Ada Doisy Lecturers

1970-71 CharlesHuggins*andElwoodV.Jensen1972-73 PaulBerg*andWalterGilbert*1973-74 SaulRosemanandBruceAmes1974-75 ArthurKornberg*andOsamuHayaishi1976-77 LuisF.Leloir*1977-78 AlbertL.LehningerandEfraimRacker1978-79 DonaldD.BrownandHerbertBoyer1979-80 CharlesYanofsky1980-81 LeroyE.Hood1983-84 JosephL.Goldstein*andMichaelS.Brown*1984-85 JoanSteitzandPhillipSharp*1985-86 StephenJ.BenkovicandJeremyR.Knowles1986-87 TomManiatisandMarkPtashne1988-89 J.MichaelBishop*andHaroldE.Varmus*1989-90 KurtWüthrich1990-91 EdmondH.Fischer*andEdwinG.Krebs*1993-94 BertW.O’Malley1994-95 EarlW.DavieandJohnW.Suttie1995-96 RichardJ.Roberts*1996-97 RonaldM.Evans1998-99 ElizabethH.Blackburn1999-2000 CarlR.WoeseandNormanR.Pace2000-01 WillemP.C.StemmerandRonaldW.Davis2001-02 JanosK.LanyiandSirJohnE.Walker*2002-03 PeterB.MooreandHarryF.Noller

*NobelLaureate

Prion Proteins:One Surprise After Another

Ada Doisy Lectures in BIOCHEMISTRY

Hsp70 Molecular Chaperones:Beyond General Protein Folding

4:00 p.m.Thursday, April 29, 2004Medical Sciences Auditorium

12:00 noonFriday, April 30, 2004

Medical Sciences AuditoriumReception: 11:00 - 11:45 a.m. CLSL-A atrium

Sponsored by the Department of Biochemistry • University of Illinois at Urbana-Champaign

Dr. Elizabeth A.

Department of Biochemistry

University of WisconsinMadison, Wisconsin

20032004

LindquistDr. Susan L.

Whitehead Institute for Biomedical Research

Massachusetts Institute of TechnologyCambridge, Massachusetts

Mitochondrion

Synthesis

Folding

Translocation

Degradation

Craig

Hsp70 Molecular Chaperones:Beyond General Protein Folding

Elizabeth A. Craig

DepartmentofBiochemistryUniversityofWisconsin

Madison,Wisconsin

Thursday,April29,20044:00p.m.

MedicalSciencesAuditorium

Prion Proteins: One Surprise After Another

Susan L. Lindquist

Director,WhiteheadInstituteforBiomedicalResearchMassachusettsInstituteofTechnology

Cambridge,Massachusetts

Friday,April30,200412:00noon

MedicalSciencesAuditorium

In 1970, Dr. EdwardA. Doisy endowed the Ada Doisy Lectures in Biochemistry in honor of his mother. Dr. Doisydescribed his mother as “a kind and gentle woman who wasalways racing her motor in a determined and well-governeddirection toward her objective.” Dr. Doisy noted that she wasdevout in her Baptist beliefs and that “the other god she alsoworshippedsevendaysaweekwasknowledgeandeducation,andsheearlyinculcatedthisadorationintoherchildren.”Healsonoted that she was best remembered for “an inflexible tenacity of purpose, of “stick-to-it-iveness,” and of wrestling with andsolvingproblemsagainstallobstacles.”

Dr. Doisy closely followed the example set by his mother. HereceivedhisBachelor’sdegreein1914andhisMaster’sdegreein 1916 from the University of Illinois. He earned his Ph.D. in1920fromHarvardUniversity.AfterabriefperiodatWashingtonUniversity School of Medicine, he headed the Department ofBiochemistry at St. Louis University School of Medicine untilhis retirement in 1965. Dr. Doisy was the first to isolate and synthesize vitamin K, the vitamin responsible for bloodcoagulation. In 1943 Dr. Doisy received the Nobel Prize inMedicineandPhysiologyinrecognitionofthiswork.

TheinauguralAdaDoisyLectureswereheldinMay1971byNobelLaureateDr.CharlesHugginsandDr.ElwoodJensen.The Doisy Lectures are recognized as the most distinguishedlectureship in Biochemistry at the University of Illinois. Of thefourteenpreviousDoisylecturerswhoareNobelLaureates,ninereceivedtheirPrizeafterservingasDoisyLecturers.ThelistofDoisyLecturersisprintedonthelastpageofthisbrochure.