The History of Lactateand its Modern

ImplicationsOdessa Addison, DPT

9/28/2009

History of Lactate 1808-Lacte identified by Berzelius

1891-Araki identified lactate concentrations rise in proportion to activation of exercised muscle. Thought this was related to oxygen availability.

History of Lactate 1907- Fletcher and Hopkins looked at

lactate in amphibian muscle Lactic acid appeared in response to muscle

contraction in absence of oxygen

Lactate disappeared when oxygen was present

History of Lactate 1920’s-Hill, Heidelberg, and Margaria

groups Identification of lactic acid cycle Aerobic and anaerobic pathways for cellular

energy supplies Rise of lactic acid at onset of exercise as result

of oxygen deficit Correlations of increased lactate and decreased

twitch force

Lactate Correlates to Decreased Twitch Force

Lactate

Force

History of Lactate “After these findings science sought to

prove lactate was the cause of fatigue rather then to question its function”

----Philp et al

After Lactate is produced how is it utilized?

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are needed to see this picture.

ICLS