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Understanding functional diversity of brain regions and brain networks. Luiz Pessoa Department of Psychology Maryland Neuroimaging Center University of Maryland, College Park. Joint work with. Michael Anderson: Franklin & Marshall Lucina Uddin : Stanford/University of Miami - PowerPoint PPT Presentation
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Understanding functional diversity of brain regions and brain networksLuiz PessoaDepartment of Psychology Maryland Neuroimaging CenterUniversity of Maryland, College Park1Joint work withMichael Anderson: Franklin & Marshall
Lucina Uddin: Stanford/University of Miami
Josh Kinnison: University of MarylandOne-to-one mapping
A1A2A3A4F1F2F3F4amygdalafearStructure-function mapping3Many-to-many mapping
A1A2A3A4F1F2F3F4Structure-function mappingamygdalafearvalueventral striatum4Structure-function mapping
EmotionCognitionMotivationPerceptionAction
?5Functional fingerprintUnderstanding brain regions via functional repertoires: multidimensional
RegionsPassingham et al. (2002)6Functional fingerprintUnderstanding brain regions via functional repertoires: imaging data
BrainMapNeuroSynthTask domains(ontology)7Functional fingerprintUnderstanding brain regions via functional repertoires: imaging data
8Functional diversity indexRegions will be more or less diverse
Use Shannon Entropy
Anderson, Kinnison, and Pessoa (2013), Neuroimage9Voxelwise diversity H
10
Functional diversity: networks
11
Functional diversity: networks
Network fingerprint12Brain networks
Fronto-parietal attention network(co-activation of BrainMap data)Toro et al. (2008)13Functional fingerprint
14Brain networks
Cingulo-parietal resting-state network(co-activation of BrainMap data)Toro et al. (2008)15Functional fingerprint
16Understanding insula function
Deen et al. (2010)Understanding insula function
Uddin et al. (submitted)Determine co-activation partners(using NeuroSynth)Understanding insula functionUddin et al. (submitted)Determine co-activation partners(using NeuroSynth)
Understanding insula functionUddin et al. (submitted)Determine co-activation partners(using NeuroSynth)
Understanding insula function
Common fingerprintAll insula sub-sectors are highly diverse(cf. tripartite cognitive-affective-interoceptive scheme)Understanding insula functionSpecific fingerprint components
Left dorsal anterior insulameanPhonologyWorking memoryReasoningSadnessHappinessFearUnderstanding insula function
Specific fingerprint components Dorsal Posterior VentralCognitiveAffectiveBrain networksFronto-parietal: attentionCingulo-opercular: resting-stateDorsal attention: endogenous attentionVentral attention: exogenous attentionFronto-parietal: rapid adaptive controlCingulo-opercular: stable set control
List goes on and onToro et al. (2008)24How to compare networks?
Task positiveTask negative25How to compare networksEvaluate whether two sets (i.e., networks) of fingerprints are drawn from the same parent distributionStatistical energy (Aslan and Zech, 2005)
26How to compare networksStatistical energy
XY27Comparing networksPermutation testing of XY
Task-positive vs. Task-negative(co-activation data)
Task-positive (co-activation; Toro et al. 2008) vs. Dorsal attention(resting-state; Yeo et al. 2011)28Are brain networks assortative?Assortativity: like connects with like
29How to compare networksStatistical energyFunctional distancePairs of regions within a networkPairs of regions between networks
XYZ30Are brain networks assortative?
Networks31Are brain networks assortative?
Dorsal attention32Are brain networks assortative?
Ventral attention33Are brain networks assortative?
Default networkDis-assortative34Are brain networks assortative?
Default network: should fragment into several subnetworksDis-assortative35SummaryCharacterize contributions of individual brain regions and networks without using singular task-bound functional attributions
Described quantitative property of networks functional assortativity that can be useful in understanding the functional and compositional similarities and differences between networksA1A2A3NC2NC4NC3NC1Brain areasNeural computationsBehaviorsA4Network 1Network 2Network 3
CognitiveStructure-function mappingPessoa (2008), Nature Reviews Neuroscience37CollaboratorsMichael AndersonJosh KinnisonLucina Uddin
National Institute of Mental Healthemotioncognition.org38