Take a Close Look at Betaxolol This appears effective in the treatment of ocular hypertension In a 6-week study, 9 patients with elevated intraocular pressures (mean 31.8mm Hg) or chronic open-angle glaucoma were given betaxolol 0.25% (1 drop in each eye bid). Ten similar patients (mean intraocular pressure 29.9mm Hg) were given placebo during the double-blind trial. In the betaxolol-treated patients, mean intraocular pressure dropped by 10.1-14.5% relative to baseline and a near maximal decrease was seen after 1 week and was maintained throughout the 6 weeks of treatment. Improvements in intraocular pressure were significant compared with placebo. No significant changes from baseline, or intergroup differences, were seen in either heart rates or mean arterial pressures. Transient ocular discomfort occurred in 2 betaxolol recipients. The authors concluded that betaxolol has ' ... a significant hypotensive effect in the hypertensive human eye'. Feghafl JG. Kaufman PL American Journal of Ophthalmology 100 777182. Oec 1985 0156-2703/86/1005-0013/0$01.00/0 © ADIS Press INPHARMA® 22 Mar 1986 13

Take a Close Look at Betaxolol

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Take a Close Look at Betaxolol This ~-blocker appears effective in the treatment of ocular hypertension

In a 6-week study, 9 patients with elevated intraocular pressures (mean 31.8mm Hg) or chronic open-angle glaucoma were given betaxolol 0.25% (1 drop in each eye bid). Ten similar patients (mean intraocular pressure 29.9mm Hg) were given placebo during the double-blind trial.

In the betaxolol-treated patients, mean intraocular pressure dropped by 10.1-14.5% relative to baseline and a near maximal decrease was seen after 1 week and was maintained throughout the 6 weeks of treatment. Improvements in intraocular pressure were significant compared with placebo.

No significant changes from baseline, or intergroup differences, were seen in either heart rates or mean arterial pressures. Transient ocular discomfort occurred in 2 betaxolol recipients.

The authors concluded that betaxolol has ' ... a significant hypotensive effect in the hypertensive human eye'. Feghafl JG. Kaufman PL American Journal of Ophthalmology 100 777182. Oec 1985

0156-2703/86/1005-0013/0$01.00/0 © ADIS Press INPHARMA® 22 Mar 1986 13