Computa(onal Methods, based on humanbiology, are now reaching maturity in thebiomedical domain, rendering predic6vemodels of health and disease increasinglyrelevant to clinical prac6ce by providing apersonalized aspect to treatment. Computerbased modelling and simula6on is wellestablished in the physical sciences andengineering, where the use of highperformancecompu6ng(HPC)isnowrou6ne.CompBioMed is a user-driven Centre ofExcellence in Computa6onal Biomedicine, tonurture and promote the uptake andexploita6on of high performance compu6ngwithin the biomedical modelling community.Our user communi6es come from academia,industryandclinicalprac6ce.

The Healthcare Value Chain Entrepreneurial Opportuni(es: Our Centre of Excellence has innova6on at the forefront of its aims,promo6ng interdisciplinary entrepreneurial opportuni6es driven by our users’ needs. Our industrialpartnerspar6cipatefully intheCentre’sac6vi6esfromtheoutset,withthenumberofassociatepartnersexpectedtogrowcon6nuouslyoverthelife6meoftheCentre.Ac(vi(es:Wewill support and facilitatemodelling and simula6on ac6vi6es, and provide educa6on andtraining for adiverse setof communi6es.Wewill target research scien6sts fromphysical, computer andbiomedical sciences, soHware and infrastructure developers, from industry, and medical end users,includingclinicians. Wewill therefore invest incommunitybuilding tospreadknowledge, toolsandbestprac6cetostudentsandresearchersacrossthisdomain.So<ware: Our Centre of Excellence will provide a focal point for the development and sustainability ofsoHware tools and services which are capable of delivering high fidelity three and four dimensional(including6me)modellingandsimula6onofallaspectsofthehumanbody,fromthegenomicleveltothewholehumanandbeyond,inhealthanddisease.Transforming Industry: HPC has the poten6al to enhance industries in the healthcare sector includingpharmaceu6calsandmedicaldevicemanufacturers,andunderpinningarangeofemergingsectors,suchasthose concerned with e-health and personalised medicine. The innova6ve modelling and simula6ontechniqueswedevelopandpromotewithinthisCentrewillbeofgreatinterestandrelevancetoindustrialresearchers,HPCmanufacturersandindependentsoHwarevendors.

Research Cardiovascular medicine CardiovasculardiseaseaccountsforhalfofsuddendeathsinEurope; improvements in pa6ent risk stra6fica6on andpredic6on of clinical interven6on are both urgent andchallenging. In this area we study two cri6cally importantdiseaseareas:firstly,cardiovasculardiseaseshavingadirecteffect on the func6on of the heart itself, be it on theelectrophysiology,mechanicsorbloodflow(and,ul6mately,the combina6on of all three); and secondly, arterialdisorders ,be theyaneurysms in theabdominalaortaor inintracranial arteries, or stenosis in caro6d or coronaryarteries.Molecularly-based medicine Computa6onal models are becoming very powerful atdifferent stages in drug discovery and development frommolecule design to assessment of toxicity. Computa6onalmodels can also be used for reposi6oning and targe6ngtherapiesforprecisionmedicine,throughrapidandaccurateassessment of drug efficacy in specific disease cases. Theycan also provide added value to medical devicemeasurement data, for example as acquired by variousimagingmodali6es.Neuro-musculoskeletal medicineDespite a common percep6on that most neuro-musculoskeletal diseases are not life threatening, around30%of theelderswho faceanosteoporo6c fractureof thehipjointwilldieofrelatedcomplica6onswithin12months.We will inves6gate applica6ons such as skeletal muscle,car6lage,connec6ve6ssuemodellingofthedeforma6onof6ssuesunderbiomechanicalloads.

The Clinic Toandfromtheclinic:Wewillmanageandprovisionaccesstopersonal(pa6entspecific)derivedmedicaldata inaresearchenvironment.Wealsoneedtoperformhighfidelity3Dand4DHPCbasedsimula6onsand,atthesharpend,provideclinicaldecisionsupportwithinveryshort6meframes(oHenminutes,hoursorafewdays).Medical data: The rapid rise of detailed medical imaging, genomic data, abundant proteomic,metabolomic, biological, and physiological data on all levels of biological organisa6on (macromolecules,cells,6ssues,organs,organsystems,thewholebodyand,indeed,epidemiology),permitsthedevelopmentofmathema6callybased,mechanis6candpredic6vemul6scalemodelsofhumanhealthanddisease.ThesoHwaretoolsandtechniquesthatwedevelopwithinCompBioMedwillhelphealthcareproviderstomakesenseofthevastarrayofdatanowavailable,andwillhaveamajorimpactontheclinicaldecisionmakingprocess.

CompBioMedPrincipalInves6gator:ProfPeterCoveney Contact:h.mar6n@cbkscicon.comThisprojecthasreceivedfundingfromtheEuropeanUnion’sHorizon2020researchandinnova6on.