The company of specialists.. 2Copyright © 2009 i3 | CONFIDENTIAL Economic Analyses of Niaspan ® in Latin America f or Abbott Laboratories Project Initiation

The company of specialists.

2Copyright © 2009 i3 | CONFIDENTIAL

Economic Analyses of Niaspan® in Latin Americafor Abbott Laboratories

Project Initiation Meeting

Rio de Janeiro, Brazil

9 September 2009


Agenda

Introductions Project Overview & Abbott Expectations i3 Innovus Review of Project Scope Role of Latin American Research Consortium Overview of Niaspan® Global Models Project Roles Project Deliverables & Timelines Final Questions


Introductions:Abbott

Abbott Global HEOR Bob Simko *Silky Webb

Abbott Latin America Diego Cortina; Abbott Mexico Gena Laranjeira; Abbott Brazil Paulo Vega Mateus; Abbott Colombia

* Abbott point-of-contact


Introductions:i3 Innovus Project Team

David Thompson; Project Director *Joanna Campbell; Senior Manager Hemangi Parekh; Research Analyst Kevin Leahy; Research Associate

* i3 Innovus point-of-contact


Introductions:i3 Innovus Latin American Research Partners

AxiaBio (Brazil) Gabriella Tannus de Araujo; Health Economics Director

Guia Mark (Mexico) Leon Zapata; Director General

HEORT (Colombia) Alejandro Bryon; Project Manager Ximena Burbano; Research Director

IECS (Argentina) Federico Augustovski; Director, Health Economic Evaluation


Project Overview & Abbott Expectations

Silky Webb; Abbott


i3 Innovus Review of Project Scope:Study Objectives

The specific objectives for this project are to:

Evaluate current Abbott global economic models of Niaspan® for suitability of adaptation to Latin America– Identify local-area data requirements

Identify, evaluate & collect local secondary data in six countries– Argentina, Brazil, Colombia, Mexico, Peru & Venezuela

Propose appropriate methods of supplementary primary data collection, where necessary


i3 Innovus Review of Project Scope:Develop Research Plan

i3 Innovus to work with Abbott to develop a written research plan for the project

Specify project objectives

Describe specific research tasks– Search strategy– Data evaluation guidelines– Data analysis plan for Brazil & Colombia– Criteria for assessing primary data collection strategies

Specify content & format of project deliverables – Data abstraction template– Study report outline


i3 Innovus Review of Project Scope:Evaluation of Niaspan® Global Economic Models

Conduct a thorough review of existing global Niaspan® models

Inventory the data requirements for each model

– Assess need for Latin American data inputs, target search for appropriate local-area data

Evaluate model flexibility in incorporating new treatment comparators – Treatments for hypercholesterolemia/mixed dyslipidemia– Treatments for disease-related complications

Document identified deficiencies and collaborate with Abbott to develop recommendations


i3 Innovus Review of Project Scope:Identification, Evaluation & Collection of Local-Area Data

Work with consortium of research partners in the Latin American region to

Identify sources for required local-area estimates:– disease epidemiology (prevalence & incidence)– clinical endpoints in model (e.g. plasma cholesterol, HDL-C, LDL-C,

triglycerides)– treatment patterns – costs of treatments for disease & disease-related complications

Evaluate quality of data sources

Abstract readily acquired data into excel spreadsheets– Where available, collect separate data for public & private payers


i3 Innovus Review of Project Scope:Identification, Evaluation & Collection of Local Data (cont’d)

Data searches will be conducted using English-, Portuguese-, and Spanish-language sources:– General: PubMed and Google Scholar

– Region-specific: LILACS, SciELO, Compumedicina

– PAHO publications

Review of publications by national statistical agencies– Epidemiology

– Healthcare resource use

– Healthcare costs


i3 Innovus Review of Project Scope:Identification, Evaluation & Collection of Local Data (cont’d)

Gaps likely in local secondary data sources

– Especially healthcare utilization (& costs)

High-quality electronic data resources in Brazil and Colombia already identified

– Data analysis plans to be reviewed by Abbott prior to implementation

Document remaining gaps in secondary sources– Evaluate alternative methods of supplementary primary data

collection for likely validity, cost, ease of acquisition• Advisory boards • Analysis of local hospital or payer databases • Chart reviews • Surveys of local providers and/or prayer representatives


i3 Innovus Review of Project Scope:Prepare Study Report

i3 Innovus will prepare a study report describing in detail the study’s objectives, methods, findings, and implications

Study report to center on:– Model evaluations– Results of search for local data– Recommendations for supplemental primary data collection


i3 Innovus Latin American Research PartnersGabriella Tannus de Araujo; AxiaBio

Ximena Burbano; HEORT

Federico Augustovski; IECS

Leon Zapata; Guia Mark


Overview of Niaspan® Global Models

Silky Webb; Abbott


Project Roles & Responsibilities:

Abbott Project Lead– Silky Webb;

Tel: 847.938.0200

email: [email protected]

i3 Innovus Project Manager

– Joanna Campbell;

Tel: 781.518.4017


Abbott – i3 Innovus Business Development Liaison– Kevin Kelly

Tel: 317.564.2913



Project Deliverables

Agenda & meeting summary for initial kick-off meeting Research plan: draft & final Study report w/ data appendices: draft & final


Project Timelines

*Dates & times of update calls to be confirmed

Task

ISPOR Latin America Meeting

1. Develop Research Plan

2. Evaluate Current Niaspan Global Economic Models

3. Identify, Evaluate & Collect Local Data on Disease Epidemiology & Clinical Endpoints in Six Latin American CountriesClinical Endpoints in Six Latin American Countries

4. Identify, Evaluate & Collect Local Data on Treatment Patterns & Local Pharmacoeconomic Data in Six Latin American CountriesPharmacoeconomic Data in Six Latin American Countries

5. Prepare Study Report & Presentation

Project Management

Bi-weekly update conference calls*

9 10 11 125 6 7 85-Oct

1 2 3 414-Sep 21-Sep 21-Sep 28-Sep 16-Nov

Project Gantt Chart:

Economic Analyses of Niaspan® in Latin America

12-Oct 19-Oct 2-Nov 9-Nov

Project Weeks

26-Oct7-Sep


Additional Questions


The company of specialists.

Documents

The company of specialists.. 2Copyright © 2009 i3 | CONFIDENTIAL Economic Analyses of Niaspan ® in Latin America f or Abbott Laboratories Project Initiation