The Effect of Adding Oral Simvastatin to
Calcipotriol/Betamethasone Diproprionate Ointment for Treatment of
Psoriasis
The Effect of Adding Oral Simvastatin to
Calcipotriol/Betamethasone Diproprionate Ointmentfor Treatment of
PsoriasisNguye Trong Hao, 1 Tran hau Khang, 1 Nguyen Tat Thang 31
Hospital od Dermato-venereology, Ho Chi Minh City, vietnam2National
Hospital of Dermato-venereology, Vietnam3 Department of
Dermatology, University of Medicine and Pharmacy, Ho chi Minh City,
Vietnam. PsoriasisStatinsStatin: Mechanism of Action
StudyMethodsMethod (continued)Patient DistributionResultsTable
2
ResultsFigure 1DiscussionDiscussionLimited action of
lymphocyteImpaired infiltration into inflammation sitesMore
ReportsShirinsky et al., in Russia: 7 patients prescribed with
Simvastatin 40mg/d for 8 weeks, evaluated at week4 and 8, using
PASI and QLDI.Decreased PASIO score by 47,34% and downward in DLQI
score.2 patients : 50% PASI response2 patients : 75% PASI
responseStatins could have clinical utility in Psoriasis
treatment
Reduction in PASI score was more expressed in patients receiving
Simvastatin + topical 50% Betamethasone in petrolatum, no side
effect
Decreased risk of Psoriasis associated with Statin intake
(Wolkenstein et al. in France)
7 patients prescribed with Simvastatin 40mg/d for 8 weeks,
evaluated at week4 and 8, using PASI and QLDI.Decreased PASIO score
by 47,34% and downward in DLQI score.2 patients : 50% PASI
response2 patients : 75% PASI response
13Psoriasis First line therapySimvastatinStudy
LimitationConclusion
