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JPETAB 226 (2) 303-632 (1983)

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The Journal of

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A Publication of The American Society

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©1980 D144E80

The Journal of

PHARMACOLOGYAND EXPERIMENTAL THERAPEUTICS

�4 Publication of The American Society

for Pharmacology and Experimental Therapeutics

Founded by John J. Abel 1909EDITOR

Eva King Killam

ASSISTANT EDITOR

Mannfred A. Hollinger

EDITORS FOR SPECIFIC FIELDS

Analgesia and Drug AbuseJoseph Cochin

Autonomic PharmacologyJoseph J. McPhiIIipsRObert E. Stitzel

Behavioral PharmacologyJohn A. Harvey

Cardiovascular PharmacologyHenry R. Beach, Jr.Theodore M. BrodyDonald V. Pnola

Cell PharmacologyToshio NarahashiGeorge B. Weiss

ChemotherapyH. George Mandel

Developmental PharmacologyBernard L Mirkin

Drug Metabolism and DispositionEdward BresnickJordan L Holtzman

Endocrine PharmacologyPaula H. Stern

Gastrointestinal PharmacologyThomas F. Burks

ImmunopharmacologySydney Spector

NeuropharmacologyS. J. EnnaA. James HenceCharles 0. Rutledge

Pmstaglandins and LeukotrienesJohn C. McGiff

Pulmonary PharmacologyMannfred A. HolIInger

Renal PharmacologyWilliam 0. Bemdt

ToxicologyCurtis D. Klaassen

EDITORIAL ADVISORY BOARD

Martin W. AdlerEdson X. AlbuquerqueEdmund G. AndersonLewis AronowLeslie E. BaileyMichael D. BailieRobert L. BalsterPaul BassJohn A. BevanC. Paul BianchiLeslie C. BlaberDavid A. BlakeFloyd E. BloomGary BrookerCarl K. BucknerDavid B. BylundTheodore J. CiceroDoris H. ClouetLeonard cookCharles A. CraigE. E. DanielWilliam C. de GroatLouis DiamondWalter A. DixonJames S. DouglasJ. W. DownieSue Piper DucklesLinda Dykstra

Hugh L. EvansJames A. FerrendelliGregory D. FinkLawrence J. FischerWilliam W. FlemingRay W. FullerTimothy S. GaginellaGerard L. GabberJames W. GibbShn N. GinDora B. GoldsteinFrank A. GoodmanCharles W. GorodetzkyTheodore E. GramGarrett J. GrossT. Kendall HardenHarold F. HardmanLouis S. HarrisRichard J. HeadPhilip C. HoffmannStephen G. HoftzmanJerry B. HookDavki M. JacobowftzDonald A. JasinskiAlain F. JunodS. M. KirpekarConan KometskyEdwin A. Kroeger

Wayne LevinLouis LevyRoberto LeviGeorge E. UndenmayerStephen L. UpsiusWafter LovenbergBenedict R. LucchesiK. U. MalikThomas A. McCaldenDonald E. McMillanJerry MttchellPerry B. MolinoffW. H. MorseKevin MullaneJose M. MusacchioMary J. MycekRobert A. NealPhilip NeedlemanAchilles J. PappanoWilliam A. PettingerLarissa A. PohoreckyRussell A. ProughJames W. Putney, Jr.Arthur RainesG. Alan RobisonC. R. RossCarl E. RosowRonald P. RubEn

Robert R. Ruffolo,Jr.Betty I. SasyniukArnold SchwartzLewis S. SeidenErICJ. SimonRoger P. SmithJohn L. SutkoBoris TabakoffRobert I. TaberA. E. TakemoriRobert E. Ten EickThomas A. TephlyRichard E. TesselC. D. ThronU. TrendelenburgBetty M. TwarogNorman J. UretskyLadislav VOIECerMartin A. WassermanI. M. WeinerBenjamin WeissRichard M. WelchDavid P. WestfallGrant R. WilkinsonMartin M. WinburyBarry B. WolfeBen G. Zimmerman

BOARD OF PUBLICATIONS TRUSTEES

Norman Weiner, Chairman: James A. Bain, Joel G. Hardman, Eva King Killam, Bathe Sue MastersJerry R. Mitchell, Walter Model, Paul L. Munson, Clement A. Stone, Palmer W. Taylor, Vincent G. Zannoni

EXECUTiVE OFFICER OF ThE SOCIETY

Kay Croker

THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (ISSN 0022-3565) is published monthly by The American Societyfor Pharmacology and Experimental Therapeutics, 428 E. Preston Street, Baltimore, MD 21202. Annual dues includes $60.00 for journal subscription.Second class postagepaid at Baltimore, MD and at additional mailing offices. POSTMASTER Send address changes (Form 3579) to Williams & Wilkins,428 E. Preston St., Baltimore, MD 21202. Indexed by Current Contents and Index Medicus. Subscription rates $140.00 ($165.00 foreign); institutions

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AUTHOR INDEX

Aass, H., 572Abiko, Y., 595Akera, T., 335Ali, B., 589

Ali, F. M., 608

Allen, T. M., 539Arbilla, S., 558Armbrecht, H. J., 387Banning, J. W., 469Barnett, A., 462Bianchi, B. R., 432

Blas,C., 526Branch, R. A, 486

Breese, G. R., 382Brocco, M. J., 449Brookins, J., 493Brown, J. H., 343Brown, N. L., 512Buckalew, V. M., Jr., 419

Burks, T. F., 356Camp, V. M., 608

Caplan, D. B., 608Chee, 0., 373

Chevillard, C., 512Costa, L. G., 392Cragoe, E., Jr., 368Daniell, H. B., 324de Jonge, A., 565Dietz, T. H., 455

Dykstra, L. A., 317Ellington, K., 382Everest, J. M., 539

Faraj, B. A., 608Ferron, A., 526Feuer, C., 603Fisher, J. W., 493

Foltin, R. W., 405, 411Fregly, M. J., 362

Fugman, D. A., 330Fujiwara, M., 507Gaffney, T. E., 324

Gale, K., 425Galligan, J. J., 356

Gaizin, A. M., 558Gardocki, J. F., 625Gerkens, J. F., 486

Gillis, R. A, 349Glowinski, J., 526Gualtieri, C. T., 382

Hamada, A., 469Hamosh, P., 349Hayashi, E., 519Hayashi, H., 507Herman, A. G., 579Houser, V. P., 462Hutchins, K., 362

Hwang, D. H., 455Hylden, J. L. K., 398Iorio, L. C., 462Isogai, M., 519

Jackson, E. K., 486Johnson, J. D., 330Johnston, M. G., 603Jordaens, F. H., 579Kaur, S., 589Keil, L. C., 373Kennedy, R. H., 335Kharasch, E. D., 500

Kikta, D. C., 362Kilts, C., 382Kim, D.-H., 335

Kits, S.-!., 595Korduba, C. A., 462Koster, A. S., 533

Kow, L.-M., 477Kraemer, G., 382

Lalley, P. M., 616Langer, S. Z., 558Leitz, F. H., 462Malveaux, E. J., 608McMillan, D. E., 440, 449

Melis, M. R., 425Miller, D. D., 469

Moerschbaecher, J. M., 349

Morris, M., 419Mueller, R. A., 382Muramatsu, I., 507

Murphy, S. D., 392Nelson, P. K., 493

Nishimura, T.-I., 595Noordhoek, J., 533Novak, R. F., 500Nowak, J. Z., 558Oates, J. A., 486

O’Donnell, M. E., 368Okudaira, H., 519Osnes, J.-B., 572Patil, P. N., 469

Patrick, K., 382Perkins, M. N., 551

Pfaff, D. W., 477Privitera, P. J., 324Raitano, L. A., 440Rastogi, S. K., 449Richard, J. W., 545Rosella-Dampman, L. M., 373Ruffolo, R. R., Jr., 469

Russell, M. P., 324Saintsing, D. G., 455

Sansehagrin, D., 545Schuster, C. R., 405, 411Shiverick, K. T., 362

Skomedal, T., 572

Soubrie, P., 526Squires, N., 362Stag, B. D., 419Stephens, J. K., 432Stittsworth, J. D., Jr., 432Stone, T. W., 551

Strandhoy, J. W., 419Strong, R., 387

Summy-Long, J. Y., 373Takimoto, G. S., 432Thakur, M., 545Thomas, B. N., 387Timmermans, P. B. M. W. M.,

565

Uderman, H. D., 486Ueda, N., 507van Zwieten, P. A., 565Verbeuren, T. J., 579

Villereal, M. L., 368Walle, T., 324Walsh, J. B., 387Wargin, W., 382

Webb, J. G., 324Wetzel, G. T., 343

Wilcox, G. L., 398Wise, R. W., 387Wong, S., 625Wood, P. L., 545Wood, W. G., 387Woolverton, W. L., 411.Worcel, M., 512

Workman, R. J., 486Yaksh, T. L., 303

Yamada, K. A., 349Yamada, S., 519Zemlin, F. P., 477Zimmerman, J. B., 486

-rhi8 One

I�DII�I�I�III�IIUI�I��IIIU��1I�II�IIIIII�IJEWL- 1 DF- PB3W

A21659ENaunyn-

Schmiedeberg’�

PI#June II

V. A. W. Kreye, J. C. RUegg, F. Hofmann:Effect of Calcium-Antagonist and Calmodulin-Antagonist Drugs on Calmodulin- DependentContractions of Chemically Skinned VascularSmooth Muscle from Rabbit Renal Arteries 85

V. Dole�al, S. Tu#{243}ek:The Effects of 4-Amino-pyridine and Tetrodotoxin on the Release ofAcetylcholine from Rat Striatal Slices 90

F. L#{252}bbecke, D. R. Ferry, H. Glossmann,E.-L. Sattler, G. Doell: Radiation Inactivationof Alpha1 -Adrenoceptors 96

E. Glusa, F. Markwardt: Characterisation ofPostjunctional a-Adrenoceptors in Isolated HumanFemoral Veins and Arteries 101

E. Schlicker, M. G#{246}thert, F. K#{246}stermann,R. Clausing : Effects of a-AdrenoceptorAntagonists on the Release of Serotonin andNoradrenaline from Rat Brain Cortex Slices.Influence of Noradrenaline Uptake Inhibition andDetermination of pA2Values 106

K. Uchida, Y. Kamikawa, J. Shimo: Time-Dependent Augmentation of the ContractileResponses to Adrenaline and Noradrenaline of theSuinea-Pig Esophageal Muscularis mucosae in/itro 114

�.1. Henseling: Accumulation of 3H-(-)Nor-adrenaline in the Rabbit Aorta not Related toUptake1 and Uptake2, but Sensitive to 3,4-Dihydroxy-2- Methylpropiophenone (U -0521 ) andOxytetracycline 121

II. Trendelenburg. F. J. E. Stefano,M. Grohmann : The Isotope Effect of Tritium in3H-Noradrenaline 128

Volume 323 Number 2 1983

I. C. Medgett: Effects of DPI (2-(3,4-Dihydroxyphenylimino) -Imidazolid me) onPrejunctional a-Adrenoceptors and PrejunctionalDopamine Receptors in the Rabbit Ear Artery141

R. Kullmann, W. R. Breull, K. Wassermann,A. Konopatzki : Blood Flow Redistribution byDopamine in the Feline Gastrointestinal Tract145

A. J. Kaumann : Yohimbine and RauwolscineInhibit 5- Hydroxytryptamine-lnduced Contractionof Large Coronary Arteries of Calf ThroughBlockade of 5 HT2 Receptors 149

B. Costall, R. J. Naylor, C. C. W. Tan : FieldStimulation-Induced Responses of CircularSmooth Muscle from Guinea-Pig Stomach.Characterisation of the Receptor MechanismsInvolved 155

A. Philippu, R. Hagen, U. Hanesch,U. Waldmann: Changes in the Arterial BloodPressure Increase the Release of EndogenousHistamine in the Hypothalamus of AnaesthetizedCats 162

G. W. Bourne, V. Th#{233}or#{234}t,B. Esplin,R., #{235}apek:Effect of Phencyclidine on Inhibitionin the Hippocampal Slice 168

E. Winter, P. Keen : Effects of SynthesisInhibition and Nervous Activity on Concentrationsof Neuronal Substance P 173

W. Christ, W. Hecker, H. Junge, G. Stille:Phase I Metabolism of Imipramine by Microsomesof Small Intestine in Comparison with Metabolismby Liver Microsomes 176

Indexed in Current Contents

e

Springer International21 0 Naunyn-Schmiedebergs Arch PharmacolISSN 0028-1298 NSAPCC 320(3) 206 274 (1982)

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O2�consumptionC02productionRespiration Rate

. One controller for I to 8 animal cages #{149}Continuous measurement of 02, CO2 andResptration Rate over a 24 hour period in mI/kg of body weight/hour in STP units.#{149}Pnnter pnnts results every four (4) minutes for each of 1 to 8 animals as well as oxygenpercent level in each animal cage #{149}System adaptable to small or large antmals #{149}Conttn.uous airflow through system with oxygen level measurements at the output and input#{149}High accuracy, >98% offull measurtng range e.g. typical error ±30 ml oxygen/kg/hour in3000 ml oxygen/kg/hour range #{149}User adjustable alarm warns user of possible hypoxia#{149}Reuseable absorbants #{149}Auto reference assures high accuracy, system periodicallymeasures ambient air and corrects itself #{149}Optional RS.232 interface for communicationwith other computers #{149}lnsensttive to temperature variations tn the antmal cage.

Columbus Instruments also supplies monior (or: Animal Actisity, C.rdi. Oulpue, Dunking and

Feeding, Respiration Rat. and Startle Response.

Frederick J. Di CarloSymposium Chairman

Ic�i� � �iing to Si�tmitManus�ts to

JOURNAL OF PHARMACOLOGY ANDEXPERIMENTAL THERAPEU’IWS

The expenses associated with the review of manuscripts submitted tothose ASPET-�sponsored journals that are devoted to publishing originalresearch articles have escalated dramatically in recent years because ofever-increasing costs of postage, supplies, and other office expenses, andthe growing number of manuscripts submitted for publication. In order tocontinue to offer authors the opportunity to publish their original researchin our critically reviewed, well-edited, and widely respected journ&s, ithas become necessary for ASPET to follow the example of several otherscientific societies which have instituted a uniform manuscript handlingfee for each of its journals that publishes original research reports.Therefore, all manuscripts received in the editorial office on or after July1, 1983, must be accompanied by a check of $30.00 (in U.S. funds payableto ASPET) or by a validated purchase order from the authors’ institution.The review process for submitted manuscripts will be delayed until themanuscript handling fee or purchase order is received in the appropriateEditor’s office. We regret the necessity of instituting a manuscripthandling fee. The Board of Publications Trustees has concluded, however,that this charge represents the fairest and most appropriate manner todefray the costs related to the review of submitted manuscripts.