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Tumorous nodules in the native kidney in a woman transplanted 3 years earlier because
of “chronic pyelonephritis”-induced renal failure
B. IvanyiDepartment of Pathology
University of Medicine, Szeged, Hungary
Data retrieved from our files
May 2007: a 54-year-old woman with chronic renal failure due to “bilateral chronic pyelonephritis” received an allograft from a deceased donor
Sept 2007 (protocol Bx): no alteration
May 2008 (protocol Bx): Tac toxicity and acute TMR
July 2010 (Bx for cause): C4d/+/ chronic AMR
Oct 2010: removal of the right native kidney because of tumour at the pyeloureteral border
Tumorous nodules in the pelvis, calyces
Dilated pelvis and calyces
Markedly atrophied medulla and cortex
Tips of the papillae were pale
Gross changes
Papillary tumour in the calyx; fibrotic papilla, atrophied medulla and cortex
The tumour proved invasive urothelial cell carcinoma
Focally, UCC displayed high grade features
The papillae were fibrotic, showed areas of calcification, and were sharply demarcated from the medulla
Hyalinized, structureless papilla; chronic TIN in the medulla
Cortex: obsoleted glomeruli, disappeared/atrophied tubuli
“What would be your diagnosis?”
Our diagnosis
Phenacetin kidney-induced end-stage kidney and multifocal urothelial carcinoma of the pelvis and calyces
The nephrology departments were consulted for a review of the patient’s medical history.
The woman had consumed phenacetin-containing analgesic agents for 15 years (1995-2005) because of headaches and pains due to osteoarthosis.
2005-07: chronic renal insufficiency attributed to phenacetin abuse had ensued; while on the waiting list, the diagnosis of phenacetin kidney had been amended to chronic pyelonephritis.
2007: kidney Tx. The surgeons who regularly controlled the allograft function had not been aware that the woman’s native kidney disease was phenacetin kidney.
2009-2010: painless microhaematuria; the native kidneys had not been scanned by ultrasonography
Sept 2010: admitted to the county hospital with uremic symptoms. Abdominal ultrasonography: a tumour in the right native kidney, which caused hydronephrosis
Oct 2010: removal of the tumorous kidney
April 2011: death because of disseminated cancer
Comment
The association between phenacetin-containing analgesics and the development of urinary tract carcinoma was first reported from Sweden in 1965.
Subsequent studies confirmed that patients with phenacetin kidney were at an increased risk of the development of UCC; the induction time was calculated between 20 and 25 years.
Despite regular tumour screening via urine cytology and abdominal sonography in patients with phenacetin kidney after renal transplantation, the diagnosis of urothelial carcinoma was still made late in many patients.
Comment
The prohibition of phenacetin-containing analgetics led to a significant decrease in the incidence of phenacetin kidney in Hungary,
and a potential long-term consequence of analgesic consumption,
the development of urothelial carcinoma of the urinary tract, has subsequently become exceptional.
The hyalinized, structureless papillae with calcifications led us to the histopathological diagnosis of end-stage kidney due to phenacetin kidney. Our diagnosis was confirmed by the patient’s medical history.
The multifocal urothelial carcinoma was obviously induced by the analgesic abuse.
The presented case is an example of how the pathologist can sometimes put things order.