The Journal of

PHARMACOLOGYAnd Experimental Therapeutics

A Publication of the American Society for Pharmacology and Experimental Therapeutics

December 2013 Vol. 347, No. 3

Contents

HIGHLIGHTED PAPERS 541

PERSPECTIVES IN PHARMACOLOGY

Nonhuman Primates: Translational Models for Predicting Antipsychotic-Induced Movement Disorders 542Roger D. Porsolt, Vincent Castagné, Eric Hayes, and David Virley

BEHAVIORAL PHARMACOLOGY

Differential Long-Term Effects of Haloperidol and Risperidone on the Acquisition and Performance of Tasks of SpatialWorking and Short-Term Memory and Sustained Attention in Rats

547

Elizabeth J. Hutchings, Jennifer L. Waller, and Alvin V. Terry, Jr.

Effect of Delay on Self-Administration of Remifentanil under a Drug Versus Drug Choice Procedure in Rhesus Monkeys 557David R. Maguire, Lisa R. Gerak, and Charles P. France

Dopamine b-Hydroxylase Inhibitors Enhance the Discriminative Stimulus Effects of Cocaine in Rats 564Daniel F. Manvich, Lauren M. DePoy, and David Weinshenker

CARDIOVASCULAR

Atorvastatin-Loaded Hydrogel Affects the Smooth Muscle Cells of Human Veins 574Céline Dubuis, Laurence May, Florian Alonso, Ludmila Luca, Ioanna Mylonaki, Paolo Meda, Florence Delie,Olivier Jordan, Sébastien Déglise, Jean-Marc Corpataux, François Saucy, and Jacques-Antoine Haefliger

CELLULAR AND MOLECULAR

The Effects of an Inhibitor of Diglyceride Lipase on Collagen-Induced Platelet Activation 582Elke C. G. Jackson, Giorgio Ortar, and Archie McNicol

Pharmacological Distinction between Soluble and Transmembrane Adenylyl Cyclases 589Jacob L. Bitterman, Lavoisier Ramos-Espiritu, Ana Diaz, Lonny R. Levin, and Jochen Buck

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

S Translational Studies of Phenotypic Probes for the Mononuclear Phagocyte System and Liposomal Pharmacology 599Whitney P. Caron, John C. Lay, Alan M. Fong, Ninh M. La-Beck, Parag Kumar, Suzanne E. Newman, Haibo Zhou,Jane H. Monaco, Daniel L. Clarke-Pearson, Wendy R. Brewster, Linda Van Le, Victoria L. Bae-Jump, Paola A. Gehrig,and William C. Zamboni

Effect of Nitric Oxide on the Anticancer Activity of the Topoisomerase-Active Drugs Etoposide and Adriamycin in HumanMelanoma Cells

607

Birandra K. Sinha, Ashutosh Kumar, Suchandra Bhattacharjee, Michael G. Espey, and Ronald P. Mason

DRUG DISCOVERY AND TRANSLATIONAL MEDICINE

Linking Phenotype to Kinase: Identification of a Novel Benzoxaborole Hinge-Binding Motif for Kinase Inhibition andDevelopment of High-Potency Rho Kinase Inhibitors

615

Tsutomu Akama, Chen Dong, Charlotte Virtucio, David Sullivan, Yasheen Zhou, Yong-Kang Zhang, Fernando Rock,Yvonne Freund, Liang Liu, Wei Bu, Anne Wu, Xiao-Qing Fan, and Kurt Jarnagin

cGMP-Selective Phosphodiesterase Inhibitors Stimulate Mitochondrial Biogenesis and Promote Recovery from AcuteKidney Injury

626

Ryan M. Whitaker, Lauren P. Wills, L. Jay Stallons, and Rick G. Schnellmann

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S Combined Analysis of Pharmacokinetic and Efficacy Data of Preclinical Studies with Statins Markedly ImprovesTranslation of Drug Efficacy to Human Trials

635

E. van de Steeg, R. Kleemann, H. T. Jansen, W. van Duyvenvoorde, E. H. Offerman, H. M. Wortelboer, and J. DeGroot

Kinetics of 5-HT2B Receptor Signaling: Profound Agonist-Dependent Effects on Signaling Onset and Duration 645David J. Unett, Joel Gatlin, Todd L. Anthony, Daniel J. Buzard, Steve Chang, Chuan Chen, Xiaohua Chen, HuongT.-M. Dang, John Frazer, Minh K. Le, Abu J. M. Sadeque, Charles Xing, and Ibragim Gaidarov

Establishment of an X-ray Irradiation-Induced Glossitis Model in Rats: Biphasic Elevation of Proinflammatory Cytokinesand Chemokines

660

Takako Nakashima, Naoya Uematsu, Masafumi Shibamori, Kazushi Sakurai, and Tatsuhiro Ishida

S Pharmacologic Profiling of Phosphoinositide 3-Kinase Inhibitors as Mitigators of Ionizing Radiation–Induced Cell Death 669John S. Lazo, Elizabeth R. Sharlow, Michael W. Epperly, Ana Lira, Stephanie Leimgruber, Erin M. Skoda, Peter Wipf,and Joel S. Greenberger

Differential Interaction of Neuroleptics with Apomorphine-Induced Behavior in Rats as a Function of Changing Levels ofDopamine Receptor Stimulation

681

Anton A.H.P. Megens, Herman M.R. Hendrickx, Hilde Lavreysen, and Xavier Langlois

The Protease Activated Receptor 2 (PAR2) Polymorphic Variant F240S Constitutively Activates PAR2 Receptors andPotentiates Responses to Small-Molecule PAR2 Agonists

697

Jian-Nong Ma and Ethan S. Burstein

Molecular Pharmacology and Ligand Docking Studies Reveal a Single Amino Acid Difference between Mouse andHuman Serotonin 5-HT2A Receptors That Impacts Behavioral Translation of Novel 4-Phenyl-2-dimethylaminotetralinLigands

705

Clinton E. Canal, Tania Cordova-Sintjago, Yue Liu, Myong S. Kim, Drake Morgan, and Raymond G. Booth

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

Role of Angiotensin-(1–7) in Gastroprotection against Stress-Induced Ulcerogenesis. The Involvement of Mas Receptor,Nitric Oxide, Prostaglandins, and Sensory Neuropeptides

717

Marcin Magierowski, Katarzyna Jasnos, Michal Pawlik, Gracjana Krzysiek-Maczka, Agata Ptak-Belowska,Rafal Olszanecki, Slawomir Kwiecien, Ryszard Korbut, and Tomasz Brzozowski

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

Hepatic Basolateral Efflux Contributes Significantly to Rosuvastatin Disposition I: Characterization of Basolateral VersusBiliary Clearance Using a Novel Protocol in Sandwich-Cultured Hepatocytes

727

Nathan D. Pfeifer, Kyunghee Yang, and Kim L. R. Brouwer

Hepatic Basolateral Efflux Contributes Significantly to Rosuvastatin Disposition. II: Characterization of HepaticElimination by Basolateral, Biliary, and Metabolic Clearance Pathways in Rat Isolated Perfused Liver

737

Nathan D. Pfeifer, Arlene S. Bridges, Brian C. Ferslew, Rhiannon N. Hardwick, and Kim L.R. Brouwer

S Impact of Nicotine Metabolism on Nicotine’s Pharmacological Effects and Behavioral Responses: Insights from aCyp2a(4/5)bgs-Null Mouse

746

Lei Li, Kunzhi Jia, Xin Zhou, Sarah E. McCallum, Lindsay B. Hough, and Xinxin Ding

Pharmacokinetic Assessment of Efflux Transport in Sunitinib Distribution to the Brain 755Rajneet K. Oberoi, Rajendar K. Mittapalli, and William F. Elmquist

NEUROPHARMACOLOGY

Nerve Injury Increases GluA2-Lacking AMPA Receptor Prevalence in Spinal Cords: Functional Significance andSignaling Mechanisms

765

Shao-Rui Chen, Hong-Yi Zhou, Hee Sun Byun, and Hui-Lin Pan

The Delta-Opioid Receptor Is Sufficient, but Not Necessary, for Spinal Opioid-Adrenergic Analgesic Synergy 773Anne-Julie Chabot-Doré, Magali Millecamps, and Laura S. Stone

S Carbimazole Is an Inhibitor of Protein Synthesis and Protects from Neuronal Hypoxic Damage In Vitro 781Cornelius Lehane, Timo Guelzow, Simone Zenker, Anika Erxleben, Christian I. Schwer, Bernd Heimrich,Hartmut Buerkle, and Matjaz Humar

Spinal-Supraspinal and Intrinsic m-Opioid Receptor Agonist-Norepinephrine Reuptake Inhibitor (MOR-NRI) Synergy ofTapentadol in Diabetic Heat Hyperalgesia in Mice

794

Thomas Christoph, Wolfgang Schröder, Ronald J. Tallarida, Jean De Vry, and Thomas M. Tzschentke

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Purinergic P2X7 Receptors Mediate Cell Death in Mouse Cerebellar Astrocytes in Culture 802Elvira Salas, Luz María G. Carrasquero, Luis A. Olivos-Oré, Diego Bustillo, Antonio R. Artalejo, Maria TeresaMiras-Portugal, and Esmerilda G. Delicado

ERRATUM

Correction to “Menthol Inhibits 5-HT3 Receptor–Mediated Currents” 816

S Supplemental material is available online at http://jpet.aspetjournals.org.

About the cover: Immunofluorescence image of a mouse cerebellar astrocyte stained with anti-GFAP-FITC and anti-P2X7 receptor-Cy3antibodies. See article by Salas et al. on p. 802 of this issue.

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