The ONCOLOGY GroupThe Cornerstone of Cancer Care for Your Marketing Plans

Cancer Vaccines: A New Frontier in Prevention and TreatmentOncology nurses can reduce barriers to uptake of preventive vaccines and may increase patients’ acceptance of therapeutic ones.

N U R S E E D I T I O N

OCTOBER 2007VOLUME 21 • NUMBER 11

A CMPMedica Publication©

NURSES • NURSE PRACTITIONERS • PHYSICIAN ASSISTANTS

Beyond Tired: Cancer Fatigue Interventions

New Options for Myelodysplastic Syndromes

ESAs in Anemia: New Data Yield New Insights

To earn continuing education credit/contact hours, go online towww.cancernetwork.com/cme

PLUS — HIGH RISK AND SECONDARY BREAST CANCER, PSYCHIATRIC CONSULTATION, FEBRILE NEUTROPENIA, HDAC INHIBITORS

Cover_ajl.indd 2 10/04/2007 2:50:53 PM

journals • Custom publishing • patient information • online

The Cornerstone of Cancer Care for Your Marketing Plans

Nurse EditionPractical review articles coupled with brief commentaries and useful departments and bilingual patient education tears outs make this limited sponsored quarterly journal an essential read and tool for oncology nurses and physician assistants.

93% of oncology nurses surveyed report the ONCOLOGY Nurse Edition is valuable.Source: Oncology Nurse Post Test September 2006

Cancer Vaccines: A New Frontier in Prevention and TreatmentOncology nurses can reduce barriers to uptake of preventive vaccines and may increase patients’ acceptance of therapeutic ones.

N U R S E E D I T I O N

OCTOBER 2007VOLUME 21 • NUMBER 11

A CMPMedica Publication

NURSES • NURSE PRACTITIONERS • PHYSICIAN ASSISTANTS

Beyond Tired: Cancer Fatigue Interventions

New Options for Myelodysplastic Syndromes

ESAs in Anemia: New Data Yield New Insights

To earn continuing education credit/contact hours, go online towww.cancernetwork.com/cme

PLUS — HIGH RISK AND SECONDARY BREAST CANCER, PSYCHIATRIC CONSULTATION, FEBRILE NEUTROPENIA, HDAC INHIBITORS

Cover_ajl.indd 2 10/04/2007 2:50:53 PM

The Oncology Group

The Oncology Group’s scope and experience with multimedia communications and programs is unparalleled. Let The Oncology Group’s extensive offerings in all mediums serve as the foundation for your marketing plans. For over twenty years, The Oncology Group has been serving the information and education needs and interests of clinicians and patients.

A journal featuring clinical and practical review articles in medical, hematological, surgical and radiation oncology

with solicited articles by leading authorities supplemented by two to three peer-reviewed commentaries. ONCOLOGY reaches 29,852 cancer clinicians monthly with two special issues in April and November and the ASCO Desk Reference in August for a total of fifteen issues in 2008.

ONCOLOGY is listed in seven databases, including Index Medicus.

Novel Therapeutic Avenuesin Myeloma: Changingthe Treatment Paradigm

Reviewed by Sagar Lonial; and Shaji Kumar and Robert A. Kyle

Lessons Learned FromPediatric Cancers:Dramatic Progress, New Challenges

Reviewed by Robert J. Arceci

Rates of Synchronous vsMetachronous Metastases:Analysis of SEER Data

Reviewed by Adam C. Berger and Elin Sigurdson

Managing Cancer in the Older Patient:Cost Considerations

Reviewed by Gary H. Lyman; and Ambuj Kumar and Benjamin Djulbegovic

JUNE 2007 VOLUME 21 • NUMBER 7

For ONCOLOGY on the Web, visit www.cancernetwork.com

A CMPMedica Publication©

Plus Second Opinion: Intracystic Papillary Carcinoma of the Breast and

Closing Thoughts: ASCO Plenary Top 5

Full contents on pages 764, 767, and 770

Joanne GhobrialIrene M. GhobrialPaul Richardsonand colleaguesDana-Farber Cancer Institute

Lisa M. McGregorMonika L. MetzgerVictor M. Santanaand colleaguesUniversity of TennesseeHealth Science Center

Yavuz AnacakJeff J. MeyerLawrence B. MarksDuke University Medical School

June M. McKoyBeatrice J. EdwardsCharles L. Bennettand colleaguesNorthwestern University Feinberg School of Medicine

Cancer Management: A Multidisciplinary Approach

A fixture in clinician’s office, hands and pockets, this comprehensive ready reference is a blueprint to the diagnosis, management and treatment of cancer. The discussion of each disease site combines the perspectives of medical oncology, surgical oncology and radiation oncology in one source. The 11th Edition will be mailed to oncologists and hematologists in the

fall of 2008 and will be available and promoted on CancerNetwork.com.

95.5% of respondents rate the quality of the Cancer Management Handbook as good or excellent.Source: 2007 Cancer Management Handbook Survey

TENTH EDITION, 2007–2008

CancerManagement:A MultidisciplinaryApproachMedical, Surgical, & Radiation Oncology

Edited by

Richard Pazdur, MDUS Food and Drug Administration

Lawrence R. Coia, MDSaint Barnabas Health Care System

William J. Hoskins, MDCurtis and Elizabeth Anderson Cancer Institute

Lawrence D. Wagman, MDCity of Hope National Medical Center

And the publishers of the journal ONCOLOGY

06-07 HB Cove testr.pmd 05/02/2007, 4:38 PM2

The companion website to The Oncology Group publications and programs has 25,911 registered users and an array of resources and products for cancer clinicians and patients.

INTEGRATED COMMUNICATIONS FOR: TRIALS • CLINICIANS • PATIENTS • INTERACTIVE

Oncology NEWS International is a news tabloid guided by an editorial board of thirty one clinicians that is mailed to 26,831 cancer clinicians monthly. The news format and meeting coverage of hematology and oncology combined with the global perspectives and analysis makes this an engaging and well-read publication.

Putting fertility issues on the back burner should no longer be an option for oncolo-gists who treat young adult cancer patients, especially as newer fertility preservation options become available, a number of re-productive medicine specialists told ONI.

Fertility preservation is a complex issue, especially given how quickly reproductive medicine evolves. Experts in the � eld have ramped up e� orts to bridge the gap be-tween cancer care professionals and fertility specialists, even proposing the creation of a new subspecialty called oncofertility. [See poll question on page 2 and on www.cancernetwork.com.]

No time for fertility

In 2002, Leslie Schover, PhD, professor of behavioral science at M.D. Anderson Cancer Center, and her colleagues conduct-ed a survey on oncologists’ attitude toward sperm banking before cancer treatment. Cancer specialists at M.D. Anderson and the Cleveland Clinic participated.

According to the results, nearly all of those surveyed agreed that sperm banking should be o� ered to all eligible men. But only 10% of the respondents reported actu-ally doing so. � e most common reasons for not discussing sperm banking included the presence of advanced disease that re-quired immediate treatment, patients with a poor prognosis of survival, and a lack of time in a busy practice.

While Dr. Schover’s group acknowl-edged that the study was small and the response rate to their survey was low, they believe it still re� ects “oncologists’ failure to give cancer-related infertility adequate consideration…physicians perceive the most common barriers to sperm banking to be a lack of time.”

In addition, they said, “men who have very aggressive disease…are also apt to be excluded from discussion of sperm bank-ing…however, our knowledge test suggests that many oncologists are unaware that sperm banking no longer has to delay can-

“”

V. Craig Jordan, OBE, PhD, DSc, widely known as “ The Father of Tamoxifen,” col-lects the artifacts of war: guns and swords and medals (see photographs on page 8). In fact, in his younger years, he served in the elite SAS (Special Air Service) unit of the British Army. Speaking with ONI at his o� ce at Fox Chase Cancer Center in Philadelphia, Dr. Jordan reminisced about his maternal grandfather, an old army o� cer who railed against the evils of war, but told young Craig to be prepared—war will come again.

Sitting below a picture of himself and Princess Diana, Dr. Jordan cocked his wrist, o� ering the regimental motto on his cuf-� inks: “Who Dares Wins.”

Oncologists must make time for fertility issues

MASTERS OF HEMATOLOGY AND ONCOLOGY:

Father of tamoxifen a Brit to the coreNo one else was interested in antiestrogens when a young Army Captain earned his PhD.

BY RONALD PIANA

QUOTE OF THE MONTH:

SCOTT M. LIPPMAN, MD—CHEMOPREVENTION OF POLYPS NOW A REALITY: VANTAGE POINT—PAGE 12

With these two trials, I think the phoenix is rising . . . . � e concept of chemoprevention is alive and well.

I N S I D EMAY 2008 • VOLUME 17 • NUMBER 5

POINT/COUNTERPOINTFinasteride for chemoprevention of prostate cancer: Is anyone using it?

JUDD MOUL, MD DEREK RAGHAVAN, MD

BREAST CANCERMammography screening in older women stirs controversy Study suggesting benefi t termed ‘fl at-out wrong’ by one critic.

Moderate drinking increases risk of ER+/PR+ breast cancer

‘Our fi ndings fi t with existing data from other studies, but ours is the largest study to date.’

JASMINE LEW

LUNG CANCEREnd of an era of “desperate” therapies for small-cell lung cancer

PAUL BUNN, JR., MD

HEMATOLOGYIntensive imatinib a ‘home run’ in pediatric Ph+ ALL

DIAGNOSTIC DILEMMA

QUIZ

Gastric jejunal histology

A ‘NEW LOOK’ FOR ONI Your favorite cancer news publication gets a make over

TWO-STAGE HEPATECTOMY FOR ‘UNRESECTABLE’ LIVER METS Good results from France

V. CRAIG JORDAN, MD

CONTINUED ON PAGE 26CONTINUED ON PAGE 8

To provide fertility services without provoking turf wars may require creation of a new oncofertility subspecialty—a professional who bridges three disciplines: OB/GYN, urology, and oncology.

BY SHALMALI PAL

FEATURE:

A fl ap over fl at polyps CONTINUED ON PAGE 21

GLOBAL PERSPECTIVE

AND ANALYSIS OF

DEVELOPMENTS IN

HEMATOLOGY

AND ONCOLOGY

A CMPMedica Publication www.cancernetwork.com Editor-in-Chief Steven Rosen, MD

Visit us on the web:

I N T E R N A T I O N A L

From the Publishers of the Journal ONCOLOGY

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30

34

46

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What is causing this patient’s anemia?

Belly BandsWrap your message abound an issue of Oncology NEWS International and increase your exposure. Reserve a bellyband in May and November and receive bonus distribution at ASCO and SABCS.

The Cornerstone of Cancer Care for Your Marketing Plans

Custom PublishingThe Oncology Group offers publications and E-initiatives from clinical to application.

Wall ChartsThese counseling tools for clinicians can review side effects or present decision trees or dosing guides in a manageable and easy to reference format and can be distributed with any of The Oncology Group publications and posted online.

Your company logo is clearly indicated as the sponsor.

INTEGRATED COMMUNICATIONS FOR: TRIALS • CLINICIANS • PATIENTS • INTERACTIVE

Communications Medium Publication Content

Supplements Print & Online ONCOLOGY Research Reviews, Meeting Proceedings, Roundtables

Supplements Print & Online Oncology NEWS International Hot Topics, E Reporters, Reviews, Pro/Con Papers

Supplements Print & Online Oncology NEWS International Practice Management, Cancer Care Policy

Supplements Print & Online ONCOLOGY Nurse Edition Papers, Research, Meeting Notes, Roundtables

Wall Charts Print & Online All Oncology Group Products

Patient Education Print & Online All Oncology Group Products

Clinical Trial Outsert Print & OnlineOncology NEWS International CancerNetwork.com

Promote and recruit for clinical trials

E-Initiatives/Newsletters Online CancerNetwork.com News Briefs, Interviews, Abstracts, Research, Perspectives

Physicians Guides Print All Oncology Group Products

Multimedia News Release Online CancerNetwork.com

Podcasts Online CancerNetwork.com

Slide Shows Online CancerNetwork.com

NEW

TREATMEN

T PARADIGM

S IN REN

AL CELL CARCINO

MA

Ronald M. Bukowski, MDCleveland Clinic Foundation Taussig Cancer Center

Cleveland Clinic Foundation Lerner College of Medicine of CWRU

New Treatment Paradigmsin Renal Cell Carcinoma

COABFrom the publishers of ONCOLOGY

The Oncology Group

Supported by an educational grant from

3CME

Bukowski_cvr 10/3/07 10:40 AM Page 1

Cutaneous T-CellLymphomas

A Guide for the Community Oncologist

Steven T. Rosen, MD, and Christiane Querfeld, MD

Timothy M. Kuzel, MD, and Joan Guitart, MD

Feinberg School of MedicineNorthwestern University, Chicago, Illinois

A Supplement to

OCTOBER 2007 VOL 21 • NO 11 • SUPPLEMENT NO 5

For ONCOLOGY on the Web, visit www.cancernetwork.com

With presentations by

A CMPMedica Publication

Edith P. Mitchell, ��, ����Roman Perez-Soler, ��

Eric Van Cutsem, ��, � �and Mario E. Lacouture, ��

Roman Perez-Soler, ��and Eric Van Cutsem, ��, � �

Mario E. Lacouture, ��Jonathan Cotliar, ��

and Edith P. Mitchell, ��, ����

Siegfried Segaert, ��, � �and Eric Van Cutsem, ��, � �

Naoya Yamazaki, ��and Kei Muro, ��

Michelle Purdom, ��and Aki Ohinata, ��, ��-�

Lew Iacovelli, � �, ����, ���

Lynne Wagner, � �and Mario E. Lacouture, ��

Dermatologic Toxicities Associated With EGFR-Inhibitor Therapies

Mario E. Lacouture, ��Robert H. Lurie

Comprehensive Cancer Centerat Northwestern University

Roman Perez-Soler, ��Albert Einstein

College of Medicine

Guest Editors

Funding for this supplement was provided by Amgen

Putting fertility issues on the back burner should no longer be an option for oncolo-gists who treat young adult cancer patients, especially as newer fertility preservation options become available, a number of re-productive medicine specialists told ONI.

Fertility preservation is a complex issue, especially given how quickly reproductive medicine evolves. Experts in the � eld have ramped up e� orts to bridge the gap be-tween cancer care professionals and fertility specialists, even proposing the creation of a new subspecialty called oncofertility. [See poll question on page 2 and on www.cancernetwork.com.]

No time for fertility

In 2002, Leslie Schover, PhD, professor of behavioral science at M.D. Anderson Cancer Center, and her colleagues conduct-ed a survey on oncologists’ attitude toward sperm banking before cancer treatment. Cancer specialists at M.D. Anderson and the Cleveland Clinic participated.

According to the results, nearly all of those surveyed agreed that sperm banking should be o� ered to all eligible men. But only 10% of the respondents reported actu-ally doing so. � e most common reasons for not discussing sperm banking included the presence of advanced disease that re-quired immediate treatment, patients with a poor prognosis of survival, and a lack of time in a busy practice.

While Dr. Schover’s group acknowl-edged that the study was small and the response rate to their survey was low, they believe it still re� ects “oncologists’ failure to give cancer-related infertility adequate consideration…physicians perceive the most common barriers to sperm banking to be a lack of time.”

In addition, they said, “men who have very aggressive disease…are also apt to be excluded from discussion of sperm bank-ing…however, our knowledge test suggests that many oncologists are unaware that sperm banking no longer has to delay can-

“”

V. Craig Jordan, OBE, PhD, DSc, widely known as “ The Father of Tamoxifen,” col-lects the artifacts of war: guns and swords and medals (see photographs on page 8). In fact, in his younger years, he served in the elite SAS (Special Air Service) unit of the British Army. Speaking with ONI at his o� ce at Fox Chase Cancer Center in Philadelphia, Dr. Jordan reminisced about his maternal grandfather, an old army o� cer who railed against the evils of war, but told young Craig to be prepared—war will come again.

Sitting below a picture of himself and Princess Diana, Dr. Jordan cocked his wrist, o� ering the regimental motto on his cuf-� inks: “Who Dares Wins.”

Oncologists must make time for fertility issues

MASTERS OF HEMATOLOGY AND ONCOLOGY:

Father of tamoxifen a Brit to the coreNo one else was interested in antiestrogens when a young Army Captain earned his PhD.

BY RONALD PIANA

QUOTE OF THE MONTH:

SCOTT M. LIPPMAN, MD—CHEMOPREVENTION OF POLYPS NOW A REALITY: VANTAGE POINT—PAGE 12

With these two trials, I think the phoenix is rising . . . . � e concept of chemoprevention is alive and well.

I N S I D EMAY 2008 • VOLUME 17 • NUMBER 5

POINT/COUNTERPOINTFinasteride for chemoprevention of prostate cancer: Is anyone using it?

JUDD MOUL, MD DEREK RAGHAVAN, MD

BREAST CANCERMammography screening in older women stirs controversy Study suggesting benefi t termed ‘fl at-out wrong’ by one critic.

Moderate drinking increases risk of ER+/PR+ breast cancer

‘Our fi ndings fi t with existing data from other studies, but ours is the largest study to date.’

JASMINE LEW

LUNG CANCEREnd of an era of “desperate” therapies for small-cell lung cancer

PAUL BUNN, JR., MD

HEMATOLOGYIntensive imatinib a ‘home run’ in pediatric Ph+ ALL

DIAGNOSTIC DILEMMA

QUIZ

Gastric jejunal histology

A ‘NEW LOOK’ FOR ONI Your favorite cancer news publication gets a make over

TWO-STAGE HEPATECTOMY FOR ‘UNRESECTABLE’ LIVER METS Good results from France

V. CRAIG JORDAN, MD

CONTINUED ON PAGE 26CONTINUED ON PAGE 8

To provide fertility services without provoking turf wars may require creation of a new oncofertility subspecialty—a professional who bridges three disciplines: OB/GYN, urology, and oncology.

BY SHALMALI PAL

FEATURE:

A fl ap over fl at polyps CONTINUED ON PAGE 21

GLOBAL PERSPECTIVE

AND ANALYSIS OF

DEVELOPMENTS IN

HEMATOLOGY

AND ONCOLOGY

A CMPMedica Publication www.cancernetwork.com Editor-in-Chief Steven Rosen, MD

Visit us on the web:

I N T E R N A T I O N A L

From the Publishers of the Journal ONCOLOGY

2

30

34

46

21

36

7

53

What is causing this patient’s anemia?

AdvERTISE HERE

Patient Information

Contact: Claudia Shayne Ferguson, 914.522.3188/cshayneferguson@gmail.comChrissy Sheehan, 201.984.6269/chrissy.sheehan@cmpmedica.comAmy Birnbach, 201.984.6265/amy.birnbach@cmpmedica.comKathy Mischak, 415.874.4573/kathy.mischak@cmpmedica.comBeth Scholz, 215.297.9327/beth.scholz@cmpmedica.com

A Step-by-Step Guide to Breast Self-ExaminationA fully illustrated breast self exam brochure.

Patient EducationAnswer patient’s questions and help clinicians and caregivers sort through the maze of information and emotions by supporting a DVD with The Oncology Group.

Myths & Facts and Understanding SeriesThese disease specific patient booklets serve as a “what you need to know” guide to assist clinicians and patients. Providing a comprehensive assessment of the disease, patient perspectives and common misconceptions, these publications act as a blueprint for clinicians, patients and caregivers.

These publications can be translated into other languages and distributed at conventions, through starter kits, online, advocacy groups, The Oncology Group and your sales force.

HYC388R0

JOHN R. ECKARDT, MDJULIA E. KIMMIS, RN, BC, FNP-C, AOCN

The Center for Cancer Care and ResearchSt. Louis, Missouri

Comprender elcáncer de pulmónGuía para los pacientes y sus familias

Comprender elcáncer de pulmón

Oncology Publishing Group

HYC382R0

Con el apoyo de una subvención educativa sin restricciones de

JOHN ECKARDT, MDJULIA E. KIMMIS, RN, BC, FNP-C, AOCN

The Center for Cancer Care and ResearchSt. Louis, Missouri

Understanding

Lung Cancer

A Guide for Patients and Their Families

UnderstandingLung Cancer

The Oncology Group is a division of CMPMedica.CMPMedica publications reach over 500,000 clinicians and the organization is committed to quality content and unbiased journalism. Special projects are considered an extension of the journal and are held to the same standards as articles that are featured in the host publication. Editorial integrity is a cornerstone of The Oncology Group publications and projects.

Communications Medium Publication Content

Patient Education Print & Online ONCOLOGY & ONCOLOGY Nurse Edition Perforated Bilingual Counseling Aids

Patient Literature Print & Online Myths & Facts & Understanding Series “What you need to know” guide on specific topics

dvd and video Print & Online CancerNetwork.com/Oncology NEWS International Clinician, Patient and Caregivers interviews and advice

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