Joseph B. Martin Conference Center

Harvard Medical School

This event is being photographed. The Child Health Committee and Symposium working group gratefully acknowledge the work of Linda Bard and Elyse Antrim on administrative aspects of the symposium.

Associate Professor of PediatricsHarvard Medical School Vice Chair, Department of Pediatric Newborn MedicineBrigham and Women’s Hospital

Virginia and D.K. Ludwig Professor of MedicineDean for Clinical and Translational ResearchHarvard Medical School Senior Vice President for Experimental MedicineDana-Farber Cancer Institute

Professor and Director of the Obesity Prevention Program, Department of Population Medicine Harvard Medical School Harvard Pilgrim Health Care Institute

George Putnam Professor of Organismic and Evolutionary Biology Harvard University

Professor of Obstetrics and Gynecology Director, Center for Pregnancy and Newborn Research University of Texas Health Science Center at San Antonio

Mark and Catherine Winkler Associate Professor of Environmental Epidemiology Harvard T.H. Chan School of Public Health

Assistant Professor of Pediatrics Harvard Medical School Department of Pediatric Newborn Medicine Brigham and Women’s Hospital

Investigator and Adult EndocrinologistJoslin Diabetes CenterAssistant Professor of MedicineHarvard Medical School

Associate Professor & Director of Faculty Development, Department of Population Medicine Harvard Medical School & Harvard Pilgrim Health Care InstituteAssociate Master, Oliver Wendell Holmes Society Harvard Medical School Associate Professor, Department of Nutrition Harvard T.H. Chan School of Public Health

Chief, Division of Pediatric Gastroenterology and NutritionDirector, Center for Celiac Research and TreatmentDirector, Mucosal Immunology and Biology Research CenterVice Chair, Department of Pediatrics, Basic, Clinical and Translational ResearchMassGeneral Hospital for ChildrenVisiting Professor of PediatricsHarvard Medical School

Division Chief, Pediatric EndocrinologyMassachusetts General HospitalProfessor of PediatricsHarvard Medical School

Chair, Department of Pediatric Newborn Medicine Brigham and Women’s Hospital Mary Ellen Avery Professor of PediatricsHarvard Medical School

Professor of Pediatrics and NeuroscienceHarvard Medical SchoolRichard David Scott Chair in Pediatric Developmental Medicine Research Boston Children’s Hospital

Senior Fellow, Economic Studies Director, Center on Social Dynamics & Policy The Brookings Institution Associate Professor (adjunct) Harvard T. H. Chan School of Public Health

Professor of International Pediatric Epidemiology MRC Lifecourse Epidemiology Unit University of Southampton, United Kingdom

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Associate Administrator, Maternal and Child Health, Health Resources and Services Administration US Department of Health and Human Services

Julius B. Richmond FAMRI Professor of Child Health and Development Harvard T.H. Chan School of Public Health Harvard Graduate School of Education Professor of Pediatrics Harvard Medical School Boston Children’s Hospital Director, Center on the Developing Child Harvard University

Mark and Catherine Winkler Associate Professor of Environmental Epidemiology Harvard T.H. Chan School of Public Health

Andrea Baccarelli, MD, PhD, MPH, is the Mark and Catherine Winkler Associate Professor of

Environmental Epidemiology in the Department of Environmental Health at the Harvard T.H. Chan School of Public Health. Baccarelli’s research focuses on epigenomics as a uni ue molecular substrate re ecting the impact of environmental exposures on human health. Baccarelli’s Laboratory of Human Environmental Epigenomics is dedicated to the investigation of environmental epigenetics at di erent life stages. His ongoing pro ects range from the investigation of the e ects of in-utero exposures to toxic metals, second-hand smoking, and psychosocial stress on the methylome of human fetal tissues, to the study of the in uences of air pollution on non-coding miRNA in adult and elderly individuals. Epigenetic mechanisms are investigated in relation to fetal growth and perinatal outcomes, cardiovascular function, obesity, and neuro-cognition. Since 2010, Baccarelli’s laboratory has produced more than 130 peer-reviewed publications in epigenetics, environmental health, and epidemiology. Baccarelli earned his MD from the University of Perugia, his PhD from the University of Milan, and his MPH from the University of Turin. He completed his residency (endocrinology) at the University of Milan, and a postdoctoral fellowship at the National Cancer Institute’s Division of Cancer Epidemiology and Genetics.

Professor of International Pediatric Epidemiology MRC Lifecourse Epidemiology Unit University of Southampton, United Kingdom

Caroline Fall, MBChB, DM, FRCP, FRCPCH, uali ed in medicine at Bristol University, UK, in 1979, followed by clinical training in medicine and pediatrics. She joined the MRC Lifecourse Epidemiology Unit, University of Southampton, to do her MD with Professor David Barker, who discovered the link between low birthweight and coronary heart disease which marked the beginning of research into Developmental Origins of Health and Disease (DOHaD). Fall then changed her career to full-time research, initially studying the Hertfordshire Cohort where she demonstrated that lower birthweight predicts an increased risk of adult type 2 diabetes. Since 1993, she has coordinated a DOHaD research program in India, working with groups in six centers on birth cohort studies and nutrition trials in pregnancy. Fall belongs to the COHORTS collaboration (birth cohorts in LMICs). With Indian colleagues, she organi ed the rst DOHaD World Congress in Mumbai (2001) and served as secretary of the International DOHaD Society (2003-2012).

Chief, Division of Pediatric Gastroenterology and NutritionDirector, Center for Celiac Research and TreatmentDirector, Mucosal Immunology and Biology Research CenterVice Chair, Department of Pediatrics, Basic, Clinical and Translational ResearchMassGeneral Hospital for ChildrenVisiting Professor of Pediatrics Harvard Medical School

Alessio Fasano, MD, is a pediatric gastroenterologist, research scientist, and entreprenuer who founded the Center for Celiac Research in 1996. His visionary research led to the awareness of celiac disease as a growing public health problem in the US. Fasano’s prevalence study published in 2003 established the rate of celiac disease at 1 in 133 Americans. In 2000, he and his team discovered zonulin, opening up the door to a new way of looking at the function of intestinal permeability, not only as it a ects the gut, but also what role it plays in both in ammation and autoimmunity throughout the systems of the body. As visiting professor at Harvard Medical School and chief of the Division of Pediatric Gastroenterology and Nutrition at Massachusetts General Hospital, Fasano moved the center to Boston in 2013, where he treats both children and adults for gluten-related disorders. A passionate advocate for collaboration in research and clinical work, Fasano recently authored Gluten Freedom to provide patients, healthcare providers and general readers an evidence-based yet entertaining book to dispel confusion about gluten and how it can a ect your health.

George Putnam Professor of Organismic and Evolutionary Biology Harvard University

David Haig, PhD, obtained his undergraduate and graduate degrees from Macquarie University in Sydney,

Australia. He had fellowships at Oxford and Harvard before joining the Harvard faculty in 1995. He has particular interests in the evolution of parent-o spring relations, genomic imprinting, and plant life cycles.

Professor and Director of the Obesity Prevention Program, Department of Population Medicine Harvard Medical School Harvard Pilgrim Health Care Institute

Matthew Gillman, MD, SM, is professor and director of the Obesity Prevention Program in the Department of Population Medicine at Harvard Medical School and Harvard Pilgrim Health Care Institute, and professor of nutrition at the Harvard T.H. Chan School of Public Health. Formerly a primary care internist and pediatrician, Gillman’s current clinical work is in preventive cardiology in children. Gillman’s research interests include early-life prevention of childhood and adult diseases, particularly obesity, diabetes, asthma, and cardiovascular disease; individual and policy-level interventions to prevent obesity and its consequences; and childhood cardiovascular risk factors. He directs Project Viva, a 15-year cohort study of pregnant women and their o spring, focusing on e ects of pre- and peri-natal factors on outcomes of pregnancy and childhood. He leads or participates in several other cohort studies as well as interventions to prevent obesity and chronic disease in the US and abroad. He has received numerous awards for his research. Gillman has served in leadership roles in the International Society for Developmental Origins of Health and Disease, the American Heart Association, and the American Academy of Pediatrics, and is a member of the US Preventive Services Task Force.

Senior Fellow, Economic Studies Director, Center on Social Dynamics & Policy The Brookings Institution Associate Professor (adjunct)

Harvard T. H. Chan School of Public Health

Ross A. Hammond, PhD, is senior fellow in economics at Brookings, where he is also director of the Center on Social Dynamics and Policy. His primary area of expertise is modeling dynamics in economic, social, and public health systems using methods from complexity science. His current research topics include obesity etiology and prevention, food systems, tobacco control, health disparities, literacy, crime, corruption, and decision-making. Hammond received his BA from Williams College and his PhD from the University of Michigan. He has authored numerous scienti c articles in prominent journals such as Lancet, AJPH, PNAS, and Evolution, and his work has been featured in major news media. Hammond was recently appointed to the advisory council for the National Institute of Minority Health & Health Disparities. He has also served on several committees at the Institute of Medicine, and has formal advisory positions at the National Cancer Institute and the FDA Center for Tobacco Products. He is on the editorial boards of several journals, and has been a member of four NIH-funded research networks using systems science (covering communicable disease, obesity, health disparities, and tobacco control). He currently holds appointments at Harvard T.H. Chan School of Public Health, the Santa Fe Institute, and University of Michigan.

Chair, Department of Pediatric Newborn Medicine Brigham and Women’s Hospital Mary Ellen Avery Professor of Pediatrics Harvard Medical School

Terrie Inder, MD, MBChB, is a dual-boarded newborn medicine physician and child neurologist, whose research focuses on the newborn brain. She manages clinical service within the neonatal intensive care unit, and since all her research activities are clinical investigations, her studies and clinical care of high-risk infants are tightly integrated. Inder’s research is targeted at understanding the timing, mechanisms, and impact of cerebral injury and altered cerebral development in the human infant. Thus, her studies have focused on infants at high risk for brain injury including those born premature, sick, and with congenital heart disease. Inder’s aim is to investigate the means of accurate and early diagnosis of brain injury, as well as to develop treatments and prevention strategies to reduce subsequent disabilities. Her research has utilized technologies such as near infrared spectroscopy, electroencephalography, and magnetic resonance imaging. In 2013, Inder was appointed chair of the new Department of Pediatric Newborn Medicine at Brigham and Women’s Hospital.

Associate Administrator, Maternal and Child Health Health Resources and Services Administration US Department of Health and Human Services

Michael Lu, MD, MS, MPH, was named associate administrator of maternal and child health of the Health

Resources and Services Administration (HRSA) on November 3, 2011. HRSA is an agency of the US Department of Health and Human Services. The mission of the Maternal and Child Health Bureau (MCHB) is to provide leadership, in partnership with key stakeholders, to improve the physical and mental health, safety and well-being of mothers, children and families. Through its Title V program, MCHB serves 40 million women, infants, children, adolescents, and their families each year, including fathers and children with special health care needs. Lu joined HRSA from the University of California, Los Angeles Schools of Medicine and Public Health, where he was associate professor of obstetrics, gynecology, and public health.

Lu brings years of experience in MCH research, practice, and policy to his post at HRSA. Prior to his appointment, Lu chaired the Secretary’s Advisory Committee on Infant Mortality. He has served on two Institute of Medicine (IOM) committees (Committee on Understanding Premature Birth and Assuring Healthy Outcomes, and Committee to Reexamine IOM Pregnancy Weight Guidelines), and the Centers for Disease Control and Prevention Select Panel on Preconception Care.

Professor of Obstetrics and Gynecology Director, Center for Pregnancy and Newborn Research University of Texas Health Science Center at San Antonio

Leslie Myatt, PhD, FRCOG, is professor of obstetrics and gynecology, and director of the Center for

Pregnancy and Newborn Research at the University of Texas Health Science Center at San Antonio. Myatt received both his BSc and PhD from the University of London, UK, and has served as North American editor of the journal Placenta (1997 to 2004), president of the Perinatal Research Society (1997), president of the International Federation of Placenta Associations (2002 to 2004), and president of the Society for Gynecologic Investigation (2009 to 2010). Myatt’s research interests are control of fetal placental vascular reactivity, the role of obesity, oxidative and nitrative stress in placental function and fetal programming, and the regulation of prostaglandin synthesis and action in intrauterine tissues at parturition. His current work focuses on the role of the maternal adiposity on epigenetic regulation of placental function and on placental mitochonial energetics. He has published over 240 papers and 350 abstracts and has served on many review panels and study sections for NIH, CIHR, and other international organizations. He was elected as a fellow (ad eundem) of the Royal College of Obstetricians and Gynaecologists in 2013 for his contributions to women’s health research.

Professor of Pediatrics and Neuroscience Harvard Medical School Richard David Scott Chair in Pediatric Developmental Medicine Research Boston Children’s Hospital

Charles A. Nelson III, PhD, is professor of pediatrics and neuroscience, and professor of psychology in the Department of Psychiatry at Harvard Medical School. Elsewhere at Harvard he holds faculty appointments at the Harvard T.H. Chan School of Public Health and the Harvard Graduate School of Education, and sits on the steering committee for the Harvard Center on the Developing Child and the Harvard interfaculty initiative on Mind, Brain, and Behavior. In addition, he holds the Richard David Scott Chair in Pediatric Developmental Medicine Research at Boston Children’s Hospital, and is director of research in the Division of Developmental Medicine. His research interests center on a variety of problems in developmental cognitive neuroscience, including developmental trajectories to autism and the e ects of early adversity (including psychosocial deprivation) on brain and behavioral development. He chaired the John D. and Catherine T. MacArthur Foundation Research Network on Early Experience and Brain Development, and served on the National Academy of Sciences (NAS) panels that wrote From Neurons to Neighborhoods, and more recently, New Directions in Child Abuse and Neglect Research. Among his many honors he has received the Leon Eisenberg award from Harvard Medical School, an honorary Doctorate from Bucharest University (Romania), was a resident fellow at the Rockefeller Foundation Bellagio Center (Italy), and has been elected to the American Academy of Arts and Sciences.

Associate Professor & Director of Faculty Development Department of Population Medicine Harvard Medical School & Harvard Pilgrim Health Care InstituteAssociate Master, Oliver Wendell Holmes Society Harvard Medical School Associate Professor, Department of Nutrition Harvard T.H. Chan School of Public Health

Emily Oken, MD, MPH, is an associate professor in the Department of Population Medicine at HMS and the Harvard Pilgrim Health Care Institute, and an associate professor in the Department of Nutrition at the Harvard T.H. Chan School of Public Health. Oken received her medical degree from HMS in 1996 and completed her internship and residency in internal medicine and pediatrics at the Harvard Combined Program. She completed her fellowship in general internal medicine at HMS, and obtained her master’s degree in public health from HSPH.

Oken’s research focuses on the in uence of nutrition and other modi able factors during pregnancy and early childhood on long-term maternal and child health, especially cardiometabolic health and cognitive development. She has also led a number of studies examining predictors and sequelae of maternal overweight, weight gain, and related conditions such as gestational diabetes mellitus in the peripartum period. Her work on the toxicant risks and nutrient bene ts of prenatal sh consumption has in uenced national guidelines for sh consumption during pregnancy, helping to shift the previous focus of risk-only or bene t-only studies to a broader emphasis on the overall health e ects of sh consumption for mother and baby. She has also published widely on perinatal in uences on child health including asthma and atopy. Oken’s commitment to mentorship has been recognized with a mid-career development grant from NICHD and an HMS Young Mentor Award.

Investigator and Adult Endocrinologist Joslin Diabetes Center Assistant Professor of Medicine Harvard Medical School

Mary-Elizabeth Patti, MD, FACP, received her medical degree from Je erson Medical College, followed by internal medicine residency at the University of Pittsburgh, and training in the joint Harvard Medical School endocrinology fellowship program. She is currently investigator, co-director of the Advanced Genetics and Genomics Core, and director of the Joslin Hypoglycemia Clinic, and assistant professor of medicine, Harvard Medical School. She was elected to the American Society of Clinical Investigation in 2009 and to fellowship in the American College of Physicians in 2014. Patti’s laboratory focuses on identi cation of molecular mechanisms by which environmental or nutritional risk factors (e.g. obesity, prenatal and early postnatal nutrition) in uence gene expression and metabolic function in tissues critical for insulin sensitivity and glucose tolerance. Ongoing studies are focused on understanding how the STARS-SRF pathway, a novel mediator of muscle insulin resistance and regulator of systemic metabolism identi ed in the Patti Lab, may serve as a target for treatment of type 2 diabetes. In addition, her laboratory is investigating how insulin resistance and nutrition during early life can a ect the metabolic function of stem cells.

Julius B. Richmond FAMRI Professor of Child Health and Development Harvard T.H. Chan School of Public Health Harvard Graduate School of Education Professor of Pediatrics Harvard Medical School Boston Children’s Hospital Director, Center on the Developing Child Harvard University

Jack Shonko , MD, is the Julius B. Richmond FAMRI Professor of Child Health and Development at the Harvard T.H. Chan School of Public Health and the Harvard Graduate School of Education; professor of pediatrics at Harvard Medical School and Boston Children’s Hospital; and director of the university-wide Center on the Developing Child at Harvard University. Under the auspices of the National Academy of Sciences, he served as Chair of the Board on Children, Youth, and Families, and chaired a blue-ribbon committee that produced the landmark report, From Neurons to Neighborhoods: The Science of Early Childhood Development. Shonko has received multiple honors, including elected membership to the Institute of Medicine of the National Academy of Sciences, the C. Anderson Aldrich Award in Child Development from the American Academy of Pediatrics, and the Award for Distinguished Contributions to Public Policy for Children from the Society for Research in Child Development. In 2011, he launched Frontiers of Innovation, a multi-dimensional learning community of researchers, practitioners, policymakers, investors, experts in systems change, and creative change agents who are committed to driving science-based innovation that achieves breakthrough impacts on the development and health of young children facing adversity.

About Harvard Catalyst

Founded in 2008, Harvard Catalyst | The Harvard Clinical and Translational Science Center is dedicated to improving human health by enabling collaboration and providing tools, training, and technologies to clinical and translational investigators. As a shared enterprise of Harvard University, Harvard Catalyst resources are available to all Harvard faculty and trainees, regardless of institutional a liation or academic degree.

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About Child Health at Harvard Catalyst

The Child Health Committee at Harvard Catalyst provides leadership and direction in the development of programs, resources, and strategies that focus on improving the health and wellbeing of children. The goal of this initiative is to foster collaboration across Harvard, its a liated institutions, and the national Clinical Translational Science Award (CTSA) Consortium, and to support innovative and collaborative research in this area. Committee co-chairs are Elizabeth Goodman, MD, and Ellis Neufeld, MD, PhD.

For more information, contact childhealth@catalyst.harvard.edu

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