PROTEINS AND MOLECULAR CHAPERONES

PROTEINS AND MOLECULAR CHAPERONES

Ana María Cano Valencia3rd Semester

Molecular BiologyMarch 09-2015

FOLDING

INTRODUCTION

The proteins are macromolecules that execute almost all the activities of the cells and the

responsibles that all of this occur in the normal way

The protein structure can be primary, secondary, tertiary or quaternary

The molecular chaperones are a diverse group of families of proteins that are requires for the correct folding, transport and degradation of

others proteins in vivo. Are formed for amino acid monomers

Are formed for amino acid monomers

1. “Natural ‘molecular chaperone’ inhibits

Alzheimer’s”Nature Structural & Molecular BiologyTuesday, 17 February 2015

They used tests on mice to show that a human brichos domain can disrupts the catalytic chain reaction associated with

the aggregation of theamyloid-β peptide (Aβ42)

The onset of Alzheimer´s could be delayed with a molecular

chaperone which can inhibits the chain reaction that damages the

brain. The researchers are led by Dr. Samuel Cohen from the

university of cambridge

The researchers are led by Dr. Samuel Cohen from the

university of cambridge

“Natural ‘molecular chaperone’ inhibits

Alzheimer’s”

Which typically appear years before symptoms

such a memory loss

Which typically appear years before symptoms

such a memory loss

This process leads to the dementia.

This process leads to the dementia.


Alzheimer’s”

The mices had been give injections of amyloid proteins in the brain to mimic

the biology of Alzheimer´s

This reduce the level of electrical activity called

“gamma waves” in the brain

When these was injected with Brichos and amyloid

proteins, their gamma wave activity was normal

The findings prove that Alzheimer's devastating impact on memory and personality can be interrupte, however would be difficult to

convert the molecula in a drug.

“A good tactic now is to search for other molecules that have this same highly targeted effect and to see

if these can be used as the starting point for developing a future therapy,” said Cohen.


Alzheimer’s”

The molecular chaperones can help to maintein protein homeostasis by a selectivy

suppressing steps within the complex reaction pathways responsible for thetoxic effects of protein misfolding and

aggregation.

Is difficult that Brichos can be

converted into a drug because it

would be absorbed before work in the

brain

Is difficult that Brichos can be

converted into a drug because it

would be absorbed before work in the

brain

PERSONAL OPINION

I think this topic is very interesting and their applications in the medicine are very extensive , this can be a future solution of a very big amount of diseases, these notices can gift hope for the people

who suffer these type of disease, which every day affect more persons.

Is necessary make more researches of molecular chaperones in the search of find new alternatives for cure many types of diseases.

“The Horrific Dangers Of Protein Powder Consumption“

The protein shakes and smoothies are very popular, these are associated with a

healthy lifestyleAre accesible for all

the rates of age

In the market can be found many types and flavors like chocolate,

vainilla and cand be mixed with a big number options.

Recent studies demonstrate that these protein shakes can have serious health consequences

INQUISITRMarch 1, 2015

“The Horrific Dangers Of Protein Powder Consumption”

The typical protein powder contains 20 to 50 grams of

protein per serving.

Their consumption can

carry to a decrease of the kidney function and a calcium

loss.

Their consumption can

carry to a decrease of the kidney function and a calcium

loss.

In a study reported in 2013

Was found that a increase of amount of protein

caused a increase in urine calcium loss

The researchers use diferents

concentrations of protein (47, 95 and

142 grams per day).


Are the body´s filtration system

A excess of protein increases the kidneys

workload.

Big concentrations Large period time

Can increase the acid load on the kidneys and increase the

risk of kidney stone formation


Many of protein shakes contein heavy metals

Was teste a muscle milk chocolate powder and this

have four heavy metals

Lead levels of 13.5µg

exceed the USP limite of 10µg per day

Cadmium leves was

5.6µg and the USP limit is

5µg per day.

Arsenic and mercury

levels are into USP

limits

The body only can break down 5 to 9 grams of

protein per hour, the excess is

converted to fat or excreted

The body only can break down 5 to 9 grams of

protein per hour, the excess is

converted to fat or excreted

“So it’s a ridiculous waste to be recommending so much more

than you really need.” Kathleen Laquale

PERSONAL OPINION

I think it´s very important know the risk of consumption of these type of products that is consumed in a big amount in the world.

This product is selling with the idea that are healthy, but a little part of population know the real health consequences of their consume, this products lead a big deterioration in the kidneys and these organs are

very important for the life and for a good quality of this.

I think is necessary make more studies of this topic and show this to all the people, for make a responsibility consumption of this products.

MEDICAL UTILITY OF PROTEINS AND MOLECULAR

CHAPERONES

Molecular chaperones are involved in the pathogenesis

of a extensive number of pathologies, like Parkinson, alzheimer and Huntington so these proteins could be

an important pharmacological target


CHAPERONES

Proteins in our body are used for diagnosis of diseases, these can be measured in

serum as CRP for mesure the risk of a CV event or in urine

like the albumin, according to their levels may indicate a

specific pathology or a type of pathologies


CHAPERONES

Knowing the structure of protein hormones can lead

to modification of their amino acid sequences to

improve their pharmacological effects, as in the case of biosynthetic

insulin


CHAPERONESCurrently are developing a lot of technological advancements in relation with proteins, such is the case of antifreeze proteins that can be used

to preserve organs and tissues for transplantation

REFERENCES

• Cohen S I A, et al. A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers. Nature Structural & Molecular Biology, Tuesday, 17 February 2015. Retrieved March 8, 2015 from http://www.onmedica.com/NewsArticle.aspx?id=1f1e86ca-197b-4815-ac4f-5b326d845d68

• INQUISTIR. (2015). The Horrific Dangers Of Protein Powder Consumption. March 1, 2015. Retrieved March 8, 2015 from http://www.inquisitr.com/1885022/the-horrific-dangers-of-protein-powder-consumption/#oK8fzcScv2kwDzPX.99

• Martínez Sánchez, Lina María; Vargas Grisales, Natalia; Toro Montoya, Andrés Eduardo; Pamplona Sierra, Ana Paulina; Queveda Orrego, Esteban. “Biología molecular”. 7. ed. Medellín, Colombia. Editorial Universidad Pontificia Bolivariana, 2014. pp: 112-120

• Images from www.google.com

Science

PROTEINS AND MOLECULAR CHAPERONES