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Table S1. Complete list of markers and quantile classifications included in analyses.
Abbreviation Common Name % Detectable Q1 Q2 Q3 Q4
MILLIPLEX MARKERS
CCL11/EOTAXIN CC motif ligand chemokine 11 100.0 ≤321.25 321.33-411.54 411.68-509.28 ≥509.51
CCL13/MCP4 CC motif ligand chemokine 13 55.9 <39.06 [LLOD] 39.58-58.68 58.71-84.26 ≥84.42
CCL15/MIP1D CC motif ligand chemokine 15 100.0 ≤2446.43 2450.04-3384.02 3384.87-5308.52 ≥5313.51
CCL17/TARC CC motif ligand chemokine 17 100.0 ≤13.79 13.8-19.14 19.15-27.75 ≥27.8
CCL19/MIP3B CC motif ligand chemokine 19 100.0 ≤119.84 119.86-158.87 158.93-217.54 ≥217.58
CCL2/MCP1 CC motif ligand chemokine 2 100.0 ≤445.38 445.4-549.69 549.89-674.99 ≥675.25
CCL20/MIP3A CC motif ligand chemokine 20 94.0 ≤5.15 5.16-7.92 7.95-12.22 ≥12.24
CCL21/6CKINE CC motif ligand chemokine 21 57.9 <78.13 [LLOD] 80.99-162.81 163.58-263.51 ≥264.02
CCL22/MDC CC motif ligand chemokine 22 100.0 ≤485.6 485.63-589.94 590.02-727.26 ≥727.52
CCL24/EOTAXIN2 CC motif ligand chemokine 24 99.8 ≤113.36 113.41-176.33 176.47-264.49 ≥264.92
CCL27/CTACK CC motif ligand chemokine 27 100.0 ≤589.96 590.34-726.74 727.28-888.33 ≥888.69
CCL3/MIP1A CC motif ligand chemokine 3 88.6 ≤28.96 28.99-43.08 43.14-75.13 ≥75.15
CCL4/MIP1B CC motif ligand chemokine 4 97.1 ≤38.66 38.75-59.72 59.81-102.3 ≥102.46
CCL8/MCP2 CC motif ligand chemokine 8 81.2 ≤8.98 8.99-16.79 16.84-23.33 ≥23.34
CRP C Reactive Protein 100.0 ≤2222800 2226700-4893900 4899900-10321000 ≥10355000
CX3CL1/
FRACTALKINE CX3C motif ligand chemokine 1 75.6 ≤44.63 48.97-227.76 228.76-401.59 ≥401.75
CXCL1/GRO CXC motif ligand chemokine 1 100.0 ≤707.21 708.28-955.63 956.08-1278.79 ≥1281.83
CXCL10/IP-10 CXC motif lignad chemokine 10 100.0 ≤430.13 430.25-568.57 568.78-749.24 ≥749.91
CXCL11/I-TAC CXC motif ligand chemokine 11 100.0 ≤166.27 166.42-225.33 226.23-302.8 ≥303.03
CXCL12/SDF1 CXC motif ligand chemokine 12 99.9 ≤1087.61 1088.95-1387.2 1387.39-1755.8 ≥1756.25
CXCL13/BCA1 CXC motif ligand chemokine 13 100.0 ≤17.02 17.06-22.89 22.96-30.66 ≥30.73
CXCL5/ENA78 CXC motif ligand chemokine 5 100.0 ≤296.4 296.49-441.52 442.23-745.01 ≥745.78
CXCL6/GCP2 CXC motif ligand chemokine 6 100.0 ≤45.7 45.74-61.6 61.69-80.66 ≥80.75
CXCL8/IL8 Interleukin 8 99.7 ≤10.57 10.59-22.06 22.07-78.81 ≥78.82
CXCL9/MIG CXC motif ligand chemokine 9 100.0 ≤758.7 758.75-1046.2 1046.94-1547.62 ≥1549.64
EGF Epidermal growth factor 90.1 ≤28.39 28.44-49.06 49.08-97.56 ≥97.68
FGF2/BFGF Fibroblast growth factor 2 65.0 <16 [LLOD] 16.37-119.84 120.9-219.35 ≥220.42
GCSF
Granulocyte-colony stimulating
factor 78.9 ≤21.42 21.46-44.01 44.02-71.71 ≥71.74
GM-CSF
Granulocyte-macrophage colony-
stimulating factor 87.1 ≤24.07 24.13-53.11 53.14-88.87 ≥88.94
IL10 Interleukin 10 56.8 <1.48 [LLOD] 1.48-7.89 7.93-14.87 ≥14.88
IL12/P70 Interleukin 12 p70 87.3 ≤3.54 3.55-7.49 7.52-11.65 ≥11.66
IL13 Interleukin 13 69.2 <0.96 [LLOD] 0.98-6.65 6.66-12.89 ≥12.91
IL16 Interleukin 16 93.5 ≤34.11 34.15-49.82 49.86-71.23 ≥71.36
IL17A Interleukin 17 alpha 88.0 ≤4.58 4.61-9.01 9.06-16.47 ≥16.48
IL1B Interleukin 1 beta 73.3 <0.48 [LLOD] 0.48-2.1 2.11-3.5 ≥3.51
IL1RA Interleukin 1 receptor alpha 66.3 <16 [LLOD] 16.1-55.05 55.27-116.93 ≥117.11
IL21 Interleukin 21 58.7 <0.96 [LLOD] 0.96-2.08 2.09-4.64 ≥4.65
IL23 Interleukin 23 81.6 ≤86.56 86.74-215.14 215.44-438.34 ≥439.94
IL29/IFNL1 Interleukin 29 21.0 <48.83 [LLOD] ≥66.62
IL33 Interleukin 33 22.5 <4.88 [LLOD] >=4.9
IL4 Interleukin 4 19.9 <7.32 [LLOD] ≥7.4
IL5 Interleukin 5 85.6 ≤1.64 1.65-3.67 3.68-6.03 ≥6.04
IL6 Interleukin 6 87.5 ≤1.17 1.18-2.35 2.36-3.85 ≥3.86
IL7 Interleukin 7 74.0 <1.48 [LLOD] 1.48-6.96 7-11.11 ≥11.12
SAA Serum amyloid A 96.2 ≤1657200 1657600-3113400 3114300-6467600 ≥6471400
SAP Serum amyloid P 100.0 ≤44444000 44502000-56756000 56762000-71779000 ≥71809000
pg/mL
SCF Stem cell factor 90.5 ≤16.6 16.63-26.05 26.08-37.55 ≥37.63
sEGFR
Soluble epidermal growth factor
receptor 99.9 ≤92894.67 92927.02-104158.65
sGP130 Soluble glycoprotein 130 99.9 ≤243357.3 243403.38-281952.39 281979.26-320430.17 ≥320665.79
sIL4R Soluble interleukin 4 receptor 98.1 ≤504.13 505.36-616.34 616.67-800.69 ≥801.06
sIL6R Soluble interleukin 6 receptor 99.9 ≤24936.58 24949.38-32436.14 32444.12-40459.99 ≥40466.21
sILR2
Soluble interleukin 1 receptor,
type II 99.9 ≤6535.87 6547.17-8201.33 8204.02-10498.9 ≥10508.22
sTNFR1
Soluble tumor necrosis factor
receptor, type I 99.9 ≤1544.36 1544.77-1850.02 1850.77-2203.51 ≥2206.45
sTNFR2
Soluble tumor necrosis factor
receptor, type II 99.9 ≤6418.29 6428.68-7754.05 7756.04-9379.25 ≥9380.91
sVEGFR2
Soluble vascular endothelial
growth factor receptor 2 99.9 ≤14204.35 14229.21-16719.06 16720.56-20370 ≥20418.65
sVEGFR3
Soluble vascular endothelial
growth factor receptor 3 97.9 ≤2385.38 2398.13-3563.49 3565.45-5000.05 ≥5022.33
TGFA Transforming growth factor alpha 81.7 ≤1.01 1.02-2.29 2.3-4.32 ≥4.33
TNFA Tumor necrosis factor alpha 100.0 ≤12.07 12.08-16.53 16.54-24.97 ≥24.99
TPO Thrombopoietin 100.0 ≤190.44 190.47-245.39 245.62-328.19 ≥328.33
TRAIL
Tumor necrosis factor related
apoptosis inducing ligand 99.5 ≤43.55 43.58-56.49 56.59-71.98 ≥72
TSLP Thymic stromal lymphopoietin 15.1 <2.44 [LLOD] ≥2.44
VEGF
Vascular endothelial growth
factor 63.1 <16 [LLOD] 21.02-167.93 168.9-295.97 ≥296.41
PROSEEK MARKERS
ADA Adenosine deaminase 100.0 ≤ 3.53 3.53 - < 3.73 3.73 - < 3.92 ≥ 3.92
AXIN1 Axin 1 46.9 ≤ 2.02 2.02 - < 3.99
BNGF Beta nerve growth factor 99.2 ≤ 1.39 1.41 - < 1.58 1.59 - < 1.79 ≥ 1.79
CASP8 Caspase 8 99.0 ≤ 3.91 3.91 - < 4.27 4.27 - < 4.82 ≥ 4.82
CCL23/MIP3 CC motif ligand chemokine 23 100.0 ≤ 8.84 8.84 - < 9.13 9.13 - < 9.40 ≥ 9.41
CCL25/TECK CC motif ligand chemokine 25 71.6 ≤ 5.32 5.32 - < 5.69 5.69 - < 6.07 ≥ 6.08
CCL28/MEC CC motif ligand chemokine 28 71.6 ≤ 1.36 1.36 - < 1.56
CD244 Natural killer cell receptor 2B4 100.0 ≤ 5.64 5.64 - < 5.81 5.81 - < 6.04 ≥ 6.04
CD40 CD 40L Receptor 100.0 ≤ 9.36 9.36 - < 9.56 9.56 - < 9.80 ≥ 9.80
CD5 T-cell surface glycoprotein CD5 100.0 ≤ 4.75 4.75 - < 4.95 4.95 - < 5.18 ≥ 5.18
CD6 T-cell surface glycoprotein CD6 100.0 ≤ 4.38 4.38 - < 4.65 4.65 - < 4.92 ≥ 4.92
CDCP1 CUB domain containing protein 1 100.0 ≤ 3.64 3.65 - < 4.05 4.07 - < 4.57 ≥ 4.57
CSF1 Colony stimulating factor 1 100.0 ≤ 7.58 7.58 - < 7.70 7.70 - < 7.84 ≥ 7.84
CST5 Cystatin-D 100.0 ≤ 6.06 6.06 - < 6.36 6.36 - < 6.75 ≥ 6.76
DNER
Delta/Notch like EGF repeat
containing protein 100.0≤ 8.31 8.31 - < 8.48 8.48 - < 8.65
≥ 8.65
ENRAGE
Extracellular newly identified
receptor for advanced glycation
end-products 99.0
≤ 2.59 2.61 - < 3.12 3.12 - < 3.69
≥ 3.71
FGF19 Fibroblast growth factor 19 100.0 ≤ 7.76 7.77 - < 8.48 8.48 - < 9.17 ≥ 9.17
FGF21 Fibroblast growth factor 21 100.0 ≤ 4.43 4.44 - < 5.25 5.25 - < 6.02 ≥ 6.02
FGF23 Fibroblast growth factor 23 99.9 ≤ 2.07 2.07 - < 2.29 2.30 - < 2.53 ≥ 2.53
FLT3L
Fms related tyrosine kinase 3
ligand 100.0≤ 8.51 8.52 - < 8.79 8.79 - < 9.06
≥ 9.06
HGF Hepatocyte growth factor 100.0 ≤ 7.70 7.70 - < 7.94 7.94 - < 8.24 ≥ 8.24
IL10RA Interleukin 10 receptor alpha 35.0 ≤ 1.12 1.12 - < 6.62
IL10RB Interleukin 10 receptor beta 100.0 ≤ 6.75 6.75 - < 6.95 6.95 - < 7.15 ≥ 7.16
IL12B Interleukin 12 beta 100.0 ≤ 3.20 3.20 - < 3.60 3.61 - < 3.93 ≥ 3.93
IL17C Interleukin 17C 14.7 ≤ 4.10 ≥ 4.10
IL18R1 Interleukin 18 receptor 1 100.0 ≤ 6.65 6.65 - < 6.88 6.88 - < 7.09 ≥ 7.10
IL18 Interleukin 18 100.0 ≤ 6.89 6.89 - < 7.19 7.19 - < 7.55 ≥ 7.55
TGFB1/LAB
Transforming growth factor beta
1 100.0 ≤ 6.91 6.91 - < 7.12 7.12 - < 7.38 ≥ 7.39
NPX values
LIFR
Leukemia inhibitory factor
receptor 100.0≤ 2.83 2.83 - < 3.00 3.00 - < 3.18
≥ 3.18
CCL7/MCP3
CC motif ligand chemokine
7/MCP3 95.9≤ 2.47 2.48 - < 2.76 2.76 - < 3.16
≥ 3.16
MMP1 Matrix metalloproteinase 1 100.0 ≤ 11.53 11.54 - < 12.13 12.13 - < 12.78 ≥ 12.79
MMP10 Matrix metalloproteinase 10 100.0 ≤ 6.08 6.08 - < 6.44 6.44 - < 6.89 ≥ 6.90
NT3 Neurotrophin 3 38.2 ≤ 1.47 1.47 - < 3.57
OPG Osteoprotegrin 100.0 ≤ 10.18 10.18 - < 10.41 10.41 - < 10.59 ≥ 10.60
OSM Oncostatin M 92.3 ≤ 2.08 2.10 - < 3.20 3.21 - < 4.18 ≥ 4.20
PDL1 Programmed cell death ligand 1 100.0 ≤ 3.45 3.46 - < 3.67 3.67 - < 3.87 ≥ 3.90
SIRT2 SIR2-like protein 2 37.0 ≤ 1.93 1.93 - < 6.79
SLAMF1
Signaling lymphocytic activation
molecule 78.3≤ 1.44 1.44 - < 1.70 1.70 - < 1.98
≥ 1.99
ST1A1 Sulfotransferase 1A1 74.0 ≤ 1.92 1.92 - < 2.82 2.83 - < 4.97
STAMPB STAM binding protein 100.0 ≤ 3.37 3.37 - < 3.70 3.71 - < 4.23 ≥ 4.24
TNFB Tumor necrosis factor beta 100.0 ≤ 3.30 3.30 - < 3.58 3.58 - < 3.87 ≥ 3.88
TNFRSF9
Tumor necrosis factor receptor
superfamily 9 100.0≤ 5.65 5.65 - < 5.90 5.90 - < 6.19
≥ 6.19
TNFSF14
Tumor necrosis factor
superfamily 14 100.0≤ 4.25 4.25 - < 4.83 4.84 - < 5.55
≥ 5.55
TRANCE
Tumor necrosis factor activation
induced cytokine 100.0≤ 3.22 3.22 - < 3.64 3.64 - < 4.06
≥ 4.07
TWEAK
Tumor necrosis factor ligand
superfamily member 12 100.0≤ 8.70 8.70 - < 8.89 8.90 - < 9.13
≥ 9.13
UPA
Urokinase-type plasminogen
activator 100.0≤ 10.08 10.08 - < 10.28 10.28 - < 10.49
≥ 10.49
VEGFA
Vascular endothelial growth
factor alpha 100.0≤ 8.65 8.66 - < 8.89 8.89 - < 9.15
≥ 9.15
4E-BP1
Eukaryotic translation initiation
factor 4E-binding protein 1 100.0≤ 4.24 4.24 - < 4.87 4.88 - < 5.61
≥ 5.61
Table S2. Associations between AHA/NHLBI metabolic syndrome and marker quantiles.
OR1 (95% CI) OR2 (95% CI) FDR P-Value
CCL21/6CKINE 1.09 (0.79 - 1.51) 1.10 (0.78 - 1.53) 0.783
CXCL13/BCA1 1.40 (1.01 - 1.93) 1.41 (1.02 - 1.96) 0.226
CCL19/MIP3B 2.11 (1.53 - 2.93) 2.06 (1.48 - 2.88) 0.001
CCL20/MIP3A 1.27 (0.91 - 1.78) 1.21 (0.86 - 1.71) 0.606
CRP 2.22 (1.60 - 3.08) 2.07 (1.48 - 2.90) 0.001
CCL27/CTACK 0.81 (0.58 - 1.11) 0.71 (0.51 - 0.99) 0.226
CXCL11/ITAC 1.35 (0.98 - 1.86) 1.27 (0.92 - 1.77) 0.495
CXCL6/GCP2 1.33 (0.96 - 1.85) 1.29 (0.92 - 1.81) 0.493
CXCL9/MIG 1.24 (0.89 - 1.72) 1.16 (0.83 - 1.62) 0.685
EGF 0.91 (0.65 - 1.26) 0.99 (0.71 - 1.39) 0.975
CXCL5/ENA78 1.02 (0.74 - 1.41) 1.06 (0.76 - 1.48) 0.879
CCL24/EOTAXIN2 1.21 (0.88 - 1.68) 1.27 (0.91 - 1.78) 0.499
CCL11/EOTAXIN 0.86 (0.61 - 1.19) 0.83 (0.59 - 1.17) 0.606
FGF2 0.90 (0.66 - 1.25) 0.88 (0.64 - 1.23) 0.764
CX3CL1/FRACTALKINE 0.97 (0.67 - 1.39) 0.95 (0.65 - 1.37) 0.898
GCSF 0.93 (0.68 - 1.28) 0.93 (0.67 - 1.29) 0.845
GMCSF 0.67 (0.47 - 0.95) 0.67 (0.47 - 0.95) 0.210
CXCL1/GRO 0.81 (0.59 - 1.12) 0.82 (0.59 - 1.14) 0.593
IL16 1.19 (0.85 - 1.66) 1.16 (0.83 - 1.63) 0.685
IL1RA 0.81 (0.59 - 1.13) 0.79 (0.57 - 1.11) 0.499
IL8 0.85 (0.60 - 1.19) 0.87 (0.61 - 1.23) 0.736
IL10 1.07 (0.74 - 1.54) 1.08 (0.75 - 1.56) 0.845
IL12p70 0.81 (0.57 - 1.17) 0.82 (0.57 - 1.18) 0.606
IL13 0.81 (0.56 - 1.15) 0.81 (0.56 - 1.16) 0.593
IL17A 0.86 (0.60 - 1.22) 0.87 (0.61 - 1.24) 0.736
IL1B 0.67 (0.47 - 0.97) 0.66 (0.45 - 0.96) 0.213
IL21 1.05 (0.72 - 1.53) 1.04 (0.71 - 1.53) 0.910
IL23 0.79 (0.55 - 1.12) 0.78 (0.54 - 1.12) 0.499
IL5 0.70 (0.49 - 1.01) 0.69 (0.48 - 1.00) 0.247
IL6 0.70 (0.48 - 1.03) 0.68 (0.46 - 1.01) 0.268
IL7 1.03 (0.71 - 1.49) 1.04 (0.71 - 1.51) 0.910
IP10 1.17 (0.84 - 1.62) 1.12 (0.80 - 1.56) 0.764
CCL2/MCP1 1.55 (1.12 - 2.16) 1.58 (1.13 - 2.21) 0.096
CCL8/MCP2 1.13 (0.82 - 1.54) 1.11 (0.80 - 1.53) 0.769
CCL13/MCP4 1.36 (0.98 - 1.89) 1.33 (0.95 - 1.86) 0.378
CCL22/MDC 1.01 (0.73 - 1.39) 0.96 (0.69 - 1.34) 0.909
CCL4/MIP1B 1.07 (0.77 - 1.48) 1.03 (0.74 - 1.44) 0.910
CCL15/MIP1D 1.13 (0.81 - 1.56) 1.10 (0.79 - 1.54) 0.778
CCL3/MIP1A 1.03 (0.72 - 1.49) 0.99 (0.68 - 1.45) 0.979
SAA 1.50 (1.09 - 2.06) 1.42 (1.03 - 1.96) 0.213
SAP 2.05 (1.46 - 2.88) 2.08 (1.47 - 2.95) 0.001
SCF 1.45 (1.04 - 2.01) 1.44 (1.03 - 2.02) 0.213
CXCL12/SDF1AB 0.48 (0.34 - 0.66) 0.45 (0.32 - 0.63) < 0.001
SEGFR 1.04 (0.73 - 1.47) 1.12 (0.79 - 1.60) 0.764
SGP130 1.35 (0.95 - 1.91) 1.34 (0.94 - 1.92) 0.421
SIL4R 1.01 (0.71 - 1.44) 0.99 (0.69 - 1.42) 0.975
SIL6R 1.28 (0.90 - 1.80) 1.22 (0.86 - 1.75) 0.606
SILRII 1.19 (0.83 - 1.69) 1.27 (0.88 - 1.83) 0.547
STNFRI 1.25 (0.89 - 1.76) 1.24 (0.87 - 1.76) 0.593
STNFRII 1.28 (0.90 - 1.83) 1.19 (0.83 - 1.71) 0.663
SVEGFR2 1.16 (0.82 - 1.65) 1.17 (0.82 - 1.69) 0.685
SVEGFR3 1.45 (1.01 - 2.07) 1.39 (0.96 - 1.99) 0.337
CCL17/TARC 0.71 (0.51 - 0.97) 0.66 (0.48 - 0.92) 0.152
TGFA 0.83 (0.60 - 1.16) 0.82 (0.58 - 1.15) 0.593
TNFA 1.50 (1.08 - 2.09) 1.49 (1.06 - 2.09) 0.204
TPO 0.96 (0.70 - 1.33) 0.93 (0.67 - 1.29) 0.845
TRAIL 1.61 (1.17 - 2.23) 1.59 (1.14 - 2.22) 0.079
VEGF 1.18 (0.85 - 1.62) 1.22 (0.88 - 1.69) 0.593
ADA 1.01 (0.64 - 1.59) 1.09 (0.68 - 1.74) 0.879
AXIN1 1.12 (0.65 - 1.95) 1.27 (0.72 - 2.25) 0.721
BNGF 1.13 (0.71 - 1.79) 1.17 (0.73 - 1.88) 0.764
4E-BP1 1.11 (0.69 - 1.79) 1.08 (0.66 - 1.76) 0.898
CASP8 1.11 (0.70 - 1.76) 1.13 (0.70 - 1.81) 0.809
CCL23/MIP3 0.66 (0.41 - 1.05) 0.63 (0.39 - 1.02) 0.268
CCL25/TECK 0.92 (0.58 - 1.44) 0.88 (0.55 - 1.40) 0.783
CCL28/MEC 0.44 (0.28 - 0.71) 0.44 (0.27 - 0.71) 0.016
CD244 0.87 (0.55 - 1.38) 0.85 (0.53 - 1.37) 0.764
CD40 1.14 (0.72 - 1.80) 1.15 (0.72 - 1.84) 0.769
CD5 1.86 (1.17 - 2.96) 1.73 (1.07 - 2.79) 0.210
CD6 1.71 (1.07 - 2.73) 1.59 (0.98 - 2.58) 0.272
CDCP1 1.38 (0.86 - 2.23) 1.46 (0.89 - 2.39) 0.493
CSF1 1.08 (0.69 - 1.71) 1.01 (0.63 - 1.62) 0.975
CST5 0.95 (0.61 - 1.48) 0.85 (0.54 - 1.36) 0.764
DNER 0.94 (0.59 - 1.51) 0.96 (0.59 - 1.55) 0.910
ENRAGE 1.10 (0.69 - 1.73) 1.04 (0.65 - 1.68) 0.910
FGF19 0.87 (0.55 - 1.38) 0.92 (0.58 - 1.48) 0.879
FGF21 1.27 (0.80 - 1.99) 1.27 (0.79 - 2.04) 0.631
FGF23 1.39 (0.88 - 2.21) 1.29 (0.80 - 2.07) 0.606
FLT3L 1.20 (0.75 - 1.93) 1.16 (0.71 - 1.90) 0.769
HGF 1.25 (0.78 - 1.99) 1.30 (0.81 - 2.11) 0.606
IL10RB 1.15 (0.72 - 1.83) 1.17 (0.72 - 1.88) 0.764
IL12B 1.57 (0.97 - 2.54) 1.34 (0.82 - 2.20) 0.593
IL18R1 2.36 (1.46 - 3.79) 2.37 (1.45 - 3.87) 0.012
IL18 1.65 (1.04 - 2.63) 1.67 (1.03 - 2.70) 0.226
TGFB1/LAB 1.34 (0.85 - 2.10) 1.29 (0.81 - 2.06) 0.606
LIFR 0.95 (0.59 - 1.53) 0.96 (0.59 - 1.56) 0.910
CCL7/MCP3 1.23 (0.77 - 1.98) 1.29 (0.80 - 2.10) 0.606
MMP1 0.84 (0.53 - 1.32) 0.81 (0.51 - 1.29) 0.685
MMP10 0.85 (0.53 - 1.36) 0.87 (0.54 - 1.42) 0.783
NT3 1.22 (0.74 - 2.02) 1.18 (0.71 - 1.98) 0.764
OPG 0.85 (0.54 - 1.34) 0.85 (0.53 - 1.36) 0.764
OSM 0.51 (0.31 - 0.84) 0.52 (0.31 - 0.88) 0.152
PDL1 1.11 (0.70 - 1.75) 1.05 (0.65 - 1.68) 0.910
SLAMF1 1.42 (0.89 - 2.25) 1.26 (0.78 - 2.02) 0.663
ST1A1 1.11 (0.69 - 1.79) 1.11 (0.68 - 1.81) 0.845
STAMPB 0.95 (0.60 - 1.50) 1.03 (0.64 - 1.65) 0.938
TNFB 1.66 (1.03 - 2.67) 1.47 (0.89 - 2.41) 0.492
TNFRSF9 1.60 (1.00 - 2.57) 1.41 (0.86 - 2.30) 0.499
TNFSF14 0.78 (0.49 - 1.23) 0.80 (0.49 - 1.28) 0.665
TRANCE 2.04 (1.26 - 3.29) 2.02 (1.24 - 3.29) 0.075
TWEAK 0.76 (0.48 - 1.21) 0.70 (0.44 - 1.13) 0.495
UPA 0.78 (0.50 - 1.23) 0.84 (0.53 - 1.34) 0.764
VEGFA 1.36 (0.86 - 2.15) 1.40 (0.88 - 2.25) 0.499
IL29/IFNL1 1.45 (0.95 - 2.20) 1.54 (1.00 - 2.37) 0.247
IL33 0.91 (0.58 - 1.42) 0.94 (0.59 - 1.49) 0.901
IL4 1.09 (0.66 - 1.81) 1.14 (0.68 - 1.90) 0.809
TSLP 0.95 (0.56 - 1.62) 0.93 (0.53 - 1.61) 0.901
IL10RA 0.86 (0.41 - 1.77) 0.76 (0.36 - 1.62) 0.764
IL17C 1.65 (0.79 - 3.44) 1.63 (0.74 - 3.57) 0.593
SIRT2 0.78 (0.36 - 1.69) 0.89 (0.40 - 2.00) 0.901
OR1 is adjusted for age, sex, and study site.
OR2 is further adjusted for smoking (never/past/current), alcohol use (never/<weekly, <150g/week, 150-<300g/week, 300+ g/week), fasting status at
blood draw(<8 hrs/ 8+ hrs), and low PA.
Adjusted P-Values presented for OR2 only, and bold face denotes FDR P-value < 0.05.
Table S3. Associations between low physical activity and marker quantiles.
OR1 (95% CI) OR2 (95% CI) FDR P-Value
CCL21/6CKINE 1.15 (0.83 - 1.59) 1.15 (0.83 - 1.61) 0.735
CXCL13/BCA1 1.20 (0.87 - 1.64) 1.20 (0.87 - 1.65) 0.632
CCL19/MIP3B 1.49 (1.09 - 2.04) 1.48 (1.08 - 2.05) 0.239
CCL20/MIP3A 1.03 (0.75 - 1.40) 1.04 (0.76 - 1.43) 0.965
CRP 1.35 (0.98 - 1.85) 1.33 (0.96 - 1.84) 0.523
CCL27/CTACK 1.38 (1.00 - 1.91) 1.46 (1.05 - 2.02) 0.267
CXCL11/ITAC 1.11 (0.81 - 1.51) 1.02 (0.74 - 1.41) 0.965
CXCL6/GCP2 1.16 (0.84 - 1.59) 1.07 (0.77 - 1.47) 0.919
CXCL9/MIG 1.27 (0.92 - 1.75) 1.19 (0.86 - 1.66) 0.662
EGF 0.84 (0.62 - 1.16) 0.84 (0.61 - 1.16) 0.662
CXCL5/ENA78 0.67 (0.48 - 0.92) 0.68 (0.49 - 0.95) 0.267
CCL24/EOTAXIN2 1.03 (0.75 - 1.41) 0.98 (0.71 - 1.36) 0.965
CCL11/EOTAXIN 0.87 (0.64 - 1.20) 0.87 (0.63 - 1.20) 0.735
FGF2 1.51 (1.09 - 2.09) 1.54 (1.11 - 2.14) 0.222
CX3CL1/FRACTALKINE 0.98 (0.70 - 1.38) 1.00 (0.71 - 1.41) 0.998
GCSF 0.96 (0.70 - 1.33) 0.97 (0.69 - 1.34) 0.965
GMCSF 1.15 (0.82 - 1.60) 1.17 (0.83 - 1.65) 0.735
CXCL1/GRO 0.86 (0.63 - 1.18) 0.87 (0.63 - 1.20) 0.735
IL16 0.93 (0.68 - 1.29) 0.95 (0.68 - 1.32) 0.951
IL1RA 1.17 (0.85 - 1.61) 1.18 (0.85 - 1.63) 0.714
IL8 0.83 (0.60 - 1.16) 0.82 (0.58 - 1.16) 0.631
IL10 1.28 (0.90 - 1.83) 1.29 (0.90 - 1.86) 0.612
IL12p70 0.98 (0.70 - 1.38) 1.03 (0.73 - 1.45) 0.965
IL13 1.00 (0.71 - 1.41) 1.02 (0.72 - 1.45) 0.965
IL17A 1.01 (0.72 - 1.42) 1.02 (0.73 - 1.44) 0.965
IL1B 1.16 (0.82 - 1.64) 1.19 (0.83 - 1.71) 0.720
IL21 0.99 (0.69 - 1.42) 1.00 (0.69 - 1.45) 0.998
IL23 1.01 (0.72 - 1.43) 1.05 (0.74 - 1.49) 0.965
IL5 0.86 (0.61 - 1.21) 0.87 (0.62 - 1.24) 0.763
IL6 1.19 (0.83 - 1.69) 1.27 (0.89 - 1.83) 0.612
IL7 0.89 (0.63 - 1.26) 0.93 (0.66 - 1.33) 0.919
IP10 1.13 (0.82 - 1.54) 1.13 (0.81 - 1.56) 0.790
CCL2/MCP1 1.45 (1.06 - 1.99) 1.36 (0.98 - 1.88) 0.445
CCL8/MCP2 1.00 (0.73 - 1.37) 0.97 (0.70 - 1.33) 0.965
CCL13/MCP4 1.06 (0.76 - 1.48) 1.04 (0.74 - 1.46) 0.965
CCL22/MDC 0.95 (0.69 - 1.31) 0.98 (0.71 - 1.36) 0.965
CCL4/MIP1B 1.06 (0.77 - 1.46) 0.99 (0.71 - 1.39) 0.998
CCL15/MIP1D 1.14 (0.83 - 1.56) 1.17 (0.84 - 1.61) 0.730
CCL3/MIP1A 1.03 (0.73 - 1.47) 0.99 (0.69 - 1.43) 0.998
SAA 1.27 (0.93 - 1.73) 1.31 (0.95 - 1.80) 0.527
SAP 1.37 (0.99 - 1.90) 1.34 (0.96 - 1.87) 0.523
SCF 1.45 (1.05 - 1.99) 1.49 (1.07 - 2.06) 0.239
CXCL12/SDF1AB 1.21 (0.88 - 1.66) 1.23 (0.89 - 1.70) 0.612
SEGFR 1.15 (0.82 - 1.62) 1.16 (0.82 - 1.65) 0.735
SGP130 1.56 (1.11 - 2.18) 1.57 (1.11 - 2.21) 0.222
SIL4R 1.08 (0.77 - 1.52) 1.09 (0.78 - 1.54) 0.891
SIL6R 1.76 (1.24 - 2.49) 1.77 (1.24 - 2.52) 0.092
SILRII 0.86 (0.61 - 1.22) 0.91 (0.64 - 1.29) 0.879
STNFRI 1.05 (0.75 - 1.48) 1.00 (0.71 - 1.41) 0.998
STNFRII 1.51 (1.07 - 2.14) 1.45 (1.01 - 2.06) 0.377
SVEGFR2 1.21 (0.86 - 1.69) 1.27 (0.90 - 1.80) 0.612
SVEGFR3 1.20 (0.85 - 1.69) 1.16 (0.82 - 1.64) 0.735
CCL17/TARC 0.81 (0.59 - 1.11) 0.82 (0.59 - 1.13) 0.612
TGFA 1.06 (0.77 - 1.47) 1.07 (0.77 - 1.49) 0.919
TNFA 1.15 (0.84 - 1.59) 1.07 (0.77 - 1.49) 0.919
TPO 1.36 (1.00 - 1.87) 1.39 (1.01 - 1.91) 0.377
TRAIL 1.16 (0.84 - 1.60) 1.16 (0.84 - 1.61) 0.735
VEGF 0.89 (0.65 - 1.22) 0.88 (0.63 - 1.22) 0.763
ADA 0.75 (0.49 - 1.16) 0.75 (0.48 - 1.17) 0.612
AXIN1 0.69 (0.41 - 1.16) 0.64 (0.37 - 1.09) 0.541
BNGF 1.02 (0.67 - 1.56) 0.96 (0.62 - 1.49) 0.965
4E-BP1 0.96 (0.60 - 1.53) 0.96 (0.60 - 1.54) 0.965
CASP8 1.06 (0.67 - 1.67) 1.06 (0.66 - 1.70) 0.965
CCL23/MIP3 1.16 (0.75 - 1.78) 1.22 (0.78 - 1.89) 0.735
CCL25/TECK 1.19 (0.77 - 1.84) 1.35 (0.86 - 2.11) 0.612
CCL28/MEC 0.89 (0.58 - 1.36) 0.98 (0.63 - 1.52) 0.965
CD244 1.30 (0.84 - 2.01) 1.35 (0.86 - 2.10) 0.612
CD40 1.10 (0.71 - 1.69) 1.09 (0.70 - 1.70) 0.919
CD5 1.79 (1.15 - 2.80) 1.92 (1.22 - 3.03) 0.180
CD6 1.33 (0.86 - 2.08) 1.35 (0.86 - 2.13) 0.612
CDCP1 1.14 (0.73 - 1.79) 1.09 (0.69 - 1.73) 0.919
CSF1 1.28 (0.83 - 1.98) 1.36 (0.87 - 2.11) 0.612
CST5 0.94 (0.61 - 1.46) 0.97 (0.63 - 1.51) 0.965
DNER 0.71 (0.46 - 1.09) 0.75 (0.48 - 1.16) 0.612
ENRAGE 1.32 (0.85 - 2.05) 1.41 (0.90 - 2.21) 0.584
FGF19 1.02 (0.66 - 1.58) 1.07 (0.68 - 1.68) 0.952
FGF21 1.06 (0.69 - 1.63) 1.17 (0.75 - 1.82) 0.803
FGF23 1.35 (0.87 - 2.07) 1.32 (0.85 - 2.06) 0.612
FLT3L 1.45 (0.93 - 2.25) 1.53 (0.97 - 2.42) 0.445
HGF 1.29 (0.82 - 2.01) 1.33 (0.84 - 2.10) 0.612
IL10RB 1.56 (1.00 - 2.43) 1.52 (0.97 - 2.39) 0.445
IL12B 2.16 (1.38 - 3.38) 2.22 (1.40 - 3.52) 0.081
IL18R1 1.28 (0.83 - 1.96) 1.28 (0.82 - 1.98) 0.648
IL18 1.35 (0.87 - 2.10) 1.36 (0.87 - 2.14) 0.612
TGFB1/LAB 1.25 (0.80 - 1.96) 1.20 (0.75 - 1.90) 0.763
LIFR 1.25 (0.81 - 1.93) 1.31 (0.84 - 2.04) 0.612
CCL7/MCP3 1.11 (0.71 - 1.73) 1.10 (0.69 - 1.73) 0.919
MMP1 0.78 (0.50 - 1.21) 0.85 (0.55 - 1.34) 0.803
MMP10 0.89 (0.58 - 1.37) 0.88 (0.56 - 1.37) 0.864
NT3 0.93 (0.57 - 1.52) 0.90 (0.54 - 1.48) 0.919
OPG 0.98 (0.63 - 1.54) 1.10 (0.69 - 1.74) 0.919
OSM 0.83 (0.52 - 1.30) 0.84 (0.53 - 1.33) 0.763
PDL1 1.39 (0.89 - 2.16) 1.41 (0.90 - 2.22) 0.584
SLAMF1 1.00 (0.65 - 1.52) 1.05 (0.68 - 1.62) 0.965
ST1A1 0.89 (0.57 - 1.39) 0.92 (0.58 - 1.45) 0.919
STAMPB 0.80 (0.52 - 1.24) 0.77 (0.49 - 1.19) 0.612
TNFB 1.76 (1.12 - 2.76) 1.75 (1.10 - 2.78) 0.239
TNFRSF9 1.42 (0.91 - 2.21) 1.45 (0.92 - 2.30) 0.558
TNFSF14 0.82 (0.53 - 1.28) 0.88 (0.56 - 1.38) 0.864
TRANCE 1.34 (0.87 - 2.08) 1.29 (0.83 - 2.01) 0.631
TWEAK 1.58 (1.02 - 2.45) 1.61 (1.02 - 2.52) 0.377
UPA 0.97 (0.63 - 1.50) 0.92 (0.59 - 1.44) 0.919
VEGFA 1.35 (0.88 - 2.06) 1.35 (0.87 - 2.10) 0.612
IL29/IFNL1 0.88 (0.57 - 1.37) 0.87 (0.56 - 1.37) 0.864
IL33 1.44 (0.94 - 2.20) 1.50 (0.97 - 2.32) 0.445
IL4 1.25 (0.75 - 2.08) 1.29 (0.76 - 2.17) 0.723
TSLP 0.83 (0.49 - 1.41) 0.85 (0.49 - 1.46) 0.864
IL10RA 1.18 (0.62 - 2.27) 1.20 (0.61 - 2.36) 0.879
IL17C 0.66 (0.30 - 1.41) 0.61 (0.27 - 1.36) 0.612
SIRT2 0.60 (0.30 - 1.20) 0.57 (0.28 - 1.18) 0.584
OR1 is adjusted for age, sex, and study site.
OR2 is further adjusted for smoking (never/past/current), alcohol use (never/<weekly, <150g/week, 150-<300g/week, 300+ g/week), fasting status at
blood draw(<8 hrs/ 8+ hrs), and MetS.
Adjusted P-Values presented for OR2 only, and bold face denotes FDR P-value < 0.05.
Table S4. Associations between obesity (BMI> 25 kg/m2) and marker quantiles.
OR1 (95% CI) OR2 (95% CI) FDR P-Value
CCL21/6CKINE 1.16 (0.87 - 1.56) 1.15 (0.86 - 1.55) 0.675
CXCL13/BCA1 1.45 (1.09 - 1.94) 1.47 (1.10 - 1.98) 0.101
CCL19/MIP3B 1.87 (1.40 - 2.50) 1.91 (1.42 - 2.57) 0.001
CCL20/MIP3A 0.97 (0.72 - 1.30) 0.95 (0.71 - 1.28) 0.917
CRP 2.11 (1.58 - 2.82) 2.16 (1.61 - 2.90) < 0.001
CCL27/CTACK 0.85 (0.64 - 1.13) 0.83 (0.62 - 1.12) 0.621
CXCL11/ITAC 1.34 (1.00 - 1.78) 1.36 (1.01 - 1.81) 0.230
CXCL6/GCP2 1.21 (0.90 - 1.63) 1.14 (0.84 - 1.54) 0.704
CXCL9/MIG 1.13 (0.84 - 1.52) 1.15 (0.85 - 1.55) 0.683
EGF 0.92 (0.69 - 1.22) 0.96 (0.71 - 1.28) 0.917
CXCL5/ENA78 0.94 (0.71 - 1.25) 0.96 (0.71 - 1.28) 0.917
CCL24/EOTAXIN2 1.09 (0.81 - 1.45) 1.12 (0.84 - 1.50) 0.750
CCL11/EOTAXIN 0.85 (0.63 - 1.14) 0.86 (0.64 - 1.16) 0.652
FGF2 0.93 (0.70 - 1.24) 0.95 (0.71 - 1.27) 0.917
CX3CL1/FRACTALKINE 1.11 (0.81 - 1.51) 1.01 (0.74 - 1.39) 0.982
GCSF 0.82 (0.62 - 1.09) 0.81 (0.61 - 1.08) 0.513
GMCSF 0.85 (0.62 - 1.15) 0.84 (0.62 - 1.15) 0.633
CXCL1/GRO 0.73 (0.55 - 0.97) 0.72 (0.54 - 0.97) 0.207
IL16 0.93 (0.70 - 1.25) 0.91 (0.68 - 1.23) 0.828
IL1RA 0.98 (0.74 - 1.30) 0.99 (0.74 - 1.32) 0.978
IL8 0.73 (0.54 - 0.99) 0.74 (0.54 - 1.01) 0.247
IL10 1.04 (0.76 - 1.42) 1.06 (0.77 - 1.47) 0.917
IL12p70 1.06 (0.78 - 1.46) 1.05 (0.76 - 1.45) 0.917
IL13 0.92 (0.67 - 1.26) 0.87 (0.63 - 1.20) 0.706
IL17A 1.10 (0.81 - 1.49) 1.08 (0.79 - 1.47) 0.917
IL1B 0.84 (0.61 - 1.15) 0.83 (0.60 - 1.14) 0.621
IL21 1.21 (0.87 - 1.68) 1.22 (0.87 - 1.70) 0.621
IL23 0.97 (0.71 - 1.32) 0.95 (0.69 - 1.30) 0.917
IL5 0.97 (0.71 - 1.32) 0.90 (0.66 - 1.24) 0.822
IL6 0.96 (0.70 - 1.32) 0.96 (0.69 - 1.32) 0.917
IL7 1.03 (0.75 - 1.42) 1.00 (0.72 - 1.39) 0.991
IP10 1.44 (1.08 - 1.92) 1.48 (1.10 - 1.99) 0.101
CCL2/MCP1 1.37 (1.02 - 1.84) 1.44 (1.07 - 1.94) 0.165
CCL8/MCP2 1.03 (0.77 - 1.37) 1.10 (0.82 - 1.47) 0.822
CCL13/MCP4 0.99 (0.74 - 1.33) 1.00 (0.74 - 1.35) 0.996
CCL22/MDC 0.96 (0.72 - 1.29) 1.02 (0.76 - 1.37) 0.973
CCL4/MIP1B 1.02 (0.76 - 1.37) 1.06 (0.79 - 1.43) 0.917
CCL15/MIP1D 1.06 (0.79 - 1.40) 1.03 (0.77 - 1.38) 0.930
CCL3/MIP1A 1.08 (0.78 - 1.49) 1.07 (0.77 - 1.49) 0.917
SAA 1.65 (1.23 - 2.20) 1.64 (1.22 - 2.20) 0.015
SAP 1.28 (0.95 - 1.73) 1.41 (1.04 - 1.91) 0.195
SCF 1.17 (0.88 - 1.56) 1.17 (0.87 - 1.57) 0.639
CXCL12/SDF1AB 0.70 (0.53 - 0.94) 0.73 (0.55 - 0.98) 0.217
SEGFR 0.89 (0.65 - 1.21) 0.95 (0.69 - 1.31) 0.917
SGP130 1.12 (0.82 - 1.53) 1.13 (0.82 - 1.56) 0.759
SIL4R 1.04 (0.76 - 1.42) 1.06 (0.77 - 1.46) 0.917
SIL6R 0.93 (0.68 - 1.27) 0.93 (0.68 - 1.28) 0.917
SILRII 1.29 (0.94 - 1.76) 1.39 (1.01 - 1.92) 0.230
STNFRI 1.28 (0.94 - 1.75) 1.33 (0.97 - 1.83) 0.315
STNFRII 1.09 (0.79 - 1.49) 1.07 (0.77 - 1.48) 0.917
SVEGFR2 1.14 (0.83 - 1.57) 1.20 (0.87 - 1.67) 0.621
SVEGFR3 1.08 (0.79 - 1.48) 1.05 (0.76 - 1.45) 0.917
CCL17/TARC 0.89 (0.66 - 1.19) 0.87 (0.64 - 1.17) 0.675
TGFA 0.87 (0.65 - 1.16) 0.88 (0.65 - 1.18) 0.704
TNFA 1.27 (0.95 - 1.71) 1.31 (0.97 - 1.77) 0.315
TPO 0.73 (0.55 - 0.98) 0.75 (0.56 - 1.01) 0.247
TRAIL 1.78 (1.33 - 2.38) 1.80 (1.34 - 2.42) 0.002
VEGF 1.02 (0.77 - 1.37) 1.02 (0.76 - 1.37) 0.973
ADA 1.54 (1.03 - 2.30) 1.50 (1.00 - 2.26) 0.244
AXIN1 0.99 (0.60 - 1.63) 0.97 (0.58 - 1.61) 0.973
BNGF 0.64 (0.42 - 0.96) 0.61 (0.41 - 0.93) 0.193
4E-BP1 1.31 (0.86 - 2.01) 1.34 (0.87 - 2.07) 0.568
CASP8 1.27 (0.85 - 1.92) 1.30 (0.86 - 1.98) 0.621
CCL23/MIP3 0.76 (0.50 - 1.16) 0.75 (0.49 - 1.14) 0.568
CCL25/TECK 0.97 (0.65 - 1.46) 1.02 (0.67 - 1.53) 0.978
CCL28/MEC 0.51 (0.34 - 0.77) 0.47 (0.31 - 0.72) 0.010
CD244 0.92 (0.61 - 1.39) 0.91 (0.60 - 1.38) 0.917
CD40 1.17 (0.79 - 1.75) 1.21 (0.80 - 1.81) 0.683
CD5 1.39 (0.92 - 2.10) 1.45 (0.96 - 2.20) 0.315
CD6 1.53 (1.00 - 2.33) 1.53 (1.00 - 2.35) 0.244
CDCP1 0.76 (0.50 - 1.17) 0.80 (0.52 - 1.23) 0.639
CSF1 1.30 (0.86 - 1.96) 1.25 (0.83 - 1.89) 0.639
CST5 0.84 (0.56 - 1.26) 0.79 (0.52 - 1.19) 0.621
DNER 1.07 (0.71 - 1.62) 1.07 (0.70 - 1.63) 0.917
ENRAGE 0.96 (0.64 - 1.43) 0.95 (0.63 - 1.43) 0.917
FGF19 0.71 (0.47 - 1.09) 0.71 (0.46 - 1.08) 0.399
FGF21 0.89 (0.60 - 1.33) 0.94 (0.63 - 1.42) 0.917
FGF23 1.23 (0.82 - 1.86) 1.09 (0.72 - 1.65) 0.917
FLT3L 2.00 (1.30 - 3.08) 2.05 (1.32 - 3.18) 0.019
HGF 1.31 (0.86 - 1.98) 1.40 (0.92 - 2.13) 0.419
IL10RB 1.07 (0.71 - 1.60) 1.13 (0.75 - 1.71) 0.845
IL12B 1.68 (1.09 - 2.57) 1.66 (1.07 - 2.56) 0.195
IL18R1 2.35 (1.56 - 3.56) 2.34 (1.54 - 3.54) 0.002
IL18 1.49 (0.99 - 2.26) 1.62 (1.06 - 2.46) 0.195
TGFB1/LAB 1.16 (0.77 - 1.74) 1.17 (0.77 - 1.77) 0.759
LIFR 1.11 (0.74 - 1.65) 1.19 (0.79 - 1.79) 0.709
CCL7/MCP3 1.96 (1.30 - 2.97) 2.10 (1.38 - 3.19) 0.010
MMP1 0.71 (0.47 - 1.06) 0.69 (0.46 - 1.05) 0.318
MMP10 0.64 (0.42 - 0.96) 0.65 (0.43 - 0.99) 0.230
NT3 1.32 (0.84 - 2.07) 1.27 (0.80 - 2.00) 0.639
OPG 0.77 (0.51 - 1.16) 0.77 (0.51 - 1.17) 0.621
OSM 0.77 (0.49 - 1.19) 0.78 (0.50 - 1.21) 0.631
PDL1 0.90 (0.60 - 1.36) 0.96 (0.63 - 1.45) 0.930
SLAMF1 1.04 (0.69 - 1.56) 0.98 (0.65 - 1.48) 0.978
ST1A1 1.07 (0.70 - 1.63) 1.05 (0.68 - 1.61) 0.930
STAMPB 1.02 (0.68 - 1.54) 1.04 (0.68 - 1.56) 0.966
TNFB 1.36 (0.88 - 2.10) 1.37 (0.89 - 2.13) 0.519
TNFRSF9 1.22 (0.81 - 1.85) 1.24 (0.82 - 1.89) 0.639
TNFSF14 0.75 (0.49 - 1.14) 0.76 (0.50 - 1.16) 0.621
TRANCE 1.23 (0.82 - 1.85) 1.27 (0.84 - 1.92) 0.621
TWEAK 0.86 (0.57 - 1.31) 0.87 (0.57 - 1.32) 0.808
UPA 0.81 (0.54 - 1.21) 0.81 (0.53 - 1.22) 0.642
VEGFA 0.97 (0.65 - 1.46) 1.02 (0.68 - 1.54) 0.973
IL29/IFNL1 1.11 (0.75 - 1.64) 1.15 (0.77 - 1.71) 0.808
IL33 0.97 (0.65 - 1.45) 1.00 (0.66 - 1.50) 0.991
IL4 1.31 (0.84 - 2.02) 1.32 (0.84 - 2.07) 0.621
TSLP 1.37 (0.87 - 2.16) 1.32 (0.83 - 2.10) 0.621
IL10RA 1.17 (0.62 - 2.20) 1.14 (0.59 - 2.18) 0.917
IL17C 0.47 (0.20 - 1.10) 0.39 (0.16 - 0.94) 0.219
SIRT2 0.66 (0.32 - 1.35) 0.72 (0.34 - 1.49) 0.684
OR1 is adjusted for age, sex, and study site.
OR2 is further adjusted for smoking (never/past/current), alcohol use (never/<weekly, <150g/week, 150-<300g/week, 300+ g/week), fasting status at
blood draw(<8 hrs/ 8+ hrs), and low PA.
Adjusted P-Values presented for OR2 only, and bold face denotes FDR P-value < 0.05.
Table S5. Associations between low HDL and marker quantiles.
OR1 (95% CI) OR2 (95% CI) FDR P-Value
CCL21/6CKINE 1.48 (1.09 - 2.00) 1.46 (1.07 - 1.99) 0.101
CXCL13/BCA1 1.56 (1.15 - 2.11) 1.59 (1.16 - 2.17) 0.031
CCL19/MIP3B 1.99 (1.48 - 2.70) 1.83 (1.34 - 2.49) 0.005
CCL20/MIP3A 1.61 (1.19 - 2.18) 1.60 (1.17 - 2.18) 0.029
CRP 2.28 (1.68 - 3.10) 2.14 (1.56 - 2.93) < 0.001
CCL27/CTACK 0.98 (0.73 - 1.33) 0.89 (0.65 - 1.21) 0.642
CXCL11/ITAC 1.40 (1.04 - 1.87) 1.40 (1.03 - 1.90) 0.152
CXCL6/GCP2 1.70 (1.25 - 2.30) 1.78 (1.30 - 2.43) 0.008
CXCL9/MIG 1.75 (1.29 - 2.39) 1.76 (1.28 - 2.41) 0.009
EGF 1.19 (0.88 - 1.62) 1.34 (0.98 - 1.83) 0.227
CXCL5/ENA78 1.26 (0.94 - 1.71) 1.31 (0.97 - 1.79) 0.238
CCL24/EOTAXIN2 0.92 (0.68 - 1.23) 0.91 (0.67 - 1.24) 0.718
CCL11/EOTAXIN 0.94 (0.69 - 1.27) 0.86 (0.63 - 1.18) 0.552
FGF2 1.00 (0.74 - 1.35) 0.96 (0.71 - 1.31) 0.851
CX3CL1/FRACTALKINE 1.29 (0.92 - 1.79) 1.28 (0.91 - 1.80) 0.377
GCSF 1.01 (0.75 - 1.36) 1.03 (0.76 - 1.40) 0.884
GMCSF 0.93 (0.67 - 1.29) 0.91 (0.65 - 1.27) 0.720
CXCL1/GRO 1.26 (0.94 - 1.70) 1.35 (0.99 - 1.83) 0.221
IL16 1.12 (0.83 - 1.53) 1.18 (0.86 - 1.61) 0.520
IL1RA 0.87 (0.64 - 1.17) 0.86 (0.63 - 1.18) 0.550
IL8 1.09 (0.79 - 1.49) 1.15 (0.83 - 1.59) 0.607
IL10 1.25 (0.89 - 1.76) 1.23 (0.87 - 1.74) 0.466
IL12p70 1.15 (0.83 - 1.59) 1.14 (0.82 - 1.60) 0.632
IL13 1.14 (0.82 - 1.58) 1.15 (0.82 - 1.61) 0.607
IL17A 1.19 (0.85 - 1.65) 1.13 (0.81 - 1.58) 0.663
IL1B 1.14 (0.82 - 1.60) 1.12 (0.79 - 1.58) 0.718
IL21 1.48 (1.04 - 2.09) 1.42 (1.00 - 2.02) 0.214
IL23 1.39 (1.00 - 1.94) 1.31 (0.94 - 1.84) 0.324
IL5 1.14 (0.82 - 1.58) 1.11 (0.79 - 1.55) 0.718
IL6 1.20 (0.85 - 1.69) 1.15 (0.81 - 1.64) 0.632
IL7 1.02 (0.72 - 1.43) 0.99 (0.70 - 1.40) 0.965
IP10 1.28 (0.95 - 1.74) 1.33 (0.97 - 1.82) 0.236
CCL2/MCP1 1.81 (1.33 - 2.46) 1.77 (1.29 - 2.43) 0.008
CCL8/MCP2 1.21 (0.90 - 1.62) 1.21 (0.89 - 1.64) 0.452
CCL13/MCP4 1.27 (0.93 - 1.72) 1.22 (0.90 - 1.67) 0.447
CCL22/MDC 1.26 (0.94 - 1.71) 1.18 (0.86 - 1.61) 0.520
CCL4/MIP1B 1.28 (0.94 - 1.74) 1.29 (0.94 - 1.77) 0.324
CCL15/MIP1D 1.33 (0.98 - 1.79) 1.32 (0.97 - 1.80) 0.238
CCL3/MIP1A 1.23 (0.87 - 1.74) 1.29 (0.90 - 1.84) 0.377
SAA 1.23 (0.92 - 1.65) 1.16 (0.86 - 1.56) 0.550
SAP 1.34 (0.98 - 1.83) 1.41 (1.03 - 1.95) 0.158
SCF 1.66 (1.23 - 2.25) 1.64 (1.20 - 2.24) 0.022
CXCL12/SDF1AB 0.52 (0.38 - 0.71) 0.48 (0.35 - 0.66) < 0.001
SEGFR 0.80 (0.58 - 1.10) 0.86 (0.62 - 1.19) 0.554
SGP130 1.11 (0.80 - 1.53) 1.10 (0.79 - 1.54) 0.718
SIL4R 1.22 (0.88 - 1.70) 1.21 (0.87 - 1.70) 0.478
SIL6R 1.37 (1.00 - 1.90) 1.29 (0.92 - 1.80) 0.343
SILRII 0.85 (0.61 - 1.17) 0.92 (0.66 - 1.29) 0.748
STNFRI 1.35 (0.97 - 1.86) 1.30 (0.93 - 1.81) 0.330
STNFRII 1.93 (1.38 - 2.70) 1.73 (1.22 - 2.44) 0.022
SVEGFR2 1.03 (0.74 - 1.42) 1.08 (0.77 - 1.51) 0.758
SVEGFR3 1.58 (1.14 - 2.19) 1.58 (1.13 - 2.20) 0.060
CCL17/TARC 0.89 (0.66 - 1.20) 0.83 (0.61 - 1.13) 0.459
TGFA 1.11 (0.81 - 1.51) 1.10 (0.80 - 1.51) 0.718
TNFA 1.42 (1.04 - 1.93) 1.38 (1.00 - 1.90) 0.200
TPO 1.28 (0.95 - 1.72) 1.18 (0.87 - 1.61) 0.508
TRAIL 1.20 (0.89 - 1.63) 1.17 (0.85 - 1.59) 0.546
VEGF 1.24 (0.92 - 1.68) 1.22 (0.89 - 1.66) 0.447
ADA 0.81 (0.54 - 1.23) 0.95 (0.62 - 1.45) 0.851
AXIN1 1.15 (0.70 - 1.88) 1.40 (0.84 - 2.34) 0.432
BNGF 1.13 (0.75 - 1.71) 1.12 (0.74 - 1.72) 0.720
4E-BP1 1.07 (0.70 - 1.65) 1.13 (0.73 - 1.75) 0.720
CASP8 1.04 (0.68 - 1.60) 1.10 (0.71 - 1.71) 0.758
CCL23/MIP3 1.19 (0.78 - 1.81) 1.13 (0.74 - 1.74) 0.720
CCL25/TECK 1.06 (0.70 - 1.60) 1.01 (0.66 - 1.55) 0.968
CCL28/MEC 0.59 (0.39 - 0.90) 0.59 (0.38 - 0.91) 0.101
CD244 0.92 (0.61 - 1.39) 0.96 (0.63 - 1.47) 0.889
CD40 1.24 (0.82 - 1.88) 1.28 (0.84 - 1.96) 0.476
CD5 2.03 (1.34 - 3.10) 1.93 (1.25 - 2.97) 0.028
CD6 1.45 (0.95 - 2.22) 1.50 (0.97 - 2.32) 0.227
CDCP1 1.29 (0.84 - 1.99) 1.33 (0.85 - 2.07) 0.447
CSF1 1.43 (0.94 - 2.16) 1.38 (0.90 - 2.11) 0.348
CST5 1.06 (0.70 - 1.61) 1.08 (0.70 - 1.66) 0.804
DNER 0.62 (0.41 - 0.94) 0.67 (0.44 - 1.02) 0.227
ENRAGE 1.33 (0.87 - 2.02) 1.30 (0.84 - 2.02) 0.459
FGF19 0.90 (0.59 - 1.36) 0.95 (0.62 - 1.45) 0.851
FGF21 1.34 (0.89 - 2.01) 1.55 (1.02 - 2.37) 0.184
FGF23 1.12 (0.74 - 1.71) 1.07 (0.70 - 1.63) 0.837
FLT3L 0.77 (0.50 - 1.17) 0.79 (0.51 - 1.22) 0.508
HGF 1.64 (1.07 - 2.52) 1.67 (1.08 - 2.60) 0.117
IL10RB 1.33 (0.87 - 2.04) 1.35 (0.87 - 2.08) 0.419
IL12B 1.57 (1.03 - 2.40) 1.62 (1.04 - 2.53) 0.158
IL18R1 1.29 (0.86 - 1.94) 1.26 (0.83 - 1.92) 0.506
IL18 2.16 (1.41 - 3.32) 2.13 (1.36 - 3.32) 0.014
TGFB1/LAB 1.32 (0.87 - 1.99) 1.39 (0.91 - 2.12) 0.330
LIFR 0.81 (0.54 - 1.24) 0.88 (0.57 - 1.35) 0.718
CCL7/MCP3 1.27 (0.83 - 1.94) 1.32 (0.86 - 2.03) 0.447
MMP1 1.00 (0.66 - 1.52) 1.08 (0.70 - 1.66) 0.804
MMP10 0.98 (0.65 - 1.47) 0.89 (0.58 - 1.37) 0.725
NT3 1.02 (0.64 - 1.62) 0.98 (0.61 - 1.58) 0.965
OPG 0.80 (0.53 - 1.23) 0.84 (0.54 - 1.30) 0.632
OSM 1.21 (0.78 - 1.88) 1.28 (0.81 - 2.02) 0.512
PDL1 1.44 (0.95 - 2.18) 1.36 (0.89 - 2.08) 0.377
SLAMF1 1.61 (1.06 - 2.42) 1.60 (1.05 - 2.44) 0.149
ST1A1 1.04 (0.68 - 1.60) 1.18 (0.75 - 1.84) 0.658
STAMPB 1.03 (0.68 - 1.56) 1.12 (0.73 - 1.71) 0.721
TNFB 1.72 (1.13 - 2.64) 1.51 (0.97 - 2.34) 0.227
TNFRSF9 2.00 (1.32 - 3.04) 1.77 (1.15 - 2.72) 0.070
TNFSF14 1.44 (0.94 - 2.21) 1.53 (0.99 - 2.37) 0.221
TRANCE 1.74 (1.15 - 2.65) 1.71 (1.11 - 2.62) 0.096
TWEAK 0.69 (0.46 - 1.06) 0.68 (0.44 - 1.05) 0.238
UPA 1.01 (0.67 - 1.52) 1.01 (0.66 - 1.54) 0.976
VEGFA 1.69 (1.11 - 2.55) 1.67 (1.09 - 2.55) 0.101
IL29/IFNL1 1.22 (0.81 - 1.82) 1.22 (0.81 - 1.86) 0.549
IL33 1.18 (0.79 - 1.77) 1.10 (0.72 - 1.66) 0.758
IL4 2.01 (1.28 - 3.15) 2.09 (1.31 - 3.34) 0.022
TSLP 0.99 (0.61 - 1.61) 0.91 (0.55 - 1.52) 0.804
IL10RA 1.03 (0.55 - 1.93) 0.87 (0.45 - 1.67) 0.758
IL17C 1.61 (0.81 - 3.19) 1.57 (0.76 - 3.23) 0.452
SIRT2 1.38 (0.73 - 2.63) 1.70 (0.87 - 3.33) 0.325
OR1 is adjusted for age, sex, and study site.
OR2 is further adjusted for smoking (never/past/current), alcohol use (never/<weekly, <150g/week, 150-<300g/week, 300+ g/week), fasting status at
blood draw(<8 hrs/ 8+ hrs), and low PA.
Adjusted P-Values presented for OR2 only, and bold face denotes FDR P-value < 0.05.
Table S6. Associations between hypertriglyceridemia and marker quantiles
OR1 (95% CI) OR2 (95% CI) FDR P-Value
CCL21/6CKINE 0.93 (0.68 - 1.26) 0.93 (0.68 - 1.27) 0.789
CXCL13/BCA1 1.26 (0.94 - 1.70) 1.31 (0.97 - 1.77) 0.224
CCL19/MIP3B 1.88 (1.38 - 2.55) 1.88 (1.38 - 2.56) 0.002
CCL20/MIP3A 1.19 (0.88 - 1.61) 1.20 (0.88 - 1.63) 0.442
CRP 1.79 (1.32 - 2.44) 1.75 (1.29 - 2.39) 0.006
CCL27/CTACK 1.09 (0.81 - 1.48) 1.09 (0.81 - 1.49) 0.770
CXCL11/ITAC 1.03 (0.77 - 1.39) 1.06 (0.79 - 1.44) 0.797
CXCL6/GCP2 1.24 (0.92 - 1.69) 1.24 (0.91 - 1.69) 0.340
CXCL9/MIG 1.06 (0.78 - 1.44) 1.04 (0.76 - 1.43) 0.866
EGF 1.35 (0.99 - 1.82) 1.43 (1.05 - 1.94) 0.094
CXCL5/ENA78 1.19 (0.88 - 1.61) 1.30 (0.96 - 1.77) 0.224
CCL24/EOTAXIN2 0.94 (0.69 - 1.27) 0.95 (0.70 - 1.30) 0.848
CCL11/EOTAXIN 1.03 (0.76 - 1.40) 1.08 (0.79 - 1.48) 0.789
FGF2 0.85 (0.63 - 1.15) 0.82 (0.60 - 1.12) 0.408
CX3CL1/FRACTALKINE 0.75 (0.53 - 1.05) 0.72 (0.51 - 1.01) 0.185
GCSF 0.99 (0.73 - 1.34) 1.00 (0.74 - 1.35) 0.986
GMCSF 0.76 (0.54 - 1.06) 0.74 (0.53 - 1.04) 0.224
CXCL1/GRO 0.99 (0.74 - 1.34) 1.02 (0.76 - 1.38) 0.931
IL16 1.41 (1.04 - 1.92) 1.39 (1.02 - 1.91) 0.133
IL1RA 0.77 (0.57 - 1.05) 0.76 (0.56 - 1.04) 0.224
IL8 1.02 (0.74 - 1.39) 1.06 (0.77 - 1.45) 0.833
IL10 1.01 (0.72 - 1.42) 1.03 (0.73 - 1.46) 0.931
IL12p70 0.66 (0.47 - 0.92) 0.66 (0.47 - 0.93) 0.069
IL13 0.61 (0.44 - 0.86) 0.60 (0.43 - 0.85) 0.022
IL17A 0.63 (0.46 - 0.88) 0.63 (0.45 - 0.88) 0.033
IL1B 0.63 (0.44 - 0.89) 0.60 (0.42 - 0.86) 0.027
IL21 0.86 (0.60 - 1.23) 0.86 (0.60 - 1.23) 0.640
IL23 0.69 (0.49 - 0.96) 0.68 (0.49 - 0.96) 0.109
IL5 0.56 (0.40 - 0.78) 0.56 (0.39 - 0.78) 0.008
IL6 0.69 (0.48 - 0.98) 0.68 (0.47 - 0.98) 0.140
IL7 0.89 (0.63 - 1.26) 0.87 (0.61 - 1.23) 0.665
IP10 1.06 (0.78 - 1.43) 1.11 (0.82 - 1.51) 0.717
CCL2/MCP1 1.61 (1.19 - 2.19) 1.62 (1.19 - 2.21) 0.015
CCL8/MCP2 0.87 (0.64 - 1.17) 0.88 (0.65 - 1.18) 0.621
CCL13/MCP4 1.06 (0.78 - 1.44) 1.10 (0.80 - 1.50) 0.770
CCL22/MDC 1.03 (0.76 - 1.38) 1.07 (0.79 - 1.45) 0.792
CCL4/MIP1B 1.20 (0.89 - 1.64) 1.20 (0.88 - 1.65) 0.442
CCL15/MIP1D 1.34 (0.99 - 1.81) 1.31 (0.97 - 1.78) 0.224
CCL3/MIP1A 1.01 (0.72 - 1.44) 1.01 (0.71 - 1.43) 0.982
SAA 1.45 (1.08 - 1.95) 1.46 (1.08 - 1.97) 0.057
SAP 2.45 (1.79 - 3.37) 2.39 (1.73 - 3.29) < 0.001
SCF 1.54 (1.13 - 2.09) 1.55 (1.13 - 2.11) 0.032
CXCL12/SDF1AB 0.43 (0.32 - 0.58) 0.42 (0.31 - 0.57) < 0.001
SEGFR 1.19 (0.87 - 1.64) 1.19 (0.86 - 1.64) 0.495
SGP130 1.23 (0.89 - 1.71) 1.21 (0.87 - 1.67) 0.461
SIL4R 0.89 (0.64 - 1.23) 0.89 (0.64 - 1.23) 0.717
SIL6R 1.73 (1.25 - 2.40) 1.71 (1.22 - 2.38) 0.013
SILRII 1.24 (0.89 - 1.73) 1.25 (0.89 - 1.74) 0.376
STNFRI 1.55 (1.12 - 2.14) 1.57 (1.13 - 2.19) 0.033
STNFRII 1.32 (0.95 - 1.83) 1.33 (0.96 - 1.86) 0.224
SVEGFR2 1.34 (0.96 - 1.85) 1.34 (0.96 - 1.86) 0.224
SVEGFR3 1.83 (1.31 - 2.55) 1.80 (1.29 - 2.52) 0.007
CCL17/TARC 0.57 (0.42 - 0.77) 0.58 (0.43 - 0.79) 0.006
TGFA 1.06 (0.78 - 1.44) 1.07 (0.78 - 1.46) 0.795
TNFA 1.28 (0.95 - 1.74) 1.30 (0.95 - 1.77) 0.229
TPO 0.99 (0.73 - 1.34) 0.99 (0.73 - 1.34) 0.974
TRAIL 1.76 (1.30 - 2.37) 1.78 (1.31 - 2.42) 0.005
VEGF 0.94 (0.70 - 1.27) 0.96 (0.71 - 1.30) 0.862
ADA 1.07 (0.70 - 1.66) 1.10 (0.71 - 1.71) 0.791
AXIN1 1.32 (0.80 - 2.19) 1.41 (0.84 - 2.36) 0.372
BNGF 1.15 (0.74 - 1.78) 1.12 (0.72 - 1.74) 0.789
4E-BP1 0.94 (0.59 - 1.48) 0.97 (0.61 - 1.54) 0.931
CASP8 1.78 (1.13 - 2.81) 1.78 (1.12 - 2.82) 0.057
CCL23/MIP3 0.88 (0.57 - 1.36) 0.86 (0.56 - 1.33) 0.717
CCL25/TECK 0.69 (0.44 - 1.08) 0.68 (0.43 - 1.08) 0.234
CCL28/MEC 0.74 (0.48 - 1.16) 0.74 (0.47 - 1.16) 0.372
CD244 1.20 (0.77 - 1.86) 1.11 (0.71 - 1.73) 0.789
CD40 1.36 (0.86 - 2.13) 1.39 (0.88 - 2.19) 0.333
CD5 2.21 (1.43 - 3.43) 2.21 (1.42 - 3.44) 0.006
CD6 1.84 (1.18 - 2.88) 1.79 (1.14 - 2.81) 0.048
CDCP1 1.12 (0.71 - 1.77) 1.13 (0.71 - 1.78) 0.789
CSF1 0.95 (0.62 - 1.46) 0.90 (0.58 - 1.40) 0.790
CST5 1.40 (0.91 - 2.18) 1.39 (0.89 - 2.17) 0.312
DNER 0.93 (0.60 - 1.43) 0.95 (0.61 - 1.48) 0.894
ENRAGE 1.91 (1.22 - 2.99) 1.84 (1.17 - 2.90) 0.037
FGF19 1.07 (0.70 - 1.66) 1.08 (0.70 - 1.67) 0.822
FGF21 1.16 (0.75 - 1.78) 1.14 (0.74 - 1.78) 0.765
FGF23 1.50 (0.97 - 2.33) 1.41 (0.90 - 2.20) 0.295
FLT3L 0.82 (0.52 - 1.28) 0.78 (0.49 - 1.22) 0.472
HGF 2.09 (1.33 - 3.29) 2.13 (1.34 - 3.37) 0.011
IL10RB 2.15 (1.37 - 3.36) 2.07 (1.31 - 3.27) 0.013
IL12B 1.48 (0.95 - 2.30) 1.35 (0.86 - 2.13) 0.372
IL18R1 2.24 (1.43 - 3.51) 2.14 (1.36 - 3.36) 0.009
IL18 1.56 (1.01 - 2.41) 1.55 (0.99 - 2.41) 0.175
TGFB1/LAB 1.52 (0.99 - 2.35) 1.49 (0.97 - 2.31) 0.219
LIFR 0.71 (0.46 - 1.10) 0.68 (0.43 - 1.06) 0.224
CCL7/MCP3 1.19 (0.77 - 1.84) 1.17 (0.75 - 1.82) 0.717
MMP1 0.97 (0.63 - 1.49) 0.98 (0.64 - 1.52) 0.971
MMP10 1.06 (0.68 - 1.63) 1.11 (0.71 - 1.74) 0.789
NT3 2.21 (1.39 - 3.52) 2.21 (1.38 - 3.53) 0.009
OPG 0.73 (0.47 - 1.14) 0.73 (0.47 - 1.14) 0.340
OSM 1.14 (0.71 - 1.84) 1.18 (0.73 - 1.90) 0.717
PDL1 1.24 (0.80 - 1.91) 1.24 (0.80 - 1.93) 0.546
SLAMF1 1.21 (0.78 - 1.85) 1.17 (0.76 - 1.81) 0.717
ST1A1 1.18 (0.75 - 1.85) 1.17 (0.74 - 1.85) 0.717
STAMPB 1.42 (0.91 - 2.19) 1.46 (0.94 - 2.26) 0.228
TNFB 1.71 (1.10 - 2.66) 1.59 (1.02 - 2.49) 0.141
TNFRSF9 1.98 (1.26 - 3.10) 1.95 (1.24 - 3.09) 0.024
TNFSF14 1.41 (0.91 - 2.20) 1.49 (0.95 - 2.34) 0.224
TRANCE 3.38 (2.15 - 5.32) 3.38 (2.14 - 5.35) < 0.001
TWEAK 0.77 (0.50 - 1.19) 0.71 (0.46 - 1.10) 0.277
UPA 0.80 (0.51 - 1.23) 0.80 (0.52 - 1.25) 0.546
VEGFA 1.99 (1.29 - 3.07) 1.99 (1.28 - 3.08) 0.015
IL29/IFNL1 0.96 (0.63 - 1.45) 0.98 (0.65 - 1.49) 0.965
IL33 0.90 (0.59 - 1.36) 0.90 (0.59 - 1.38) 0.789
IL4 0.80 (0.48 - 1.33) 0.76 (0.45 - 1.27) 0.495
TSLP 1.14 (0.71 - 1.85) 1.10 (0.67 - 1.80) 0.803
IL10RA 0.86 (0.44 - 1.68) 0.83 (0.41 - 1.66) 0.789
IL17C 1.24 (0.60 - 2.54) 1.21 (0.57 - 2.57) 0.789
SIRT2 0.54 (0.25 - 1.15) 0.62 (0.28 - 1.36) 0.423
OR1 is adjusted for age, sex, and study site.
OR2 is further adjusted for smoking (never/past/current), alcohol use (never/<weekly, <150g/week, 150-<300g/week, 300+ g/week), fasting status at
blood draw(<8 hrs/ 8+ hrs), and low PA.
Adjusted P-Values presented for OR2 only, and bold face denotes FDR P-value < 0.05.
Table S7. Associations between hyperglycemia and marker quantiles.
OR1 (95% CI) OR2 (95% CI) FDR P-Value
CCL21/6CKINE 1.06 (0.77 - 1.45) 1.05 (0.75 - 1.45) 0.970
CXCL13/BCA1 1.12 (0.83 - 1.53) 1.08 (0.78 - 1.48) 0.970
CCL19/MIP3B 1.06 (0.78 - 1.44) 1.09 (0.79 - 1.50) 0.970
CCL20/MIP3A 1.22 (0.89 - 1.66) 1.17 (0.85 - 1.62) 0.937
CRP 1.45 (1.06 - 1.98) 1.44 (1.04 - 1.98) 0.332
CCL27/CTACK 0.95 (0.70 - 1.29) 0.85 (0.62 - 1.17) 0.937
CXCL11/ITAC 1.18 (0.88 - 1.60) 1.00 (0.73 - 1.37) 0.998
CXCL6/GCP2 1.19 (0.88 - 1.63) 1.05 (0.76 - 1.46) 0.970
CXCL9/MIG 1.22 (0.90 - 1.67) 1.15 (0.84 - 1.59) 0.937
EGF 1.24 (0.90 - 1.70) 1.26 (0.90 - 1.75) 0.695
CXCL5/ENA78 1.08 (0.80 - 1.46) 0.97 (0.71 - 1.33) 0.970
CCL24/EOTAXIN2 0.97 (0.71 - 1.30) 1.05 (0.76 - 1.43) 0.970
CCL11/EOTAXIN 1.09 (0.80 - 1.49) 1.11 (0.80 - 1.53) 0.970
FGF2 1.07 (0.79 - 1.46) 1.06 (0.77 - 1.46) 0.970
CX3CL1/FRACTALKINE 0.88 (0.63 - 1.23) 0.92 (0.65 - 1.31) 0.970
GCSF 0.82 (0.60 - 1.12) 0.77 (0.56 - 1.06) 0.636
GMCSF 0.86 (0.62 - 1.20) 0.93 (0.66 - 1.31) 0.970
CXCL1/GRO 1.09 (0.80 - 1.49) 0.99 (0.72 - 1.37) 0.998
IL16 1.20 (0.88 - 1.65) 1.27 (0.91 - 1.76) 0.687
IL1RA 1.06 (0.78 - 1.43) 0.99 (0.72 - 1.36) 0.998
IL8 0.98 (0.71 - 1.35) 0.96 (0.68 - 1.34) 0.970
IL10 0.89 (0.63 - 1.26) 0.92 (0.64 - 1.32) 0.970
IL12p70 0.94 (0.67 - 1.32) 0.97 (0.68 - 1.37) 0.970
IL13 0.90 (0.64 - 1.25) 0.96 (0.68 - 1.35) 0.970
IL17A 0.84 (0.60 - 1.17) 0.87 (0.61 - 1.23) 0.937
IL1B 0.86 (0.61 - 1.22) 0.92 (0.64 - 1.31) 0.970
IL21 0.98 (0.69 - 1.39) 0.98 (0.68 - 1.41) 0.998
IL23 0.78 (0.56 - 1.09) 0.87 (0.61 - 1.23) 0.937
IL5 0.93 (0.67 - 1.30) 1.04 (0.74 - 1.46) 0.970
IL6 1.01 (0.71 - 1.43) 1.09 (0.76 - 1.57) 0.970
IL7 0.83 (0.59 - 1.16) 0.87 (0.61 - 1.23) 0.937
IP10 1.52 (1.11 - 2.07) 1.27 (0.92 - 1.75) 0.655
CCL2/MCP1 1.00 (0.74 - 1.37) 1.03 (0.74 - 1.43) 0.970
CCL8/MCP2 1.06 (0.79 - 1.44) 1.04 (0.76 - 1.42) 0.970
CCL13/MCP4 1.05 (0.77 - 1.43) 1.08 (0.78 - 1.49) 0.970
CCL22/MDC 1.05 (0.77 - 1.42) 1.05 (0.76 - 1.44) 0.970
CCL4/MIP1B 0.96 (0.70 - 1.32) 0.90 (0.65 - 1.25) 0.970
CCL15/MIP1D 1.05 (0.77 - 1.42) 1.09 (0.79 - 1.49) 0.970
CCL3/MIP1A 1.18 (0.83 - 1.67) 1.08 (0.75 - 1.55) 0.970
SAA 1.62 (1.20 - 2.21) 1.58 (1.15 - 2.17) 0.185
SAP 1.47 (1.07 - 2.03) 1.49 (1.07 - 2.09) 0.332
SCF 0.88 (0.64 - 1.19) 0.93 (0.68 - 1.29) 0.970
CXCL12/SDF1AB 0.86 (0.63 - 1.16) 0.81 (0.59 - 1.11) 0.730
SEGFR 1.30 (0.93 - 1.82) 1.24 (0.88 - 1.75) 0.804
SGP130 1.17 (0.84 - 1.65) 1.19 (0.84 - 1.69) 0.937
SIL4R 0.87 (0.62 - 1.21) 0.85 (0.60 - 1.20) 0.937
SIL6R 0.99 (0.71 - 1.38) 1.00 (0.70 - 1.42) 0.998
SILRII 1.65 (1.17 - 2.32) 1.61 (1.13 - 2.30) 0.232
STNFRI 0.93 (0.66 - 1.29) 0.96 (0.68 - 1.36) 0.970
STNFRII 0.90 (0.64 - 1.26) 0.90 (0.63 - 1.27) 0.970
SVEGFR2 1.13 (0.81 - 1.57) 1.06 (0.75 - 1.49) 0.970
SVEGFR3 1.07 (0.76 - 1.51) 1.01 (0.71 - 1.44) 0.998
CCL17/TARC 0.78 (0.58 - 1.06) 0.72 (0.52 - 0.98) 0.350
TGFA 0.99 (0.72 - 1.35) 1.01 (0.73 - 1.40) 0.998
TNFA 1.30 (0.95 - 1.79) 1.30 (0.93 - 1.81) 0.636
TPO 0.71 (0.52 - 0.96) 0.70 (0.51 - 0.96) 0.332
TRAIL 1.05 (0.77 - 1.42) 1.04 (0.76 - 1.42) 0.970
VEGF 0.95 (0.70 - 1.29) 0.94 (0.68 - 1.29) 0.970
ADA 1.94 (1.26 - 2.98) 2.22 (1.40 - 3.54) 0.042
AXIN1 1.48 (0.88 - 2.49) 1.61 (0.92 - 2.81) 0.597
BNGF 1.01 (0.66 - 1.55) 1.12 (0.71 - 1.77) 0.970
4E-BP1 1.78 (1.14 - 2.77) 1.68 (1.04 - 2.70) 0.332
CASP8 1.17 (0.76 - 1.80) 1.09 (0.69 - 1.73) 0.970
CCL23/MIP3 0.72 (0.47 - 1.10) 0.70 (0.44 - 1.10) 0.636
CCL25/TECK 1.41 (0.93 - 2.14) 1.52 (0.97 - 2.39) 0.486
CCL28/MEC 0.75 (0.49 - 1.15) 0.79 (0.50 - 1.25) 0.937
CD244 1.27 (0.83 - 1.95) 1.35 (0.85 - 2.13) 0.743
CD40 1.42 (0.92 - 2.19) 1.38 (0.87 - 2.21) 0.695
CD5 1.25 (0.82 - 1.91) 1.17 (0.74 - 1.86) 0.970
CD6 1.28 (0.84 - 1.96) 1.14 (0.72 - 1.80) 0.970
CDCP1 1.52 (0.98 - 2.36) 1.77 (1.09 - 2.85) 0.332
CSF1 1.03 (0.67 - 1.58) 1.11 (0.70 - 1.77) 0.970
CST5 1.17 (0.77 - 1.78) 1.07 (0.68 - 1.69) 0.970
DNER 1.09 (0.72 - 1.67) 1.03 (0.65 - 1.64) 0.998
ENRAGE 0.97 (0.64 - 1.46) 1.00 (0.64 - 1.56) 0.998
FGF19 0.68 (0.44 - 1.03) 0.71 (0.45 - 1.11) 0.655
FGF21 1.12 (0.74 - 1.71) 0.99 (0.63 - 1.57) 0.998
FGF23 0.89 (0.58 - 1.36) 0.95 (0.60 - 1.49) 0.970
FLT3L 1.52 (0.98 - 2.34) 1.57 (0.98 - 2.52) 0.478
HGF 1.39 (0.90 - 2.14) 1.63 (1.02 - 2.61) 0.350
IL10RB 1.22 (0.80 - 1.88) 1.24 (0.78 - 1.97) 0.937
IL12B 1.40 (0.90 - 2.17) 1.26 (0.78 - 2.02) 0.937
IL18R1 2.06 (1.34 - 3.17) 2.63 (1.65 - 4.19) 0.005
IL18 1.32 (0.86 - 2.02) 1.49 (0.94 - 2.35) 0.597
TGFB1/LAB 1.35 (0.89 - 2.06) 1.24 (0.79 - 1.97) 0.937
LIFR 1.90 (1.22 - 2.96) 1.68 (1.05 - 2.68) 0.332
CCL7/MCP3 1.47 (0.95 - 2.26) 1.70 (1.07 - 2.69) 0.332
MMP1 0.98 (0.64 - 1.51) 1.00 (0.64 - 1.58) 0.998
MMP10 0.93 (0.61 - 1.42) 1.07 (0.68 - 1.70) 0.970
NT3 0.71 (0.44 - 1.15) 0.70 (0.42 - 1.16) 0.695
OPG 1.14 (0.75 - 1.75) 1.24 (0.79 - 1.96) 0.937
OSM 0.78 (0.50 - 1.22) 0.84 (0.52 - 1.38) 0.970
PDL1 1.33 (0.87 - 2.03) 1.22 (0.77 - 1.93) 0.937
SLAMF1 0.90 (0.59 - 1.38) 0.81 (0.51 - 1.29) 0.937
ST1A1 1.15 (0.74 - 1.79) 1.00 (0.62 - 1.62) 0.998
STAMPB 1.20 (0.78 - 1.85) 1.26 (0.79 - 2.01) 0.937
TNFB 1.42 (0.92 - 2.20) 1.45 (0.91 - 2.33) 0.636
TNFRSF9 0.99 (0.64 - 1.53) 0.92 (0.58 - 1.47) 0.970
TNFSF14 1.02 (0.67 - 1.55) 1.06 (0.67 - 1.67) 0.970
TRANCE 1.47 (0.95 - 2.26) 1.42 (0.89 - 2.26) 0.655
TWEAK 1.01 (0.66 - 1.53) 0.90 (0.57 - 1.40) 0.970
UPA 0.74 (0.48 - 1.12) 0.83 (0.53 - 1.29) 0.937
VEGFA 1.04 (0.68 - 1.58) 1.08 (0.69 - 1.71) 0.970
IL29/IFNL1 0.95 (0.62 - 1.45) 1.00 (0.64 - 1.56) 0.998
IL33 0.95 (0.62 - 1.46) 1.06 (0.67 - 1.66) 0.970
IL4 1.08 (0.67 - 1.75) 1.23 (0.74 - 2.05) 0.937
TSLP 1.15 (0.70 - 1.89) 1.23 (0.73 - 2.07) 0.943
IL10RA 1.25 (0.66 - 2.37) 1.34 (0.66 - 2.72) 0.937
IL17C 0.68 (0.31 - 1.49) 0.76 (0.32 - 1.80) 0.970
SIRT2 1.21 (0.59 - 2.44) 1.24 (0.57 - 2.66) 0.970
OR1 is adjusted for age, sex, and study site.
OR2 is further adjusted for smoking (never/past/current), alcohol use (never/<weekly, <150g/week, 150-<300g/week, 300+ g/week), fasting status at
blood draw(<8 hrs/ 8+ hrs), and low PA.
Adjusted P-Values presented for OR2 only, and bold face denotes FDR P-value < 0.05.
Table S8. Associations between hypertension and marker quantiles.
OR1 (95% CI) OR2 (95% CI) FDR P-Value
CCL21/6CKINE 1.06 (0.80 - 1.39) 1.10 (0.83 - 1.45) 0.857
CXCL13/BCA1 1.00 (0.76 - 1.31) 1.01 (0.77 - 1.33) 0.954
CCL19/MIP3B 1.23 (0.94 - 1.62) 1.27 (0.97 - 1.68) 0.510
CCL20/MIP3A 1.12 (0.86 - 1.46) 1.18 (0.90 - 1.55) 0.616
CRP 1.02 (0.78 - 1.34) 1.07 (0.81 - 1.40) 0.936
CCL27/CTACK 0.68 (0.52 - 0.89) 0.70 (0.53 - 0.92) 0.192
CXCL11/ITAC 0.99 (0.76 - 1.30) 0.98 (0.74 - 1.29) 0.954
CXCL6/GCP2 0.87 (0.67 - 1.14) 0.89 (0.68 - 1.17) 0.799
CXCL9/MIG 0.98 (0.75 - 1.29) 0.98 (0.74 - 1.29) 0.954
EGF 0.99 (0.76 - 1.31) 0.97 (0.74 - 1.28) 0.954
CXCL5/ENA78 0.91 (0.70 - 1.19) 0.95 (0.73 - 1.25) 0.937
CCL24/EOTAXIN2 1.45 (1.10 - 1.89) 1.52 (1.15 - 2.00) 0.145
CCL11/EOTAXIN 1.15 (0.88 - 1.51) 1.24 (0.94 - 1.63) 0.521
FGF2 0.94 (0.72 - 1.24) 0.96 (0.73 - 1.26) 0.937
CX3CL1/FRACTALKINE 0.73 (0.54 - 0.98) 0.75 (0.56 - 1.01) 0.460
GCSF 0.97 (0.75 - 1.27) 0.99 (0.76 - 1.30) 0.954
GMCSF 0.74 (0.55 - 0.99) 0.71 (0.53 - 0.96) 0.326
CXCL1/GRO 0.78 (0.59 - 1.02) 0.80 (0.61 - 1.06) 0.521
IL16 0.99 (0.75 - 1.31) 0.99 (0.75 - 1.31) 0.954
IL1RA 0.83 (0.63 - 1.08) 0.84 (0.64 - 1.10) 0.581
IL8 0.76 (0.57 - 1.01) 0.79 (0.59 - 1.06) 0.521
IL10 0.78 (0.58 - 1.05) 0.77 (0.57 - 1.05) 0.510
IL12p70 0.80 (0.60 - 1.08) 0.81 (0.60 - 1.09) 0.521
IL13 0.80 (0.60 - 1.07) 0.80 (0.59 - 1.08) 0.521
IL17A 0.86 (0.64 - 1.14) 0.88 (0.66 - 1.18) 0.759
IL1B 0.73 (0.55 - 0.99) 0.71 (0.53 - 0.96) 0.327
IL21 0.67 (0.49 - 0.91) 0.67 (0.49 - 0.91) 0.192
IL23 0.85 (0.63 - 1.13) 0.85 (0.63 - 1.14) 0.629
IL5 0.64 (0.48 - 0.86) 0.65 (0.48 - 0.87) 0.145
IL6 0.82 (0.61 - 1.10) 0.84 (0.62 - 1.13) 0.624
IL7 0.89 (0.66 - 1.20) 0.90 (0.66 - 1.21) 0.855
IP10 0.75 (0.58 - 0.99) 0.75 (0.57 - 0.99) 0.375
CCL2/MCP1 1.25 (0.95 - 1.63) 1.26 (0.95 - 1.65) 0.521
CCL8/MCP2 1.14 (0.88 - 1.49) 1.16 (0.88 - 1.52) 0.648
CCL13/MCP4 1.28 (0.97 - 1.69) 1.32 (1.00 - 1.75) 0.442
CCL22/MDC 0.98 (0.75 - 1.28) 1.05 (0.80 - 1.38) 0.937
CCL4/MIP1B 0.78 (0.59 - 1.03) 0.80 (0.60 - 1.06) 0.521
CCL15/MIP1D 1.12 (0.86 - 1.46) 1.14 (0.87 - 1.49) 0.753
CCL3/MIP1A 0.88 (0.65 - 1.18) 0.89 (0.65 - 1.21) 0.842
SAA 1.18 (0.91 - 1.55) 1.22 (0.93 - 1.60) 0.521
SAP 1.14 (0.86 - 1.50) 1.09 (0.82 - 1.45) 0.881
SCF 1.21 (0.93 - 1.59) 1.27 (0.97 - 1.67) 0.510
CXCL12/SDF1AB 0.97 (0.74 - 1.27) 0.98 (0.75 - 1.29) 0.954
SEGFR 1.00 (0.74 - 1.34) 0.97 (0.72 - 1.31) 0.954
SGP130 1.10 (0.82 - 1.47) 1.10 (0.82 - 1.49) 0.857
SIL4R 0.96 (0.72 - 1.28) 0.94 (0.70 - 1.27) 0.937
SIL6R 0.93 (0.70 - 1.24) 0.91 (0.68 - 1.22) 0.857
SILRII 1.13 (0.84 - 1.51) 1.09 (0.81 - 1.47) 0.890
STNFRI 0.82 (0.61 - 1.10) 0.88 (0.65 - 1.18) 0.756
STNFRII 0.76 (0.57 - 1.03) 0.80 (0.59 - 1.08) 0.521
SVEGFR2 0.89 (0.66 - 1.20) 0.87 (0.65 - 1.18) 0.756
SVEGFR3 1.17 (0.87 - 1.56) 1.20 (0.89 - 1.61) 0.616
CCL17/TARC 0.73 (0.56 - 0.96) 0.79 (0.60 - 1.04) 0.510
TGFA 0.70 (0.53 - 0.92) 0.70 (0.53 - 0.93) 0.203
TNFA 1.06 (0.80 - 1.39) 1.09 (0.83 - 1.45) 0.857
TPO 1.08 (0.83 - 1.42) 1.09 (0.83 - 1.43) 0.857
TRAIL 1.18 (0.90 - 1.54) 1.22 (0.93 - 1.60) 0.521
VEGF 1.11 (0.85 - 1.46) 1.17 (0.89 - 1.54) 0.629
ADA 1.00 (0.69 - 1.45) 0.98 (0.67 - 1.43) 0.954
AXIN1 1.15 (0.73 - 1.81) 1.07 (0.68 - 1.70) 0.937
BNGF 1.31 (0.90 - 1.91) 1.27 (0.87 - 1.86) 0.592
4E-BP1 0.96 (0.65 - 1.41) 0.96 (0.65 - 1.41) 0.954
CASP8 1.21 (0.83 - 1.76) 1.15 (0.79 - 1.69) 0.854
CCL23/MIP3 0.85 (0.58 - 1.24) 0.84 (0.58 - 1.22) 0.756
CCL25/TECK 0.88 (0.61 - 1.28) 0.90 (0.62 - 1.31) 0.890
CCL28/MEC 0.81 (0.55 - 1.18) 0.77 (0.53 - 1.14) 0.573
CD244 0.89 (0.61 - 1.28) 0.88 (0.61 - 1.28) 0.857
CD40 1.05 (0.73 - 1.52) 1.04 (0.72 - 1.51) 0.954
CD5 1.07 (0.74 - 1.56) 1.08 (0.74 - 1.58) 0.937
CD6 1.07 (0.73 - 1.55) 1.02 (0.70 - 1.49) 0.954
CDCP1 1.13 (0.77 - 1.66) 1.11 (0.75 - 1.64) 0.912
CSF1 1.07 (0.74 - 1.55) 1.04 (0.71 - 1.51) 0.954
CST5 1.10 (0.76 - 1.59) 1.07 (0.74 - 1.56) 0.937
DNER 0.83 (0.57 - 1.21) 0.82 (0.56 - 1.19) 0.648
ENRAGE 0.80 (0.55 - 1.16) 0.77 (0.53 - 1.13) 0.564
FGF19 1.00 (0.68 - 1.45) 0.95 (0.65 - 1.40) 0.954
FGF21 1.37 (0.94 - 1.99) 1.29 (0.88 - 1.89) 0.573
FGF23 1.07 (0.74 - 1.54) 1.06 (0.73 - 1.53) 0.937
FLT3L 1.10 (0.75 - 1.60) 1.07 (0.74 - 1.57) 0.937
HGF 0.95 (0.65 - 1.39) 0.94 (0.64 - 1.39) 0.937
IL10RB 1.32 (0.91 - 1.91) 1.33 (0.91 - 1.93) 0.521
IL12B 0.82 (0.56 - 1.19) 0.82 (0.56 - 1.20) 0.673
IL18R1 1.54 (1.06 - 2.24) 1.50 (1.03 - 2.19) 0.364
IL18 1.14 (0.78 - 1.65) 1.11 (0.76 - 1.62) 0.893
TGFB1/LAB 1.07 (0.74 - 1.55) 1.02 (0.70 - 1.48) 0.954
LIFR 1.30 (0.90 - 1.89) 1.25 (0.86 - 1.82) 0.617
CCL7/MCP3 0.74 (0.51 - 1.08) 0.72 (0.49 - 1.06) 0.510
MMP1 0.84 (0.58 - 1.22) 0.80 (0.55 - 1.18) 0.629
MMP10 0.93 (0.64 - 1.35) 0.94 (0.64 - 1.37) 0.937
NT3 1.03 (0.68 - 1.55) 1.02 (0.67 - 1.55) 0.954
OPG 0.95 (0.65 - 1.38) 0.91 (0.62 - 1.33) 0.922
OSM 0.45 (0.30 - 0.68) 0.45 (0.30 - 0.68) 0.017
PDL1 1.08 (0.75 - 1.57) 1.08 (0.74 - 1.56) 0.937
SLAMF1 0.86 (0.60 - 1.25) 0.84 (0.58 - 1.22) 0.753
ST1A1 1.07 (0.73 - 1.57) 1.03 (0.70 - 1.52) 0.954
STAMPB 0.96 (0.66 - 1.40) 0.95 (0.65 - 1.38) 0.937
TNFB 0.72 (0.49 - 1.06) 0.72 (0.49 - 1.06) 0.510
TNFRSF9 0.77 (0.53 - 1.13) 0.79 (0.54 - 1.16) 0.616
TNFSF14 0.57 (0.39 - 0.84) 0.58 (0.39 - 0.85) 0.162
TRANCE 1.48 (1.02 - 2.15) 1.51 (1.03 - 2.20) 0.362
TWEAK 0.97 (0.67 - 1.42) 1.01 (0.69 - 1.48) 0.954
UPA 0.84 (0.58 - 1.22) 0.88 (0.60 - 1.29) 0.857
VEGFA 0.97 (0.67 - 1.40) 0.91 (0.63 - 1.33) 0.922
IL29/IFNL1 1.30 (0.90 - 1.89) 1.32 (0.90 - 1.92) 0.521
IL33 1.06 (0.73 - 1.55) 1.02 (0.69 - 1.49) 0.954
IL4 0.91 (0.60 - 1.39) 0.92 (0.60 - 1.42) 0.937
TSLP 0.91 (0.59 - 1.41) 0.91 (0.58 - 1.43) 0.937
IL10RA 0.61 (0.35 - 1.08) 0.64 (0.36 - 1.15) 0.521
IL17C 1.92 (0.95 - 3.86) 1.97 (0.96 - 4.05) 0.483
SIRT2 1.37 (0.75 - 2.50) 1.32 (0.71 - 2.46) 0.756
OR1 is adjusted for age, sex, and study site.
OR2 is further adjusted for smoking (never/past/current), alcohol use (never/<weekly, <150g/week, 150-<300g/week, 300+ g/week), fasting status at
blood draw(<8 hrs/ 8+ hrs), and low PA.
Adjusted P-Values presented for OR2 only, and bold face denotes FDR P-value < 0.05.
Table S9. Participants per marker quantile with given characteristic.Marker
- + - + - + - + - + - + - +
6CKINE
Q1 265 (42.6) 62 (40.8) 255 (43.6) 61 (38.1) 243 (42.8) 78 (42.9) 259 (44.6) 68 (35.2) 237 (43.6) 86 (39.4) 134 (43.6) 186 (42.0) 225 (42.1) 69 (42.9)
Q2 122 (19.6) 27 (17.8) 114 (19.5) 31 (19.4) 110 (19.4) 34 (18.7) 111 (19.1) 38 (19.7) 106 (19.5) 41 (18.8) 59 (19.2) 87 (19.6) 107 (20.0) 25 (15.5)
Q3 112 (18.0) 37 (24.3) 115 (19.7) 27 (16.9) 102 (18.0) 40 (22.0) 104 (17.9) 45 (23.3) 98 (18.0) 47 (21.6) 49 (16.0) 93 (21.0) 97 (18.2) 35 (21.7)
Q4 123 (19.8) 26 (17.1) 101 (17.3) 41 (25.6) 113 (19.9) 30 (16.5) 107 (18.4) 42 (21.8) 103 (18.9) 44 (20.2) 65 (21.2) 77 (17.4) 105 (19.7) 32 (19.9)
BCA1
Q1 169 (27.2) 24 (15.8) 151 (25.8) 35 (21.9) 158 (27.8) 31 (17.0) 158 (27.2) 35 (18.1) 145 (26.7) 43 (19.7) 75 (24.4) 113 (25.5) 129 (24.2) 37 (23.0)
Q2 145 (23.3) 49 (32.2) 153 (26.2) 33 (20.6) 136 (23.9) 53 (29.1) 142 (24.4) 52 (26.9) 138 (25.4) 53 (24.3) 75 (24.4) 114 (25.7) 134 (25.1) 42 (26.1)
Q3 161 (25.9) 33 (21.7) 143 (24.4) 43 (26.9) 137 (24.1) 50 (27.5) 151 (26.0) 43 (22.3) 133 (24.4) 57 (26.1) 77 (25.1) 111 (25.1) 140 (26.2) 41 (25.5)
Q4 147 (23.6) 46 (30.3) 138 (23.6) 49 (30.6) 137 (24.1) 48 (26.4) 130 (22.4) 63 (32.6) 128 (23.5) 65 (29.8) 80 (26.1) 105 (23.7) 131 (24.5) 41 (25.5)
CCL19/MIP3B
Q1 176 (28.5) 16 (10.7) 168 (28.9) 19 (12.0) 163 (28.8) 27 (15.2) 163 (28.2) 29 (15.2) 152 (28.1) 36 (16.7) 94 (30.7) 97 (22.1) 128 (24.2) 38 (23.9)
Q2 155 (25.1) 37 (24.7) 139 (23.9) 46 (29.1) 144 (25.4) 41 (23.0) 152 (26.3) 40 (20.9) 136 (25.1) 53 (24.7) 69 (22.5) 117 (26.7) 134 (25.3) 45 (28.3)
Q3 150 (24.3) 42 (28.0) 137 (23.6) 50 (31.6) 135 (23.9) 47 (26.4) 133 (23.1) 59 (30.9) 128 (23.7) 61 (28.4) 76 (24.8) 105 (24.0) 139 (26.2) 34 (21.4)
Q4 137 (22.2) 55 (36.7) 137 (23.6) 43 (27.2) 124 (21.9) 63 (35.4) 129 (22.4) 63 (33.0) 125 (23.1) 65 (30.2) 67 (21.9) 119 (27.2) 129 (24.3) 42 (26.4)
CCL20/MIP3A
Q1 152 (24.6) 40 (26.7) 150 (25.8) 35 (22.2) 148 (26.1) 40 (22.5) 150 (26.0) 42 (22.0) 127 (23.5) 63 (29.3) 85 (27.8) 103 (23.5) 133 (25.1) 35 (22.0)
Q2 165 (26.7) 27 (18.0) 143 (24.6) 38 (24.1) 141 (24.9) 44 (24.7) 155 (26.9) 37 (19.4) 143 (26.4) 44 (20.5) 74 (24.2) 110 (25.1) 142 (26.8) 37 (23.3)
Q3 160 (25.9) 32 (21.3) 140 (24.1) 48 (30.4) 144 (25.4) 41 (23.0) 142 (24.6) 50 (26.2) 141 (26.1) 47 (21.9) 83 (27.1) 103 (23.5) 127 (24.0) 38 (23.9)
Q4 141 (22.8) 51 (34.0) 148 (25.5) 37 (23.4) 133 (23.5) 53 (29.8) 130 (22.5) 62 (32.5) 130 (24.0) 61 (28.4) 64 (20.9) 122 (27.9) 128 (24.2) 49 (30.8)
CRP
Q1 176 (28.3) 17 (11.3) 152 (26.0) 35 (22.0) 157 (27.7) 30 (16.5) 163 (28.2) 30 (15.5) 159 (29.3) 27 (12.4) 89 (29.0) 98 (22.2) 141 (26.5) 30 (18.8)
Q2 159 (25.6) 34 (22.5) 155 (26.5) 33 (20.8) 141 (24.9) 48 (26.4) 150 (25.9) 43 (22.3) 143 (26.3) 47 (21.7) 75 (24.4) 112 (25.4) 140 (26.3) 35 (21.9)
Q3 148 (23.8) 45 (29.8) 138 (23.6) 47 (29.6) 141 (24.9) 46 (25.3) 145 (25.0) 48 (24.9) 123 (22.7) 70 (32.3) 66 (21.5) 122 (27.7) 133 (25.0) 46 (28.7)
Q4 138 (22.2) 55 (36.4) 140 (23.9) 44 (27.7) 127 (22.4) 58 (31.9) 121 (20.9) 72 (37.3) 118 (21.7) 73 (33.6) 77 (25.1) 109 (24.7) 119 (22.3) 49 (30.6)
CTACK
Q1 152 (24.4) 41 (27.0) 152 (26.0) 32 (20.0) 144 (25.4) 39 (21.4) 136 (23.4) 57 (29.5) 129 (23.7) 61 (28.0) 66 (21.5) 118 (26.6) 133 (24.9) 35 (21.7)
Q2 152 (24.4) 42 (27.6) 148 (25.3) 39 (24.4) 143 (25.2) 47 (25.8) 148 (25.5) 46 (23.8) 145 (26.7) 45 (20.6) 72 (23.5) 117 (26.4) 122 (22.8) 43 (26.7)
Q3 154 (24.8) 40 (26.3) 155 (26.5) 33 (20.6) 138 (24.3) 49 (26.9) 151 (26.0) 43 (22.3) 123 (22.6) 70 (32.1) 82 (26.7) 105 (23.7) 139 (26.0) 40 (24.8)
Q4 164 (26.4) 29 (19.1) 130 (22.2) 56 (35.0) 143 (25.2) 47 (25.8) 146 (25.1) 47 (24.4) 147 (27.0) 42 (19.3) 87 (28.3) 103 (23.3) 140 (26.2) 43 (26.7)
CXCL11/ITAC
Q1 164 (26.5) 28 (18.7) 156 (26.9) 31 (19.6) 145 (25.6) 38 (21.3) 157 (27.2) 35 (18.3) 145 (26.8) 44 (20.5) 74 (24.2) 109 (24.9) 137 (25.8) 32 (20.1)
Q2 155 (25.1) 37 (24.7) 139 (23.9) 48 (30.4) 136 (24.0) 50 (28.1) 142 (24.6) 50 (26.2) 139 (25.7) 51 (23.7) 85 (27.8) 101 (23.1) 133 (25.1) 36 (22.6)
Q3 149 (24.1) 43 (28.7) 144 (24.8) 39 (24.7) 137 (24.2) 50 (28.1) 139 (24.1) 53 (27.7) 128 (23.7) 59 (27.4) 68 (22.2) 119 (27.2) 123 (23.2) 49 (30.8)
Q4 150 (24.3) 42 (28.0) 142 (24.4) 40 (25.3) 148 (26.1) 40 (22.5) 139 (24.1) 53 (27.7) 129 (23.8) 61 (28.4) 79 (25.8) 109 (24.9) 137 (25.8) 42 (26.4)
CXCL6/GCP2
Q1 156 (25.2) 36 (24.0) 149 (25.6) 37 (23.4) 146 (25.8) 42 (23.6) 154 (26.7) 38 (19.9) 141 (26.1) 51 (23.7) 76 (24.8) 112 (25.6) 131 (24.7) 42 (26.4)
Q2 158 (25.6) 34 (22.7) 144 (24.8) 38 (24.1) 141 (24.9) 43 (24.2) 158 (27.4) 34 (17.8) 138 (25.5) 50 (23.3) 67 (21.9) 118 (26.9) 137 (25.8) 39 (24.5)
Q3 160 (25.9) 32 (21.3) 144 (24.8) 41 (25.9) 137 (24.2) 47 (26.4) 137 (23.7) 55 (28.8) 142 (26.2) 46 (21.4) 87 (28.4) 98 (22.4) 134 (25.3) 37 (23.3)
Q4 144 (23.3) 48 (32.0) 144 (24.8) 42 (26.6) 142 (25.1) 46 (25.8) 128 (22.2) 64 (33.5) 120 (22.2) 68 (31.6) 76 (24.8) 110 (25.1) 128 (24.2) 41 (25.8)
CXCL9/MIG
Q1 167 (27.0) 25 (16.7) 156 (26.9) 32 (20.3) 145 (25.6) 38 (21.3) 157 (27.2) 35 (18.3) 143 (26.4) 46 (21.4) 94 (30.7) 90 (20.5) 140 (26.4) 33 (20.8)
Q2 151 (24.4) 41 (27.3) 136 (23.4) 47 (29.7) 140 (24.7) 46 (25.8) 151 (26.2) 41 (21.5) 136 (25.1) 54 (25.1) 69 (22.5) 116 (26.5) 137 (25.8) 37 (23.3)
Q3 153 (24.8) 39 (26.0) 145 (25.0) 41 (25.9) 137 (24.2) 49 (27.5) 142 (24.6) 50 (26.2) 127 (23.5) 62 (28.8) 71 (23.2) 115 (26.3) 121 (22.8) 45 (28.3)
HyperglycemiaMtS Low PA High TG Low HDL Obesity Hypertension
Q4 147 (23.8) 45 (30.0) 144 (24.8) 38 (24.1) 144 (25.4) 45 (25.3) 127 (22.0) 65 (34.0) 135 (25.0) 53 (24.7) 72 (23.5) 117 (26.7) 132 (24.9) 44 (27.7)
EGF
Q1 149 (24.0) 44 (28.9) 150 (25.6) 37 (23.1) 148 (26.1) 37 (20.3) 145 (25.0) 48 (24.9) 125 (23.0) 66 (30.3) 76 (24.8) 109 (24.6) 132 (24.7) 41 (25.5)
Q2 167 (26.8) 27 (17.8) 134 (22.9) 49 (30.6) 159 (28.0) 31 (17.0) 158 (27.2) 36 (18.7) 136 (25.0) 56 (25.7) 85 (27.7) 105 (23.7) 146 (27.3) 32 (19.9)
Q3 150 (24.1) 44 (28.9) 151 (25.8) 40 (25.0) 131 (23.1) 57 (31.3) 141 (24.3) 53 (27.5) 140 (25.7) 51 (23.4) 74 (24.1) 115 (26.0) 130 (24.3) 41 (25.5)
Q4 156 (25.1) 37 (24.3) 150 (25.6) 34 (21.2) 130 (22.9) 57 (31.3) 137 (23.6) 56 (29.0) 143 (26.3) 45 (20.6) 72 (23.5) 114 (25.7) 126 (23.6) 47 (29.2)
ENA78
Q1 159 (25.6) 34 (22.4) 133 (22.7) 48 (30.0) 150 (26.4) 41 (22.5) 156 (26.9) 37 (19.2) 139 (25.6) 51 (23.4) 68 (22.1) 124 (28.0) 137 (25.7) 40 (24.8)
Q2 155 (24.9) 39 (25.7) 140 (23.9) 48 (30.0) 136 (23.9) 46 (25.3) 149 (25.6) 45 (23.3) 137 (25.2) 57 (26.1) 80 (26.1) 102 (23.0) 123 (23.0) 45 (28.0)
Q3 153 (24.6) 41 (27.0) 159 (27.2) 29 (18.1) 143 (25.2) 46 (25.3) 141 (24.3) 53 (27.5) 131 (24.1) 60 (27.5) 85 (27.7) 104 (23.5) 134 (25.1) 36 (22.4)
Q4 155 (24.9) 38 (25.0) 153 (26.2) 35 (21.9) 139 (24.5) 49 (26.9) 135 (23.2) 58 (30.1) 137 (25.2) 50 (22.9) 74 (24.1) 113 (25.5) 140 (26.2) 40 (24.8)
EOTAXIN2
Q1 159 (25.6) 34 (22.4) 151 (25.8) 38 (23.8) 140 (24.6) 49 (26.9) 142 (24.4) 51 (26.4) 137 (25.2) 55 (25.2) 91 (29.6) 100 (22.6) 145 (27.2) 35 (21.7)
Q2 157 (25.2) 37 (24.3) 142 (24.3) 45 (28.1) 144 (25.4) 41 (22.5) 146 (25.1) 48 (24.9) 143 (26.3) 50 (22.9) 80 (26.1) 105 (23.7) 131 (24.5) 44 (27.3)
Q3 156 (25.1) 38 (25.0) 142 (24.3) 44 (27.5) 143 (25.2) 46 (25.3) 140 (24.1) 54 (28.0) 134 (24.6) 55 (25.2) 86 (28.0) 102 (23.0) 126 (23.6) 44 (27.3)
Q4 150 (24.1) 43 (28.3) 150 (25.6) 33 (20.6) 141 (24.8) 46 (25.3) 153 (26.3) 40 (20.7) 130 (23.9) 58 (26.6) 50 (16.3) 136 (30.7) 132 (24.7) 38 (23.6)
EOTAXIN
Q1 150 (24.1) 43 (28.3) 146 (25.0) 40 (25.0) 146 (25.7) 42 (23.1) 138 (23.8) 55 (28.5) 129 (23.7) 63 (28.9) 98 (31.9) 90 (20.3) 146 (27.3) 32 (19.9)
Q2 154 (24.8) 40 (26.3) 143 (24.4) 44 (27.5) 135 (23.8) 52 (28.6) 149 (25.6) 45 (23.3) 134 (24.6) 58 (26.6) 72 (23.5) 116 (26.2) 125 (23.4) 46 (28.6)
Q3 160 (25.7) 34 (22.4) 150 (25.6) 39 (24.4) 142 (25.0) 43 (23.6) 142 (24.4) 52 (26.9) 146 (26.8) 45 (20.6) 72 (23.5) 113 (25.5) 131 (24.5) 37 (23.0)
Q4 158 (25.4) 35 (23.0) 146 (25.0) 37 (23.1) 145 (25.5) 45 (24.7) 152 (26.2) 41 (21.2) 135 (24.8) 52 (23.9) 65 (21.2) 124 (28.0) 132 (24.7) 46 (28.6)
FGF2
Q1 233 (37.5) 55 (36.2) 225 (38.5) 51 (31.9) 213 (37.5) 69 (37.9) 220 (37.9) 68 (35.2) 205 (37.7) 78 (35.8) 115 (37.5) 167 (37.7) 198 (37.1) 58 (36.0)
Q2 125 (20.1) 37 (24.3) 127 (21.7) 31 (19.4) 114 (20.1) 44 (24.2) 118 (20.3) 44 (22.8) 105 (19.3) 54 (24.8) 58 (18.9) 100 (22.6) 108 (20.2) 36 (22.4)
Q3 127 (20.4) 35 (23.0) 124 (21.2) 33 (20.6) 120 (21.1) 36 (19.8) 122 (21.0) 40 (20.7) 111 (20.4) 50 (22.9) 69 (22.5) 87 (19.6) 111 (20.8) 38 (23.6)
Q4 137 (22.0) 25 (16.4) 109 (18.6) 45 (28.1) 121 (21.3) 33 (18.1) 121 (20.8) 41 (21.2) 123 (22.6) 36 (16.5) 65 (21.2) 89 (20.1) 117 (21.9) 29 (18.0)
GRO
Q1 153 (24.6) 40 (26.3) 140 (23.9) 44 (27.5) 142 (25.0) 46 (25.3) 150 (25.8) 43 (22.3) 134 (24.6) 58 (26.6) 73 (23.8) 114 (25.7) 138 (25.8) 41 (25.5)
Q2 150 (24.1) 44 (28.9) 142 (24.3) 42 (26.2) 141 (24.8) 47 (25.8) 155 (26.7) 39 (20.2) 126 (23.2) 66 (30.3) 73 (23.8) 115 (26.0) 132 (24.7) 42 (26.1)
Q3 157 (25.2) 37 (24.3) 152 (26.0) 37 (23.1) 135 (23.8) 52 (28.6) 138 (23.8) 56 (29.0) 141 (25.9) 50 (22.9) 79 (25.7) 109 (24.6) 133 (24.9) 36 (22.4)
Q4 162 (26.0) 31 (20.4) 151 (25.8) 37 (23.1) 150 (26.4) 37 (20.3) 138 (23.8) 55 (28.5) 143 (26.3) 44 (20.2) 82 (26.7) 105 (23.7) 131 (24.5) 42 (26.1)
GCSF
Q1 160 (25.7) 33 (21.7) 141 (24.1) 44 (27.5) 151 (26.6) 39 (21.4) 154 (26.5) 39 (20.2) 131 (24.1) 59 (27.1) 73 (23.8) 115 (26.0) 130 (24.3) 41 (25.5)
Q2 144 (23.2) 50 (32.9) 155 (26.5) 31 (19.4) 129 (22.7) 56 (30.8) 128 (22.0) 66 (34.2) 131 (24.1) 58 (26.6) 68 (22.1) 119 (26.9) 126 (23.6) 46 (28.6)
Q3 157 (25.2) 37 (24.3) 145 (24.8) 39 (24.4) 148 (26.1) 44 (24.2) 155 (26.7) 39 (20.2) 137 (25.2) 55 (25.2) 88 (28.7) 104 (23.5) 142 (26.6) 36 (22.4)
Q4 161 (25.9) 32 (21.1) 144 (24.6) 46 (28.7) 140 (24.6) 43 (23.6) 144 (24.8) 49 (25.4) 145 (26.7) 46 (21.1) 78 (25.4) 105 (23.7) 136 (25.5) 38 (23.6)
IL16
Q1 155 (24.9) 38 (25.0) 150 (25.6) 32 (20.0) 149 (26.2) 40 (22.0) 142 (24.4) 51 (26.4) 123 (22.6) 62 (28.4) 82 (26.7) 108 (24.4) 135 (25.3) 38 (23.6)
Q2 163 (26.2) 31 (20.4) 151 (25.8) 36 (22.5) 156 (27.5) 31 (17.0) 155 (26.7) 39 (20.2) 142 (26.1) 50 (22.9) 70 (22.8) 117 (26.4) 134 (25.1) 35 (21.7)
Q3 151 (24.3) 43 (28.3) 144 (24.6) 45 (28.1) 133 (23.4) 54 (29.7) 136 (23.4) 58 (30.1) 137 (25.2) 56 (25.7) 78 (25.4) 108 (24.4) 131 (24.5) 44 (27.3)
Q4 153 (24.6) 40 (26.3) 140 (23.9) 47 (29.4) 130 (22.9) 57 (31.3) 148 (25.5) 45 (23.3) 142 (26.1) 50 (22.9) 77 (25.1) 110 (24.8) 134 (25.1) 44 (27.3)
IL1RA
Q1 191 (30.7) 56 (36.8) 191 (32.6) 46 (28.7) 171 (30.1) 69 (37.9) 178 (30.6) 69 (35.8) 173 (31.8) 68 (31.2) 92 (30.0) 147 (33.2) 174 (32.6) 44 (27.3)
Q2 143 (23.0) 31 (20.4) 128 (21.9) 41 (25.6) 133 (23.4) 38 (20.9) 134 (23.1) 40 (20.7) 122 (22.4) 49 (22.5) 63 (20.5) 109 (24.6) 117 (21.9) 42 (26.1)
Q3 142 (22.8) 35 (23.0) 142 (24.3) 28 (17.5) 131 (23.1) 41 (22.5) 138 (23.8) 39 (20.2) 124 (22.8) 52 (23.9) 74 (24.1) 98 (22.1) 116 (21.7) 45 (28.0)
Q4 146 (23.5) 30 (19.7) 124 (21.2) 45 (28.1) 133 (23.4) 34 (18.7) 131 (22.5) 45 (23.3) 125 (23.0) 49 (22.5) 78 (25.4) 89 (20.1) 127 (23.8) 30 (18.6)
IL29IFNL1
Q1 494 (79.9) 110 (73.3) 456 (78.5) 127 (80.4) 447 (79.0) 139 (78.1) 457 (79.2) 147 (77.0) 427 (78.9) 167 (77.7) 249 (81.4) 337 (76.9) 413 (77.9) 123 (77.4)
Q2 124 (20.1) 40 (26.7) 125 (21.5) 31 (19.6) 119 (21.0) 39 (21.9) 120 (20.8) 44 (23.0) 114 (21.1) 48 (22.3) 57 (18.6) 101 (23.1) 117 (22.1) 36 (22.6)
IL33
Q1 494 (79.4) 121 (79.6) 472 (80.7) 121 (75.6) 452 (79.6) 144 (79.1) 468 (80.6) 147 (76.2) 431 (79.2) 174 (79.8) 241 (78.5) 354 (79.9) 417 (78.1) 129 (80.1)
Q2 128 (20.6) 31 (20.4) 113 (19.3) 39 (24.4) 116 (20.4) 38 (20.9) 113 (19.4) 46 (23.8) 113 (20.8) 44 (20.2) 66 (21.5) 89 (20.1) 117 (21.9) 32 (19.9)
IL8
Q1 151 (24.3) 42 (27.6) 133 (22.7) 53 (33.1) 132 (23.2) 54 (29.7) 140 (24.1) 53 (27.5) 135 (24.8) 56 (25.7) 79 (25.7) 106 (23.9) 139 (26.0) 44 (27.3)
Q2 156 (25.1) 38 (25.0) 142 (24.3) 44 (27.5) 144 (25.4) 44 (24.2) 152 (26.2) 42 (21.8) 140 (25.7) 50 (22.9) 86 (28.0) 102 (23.0) 136 (25.5) 37 (23.0)
Q3 160 (25.7) 34 (22.4) 156 (26.7) 29 (18.1) 144 (25.4) 46 (25.3) 152 (26.2) 42 (21.8) 139 (25.6) 53 (24.3) 67 (21.8) 123 (27.8) 132 (24.7) 38 (23.6)
Q4 155 (24.9) 38 (25.0) 154 (26.3) 34 (21.2) 148 (26.1) 38 (20.9) 137 (23.6) 56 (29.0) 130 (23.9) 59 (27.1) 75 (24.4) 112 (25.3) 127 (23.8) 42 (26.1)
IP10
Q1 155 (24.9) 38 (25.0) 147 (25.1) 38 (23.8) 142 (25.0) 43 (23.6) 148 (25.5) 45 (23.3) 147 (27.0) 45 (20.6) 70 (22.8) 116 (26.2) 133 (24.9) 36 (22.4)
Q2 165 (26.5) 29 (19.1) 150 (25.6) 39 (24.4) 141 (24.8) 44 (24.2) 153 (26.3) 41 (21.2) 138 (25.4) 53 (24.3) 78 (25.4) 107 (24.2) 141 (26.4) 29 (18.0)
Q3 156 (25.1) 38 (25.0) 149 (25.5) 39 (24.4) 146 (25.7) 44 (24.2) 150 (25.8) 44 (22.8) 136 (25.0) 54 (24.8) 75 (24.4) 115 (26.0) 132 (24.7) 47 (29.2)
Q4 146 (23.5) 47 (30.9) 139 (23.8) 44 (27.5) 139 (24.5) 51 (28.0) 130 (22.4) 63 (32.6) 123 (22.6) 66 (30.3) 84 (27.4) 105 (23.7) 128 (24.0) 49 (30.4)
MCP1
Q1 163 (26.2) 30 (19.7) 161 (27.5) 29 (18.1) 155 (27.3) 34 (18.7) 149 (25.6) 44 (22.8) 142 (26.1) 51 (23.4) 85 (27.7) 105 (23.7) 134 (25.1) 35 (21.7)
Q2 163 (26.2) 31 (20.4) 152 (26.0) 34 (21.2) 158 (27.8) 34 (18.7) 160 (27.5) 34 (17.6) 139 (25.6) 51 (23.4) 88 (28.7) 104 (23.5) 129 (24.2) 43 (26.7)
Q3 149 (24.0) 45 (29.6) 134 (22.9) 50 (31.2) 123 (21.7) 59 (32.4) 139 (23.9) 55 (28.5) 139 (25.6) 52 (23.9) 68 (22.1) 115 (26.0) 138 (25.8) 36 (22.4)
Q4 147 (23.6) 46 (30.3) 138 (23.6) 47 (29.4) 132 (23.2) 55 (30.2) 133 (22.9) 60 (31.1) 124 (22.8) 64 (29.4) 66 (21.5) 119 (26.9) 133 (24.9) 47 (29.2)
MCP2
Q1 161 (25.9) 32 (21.1) 148 (25.3) 36 (22.5) 139 (24.5) 50 (27.5) 150 (25.8) 43 (22.3) 138 (25.4) 52 (23.9) 81 (26.4) 107 (24.2) 133 (24.9) 34 (21.1)
Q2 157 (25.2) 37 (24.3) 148 (25.3) 42 (26.2) 147 (25.9) 42 (23.1) 147 (25.3) 47 (24.4) 138 (25.4) 52 (23.9) 86 (28.0) 103 (23.3) 136 (25.5) 40 (24.8)
Q3 142 (22.8) 52 (34.2) 141 (24.1) 43 (26.9) 132 (23.2) 55 (30.2) 136 (23.4) 58 (30.1) 133 (24.4) 60 (27.5) 71 (23.1) 116 (26.2) 129 (24.2) 47 (29.2)
Q4 162 (26.0) 31 (20.4) 148 (25.3) 39 (24.4) 150 (26.4) 35 (19.2) 148 (25.5) 45 (23.3) 135 (24.8) 54 (24.8) 69 (22.5) 117 (26.4) 136 (25.5) 40 (24.8)
MCP4
Q1 290 (46.6) 59 (38.8) 266 (45.5) 68 (42.5) 260 (45.8) 77 (42.3) 268 (46.1) 81 (42.0) 241 (44.3) 100 (45.9) 149 (48.5) 188 (42.4) 240 (44.9) 68 (42.2)
Q2 112 (18.0) 28 (18.4) 112 (19.1) 24 (15.0) 102 (18.0) 31 (17.0) 106 (18.2) 34 (17.6) 98 (18.0) 42 (19.3) 50 (16.3) 84 (19.0) 89 (16.7) 35 (21.7)
Q3 105 (16.9) 37 (24.3) 111 (19.0) 25 (15.6) 100 (17.6) 41 (22.5) 101 (17.4) 41 (21.2) 100 (18.4) 41 (18.8) 54 (17.6) 86 (19.4) 99 (18.5) 31 (19.3)
Q4 115 (18.5) 28 (18.4) 96 (16.4) 43 (26.9) 106 (18.7) 33 (18.1) 106 (18.2) 37 (19.2) 105 (19.3) 35 (16.1) 54 (17.6) 85 (19.2) 106 (19.9) 27 (16.8)
MDC
Q1 153 (24.6) 40 (26.3) 147 (25.1) 40 (25.0) 148 (26.1) 41 (22.5) 146 (25.1) 47 (24.4) 129 (23.7) 60 (27.5) 74 (24.1) 116 (26.2) 133 (24.9) 42 (26.1)
Q2 158 (25.4) 36 (23.7) 145 (24.8) 40 (25.0) 136 (23.9) 51 (28.0) 149 (25.6) 45 (23.3) 146 (26.8) 45 (20.6) 81 (26.4) 105 (23.7) 134 (25.1) 40 (24.8)
Q3 158 (25.4) 36 (23.7) 147 (25.1) 40 (25.0) 141 (24.8) 46 (25.3) 151 (26.0) 43 (22.3) 133 (24.4) 59 (27.1) 77 (25.1) 110 (24.8) 134 (25.1) 36 (22.4)
Q4 153 (24.6) 40 (26.3) 146 (25.0) 40 (25.0) 143 (25.2) 44 (24.2) 135 (23.2) 58 (30.1) 136 (25.0) 54 (24.8) 75 (24.4) 112 (25.3) 133 (24.9) 43 (26.7)
MIP1B
Q1 162 (26.0) 31 (20.4) 141 (24.1) 44 (27.5) 145 (25.5) 43 (23.6) 153 (26.3) 40 (20.7) 144 (26.5) 47 (21.6) 81 (26.4) 107 (24.2) 141 (26.4) 37 (23.0)
Q2 152 (24.4) 42 (27.6) 149 (25.5) 39 (24.4) 139 (24.5) 50 (27.5) 142 (24.4) 52 (26.9) 139 (25.6) 52 (23.9) 78 (25.4) 112 (25.3) 134 (25.1) 42 (26.1)
Q3 149 (24.0) 45 (29.6) 147 (25.1) 40 (25.0) 140 (24.6) 47 (25.8) 143 (24.6) 51 (26.4) 133 (24.4) 58 (26.6) 71 (23.1) 115 (26.0) 128 (24.0) 41 (25.5)
Q4 159 (25.6) 34 (22.4) 148 (25.3) 37 (23.1) 144 (25.4) 42 (23.1) 143 (24.6) 50 (25.9) 128 (23.5) 61 (28.0) 77 (25.1) 109 (24.6) 131 (24.5) 41 (25.5)
MIP1D
Q1 155 (24.9) 38 (25.0) 145 (24.8) 38 (23.8) 150 (26.4) 37 (20.3) 147 (25.3) 46 (23.8) 139 (25.6) 53 (24.3) 90 (29.3) 97 (21.9) 137 (25.7) 38 (23.6)
Q2 161 (25.9) 33 (21.7) 154 (26.3) 34 (21.2) 148 (26.1) 43 (23.6) 154 (26.5) 40 (20.7) 137 (25.2) 52 (23.9) 67 (21.8) 124 (28.0) 135 (25.3) 41 (25.5)
Q3 156 (25.1) 38 (25.0) 144 (24.6) 45 (28.1) 134 (23.6) 53 (29.1) 141 (24.3) 53 (27.5) 132 (24.3) 59 (27.1) 83 (27.0) 103 (23.3) 130 (24.3) 39 (24.2)
Q4 150 (24.1) 43 (28.3) 142 (24.3) 43 (26.9) 136 (23.9) 49 (26.9) 139 (23.9) 54 (28.0) 136 (25.0) 54 (24.8) 67 (21.8) 119 (26.9) 132 (24.7) 43 (26.7)
SAA
Q1 173 (27.9) 20 (13.2) 155 (26.5) 32 (20.1) 160 (28.3) 29 (15.9) 159 (27.5) 34 (17.6) 152 (28.0) 38 (17.5) 82 (26.7) 108 (24.5) 144 (27.0) 29 (18.1)
Q2 151 (24.3) 42 (27.8) 147 (25.1) 41 (25.8) 132 (23.3) 53 (29.1) 142 (24.5) 51 (26.4) 138 (25.4) 52 (24.0) 78 (25.4) 106 (24.0) 132 (24.8) 39 (24.4)
Q3 147 (23.7) 46 (30.5) 138 (23.6) 46 (28.9) 140 (24.7) 47 (25.8) 133 (23.0) 60 (31.1) 133 (24.5) 55 (25.3) 79 (25.7) 107 (24.3) 129 (24.2) 45 (28.1)
Q4 150 (24.2) 43 (28.5) 145 (24.8) 40 (25.2) 134 (23.7) 53 (29.1) 145 (25.0) 48 (24.9) 120 (22.1) 72 (33.2) 68 (22.1) 120 (27.2) 128 (24.0) 47 (29.4)
SAP
Q1 167 (26.9) 26 (17.2) 155 (26.5) 30 (18.9) 160 (28.3) 26 (14.3) 139 (24.0) 54 (28.0) 144 (26.5) 45 (20.7) 90 (29.3) 96 (21.8) 142 (26.6) 29 (18.1)
Q2 156 (25.1) 37 (24.5) 144 (24.6) 39 (24.5) 140 (24.7) 50 (27.5) 149 (25.7) 44 (22.8) 140 (25.8) 50 (23.0) 76 (24.8) 114 (25.9) 137 (25.7) 40 (25.0)
Q3 152 (24.5) 41 (27.2) 149 (25.5) 37 (23.3) 143 (25.3) 44 (24.2) 142 (24.5) 51 (26.4) 119 (21.9) 71 (32.7) 76 (24.8) 112 (25.4) 137 (25.7) 33 (20.6)
Q4 146 (23.5) 47 (31.1) 137 (23.4) 53 (33.3) 123 (21.7) 62 (34.1) 149 (25.7) 44 (22.8) 140 (25.8) 51 (23.5) 65 (21.2) 119 (27.0) 117 (22.0) 58 (36.2)
SCF
Q1 160 (25.7) 33 (21.7) 151 (25.8) 33 (20.6) 150 (26.4) 39 (21.4) 153 (26.3) 40 (20.7) 132 (24.3) 56 (25.7) 86 (28.0) 102 (23.0) 132 (24.7) 45 (28.0)
Q2 161 (25.9) 33 (21.7) 148 (25.3) 38 (23.8) 150 (26.4) 36 (19.8) 150 (25.8) 44 (22.8) 148 (27.2) 45 (20.6) 80 (26.1) 107 (24.2) 136 (25.5) 39 (24.2)
Q3 160 (25.7) 34 (22.4) 155 (26.5) 33 (20.6) 142 (25.0) 47 (25.8) 152 (26.2) 42 (21.8) 134 (24.6) 58 (26.6) 78 (25.4) 111 (25.1) 133 (24.9) 42 (26.1)
Q4 141 (22.7) 52 (34.2) 131 (22.4) 56 (35.0) 126 (22.2) 60 (33.0) 126 (21.7) 67 (34.7) 130 (23.9) 59 (27.1) 63 (20.5) 123 (27.8) 133 (24.9) 35 (21.7)
SDF1AB
Q1 136 (21.9) 57 (37.5) 153 (26.2) 30 (18.8) 117 (20.6) 70 (38.5) 123 (21.2) 70 (36.3) 133 (24.4) 59 (27.1) 74 (24.1) 113 (25.5) 133 (24.9) 41 (25.5)
Q2 151 (24.3) 43 (28.3) 142 (24.3) 46 (28.7) 136 (23.9) 51 (28.0) 147 (25.3) 47 (24.4) 123 (22.6) 67 (30.7) 74 (24.1) 113 (25.5) 131 (24.5) 46 (28.6)
Q3 161 (25.9) 33 (21.7) 157 (26.8) 32 (20.0) 151 (26.6) 37 (20.3) 151 (26.0) 43 (22.3) 135 (24.8) 54 (24.8) 82 (26.7) 107 (24.2) 122 (22.8) 46 (28.6)
Q4 174 (28.0) 19 (12.5) 133 (22.7) 52 (32.5) 164 (28.9) 24 (13.2) 160 (27.5) 33 (17.1) 153 (28.1) 38 (17.4) 77 (25.1) 110 (24.8) 148 (27.7) 28 (17.4)
SEGFR
Q1 133 (25.3) 31 (23.8) 121 (24.8) 35 (24.8) 132 (27.3) 30 (19.5) 117 (23.8) 47 (28.7) 116 (25.2) 47 (25.5) 73 (28.6) 90 (23.6) 129 (28.1) 24 (18.0)
Q2 129 (24.5) 35 (26.9) 124 (25.4) 35 (24.8) 111 (23.0) 48 (31.2) 120 (24.4) 44 (26.8) 115 (24.9) 45 (24.5) 50 (19.6) 108 (28.3) 111 (24.2) 32 (24.1)
Q3 131 (24.9) 33 (25.4) 120 (24.6) 35 (24.8) 116 (24.0) 43 (27.9) 129 (26.2) 35 (21.3) 116 (25.2) 46 (25.0) 67 (26.3) 92 (24.1) 107 (23.3) 40 (30.1)
Q4 133 (25.3) 31 (23.8) 123 (25.2) 36 (25.5) 124 (25.7) 33 (21.4) 126 (25.6) 38 (23.2) 114 (24.7) 46 (25.0) 65 (25.5) 92 (24.1) 112 (24.4) 37 (27.8)
SGP130
Q1 138 (26.2) 26 (20.0) 133 (27.3) 25 (17.7) 129 (26.7) 33 (21.4) 125 (25.4) 39 (23.8) 114 (24.7) 49 (26.6) 79 (31.0) 83 (21.7) 124 (27.0) 31 (23.3)
Q2 129 (24.5) 35 (26.9) 127 (26.0) 31 (22.0) 120 (24.8) 40 (26.0) 121 (24.6) 43 (26.2) 122 (26.5) 38 (20.7) 58 (22.7) 103 (27.0) 117 (25.5) 27 (20.3)
Q3 134 (25.5) 30 (23.1) 115 (23.6) 43 (30.5) 118 (24.4) 40 (26.0) 126 (25.6) 38 (23.2) 114 (24.7) 47 (25.5) 59 (23.1) 99 (25.9) 110 (24.0) 34 (25.6)
Q4 125 (23.8) 39 (30.0) 113 (23.2) 42 (29.8) 116 (24.0) 41 (26.6) 120 (24.4) 44 (26.8) 111 (24.1) 50 (27.2) 59 (23.1) 97 (25.4) 108 (23.5) 41 (30.8)
SILRII
Q1 130 (24.7) 35 (26.9) 119 (24.4) 35 (24.8) 123 (25.5) 37 (24.0) 115 (23.4) 50 (30.5) 121 (26.2) 40 (21.7) 66 (25.9) 94 (24.6) 127 (27.7) 24 (18.0)
Q2 135 (25.7) 28 (21.5) 121 (24.8) 34 (24.1) 120 (24.8) 35 (22.7) 122 (24.8) 41 (25.0) 116 (25.2) 45 (24.5) 69 (27.1) 87 (22.8) 116 (25.3) 28 (21.1)
Q3 133 (25.3) 31 (23.8) 125 (25.6) 34 (24.1) 127 (26.3) 34 (22.1) 121 (24.6) 43 (26.2) 113 (24.5) 48 (26.1) 58 (22.7) 103 (27.0) 115 (25.1) 33 (24.8)
Q4 128 (24.3) 36 (27.7) 123 (25.2) 38 (27.0) 113 (23.4) 48 (31.2) 134 (27.2) 30 (18.3) 111 (24.1) 51 (27.7) 62 (24.3) 98 (25.7) 101 (22.0) 48 (36.1)
SIL4R
Q1 130 (24.7) 34 (26.2) 125 (25.6) 31 (22.0) 122 (25.3) 36 (23.4) 124 (25.2) 40 (24.4) 112 (24.3) 49 (26.6) 56 (22.0) 103 (27.0) 111 (24.2) 37 (27.8)
Q2 133 (25.3) 31 (23.8) 121 (24.8) 33 (23.4) 116 (24.0) 42 (27.3) 130 (26.4) 34 (20.7) 119 (25.8) 40 (21.7) 62 (24.3) 95 (24.9) 115 (25.1) 32 (24.1)
Q3 133 (25.3) 32 (24.6) 119 (24.4) 39 (27.7) 121 (25.1) 40 (26.0) 120 (24.4) 45 (27.4) 115 (24.9) 48 (26.1) 75 (29.4) 86 (22.5) 109 (23.7) 36 (27.1)
Q4 130 (24.7) 33 (25.4) 123 (25.2) 38 (27.0) 124 (25.7) 36 (23.4) 118 (24.0) 45 (27.4) 115 (24.9) 47 (25.5) 62 (24.3) 98 (25.7) 124 (27.0) 28 (21.1)
SIL6R
Q1 139 (26.4) 25 (19.2) 130 (26.6) 29 (20.6) 134 (27.7) 26 (16.9) 132 (26.8) 32 (19.5) 115 (24.9) 47 (25.5) 66 (25.9) 94 (24.6) 119 (25.9) 32 (24.1)
Q2 130 (24.7) 34 (26.2) 131 (26.8) 24 (17.0) 123 (25.5) 38 (24.7) 122 (24.8) 42 (25.6) 114 (24.7) 49 (26.6) 60 (23.5) 101 (26.4) 111 (24.2) 34 (25.6)
Q3 128 (24.3) 36 (27.7) 121 (24.8) 36 (25.5) 119 (24.6) 39 (25.3) 121 (24.6) 43 (26.2) 113 (24.5) 48 (26.1) 66 (25.9) 92 (24.1) 118 (25.7) 36 (27.1)
Q4 129 (24.5) 35 (26.9) 106 (21.7) 52 (36.9) 107 (22.2) 51 (33.1) 117 (23.8) 47 (28.7) 119 (25.8) 40 (21.7) 63 (24.7) 95 (24.9) 111 (24.2) 31 (23.3)
STNFRII
Q1 139 (26.4) 25 (19.2) 131 (26.8) 30 (21.3) 128 (26.5) 31 (20.1) 133 (27.0) 31 (18.9) 120 (26.0) 42 (22.8) 67 (26.3) 92 (24.1) 116 (25.3) 36 (27.1)
Q2 132 (25.1) 32 (24.6) 127 (26.0) 30 (21.3) 122 (25.3) 40 (26.0) 131 (26.6) 33 (20.1) 112 (24.3) 51 (27.7) 69 (27.1) 93 (24.3) 114 (24.8) 31 (23.3)
Q3 126 (24.0) 38 (29.2) 114 (23.4) 40 (28.4) 113 (23.4) 44 (28.6) 121 (24.6) 43 (26.2) 115 (24.9) 44 (23.9) 55 (21.6) 102 (26.7) 112 (24.4) 36 (27.1)
Q4 129 (24.5) 35 (26.9) 116 (23.8) 41 (29.1) 120 (24.8) 39 (25.3) 107 (21.7) 57 (34.8) 114 (24.7) 47 (25.5) 64 (25.1) 95 (24.9) 117 (25.5) 30 (22.6)
STNFRI
Q1 138 (26.2) 26 (20.0) 125 (25.6) 32 (22.7) 132 (27.3) 25 (16.2) 128 (26.0) 36 (22.0) 121 (26.2) 40 (21.7) 65 (25.5) 92 (24.1) 117 (25.5) 30 (22.6)
Q2 128 (24.3) 36 (27.7) 126 (25.8) 27 (19.1) 118 (24.4) 42 (27.3) 124 (25.2) 40 (24.4) 116 (25.2) 44 (23.9) 57 (22.4) 104 (27.2) 104 (22.7) 41 (30.8)
Q3 129 (24.5) 35 (26.9) 120 (24.6) 40 (28.4) 119 (24.6) 40 (26.0) 119 (24.2) 45 (27.4) 114 (24.7) 50 (27.2) 62 (24.3) 96 (25.1) 117 (25.5) 32 (24.1)
Q4 131 (24.9) 33 (25.4) 117 (24.0) 42 (29.8) 114 (23.6) 47 (30.5) 121 (24.6) 43 (26.2) 110 (23.9) 50 (27.2) 71 (27.8) 90 (23.6) 121 (26.4) 30 (22.6)
SVEGFR2
Q1 132 (25.1) 33 (25.4) 126 (25.8) 32 (22.7) 132 (27.3) 29 (18.8) 118 (24.0) 47 (28.7) 114 (24.7) 49 (26.6) 62 (24.3) 100 (26.2) 124 (27.0) 29 (21.8)
Q2 132 (25.1) 32 (24.6) 125 (25.6) 31 (22.0) 121 (25.1) 41 (26.6) 129 (26.2) 35 (21.3) 123 (26.7) 38 (20.7) 63 (24.7) 99 (25.9) 112 (24.4) 38 (28.6)
Q3 133 (25.3) 31 (23.8) 123 (25.2) 36 (25.5) 115 (23.8) 44 (28.6) 124 (25.2) 40 (24.4) 117 (25.4) 44 (23.9) 57 (22.4) 101 (26.4) 111 (24.2) 31 (23.3)
Q4 129 (24.5) 34 (26.2) 114 (23.4) 42 (29.8) 115 (23.8) 40 (26.0) 121 (24.6) 42 (25.6) 107 (23.2) 53 (28.8) 73 (28.6) 82 (21.5) 112 (24.4) 35 (26.3)
SVEGFR3
Q1 134 (25.5) 31 (23.8) 129 (26.4) 28 (19.9) 133 (27.5) 30 (19.5) 134 (27.2) 31 (18.9) 115 (24.9) 49 (26.6) 68 (26.7) 95 (24.9) 115 (25.1) 38 (28.6)
Q2 136 (25.9) 27 (20.8) 122 (25.0) 36 (25.5) 132 (27.3) 26 (16.9) 122 (24.8) 41 (25.0) 117 (25.4) 42 (22.8) 67 (26.3) 91 (23.8) 116 (25.3) 30 (22.6)
Q3 134 (25.5) 30 (23.1) 121 (24.8) 36 (25.5) 113 (23.4) 46 (29.9) 124 (25.2) 40 (24.4) 121 (26.2) 41 (22.3) 52 (20.4) 107 (28.0) 120 (26.1) 25 (18.8)
Q4 122 (23.2) 42 (32.3) 116 (23.8) 41 (29.1) 105 (21.7) 52 (33.8) 112 (22.8) 52 (31.7) 108 (23.4) 52 (28.3) 68 (26.7) 89 (23.3) 108 (23.5) 40 (30.1)
TARC
Q1 152 (24.4) 41 (27.0) 148 (25.3) 38 (23.8) 136 (23.9) 49 (26.9) 137 (23.6) 56 (29.0) 130 (23.9) 61 (28.0) 74 (24.1) 112 (25.3) 130 (24.3) 40 (24.8)
Q2 144 (23.2) 50 (32.9) 140 (23.9) 44 (27.5) 127 (22.4) 59 (32.4) 144 (24.8) 50 (25.9) 137 (25.2) 56 (25.7) 72 (23.5) 114 (25.7) 124 (23.2) 47 (29.2)
Q3 155 (24.9) 39 (25.7) 149 (25.5) 36 (22.5) 141 (24.8) 49 (26.9) 145 (25.0) 49 (25.4) 136 (25.0) 55 (25.2) 73 (23.8) 117 (26.4) 139 (26.0) 41 (25.5)
Q4 171 (27.5) 22 (14.5) 148 (25.3) 42 (26.2) 164 (28.9) 25 (13.7) 155 (26.7) 38 (19.7) 141 (25.9) 46 (21.1) 88 (28.7) 100 (22.6) 141 (26.4) 33 (20.5)
TGFA
Q1 152 (24.4) 41 (27.0) 152 (26.0) 37 (23.1) 143 (25.2) 45 (24.7) 142 (24.4) 51 (26.4) 140 (25.7) 50 (22.9) 73 (23.8) 116 (26.2) 137 (25.7) 45 (28.0)
Q2 150 (24.1) 44 (28.9) 132 (22.6) 51 (31.9) 136 (23.9) 50 (27.5) 146 (25.1) 48 (24.9) 125 (23.0) 66 (30.3) 72 (23.5) 113 (25.5) 132 (24.7) 38 (23.6)
Q3 164 (26.4) 32 (21.1) 152 (26.0) 36 (22.5) 148 (26.1) 45 (24.7) 158 (27.2) 38 (19.7) 147 (27.0) 47 (21.6) 84 (27.4) 109 (24.6) 135 (25.3) 36 (22.4)
Q4 156 (25.1) 35 (23.0) 149 (25.5) 36 (22.5) 141 (24.8) 42 (23.1) 135 (23.2) 56 (29.0) 132 (24.3) 55 (25.2) 78 (25.4) 105 (23.7) 130 (24.3) 42 (26.1)
TNFA
Q1 165 (26.5) 28 (18.4) 153 (26.2) 38 (23.8) 144 (25.4) 41 (22.5) 151 (26.0) 42 (21.8) 153 (28.1) 40 (18.3) 87 (28.3) 99 (22.3) 141 (26.4) 37 (23.0)
Q2 157 (25.2) 37 (24.3) 141 (24.1) 40 (25.0) 141 (24.8) 48 (26.4) 146 (25.1) 48 (24.9) 136 (25.0) 54 (24.8) 73 (23.8) 115 (26.0) 136 (25.5) 37 (23.0)
Q3 148 (23.8) 46 (30.3) 141 (24.1) 43 (26.9) 137 (24.1) 52 (28.6) 147 (25.3) 47 (24.4) 135 (24.8) 57 (26.1) 76 (24.8) 113 (25.5) 129 (24.2) 45 (28.0)
Q4 152 (24.4) 41 (27.0) 150 (25.6) 39 (24.4) 146 (25.7) 41 (22.5) 137 (23.6) 56 (29.0) 120 (22.1) 67 (30.7) 71 (23.1) 116 (26.2) 128 (24.0) 42 (26.1)
TPO
Q1 155 (24.9) 38 (25.0) 155 (26.5) 32 (20.0) 142 (25.0) 45 (24.7) 151 (26.0) 42 (21.8) 125 (23.0) 67 (30.7) 74 (24.1) 112 (25.3) 122 (22.8) 52 (32.3)
Q2 161 (25.9) 33 (21.7) 141 (24.1) 45 (28.1) 151 (26.6) 41 (22.5) 153 (26.3) 41 (21.2) 139 (25.6) 49 (22.5) 90 (29.3) 103 (23.3) 136 (25.5) 41 (25.5)
Q3 150 (24.1) 45 (29.6) 149 (25.5) 37 (23.1) 134 (23.6) 53 (29.1) 143 (24.6) 52 (26.9) 137 (25.2) 55 (25.2) 72 (23.5) 115 (26.0) 130 (24.3) 36 (22.4)
Q4 156 (25.1) 36 (23.7) 140 (23.9) 46 (28.7) 141 (24.8) 43 (23.6) 134 (23.1) 58 (30.1) 143 (26.3) 47 (21.6) 71 (23.1) 113 (25.5) 146 (27.3) 32 (19.9)
TRAIL
Q1 167 (26.8) 26 (17.1) 142 (24.3) 40 (25.0) 158 (27.8) 30 (16.5) 147 (25.3) 46 (23.8) 151 (27.8) 38 (17.4) 79 (25.7) 111 (25.1) 133 (24.9) 37 (23.0)
Q2 157 (25.2) 37 (24.3) 155 (26.5) 32 (20.0) 143 (25.2) 46 (25.3) 150 (25.8) 44 (22.8) 143 (26.3) 49 (22.5) 79 (25.7) 109 (24.6) 135 (25.3) 42 (26.1)
Q3 155 (24.9) 39 (25.7) 142 (24.3) 45 (28.1) 140 (24.6) 49 (26.9) 149 (25.6) 45 (23.3) 137 (25.2) 54 (24.8) 81 (26.4) 108 (24.4) 131 (24.5) 43 (26.7)
Q4 143 (23.0) 50 (32.9) 146 (25.0) 43 (26.9) 127 (22.4) 57 (31.3) 135 (23.2) 58 (30.1) 113 (20.8) 77 (35.3) 68 (22.1) 115 (26.0) 135 (25.3) 39 (24.2)
TSLP
Q1 539 (86.7) 132 (86.8) 507 (86.7) 140 (87.5) 495 (87.1) 154 (84.6) 504 (86.7) 167 (86.5) 476 (87.5) 184 (84.4) 263 (85.7) 387 (87.4) 462 (86.5) 137 (85.1)
Q2 83 (13.3) 20 (13.2) 78 (13.3) 20 (12.5) 73 (12.9) 28 (15.4) 77 (13.3) 26 (13.5) 68 (12.5) 34 (15.6) 44 (14.3) 56 (12.6) 72 (13.5) 24 (14.9)
VEGF
Q1 232 (37.3) 49 (32.2) 212 (36.2) 61 (38.1) 209 (36.8) 65 (35.7) 219 (37.7) 62 (32.1) 197 (36.2) 77 (35.3) 109 (35.5) 164 (37.0) 190 (35.6) 57 (35.4)
Q2 128 (20.6) 36 (23.7) 126 (21.5) 30 (18.8) 117 (20.6) 44 (24.2) 116 (20.0) 48 (24.9) 115 (21.1) 47 (21.6) 72 (23.5) 89 (20.1) 113 (21.2) 35 (21.7)
Q3 129 (20.7) 36 (23.7) 130 (22.2) 30 (18.8) 119 (21.0) 40 (22.0) 125 (21.5) 40 (20.7) 111 (20.4) 54 (24.8) 65 (21.2) 94 (21.2) 115 (21.5) 38 (23.6)
Q4 133 (21.4) 31 (20.4) 117 (20.0) 39 (24.4) 123 (21.7) 33 (18.1) 121 (20.8) 43 (22.3) 121 (22.2) 40 (18.3) 61 (19.9) 96 (21.7) 116 (21.7) 31 (19.3)
FRACTALKINE
Q1 131 (24.8) 32 (25.6) 123 (24.9) 34 (25.0) 118 (24.3) 42 (28.4) 130 (26.3) 33 (20.6) 115 (25.3) 46 (24.2) 54 (20.4) 106 (28.7) 109 (24.3) 37 (27.0)
Q2 130 (24.6) 34 (27.2) 113 (22.9) 44 (32.4) 118 (24.3) 41 (27.7) 125 (25.3) 39 (24.4) 121 (26.6) 41 (21.6) 64 (24.2) 95 (25.7) 104 (23.2) 39 (28.5)
Q3 145 (27.4) 19 (15.2) 132 (26.8) 28 (20.6) 128 (26.3) 28 (18.9) 128 (25.9) 36 (22.5) 112 (24.6) 49 (25.8) 73 (27.5) 83 (22.5) 125 (27.8) 25 (18.2)
Q4 123 (23.3) 40 (32.0) 125 (25.4) 30 (22.1) 122 (25.1) 37 (25.0) 111 (22.5) 52 (32.5) 107 (23.5) 54 (28.4) 74 (27.9) 85 (23.0) 111 (24.7) 36 (26.3)
GMCSF
Q1 133 (25.0) 31 (25.0) 127 (25.6) 28 (20.9) 120 (24.5) 42 (28.6) 131 (26.4) 33 (20.8) 116 (25.4) 47 (24.9) 61 (22.8) 101 (27.4) 112 (24.9) 38 (27.7)
Q2 125 (23.5) 40 (32.3) 120 (24.1) 42 (31.3) 123 (25.2) 37 (25.2) 116 (23.3) 49 (30.8) 112 (24.5) 49 (25.9) 62 (23.2) 98 (26.6) 104 (23.2) 43 (31.4)
Q3 129 (24.2) 34 (27.4) 127 (25.6) 32 (23.9) 118 (24.1) 38 (25.9) 125 (25.2) 38 (23.9) 111 (24.3) 50 (26.5) 59 (22.1) 97 (26.3) 121 (26.9) 26 (19.0)
Q4 145 (27.3) 19 (15.3) 123 (24.7) 32 (23.9) 128 (26.2) 30 (20.4) 125 (25.2) 39 (24.5) 118 (25.8) 43 (22.8) 85 (31.8) 73 (19.8) 112 (24.9) 30 (21.9)
IL10
Q1 237 (44.5) 49 (40.5) 221 (44.6) 56 (42.4) 219 (44.8) 61 (42.4) 226 (45.5) 60 (38.5) 206 (45.2) 78 (41.7) 108 (40.8) 173 (47.0) 190 (42.5) 65 (47.8)
Q2 98 (18.4) 24 (19.8) 94 (19.0) 27 (20.5) 88 (18.0) 29 (20.1) 92 (18.5) 30 (19.2) 87 (19.1) 34 (18.2) 45 (17.0) 72 (19.6) 86 (19.2) 20 (14.7)
Q3 98 (18.4) 25 (20.7) 95 (19.2) 24 (18.2) 92 (18.8) 27 (18.8) 93 (18.7) 30 (19.2) 81 (17.8) 39 (20.9) 56 (21.1) 63 (17.1) 88 (19.7) 26 (19.1)
Q4 99 (18.6) 23 (19.0) 86 (17.3) 25 (18.9) 90 (18.4) 27 (18.8) 86 (17.3) 36 (23.1) 82 (18.0) 36 (19.3) 56 (21.1) 60 (16.3) 83 (18.6) 25 (18.4)
IL12P70
Q1 131 (24.7) 32 (26.4) 125 (25.3) 34 (25.6) 120 (24.6) 41 (28.3) 134 (27.0) 29 (18.6) 114 (25.0) 48 (25.8) 56 (21.1) 104 (28.3) 110 (24.6) 37 (27.4)
Q2 138 (26.0) 27 (22.3) 118 (23.9) 38 (28.6) 119 (24.4) 41 (28.3) 127 (25.6) 38 (24.4) 125 (27.4) 37 (19.9) 68 (25.7) 92 (25.1) 114 (25.4) 30 (22.2)
Q3 125 (23.5) 36 (29.8) 121 (24.5) 32 (24.1) 117 (24.0) 36 (24.8) 112 (22.6) 49 (31.4) 109 (23.9) 48 (25.8) 69 (26.0) 85 (23.2) 109 (24.3) 36 (26.7)
Q4 137 (25.8) 26 (21.5) 130 (26.3) 29 (21.8) 131 (26.9) 27 (18.6) 123 (24.8) 40 (25.6) 108 (23.7) 53 (28.5) 72 (27.2) 86 (23.4) 115 (25.7) 32 (23.7)
IL13
Q1 164 (30.8) 41 (33.1) 154 (31.0) 43 (32.1) 147 (30.1) 54 (36.5) 165 (33.2) 40 (25.2) 137 (29.9) 63 (33.5) 73 (27.3) 129 (35.0) 131 (29.2) 49 (35.5)
Q2 120 (22.6) 29 (23.4) 105 (21.1) 36 (26.9) 109 (22.3) 39 (26.4) 113 (22.7) 36 (22.6) 115 (25.1) 33 (17.6) 60 (22.5) 88 (23.8) 108 (24.1) 26 (18.8)
Q3 124 (23.3) 28 (22.6) 126 (25.4) 22 (16.4) 114 (23.4) 29 (19.6) 107 (21.5) 45 (28.3) 101 (22.1) 49 (26.1) 69 (25.8) 73 (19.8) 101 (22.5) 39 (28.3)
Q4 124 (23.3) 26 (21.0) 112 (22.5) 33 (24.6) 118 (24.2) 26 (17.6) 112 (22.5) 38 (23.9) 105 (22.9) 43 (22.9) 65 (24.3) 79 (21.4) 109 (24.3) 24 (17.4)
IL17A
Q1 136 (25.5) 29 (23.6) 123 (24.7) 35 (26.3) 119 (24.3) 42 (28.6) 128 (25.8) 37 (23.3) 122 (26.6) 40 (21.3) 56 (21.0) 104 (28.2) 109 (24.3) 37 (27.0)
Q2 124 (23.3) 39 (31.7) 120 (24.1) 35 (26.3) 111 (22.7) 48 (32.7) 126 (25.4) 37 (23.3) 112 (24.5) 49 (26.1) 64 (24.0) 95 (25.7) 107 (23.8) 41 (29.9)
Q3 136 (25.5) 28 (22.8) 130 (26.1) 31 (23.3) 127 (26.0) 32 (21.8) 127 (25.6) 37 (23.3) 109 (23.8) 53 (28.2) 85 (31.8) 74 (20.1) 120 (26.7) 25 (18.2)
Q4 137 (25.7) 27 (22.0) 125 (25.1) 32 (24.1) 132 (27.0) 25 (17.0) 116 (23.3) 48 (30.2) 115 (25.1) 46 (24.5) 62 (23.2) 96 (26.0) 113 (25.2) 34 (24.8)
IL23
Q1 135 (25.4) 27 (22.7) 119 (24.1) 37 (28.0) 119 (24.3) 40 (28.2) 137 (27.6) 25 (16.1) 114 (25.0) 47 (25.4) 62 (23.6) 96 (26.1) 108 (24.1) 36 (26.9)
Q2 123 (23.1) 40 (33.6) 126 (25.5) 33 (25.0) 118 (24.1) 43 (30.3) 119 (24.0) 44 (28.4) 114 (25.0) 45 (24.3) 63 (24.0) 98 (26.6) 107 (23.9) 43 (32.1)
Q3 136 (25.6) 27 (22.7) 128 (25.9) 29 (22.0) 126 (25.8) 30 (21.1) 126 (25.4) 37 (23.9) 118 (25.9) 43 (23.2) 65 (24.7) 92 (25.0) 116 (25.9) 25 (18.7)
Q4 138 (25.9) 25 (21.0) 121 (24.5) 33 (25.0) 126 (25.8) 29 (20.4) 114 (23.0) 49 (31.6) 110 (24.1) 50 (27.0) 73 (27.8) 82 (22.3) 117 (26.1) 30 (22.4)
IL4
Q1 429 (80.8) 93 (76.9) 397 (80.2) 109 (82.0) 390 (79.9) 120 (83.3) 413 (83.3) 109 (69.9) 376 (82.6) 138 (73.8) 210 (79.5) 300 (81.5) 360 (80.2) 105 (77.8)
Q2 102 (19.2) 28 (23.1) 98 (19.8) 24 (18.0) 98 (20.1) 24 (16.7) 83 (16.7) 47 (30.1) 79 (17.4) 49 (26.2) 54 (20.5) 68 (18.5) 89 (19.8) 30 (22.2)
IL5
Q1 130 (24.4) 33 (27.0) 120 (24.1) 38 (28.6) 115 (23.5) 45 (30.8) 129 (26.0) 34 (21.5) 118 (25.8) 44 (23.4) 53 (19.9) 106 (28.8) 111 (24.8) 36 (26.3)
Q2 131 (24.6) 34 (27.9) 125 (25.2) 33 (24.8) 113 (23.1) 47 (32.2) 126 (25.4) 39 (24.7) 112 (24.5) 51 (27.1) 61 (22.8) 100 (27.2) 105 (23.4) 36 (26.3)
Q3 131 (24.6) 32 (26.2) 120 (24.1) 36 (27.1) 131 (26.8) 25 (17.1) 124 (24.9) 39 (24.7) 115 (25.2) 42 (22.3) 69 (25.8) 87 (23.6) 114 (25.4) 36 (26.3)
Q4 141 (26.5) 23 (18.9) 132 (26.6) 26 (19.5) 130 (26.6) 29 (19.9) 118 (23.7) 46 (29.1) 112 (24.5) 51 (27.1) 84 (31.5) 75 (20.4) 118 (26.3) 29 (21.2)
IL7
Q1 140 (26.8) 23 (20.7) 120 (25.1) 38 (28.8) 125 (26.2) 32 (23.5) 128 (26.3) 35 (23.6) 114 (25.4) 45 (25.6) 67 (25.7) 90 (25.5) 108 (24.6) 37 (28.2)
Q2 124 (23.7) 33 (29.7) 117 (24.4) 33 (25.0) 110 (23.0) 44 (32.4) 122 (25.1) 35 (23.6) 117 (26.1) 38 (21.6) 59 (22.6) 95 (26.9) 107 (24.4) 37 (28.2)
Q3 131 (25.0) 26 (23.4) 121 (25.3) 28 (21.2) 123 (25.7) 29 (21.3) 119 (24.5) 38 (25.7) 107 (23.8) 49 (27.8) 66 (25.3) 86 (24.4) 111 (25.3) 31 (23.7)
Q4 128 (24.5) 29 (26.1) 121 (25.3) 33 (25.0) 120 (25.1) 31 (22.8) 117 (24.1) 40 (27.0) 111 (24.7) 44 (25.0) 69 (26.4) 82 (23.2) 113 (25.7) 26 (19.8)
MIP1A
Q1 139 (26.2) 24 (19.7) 113 (22.9) 42 (31.3) 119 (24.4) 40 (27.6) 129 (26.0) 34 (21.8) 127 (27.8) 33 (17.7) 60 (22.8) 98 (26.5) 122 (27.2) 31 (22.8)
Q2 127 (23.9) 36 (29.5) 126 (25.5) 33 (24.6) 116 (23.8) 41 (28.3) 125 (25.2) 38 (24.4) 116 (25.4) 47 (25.3) 78 (29.7) 80 (21.6) 114 (25.4) 30 (22.1)
Q3 132 (24.9) 32 (26.2) 124 (25.1) 33 (24.6) 129 (26.4) 31 (21.4) 128 (25.8) 36 (23.1) 107 (23.4) 54 (29.0) 62 (23.6) 98 (26.5) 103 (22.9) 40 (29.4)
Q4 133 (25.0) 30 (24.6) 131 (26.5) 26 (19.4) 124 (25.4) 33 (22.8) 115 (23.1) 48 (30.8) 107 (23.4) 52 (28.0) 63 (24.0) 94 (25.4) 110 (24.5) 35 (25.7)
IL1B
Q1 131 (24.7) 31 (27.0) 117 (23.9) 35 (26.5) 113 (23.2) 44 (32.1) 126 (25.5) 36 (23.8) 117 (25.9) 43 (23.4) 60 (22.8) 97 (26.8) 108 (24.3) 38 (28.4)
Q2 128 (24.2) 31 (27.0) 124 (25.4) 32 (24.2) 126 (25.8) 33 (24.1) 129 (26.1) 30 (19.9) 111 (24.6) 46 (25.0) 59 (22.4) 100 (27.6) 111 (25.0) 34 (25.4)
Q3 131 (24.7) 32 (27.8) 127 (26.0) 32 (24.2) 118 (24.2) 37 (27.0) 120 (24.3) 43 (28.5) 108 (23.9) 54 (29.3) 68 (25.9) 87 (24.0) 112 (25.2) 30 (22.4)
Q4 140 (26.4) 21 (18.3) 121 (24.7) 33 (25.0) 131 (26.8) 23 (16.8) 119 (24.1) 42 (27.8) 115 (25.5) 41 (22.3) 76 (28.9) 78 (21.5) 113 (25.5) 32 (23.9)
IL21
Q1 228 (43.6) 40 (35.4) 203 (41.9) 59 (45.7) 204 (42.6) 59 (43.1) 220 (45.0) 48 (32.7) 194 (43.7) 69 (37.7) 103 (39.5) 160 (45.1) 184 (42.0) 55 (41.7)
Q2 96 (18.4) 26 (23.0) 91 (18.8) 27 (20.9) 91 (19.0) 27 (19.7) 94 (19.2) 28 (19.0) 84 (18.9) 36 (19.7) 48 (18.4) 70 (19.7) 81 (18.5) 29 (22.0)
Q3 101 (19.3) 22 (19.5) 92 (19.0) 25 (19.4) 90 (18.8) 25 (18.2) 90 (18.4) 33 (22.4) 89 (20.0) 34 (18.6) 50 (19.2) 65 (18.3) 87 (19.9) 20 (15.2)
Q4 98 (18.7) 25 (22.1) 98 (20.2) 18 (14.0) 94 (19.6) 26 (19.0) 85 (17.4) 38 (25.9) 77 (17.3) 44 (24.0) 60 (23.0) 60 (16.9) 86 (19.6) 28 (21.2)
IL6
Q1 127 (24.1) 31 (29.0) 116 (24.0) 35 (27.3) 111 (22.9) 42 (32.8) 125 (25.6) 33 (22.9) 113 (25.5) 42 (23.3) 57 (22.0) 96 (27.1) 108 (24.7) 35 (26.9)
Q2 132 (25.1) 27 (25.2) 121 (25.1) 33 (25.8) 121 (24.9) 34 (26.6) 130 (26.6) 29 (20.1) 114 (25.7) 43 (23.9) 68 (26.3) 87 (24.6) 116 (26.5) 28 (21.5)
Q3 133 (25.3) 25 (23.4) 124 (25.7) 28 (21.9) 126 (26.0) 26 (20.3) 116 (23.7) 42 (29.2) 110 (24.8) 47 (26.1) 71 (27.4) 81 (22.9) 104 (23.8) 32 (24.6)
Q4 134 (25.5) 24 (22.4) 122 (25.3) 32 (25.0) 127 (26.2) 26 (20.3) 118 (24.1) 40 (27.8) 106 (23.9) 48 (26.7) 63 (24.3) 90 (25.4) 109 (24.9) 35 (26.9)
VEGFA
Q1 88 (26.3) 15 (19.7) 82 (26.7) 17 (18.5) 89 (28.6) 12 (13.8) 86 (27.9) 17 (16.7) 75 (25.6) 28 (25.0) 43 (27.2) 59 (24.5) 71 (26.0) 25 (27.2)
Q2 82 (24.6) 20 (26.3) 75 (24.4) 24 (26.1) 76 (24.4) 21 (24.1) 75 (24.4) 27 (26.5) 69 (23.5) 32 (28.6) 38 (24.1) 60 (24.9) 70 (25.6) 23 (25.0)
Q3 84 (25.1) 19 (25.0) 78 (25.4) 23 (25.0) 79 (25.4) 21 (24.1) 76 (24.7) 27 (26.5) 71 (24.2) 28 (25.0) 38 (24.1) 61 (25.3) 65 (23.8) 23 (25.0)
Q4 80 (24.0) 22 (28.9) 72 (23.5) 28 (30.4) 67 (21.5) 33 (37.9) 71 (23.1) 31 (30.4) 78 (26.6) 24 (21.4) 39 (24.7) 61 (25.3) 67 (24.5) 21 (22.8)
CDCP1
Q1 89 (26.6) 14 (18.4) 82 (26.7) 19 (20.7) 86 (27.7) 14 (16.1) 79 (25.6) 24 (23.5) 60 (20.5) 41 (36.6) 47 (29.7) 54 (22.4) 76 (27.8) 19 (20.7)
Q2 80 (24.0) 22 (28.9) 79 (25.7) 22 (23.9) 73 (23.5) 24 (27.6) 75 (24.4) 27 (26.5) 71 (24.2) 29 (25.9) 35 (22.2) 62 (25.7) 73 (26.7) 20 (21.7)
Q3 83 (24.9) 20 (26.3) 76 (24.8) 24 (26.1) 76 (24.4) 25 (28.7) 80 (26.0) 23 (22.5) 80 (27.3) 23 (20.5) 47 (29.7) 55 (22.8) 63 (23.1) 27 (29.3)
Q4 82 (24.6) 20 (26.3) 70 (22.8) 27 (29.3) 76 (24.4) 24 (27.6) 74 (24.0) 28 (27.5) 82 (28.0) 19 (17.0) 29 (18.4) 70 (29.0) 61 (22.3) 26 (28.3)
CD244
Q1 83 (24.9) 20 (26.3) 78 (25.4) 22 (23.9) 79 (25.4) 19 (21.8) 79 (25.6) 24 (23.5) 72 (24.6) 30 (26.8) 39 (24.7) 59 (24.5) 75 (27.5) 19 (20.7)
Q2 86 (25.7) 16 (21.1) 75 (24.4) 24 (26.1) 78 (25.1) 19 (21.8) 76 (24.7) 26 (25.5) 80 (27.3) 22 (19.6) 36 (22.8) 63 (26.1) 69 (25.3) 19 (20.7)
Q3 82 (24.6) 21 (27.6) 78 (25.4) 22 (23.9) 78 (25.1) 24 (27.6) 75 (24.4) 28 (27.5) 66 (22.5) 36 (32.1) 43 (27.2) 58 (24.1) 64 (23.4) 28 (30.4)
Q4 83 (24.9) 19 (25.0) 76 (24.8) 24 (26.1) 76 (24.4) 25 (28.7) 78 (25.3) 24 (23.5) 75 (25.6) 24 (21.4) 40 (25.3) 61 (25.3) 65 (23.8) 26 (28.3)
OPG
Q1 84 (25.1) 19 (25.0) 74 (24.1) 26 (28.3) 76 (24.4) 22 (25.3) 72 (23.4) 31 (30.4) 69 (23.5) 32 (28.6) 44 (27.8) 55 (22.8) 72 (26.4) 20 (21.7)
Q2 82 (24.6) 20 (26.3) 77 (25.1) 24 (26.1) 70 (22.5) 28 (32.2) 80 (26.0) 22 (21.6) 74 (25.3) 28 (25.0) 39 (24.7) 59 (24.5) 66 (24.2) 24 (26.1)
Q3 84 (25.1) 19 (25.0) 82 (26.7) 16 (17.4) 83 (26.7) 18 (20.7) 80 (26.0) 23 (22.5) 69 (23.5) 31 (27.7) 41 (25.9) 61 (25.3) 72 (26.4) 23 (25.0)
Q4 84 (25.1) 18 (23.7) 74 (24.1) 26 (28.3) 82 (26.4) 19 (21.8) 76 (24.7) 26 (25.5) 81 (27.6) 21 (18.8) 34 (21.5) 66 (27.4) 63 (23.1) 25 (27.2)
LAPTGFB1
Q1 89 (26.6) 14 (18.4) 74 (24.1) 24 (26.1) 87 (28.0) 13 (14.9) 83 (26.9) 20 (19.6) 75 (25.6) 28 (25.0) 42 (26.6) 59 (24.5) 74 (27.1) 21 (22.8)
Q2 83 (24.9) 19 (25.0) 86 (28.0) 14 (15.2) 78 (25.1) 20 (23.0) 75 (24.4) 27 (26.5) 70 (23.9) 31 (27.7) 41 (25.9) 57 (23.7) 71 (26.0) 21 (22.8)
Q3 78 (23.4) 25 (32.9) 74 (24.1) 27 (29.3) 72 (23.2) 26 (29.9) 77 (25.0) 26 (25.5) 71 (24.2) 30 (26.8) 36 (22.8) 63 (26.1) 64 (23.4) 27 (29.3)
Q4 84 (25.1) 18 (23.7) 73 (23.8) 27 (29.3) 74 (23.8) 28 (32.2) 73 (23.7) 29 (28.4) 77 (26.3) 23 (20.5) 39 (24.7) 62 (25.7) 64 (23.4) 23 (25.0)
UPA
Q1 84 (25.1) 19 (25.0) 76 (24.8) 25 (27.2) 77 (24.8) 23 (26.4) 81 (26.3) 22 (21.6) 69 (23.5) 32 (28.6) 38 (24.1) 63 (26.1) 70 (25.6) 26 (28.3)
Q2 81 (24.3) 21 (27.6) 77 (25.1) 22 (23.9) 77 (24.8) 21 (24.1) 72 (23.4) 30 (29.4) 71 (24.2) 30 (26.8) 41 (25.9) 57 (23.7) 67 (24.5) 27 (29.3)
Q3 82 (24.6) 21 (27.6) 78 (25.4) 23 (25.0) 76 (24.4) 23 (26.4) 78 (25.3) 25 (24.5) 72 (24.6) 29 (25.9) 39 (24.7) 60 (24.9) 69 (25.3) 20 (21.7)
Q4 87 (26.0) 15 (19.7) 76 (24.8) 22 (23.9) 81 (26.0) 20 (23.0) 77 (25.0) 25 (24.5) 81 (27.6) 21 (18.8) 40 (25.3) 61 (25.3) 67 (24.5) 19 (20.7)
CST5
Q1 89 (26.6) 14 (18.4) 80 (26.1) 21 (22.8) 85 (27.3) 14 (16.1) 78 (25.3) 25 (24.5) 72 (24.6) 30 (26.8) 42 (26.6) 58 (24.1) 72 (26.4) 19 (20.7)
Q2 75 (22.5) 27 (35.5) 75 (24.4) 25 (27.2) 74 (23.8) 22 (25.3) 74 (24.0) 28 (27.5) 68 (23.2) 34 (30.4) 38 (24.1) 58 (24.1) 66 (24.2) 24 (26.1)
Q3 84 (25.1) 19 (25.0) 79 (25.7) 22 (23.9) 81 (26.0) 22 (25.3) 80 (26.0) 23 (22.5) 72 (24.6) 30 (26.8) 46 (29.1) 57 (23.7) 66 (24.2) 24 (26.1)
Q4 86 (25.7) 16 (21.1) 73 (23.8) 24 (26.1) 71 (22.8) 29 (33.3) 76 (24.7) 26 (25.5) 81 (27.6) 18 (16.1) 32 (20.3) 68 (28.2) 69 (25.3) 25 (27.2)
CD6
Q1 89 (26.6) 14 (18.4) 76 (24.8) 23 (25.0) 83 (26.7) 16 (18.4) 83 (26.9) 20 (19.6) 75 (25.6) 26 (23.2) 46 (29.1) 54 (22.4) 74 (27.1) 18 (19.6)
Q2 88 (26.3) 14 (18.4) 81 (26.4) 20 (21.7) 84 (27.0) 15 (17.2) 83 (26.9) 19 (18.6) 75 (25.6) 25 (22.3) 34 (21.5) 66 (27.4) 70 (25.6) 25 (27.2)
Q3 82 (24.6) 21 (27.6) 78 (25.4) 22 (23.9) 75 (24.1) 26 (29.9) 76 (24.7) 27 (26.5) 78 (26.6) 24 (21.4) 40 (25.3) 61 (25.3) 66 (24.2) 25 (27.2)
Q4 75 (22.5) 27 (35.5) 72 (23.5) 27 (29.3) 69 (22.2) 30 (34.5) 66 (21.4) 36 (35.3) 65 (22.2) 37 (33.0) 38 (24.1) 60 (24.9) 63 (23.1) 24 (26.1)
IL18
Q1 91 (27.2) 12 (15.8) 83 (27.0) 17 (18.5) 86 (27.7) 15 (17.2) 83 (26.9) 20 (19.6) 79 (27.0) 23 (20.5) 46 (29.1) 56 (23.2) 78 (28.6) 16 (17.4)
Q2 78 (23.4) 24 (31.6) 72 (23.5) 27 (29.3) 75 (24.1) 25 (28.7) 80 (26.0) 22 (21.6) 72 (24.6) 29 (25.9) 42 (26.6) 58 (24.1) 68 (24.9) 27 (29.3)
Q3 86 (25.7) 17 (22.4) 84 (27.4) 19 (20.7) 80 (25.7) 21 (24.1) 72 (23.4) 31 (30.4) 72 (24.6) 30 (26.8) 43 (27.2) 58 (24.1) 65 (23.8) 24 (26.1)
Q4 79 (23.7) 23 (30.3) 68 (22.1) 29 (31.5) 70 (22.5) 26 (29.9) 73 (23.7) 29 (28.4) 70 (23.9) 30 (26.8) 27 (17.1) 69 (28.6) 62 (22.7) 25 (27.2)
TNFSF14
Q1 85 (25.4) 18 (23.7) 74 (24.1) 27 (29.3) 79 (25.4) 20 (23.0) 81 (26.3) 22 (21.6) 75 (25.6) 28 (25.0) 42 (26.6) 59 (24.5) 73 (26.7) 22 (23.9)
Q2 81 (24.3) 21 (27.6) 74 (24.1) 25 (27.2) 82 (26.4) 17 (19.5) 77 (25.0) 25 (24.5) 72 (24.6) 27 (24.1) 38 (24.1) 61 (25.3) 66 (24.2) 25 (27.2)
Q3 79 (23.7) 24 (31.6) 78 (25.4) 23 (25.0) 74 (23.8) 27 (31.0) 79 (25.6) 24 (23.5) 67 (22.9) 35 (31.2) 33 (20.9) 67 (27.8) 65 (23.8) 25 (27.2)
Q4 89 (26.6) 13 (17.1) 81 (26.4) 17 (18.5) 76 (24.4) 23 (26.4) 71 (23.1) 31 (30.4) 79 (27.0) 22 (19.6) 45 (28.5) 54 (22.4) 69 (25.3) 20 (21.7)
FGF23
Q1 86 (25.7) 17 (22.4) 79 (25.7) 20 (21.7) 84 (27.0) 18 (20.7) 76 (24.7) 27 (26.5) 71 (24.2) 30 (26.8) 42 (26.6) 59 (24.5) 66 (24.2) 26 (28.3)
Q2 89 (26.6) 13 (17.1) 75 (24.4) 24 (26.1) 80 (25.7) 17 (19.5) 81 (26.3) 21 (20.6) 79 (27.0) 22 (19.6) 36 (22.8) 62 (25.7) 69 (25.3) 21 (22.8)
Q3 81 (24.3) 22 (28.9) 82 (26.7) 21 (22.8) 77 (24.8) 22 (25.3) 79 (25.6) 24 (23.5) 73 (24.9) 28 (25.0) 38 (24.1) 62 (25.7) 70 (25.6) 21 (22.8)
Q4 78 (23.4) 24 (31.6) 71 (23.1) 27 (29.3) 70 (22.5) 30 (34.5) 72 (23.4) 30 (29.4) 70 (23.9) 32 (28.6) 42 (26.6) 58 (24.1) 68 (24.9) 24 (26.1)
LIFR
Q1 81 (24.3) 22 (28.9) 75 (24.4) 24 (26.1) 73 (23.5) 27 (31.0) 73 (23.7) 30 (29.4) 77 (26.3) 26 (23.2) 43 (27.2) 58 (24.1) 76 (27.8) 19 (20.7)
Q2 86 (25.7) 16 (21.1) 78 (25.4) 20 (21.7) 76 (24.4) 22 (25.3) 78 (25.3) 24 (23.5) 72 (24.6) 28 (25.0) 43 (27.2) 55 (22.8) 71 (26.0) 18 (19.6)
Q3 88 (26.3) 15 (19.7) 79 (25.7) 23 (25.0) 84 (27.0) 17 (19.5) 79 (25.6) 24 (23.5) 70 (23.9) 31 (27.7) 42 (26.6) 59 (24.5) 77 (28.2) 15 (16.3)
Q4 79 (23.7) 23 (30.3) 75 (24.4) 25 (27.2) 78 (25.1) 21 (24.1) 78 (25.3) 24 (23.5) 74 (25.3) 27 (24.1) 30 (19.0) 69 (28.6) 49 (17.9) 40 (43.5)
FGF21
Q1 87 (26.0) 16 (21.1) 81 (26.4) 17 (18.5) 83 (26.7) 19 (21.8) 84 (27.3) 19 (18.6) 73 (24.9) 29 (25.9) 49 (31.0) 53 (22.0) 71 (26.0) 22 (23.9)
Q2 83 (24.9) 19 (25.0) 77 (25.1) 24 (26.1) 79 (25.4) 21 (24.1) 74 (24.0) 28 (27.5) 73 (24.9) 29 (25.9) 38 (24.1) 62 (25.7) 66 (24.2) 24 (26.1)
Q3 80 (24.0) 23 (30.3) 77 (25.1) 24 (26.1) 70 (22.5) 27 (31.0) 72 (23.4) 31 (30.4) 66 (22.5) 34 (30.4) 35 (22.2) 64 (26.6) 69 (25.3) 22 (23.9)
Q4 84 (25.1) 18 (23.7) 72 (23.5) 27 (29.3) 79 (25.4) 20 (23.0) 78 (25.3) 24 (23.5) 81 (27.6) 20 (17.9) 36 (22.8) 62 (25.7) 67 (24.5) 24 (26.1)
IL10RB
Q1 83 (24.9) 20 (26.3) 85 (27.7) 16 (17.4) 85 (27.3) 16 (18.4) 77 (25.0) 26 (25.5) 74 (25.3) 28 (25.0) 54 (34.2) 48 (19.9) 77 (28.2) 22 (23.9)
Q2 87 (26.0) 15 (19.7) 75 (24.4) 23 (25.0) 83 (26.7) 15 (17.2) 83 (26.9) 19 (18.6) 74 (25.3) 27 (24.1) 33 (20.9) 65 (27.0) 67 (24.5) 22 (23.9)
Q3 83 (24.9) 20 (26.3) 78 (25.4) 22 (23.9) 74 (23.8) 25 (28.7) 75 (24.4) 28 (27.5) 70 (23.9) 32 (28.6) 42 (26.6) 57 (23.7) 66 (24.2) 23 (25.0)
Q4 81 (24.3) 21 (27.6) 69 (22.5) 31 (33.7) 69 (22.2) 31 (35.6) 73 (23.7) 29 (28.4) 75 (25.6) 25 (22.3) 29 (18.4) 71 (29.5) 63 (23.1) 25 (27.2)
PDL1
Q1 85 (25.4) 18 (23.7) 81 (26.4) 18 (19.6) 81 (26.0) 21 (24.1) 81 (26.3) 22 (21.6) 74 (25.3) 28 (25.0) 44 (27.8) 59 (24.5) 76 (27.8) 19 (20.7)
Q2 81 (24.3) 21 (27.6) 84 (27.4) 18 (19.6) 78 (25.1) 18 (20.7) 78 (25.3) 24 (23.5) 69 (23.5) 33 (29.5) 41 (25.9) 55 (22.8) 63 (23.1) 22 (23.9)
Q3 85 (25.4) 18 (23.7) 75 (24.4) 25 (27.2) 78 (25.1) 23 (26.4) 72 (23.4) 31 (30.4) 73 (24.9) 28 (25.0) 43 (27.2) 58 (24.1) 71 (26.0) 24 (26.1)
Q4 83 (24.9) 19 (25.0) 67 (21.8) 31 (33.7) 74 (23.8) 25 (28.7) 77 (25.0) 25 (24.5) 77 (26.3) 23 (20.5) 30 (19.0) 69 (28.6) 63 (23.1) 27 (29.3)
BNGF
Q1 84 (25.1) 19 (25.0) 80 (26.1) 20 (21.7) 79 (25.4) 21 (24.1) 79 (25.6) 24 (23.5) 66 (22.5) 35 (31.2) 49 (31.0) 52 (21.6) 68 (24.9) 28 (30.4)
Q2 84 (25.1) 18 (23.7) 74 (24.1) 25 (27.2) 75 (24.1) 24 (27.6) 78 (25.3) 24 (23.5) 70 (23.9) 32 (28.6) 41 (25.9) 57 (23.7) 75 (27.5) 17 (18.5)
Q3 86 (25.7) 17 (22.4) 77 (25.1) 25 (27.2) 84 (27.0) 17 (19.5) 77 (25.0) 26 (25.5) 75 (25.6) 26 (23.2) 34 (21.5) 68 (28.2) 65 (23.8) 24 (26.1)
Q4 80 (24.0) 22 (28.9) 76 (24.8) 22 (23.9) 73 (23.5) 25 (28.7) 74 (24.0) 28 (27.5) 82 (28.0) 19 (17.0) 34 (21.5) 64 (26.6) 65 (23.8) 23 (25.0)
IL18R1
Q1 93 (27.8) 10 (13.2) 81 (26.4) 19 (20.7) 89 (28.6) 12 (13.8) 86 (27.9) 17 (16.7) 86 (29.4) 17 (15.2) 49 (31.0) 52 (21.6) 80 (29.3) 15 (16.3)
Q2 85 (25.4) 17 (22.4) 76 (24.8) 23 (25.0) 80 (25.7) 19 (21.8) 70 (22.7) 32 (31.4) 79 (27.0) 21 (18.8) 43 (27.2) 57 (23.7) 67 (24.5) 19 (20.7)
Q3 88 (26.3) 15 (19.7) 73 (23.8) 27 (29.3) 77 (24.8) 21 (24.1) 79 (25.6) 24 (23.5) 70 (23.9) 32 (28.6) 34 (21.5) 65 (27.0) 77 (28.2) 19 (20.7)
Q4 68 (20.4) 34 (44.7) 77 (25.1) 23 (25.0) 65 (20.9) 35 (40.2) 73 (23.7) 29 (28.4) 58 (19.8) 42 (37.5) 32 (20.3) 67 (27.8) 49 (17.9) 39 (42.4)
TRANCE
Q1 88 (26.3) 15 (19.7) 79 (25.7) 20 (21.7) 90 (28.9) 10 (11.5) 83 (26.9) 20 (19.6) 80 (27.3) 22 (19.6) 42 (26.6) 59 (24.5) 73 (26.7) 17 (18.5)
Q2 89 (26.6) 13 (17.1) 78 (25.4) 20 (21.7) 85 (27.3) 17 (19.5) 85 (27.6) 17 (16.7) 69 (23.5) 33 (29.5) 38 (24.1) 63 (26.1) 61 (22.3) 28 (30.4)
Q3 85 (25.4) 18 (23.7) 78 (25.4) 24 (26.1) 79 (25.4) 21 (24.1) 71 (23.1) 32 (31.4) 75 (25.6) 25 (22.3) 48 (30.4) 52 (21.6) 78 (28.6) 15 (16.3)
Q4 72 (21.6) 30 (39.5) 72 (23.5) 28 (30.4) 57 (18.3) 39 (44.8) 69 (22.4) 33 (32.4) 69 (23.5) 32 (28.6) 30 (19.0) 67 (27.8) 61 (22.3) 32 (34.8)
HGF
Q1 89 (26.6) 14 (18.4) 74 (24.1) 25 (27.2) 83 (26.7) 17 (19.5) 85 (27.6) 18 (17.6) 79 (27.0) 24 (21.4) 53 (33.5) 48 (19.9) 77 (28.2) 19 (20.7)
Q2 82 (24.6) 20 (26.3) 78 (25.4) 20 (21.7) 78 (25.1) 21 (24.1) 75 (24.4) 27 (26.5) 72 (24.6) 27 (24.1) 37 (23.4) 63 (26.1) 68 (24.9) 22 (23.9)
Q3 84 (25.1) 19 (25.0) 79 (25.7) 22 (23.9) 85 (27.3) 16 (18.4) 78 (25.3) 25 (24.5) 74 (25.3) 27 (24.1) 32 (20.3) 69 (28.6) 67 (24.5) 25 (27.2)
Q4 79 (23.7) 23 (30.3) 76 (24.8) 25 (27.2) 65 (20.9) 33 (37.9) 70 (22.7) 32 (31.4) 68 (23.2) 34 (30.4) 36 (22.8) 61 (25.3) 61 (22.3) 26 (28.3)
IL12B
Q1 87 (26.0) 16 (21.1) 80 (26.1) 19 (20.7) 85 (27.3) 15 (17.2) 83 (26.9) 20 (19.6) 77 (26.3) 24 (21.4) 36 (22.8) 65 (27.0) 63 (23.1) 25 (27.2)
Q2 88 (26.3) 14 (18.4) 82 (26.7) 18 (19.6) 71 (22.8) 25 (28.7) 83 (26.9) 19 (18.6) 81 (27.6) 21 (18.8) 35 (22.2) 61 (25.3) 82 (30.0) 13 (14.1)
Q3 85 (25.4) 18 (23.7) 74 (24.1) 26 (28.3) 79 (25.4) 22 (25.3) 80 (26.0) 23 (22.5) 72 (24.6) 29 (25.9) 46 (29.1) 55 (22.8) 65 (23.8) 27 (29.3)
Q4 74 (22.2) 28 (36.8) 71 (23.1) 29 (31.5) 76 (24.4) 25 (28.7) 62 (20.1) 40 (39.2) 63 (21.5) 38 (33.9) 41 (25.9) 60 (24.9) 63 (23.1) 27 (29.3)
MMP1
Q1 81 (24.3) 22 (28.9) 75 (24.4) 23 (25.0) 81 (26.0) 19 (21.8) 76 (24.7) 27 (26.5) 67 (22.9) 36 (32.1) 42 (26.6) 59 (24.5) 62 (22.7) 28 (30.4)
Q2 82 (24.6) 20 (26.3) 76 (24.8) 22 (23.9) 70 (22.5) 27 (31.0) 75 (24.4) 27 (26.5) 75 (25.6) 27 (24.1) 36 (22.8) 62 (25.7) 71 (26.0) 18 (19.6)
Q3 85 (25.4) 18 (23.7) 78 (25.4) 24 (26.1) 81 (26.0) 21 (24.1) 84 (27.3) 19 (18.6) 74 (25.3) 27 (24.1) 42 (26.6) 59 (24.5) 68 (24.9) 24 (26.1)
Q4 86 (25.7) 16 (21.1) 78 (25.4) 23 (25.0) 79 (25.4) 20 (23.0) 73 (23.7) 29 (28.4) 77 (26.3) 22 (19.6) 38 (24.1) 61 (25.3) 72 (26.4) 22 (23.9)
MMP10
Q1 77 (23.1) 26 (34.2) 77 (25.1) 23 (25.0) 77 (24.8) 25 (28.7) 74 (24.0) 29 (28.4) 66 (22.5) 36 (32.1) 43 (27.2) 60 (24.9) 70 (25.6) 23 (25.0)
Q2 84 (25.1) 18 (23.7) 82 (26.7) 18 (19.6) 79 (25.4) 19 (21.8) 76 (24.7) 26 (25.5) 70 (23.9) 31 (27.7) 35 (22.2) 63 (26.1) 62 (22.7) 29 (31.5)
Q3 88 (26.3) 15 (19.7) 75 (24.4) 24 (26.1) 78 (25.1) 21 (24.1) 79 (25.6) 24 (23.5) 75 (25.6) 26 (23.2) 37 (23.4) 62 (25.7) 71 (26.0) 21 (22.8)
Q4 85 (25.4) 17 (22.4) 73 (23.8) 27 (29.3) 77 (24.8) 22 (25.3) 79 (25.6) 23 (22.5) 82 (28.0) 19 (17.0) 43 (27.2) 56 (23.2) 70 (25.6) 19 (20.7)
CCL23
Q1 79 (23.7) 24 (31.6) 79 (25.7) 22 (23.9) 78 (25.1) 22 (25.3) 78 (25.3) 25 (24.5) 70 (23.9) 33 (29.5) 41 (25.9) 59 (24.5) 66 (24.2) 26 (28.3)
Q2 81 (24.3) 21 (27.6) 77 (25.1) 21 (22.8) 76 (24.4) 23 (26.4) 76 (24.7) 26 (25.5) 70 (23.9) 28 (25.0) 34 (21.5) 65 (27.0) 68 (24.9) 23 (25.0)
Q3 89 (26.6) 14 (18.4) 78 (25.4) 22 (23.9) 80 (25.7) 20 (23.0) 79 (25.6) 24 (23.5) 78 (26.6) 24 (21.4) 39 (24.7) 61 (25.3) 68 (24.9) 23 (25.0)
Q4 85 (25.4) 17 (22.4) 73 (23.8) 27 (29.3) 77 (24.8) 22 (25.3) 75 (24.4) 27 (26.5) 75 (25.6) 27 (24.1) 44 (27.8) 56 (23.2) 71 (26.0) 20 (21.7)
CD5
Q1 92 (27.5) 11 (14.5) 82 (26.7) 17 (18.5) 90 (28.9) 11 (12.6) 88 (28.6) 15 (14.7) 76 (25.9) 25 (22.3) 47 (29.7) 55 (22.8) 71 (26.0) 22 (23.9)
Q2 85 (25.4) 17 (22.4) 76 (24.8) 25 (27.2) 78 (25.1) 19 (21.8) 79 (25.6) 23 (22.5) 76 (25.9) 25 (22.3) 42 (26.6) 56 (23.2) 73 (26.7) 17 (18.5)
Q3 83 (24.9) 20 (26.3) 83 (27.0) 19 (20.7) 75 (24.1) 26 (29.9) 77 (25.0) 26 (25.5) 72 (24.6) 30 (26.8) 31 (19.6) 69 (28.6) 67 (24.5) 27 (29.3)
Q4 74 (22.2) 28 (36.8) 66 (21.5) 31 (33.7) 68 (21.9) 31 (35.6) 64 (20.8) 38 (37.3) 69 (23.5) 32 (28.6) 38 (24.1) 61 (25.3) 62 (22.7) 26 (28.3)
FLT3L
Q1 85 (25.4) 18 (23.7) 80 (26.1) 20 (21.7) 75 (24.1) 23 (26.4) 75 (24.4) 28 (27.5) 71 (24.2) 30 (26.8) 43 (27.2) 55 (22.8) 72 (26.4) 20 (21.7)
Q2 84 (25.1) 18 (23.7) 79 (25.7) 20 (21.7) 82 (26.4) 17 (19.5) 73 (23.7) 29 (28.4) 79 (27.0) 22 (19.6) 38 (24.1) 62 (25.7) 70 (25.6) 23 (25.0)
Q3 87 (26.0) 16 (21.1) 77 (25.1) 24 (26.1) 79 (25.4) 22 (25.3) 83 (26.9) 20 (19.6) 81 (27.6) 21 (18.8) 40 (25.3) 62 (25.7) 73 (26.7) 17 (18.5)
Q4 78 (23.4) 24 (31.6) 71 (23.1) 28 (30.4) 75 (24.1) 25 (28.7) 77 (25.0) 25 (24.5) 62 (21.2) 39 (34.8) 37 (23.4) 62 (25.7) 58 (21.2) 32 (34.8)
BP14E
Q1 81 (24.3) 22 (28.9) 79 (25.7) 22 (23.9) 76 (24.4) 23 (26.4) 74 (24.0) 29 (28.4) 69 (23.5) 32 (28.6) 35 (22.2) 65 (27.0) 66 (24.2) 21 (22.8)
Q2 84 (25.1) 18 (23.7) 81 (26.4) 17 (18.5) 80 (25.7) 19 (21.8) 77 (25.0) 25 (24.5) 74 (25.3) 25 (22.3) 29 (18.4) 70 (29.0) 71 (26.0) 19 (20.7)
Q3 84 (25.1) 19 (25.0) 83 (27.0) 17 (18.5) 85 (27.3) 17 (19.5) 80 (26.0) 23 (22.5) 74 (25.3) 29 (25.9) 53 (33.5) 49 (20.3) 68 (24.9) 30 (32.6)
Q4 85 (25.4) 17 (22.4) 64 (20.8) 36 (39.1) 70 (22.5) 28 (32.2) 77 (25.0) 25 (24.5) 76 (25.9) 26 (23.2) 41 (25.9) 57 (23.7) 68 (24.9) 22 (23.9)
DNER
Q1 81 (24.3) 22 (28.9) 73 (23.8) 25 (27.2) 77 (24.8) 23 (26.4) 69 (22.4) 34 (33.3) 76 (25.9) 27 (24.1) 33 (20.9) 67 (27.8) 72 (26.4) 20 (21.7)
Q2 85 (25.4) 17 (22.4) 69 (22.5) 32 (34.8) 74 (23.8) 24 (27.6) 74 (24.0) 28 (27.5) 76 (25.9) 25 (22.3) 40 (25.3) 58 (24.1) 67 (24.5) 18 (19.6)
Q3 89 (26.6) 14 (18.4) 79 (25.7) 21 (22.8) 79 (25.4) 19 (21.8) 80 (26.0) 23 (22.5) 73 (24.9) 26 (23.2) 48 (30.4) 51 (21.2) 68 (24.9) 24 (26.1)
Q4 79 (23.7) 23 (30.3) 86 (28.0) 14 (15.2) 81 (26.0) 21 (24.1) 85 (27.6) 17 (16.7) 68 (23.2) 34 (30.4) 37 (23.4) 65 (27.0) 66 (24.2) 30 (32.6)
CD40
Q1 88 (26.3) 15 (19.7) 79 (25.7) 21 (22.8) 79 (25.4) 20 (23.0) 81 (26.3) 22 (21.6) 80 (27.3) 22 (19.6) 43 (27.2) 57 (23.7) 71 (26.0) 20 (21.7)
Q2 81 (24.3) 21 (27.6) 81 (26.4) 19 (20.7) 86 (27.7) 15 (17.2) 78 (25.3) 24 (23.5) 63 (21.5) 38 (33.9) 42 (26.6) 59 (24.5) 73 (26.7) 20 (21.7)
Q3 83 (24.9) 20 (26.3) 68 (22.1) 32 (34.8) 76 (24.4) 22 (25.3) 73 (23.7) 30 (29.4) 74 (25.3) 28 (25.0) 36 (22.8) 63 (26.1) 72 (26.4) 21 (22.8)
Q4 82 (24.6) 20 (26.3) 79 (25.7) 20 (21.7) 70 (22.5) 30 (34.5) 76 (24.7) 26 (25.5) 76 (25.9) 24 (21.4) 37 (23.4) 62 (25.7) 57 (20.9) 31 (33.7)
FGF19
Q1 84 (25.1) 19 (25.0) 78 (25.4) 23 (25.0) 81 (26.0) 16 (18.4) 73 (23.7) 30 (29.4) 62 (21.2) 41 (36.6) 42 (26.6) 56 (23.2) 67 (24.5) 23 (25.0)
Q2 81 (24.3) 21 (27.6) 73 (23.8) 25 (27.2) 78 (25.1) 23 (26.4) 79 (25.6) 23 (22.5) 77 (26.3) 25 (22.3) 47 (29.7) 54 (22.4) 63 (23.1) 30 (32.6)
Q3 84 (25.1) 19 (25.0) 82 (26.7) 17 (18.5) 75 (24.1) 23 (26.4) 78 (25.3) 25 (24.5) 80 (27.3) 21 (18.8) 25 (15.8) 73 (30.3) 68 (24.9) 25 (27.2)
Q4 85 (25.4) 17 (22.4) 74 (24.1) 27 (29.3) 77 (24.8) 25 (28.7) 78 (25.3) 24 (23.5) 74 (25.3) 25 (22.3) 44 (27.8) 58 (24.1) 75 (27.5) 14 (15.2)
CASP8
Q1 89 (26.6) 14 (18.4) 74 (24.1) 26 (28.3) 81 (26.0) 15 (17.2) 76 (24.7) 27 (26.5) 81 (27.6) 21 (18.8) 48 (30.4) 49 (20.3) 72 (26.4) 15 (16.3)
Q2 82 (24.6) 20 (26.3) 79 (25.7) 22 (23.9) 86 (27.7) 14 (16.1) 79 (25.6) 23 (22.5) 65 (22.2) 35 (31.2) 34 (21.5) 67 (27.8) 66 (24.2) 26 (28.3)
Q3 80 (24.0) 23 (30.3) 75 (24.4) 25 (27.2) 74 (23.8) 26 (29.9) 76 (24.7) 27 (26.5) 69 (23.5) 34 (30.4) 44 (27.8) 56 (23.2) 66 (24.2) 25 (27.2)
Q4 83 (24.9) 19 (25.0) 79 (25.7) 19 (20.7) 70 (22.5) 32 (36.8) 77 (25.0) 25 (24.5) 78 (26.6) 22 (19.6) 32 (20.3) 69 (28.6) 69 (25.3) 26 (28.3)
CCL25
Q1 85 (25.4) 18 (23.7) 80 (26.1) 21 (22.8) 70 (22.5) 28 (32.2) 79 (25.6) 24 (23.5) 73 (24.9) 30 (26.8) 42 (26.6) 56 (23.2) 72 (26.4) 14 (15.2)
Q2 80 (24.0) 22 (28.9) 79 (25.7) 23 (25.0) 78 (25.1) 20 (23.0) 75 (24.4) 27 (26.5) 73 (24.9) 26 (23.2) 37 (23.4) 62 (25.7) 67 (24.5) 26 (28.3)
Q3 84 (25.1) 19 (25.0) 75 (24.4) 23 (25.0) 83 (26.7) 18 (20.7) 76 (24.7) 27 (26.5) 73 (24.9) 30 (26.8) 34 (21.5) 67 (27.8) 70 (25.6) 24 (26.1)
Q4 85 (25.4) 17 (22.4) 73 (23.8) 25 (27.2) 80 (25.7) 21 (24.1) 78 (25.3) 24 (23.5) 74 (25.3) 26 (23.2) 45 (28.5) 56 (23.2) 64 (23.4) 28 (30.4)
TNFRSF9
Q1 90 (26.9) 13 (17.1) 83 (27.0) 16 (17.4) 84 (27.0) 17 (19.5) 88 (28.6) 15 (14.7) 76 (25.9) 25 (22.3) 43 (27.2) 59 (24.5) 67 (24.5) 25 (27.2)
Q2 83 (24.9) 19 (25.0) 72 (23.5) 28 (30.4) 80 (25.7) 18 (20.7) 79 (25.6) 23 (22.5) 72 (24.6) 30 (26.8) 34 (21.5) 64 (26.6) 68 (24.9) 21 (22.8)
Q3 87 (26.0) 16 (21.1) 80 (26.1) 22 (23.9) 77 (24.8) 21 (24.1) 76 (24.7) 27 (26.5) 80 (27.3) 22 (19.6) 45 (28.5) 53 (22.0) 68 (24.9) 22 (23.9)
Q4 74 (22.2) 28 (36.8) 72 (23.5) 26 (28.3) 70 (22.5) 31 (35.6) 65 (21.1) 37 (36.3) 65 (22.2) 35 (31.2) 36 (22.8) 65 (27.0) 70 (25.6) 24 (26.1)
TWEAK
Q1 83 (24.9) 20 (26.3) 78 (25.4) 19 (20.7) 80 (25.7) 18 (20.7) 73 (23.7) 30 (29.4) 67 (22.9) 34 (30.4) 39 (24.7) 60 (24.9) 70 (25.6) 22 (23.9)
Q2 80 (24.0) 22 (28.9) 81 (26.4) 19 (20.7) 73 (23.5) 26 (29.9) 82 (26.6) 20 (19.6) 74 (25.3) 27 (24.1) 32 (20.3) 67 (27.8) 62 (22.7) 29 (31.5)
Q3 85 (25.4) 18 (23.7) 74 (24.1) 29 (31.5) 71 (22.8) 28 (32.2) 74 (24.0) 29 (28.4) 77 (26.3) 26 (23.2) 43 (27.2) 56 (23.2) 68 (24.9) 24 (26.1)
Q4 86 (25.7) 16 (21.1) 74 (24.1) 25 (27.2) 87 (28.0) 15 (17.2) 79 (25.6) 23 (22.5) 75 (25.6) 25 (22.3) 44 (27.8) 58 (24.1) 73 (26.7) 17 (18.5)
ST1A1
Q1 103 (30.8) 18 (23.7) 95 (30.9) 22 (23.9) 100 (32.2) 15 (17.2) 90 (29.2) 31 (30.4) 80 (27.3) 38 (33.9) 41 (25.9) 75 (31.1) 78 (28.6) 28 (30.4)
Q2 61 (18.3) 23 (30.3) 63 (20.5) 20 (21.7) 63 (20.3) 19 (21.8) 62 (20.1) 22 (21.6) 55 (18.8) 29 (25.9) 34 (21.5) 48 (19.9) 58 (21.2) 20 (21.7)
Q3 85 (25.4) 18 (23.7) 74 (24.1) 27 (29.3) 76 (24.4) 27 (31.0) 81 (26.3) 22 (21.6) 78 (26.6) 25 (22.3) 47 (29.7) 56 (23.2) 71 (26.0) 21 (22.8)
Q4 85 (25.4) 17 (22.4) 75 (24.4) 23 (25.0) 72 (23.2) 26 (29.9) 75 (24.4) 27 (26.5) 80 (27.3) 20 (17.9) 36 (22.8) 62 (25.7) 66 (24.2) 23 (25.0)
STAMPB
Q1 84 (25.1) 19 (25.0) 78 (25.4) 22 (23.9) 87 (28.0) 12 (13.8) 79 (25.6) 24 (23.5) 70 (23.9) 32 (28.6) 37 (23.4) 63 (26.1) 68 (24.9) 23 (25.0)
Q2 80 (24.0) 22 (28.9) 79 (25.7) 21 (22.8) 73 (23.5) 25 (28.7) 72 (23.4) 30 (29.4) 68 (23.2) 32 (28.6) 40 (25.3) 58 (24.1) 72 (26.4) 18 (19.6)
Q3 84 (25.1) 19 (25.0) 73 (23.8) 25 (27.2) 80 (25.7) 22 (25.3) 79 (25.6) 24 (23.5) 76 (25.9) 27 (24.1) 42 (26.6) 60 (24.9) 63 (23.1) 28 (30.4)
Q4 86 (25.7) 16 (21.1) 77 (25.1) 24 (26.1) 71 (22.8) 28 (32.2) 78 (25.3) 24 (23.5) 79 (27.0) 21 (18.8) 39 (24.7) 60 (24.9) 70 (25.6) 23 (25.0)
ADA
Q1 86 (25.7) 17 (22.4) 74 (24.1) 25 (27.2) 82 (26.4) 18 (20.7) 73 (23.7) 30 (29.4) 80 (27.3) 21 (18.8) 43 (27.2) 59 (24.5) 79 (28.9) 14 (15.2)
Q2 82 (24.6) 20 (26.3) 76 (24.8) 25 (27.2) 76 (24.4) 19 (21.8) 79 (25.6) 23 (22.5) 76 (25.9) 26 (23.2) 40 (25.3) 55 (22.8) 64 (23.4) 23 (25.0)
Q3 84 (25.1) 19 (25.0) 75 (24.4) 25 (27.2) 74 (23.8) 28 (32.2) 79 (25.6) 24 (23.5) 66 (22.5) 36 (32.1) 33 (20.9) 69 (28.6) 74 (27.1) 18 (19.6)
Q4 82 (24.6) 20 (26.3) 82 (26.7) 17 (18.5) 79 (25.4) 22 (25.3) 77 (25.0) 25 (24.5) 71 (24.2) 29 (25.9) 42 (26.6) 58 (24.1) 56 (20.5) 37 (40.2)
TNFB
Q1 86 (25.7) 17 (22.4) 80 (26.1) 18 (19.6) 89 (28.6) 12 (13.8) 89 (28.9) 14 (13.7) 70 (23.9) 30 (26.8) 35 (22.2) 67 (27.8) 67 (24.5) 24 (26.1)
Q2 94 (28.1) 8 (10.5) 82 (26.7) 19 (20.7) 76 (24.4) 19 (21.8) 81 (26.3) 21 (20.6) 79 (27.0) 23 (20.5) 35 (22.2) 61 (25.3) 70 (25.6) 20 (21.7)
Q3 77 (23.1) 26 (34.2) 74 (24.1) 27 (29.3) 73 (23.5) 29 (33.3) 73 (23.7) 30 (29.4) 72 (24.6) 29 (25.9) 35 (22.2) 67 (27.8) 71 (26.0) 22 (23.9)
Q4 77 (23.1) 25 (32.9) 71 (23.1) 28 (30.4) 73 (23.5) 27 (31.0) 65 (21.1) 37 (36.3) 72 (24.6) 30 (26.8) 53 (33.5) 46 (19.1) 65 (23.8) 26 (28.3)
CSF1
Q1 86 (25.7) 17 (22.4) 81 (26.4) 18 (19.6) 82 (26.4) 18 (20.7) 84 (27.3) 19 (18.6) 77 (26.3) 25 (22.3) 46 (29.1) 55 (22.8) 69 (25.3) 21 (22.8)
Q2 82 (24.6) 20 (26.3) 75 (24.4) 23 (25.0) 74 (23.8) 26 (29.9) 78 (25.3) 24 (23.5) 70 (23.9) 31 (27.7) 38 (24.1) 61 (25.3) 68 (24.9) 27 (29.3)
Q3 86 (25.7) 17 (22.4) 77 (25.1) 25 (27.2) 76 (24.4) 23 (26.4) 75 (24.4) 28 (27.5) 78 (26.6) 24 (21.4) 38 (24.1) 62 (25.7) 73 (26.7) 19 (20.7)
Q4 80 (24.0) 22 (28.9) 74 (24.1) 26 (28.3) 79 (25.4) 20 (23.0) 71 (23.1) 31 (30.4) 68 (23.2) 32 (28.6) 36 (22.8) 63 (26.1) 63 (23.1) 25 (27.2)
ENRAGE
Q1 88 (26.3) 15 (19.7) 80 (26.1) 21 (22.8) 83 (26.7) 17 (19.5) 80 (26.0) 23 (22.5) 79 (27.0) 22 (19.6) 47 (29.7) 54 (22.4) 77 (28.2) 20 (21.7)
Q2 82 (24.6) 20 (26.3) 77 (25.1) 22 (23.9) 80 (25.7) 21 (24.1) 78 (25.3) 24 (23.5) 66 (22.5) 35 (31.2) 34 (21.5) 67 (27.8) 69 (25.3) 20 (21.7)
Q3 80 (24.0) 23 (30.3) 72 (23.5) 28 (30.4) 79 (25.4) 18 (20.7) 78 (25.3) 25 (24.5) 72 (24.6) 30 (26.8) 35 (22.2) 63 (26.1) 53 (19.4) 36 (39.1)
Q4 84 (25.1) 18 (23.7) 78 (25.4) 21 (22.8) 69 (22.2) 31 (35.6) 72 (23.4) 30 (29.4) 76 (25.9) 25 (22.3) 42 (26.6) 57 (23.7) 74 (27.1) 16 (17.4)
MCP3
Q1 87 (26.0) 16 (21.1) 74 (24.1) 25 (27.2) 79 (25.4) 23 (26.4) 79 (25.6) 24 (23.5) 86 (29.4) 15 (13.4) 43 (27.2) 59 (24.5) 74 (27.1) 17 (18.5)
Q2 82 (24.6) 20 (26.3) 82 (26.7) 19 (20.7) 78 (25.1) 19 (21.8) 77 (25.0) 25 (24.5) 70 (23.9) 32 (28.6) 35 (22.2) 63 (26.1) 72 (26.4) 21 (22.8)
Q3 88 (26.3) 15 (19.7) 73 (23.8) 27 (29.3) 74 (23.8) 24 (27.6) 79 (25.6) 24 (23.5) 78 (26.6) 24 (21.4) 43 (27.2) 54 (22.4) 68 (24.9) 19 (20.7)
Q4 77 (23.1) 25 (32.9) 78 (25.4) 21 (22.8) 80 (25.7) 21 (24.1) 73 (23.7) 29 (28.4) 59 (20.1) 41 (36.6) 37 (23.4) 65 (27.0) 59 (21.6) 35 (38.0)
OSM
Q1 83 (24.9) 20 (26.3) 74 (24.1) 28 (30.4) 75 (24.1) 26 (29.9) 81 (26.3) 22 (21.6) 76 (25.9) 26 (23.2) 45 (28.5) 56 (23.2) 74 (27.1) 24 (26.1)
Q2 77 (23.1) 25 (32.9) 72 (23.5) 26 (28.3) 77 (24.8) 21 (24.1) 70 (22.7) 32 (31.4) 71 (24.2) 29 (25.9) 33 (20.9) 66 (27.4) 62 (22.7) 27 (29.3)
Q3 86 (25.7) 17 (22.4) 77 (25.1) 21 (22.8) 86 (27.7) 14 (16.1) 84 (27.3) 19 (18.6) 73 (24.9) 29 (25.9) 35 (22.2) 65 (27.0) 67 (24.5) 20 (21.7)
Q4 88 (26.3) 14 (18.4) 84 (27.4) 17 (18.5) 73 (23.5) 26 (29.9) 73 (23.7) 29 (28.4) 73 (24.9) 28 (25.0) 45 (28.5) 54 (22.4) 70 (25.6) 21 (22.8)
CCL28
Q1 95 (28.4) 34 (44.7) 100 (32.6) 25 (27.2) 95 (30.5) 28 (32.2) 88 (28.6) 41 (40.2) 76 (25.9) 51 (45.5) 48 (30.4) 74 (30.7) 79 (28.9) 35 (38.0)
Q2 61 (18.3) 15 (19.7) 53 (17.3) 22 (23.9) 57 (18.3) 17 (19.5) 58 (18.8) 18 (17.6) 54 (18.4) 20 (17.9) 21 (13.3) 54 (22.4) 55 (20.1) 14 (15.2)
Q3 85 (25.4) 18 (23.7) 77 (25.1) 22 (23.9) 76 (24.4) 25 (28.7) 78 (25.3) 25 (24.5) 78 (26.6) 25 (22.3) 44 (27.8) 58 (24.1) 67 (24.5) 23 (25.0)
Q4 93 (27.8) 9 (11.8) 77 (25.1) 23 (25.0) 83 (26.7) 17 (19.5) 84 (27.3) 18 (17.6) 85 (29.0) 16 (14.3) 45 (28.5) 55 (22.8) 72 (26.4) 20 (21.7)
SLAMF1
Q1 88 (26.3) 15 (19.7) 79 (25.7) 22 (23.9) 84 (27.0) 17 (19.5) 84 (27.3) 19 (18.6) 72 (24.6) 28 (25.0) 35 (22.2) 66 (27.4) 71 (26.0) 24 (26.1)
Q2 87 (26.0) 15 (19.7) 80 (26.1) 20 (21.7) 79 (25.4) 18 (20.7) 77 (25.0) 25 (24.5) 72 (24.6) 29 (25.9) 47 (29.7) 52 (21.6) 70 (25.6) 23 (25.0)
Q3 79 (23.7) 24 (31.6) 70 (22.8) 31 (33.7) 72 (23.2) 29 (33.3) 75 (24.4) 28 (27.5) 73 (24.9) 29 (25.9) 39 (24.7) 62 (25.7) 63 (23.1) 22 (23.9)
Q4 80 (24.0) 22 (28.9) 78 (25.4) 19 (20.7) 76 (24.4) 23 (26.4) 72 (23.4) 30 (29.4) 76 (25.9) 26 (23.2) 37 (23.4) 61 (25.3) 69 (25.3) 23 (25.0)
IL17C
Q1 297 (88.9) 64 (84.2) 269 (87.6) 82 (89.1) 275 (88.4) 75 (86.2) 274 (89.0) 87 (85.3) 251 (85.7) 105 (93.8) 146 (92.4) 205 (85.1) 237 (86.8) 83 (90.2)
Q2 37 (11.1) 12 (15.8) 38 (12.4) 10 (10.9) 36 (11.6) 12 (13.8) 34 (11.0) 15 (14.7) 42 (14.3) 7 ( 6.2) 12 ( 7.6) 36 (14.9) 36 (13.2) 9 ( 9.8)
AXIN1
Q1 194 (58.1) 43 (56.6) 181 (59.0) 50 (54.3) 188 (60.5) 41 (47.1) 178 (57.8) 59 (57.8) 162 (55.3) 72 (64.3) 91 (57.6) 139 (57.7) 157 (57.5) 52 (56.5)
Q2 66 (19.8) 21 (27.6) 65 (21.2) 18 (19.6) 66 (21.2) 20 (23.0) 64 (20.8) 23 (22.5) 60 (20.5) 27 (24.1) 31 (19.6) 55 (22.8) 60 (22.0) 18 (19.6)
Q3 74 (22.2) 12 (15.8) 61 (19.9) 24 (26.1) 57 (18.3) 26 (29.9) 66 (21.4) 20 (19.6) 71 (24.2) 13 (11.6) 36 (22.8) 47 (19.5) 56 (20.5) 22 (23.9)
SIRT2
Q1 209 (62.6) 51 (67.1) 195 (63.5) 57 (62.0) 201 (64.6) 50 (57.5) 198 (64.3) 62 (60.8) 177 (60.4) 80 (71.4) 100 (63.3) 152 (63.1) 171 (62.6) 57 (62.0)
Q2 63 (18.9) 12 (15.8) 57 (18.6) 15 (16.3) 60 (19.3) 13 (14.9) 54 (17.5) 21 (20.6) 62 (21.2) 13 (11.6) 27 (17.1) 47 (19.5) 53 (19.4) 16 (17.4)
Q3 62 (18.6) 13 (17.1) 55 (17.9) 20 (21.7) 50 (16.1) 24 (27.6) 56 (18.2) 19 (18.6) 54 (18.4) 19 (17.0) 31 (19.6) 42 (17.4) 49 (17.9) 19 (20.7)
IL10RA
Q1 224 (67.1) 55 (72.4) 210 (68.4) 64 (69.6) 211 (67.8) 60 (69.0) 207 (67.2) 72 (70.6) 200 (68.3) 75 (67.0) 99 (62.7) 172 (71.4) 191 (70.0) 61 (66.3)
Q2 55 (16.5) 11 (14.5) 45 (14.7) 16 (17.4) 51 (16.4) 13 (14.9) 49 (15.9) 17 (16.7) 47 (16.0) 18 (16.1) 32 (20.3) 32 (13.3) 39 (14.3) 16 (17.4)
Q3 55 (16.5) 10 (13.2) 52 (16.9) 12 (13.0) 49 (15.8) 14 (16.1) 52 (16.9) 13 (12.7) 46 (15.7) 19 (17.0) 27 (17.1) 37 (15.4) 43 (15.8) 15 (16.3)
NT3
Q1 208 (62.3) 42 (55.3) 185 (60.3) 57 (62.0) 203 (65.3) 39 (44.8) 189 (61.4) 61 (59.8) 181 (61.8) 65 (58.0) 96 (60.8) 146 (60.6) 165 (60.4) 62 (67.4)
Q2 63 (18.9) 17 (22.4) 64 (20.8) 14 (15.2) 55 (17.7) 24 (27.6) 62 (20.1) 18 (17.6) 56 (19.1) 23 (20.5) 32 (20.3) 48 (19.9) 54 (19.8) 16 (17.4)
Q3 63 (18.9) 17 (22.4) 58 (18.9) 21 (22.8) 53 (17.0) 24 (27.6) 57 (18.5) 23 (22.5) 56 (19.1) 24 (21.4) 30 (19.0) 47 (19.5) 54 (19.8) 14 (15.2)
All Values presented as N(%)
Figure S1. Heatmap of Pearson’s correlation coefficients for log transformed marker levels among markers associated with AHA/NHLBI metabolic syndrome
(left) or low physical activity (right). Markers are ordered according to similarity as determined by hierarchical clustering.
Asterisks denote level of statistical significance: * P < 0.05, ** P < 0.01, *** P < 0.001.