCHESI, 0.Lupus erythematosus, disseminated:

and ACTH, 15ACTH, effects of, on (J. H. Vaughn and others), 399cortisone and adrenocorticotropin, treatment with (G. Baehr and

L. J. Soffer), 252

McEwEN, C., BUNIM, J. J., BALDWIN, J. S., KUTTNER, A. G., APPEL,S. B., and KALTMAN, A. J.: Effect of cortisone and ACTH onrheumatic fever, 252

MANDEL, L., see KERSLEY, G. D., MANDEL, L., and JEFFREY, M. R.Mast cells, Ehrlich's, 151MASSEL, B. F., and WARuEN, J. E.: ACTH in rheumatic fever, 392MAUNSELL, K., WRIGLEY, F., HIGHTON, T. C., and HOLT, L. B.:

Synovial membrane, 363Mesenchyme, effect of glucuronic acid on serum lipid and protein

fractions in diseases of the (I. Leinwand), 386Metabolic changes during administration of ACTH, cortisone and

adrenal extracts (W. D. Robinson and others), 398phenomena, Investigations into peripheral circulatory and (E.

Jarl0v and N. V. Jarl0v). 28MEYER, K., and RAPPORT, M. M.: Further studies in ground sub-

stances, 383see RAGAN, C., HowEs, E. L., PLOTZ, C. M., MEYER, K., BLUNT,

J. W., and LATrES, R.Mucin, synovial, origin of (G. Asboe-Hansen), 149Muscle lesions, effect of cortisone on, in rheumatoid arthritis, 389Muscles, fibrositis of, 66

National Danish Association against Rheumatic Disease: AnnualReport, 1948-9, 180

Neoplastic disease:pulmonary, Symptomatic arthritis due to hypertrophic pulmonary

osteo-arthropathy in (H. H. Holmes and others), 169ACTH and cortisone, use of, in (O. H. Pearson and others), 253

Neurotic symptoms in chronic non-articular rheumatism, 343NEWMAN, M. K.: Desoxycorticosterone acetate and ascorbic acid inrheumatoid arthritis, 404

New York Academy of Medicine:Meeting, 75Symposium on cortisone and ACTH, 180, 252

441New York Rheumatism Association:

Meetings, 75Annual Meeting, 1950, 179

NICHOL, W. D., see HART, F. D., BOGDANOVITCH, A., and NICHOL,W. D.

Nobel Prize award to P. S. Hench, 281NORCROSS, B. M., LOCKIE, L. M., CONSTANTINE, A. G., and STEIN,

R. H.: Effect of cortisone on muscle lesions and rheumatoidnodules in patients with rheumatoid arthritis, 389

OBITUARY:Gordon. R. G., 279Latham, L. S., 208Ray, M. B., 280

OGRYZLO, M., see GRAHAM, W., and OGRYZLO, M.Opera-glass hand, 209Osteo-arthropathy, hypertrophic pulmonary, 169OUNSTED, C.: Rheumatic fever in airmen: stigma analysis with some

controlled observations on convalescent depression and arthralgia,159

Overwork-fibrositis. explanation of, 68OWENS, J. N., Jr., see ISHMAEL, W. K., HELLBAUM, A., KUHN, J. F..OWENs, J. N., Jr., and DuFFY, M.

Para-amino-salicyclic acid, clinical trial of, in treatment of rheumatoidarthritis (J. J. R. Duthie and J. N. Swanson), 132

Paediatrics, rheumatoid spondylitis, a problem in, 372Pan American League against Rheumatism, 78Paris, University of, chair of clinical rheumatology, 382PATTERSON, M., see FREYBERO, R. H., PATTERSON, M., ADAMS, C. H..DURIVAGE, J., and TRAEGER, C. H.

PEARSON, 0. H., ELIEL, L. P., and TALBOT. J. R., Jr.: ACTH andcortisone in neoplastic disease, 253

Periarteritis nodosa and ACTH, 15Peripheral circulatory and metabolic phenomena, 28Pituitary-adrenal:

function stimulation in treatment of rheumatoid arthritis andankylosing spondylitis (F. Coste and F. Lacronique), 305

system (J. A. Russell), 253Pituitary gland implantations in rheumatoid arthritis (G. Edstrom), 22PLOTZ, C. M., BLUNT, J. W., LATTES, R., and RAGAN, C.: Effect of

steroid hormones on growth of connective tissue, 399see RAOAN, C., HOWEs, E. L., PLOTZ, C. M., MEYER, K., BLUNT,

J. W., and LATTES, P,.POLLEY, H. F., see SLOCUMB, C. H., POLLEY, H. F., HENCH, P. S.,and KENDALL, E. C.

Polyarthritis, Experiments in gold-testing in gold treatment of (T.Svanberg), 221

Polytendovaginitis, rheumatic (I. L. Sperling), 43Pulmonary osteo-arthropathy, 169Pregnenolone in rheumatoid arthritis (W. K. Ishmael and others), 406Psoriasis and psoriatic arthritis, cortisone and ACTH, in, 14Psychiatric features of chronic non-articular rheumatism, 346Psychosomatic aspects of chronic non-articular rheumatism, 341

RAGAN, C., HowEs, E. L., PLoTz, C. M., MEYER, K., BLUNT, J. W.,and LATTES, R.: Effect of ACTH and cortisone on connectivetissue, 254

see HOLMES, H. H., BAUMAN, E., and RAGAN, C.see PLOTZ, C. M., BLUNT, J. W., LATTES, R., and RAGAN, C.

RAPPORT, M. M., see MEYER, K., and RAPPORT, M. M.RAY, M. BuRRow, obituary, 280Reduction time " of blood of skin and its relation to basal meta-bolism of organism, 28

Rei,tr's syndrome, administration of ACTH in (W. Graham andM. Ogryzlo), 401Rheumatic, The chronic " and his pains (P. Ellman and D. Shaw),341

Rheumatic disease:adrenal cortex in relation to (E. W. Boland), 1cortisone and ACTH in (Panel Discussion, American Rheumatism

Association), 407haematological effects in patients with, treated with ACTH and

cortisone (S. Finch and others), 398hyaluronidase activity in (E. S. Jones), 137

Rheumatic fever:ACTH in (B. F. Massell and J. E. Warren), 392acute, and cortisone and ACTH, 14, 252airmen, in: stigma analysis with some controlled observations on

convalescent depression and arthralgias (C. Ounsted), 159salicylate administration in relation to activity in (E. E. Fischel).

390Rheumatic polytendovaginitis (I. L. Sperling), 43Rheumatism, chronic non-articular, 341Rheumatoid arthritis:

ACTH, effects of, on complement, gamma globulin, and fibrinogenin (J. H. Vaughn and others), 399

ANNALS OF THE RHEUMATIC DISEASESRheumatoid arthritis-continued:

ankylosing spondylitis and, treatment depending on stimulation ofpituitary-adresal function (F. Coste and F. Lacronique), 305

cortisone and, management with smaller " maintenance" doses(E. W. Boland and N. E. Headley), 394

cortisone, other adrenal cortical steroids and ACTH, and (E. F.Rosenberg), 393

cortisone effect on muscle lesions and rheumatoid nodules inpatients with (B. M. Norcross and others), 389

cortisone and ACTH, effects of, in, 252cortisone and ACTH, further experiences with (C. H. Slocumband others), 393

cortisone and ACTH, practical considerations of use, in (R. H.Freyberg and others), 394

desoxycorticosterone acetate and ascorbic acid in (M. K. Newman),404

diabetes mellitus and, study of the interrelations of (K. A. J.Jarvinen), 226

electrophoretic pattern of plasma proteins in (W. D. Robinsonand others), 383

iron therapy, oral and intravenous, in, 358juvenile, 13, 372muscle lesions in, 389para-amino-salicyclic acid in treatment of (J. J. R. Duthie and

J. N. Swanson), 132pathogenesis of, a theory of (A. D. Wallis), 331patients, agglutinating factor for sentitized sheep erythrocytes inserum and joint fluid from (Svartz and Schlossmann), 377

pituitary gland implantations in, 22pregnenolone in, 406psoriasis and psoriatic arthritis and: treatment with cortisone andACTH, 14

tendon lesions in, 48testosterone in, 406vascular lesion observed in (3. J. Bunim and others), 388

Rheumatoid spondylitis, a paediatric problem (M. Lucchesi and0. Lucchesi), 372

ROBINSON, W. D., CONN, J. W., Louts, L., JOHNSON, B. J., andDUFF, I. F.: Metabolic changes during administration of ACTH,cortisone, and adrenal extracts, 398DUFF, I. F., BLOCK, W. D., and FOSTER, P .W.: Electrophoretic

pattern of plasma proteins in rheumatoid arthritis, 383ROSENBERG, E. F.: Rheumatoid arthritis, experiences with compoundE (cortisone) and other adrenal cortical steroids and pituitaryadrenocorticotropic hormone, 393

Ross, D. N.: Oral and intravenous iron therapy in anaemia ofrheumatoid arthritis, 358

Ross, J. F.. see FINCH, S., CROCKETT. C. L., Jr., Ross, J. F., andBAYLES, T. B.

ROTES-QUEROL, J., see FORESTIER, J., and ROTES-QUEROL, J.RUSSELL, J. A.: Pituitary-adrenal system, physiology of, 253

Salicylate administration in relation to activity in rheumatic fever (E. E.Fischel), 390

Salicylates and hyaluronidase activity (E. S. Jones), 137SCHLOSSMANN, K., see SVARTZ, N., and SCHLOSSMANN, K.Scleroderma, effects of ACTH in (J. H. Vaughn and others), 399SEIFTER, J., see FITCH, D. R., WARTER, P. J., SEIFrER, J., JALLO, S.,and CORN, 0.

SELYE, H.: Stress and general adaptation syndrome (Heberden Oration),246

SHAW, D., see ELLMAN, P., and SHAW, D.SIGLER, J. M., see ENsIGN, D. C.. and SrGLER, J. M.SIMPSON, N. R. W., see KERSLEY, G. D.. and SIMPSON, N. R. W.Skin:

hyaluronidase activity in, 137reduction time " of blood of, and its relation to basal metabolismof organism, 28

SLOCUMB, C. H., POLLEY, H. F., HENCH, P. S., and KENDALL, E. C.:Further experiences with cortisone and ACTH in study of rheumatoidarthritis, 393

SMITH, L. W., see LANSBURY, J., SMITH, L. W., WULZEN, R., andVAN WAGTENDONK, W. J.

SocietiA Italiana per lo studio del reumatismo: Congress, 1950, 257

SOFFER, L. J.. see BAEHR, G., and SOFFER, L. J.

SOKOLOFF, L., see BUNIM, J. J., SOKOLOFF, L., and WILENS, S. L.SOLOMON, W. M., and STECHER, R. M.: Chronic absorptive arthritis

or opera-glass hand, 209SPERLING. I. L.: Rheumatic polytendovaginitis, 43Spine, senile ankylosing hyperostosis of the (J. Forestier and J. Rotes-

Querol), 321Splenomegaly in an unusual case of gout, 282Spondylitis, ankylosing:

rheumatoid arthritis and, treatment by stimulation of pituitary-adrenal function (F. Coste and F. Lacronique), 305

sisters, in (T. N. Fraser), 231thorax in (F. D. Hart and others), 116

Spondylitis:rheumatoid, 14rheumatoid, a paediatric problem (M. Lucchesi and 0. Lucchesi),

372STECHER, R. M., see SOLOMON, W. M.. and STECHER, R. M.STEIN, R. H., see NORCROSS, B. M., LOCKIE, L. M., CONSTANTINE,A. G., and STEIN, R. H.

Steroid hormones, effect of:on growth of connective tissue (C. M. Plotz and others). 399on synovial membrane permeability, 403

Still's disease, 13STONER, E. K., see HOLLANDER, J. L., STONER, E. K., BROWN, E. M.,

Jr., and DEMooR, P.STOUT, C. F., see FINCH, S., CROCKETT, C. L., Jr., STOUT, C. F..

Ross, J. F., and BAYLES, T. B.Stress and general adaptation syndrome (H. Selye). 246SVANBERG, T.: Experiments in gold-testing in gold treatment of poly-

arthritis, 221SVARTZ, N., and SCHLOSSMANN, K.: Agglutinating factor for sensitized

sheep erythrocytes in serum and joint fluid from patients withrheumatoid arthritis, 377

SWANSON, J. N., see DUTHIE, J. J. R., and SWANSON. J. N.SYLVESTER, O., and HVID-HANSEN, N.: Investigations of creatine

excretion in urine of 38 untreated ambulant male patients withfibrositis, and in two healthy men, 241

Synovial fluid, theories regarding origin of, 150Synovial membrane:

permeability of human, effect of hyaluronidase and various steroidhormones on, and clinical restults with artisone (D. R. Fitch andothers), 403

some observations in normal and arthritic human joints (Maunselland others), 363

Synovial mucin, origin of (G Asboc-Hansen), 149

TALBOT, T. R., Jr., see PEARSON, 0. H., ELIEL, L. P., and TALBOT.T. R., Jr.

Temperature measurement, intra-articular. use of, in evaluation ofanti-arthritic agents (J. L. Hollander and others), 401

Tendon lesions in rheumatoid arthritis (J. H. Kellgren and J. Ball). 48Testosterone in rheumatoid arthritis (W. K. Ishmael and others), 406Thorax in ankylosing spondylitis (F. D. Hart and others). 116TRAEGER, C. H., see FREYBERG, R. H., PATTERSON, M., ADAMS, C. H..DURIVAGE, J., and TRAEGER, C. H.

Vascular lesion observed in rheumatoid arthritis (J. J. Bunim andothers), 388

VAN WAGTENDONK, W. J., see LANSBURY, J., SMITH, L. W., WULZEN,R., and VAN WAGTENDONK. W. J.

VAUGHN, J. H., FAVOUR, C. B., and BAYLES. T. B.: Effects of ACTHon complement, gamma globulin, and fibrinogen in rheumatoidarthritis. scleroderma, and lupus erythematosus disseminatus. 399

WALLIS. A. D.: Theory of pathogenesis of rhetlmatoid arthritis, 331WALTHARD, K. M.: Statement at W.H.O. Third Assembly, 255WARREN, J. E., see MASSELL, B. F., and WARREN, J. E.WARTER, P. J., see FITCH, D. R., WARTER. P. J., SEIFTER, J..

JALLO, S., and CORN, 0.

WILENS, S. L., see BUNIM, J. J., SOKOLOFF, L.. and WILENS, S. L.World Health Organization: Third Assembly, 255WRIGLEY, F.: Glycine in treatment of gout, 38

see MAUNSELL, K., WRIGLEY, F., HIGHTON, T. C., and HOLT, L. B.WULZEN, R., see LANSBURY, J., SMITH, L. W., WULZEN, R., andVAN WAGTENDONK, W.

442

INDEX

INDEX TO SUBJECTS OF ARTICLESABSTRACTED

21-Acetoxyypregnenolone, anti-arthritic effect of, 199Acetyl-salicyclic acid in treatment of rheumatic disease, 192Acid, intra-articular injection of, in osteo-arthritis, 188Acromion, excision of, in treatment of supraspinatus syndrome, 193ACTH:

arthritis, chronic, in, 202chronic rheumatism, in, 437effects of, 274eosinophils, effect of, on circulating, 273gout, acute, and rheumatoid arthritis in: relief of symptoms, 198haematological changes in case of rheumatoid arthritis treated

with, 202iritis, recurrent, and episcleritis on a rheumatic basis treated

with, 434lupus erythematosus, disseminated, in, 272neuromuscular function and, in patients with myasthenia gravis,

204peptides in rheumatoid arthritis, 273peritonitis, occurrence during administration of, 436polyarthritis, chronic, treatment of, 272refractory state to, development of, 272rheumatic fever and acute carditis: clinical response to, 419rheumatism, chronic, in, 432rheumatoid arthritis in, 201rheumatoid arthritis, chronic, in, 205rheumatoid arthritis in: attempts to reproduce effects of ACTH

or compound E by other hormones and steroids, 435rheumatoid arthritis in, biochemical and clinical studies, during

administration of, 434rheumatoid arthritis in, compared with intra-muscular adrena-

line and with deoxycortone and ascorbic acid, 435rheumatoid arthritis in, prolonged treatment, 203Thorn's test, and therapeutic effect in rheumatoid arthritis, 200tool of clinical and laboratory research, 203activity, screening test of chemical compounds for, 199

ACTH and cortisone:effect on rheumatic fever, 418acetate effects on rheumatoid arthritis, rheumatic fever, and other

conditions, 431ACTH and insulin hypoglycaemia in, 432Adrenocorticotropin:

and production of gouty arthritis, 92, 269remission of disseminated lupus erythematosus, 192

Adrenal cortex:in pathogenesis of arthritis, 200influence of on body water distribution and renal function, 434

Adrenal cortical hormones: a probable precursor of. Serumcholesterol, 433

Adrenal extract, total, in rheumatoid arthritis, 421Adrenaline:

intramuscular, compared with ACTH in rheumatoid arthritis,435

stimulation in chronic arthritis, 202Allergic:

diseases, suprarenal cortex, in, 271phenomena, 267

Allergy, relations of rheumatoid arthritis and rheumatic fever to, 437Amidopyrine in chronic articular rheumatism, 268p-aminobenzoic acid in chronic joint disease, 94Amyloidosis in rheumatoid arthritis, 422" Anathion ", arthritis in, 427Anemia in pituitary insufficiency, 273Antiarthritic effect of 21-acetoxypregnenolone, 199Antirheumatic activity of ascorbic acid, 417Arthralgia, hepatitis, as cause of, 267Arthritic:

hand, reconstruction of deformed, 428subjects and physical therapy procedures, 191

Arthritis:" anathion " in, 427adrenal cortex in pathogenesis of, 200chronic, certain hormone effects in, 202chronic, sensory denervation of hip, 265clinical, and aureomycin, 190gonococcal, 95gonorrheal, treatment with penicillin, 190gouty, adrenocorticotropin and, 92, 269

Arthritis-continued:gouty, diversity of, and its complications, 197hepatitis as cause of, 267pituitary insufficiency in, 273procaine in, 191sheep-cell, differential, agglutination test in, 438syndrome characterized by glomerulonephritis and, 429

Arthrodesis:of hip joint, 426ischio-femoral, in hip disease, 425spinal, new technique by lateral paravertebral approach, 426

Arthroplasty:of knee, 93vitallium cup, 264, 424

Arthrosis, temporo-mandibular, 264Ascorbic acid:

rheumatic fever, in, 417and deoxycortone, rheumatoid arthritis, in, 199, 202, 271, 433compared with ACTH in rheumatoid arthritis, 435versus adrenocorticotrophic hormones in rheumatoid arthritis.202

Aureomycin:brucellosis in, 426experimental polyarthritis in, with trials in clinical arthritis, 190in vivo action of, on pleuro-pneumonia-like organisms associated

with various rheumatic diseases, 207

Back, low, pain and subfascial fat abnormalities, 431BAL, acute ulcerative buccal Lichen Planus and, 89Baths, contrast, effect of, on peripheral circulation in rheumatoid

arthritis, 423Blood:

plasma from patients with acute disseminated lupus erythe-matosus, 208

serum, human, total plasmin and trypsin inhibitor of, 86values in rheumatoid arthritis. 186

Body water distribution and renal function, influence of adrenalcortex on, 434

Bone:fibrous dysplasia of, 268marrow elements from patients with acute disseminated lupus

erythematosus, 208Brachial neuralgia, 428Brucellosis:

aureomycin and dihydrostreptomycin in, 426cervical spondylits in, 425

Calcification:left atrial, in rheumatic heart disease, 87spinal cord injury, and, 89supraspinatus tendon, of, 193

Calcium succinate and acetyl-salicyclic acid in rheumatic disease. 192Cardiac:

complications in rheumatic fever, 420decompensation, qualitative and quantitative definition of cationsand anions in, 417

lesions in rheumatoid arthritis, 422lesions in serum disease, 418

Carditis, acute, response of, to ACTH, 419Q-T interval in, 183

Central nervous system, rheumatic fever and, 87Childhood:

rheumatic infection in, 88rheumatic and pseudo-rheumatic pain in, 419

Children:rheumatic fever, oral penicillin for. 184ultraviolet blood irradiation therapy in rheumatic fever in, 417

Cholinesterase in allergic phenomena, 267Chrysotherapy in rheumatoid arthritis, 89Colitis, segmental, associated with rheumatic fever, 183Compound E:

attempts to reproduce effects of, in rheumatoid arthritis by otherhormones and steroids, 435

in rheumatoid arthritis, anterior pituitary implantation as ameans of supplying, 201

Copper morrhuate, treatment with, in rheumatoid arthritis, 263

443

ANNALS OF THE RHEUMATIC DISEASESCopper salts in rheumatoid arthritis, 422Coronary occlusion and myocardial infarction associated with chronic

rheumatic heart disease, 183Cortisone:

changes in mice produced by excessive doses of. 273effect of, on production of granulation tissue in the rabbit, 199acetate and pituitary ACTH, effects on rheumatoid arthritis,

rheumatic fever and other conditions, 431acetate, effects of, on rheumatoid arthritis, 203and ACTH, effect of, on rheumatic fever, 418

Cramp in cases of prolapsed intervertebral disc, 196Curare, in treatment of muscle spasm in rheumatic disorders, 192

Deformities of extremities due to intrathoracic disease, 427Deoxycortone in rheumatoid arthritis, 199, 202, 271, 421, 422, 433,

435Desoxycorticosterone:

experimental vascular diseases due to, 199lesions produced experimentally by, 198

Diathermy, microwave, and peripheral circulation, 95Dihydrostreptomycin and aureomycin in brucellosis, 426Disks:

contralateral recurrent herniated, 431prolapsed, 91, 92

Dysphagia, Felty's syndrome in, 263Dysplasia, fibrous, of bone, 268Dystonia, torsion, 182

Edema, electrolyte partition in, 417Elbow, solitary loose bodies in septal region of, 428Electrolyte partition in edema of various origins, 417Endocarditis, subacute bacterial, and rheumatic disease, 86Enzyme systems, mucotytic, 183Eosinophil count, effect of insulin hypoglycaemia on circulating, 436Epinephrine:

effect of, on pituitary-adreno-cortical system, 438in rheumatoid arthritis, 432

Episcleritis, recurrent iritis and. on rheumatic basis, treated withACTH, 434

Eye and joint diseases, concurrent, 94

Felty's syndrome, 186, 263Fever therapy in gonococcal arthritis, 95Fibro-fatty tissue and its relation to certain " rheumatic " syn-dromes, 198

Fluorosis, 266

Glomerulonephritis, syndrome characterized by arthritis and, 429Gold:

salts, rheumatoid arthritis in, 186stomatitis, 89

Gonococcal arthritis, 95Gonorrheal arthritis, 190Gout:

acute, relief of symptoms by ACTH, 198heredity of, and its relationship to familial hyperuricemia, 197liver function and serum protein structure in, 197

Gouty arthritis:adrenocorticotropin, and, 92, 269diversity of, and its complications, 197

Granulation tissue in the rabbit, effect of cortisone on, 199Granuloma annulare and necrobiotic nodules of rheumatoid arthritis,

93

Hallervorden-Spatz disease, 182Haematological changes in rheumatoid arthritis treated with ACTH,

202Headache, 270Heberden's nodes, 89, 188Hemagglutination test, rheumatoid arthritis in, 206Hemangioma, knee joint, of, 268Heparin:

acute articular rheumatism in, 85antiexudative action of, in acute rheumatism, 184tolerance in rheumatic fever, 183

Hepatitis, infectious, in arthralgia and arthritis, 267Hernias, lumbar fatty, 198Hip:

disease, ischio-femoral arthrodesis in, 425procaine injection in, 265sensory denervation of, 265

Hip joint:arthrodesis of, 426arthroplasty of, 264degenerative osteoarthritis. 89osteoarthritis of, 424rhizotomy in, 265

Histamine in allergic phenomena, 267Hormone, certain effects in chronic arthritis, 202Hormones, anterior pituitary and chronic rheumatism, 205Humerus, significance of radiographic changes in upper end of painful

shoulder, 194Hyaluronidase:

action on permeability of human skin, 268mucinous infiltration of skin, 274myxedema, in, 274serologic response to streptococcal hemolysin and, in rheumatic

infection, 437Hydatid disease of vertebrae, 266Hyperuricemia, familial, heredity of gout and its relationship to, 197Hypersensitivity reactions, effect of sodium salicylate in, 267Hypophysis in rheumatoid arthritis, 432

Infancy, Milkman's syndrome in, 428Insulin hypoglycaemia:

effect of, on circulating eosinophil count, 436in chronic rheumatism, 432

Intervertebral disk:herniation of, 269lumbar protrtided, 91prolapsed, 91, 92, 196protrusion, 90)ruptured in 32 operations for sciatica, failure to disclose, 196

Intrathoracic disease, treatment ot deformities of extremities dueto, 427

Iritis, recurrent, and episcleritis on rheumatic basis treated withACTH, 434

Joint disease:chronic, 94eye disease concurrent with, 94of fingers, and menopause, 188

Joints, function of, and rheumatoid arthritis, 88

Knee:arthroplasty of, 93synovial membrane, 93

Knee joint:hemangioma of, 268partial synovectomy of, 194

Lauron " in rheumatoid arthritis, 89Leucopenia, 186Libman-Sacks disease with predominantly renal involvement, 429Liver function in gout, 197Lumbar:

disc degeneration, 197fatty hernias, 198

Lung in rheumatic fever, 87Lupus crythematosus:

acute disseminated, 426use of bone marrow elements and blood plasma from patients

with, 208chronic, peripheral blood flow in, 192disseminated, adrenocorticotropin, and, 192, 272L.E. cell phenomenon, production in vitro, 208malignant, 94

Lymph nodes, 186

Marginal lipping, osteo-arthritis in, 424Menopause and degenerative joint disease of fingers, 188Milkman's syndrome in infancy, 428Mucinoses, 267Mucinous infiltration of skin, hyaluronidase in, 274Mucolytic enzyme systems, 183Muscle spasm in rheumatic disorders, curare in, 192Myasthenia gravis, effects of ACTH on neuromuscular function in, 204

Myocardial infarction associated with cbronic rheumatic heart

disease, 183Myocarditis, induced, in rabbits, 261Myxedema, hyaluronidase, in, 274

Neuralgia, brachial, 428Neuritis, root, and sciatica, 196Neuromusculoskeletal disorders, chronic. intravenous procaine as

analgesic and therapetitic procedure in painful, 193Nodules:

necrobiotic, in rheumatoid arthritis, 93subcutaneous, artificially induced in rheumatic fever patients, 419

subcutaneous, of chronic rheumatoid arthritis, 88

Oedema, see edemaOestrogens, post-menopausal osteoporosis, in, 271

444

INDEXOssification, pathological, and spinal-cord injury, 89Osteo-arthritis:

degenerative of the hip-joint. 89of hip joint, treatment by vitallium-cup arthroplasty, 424of hip joint, oblique displacement osteotomy for, 424histogenesis of, 424intra-articular injection of acid in, 188sacro-iliac, 188trapeziometacarpal joint, 265

Osteoclastoma, malignant, 95Osteoid osteoma. 429Osteoma, osteoid, 429Osteoporosis, post-menopausal, 27111-oxycorticosteroids, excretion of, in paraplegic and rheumatoid

arthritic patients, 433

Paget's osteitis deformans and malignant osteoclastoma, 95Pain:

charts, 95low back, and subfascial fat abnormalities, 431rheumatic and pseudo-rheumatic, in childhood, 419shoulder, 193

Parathyroidectomy in chronic spondylarthritis, 265Pathological tests in rheumatic disease, 207Penicillin, gonococcal arthritis, in, 95Penicillin, oral:

children with rheumatic fever, 184gonorrheal arthritis in, 190prophylaxis in rheumatic fever, 184, 260prophylaxis of streptococcal infection and rheumatic relapse, 417

Periarteritis nodosa, 266Periarthritis. scapulo-humeral of rheumatic origin, 92Peripheral blood flow in chronic lupus erythematosus, 192Peripheral circulation and microwave diathermy, 95Peritonitis, occurrence of, in ACTH administration, 436Physical therapy procedures and intra-articular temperature of normaland arthritic subjects, 191

Pituitary-adrenal:reactivity, study of. by Thorn test, 435function, relation of, to rheumatic disease, 204

Pituitary-adrenocortical system, effect of epinephrine on the, 438Pituitary:

anterior, implantation in cbronic arthritis, 202anterior, implantation as a means of supplying compound E iniheumatoid arthritis, 201

insufficiency, anemia and arthritis in, 273hormones, anterior, chronic rheumatism, and, 205tissue, transplantation of, 273

Plasma viscosity in pulmonary tuberculosis and rheumatic diseases,207

Pleuro-pneumonia-like organisms in rheumatic diseases, atureomycinin, 207

Polyarthritis:aureomycin in, 190chronic, 186chronic, streptococcus agglutination in, 422

Pregnenolone in rheumatoid arthritis, 432A-5-pregrnenolone in rheumatoid arthritis, 421Procaine:

guide to treatment in early assessment of supraspinatus tears, 193injection into hip, 265intravenous, as analgesic and therapeutic procedure in painful

chronic neuromusculoskeletal disorders, 193intravenous use of, in management of arthritis, 191

Progesterone:anhydrohydroxyprogesterone, and, in rheumatoid arthritis, 433chronic arthritis, in, 202rheumatoid arthritis, in, 199

Prostatic rheumatism, senile, 191Protein, C-reactive, in blood and disease process in acute rheumatic

fever, 437Psoriasis, peroral administration of undecylenic acid in, 190Psychogenic rheumatism, 190Pulmonary:

disease manifestations of ankylosing spondylartharitis, 189lesions in rheumatoid arthritis, 89tuberculosis, plasma viscosity in, 207

Q-T interval:acute rheumatic carditis in, 183rheumatic fever in, 418

Rheumatic carditis, acute, Q-T interval in, 183Rheumatic disease:

calcium succinate and acetyl-salicyclic acid in, 192in vivo action of aureomycin on pleuro-pnetimonia-like organisms

associated with, 207

445Rheumatic disease-continued:

pathological tests in, 207pituitary-adrenal function in relation to, 204pulmonary tuberculosis and, plasma viscosity in, 207subacute bacterial endocarditis and, 86tendon sheath involvement in, 190

Rheumatic:disorders, use of curare in muscle spasm of, 192encephalitis, torsion dystonia and Hallervorden-Spatz disease.

182Rheumatic fever:

ACTH and cortisone in, 418activity of rheumatic process in, 260acute, disease process in, and C-reactive protein in blood,

437ascorbic acid in, 417cardiac complications in, 420children, in: ultraviolet blood irradiation therapy in, 417clinical response to ACTH, 419cortisone acetate and pituitary ACTH in, 431haemolytic streptococcus in relation to, 86heparin tolerance in, 183infections of central nervous system in, 87lung in, 87management of, 420 bisnon-specific hyaluronidase inhibitor in, 183pathogenesis, 182penicillin in, 85penicillin, oral, for children with, 184penicillin, oral, in prophylaxis of recurrent, 184, 260prevention of, 417Q-T interval in, 418rheumatoid arthritis and, relations to allergy, 437salicylate action in, 261segmental colitis associated with, 183serological studies in, 184subeutaneous nodules artificially induced in, 419sulphanilamide, prophylactic, in, 182sulphanilamide prophylaxis in, 85tonsillectomy in, 85total plasmin and trypsin inhibitor in streptococcal diseases, 86

Rheumatic heart disease:chronic, associated with coronary occlusion and myocardial

infarction, 183left atrial calcification in, 87

Rheumatic infection in childhood, 88Rheumatic-like lesions in rabbits, induction of, by focal infections-

with Group A streptococci, 418Rheumatic manifestations, suprarenal cortex in genesis of, 198Rheumatic and pseudo-rheumatic pain in childhood, 419Rheumatic and streptoccocal infection, serologic response to strepto-

coccal haemolysin and hyaluronidase in, 437Rheumatic state, the " phase" reaction and the dection of auto-

antibodies in, 184Rheumatic " syndromes, fibro-fatty tissue and its relation tocertain, 198

Rheumatism:acute, anti-exudative action of heparin in, 184acute, the anti-exudative action of heparin in, 184chronic articular, intravenous amidopyrine in, 268acute articular, heparin in, 85chronic, ACTH and insulin hypoglycaemia in treatment of, 432chronic, and anterior pituitary hormones, 205juvenile, after-history of, 87psychogenic, 190senile prostatic, 191

Rheumatoid arthritis:ACTH in, 198, 201, 203ACTH in, compared with intramuscular adrenaline and with

deoxycortone and ascorbic acid, 435ACTH peptides in, 273aetiology, 186, 421amyloidosis in, 422anterior pituitary implantation as means of supplying com-

pound E in, 201attempts to reproduce effects of ACTH or compound E in, by

other hormones and steroids, 435biochemical and clinical studies in, during administration ofACTH, 434

cardiac lesions in, 422chronic, ACTH in, 205chrysotherapy in, 89clinical features, 421copper morrhuate in, 263copper salts in, 422cortisone acetate in, 203cortisone acetate and pituitary ACTH in, 431

ANNALS OF THE RHEUMATIC DISEASESRheumatic arthritis-continued:

contrast baths, effect of, on peripheral circulation in, 422

deoxycortone and ascorbic acid in treatment of, 199, 202, 422, 433deoxycortone with ascorbic acid versus adrenacorticotrophichormone in, 202

deoxycortone and total adrenal extract in treatment of, 421deoxycortone and vitamin C, 422epinephrine, pregnenolone and testoterone in, 432excretion of 11-oxycorticosteroids in paraplegic and rheumatoid

arthritic patients, 433function of joints and, 88gold salts, and, 186haematological changes in, treated with ACTH, 202hypophysis in, 432intensive chrysotherapy (with Lauron) in, 89modification of hemagglutination test for, 206nodules of. 93pituitary implantation in, 272A-5-pregnenolone in, 421progesterone in, 199progesterone and anhydro-hydroxyprogesterone in, 433pulmonary lesions in, 89rheumatic fever and relations to allergy, 437serum protein in, 206sheep-cell agglutination test in, 93steroid therapy in, 200, 201, 422, 434striated muscle, histologic lesions of, in, 263subcutaneous nodules of, 88synovial biopsy in, 206therapeutic criteria in, 89ventricular function and blood values in, 186

Rhizotomy in hip joint, 265

Salicylate, acute rheumatic fever in, 261Sarcoidosis, osseous lesions of, 95Sacro-iliac osteo-arthritis, treatment of, 188Sciatic nerve, dilatation of veins of, 92Sciatica:

failure to disclose ruptured intervertebral disks in 32 operationsfor, 196

inter-myolaminar approach, 92non-mutilating techniques in surgical treatment, 92root neuritis and, 196

Serologic response to streptococcal hemolysin and hyaluronidase instreptococcal and rheumatic infection, 437

Serological studies in rheumatic fever, 184Serum:

cholesterol. A probable precursor of adrenal cortical hormones,433

protein in gout, 197proteins in rheumatoid arthritis, 206

Sheep-cell agglutination test in rheumatoid arthritis, 93, 438Shoulder:

" frozen ", 193painful, 191, 193, 194

Skin, hyaluronidase, action of on permeability of human, 268Sodium salicylate:

hypersensitivity reactions, in, 267myocarditis in rabbits, induced, in, 261

Spinal-cord injury and spondylitis, 89Spleen and lymph nodes, enlargement of, 186Spondylarthritis:

ankylosing, pulmonary disease in, 189chronic, treatment by parathyroidectomy, 265

Spondylitis:89ankylosing, statistical studies in, 90cervical, in brucellosis, 425rheumatoid, 90spinal-cord injury, and, 89

Steroid:compounds, effect on various manifestations of rheumatoid

arthritis, 201therapy in rheumatoid arthritis, 422, 434

Steroids, actions of various, in rheumatoid arthritis, 200Stomatitis, gold, 89Streptococcal:

rheumatic infection, and, serologic response to streptococcalhemolysin and hyaluronidase in, 437

infection, and rheumatic relapse, oral penicillin in, 417infection, treatment of, in prevention of rheumatic fever, 417

Streptococci:Group A, focal infections with, inducing rheumatic-like lesions

in rabbits, 418haemolytic, infections related to rheumatic fever, 87

Streptococcus:agglutination in chronic polyarthritis, 422haemolytic, relation to rheumatic fever, 86

Stress, adrenocorticotrophic effect of, 273Subfascial fat abnormalities and low back pain, 429Sulfonamides in gonococcal arthritis, 95Sulphanilamide:

prophylactic, in rheumatic fever, 182prophylaxis in rhzumatic fever, 85

Suprarenal cortex:allergic diseases, in, 271genesis of rheumatic manifestations, in, 198

Supraspinatus:syndrome, excision of acromion in treatment of, 193tears, early assessment. Procaine as guide to treatment, 193tendinitis of, 191tendon, calcification of. Painful shoulder, 193

Synovectomy, partial, of knee joint, 194Synovial:

biopsy in rheumatoid and rheumatic arthritis, 206membrane of knee, 93

Synovitis, pigmented villonodular, 426

Temporomandibular joint, method of mobilizing, 425Tendon-sheath involvement in rheumatic diseases, 190Testosterone:

chronic arthritis, in, 202rheumatoid atsthritis, in, 432

Therapeutic criteria in rheumatoid arthritis, 89Thorn test, 200, 435Tissue temperature and microwave diathermy, 95Tomogtam, vertebral, 90Tonsillectomy in rheumatic fever, 85Tonsillitis acute, antistreptolysin titre in, 182Trapezium, excision of, 265Tuberculosis, pulmonary, and rheumatic diseases, plasma viscosity

in, 207d-Tubocurarine in rheumatoid spondylitis, 90

Ultraviolet blood irradiation therapy (Knott technique) in rheumatic

fever in children, 417Undecylenic acid in psoriasis, 190

Vascular diseases, experimental, due to desoxycorticosterone acetate

and anterior pituitary extract, 199Ventricular function in rheumatoid arthritis, 186Vertebrae, hydatid disease of, 266Vertebral:

disease, tomography of, 90tomogram, 90

Vitamin C and deoxycortone in rheumatoid arthritis, 422

Weltmann serocoagulation reaction in rheumatic fever, 260

446

INDEX

INDEX TO AUTHORS OF ARTICLESABSTRACTED

Abaza, A.. 188Abrahams, D. G., 183Abramson, D., 89Alexander, W. A. M., 199Alimurung, M. M., 418Amsterdam, S. D., 184Anderson, H. C., 437Anderson, I. A., 271Andreola, E., 94De Anquin, C. E., 191Antopol, W., 273Appelgren, A., 186Armstrong, J. R., 193Arreche, C. C., 184Asboe-Hansen, G., 268, 418Ash, R., 88Astrup, P., 418

Bachrach, S., 421Baggenstoss, A. H., 429Bailey, R. L., 85Bariety, M., 427Batterman, R. C., 89Beard, E. E., 188Beare, J. M., 94Beck, J. C., 436Benda, C. E., 182Berglund, G., 91Berglund, K., 434Berson, S. A., 432Bertrand, L., 425Bickel, W. H., 424Bishop, L. F., 422Bayles, T. B., 204Black, J. B., 85Bland. E. F., 418Bloom, D., 274Blunt, J. W., 199Bogdanyan, M. G.. 86Boland, E. W., 203Boni, A., 186Boots, R. H., 201Bowers, R. E., 93Brainerd, H. D., 87Brieu, A., 435Brink, W. R., 417Br0chner-Mortensen, K., 205,418

Brown, J. T., 193Brown, T. McP., 207Browne, J. S. L., 436Brownlee, G., 271Briigger, Y., 200Brunner, M. J., 267Bunim, J. J., 263Bywaters, E. C. L., 420, 433

Caplan, P. S., 192, 269Cavallaro, W. U., 426Cecil, R. L., 432Certonciny, A., 422&ervenansky, J., 265Chartrain, E., 85Cheng, C. P., 273Coen, W. B., 419Coggcshall, H. C., 93Cohn, C., 197Cohn, I1., 433Cohn, P. D., 85Coke, H., 207Collins. D. H., 207Combes, F. C., 192Conn, J. W., 433Copeman, W. S. C., 198Corcoran, A. C., 199

Corvilain, J., 432, 436Coster, C., 422Coury, C., 427Cowan, I. C., 207Craige, E., 418, 419Crain, D. C., 433Cuatrecasas, J., 205Currie, J. P., 422Custer, E. A., 417

Dahlberg. G., 88Dammercr, W. H., 432Daugherty, G. W., 429Davidson, R., 263Dawson, J. E., 207Della Santa, R., 200Denny, F. W., 417Derennes, R., 265Desmarais, M. H. L., 207Dittrich, R. J., 431Dixon, A. St. J., 433Diian, A., 90Dordick, J. R., 438Donzelot, E., 85, 184Dowling, H. F., 95Dresner, E., 435Duckett Jones, T., 419Duffy, M., 201Dunning, P. M., 417Duthie, J. J. R., 199

Echols, D. H., 196Edstrom, G., 202, 272Ekvall, S., 196Elkington, J. R., 274Empire Rheum. Council Sci.

Advisory Ctte, 421Engel, J. P., 423Epstein, B. S., 87Ergenbright, W. V., 265Erickson, D. J., 422Eriksson-Lihr, Z., 271Etinger, Y. G., 86von Euler, U. S., 273Evans, J. A. P., 417Ewerbeck, H., 428

Faber, V., 418Fabre, J., 200Fahndrich, W. H., 268Fahrni, W. H., 424Fairley, D. M., 190Fajans, S. S., 433Farnsworth, E. B., 417Fellinger, K., 201Fernandez Yruecas, D., 425Fischel, E. E., 184Fitch, D. R., 199Foged, J., 264Forestier, J., 90, 422Forsham, P. H., 204, 438Forssell, P., 271Fortier, C., 273Freeman, H., 421Friberg, S., 197Friedman, H. H., 89Friedman, S., 86Friou, G. J., 85

Gabrielson, L. G.. 263Garcia Dfaz, F., 425Gardner, F. E., 183Gardner, G. M., 190Gaudino, M., 434Georg. J., 205

Gersten, J. W., 95Gervis, W. H., 265Gibson, A., 264Gibson. H. J., 207Gil, J. R., 200Giunchi, G., 436Glick, D., 183Glynn, L. E., 183Godfrey, L., 274Godtfredsen, E., 94Gonzalez, R. E., 87Good, R. A., 183Goodman, L. S., 273Gordon, G. L., 272Graber-Duvernay, J., 263Grace, A. W., 192Graettinger, J. S.. 85Grais, M. L., 274Graubard, D. J., 191Greenfield, M. M., 426Grokoest, A. W., 201Guest, C. M., 432Guillaume, J.. 92

Hai-Peng Lei, 266Hakanson, E. Y., 434Hall, B., 419Hamilton, K. A., 189Hanburger, C., 205, 418Hao Li, C., 273Haour, P., 198Hargraves, M. M., 207Harkness, J., 207Harris, T. M., 437Harris, T. N., 86Harris, S., 437Harrison, S. H., 194H,avermark, N. G., 202, 434Headley, N. E., 203Hellbaum, A., 201Heller, G., 206Hellman, L.. 92Hench, P. S., 422, 431Herlin, L., 265Herrick, J. F., 95Herrmann, F. J., 274Hersh, A. H., 188,197Hershfield, B. M., 183Hill, S. R., 204Hirsch, C., 197Hirsh, H. L., 95Hiort, A. M., 267Hofer, J. W., 184Hofmann, A., 91Hogle, J., 267Hollander, J. L., 191Holmes, M. C., 182Holt, J. F., 95Hornicky, P., 265Hortling, H., 273Horvath, S. M., 191Horwitz, M., 88Houston, J., 207Howes, E. L., 199Horwitz, T., 89Huff, S. E., 192Hume, D. M.. 438Humphrey, J. H., 267Hunt, A. D., 274Hunt, H. D., 197Hyman, I., 265

lshmael, W. K., 201

Jacobs, J. E., 268Jacobson, A. S.. 206

447

448Jacqueline, F., 90, 422Janbon, M., 425J8rvinen, K. A. J., 437Jeffrey, M. R.. 422Jennings, G. H., 422Johnson, C. W., 421Johnson, L. G., 436Jones, G. B., 193Jonsson, E., 434Junkersdorf, J., 268Jurmand, S. H., 92

Kaldegg, A., 190Kalmon, E. H., 268Kamberg, S.. 89Kaufmann, H., 85, 184Kelikian, H., 425Kendall, E. C., 431Kennedy, A. F., 192Kennedy, B. J., 436Kersley, G. D., 422, 434Kestler, 0. C., 428Keys, A., 192Kilborn, L. G., 266King, B. G., 266Klemola, E., 267Koets, P., 263Kohn, K. H., 260Kolodny, M. H., 206Krakusin, J. S.' 417Krusen, F. H., 95, 423Kuhn, J. F., 201Kuzell, W. C., 190Kyle, L. H., 433Ladehoff, A., 188Lago, H. D., 198Lambert, P. P., 432Larizza, P., 186Lasserre, C., 265Laurell, H., 434Lee, F. W., 268Lehmus, H. J.. 417Le Vay, D., 202Levine, R., 197Levitt, M. F., 434Lewey, F. H., 90Lewin, E., 199Leys, D. G., 89Libenson, L., 427Lindeboom, G. A., 263Lockie, L. M., 90, 265Louis, L. H., 433Lowry, F. C., 265Loxton, G. E., 202Luft, R., 273

McCabe, G. E., 421McCarty, M., 437McCrory, W. W., 274McEwen, C., 263MacGilpin, H., 421MacGregor, A. G., 261Mach, R. S., 200MacKenzie, D. W., 436MacLean, H., 260McSwain, B., 268de Maeyer, E., 202Magnusson, R., 193Maliner, M. M., 184Malmros, H., 182Mandel, L., 422, 434Mann, W. A., 434Mantha, L., 186Margolis, H. M., 192, 269Margorin. E. M., 91Marks, D. N.. 183Markson, D. E., 203, 434Marton, R., 193Masseboeuf, A., 92Massell, B. F., 204, 417, 418,419

Masson, G. M. C., 199Mazars, G., 92Menthe, J. W., 433Merchant, W. R., 207Michez, J., 191Milberg, I. L., 190Milch, E., 265

ANNALS OF THE RHEUMATIC DISEASESMiley, G. P., 417Milzer, A., 260Mont, F. G., 200van Moorleghem, G., 263Mordant,-., 89Murphy, G. E., 418

Nelson, H. G., 85, 260Nelson. S. S.. 433Niedermeier, W., 202Norcross, B. M., 90Nordenson, N. G., 202Nory, J., 85Nystrom, G., 435

Obletz, B. E., 265O'Neill, D., 190Orr, H., 426Osborne, G. V., 424Ott, V. R., 92Outerbridge, T. S., 266Owens, W. I., 95

Page, I. H., 199Palitz, L. L., 267Palmer, H., 95Paraf, J., 188Patterson, P. R., 417Pauli, R. H., 184Pauzat, P., 265Pearse, A. G. E., 432Peretz, E., 188Perlman, H. H., 190Perrault, M., 435Peterson, M. C., 191Pettay, O., 271Philip, W. M., 428Pike, R. M., 93Pincus, G., 421Pino-Saccd, F., 89, 424Pique, J. A., 206Plotz, C. M., 199Poinsard, G., 435Polley, H. F., 431Proffitt, J. N., 268Pugh, L. G. C., 435

Raaf, J., 91Ragan, C., 199, 201Rammelkamp, C. H., 417Recant, L., 438Rehfeldt, F. C., 196Reid, J., 261Rescanieres, A., 428Robecchi, A., 89, 424Robins, H. M., 90Robinson, J. A.. 95Robinson L. B., 207Robles, Gil J,- 419Rogerson, A. G., 274Rosenberg, E. F., 197, 422Rotes. J., 90Rotes-Qudrol, J., 269Rothbard, S., 87Rovello, F., 186Rubbo, S. D., 182Rusk, I., 27'Russell, D. S., 95

Salvaing, J., 425Samson, J. E., 93San Josd Caballero, P., 425Sayers, G., 273Schajowicz, F., 206Schlesinger, B., 88Schmerling, M. G., 86Schmidt, S., 429Schmith, K., 418Schwartz, M., 272Seal, J. R., 85, 260Scifter, J., 199Selye, H., 200, 273de S&ze, S., 90, 92, 269Sharlit, H., 274Simmonds, F. A., 193Sjogren, B., 273Slocumb, C. H., 431Smith. S., 204Smith, W., 267

Snow, W. G., 263Snorrason, E., 205Soeur, R., 93Sokolow, M., 87Solokoff, L., 263Solomon, W. M., 197Sonne, L. M., 272Speed, J. S., 93Sperfing, I. L., 190Spies, T. D., 198, 199, 202, 203Spitzer, N., 190, 193Spechler, M., 205, 418Sproull, D. H., 261Staub, P. L., 433Stecher, R. M., 188, 197Steinbrocker, O., 89, 190, 193Stevens, R. W., 270Stinchfield, F. E., 426Stokes, H. L., 182Stokes, J., 274Stokes, L., 85Stone, R. E., 198, 199, 202, 203Sturgis, G. P., 419Sulkin, S. E., 93Sundelin, F.. 88Swift, H. F., 87, 418Swift, P. N., 89Swinyard, C. A., 273

Tagnon, R., 432, 436Talbott, J. H., 197Tarnopolsky, S., 421Taylor, H. L., 192Tegner, W., 190Teneff, S., 426Thorn, G. W., 204, 438Todd, E. W., 86Torda, C., 204Torma, S., 267Traeger, C. H., 89Trout. P. C., 93

Valdes Santurio, E. R., 425Vera, A. R., 198Vermehren, E., 272Vermehren, M., 272Videbaek, 205, 418Vignalov, J., 435Vogel, W. C., 433

Wakim, K. G., 95, 423Wallace, K. M., 426Wallis, A. D., 206Wannamaker, L. W., 417Warren, J. E., 204, 417, 419Warter, P. J., 199Wasserman, M. M., 438Wassen, E., 199Wasson, V. P., 417Watkin, K. G., 95, 423Watson, R. D., 261Watson, R. F., 87Weiderkehr, J., 92Weil, M. P., 90Weintraub, 1t. J., 422White, P. D., 183Whittington, R, B.. 207Wichelhausen, R. H., 207Wilander, O., 182Wild, J. B., 433, 435Wilens, S. L., 263Will, G., 422Wilson, A. T., 87Winblad, S., 182With, T. K., 205Withers, R. J. W., 193Wittenborn, W. F. J., 427Wolf, H. G.. 204Wolfson, W. Q., 197Wolman, L., 196Wood, D. R., 261Wood, P., 420Woodland, L. J., 266Woodroffe Anderson, C.. 87Worden, A. S., 267Wycis, H., 431

Zeller, W. W., 95