PHARMACOLOGYPHARMACOLOGYThe Journal of

And Experimental Therapeutics

A Publication of the American Society for

Pharmacology and Experimental Therapeutics

Volume 336 ■ Number 2 ■ February 2011 ■ ISSN 0022-3565

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PLANNED TABLE OF CONTENTS:

• A 40-Year Journey in Search of Selective Antiviral Chemotherapy, Erik De Clercq

• microRNAs: Master Regulators as Potential Therapeutics in Cancer, Michela Garofalo, Carlo M. Croce

• Physiologically-Based Pharmacokinetics in Drug Development and Regulatory Science, Malcolm Rowland, Carl Peck, Geoffrey Tucker

• Transcriptional and Epigenetic Regulation of Opioid Receptor Genes: Present and Future, Li-Na Wei, Horace H. Loh

• Membrane Receptor for Thyroid Hormone: Physiologic and Pharmacologic Implications, Paul J. Davis, Faith B. Davis, Shaker A. Mousa, Mary K. Luidens, Hung-Yun Lin

• Strategies to Discover Unexpected Targets for Drugs Active at G Protein–Coupled Receptors, John A. Allen, Bryan L. Roth

• Bioactivation of Drugs: Risk and Drug Design, John S. Walsh, Gerald T. Miwa

• Hydrogen Sulfi de and Cell Signaling, Ling Li, Peter Rose, Philip K. Moore

• Schizophrenia: Treatment Targets Beyond Monoamine Systems, Hisham M. Ibrahim, Carol A. Tamminga

• Modulation of Monoamine Receptors by Adaptor Proteins and Lipid Rafts: Role in Some Effects of Centrally Acting Drugs and Therapeutic Agents, Karl Björk, Per Svenningsson

• Orexin Receptors: Pharmacology and Therapeutic Opportunities, Thomas E. Scammell, Christopher J. Winrow

• Macrophages and Tissue Injury: Agents of Defense or Destruction? Debra L. Laskin, Vasanthi R. Sunil, Carol R. Gardner, Jeffrey D. Laskin

• Drugging the Cancer Stem Cell Compartment: Lessons Learned from the Hedgehog and Wnt Signal Transduction Pathways, Michael E. Dodge, Lawrence Lum

• Mechanisms of the Anti-Cancer and Anti-Infl ammatory Actions of Vitamin D, Aruna V. Krishnan, David Feldman

• Spatiotemporal Regulation of Small GTPases as Revealed by Probes Based on the Principle of Förster Resonance Energy Transfer (FRET): Implications for Signaling and Pharmacology, Etsuko Kiyokawa, Kazuhiro Aoki, Takeshi Nakamura, Michiyuki Matsuda

• Mechanisms of Monoclonal Antibody–Drug Interactions, Honghui Zhou, Mary Ann Mascelli

• Molecular Mechanisms and Treatment Options for Muscle Wasting Diseases, Markus A. Rüegg, David J. Glass

• Curing HIV: Pharmacologic Approaches to Target HIV-1 Latency, Shailesh K. Choudhary, David M. Margolis

Annual Review of Pharmacology and ToxicologyVolume 51 • February 2011 • Online & In Print • http://pharmtox.annualreviews.org

Editor: Arthur K. Cho, University of California, Los Angeles

The Annual Review of Pharmacology and Toxicology, in publication since 1961, covers the significant developments in the fields of pharmacology and toxicology, including receptors, transporters, enzymes, and chemical agents; drug development science; systems such as the immune system, central and autonomic nervous systems, gastrointestinal system, cardiovascular system, endocrine system, and pulmonary system; and special topics.

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