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CURRICULUM VITAE DATE: March 17, 2017 NAME: Chen Liu, MD, Ph.D. PRESENT TITLE: Professor and Chairman

Department of Pathology and Laboratory Medicine New Jersey Medical School and Robert Wood Johnson Medical School Rutgers University Chief of Service, NJMS University Hospital and RWJ University Hospital Director of Molecular Pathology, Cancer Institute of New Jersey

OFFICE ADDRESS: Rutgers – New Jersey Medical School 185 South Orange Avenue MSB C 671 Newark, NJ 07103 Rutgers – Robert Wood Johnson Medical School One Robert Wood Johnson Place MEB 212 New Brunswick, NJ 08901 TELEPHONE NUMBER/E-MAIL ADDRESS: 973-972-1241 (Office-NJMS) 732-235- 8120 (Office-RWJ)

Chen.Liu@Rutgers.edu CITIZENSHIP: USA EDUCATION:

A. Undergraduate Graduate and Professional Tong Liao Medical College (Inner Mongolia University of Nationality), Tong Liao, China

Degree (Discipline): B.M./M.D. (Medicine) Date Awarded: July, 1985

B. Graduate and Professional University of Pennsylvania School of Medicine, Philadelphia, PA Degree (Discipline): Ph.D. (Pathology) Date Awarded: December, 1993 POSTGRADUATE TRAINING:

A. Internship and Residencies Hahnemann U. Hospital, Philadelphia, Pennsylvania Anatomical and Clinical Pathology 01/01/1996 to 06/30/1999

MD Anderson Cancer Hospital, Houston, Texas Surgical Oncological Pathology 07/01/1999 to 06/30/2000

B. Research Fellowships Scripps Clinic, La Jolla, California Oncovirology 01/01/1994 to 12/31/1995

C. Postdoctoral Appointments Scripps Clinic, La Jolla, California

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Oncovirology 01/01/1994 to 12/31/1995

ACADEMIC APPOINTMENTS: Department of Pathology and Laboratory Medicine Rutgers - New Jersey Medical School Professor and Chair 2015 – present

Department of Pathology and Laboratory Medicine Rutgers – Robert Wood Johnson Medical School Professor and Chair 2015 to present Department of Pathology and Immunology, Laboratory Medicine University of Florida

Associate Chair 2012 – 2015

Department of Pathology and Immunology, and Laboratory Medicine University of Florida

Professor (Tenured) 2010 – 2015 Department of Pathology, Immunology, and Laboratory Medicine University of Florida

Endowed Chair in Gastrointestinal and Liver Research 2008 – 2015 Department of Pathology, Immunology, and Laboratory Medicine

University of Florida Associate Professor (Tenured)

2006 – 2015 Department of Pathology, Immunology, and Laboratory Medicine University of Florida Assistant Professor 2000 – 2015

HOSPITAL APPOINTMENTS: University Hospital Attending Physician December 2015 – present Robert Wood Johnson University Hospital Attending Physician December 2015 - present University of Florida Shands Hospital Attending Physician July 2000 – November 2015 MD Anderson Cancer Center, University of Texas,

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Clinical Fellow July 1999 – June 2000 MCP Hahnemann University Hospital House Staff January 1996 – June 1999 OTHER EMPLOYMENT OR MAJOR VISITNG APPOINTMENTS: None LICENSURE:

Medical License #ME80099 State of Florida. Expire: Jan 31, 2018 Medical License #25MA09724000 State of New Jersey. Expire: June 30, 2017

DRUG LICENSURE: CDS: N/A DEA: N/A CERTIFICATION:

American Board of Pathology, AP/CP, indefinite (No expiration) MEMBERSHIPS, OFFICES AND COMMITTEE ASSIGNMENTS IN PROFESSIONAL SOCIETIES:

College of American Pathologists (CAP) Lifetime Member 2000 - present

American Association for the Study of Liver Diseases (AASLD) Member and Basic Science Committee 2000 - present Association of Pathology Chairs (APC) Member 2012 - present American Gastroenterology Association (AGA) Member and nomination committee 2000 - present American Society of Investigative Pathology (ASIP) Member 2002 - present United States & Canadian Academy of Pathology (USCAP) Member 2003 - present Hans Popper Hepatopathology Society Member and Educational Committee 2005 - present Rodger Haggitt Gastrointestinal Pathology Society Member 2005 - present International Liver Cancer Association (ILCA)

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Member 2010 - present American Association for Cancer Research (AACR) Member 2009 - present HONORS AND AWARDS:

University of Florida Research Foundation Professorship 2014 Technology Innovator Award, University of Florida 2013 Pathology Resident Teaching Award, University of Florida 2011 Howard Hughes Medical Institute Undergraduate Mentor Award 2010 Mid-career Mentor Award, National Institute of Health 2009 Liver Research Scholar, American Liver Foundation 2002 Clinical Fellow Research Award, M.D. Anderson Cancer Center 1999 Award from Gastrointestinal Pathology Society 1998 House Staff Research Award, MCP Hahnemann University 1997 Individual National Research Award, National Cancer Institute, NIH 1994 Scientific Merit Award, Ministry of Health, China 1988 Honored Outstanding Medical Graduate, Tong Liao Medical College 1985

BOARDS OF DIRECTORS/TRUSTEES POSITIONS: Chair, Board of Trustee, Chinese Hua-Gen School, Gainesville, Florida

2008 – 2011 SERVICE ON NATIONAL GRANT REVIEW PANELS, STUDY SECTIONS, COMMITTEES: Member of National Institutes of Health Study Sections (ad hoc): 2003, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015 NIH Clinical Oncology Study Section (CONC, Chartered Member) 2015-2021

SERVICE ON MAJOR COMMITTEES:

A. International: American Association for the Study of Liver Diseases (AASLD)

Basic Science Committee 2004 - 2008

American Gastroenterology Association (AGA)

Nomination Committee 2011 - 2014

Hans Popper Hepatopathology Society Educational Committee 2010 - 2013

B. National: Annual Princeton Integrated Pathology Symposium (PIPS) Advisory Committee 2013 – Present

Alpha-1 Foundation Member of Tissue Bank Committee, 2005 – 2008.

C. Medical School/University:

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Academic Affair Committee of Faculty Senate University of Florida 2010 – 2014 Rutgers Health I2P2 Committee New Jersey Medical School 2016 – present Financial Committee Robert Wood Johnson Medical School 2016 - present

D. Hospital: IT and LIS Steering Committee University of Florida Shands Hospital 2013 - present

E. Department: University of Florida Department of Pathology, Immunology and Lab Medicine Faculty Search Committee 2011 – present Patient outcome and population research committee 2013 - present

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F. Editorial Boards:

Associate Editor, Laboratory Investigation (USCAP Official Journal) 2010 – Present Editorial Board, Archives of Pathology &Laboratory Medicine

Section Editor: Precision Medicine (College of American Pathologists Official Journal)

2014 – Present

G. AdHoc Reviewer: J. Virology 2002 to present Hepatology 2004 to present Gastroenterology 2006 to present Oncogene 2008 to 2009 American J. Pathology 2004 to present Human Pathology 2010 to present Cancer Research 2010 to 2011 J. Infectious Disease 2012 to 2014 Modern Pathology 2011 to present PlosOne 2013 to present Plos Pathogen 2012 to present

SERVICE ON GRADUATE SCHOOL COMMITTEES: None SERVICE ON HOSPITAL COMMITTEES:

See Service on Major Committees, D. SERVICE TO THE COMMUNITY:

Member of Advisory Board, Eastside High School, Gainesville, Florida 2011 – present

Chair, Board of Trustee, Chinese Hua-Gen School, Gainesville, Florida 2008 – 2011

SPONSORSHIP (Primary Mentorship) OF CANDIDATES FOR POSTGRADUATE DEGREE: Jennifer Bess (Immunology and Microbiology) 2004 – 2009 Erika Eksioglu (Immunology and Microbiology) 2005 – 2010 Thin Le (Immunology and Microbiology) 2010 – 2014 SPONSORSHIP (Primary Mentorship) OF POSTDOCTORAL FELLOWS: Olorunseun Ogunwobi, Ph.D, Postdoctoral fellow 2009 – 2014 Elaine Salazar, M.D., Postdoctoral fellow 2011 – 2012 Hongyan Liu, Ph.D., Postdoctoral fellow 2007 – 2011 Frank Zhao, Ph.D., Postdoctoral fellow 2007 – 2012 Houda Darwiche, Ph.D., Postdoctoral fellow 2009 – 2011 Liping Sun, Ph.D. Postdoctoral fellow 2009 – 2011 Jun Hu, M.D., Postdoctoral fellow 2011 – 2012 Rafal Witak, Ph.D., Postdoctoral fellow 2005 – 2007 John Elyar, Ph.D., Postdoctoral fellow 2003 – 2006 Jane Dong, Ph.D., Postdoctoral fellow 2005 – 2007 Qi Su, M.D., Ph.D., Postdoctoral fellow 2005 – 2006 Kien Pham, Ph.D. Postdoctoral fellow 2013 – present Frank Wu, Ph.D. Postdoctoral fellow 2014 – present Chaohui Zuo, M.D., Postdoctoral fellow 2014 – 2015 William Puszyk, Ph.D., Postdoctoral Fellow 2009 – 2011

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TEACHING RESPONSIBILITIES: A. Lectures or Course Directorships University of Florida Fellowship Director, Gastrointestinal and Liver Pathology 2004 – 2015 Pathology Resident Teaching 2000 – 2015 Teaching Director, Molecular Pathology 2001 – 2008 Course Director, Systemic pathology: GI-Liver section for 2nd year-medical students (40 hrs per year) 2003 – 2010 Mentor, IDP graduate program at the University of Florida 2002 – 2015 Mentor, NIH-T32 training program in Autoimmunity 2005 – 2015 Mentor, NIH-T32 training program in Cancer Biology 2008 – 2013 Lecture Graduate school:

Courses: Liver pathophysiology (10 hrs per year) 2001 – 2012 Mechanisms of Oncogenesis (6 hrs per year) 2009 – 2015

B. Research Training (other than Primary Mentorship) Post Doctoral Fellows: Olorunseun Ogunwobi, Ph.D, 2009 – 2014 Elaine Salazar, M.D., 2011 – 2012 Hongyan Liu, Ph.D., 2007 – 2011 Frank Zhao, Ph.D., 2007 – 2012 Houda Darwiche, Ph.D., 2009 – 2011 Liping Sun, Ph.D. 2009 – 2011 Jun Hu, M.D., 2011 – 2012 Rafal Witak, Ph.D., 2005 – 2007 John Elyar, Ph.D., 2003 – 2006 Jane Dong, Ph.D., 2005 – 2007 Qi Su, M.D., Ph.D., 2005 – 2006 Kien Pham, Ph.D. 2013 – present Frank Wu, Ph.D. 2014 – present Chaohui Zuo, M.D., 2014 – 2015 William Puszyk, Ph.D., 2009 – 2011

Pre Doctoral Students: Jennifer Bess (Immunology and Microbiology) 2004 – 2009 Erika Eksioglu (Immunology and Microbiology) 2005 – 2010 Thin Le (Immunology and Microbiology) 2010 – 2014

CLINICAL RESPONSIBILITIES:

As the Chair of the Department of Pathology and Laboratory Medicine, I oversee the day to day operations of the entire department in both Newark and New Brunswick as well as satellite locations.

As the Chief of Service for Gastrointestinal and Liver Pathology Service at University Hospital in Newark, I provide pathology specialty service, consultation service for patients and clinical practitioners, and administration. As a well-recognized GI/liver pathologist I also provide a large number of expert consultations for many physicians/patients throughout the United States.of Florida and across the US.

GRANT SUPPORT:

A. Principal Investigator

1. R01, National Institute of Health, NCI “Molecular targets for liver cancer diagnosis and therapy” 06/01/2009 – 08/31/2016

2. R01 National Institute of Health, NCI “Developmental pathways, environmental agents, and epigenetics in liver disease”

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09/20/2011 – 07/30/2017

3. James &Ester King Biomedical Research Program "Small molecule inhibitors for Alppha-1 antitrypsin deficient treatment" 05/25/2015 – 05/24/2018 4. University of Florida Research Foundation

Experimental models for human pancreatic cancer 05/01/2014 – 02/28/2016

B. Co-Investigator

1. R01 CA173878, National Institute of Health, Reddy (PI) “Role of noncoding RNA in Regulating GVHD”

03/01/2013-02/28/2018

2. R01 HL125571, National Institute of Health Hanash (PI) “Regulation of the intestinal stem cell compartment after hematopoietic transplantation” 07/01/2015-04/30/2020

3. R01 HL124112, National Institute of Health Jenq (PI) “Microbiota-focused strategies to mitigate GVHD” 08/15/2015-05/31/2020

4. R01 AI118305, National Institute of Health, Yu (PI)

“MicroRNA Regulates Graft-versus-Host Disease” 08/01/2015-01/31/2020

C. Completed

1. National Institute of Health, NCI Co-Investigator "Cellular and Molecular Studies of Bone Marrow Transplants" 07/01/2010 – 04/30/2015

2. National Institute of Health, NIAAA

Co-Investigator “Acute Alcohol and Calcium-Dependent LPS-Triggered Activation of Microphages” 09/01/2009 – 08/31/2014

3. Hamner Institute

Principal Investigator “Hepatic Tissue Registry” 05/01/2014 – 04/30/2017

5. Juvenile Diabetes Research Foundation Co-Investigator “Organ Processing and Pathology Core” 12/01/2006 – 12/31/2017

6. Bayer Testing Group Co-Investigator “Bayer testing services agreement” 02/01/2013 – 12/31/2015

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4. National Institute of Health, NCI Co-Investigator "TH1/TH17 cell differentiation in GVHD and GVL" 06/01/2010 – 04/30/2015

5. American Association for Cancer Research Mentor “Mechanisms of metastasis in pancreatic cancer” 03/01/2012 – 02/28/2014

6. National Institute of Health, NCRR Principal Investigator “Mouse Immunopathology” 04/01/2009 – 12/31/2014

7. National Institute of Health, NIAID Principal Investigator no-cost-extension "Innate and adaptive immune response in HCV patients" 04/01/2005 – 03/31/2011

8. University of Florida Cancer Center Principal Investigator Team Science Project: “Immunotherapy for Liver Cancer” Total 4 projects and 6 project leaders 01/10/2012 – 02/28/2014

9. University of Florida Research Foundation Principal Investigator "Nanozymes in cancer therapy" 07/01/2010 – 06/30/2012

10. National Institute of Health, NHLBI Co-Investigator "Gene Therapy Using Viral Vector for Lung and Cardiovascular Disease" 09/01/2008 – 06/30/2013

11. National Institute of Health, NCI Principal Investigator "TCGA program: Pathogenesis of hepatocellular carcinoma" 09/01/2010 – 08/31/2013

12. National Institute of Health, NIDDK Co-Investigator "Transduction of hepatocytes with rAAV for correction of genetic abnormalities" 08/01/2006 – 07/31/2011

13. UF/Moffitt Cancer Center Principal Investigator “Immunotherapy for liver cancer” 2009 – 2010

14. Florida Legislature 00079010 Principal Investigator "Adaptive Cell Therapy for Liver Cancer Using Bone Marrow Transplantation Platform" 03/01/2009 – 03/31/2011

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15. BANYAN BIOMARKERS, Inc. Co-Investigator " Liver Serodiagnostic Panel of Liver Inflammation and Fibrosis in Patients." 2008 – 2010

16. National Institute of Health, NHLBI Principal Investigator “Small molecules to treat alpha-1 antitrypsin deficiency” 2005 – 2008

17. Alpha-one Foundation Principal Investigator “Therapeutic small molecules for alpha-1 antitrypsin deficiency” 2007 – 2009

18. Geyer Foundation for Cancer Research Principal Investigator “Liver Cancer Biomarkers” 2008 -- 2009

19. National Institute of Health, NIAID Principal Investigator “Murine model for hepatitis C virus” 2005 – 2008

20. National Institute of Health, NIDDK Principal Investigator “Role of liver cytokine expression in hepatitis C viral infection” 2002 – 2007

21. Florida Biomedical Research Program Co-Principal Investigator Biomarker discovery of liver cancer. 2007 – 2008

22. National Institute of Health, NIDDK Principal Investigator “Role of SOCS3 in Interferon Resistance” 2005 – 2008

23. CellzDirect Corporation (Invitrogen Inc.) Principal Investigator “Hepatic Registry Program.” 2005 – 2007

24. Howard Hughes Medical Institute Principal Investigator Startup Program 2000 – 2002

25. Howard Hughes Medical Institute Principal Investigator Pilot Project 2000 – 2003

26. University of Florida Research Foundation Principal Investigator

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Opportunity research fund 2002 – 2003

27. American Liver Foundation Principal Investigator “Establishment and characterization of PiZZ liver cell lines.” 2003 – 2005

28. American Liver Foundation Principal Investigator Liver scholar award 2002 – 2005

29. Children’s Miracle Network Principal Investigator “Novel treatment for hepatoblastoma.” 2005 – 2006

30. Wyeth Research Co-Investigator "A Randomized, Open-Label, Comparative Evaluation of Conversion From Calcineurin Inhibitor Treatment To Sirolimus Treatment Versus" 2003 -- 2007

PUBLICATIONS:

A. Refereed Original Article in Journal 1. Liu C, Condreay LD, Burch JB, Mason WS (1991) Characterization of the core

promoter and enhancer of duck hepatits B virus. Virology 184:242-252. PMID: 1871970

2. Mason WS, Cullen J, Saputelli J, Wu TT, Liu C, London WT, Lusterbader E,

Shaffer P, O’connell, Aldrich CE, Jilbert AR (1994) Characterization of the antiviral effects of 2’carbodeoxyguanosine in duck chronically infected with duck hepatitis B virus Hepatology 19:398-411. PMID: 8294097

3. Liu C, Mason WS, Burch JBE (1994) Identification of factor binding sites in duck

hepatitis B virus and in vivo effects of enhancer mutations. Journal of Virology. 68:2286-2296. PMID: 8139013

4. Liu C, Smith BC, Nicolaou BM, Vogt P (1996) Sequence selective carbohydrate

DNA interaction: Dimeric and monomeric forms of the calicheamicin aryltetrasacchride interfere with transcription factor function. Proceeding of National Academy of Science. U.S.A, 93:940-944. PMID: 8570664

5. Guo JT, Liu C, Mason WS, Pugh JC (1998) Cloning and expression of a cDNA encoding the large subunit of duck replication factor C. Biochimica et Biophysica Acta 1395:293-300. PMID: 9512663

6. Ayala G, Liu C, Nicosia R (2000) Microvasculature and VEGF expression in

cartilaginous tumors. Human Pathology. 31:341-346. PMID: 10746677

7. Guo JT, Zhou H, Liu C, Aldrich C, Saputelli J, Whitaker T, Barrasa I, Mason WS, Seeger C. (2000) Viral clearance and hepatocyte turnover during hepatitis B infection in woodchucks. Journal of Virology. 74:1495-1505. PMID: 10627561

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8. Reddy P, Teshima T, Lowler K, Kukuruga M, Liu C, Cooke K, Ferrara J (2001) Interleukin-18 regulates acute graft versus host disease by enhancing Fas mediated donor T cell apoptosis. Journal of Experimental Medicine. 194:1433-1440. PMID: 11714750

9. Teshima T, Liu C, Lowler KP, Dranoff G, Ferrara J. (2002) Donor leukocyte

infusion from immunized donors increases tumor vaccine efficiency after allogenic bone marrow transplantation. Cancer Research. 62:796-800. PMID: 11830535

10. Teshima T, Reddy P, Lowler K, Kukuruga M, Liu C, Cooke K, Ferrara JM (2002)

cells. Blood. 99:1825-1832. PMID: 11861301

11. Ordemann R, Hutchinson R, Friedman J, Burakoff SJ, Reddy P, Duffner U, Braun TM, Liu C, Teshima T, Ferrara J. (2002) Enhanced allostimulatory activity of host antigen-presenting cells in old mice intensifies acute graft-versus-host disease Journal of Clinical Investigation. 109:1249-56. PMID: 11994414

12. Firpi RJ, Abdelmalek MF, Soldevila-Pico C, Reed A, Hemming A, Howard R, Van

Der Werf W, Lauwers G, Liu C, Crawford JM, Davis GL, Nelson DR. Combination of interferon alfa-2b and ribavirin in liver transplant recipients with histological recurrent hepatitis C. Liver Transplantation 2002 Nov;8(11):1000-1006. PMID: 12424712

13. Teshima T, Ordemann R, Reddy P, Gagin S, Liu C, Cooke KR & Ferrara JM (2002)

Acute graft-versus-host disease does not require alloantigen expression on host epitheLium. Nature Medicine 8:575-581. (Cover article). PMID: 12042807

14. Hildebrandt, G.C., Duffner, U.A., Olkiewicz, K.M., Willmarth, N.E., Corrion, L.A.,

Clouthier, S., Williams, D.L., Reddy, P.R., Moore, B.B., Liu, C., and K.R. Cooke. (2003). A Critical Role for CCR2 in the development of idiopathic pneumonia syndrome after allogeneic bone marrow transplantation. Blood, 2004 103:2417-2426. PMID: 14615370

15. Duffner, U., Lu, B., Teshima, T., Williams, D.L., Hildebrandt, G., Reddy, P.,

Ordemann, R., Lowler, K., Liu, C., Cooke, K.R., and Ferrara J.L.M. (2003) Role of CXCR3-induced donor T-cell migration in acute GVHD. Experimental Hematolology. (10):897-902. PMID: 14550805

16. Nelson DR, Tu Z, Soldevila-Pico C, Abdelmalek M, Zhu H, Xu YL, Liu, C, Davis

GL (2003) Long-term interleukin 10 therapy in chronic hepatitis C patients has a proviral and anti-inflammatory effect. Hepatology, 38(4):859-68. PMID: 14512873

17. Clouthier S, Cooke KR, Teshima T, Lowler KP, Liu C, Connolly K, Ferrara JL

(2003) Repifermin (Keratinocyte Growth Factor-2), delays onset of graft-versus-host disease while preserving a graft-versus-leukemia effect. Biology of Bone marrow, Blood and Transplantation. (9):592-603. PMID: 14506661

18. Reddy P, Teshima T, Hildebrandt G, Williams DL, Liu C, Cooke KR, Ferrara JL.

(2003) Pretreatment of donors with interleukin-18 attenuates acute graft-versus-host disease via STAT6 and preserves graft-versus-leukemia effects. Blood 101(7):2877-85. PMID: 12433681

19. Teshima T, Reddy P, Liu C, Williams D, Cooke KR, Ferrara JL. (2003) Impaired

thymic negative selection causes autoimmune graft-versus-host disease. Blood 102(2):429-35. PMID: 12663438

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20. Ichiba T, Teshima T, Kuick R, Misek DE, Liu C, Takada Y, Maeda Y, Reddy P, Williams DL, Hanash S, Ferrara JL. (2003) Early changes in gene expression profiles of hepatic GVHD uncovered by oligonucleotid microarrays. Blood 102(2):763-71. PMID: 12663442

21. Petrovic, A; Alpdogan, O; Willis, LM; Eng, JM; Greenberg, AS; Kappel, BJ; Liu,

Cimportant homing integrin on alloreactive T cells in the development of intestinal Graft-Versus-Host Disease. Blood.103: 1542-1547. PMID: 14563643

22. Zhu, HZ; Liu, C. (2003) Interleukin 1 inhibits hepatitis C viral RNA replication by

activation of extracellular regulated kinase pathway. Journal of Virology. 77:5493-5498. PMID: PMC153991

23. Zhu, H.Z; Zhao, HS; Collins, CD; Eckenrode, SE; Run, Q; McIndoe, RA; Crawford,

JM; Nelson, DR; She, JX; Liu, C. Gene expression associated with IFN alpha antiviral activity in an HCV replicon cell line. (2003) Hepatology, 37:1180-1188. EDITORIAL: on page 975. PMID: 12717400

24. Hassanein A, Glanz S, Kessler H, Eskin T, Liu C (2003) Beta catenin is aberrantly

expressed in tumors expression shadow cells: pilomatricoma, craniopharyngioma, and calcifying odontogenic tumor. American J Journal of Clinical Pathology. 120(5):732-6. PMID: 14608900

25. Liu, C; Zhu, HZ; Xu, YL; Nelson, DR. (2003) CD8+ T cell interaction with HCV

replicon cells: evidence for both cytokine- and cell-mediated antiviral activity. Hepatology, 37:1335-1342. PMID: 12774012

26. Firpi RJ, Abdelmalek MF, Soldevila-Pico C, Cabrera R, Shuster JJ, Theriaque D,

Reed AI, Hemming AW, Liu C, Crawford JM, and Nelson DR.(2004) One-year Protocol Liver Biopsy Can Stratify Fibrosis Progression In Liver Transplant Recipients With Recurrent Hepatitis C Infection. Liver Transplantation. 40:1062-71. PMID: 15376304

27. Friedman JS, Alpdogan O, van den Brink MR, Liu C, Hurwitz D, Boyd A, Kupper

TS, Burakoff SJ. (2004) Increasing T-cell age reduces effector activity but preserves proliferative capacity in a murine allogeneic major histocompatibility complex-mismatched bone marrow transplant model. Biology of Blood Marrow Transplantation.10:448-60. PMID: 15205666

28. Hildebrandt, GC; Olkiewicz, KM; Chang, Y; Liu, C; Cooke, KR (2004) Donor-

dreived TNF regulates pulmonary chemokine expression and the development of idiopathic pneumonia syndrome after allogenic bone marraow transplantation. Blood, 104:586-93. PMID: 15069018

29. Persad, R; Liu, C; Wu, TT; Houlihan, PS; Hamilton, SR; Diehl, AM, Rashid, A

(2004) Overexpression of caspase 3 in hepatocellular carcinoma. Modern Pathology, 17(8) 1026. PMID: 15098015

30. Abdelmalek MF, Firpi RJ, Soldevila-Pico C, Reed AI, Hemming AW, Liu C,

Crawford JM, Davis GL, Nelson DR (2004) Sustained viral response to interferon and ribavirin in liver transplant recipients with recurrent hepatitis C. Liver Transplantation. 10(2):199-207. PMID: 14762857

31. Hildebrandt GC, Corrion, LA, Olkiewicz, KM, Lowler, K, Moore, BB, Kuziel, WA,

Liu, C and Cooke, KR. (2004) Blockade of CXCR3 receptor:ligand interactions

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reduces leukocyte recruitment to the lung and the severity of experimental idiopathic pneumonia syndrome Journal of Immunology, 173:2050-9. PMID: 15265940

32. Duffner, UA; Maeda, Y; Cooke, KR; Reddy, P; Ordemann, R; Liu, C; Ferrara, JL.

(2004) Host dendritic cells alone are sufficient to initiate acute graft-versus-host-disease. Journal of Immunology. 172:7393-7398 PMID: 15178116

33. Min CK, Maeda Y, Lowler K, Liu, C, Clouthier S, Lofthus D, Weisiger E, Ferrara

JL, Reddy P. (2004) Paradoxical effects of interleukin-18 on the severity of acute graft-versus-host disease mediated by CD4+ and CD8+ T cell subsets after experimental allogeneic bone marrow transplantation. Blood, 104:3393-3399. PMID: 15280194

34. Camp ER, Hochwald SN, Liu C. (2004) FAP with concurrent duodenal

adenomatous polyposis and carcinoid tumor. Journal of Surgical Oncology. 87(4):187-90. PMID: 15334634

35. Cabrera R, Tu Z, Xu Y, Firpi RJ, Rosen HR, Liu C, Nelson DR. (2004) An

immunomodulatory role for CD4(+)CD25(+) regulatory T lymphocytes in hepatitis C virus infection. Hepatology, 40: 1062-71. PMID: 15486925

36. Reddy P; Maeda, Y; Hotary, K; Liu C; Reznikove, LL; Dinarello, CA, Ferrara, JM

(2004) Histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces acute graft-versus-host disease and preserves graft-versus leukemia effect. Proceeding of National Academy of Science. U.S.A, 101:3921-3926. PMCID: PMC374345

37. Li, M; Liu, C. (2004) Cytokeratin 20 confirms Merkel cell metastasis to stomach.

Applied Immunohistochemistry and Molecular Morphology. 12:346-349. PMID: 15536335

38. Gerbitz A, Nickoloff BJ, Olkiewicz K, Willmarth NE, Hildebrandt G, Liu C, Kobzik

L, Eissner G, Holler E, Ferrara JL, Cooke KR. (2004) A role for tumor necrosis factor-alpha-mediated endothelial apoptosis in the development of experimental idiopathic pneumonia syndrome. Transplantation, 78:494-502. PMID: 15446306

39. Shang XZ, Zhu HZ, Tu ZK, Nelson DR, Liu C (2004) Stabilized beta catenin

promotes hepatocyte proliferation and inhibits TNF-induced apoptosis. Laboratory Investigation. 84:332-341. PMID: 14767485

40. Zhu H, Shang X, Terada N, Liu C (2004) STAT3 induces anti-hepatitis C viral

activity. Biochem Biophys Res Commun. 343:518-528. PMID: 15474458

41. Hildebrandt GC, Olkiewicz KM, Choi S, Corrion LA, Clouthier SG, Liu C, Serody JS, Cooke KR. (2005) Donor T cell-production of RANTES significantly contributes to the development of Idiopathic Pneumonia Syndrome after allogeneic stem cell transplantation. Blood, 105:2249-2257. PMID: 15546955

42. Maeda Y, Levy RB, Reddy P, Liu C, Clouthier SG, Teshima T, Ferrara JL. (2005)

Both perforin and Fas ligand are required for the regulation of alloreactive CD8+ T cells during acute graft-versus-host disease. Blood. 105:2023-2027. PMID: 15466930

43. Hashimoto D, Asakura, S, Miyake S, Yamamura T, Kaer L, Liu C, Tanimoto M,

Teshima T. (2005) Stimulation of host natural killer T cells by synthetic glycolipid regulates acute graft-versus host disease by inducing Th2 polarization of donor T cells. Journal of Immunology, 174:551-556 PMID: 15611282

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44. Cresawn KO, Fraites, TJ, Wasserfall C, Atkinson M, Lewis M, Porvasnik S, Liu C, Mah C, Byrne BJ. (2005) Correction of glycogen storage disease type II from intrahepatic delivery of rAAV and rAAV8 vectors is dependent on an inhibitory antibody response. Gene Therapy, 2005 Jan;16(1):68-80 PMID: 15703490

45. Gerbitz A, Ewing P, Olkiewicz K, Willmarth NE, Williams D, Hildebrandt G, Wilke

A, Liu C, Eissner G, AndreesenR, Holler E, Guo R, Ward PA, Cooke KR. (2005) A role for CD54 (intercellular adhesion molecule-1) in leukocyte recruitment to the lung during the development of experimental idiopathic pneumonia syndrome. Transplantation,79:536-542 PMID: 15753842

46. Maeda Y, Reddy P, Lowler KP, Liu C, Bishop DK, FerraraJL. (2005) Critical role

of host {gamma}{delta} T cells in experimental acute graft-versus-host disease. Blood. 2005 Jul 15;106(2):749-55 PMCID: PMC1895173

47. Rufforny I, Wilkinson EJ, Zhu H, Buteral M, Liu C, Massoll NA. (2005) Human

papillomavirus infection and p16(INK4a) protein expression in vulvar intraepithelial neoplasia and invasive squamous cell carcinoma Journal of Low Genital Tract Disease. 9(2):108-13 PMID: 15870532

48. Zhu HZ, Nelson DR, Crawford JM, Liu C. (2005) Defective JAK-STAT pathway is

associated with HCV interferon resistance. Journal Interferon & Cytokine Research. 25:528-539 PMID: 16181053

49. Marsh RW, Walker MH, Liu C. (2005) Breast implants as a possible etiology of

epithelioid hemangioendothelioma and successful therapy with interferon-alpha2. Breast Journal. 4: 257-261 PMID: 15982392

50. Terwey TH, Kim TD, Kochman AA, Hubbard VM, Lu S, Zakrzewski JL, Ramirez-

Montagut T, Eng JM, Muriglan SJ, Heller G, Murphy GF, Liu C, Budak-Alpdogan T, Alpdogan O, van den Brink MRM. (2005) CC chemokine receptor 2 is required for CD8-induced graft-versus-host disease. Blood. 2005 Nov 1;106(9):3322-30 PMID: PMC1895329

51. Hubbard VM, Eng JM, Ramirez-Montagut T, Tjoe KH, Kochman AA, Terwey TH,

Willis LM, Schiro R. Heller G, Murphy GF, Liu C, Alpdogan O, Van den Brink MR. (2005) Absence of inducible costimulator on alloreactive T cell reduces graft-versus-host disease and induces Th2 deviation. Blood, 2005 Nov 1;106(9):3285-92 PMCID: PMC1895338

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JW, Jakubowski AA, Zaidi B, Gallardo H, Liu C, Rasalan T, Wolchok JD, Croughs T, Morre M, Devlin SM, van den Brink MR. (2012) Recombinant human interleukin-7 (CYT107) promotes T-cell recovery after allogeneic stem cell transplantation. Blood. 2012 Dec 6;120(24):4882-91. PMCID: PMC3520625

141. Tawara I, Sun Y, Liu C, Toubai T, Nieves E, Evers R, Alrubaie M, Mathewson N,

Tamaki H, Reddy P (2012). Donor- but not host-derived interleukin-10 contributes to the regulation of experimental graft-versus-host disease. Journal of Leukocyte Biology. 2012 Apr;91(4):667-75. Epub 2012 Jan 18. PMCID: PMC3317273

142. Jenq RR, Ubeda C, Taur Y, Menezes CC, Khanin R, Dudakov JA, Liu C, West ML,

Singer NV, Equinda MJ, Gobourne A, Lipuma L, Young LF, Smith OM, Ghosh A, Hanash AM, Goldberg JD, Aoyama K, Blazar BR, Pamer EG, van den Brink MR (2012). Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation. Journal of Experimental Medicine. 2012 May 7;209(5):903-11. Epub 2012 Apr 30. PMCID: PMC3348096

143. Ogunwobi OO, Wang T, Zhang L, Liu C. (2012) Cyclooxygenase-2 and Akt

mediate multiple growth-factor-induced epithelial-mesenchymal transition in human hepatocellular carcinoma. Journal of Gastroenterology and Hepatology. 2012 Mar;27(3):566-78. PMCID: PMC3288221

144. Liu H, Trinh TL, Dong H, Keith R, Nelson D, Liu C (2012). Iron regulator hepcidin

exhibits antiviral activity against Hepatitis C Virus. PLoS ONE 7(10): e46631. doi:10.1371. PMCID: PMC3478283

145. Wang ZL, Liu HY, Yang SH, Liu C and Cao YW (2012) Nanoparticle-based

artificial RNA silencing machinery for antiviral therapy. Proceeding of National Academy of Science. U.S.A, 109(31):12387-92. (shared senior authorship). PMCID: PMC3412013

146. Cabrera R, Fitian AI, Ararat M, Xu Y, Brusko T, Wasserfall C, Atkinson MA, Liu

C, Nelson DR.(2012) Serum levels of soluble CD25 as a marker for hepatocellular carcinoma. Oncology Letter. 2012 Oct;4(4):840-846. Epub 2012 Jul 26. PMCID: PMC3506698

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147. Xiong X, Liu H, Zhao Z, Altman MB, Lopez-Colon D, Yang CJ, Chang LJ, Liu C,

Tan W.DNA aptamer-mediated cell targeting. (2013) Angew Chemistry Int Ed Engl. 2013 Jan 28;52(5):1472-6. PMCID: PMC3793636

148. Jin B, Ernst J, Tiedemann RL, Xu H, Sureshchandra S, Kellis M, Dalton S, Liu C,

Choi JH, Robertson KD. (2012) Linking DNA methyltransferases to epigenetic marks and nucleosome structure genome-wide in human tumor cells. Cell Report. 2012 Nov 29;2(5):1411-24. PMCID: PMC3625945

149. Alkhasawneh A, Dong HJ, Liu C, Allegra C, Allan RW (2012) The Role of KRAS

Mutational Analysis to Determine the Site of Origin of Metastatic Carcinoma to the Lung: A Case Report. Case Report Pathology. 2012:425967. PMCID: PMC3483662

150. Cabrera R, Ararat M, Xu Y, Brusko T, Wasserfall C, Atkinson MA, Chang LJ, Liu

C, Nelson DR. (2013) Immune modulation of effector CD4+ and regulatory T cell function by sorafenib in patients with hepatocellular carcinoma. Cancer Immunology and Immunotherapy. 2013 Apr;62(4):737-46 2012 Dec 7. [Epub ahead of print]. PMCID: PMC3863727

151. Martelli MG, Liu C. (2013) Malignant rhabdoid tumour of the liver in a seven-

month-old female infant: a case report and literature review. Afr Journal of Paediatric Surgery. 2013 Jan-Apr;10(1):50-4. PMID: 23519861

152. Firpi RJ, Dong H, Clark VC, Soldevila-Pico C, Morelli G, Cabrera R, Norkina O,

Shuster JJ, Nelson DR, Liu C. (2013) CC genotype donors for the interleukin-28B single nucleotide polymorphism are associated with better outcomes in hepatitis C after liver transplant. Liver International, 33(1):72-8. PMID: 23519861

153. Yu Y, Wang D, Kaosaard K, Liu C, Fu J, Haarberg K, Anasetti C, Beg AA, Yu XZ

(2013) c-Rel is an essential transcription factor for the development of acute graft-versus-host disease in mice. European Journal of Immunology. 43(9):2327-37. PMCID: PMC3940138

154. Li J, Heinrichs J, Leconte J, Haarberg K, Semple K, Liu C, Gigoux M, Kornete M,

Piccirillo CA, Suh WK, Yu XZ. (2013) Phosphatidylinositol 3-kinase-independent signaling pathways contribute to ICOS-mediated T cell costimulation in acute graft-versus-host disease in mice. Journal of Immunology. 191(1):200-7. PMCID: PMC4318500

155. Ghosh A, Holland AM, Dogan Y, Yim NL, Rao UK, Young LF, West ML, Singer

NV, Lee H, Na IK, Tsai JJ, Jenq RR, Penack O, Hanash AM, Lezcano C, Murphy GF, Liu C, Sadelain M, Sauer MG, Sant'angelo D, van den Brink MR.(2013) PLZF confers effector functions to donor T cells that preserve graft-versus-tumor effects while attenuating GVHD. Cancer Research. 73(15):4687-96. PMCID: PMC3732814

156. Kirst ME, Li EC, Wang CX, Dong HJ, Liu C, Fried MW, Nelson DR, Wang GP.

(2013) Deep sequencing analysis of HCV NS3 resistance-associated variants and mutation linkage in liver transplant recipients. PLoS One. 2013 Jul 29;8(7):e69698 PMCID: PMC3726766

157. Toubai T, Sun Y, Luker G, Liu J, Luker KE, Tawara I, Evers R, Liu C, Mathewson

N, Malter C, Nieves E, Choi S, Murphy KM, Reddy P. (2013) Host-derived CD8+ dendritic cells are required for induction of optimal graft-versus-tumor responses after experimental allogeneic bone marrow transplantation. Blood. 2013 May 16;121(20):4231-41. Epub 2013 Mar 21. PMCID: PMC3656455

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158. Carcamo WC, Ceribelli A, Calise SJ, Krueger C, Liu C, Daves M, Villalta D, Bizzaro N, Satoh M, Chan EK.(2013) Differential reactivity to IMPDH2 by anti-rods/rings autoantibodies and unresponsiveness to pegylated interferon-alpha/ribavirin therapy in US and Italian HCV patients. Journal of Clinical Immunology. 2013 Feb;33(2):420-6. PMID: 23100146

159. Ghosh A, Dogan Y, Moroz M, Holland AM, Yim NL, Rao UK, Young LF,

Tannenbaum D, Masih D, Velardi E, Tsai JJ, Jenq RR, Penack O, Hanash AM, Smith OM, Piersanti K, Lezcano C, Murphy GF, Liu C, Palomba ML, Sauer MG, Sadelain M, Ponomarev V, van den Brink MR. (2013) Adoptively transferred TRAIL+ T cells suppress GVHD and augment antitumor activity. Journal of Clinical Investigation. 123(6):2654-62. PMCID: PMC3668849

160. Chen BJ, Jiao Y, Zhang P, Sun AY, Pitt GS, Deoliveira D, Drago N, Ye T, Liu C,

Chao NJ. Long-term in vivo imaging of multiple organs at the single cell level. PLoS One. 2013;8(1):e52087. PMCID: PMC3534688

161. Zhao X, Tian C, Puszyk WM, Ogunwobi OO, Cao M, Wang T, Cabrera R, Nelson

DR, Liu C. (2013) OPA1 downregulation is involved in sorafenib-induced apoptosis in hepatocellular carcinoma. Laboratory Investigation. 2013 Jan;93(1):8-19. Cover Article. PMCID: PMC3860369

162. Haarberg KM, Li J, Heinrichs J, Wang D, Liu C, Bronk CC, Kaosaard K, Owyang

AM, Holland S, Masuda E, Tso K, Blazar BR, Anasetti C, Beg AA, Yu XZ. (2013). Pharmacologic inhibition of PKCα and PKCθ prevents GVHD while preserving GVL activity in mice. Blood. 2013 Aug 1. [Epub ahead of print]. PMCID: PMC3790515

163. Zhu GZ, Jing Z, Song E, Donovan M, Zhang K, Liu C, Tan WH (2013) Self-

assembled, Aptamer-tethered DNA Nanotrains for Targeted Transport of Molecular Drugs in Cancer Theranostics. Proceeding of National Academy of Science. U.S.A,. 110(20):7998-8003. PMCID: PMC3657780

164. Puszyk WM, Trinh TL, Chapple SJ, Liu C. (2013) Linking metabolism and

epigenetic regulation in development of hepatocellular carcinoma. Laboratory Investigation. Sep;93(9):983-90. Epub 2013 Aug 5. PMCID: PMC4028619

165. Ogunwobi O, Puszyk W, Dong HJ, Liu C (2013) Epigenetic upregulation of HGF

and c-Met drives metastasis in hepatocellular carcinoma. PloS One 8(5):e63765. PMCID: PMC3665785

166. Tiedemann RL, Putiri EL, Lee JH, Hlady RA, Kashiwagi K, Ordog T, Zhang Z, Liu

C, Choi JH, Robertson KD. (2014) Acute depletion redefines the division of labor among DNA methyltransferases in methylating the human genome. Cell Report. 2014 Nov 20;9 (4):1554-66. PMCID: PMC4254561

167. Sheng W, Olorunseun O, Chen T, Zhang J, George TJ, Liu C , Fan H (2014)

Capture, Release and Culture of Circulating Tumor Cells in Pancreatic Cancer Patients using an Enhanced Mixing Chip. Lab Chip. 2014 Jan 7;14(1):89-98. Epub 2013 Nov 13. PMCID: PMC3918168

168. Putiri EL, Tiedemann RL, Liu C, Choi JH, Robertson KD. (2014) Impact of human

MLL/COMPASS and polycomb complexes on the DNA methylome. Oncotarget. 2014 Aug 15;5(15):6338-52 PMCID: PMC4171634

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169. Fitian, AI, Nelson DR, Ogunwobi O, McIntyre LM, Xu Y, Liu C, Cabrera R (2014) Identification of Metabolic Biomarkers of Hepatocellular Carcinoma in Hepatitis C Cirrhosis. Liver International 2014 Oct;34(9):1428-44 PMID: 25443348

170. George T, Trevino J, Liu C (2014) Src Inhibition Is Still a Relevant Target in

Pancreatic Cancer. The Oncologist. 2014;19:211. PMCID: PMC3926798

171. Jacob SV, Reith JD, Kojima AY, Williams WD, Liu C, Vila Duckworth L. (2014) An Unusual Case of Systemic Inflammatory Myofibroblastic Tumor with Successful Treatment with ALK-Inhibitor. Case Rep Pathology. 2014:470340. PMCID: PMC4087275

172. Hubbard-Lucey VM, Shono Y, Maurer K, West ML, Singer NV, Ziegler CG,

Lezcano C, Motta AC, Schmid K, Levi SM, Murphy GF, Liu C, Winkler JD, Amaravadi RK, Rogler G, Dickinson AM, Holler E, van den Brink MR, (2014) Cadwell K. Autophagy gene Atg16L1 prevents lethal T cell alloreactivity mediated by dendritic cells. Immunity. Oct 16;41(4):579-91. doi: 10.1016/j.immuni.2014.09.011. Epub 2014 Oct 9.PMID: 25308334

173. Liu N, Long Y, Liu B, Yang D, Li C, Chen T, Wang X, Liu C, Zhu H. (2015) ISG12a mediates cell response to Newcastle disease viral infection. Virology. 2014 Aug;462-463:283-94. PMCID: PMC4041170

174. Hubbard-Lucey VM, Shono Y, Maurer K, West ML, Singer NV, Ziegler C, Lezcano

C, Motta A, Schmid K, Levi SM, Murphy GF, Liu C, Winkler JD, Amaravadi RK, Rogler G, Dickinson AM, Holler E, van den Brink MRM, and Cadwell K (2014) Autophagy gene Atg16l1 prevents lethal T cell alloreactivity mediated by dendritic cells. Immunity, 2014 Oct 16;41(4):579-91 PMCID: PMC4237219

175. Shono Y, Tuckett AZ, Ouk S, Liou HC, Altan-Bonnet G, Tsai JJ, Oyler JE, Smith

OM, West ML, Singer NV, Doubrovina E, Pankov D, Undhad CV, Murphy GF, Lezcano C, Liu C, O'Reilly RJ, van den Brink MR, Zakrzewski JL. (2014) A small-molecule c-Rel inhibitor reduces alloactivation of T cells without compromising antitumor activity. Cancer Discovery. 4(5):578-91 PMCID: PMC4011979

176. Duckworth LV, Gonzalez RS, Martelli M, Liu C, Coffin CM, Reith JD (2014)

Plexiform fibromyxoma: report of two pediatric cases and review of the literature. Pediatr Dev Pathol. 2014 Jan-Feb;17(1):21-7. PMID: 24160555

177. George TJ, Ogunwobi OO, Sheng W, Fan H, Liu C (2014) “Tissue is the Issue”:

Circulating Tumor Cells in Pancreatic Cancer”. Journal of Gastrointest Cancer. 2014 Dec;45 Suppl 1:222-5 PMID: 25012516

178. Toubai T, Hou G, Mathewson N, Liu C, Wang Y, Oravecz-Wilson K, Cummings E,

Rossi C, Evers R, Sun Y, Wu J, Choi SW, Fang D, Zheng P, Liu Y, Reddy P. (2014) Siglec-G-CD24 axis controls the severity of graft-versus-host disease in mice. Blood. 123(22):3512-23. PMCID: PMC4041170

179. Hlady RA, Tiedemann RL, Puszyk W, Zendejas I, Roberts LR, Choi JH, Liu C,

Robertson KD (2014). Epigenetic signatures of alcohol abuse and hepatitis infection during human hepatocarcinogenesis. Oncotarget. 2014 Oct 15;5(19):9425-4 (Senior Author) PMCID: PMC4253444

180. Zhao XX, Puszyk W, Robertson K, Ostrov DA, George T, Liu C. (2015) Small

molecule inhibitor YM155-mediated activation of death receptor 5 is crucial for chemotherapy-induced apoptosis in pancreatic carcinoma. Molecular Cancer Therapeutics. 2015 Jan;14(1):80-9. Epub 2014 Oct 24. PMCID: PMC4387779

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181. Delitto D, Pham K, Claudiu V, Sarosi GA, Ryan T, Behrns KE, Liu C,

Hughes,Steven J Hughes S, Wallet SM, Trevino J (2015) Patient-Derived Xenograft Models for Pancreatic Adenocarcinoma Demonstrate Retention of Tumor Morphology through Incorporation of Murine Stromal Elements. American Journal of Pathology. 185(5):1297-303 PMID: 25770474 PMCID: PMC4419203

182. Fu J, Wang D, Yu Y, Heinrichs J, Wu Y, Schutt S, Kaosaard K, Liu C, Haarberg K,

Bastian D, McDonald DG, Anasetti C, Yu XZ. (2015) T-bet is critical for the development of acute graft-versus-host disease through controlling T cell differentiation and function. Journal of Immunology. 2015 Jan 1;194(1):388-97. PMCID: PMC4314960

183. Pi L, Robinson PM, Jorgensen M, Oh SH, Brown AR, Weinreb PH, Trinh TL,

Yianni P, Liu C, Leask A, Violette SM, Scott EW, Schultz GS, Petersen BE. (2015) Connective tissue growth factor and integrin αvβ6: a new pair of regulators critical for ductular reaction and biliary fibrosis in mice. Hepatology. 2015 Feb;61(2):678-91 PMCID: PMC4303530

184. Zuo C, Xia M, Wu Q, Zhu H, Liu J, Liu C. (2015) Role of antiviral therapy in

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185. Zuo C, Qiu X, Liu N, Yang D, Xia M, Liu J, Wang X, Zhu H, Xie H, Xie P, Wu Q,

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186. Auletta JJ, Eid SK, Wuttisarnwattana P, Silva I, Metheny L, Keller MD, Guardia-

Wolff R, Liu C, Wang F, Bowen T, Lee Z, Solchaga LA, Ganguly S, Tyler M, Wilson DL, Cooke KR. (2015) Human mesenchymal stromal cells attenuate graft-versus-host disease and maintain graft-versus-leukemia activity following experimental allogeneic bone marrow transplantation. Stem Cells. 2015 Feb;33(2):601-14. PMCID: PMC4304927

187. Delitto D, Pham K, Vlada AC, Sarosi GA, Thomas RM, Behrns KE, Liu C, Hughes

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188. Delitto D, Zhang D, Han S, Black BS, Knowlton AE, Vlada AC, Sarosi GA, Behrns

KE, Thomas RM, Lu X, Liu C, George TJ, Hughes SJ, Wallet SM, Trevino JG. (2015) Nicotine Reduces Survival via Augmentation of Paracrine HGF-MET Signaling in the Pancreatic Cancer Microenvironment. Clin Cancer Res. Dec 14. [Epub ahead of print] PMID: 26667487 Select item 26498838

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191. Zhang J, Ramadan AM, Griesenauer B, Li W, Turner MJ, Liu C, Kapur R, Hanenberg H, Blazar BR, Tawara I, Paczesny S (2015) ST2 blockade reduces sST2-producing T cells while maintaining protective mST2-expressing T cells during graft-versus-host disease.Sci Transl Med. Oct 7;7(308):308ra160. doi: 10.1126/scitranslmed.aab0166. PMID: 26446957

192. Schutt SD, Fu J, Nguyen H, Bastian D, Heinrichs J, Wu Y, Liu C, McDonald DG,

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193. Sun Y, Oravecz-Wilson K, Mathewson N, Wang Y, McEachin R, Liu C, Toubai T,

Wu J, Rossi C, Braun T, Saunders T, Reddy P. (2015) Mature T cell responses are controlled by microRNA-142. J Clin Invest. Jul 1;125(7):2825-40. doi: 10.1172/JCI78753. Epub Jun 22. PMID: 26098216

194. Li J, Heinrichs J, Haarberg K, Semple K, Veerapathran A, Liu C, Anasetti C, Yu XZ

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195. Sun Y, Wang Y, Toubai T, Oravecz-Wilson K, Liu C, Mathewson N, Wu J, Rossi C,

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196. Fu J, Wang D, Yu Y, Heinrichs J, Wu Y, Schutt S, Kaosaard K, Liu C, Haarberg K, Bastian D, McDonald DG, Anasetti C, Yu XZ. (2015) T-bet is critical for the development of acute graft-versus-host disease through controlling T cell differentiation and function. J Immunol. Jan 1;194(1):388-97. doi: 10.4049/jimmunol.1401618. Epub 2014 Nov 17.PMID: 25404360

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199. Trinh TL, Zhu G, Xiao X, Puszyk W, Sefah K, Wu Q, Tan W, Liu C. (2015) A

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202. Lindemans CA, Calafiore M, Mertelsmann AM, O'Connor MH, Dudakov JA, Jenq

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Books, Monographs and Chapters

a. Wu TT, Condreay LD, Liu C, Mason WS and Jibert JR (1991) Hepadnavirus DNA synthesis. In: 1990 international symposium on viral hepatitis and liver disease ed. Hollinger, B; Margolis H; William and Wilkins. 114-121.

b. Mason WS, Summers J, Liu C, Condreay LD, Wu TT (1991) Chronic

hepadnavirus infection. In: international symposium on hepatitis delta virus, ed. Gerin, J; Purcell; Rizetto, M Wiley-Liss, Inc. 235-242.

c. Liu C; Crawford JM. (2003) Liver anatomy. In: Madara ed.

“Encyclopedia of Gastroenterology.” pp 510-515.

d. Liu C; Crawford JM. (2003) Liver biopsy. In: Madara ed. “Encyclopedia of Gastroenterology.” pp. 516-522.

e. Liu C; Crawford JM. (2004) Chapter 17, Pathology of gastrointestinal

tract. In “Robbins Pathologic Basis of Disease”. 7 th edn. pp. 410-474.

f. Liu C; Crawford JM. (2004) Graft-versus-Host Disease of the Liver.

In: Ferrara ed. “Graft-vs-Host Disease.” 3 rd edn. Marcel Dekker, New Yrok. pp: 257-278.

g. Liu C; Crawford JM (2005) Chapter 17 and 18, in “Robbins and

Cotran Pathologic Basis of Disease.” Pocket book. pp. 516-522.

h. Liu C (2006) Hepatitis C Virology and Experimental Models. “Clinics in Liver Disease”. 10:773-791.

i. Liu C (2009) Primary Hepatocyte Culture in HCV Research.

"Hepatitis C Protocols". Methods Mol Biol. 2009;510:373-82.

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j. Liu C, Crawford JM (2009) Chapter 18, Liver Pathology, in Robbins and Cotran Pathologic Basis of Disease, 8 th ed.

k. Liu C, Crawford JM. (2009) Pathological staging of biliary tract

cancers. In Biliary Tract and Gallbladder Cancers. Pp. 77-84 Ed. Thomas and Fuller, Demos Medical, New York.

l. Kim Y, Liu C, Tan WH, (2009) Aptamers generated by cell-based

SELEX for biomarker discovery. Biomark Med. 2009 Apr;3(2):193-202.

m. Ogunwobi O, Liu C. (2011) Therapeutic markers for liver cancer

metastasis. Critical Reviews in Oncology/Hematology. 2012 Sep;83(3):319-28, 2011 Dec 16. [Epub ahead of print].

n. Tan W, Wang H, Chen Y, Zhang X, Zhu H, Yang C, Yang R, Liu C.

(2011) Molecular aptamers for drug delivery. Trends Biotechnology. 2011 Dec;29(12):634-40.

o. Liu C (2012) Guardian and selective killer: the versatile functions of

TLR3 in hepatocellular carcinoma. J National Cancer Institute. 2012 Dec 5;104(23):1780-2.

212. Patents Held 1. Human Liver Cancer Cell Line, US patent 8017391, issued September 2011 2. Compounds for alpha-1 antitrypsin deficiency treatment, US patent 6403646, issued

May 2013 3. Anti-HCV small molecules, US patent application, filed in May 2009 4. New polypeptide for alpha-1 antitrypsin deficiency, US patent application,

US12/522,958 5. Epigenetic markers for liver cancer, US patent application, filed in January, 2011 6. Nanozyme as a new therapeutic agent for infection and cancer, US patent

application, filed in March 2011

213. Other Articles (Reviews, Editorials, etc.) In Journals; Chapters; Books; other

Professional Communications See Section B

214. Abstracts 1. Jose Varillas, Weian Sheng, Kangfu Chen, Thomas George, Liu C, Hugh Fan. Capture of Circulating Tumor Cells (CTCs) in Microfluidic Devices for Patient Treatment Monitoring. BMES 2015 Annual Meeting, scheduled for October 7-10, 2015 2. Thu Le Trinh, Guizhi Zhu, Xilin Xiao, Xiaokui Zhang, Kwame Sefah, Weihong Tan, and Liu C. AS1411-Doxorubicin adduct for targeted liver cancer therapy. 2013 AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics Conference, October 19-23, Boston MA. 3. Olorunseun O. Ogunwobi, Thu L. Trinh, and Liu C. Human glypican-3 promotes hepatocellular carcinoma progression via induction of epithelial-mesenchymal transition. AACR 103rd Annual Meeting 2012-- Mar 31-Apr 4, 2012; Chicago, IL 4. Thu Le Trinh, K. Safah, W. Tan, Liu C. AS1411 as a Potential Anti-Cancer Reagent for Treatment of Hepatocellular Carcinoma. 24th EORTC-NCI-AACR

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symposium on ‘Molecular targets and cancer therapeutics’– 6-9 November 2012, Dublin, Ireland. 5. Thu Le Trinh and Liu C. Glypican-3 as a potential therapeutic target for hepatocellular carcinoma immunotherapy. Experimental biology 2012– April 21-25, 2012; San Diego, CA 6. Jeung J, Patel R, Wakefield D, Liu C Characterization of HER2 Expression in Primary Gastroesophageal adenocarcinoma. USCAP 100th Annual Meeting, Feb. 2011, Modern Pathology, 24:153A. 7. Liu J, Zhu HZ, Liu HY, Nelson, DR, Liu C (2010) TRAIL agonist resistance is associated with death receptor mutations. Digestive Disease Week, May, 2010. (Oral Presentation) 8. Ogunwobi OO, Liu C. Hepatocyte growth factor upregulation and signaling is associated with carcinogenesis and mesenchymal characteristics in hepatocellular carcinoma. American Association for Cancer Research Annual Meeting, Orlando, Florida, USA, April 2011. 9. Ogunwobi OO, Zhang L, Liu C. Multiple growth factors induce epithelial-mesenchymal transition in novel liver cancer cell lines. American Association for Cancer Research Special Conference on EMT and Cancer Progression and Treatment, Arlington, Virginia, USA, February 2010. 10. Gilliland K, Dong, HJ, Hochwald, S, Liu C The role of k-ras mutations in pancreatic neuroendocrine tumors. USCAP Annual Meeting, March, 2010. Modern Pathology, 23:355A. 11. Liu C, Cardona D, Dong J K-ras mutations in hepatocellular carcinoma. USCAP Annual Meeting, March, 2010, Modern Pathology, 23:363A. 12. Zhao XX, Zhu HZ, Zhang XK, Liu J, Nelson DR, and Liu C Cycloheximide sensitizes TRAIL-agonist-induced apoptosis in liver cancer cells AACR Cell death mechanisms and cancer therapy Feb, San Diego, CA, 2010 13. Culture and immortalization of hepatitis C viral positive human hepatocytes. Poster, AASLD, 2003. Hepatology, 34: 462A

215. Reports

N/A PRESENTIONS:

A. Scientific (Basic Science): 2001 University of Michigan, Liver pathology in graft-versus-host disease.

2003 Institute for Medicinal Biotechnology, Chinese Academy of Medical Sciences.

Interferon signaling in hepatitis C viral infection. 2003 Institute for Infectious Diseases, Beijing, China. Functional genomics in

hepatitis C viral infection. 2004 Keynote speaker, Shandong University, China, Hepatitis C diagnosis and

therapy. 2005 Harvard Medical School, Innate and adaptive immunity in HCV infection.

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2005 Invited speaker, Alpha-1 Foundation International Scientific Conference, Small

molecules for AAT deficient therapy. 2007 Invited speaker, Chinese Academy of Medical Sciences, Innate immunity in

HCV. 2008 Invited speaker, China Medical University, Novel therapy for liver cancer. 2008 Falk Symposium, Mainz, Germany, Trail agonists for liver cancer therapy 2008 Invited speaker, Inner Mongolia Medical College. Liver disease updated

therapies. 2008 College of Veterinary Medicine, University of Florida. Innate Immunity 2008 Harvard Medical School and Brigham and Women's Hospital, TRAIL pathway

in hepatitis C viral infection and liver cancer. 2008 Invited speaker, Moffitt Cancer Center. Immunotherapy for HCV and liver

cancer. 2008 Keynote speaker, Florida State University, Innate immunity in hepatitis C

infection 2008 Duke University Medical Center, "Apoptosis in HCV and Liver cancer". 2009 Invitrogen Inc. " Liver cell line and mouse model in liver disease research. 2009 Keynote speaker and scientific session chair, 2nd World cancer congress 2009. Invited speaker, Beijing University, "Hepatitis C animal models". 2009 Invited speaker, Hunan University "Liver cancer therapy, current progress". 2009 Invited speaker, Chinese Academy of Sciences, "Aptamer in translational

medicine". 2010 Invited speaker, Penn State School of Medicine, "TRAIL-agonists in liver

cancer therapy".

2010 Invited speaker, Drexel University, Institute of Biotechnology. Apoptosis and liver cancer therapy.

2011 Invited speaker, Medical College of Georgia. "Developing novel therapeutic

strategies for liver cancer." 2012 Invited speaker, University of Kentucky. "Immunotherapy for Liver Cancer". 2012 Invited speaker, 5th International Symposium on Bioanalysis, Biomedical

Engineering and Nanotechnology. "Nanotechnology application in cancer therapy".

2013 Invited speaker, 14th SCBA International symposium “ Epigenetic and genetic factors in hepatitis C infection and treatment response”

2014 Invited speaker, Duke University Medical Center

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“Liver Cancer in the Era of Personalized Medicine”

2014 Invited Speaker, Rutgers University New Jersey Medical School “Immunotherapy for Liver Cancer” 2014 Invited Speaker, Dartmouth Medical School “Therapeutic Strategies for Liver Cancer Therapy”

B. Professional (Clinical): 2003 University of Florida, Cancer Center, Grand Round.

Pathogenesis of Liver Cancer. 2004 University of Florida, Division of Critical Care & Pulmonary Medicine.

Hepatic injury in alpha-1 antitrypsin deficiency. 2005 Grand rounds, University of Florida Cancer Center.

Liver Cancer Diagnosis and Therapy. 2007 Invited speaker, US-Canadian Academy of Pathology Annual Meeting

Hepatocellular Lesions: Diagnosis and differential diagnosis. 2009 Invited speaker, Hunan University "Liver cancer therapy, current progress". 2010 Invited speaker, Chinese pathology association annual conference, Chongqing,

China, Pathology of Liver Lesions

2011 Invited speaker, University of Louisville. "Hepatocellular carcinoma in the era of personalized medicine."

2014 Grand Rounds, Department of Pathology, Tulane University

“Immunotherapy for Liver Cancer”. 2014 Grand Rounds, University of Florida Cancer Center

“Mechanisms of Cancer Metastasis”.

2014 Grand Rounds, Case Western Reserve University “Liver Cancer, A Translational Approach”

2014 Grand Rounds, The Methodist Hospital, Houston, Texas “Personalized Medicine for Liver Cancer Therapy”. 2014 Invited Speaker, North America Neuroendocrine Tumor Society meeting,

Orlando “Pathology of GI and Liver neuroendocrine tumor”. 2014 Grand Rounds, Tulane University “Liver cancer immunotherapy”