Tong Ling Interferometric Optophysiology Hansen Experimental Physics Laboratory & Department of Ophthalmology Stanford University 452 Lomita Mall, Room 139, Stanford, CA 94305-4085 Tel: +1 650 (561)-5222 Email: tongling@stanford.edu

RESEARCH INTERESTS Developing high-speed interferometric imaging techniques (quantitative phase microscopy, optical coherence tomography, etc.) for ophthalmic biomedical applications including:

• Full-field interferometric imaging of neural signals • Optoretinogram – In-vivo functional imaging of the human retina • Interferometric thermometry for non-damaging retinal laser therapy • Interferometer-based high-resolution wavefront sensing / diagnosis

EXPERIENCE 2016 - present Postdoctoral Fellow

Advisor: Prof. Daniel Palanker Hansen Experimental Physics Laboratory & Department of Ophthalmology, Stanford University

EDUCATION 2011 - 2016 Ph.D., Optical Engineering

College of Optical Science and Engineering, Zhejiang University

2007 – 2011 B.Eng., Information Engineering Department of Optical Engineering, Zhejiang University

AWARDS and HONORS

2016 Outstanding Graduate Award, Zhejiang Province

2016 Outstanding Graduate Award, Zhejiang University

2015 Wang Daheng Optics Award, Chinese Optical Society

2015 First Prize Scholarship, China Instrument and Control Society

2015 National Scholarship for Graduate Students, Ministry of Education of the People's Republic of China

2015 Graduate of Merit / Triple-A Graduate, Zhejiang University

2014 Cao Guangbiao First Class Scholarship, Zhejiang University

2013 Glarun Group First Class Scholarship, Zhejiang University

2013 Outstanding Graduate Leader Award, Zhejiang University

2012 Sunny Optical Technology Second Class Scholarship, Zhejiang University

PROFESSIONAL SERVICE

Independent journal reviewer for Optics Letters, Optics Express, Applied Optics, Optics Communications, etc.

BOOKS

1. Yongying Yang, Tong Ling, “Novel common-path interferometers,” Zhejiang University Press, Hangzhou, China, funded by the National Fund for Academic Publication in Science and Technology (ISBN: 978-7-308-18571-4).

REFEREED JOURNAL PUBLICATIONS (*equal authorship)

Submitted

1. K. C. Boyle, Z. Chen, T. Ling, V. P. Pandiyan, J. Kuchenbecker, R. Sabesan and D. Palanker, “On mechanisms of light-induced deformations in photoreceptors,” bioRxiv 2020.01.08.897728 (2020).

Published

1. V. P. Pandiyan, A. Maloney-Bertelli, J. Kuchenbecker, K. C. Boyle, T. Ling, Z. C. Chen, B. H. Park, A. Roorda, D. Palanker and R. Sabesan, “The optoretinogram reveals the primary steps of phototransduction in the living human eye,” Science Advances 6, eabc1124 (2020).

2. T. Ling*, K. C. Boyle*, V. Zuckerman, T. Flores, C. Ramakrishnan, K. Deisseroth and D. Palanker, “High-speed interferometric imaging reveals dynamics of neuronal deformation during the action potential,” Proceedings of the National Academy of Sciences (PNAS), Direct submission, 117, 10278-10285 (2020).

3. T. Ling, K. C. Boyle, G. Goetz, P. Zhou, Y. Quan, F. S. Alfonso, T. W. Huang and D. Palanker, “Full-field interferometric imaging of propagating action potentials,” Light: Science & Applications 7, 107 (2018).

4. G. Goetz*, T. Ling*, T. Gupta, S. Kang, J. Wang, P. D. Gregory, B. H. Park, and D. Palanker, “Interferometric mapping of material properties using thermal perturbation,” Proceedings of the National Academy of Sciences (PNAS), Direct submission, 115, E2499-E2508 (2018).

5. R. Zhang, Y. Yang, Z. Liang, J. Jiang, T. Ling, “High-precision calibration method for shear

ratio based on the shearing wavefront feature extraction of a phase plate,” Applied Optics 57, 5121-5129 (2018).

6. T. Ling, J. Jiang, R. Zhang, and Y. Yang, “Quadriwave lateral shearing interferometric microscopy with wideband sensitivity enhancement for quantitative phase imaging in real time,” Scientific Reports 7, 9 (2017).

7. T. Ling, D. Liu, X. Yue, Y. Yang, Y. Shen, and J. Bai, “Quadriwave lateral shearing interferometer based on a randomly encoded hybrid grating,” Optics Letters 40, 2245-2248 (2015).

8. T. Ling, Y. Yang, D. Liu, X. Yue, J. Jiang, J. Bai, and Y. Shen, “General measurement of optical system aberrations with a continuously variable lateral shear ratio by a randomly encoded hybrid grating,” Applied Optics 54, 8913-8920 (2015).

9. X. Yue, Y. Yang, T. Ling, D. Liu, Y. Luo, J. Bai, and Y. Shen, “Design of randomly encoded hybrid grating for wavefront testing by quadriwave lateral shearing interferometry,” Chinese Journal of Lasers 42, 1008006 (2015).

10. Z. Cheng, D. Liu, Y. Yang, T. Ling, X. Chen, L. Zhang, J. Bai, Y. Shen, L. Miao, and W. Huang, "Practical phase unwrapping of interferometric fringes based on unscented Kalman filter technique," Optics Express 23, 32337-32349 (2015).

11. T. Ling, Y. Yang, X. Yue, D. Liu, Y. Ma, J. Bai, and K. Wang, “Common-path and compact wavefront diagnosis system based on cross grating lateral shearing interferometer,” Applied Optics 53, 7144-7152 (2014).

12. T. Ling, D. Liu, Y. Yang, L. Sun, C. Tian, and Y. Shen, “Off-axis cyclic radial shearing interferometer for measurement of centrally blocked transient wavefront,” Optics Letters 38, 2493-2495 (2013).

13. D. Liu, Y. Yang, Z. Cheng, H. Huang, B. Zhang, T. Ling, and Y. Shen, “Retrieval and analysis of a polarized high-spectral-resolution lidar for profiling aerosol optical properties,” Optics Express 21, 13084-13093 (2013).

14. C. Tian, Y. Yang, Y. Zhuo, T. Ling, and H. Li, “Polynomial approximation method for tomographic reconstruction of three-dimensional refractive index fields with limited data,” Optics and Lasers in Engineering 50, 496-501 (2012).

15. C. Tian, Y. Yang, T. Wei, T. Ling, and Y. Zhuo, “Demodulation of a single-image interferogram using a Zernike-polynomial-based phase-fitting technique with a differential evolution algorithm,” Optics Letters 36, 2318-2320 (2011).

16. C. Tian, Y. Yang, Y. Zhuo, T. Wei, and T. Ling, “Tomographic reconstruction of three-dimensional refractive index fields by use of a regularized phase-tracking technique and a polynomial approximation method,” Applied Optics 50, 6495-6504 (2011).

PATENTS 1. Y. Yang, T. Ling, X. Yue, D. Liu, “A randomly encoded hybrid grating based on the restriction

of radiant flux,” China Patent No. 2015 10066327.3, Issued

2. Y. Yang, D. Liu, T. Ling, L. Li, X. Yue, “Scattering microscope for three-dimensional imaging of surface defect on fine optics,” China Patent No. 2014 10294723.7, Issued

3. Y. Yang, T. Ling, C. Tian, L. Sun, Y. Zhuo, “Off-axis cyclic radial shearing interference system and method under centrally blocked circumstance,” China Patent No. 2012 10121717.2, Issued

MEDIA COVERAGE

1. “Researchers design technology that sees nerve cells fire,” by Lesley Earl and Dustin Hays, National Eye Institute, highlighted in EurekAlert!, Phys.org, BioscienceTechnology and Laboratory Equipment.

2. “Watching brain cells fire in real time,” by Nathan Collins, Stanford News, highlighted in The Medical News, EurekAlert!, Science Daily, Long Room and Brinkwire.

3. “Optical technology watches nerve cells fire,” by Lucy Rowlands, Physics World.

INVITED TALKS

1. Tong Ling, “High-speed interferometric imaging of fast nanometer-scale cellular dynamics for all-optical non-invasive electrophysiology,” 1st Seeking-truth Forum of Advanced Photonics, College of Optical Science and Engineering, Zhejiang University, Hangzhou, China, September 2020.

2. Tong Ling, Daniel Palanker, “Full-field interferometric imaging of action potentials,” State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China, May 2019.

3. Tong Ling, Daniel Palanker, “Optophysiology and calorimetry based on quantitative phase imaging,” State Key Laboratory of Modern Optical Instrumentation, Zhejiang University, Hangzhou, China, May 2019.

4. Daniel Palanker, Tong Ling, Kevin C. Boyle, Georges Goetz, “Optophysiology and calorimetry based on quantitative phase imaging,” SPIE Photonics West, San Francisco, CA, February 2019.

5. Tong Ling, “Common-path interferometry and its applications,” School of Communication & Information Engineering, Shanghai University, Shanghai, China, December 2017.

CONTRIBUTED TALKS

1. “Full-field interferometric imaging of neuron deformation during action potential,” Label-free

Biomedical Imaging and Sensing (LBIS), SPIE Photonics West, San Francisco, CA, February 2020.

2. “Quantitative phase imaging of action potentials in mammalian cell culture,” Quantitative Phase Imaging, SPIE Photonics West, San Francisco, CA, February 2019.

3. “Interferometric mapping of material properties using thermal perturbation,” Quantitative Phase Imaging, SPIE Photonics West, San Francisco, CA, January 2018.

4. “Wavefront retrieval for cross-grating lateral shearing interferometer based on differential Zernike polynomial fitting,” Optical Manufacturing and Testing, SPIE Optics+Photonics, San Diego, CA, August 2013.

5. “Development of a field-widened Michelson spectroscopic filter for a polarized near-infrared high spectral resolution lidar,” Lidar Remote Sensing for Environmental Monitoring, SPIE Optics+Photonics, San Diego, CA, August 2013.

6. “Research on reconstruction of spatial density distribution using optical interferometry and tomography,” 6th International Symposium on Advanced Optical Manufacturing and Testing Technologies, Xiamen, China, April 2012.

REFEREED CONFERENCE PUBLICATIONS

1. J. Jiang, T. Ling, Y. Yang, and R. Zhang, "Measurement of optical system aberrations based on randomly encoded hybrid grating," Proc. SPIE 10021, 100210V (2016).

2. R. Zhang, Y. Yang, T. Ling, and J. Jiang, "Improved algorithm of ray tracing in ICF cryogenic targets," Proc. SPIE 10021, 1002111 (2016).

3. T. Ling, D. Liu, Y. Yang, X. Yue, and J. Jiang, "Compact wavefront diagnosis system based on the randomly encoded hybrid grating," Proc. SPIE 9633, 963329 (2015).

4. T. Ling, Y. Yang, D. Liu, X. Yue, and J. Jiang, "Retrieval of phase distributions from the quadriwave lateral shearing interferogram obtained by randomly encoded hybrid grating," Proc. SPIE 9633, 96332G (2015).

5. D. Liu, Y. Yang, X. Chen, T. Ling, L. Zhang, J. Bai, and Y. Shen, "Recent developments of interferometric wavefront sensing," Proc. SPIE 9623, 962303 (2015).

6. T. Ling, D. Liu, L. Sun, Y. Yang, and Z. Cheng, "Wavefront retrieval for cross-grating lateral shearing interferometer based on differential Zernike polynomial fitting," Proc. SPIE 8838, 88380J (2013).

7. L. Sun, D. Liu, T. Ling, and Y. Yang, "Mathematical modeling analysis on a small and compact two-dimensional CGLSI interference system," Proc. SPIE 8840, 88400N (2013).

8. D. Liu, Y. Yang, Z. Cheng, T. Ling, H. Huang, Y. Zhou, Q. Zhang, B. Zhang, and Y. Shen,

"Development of a field-widened Michelson spectroscopic filter for a polarized near-infrared high spectral resolution lidar," Proc. SPIE 8872, 88720L (2013).

9. H. Huang, D. Liu, Y. Yang, Z. Cheng, S. Wang, T. Ling, and Y. Shen, "Design of a field-widened Michelson interferometer for a near-infrared high spectral resolution lidar," Proc. SPIE 8872, 88720P (2013).

10. Z. Cheng, D. Liu, Y. Yang, H. Huang, S. Wang, T. Ling, and Y. Shen, "A spectroscopic transmittance analytical modeling for field-widened Michelson interferometer employed by high spectral resolution lidars," Proc. SPIE 8872, 88720Q (2013).

11. T. Ling, D. Liu, C. Tian, L. Sun, and Y. Yang, "Research on reconstruction of spatial density distribution using optical interferometry and tomography," Proc. SPIE 8420, 84200H (2012).