Spike timing-dependent plasticity

Guoqiang Bi Department of Neurobiology University of Pittsburgh School of Medicine

When an axon of cell A is near enough to excite a cell B and repeatedly or persistently takes part in firing it, some growth process or metabolic change takes place in one or both cells such that As efficiency, as one of the cells firing B, is increased.

Donald O. Hebb, 1949

Cells that fire together, wire togetherQuestion:

How precise do the cells need to fire together in order to wire together?

Spike-timing-dependent synaptic plasticity

How does the timing of pre- and postsynaptic activity affect synaptic modification?

STDP in neuronal networks

How may a network change its configuration according to the temporal structure of in input stimuli?

Temporal integration of STDP

How is a synapse modified by natural spike trains?

+ bicuculline+ CNQX & bicucullineA. Glu - Glu+ CNQX+ bicuculline & CNQXB. Glu - GABAS1 S2R2R1*S1 S2R2R1Synaptic connectivity between cultured neurons

Paired pre- and postsynaptic spiking a true Hebbian paradigm

ABCLTP induced by paired spiking with positive timing

ABCLTD induced by paired spiking with negative timing

Markram et al. 1997

A critical window for synaptic modificationinduced by correlated spikingBi & Poo 1998

Froemke & Dan 2002

Zhang et al. 1998

Feldman 2000

Nishiyama et al. 2000

Bell et al. 1997

Spike-timing-dependent synaptic plasticity

Paired pre- and postsynaptic spiking induces LTP and LTD, depending on the precise spike timingSTDP is sensitive to neuronal cell typeSTDP requires NMDA receptors

STDP in neuronal networksHow may a network change its configuration according to the temporal structure of in input stimuli?

Temporal integration of STDPHow is a synapse modified by natural spike trains?Spike-timing-dependent synaptic plasticity

Paired pre- and postsynaptic spiking induces LTP and LTD, depending on the precise spike timingSTDP is sensitive to neuronal cell typeSTDP requires NMDA receptors

STDP in neuronal networksHow may a network change its configuration according to the temporal structure of in input stimuli?

Temporal integration of STDPHow is a synapse modified by natural spike trains?

Correlated spiking at remote synapses through convergent polysynaptic pathways a delay-line mechanism

Polysynaptic pathways in small neural networks

Long-term pathway remodeling inducedby repetitive paired-pulse stimulation

IPI(ms): 1005020321SSensitivity of pathway remodeling to inter-pulse interval (IPI) of input stimuli

IPI(ms): 150656555321S4Dependence of pathway remodeling on inter-pulse interval (IPI) of input stimuli

Pathway remodeling induced bypaired-pulse stimuli of different IPIs

IPI1 IPI2IPI1 IPI2

LTP and LTD at remote synapses induced by local paired pulse stimulationA1A2B1B2

Spike-timing-dependent synaptic plasticity

Paired pre- and postsynaptic spiking induces LTP and LTD, depending on the precise spike timingSTDP is sensitive to neuronal cell typeSTDP requires NMDA receptors

Remote STDP in neuronal networks

STDP occurs at synaptic sites remote to network input nodesSpike timing within the network can be coordinated by delay-lines formed by polysynaptic pathways.

Temporal integration of STDPSpike-timing-dependent synaptic plasticity

Paired pre- and postsynaptic spiking induces LTP and LTD, depending on the precise spike timingSTDP is sensitive to neuronal cell typeSTDP requires NMDA receptors

Remote STDP in neuronal networks

STDP occurs at synaptic sites remote to network input nodesSpike timing within the network can be coordinated by delay-lines formed by polysynaptic pathways.

Temporal integration of STDP

Temporal integration of STDP theoretical considerationsPan-spike interactionNear-neighbor interaction

Temporal integration of STDP Triplet interactions

Bi & Poo 1998

Temporally asymmetric interaction between LTP- and LTD-inducing processes

Froemke & Dan 2002

Spike-timing-dependent synaptic plasticity

Paired pre- and postsynaptic spiking induces LTP and LTD, depending on the precise spike timingSTDP is sensitive to neuronal cell typeSTDP requires NMDA receptors

Remote STDP in neuronal networks

STDP occurs at synaptic sites remote to network input nodesSpike timing within the network can be coordinated by delay-lines formed by polysynaptic pathways.

Temporal integration of STDP

In hippocampal cultures, LTP- and LTD-inducing processes integrate asymmetricallyDifferent systems with the same spike-timing window may have different integration rules.

AcknowledgementsUC San Diego Mu-ming Poo (Berkeley) Benedikt Berninger (Munich)

University of Pittsburgh Pakming Lau Huaixing Wang Joyeeta Dutta David Nauen

Needs update