Table S1. Complete list of markers and quantile ......SAP Serum amyloid P 100.0 ≤44444000 44502000-56756000 56762000-71779000 ≥71809000 pg/mL SCF Stem cell factor 90.5 ≤16.6

Table S1. Complete list of markers and quantile classifications included in analyses.

Abbreviation Common Name % Detectable Q1 Q2 Q3 Q4

MILLIPLEX MARKERS

CCL11/EOTAXIN CC motif ligand chemokine 11 100.0 ≤321.25 321.33-411.54 411.68-509.28 ≥509.51

CCL13/MCP4 CC motif ligand chemokine 13 55.9 <39.06 [LLOD] 39.58-58.68 58.71-84.26 ≥84.42

CCL15/MIP1D CC motif ligand chemokine 15 100.0 ≤2446.43 2450.04-3384.02 3384.87-5308.52 ≥5313.51

CCL17/TARC CC motif ligand chemokine 17 100.0 ≤13.79 13.8-19.14 19.15-27.75 ≥27.8

CCL19/MIP3B CC motif ligand chemokine 19 100.0 ≤119.84 119.86-158.87 158.93-217.54 ≥217.58

CCL2/MCP1 CC motif ligand chemokine 2 100.0 ≤445.38 445.4-549.69 549.89-674.99 ≥675.25

CCL20/MIP3A CC motif ligand chemokine 20 94.0 ≤5.15 5.16-7.92 7.95-12.22 ≥12.24

CCL21/6CKINE CC motif ligand chemokine 21 57.9 <78.13 [LLOD] 80.99-162.81 163.58-263.51 ≥264.02

CCL22/MDC CC motif ligand chemokine 22 100.0 ≤485.6 485.63-589.94 590.02-727.26 ≥727.52

CCL24/EOTAXIN2 CC motif ligand chemokine 24 99.8 ≤113.36 113.41-176.33 176.47-264.49 ≥264.92

CCL27/CTACK CC motif ligand chemokine 27 100.0 ≤589.96 590.34-726.74 727.28-888.33 ≥888.69

CCL3/MIP1A CC motif ligand chemokine 3 88.6 ≤28.96 28.99-43.08 43.14-75.13 ≥75.15

CCL4/MIP1B CC motif ligand chemokine 4 97.1 ≤38.66 38.75-59.72 59.81-102.3 ≥102.46

CCL8/MCP2 CC motif ligand chemokine 8 81.2 ≤8.98 8.99-16.79 16.84-23.33 ≥23.34

CRP C Reactive Protein 100.0 ≤2222800 2226700-4893900 4899900-10321000 ≥10355000

CX3CL1/

FRACTALKINE CX3C motif ligand chemokine 1 75.6 ≤44.63 48.97-227.76 228.76-401.59 ≥401.75

CXCL1/GRO CXC motif ligand chemokine 1 100.0 ≤707.21 708.28-955.63 956.08-1278.79 ≥1281.83

CXCL10/IP-10 CXC motif lignad chemokine 10 100.0 ≤430.13 430.25-568.57 568.78-749.24 ≥749.91

CXCL11/I-TAC CXC motif ligand chemokine 11 100.0 ≤166.27 166.42-225.33 226.23-302.8 ≥303.03

CXCL12/SDF1 CXC motif ligand chemokine 12 99.9 ≤1087.61 1088.95-1387.2 1387.39-1755.8 ≥1756.25

CXCL13/BCA1 CXC motif ligand chemokine 13 100.0 ≤17.02 17.06-22.89 22.96-30.66 ≥30.73

CXCL5/ENA78 CXC motif ligand chemokine 5 100.0 ≤296.4 296.49-441.52 442.23-745.01 ≥745.78

CXCL6/GCP2 CXC motif ligand chemokine 6 100.0 ≤45.7 45.74-61.6 61.69-80.66 ≥80.75

CXCL8/IL8 Interleukin 8 99.7 ≤10.57 10.59-22.06 22.07-78.81 ≥78.82

CXCL9/MIG CXC motif ligand chemokine 9 100.0 ≤758.7 758.75-1046.2 1046.94-1547.62 ≥1549.64

EGF Epidermal growth factor 90.1 ≤28.39 28.44-49.06 49.08-97.56 ≥97.68

FGF2/BFGF Fibroblast growth factor 2 65.0 <16 [LLOD] 16.37-119.84 120.9-219.35 ≥220.42

GCSF

Granulocyte-colony stimulating

factor 78.9 ≤21.42 21.46-44.01 44.02-71.71 ≥71.74

GM-CSF

Granulocyte-macrophage colony-

stimulating factor 87.1 ≤24.07 24.13-53.11 53.14-88.87 ≥88.94

IL10 Interleukin 10 56.8 <1.48 [LLOD] 1.48-7.89 7.93-14.87 ≥14.88

IL12/P70 Interleukin 12 p70 87.3 ≤3.54 3.55-7.49 7.52-11.65 ≥11.66


IL16 Interleukin 16 93.5 ≤34.11 34.15-49.82 49.86-71.23 ≥71.36

IL17A Interleukin 17 alpha 88.0 ≤4.58 4.61-9.01 9.06-16.47 ≥16.48

IL1B Interleukin 1 beta 73.3 <0.48 [LLOD] 0.48-2.1 2.11-3.5 ≥3.51

IL1RA Interleukin 1 receptor alpha 66.3 <16 [LLOD] 16.1-55.05 55.27-116.93 ≥117.11


IL23 Interleukin 23 81.6 ≤86.56 86.74-215.14 215.44-438.34 ≥439.94

IL29/IFNL1 Interleukin 29 21.0 <48.83 [LLOD] ≥66.62

IL33 Interleukin 33 22.5 <4.88 [LLOD] >=4.9

IL4 Interleukin 4 19.9 <7.32 [LLOD] ≥7.4

IL5 Interleukin 5 85.6 ≤1.64 1.65-3.67 3.68-6.03 ≥6.04

IL6 Interleukin 6 87.5 ≤1.17 1.18-2.35 2.36-3.85 ≥3.86

IL7 Interleukin 7 74.0 <1.48 [LLOD] 1.48-6.96 7-11.11 ≥11.12

SAA Serum amyloid A 96.2 ≤1657200 1657600-3113400 3114300-6467600 ≥6471400

SAP Serum amyloid P 100.0 ≤44444000 44502000-56756000 56762000-71779000 ≥71809000

pg/mL

SCF Stem cell factor 90.5 ≤16.6 16.63-26.05 26.08-37.55 ≥37.63

sEGFR

Soluble epidermal growth factor

receptor 99.9 ≤92894.67 92927.02-104158.65

sGP130 Soluble glycoprotein 130 99.9 ≤243357.3 243403.38-281952.39 281979.26-320430.17 ≥320665.79

sIL4R Soluble interleukin 4 receptor 98.1 ≤504.13 505.36-616.34 616.67-800.69 ≥801.06

sIL6R Soluble interleukin 6 receptor 99.9 ≤24936.58 24949.38-32436.14 32444.12-40459.99 ≥40466.21

sILR2

Soluble interleukin 1 receptor,

type II 99.9 ≤6535.87 6547.17-8201.33 8204.02-10498.9 ≥10508.22

sTNFR1

Soluble tumor necrosis factor

receptor, type I 99.9 ≤1544.36 1544.77-1850.02 1850.77-2203.51 ≥2206.45

sTNFR2

Soluble tumor necrosis factor

receptor, type II 99.9 ≤6418.29 6428.68-7754.05 7756.04-9379.25 ≥9380.91

sVEGFR2

Soluble vascular endothelial

growth factor receptor 2 99.9 ≤14204.35 14229.21-16719.06 16720.56-20370 ≥20418.65

sVEGFR3

Soluble vascular endothelial

growth factor receptor 3 97.9 ≤2385.38 2398.13-3563.49 3565.45-5000.05 ≥5022.33

TGFA Transforming growth factor alpha 81.7 ≤1.01 1.02-2.29 2.3-4.32 ≥4.33

TNFA Tumor necrosis factor alpha 100.0 ≤12.07 12.08-16.53 16.54-24.97 ≥24.99

TPO Thrombopoietin 100.0 ≤190.44 190.47-245.39 245.62-328.19 ≥328.33

TRAIL

Tumor necrosis factor related

apoptosis inducing ligand 99.5 ≤43.55 43.58-56.49 56.59-71.98 ≥72

TSLP Thymic stromal lymphopoietin 15.1 <2.44 [LLOD] ≥2.44

VEGF

Vascular endothelial growth

factor 63.1 <16 [LLOD] 21.02-167.93 168.9-295.97 ≥296.41

PROSEEK MARKERS

ADA Adenosine deaminase 100.0 ≤ 3.53 3.53 - < 3.73 3.73 - < 3.92 ≥ 3.92

AXIN1 Axin 1 46.9 ≤ 2.02 2.02 - < 3.99

BNGF Beta nerve growth factor 99.2 ≤ 1.39 1.41 - < 1.58 1.59 - < 1.79 ≥ 1.79

CASP8 Caspase 8 99.0 ≤ 3.91 3.91 - < 4.27 4.27 - < 4.82 ≥ 4.82

CCL23/MIP3 CC motif ligand chemokine 23 100.0 ≤ 8.84 8.84 - < 9.13 9.13 - < 9.40 ≥ 9.41

CCL25/TECK CC motif ligand chemokine 25 71.6 ≤ 5.32 5.32 - < 5.69 5.69 - < 6.07 ≥ 6.08

CCL28/MEC CC motif ligand chemokine 28 71.6 ≤ 1.36 1.36 - < 1.56

CD244 Natural killer cell receptor 2B4 100.0 ≤ 5.64 5.64 - < 5.81 5.81 - < 6.04 ≥ 6.04

CD40 CD 40L Receptor 100.0 ≤ 9.36 9.36 - < 9.56 9.56 - < 9.80 ≥ 9.80

CD5 T-cell surface glycoprotein CD5 100.0 ≤ 4.75 4.75 - < 4.95 4.95 - < 5.18 ≥ 5.18

CD6 T-cell surface glycoprotein CD6 100.0 ≤ 4.38 4.38 - < 4.65 4.65 - < 4.92 ≥ 4.92

CDCP1 CUB domain containing protein 1 100.0 ≤ 3.64 3.65 - < 4.05 4.07 - < 4.57 ≥ 4.57

CSF1 Colony stimulating factor 1 100.0 ≤ 7.58 7.58 - < 7.70 7.70 - < 7.84 ≥ 7.84

CST5 Cystatin-D 100.0 ≤ 6.06 6.06 - < 6.36 6.36 - < 6.75 ≥ 6.76

DNER

Delta/Notch like EGF repeat

containing protein 100.0≤ 8.31 8.31 - < 8.48 8.48 - < 8.65

≥ 8.65

ENRAGE

Extracellular newly identified

receptor for advanced glycation

end-products 99.0

≤ 2.59 2.61 - < 3.12 3.12 - < 3.69

≥ 3.71

FGF19 Fibroblast growth factor 19 100.0 ≤ 7.76 7.77 - < 8.48 8.48 - < 9.17 ≥ 9.17



FLT3L

Fms related tyrosine kinase 3

ligand 100.0≤ 8.51 8.52 - < 8.79 8.79 - < 9.06

≥ 9.06

HGF Hepatocyte growth factor 100.0 ≤ 7.70 7.70 - < 7.94 7.94 - < 8.24 ≥ 8.24

IL10RA Interleukin 10 receptor alpha 35.0 ≤ 1.12 1.12 - < 6.62

IL10RB Interleukin 10 receptor beta 100.0 ≤ 6.75 6.75 - < 6.95 6.95 - < 7.15 ≥ 7.16

IL12B Interleukin 12 beta 100.0 ≤ 3.20 3.20 - < 3.60 3.61 - < 3.93 ≥ 3.93

IL17C Interleukin 17C 14.7 ≤ 4.10 ≥ 4.10

IL18R1 Interleukin 18 receptor 1 100.0 ≤ 6.65 6.65 - < 6.88 6.88 - < 7.09 ≥ 7.10

IL18 Interleukin 18 100.0 ≤ 6.89 6.89 - < 7.19 7.19 - < 7.55 ≥ 7.55

TGFB1/LAB

Transforming growth factor beta

1 100.0 ≤ 6.91 6.91 - < 7.12 7.12 - < 7.38 ≥ 7.39

NPX values

LIFR

Leukemia inhibitory factor

receptor 100.0≤ 2.83 2.83 - < 3.00 3.00 - < 3.18

≥ 3.18

CCL7/MCP3

CC motif ligand chemokine

7/MCP3 95.9≤ 2.47 2.48 - < 2.76 2.76 - < 3.16

≥ 3.16

MMP1 Matrix metalloproteinase 1 100.0 ≤ 11.53 11.54 - < 12.13 12.13 - < 12.78 ≥ 12.79

MMP10 Matrix metalloproteinase 10 100.0 ≤ 6.08 6.08 - < 6.44 6.44 - < 6.89 ≥ 6.90

NT3 Neurotrophin 3 38.2 ≤ 1.47 1.47 - < 3.57

OPG Osteoprotegrin 100.0 ≤ 10.18 10.18 - < 10.41 10.41 - < 10.59 ≥ 10.60

OSM Oncostatin M 92.3 ≤ 2.08 2.10 - < 3.20 3.21 - < 4.18 ≥ 4.20

PDL1 Programmed cell death ligand 1 100.0 ≤ 3.45 3.46 - < 3.67 3.67 - < 3.87 ≥ 3.90

SIRT2 SIR2-like protein 2 37.0 ≤ 1.93 1.93 - < 6.79

SLAMF1

Signaling lymphocytic activation

molecule 78.3≤ 1.44 1.44 - < 1.70 1.70 - < 1.98

≥ 1.99

ST1A1 Sulfotransferase 1A1 74.0 ≤ 1.92 1.92 - < 2.82 2.83 - < 4.97

STAMPB STAM binding protein 100.0 ≤ 3.37 3.37 - < 3.70 3.71 - < 4.23 ≥ 4.24

TNFB Tumor necrosis factor beta 100.0 ≤ 3.30 3.30 - < 3.58 3.58 - < 3.87 ≥ 3.88

TNFRSF9

Tumor necrosis factor receptor

superfamily 9 100.0≤ 5.65 5.65 - < 5.90 5.90 - < 6.19

≥ 6.19

TNFSF14

Tumor necrosis factor

superfamily 14 100.0≤ 4.25 4.25 - < 4.83 4.84 - < 5.55

≥ 5.55

TRANCE

Tumor necrosis factor activation

induced cytokine 100.0≤ 3.22 3.22 - < 3.64 3.64 - < 4.06

≥ 4.07

TWEAK

Tumor necrosis factor ligand

superfamily member 12 100.0≤ 8.70 8.70 - < 8.89 8.90 - < 9.13

≥ 9.13

UPA

Urokinase-type plasminogen

activator 100.0≤ 10.08 10.08 - < 10.28 10.28 - < 10.49

≥ 10.49

VEGFA

Vascular endothelial growth

factor alpha 100.0≤ 8.65 8.66 - < 8.89 8.89 - < 9.15

≥ 9.15

4E-BP1

Eukaryotic translation initiation

factor 4E-binding protein 1 100.0≤ 4.24 4.24 - < 4.87 4.88 - < 5.61

≥ 5.61

Table S2. Associations between AHA/NHLBI metabolic syndrome and marker quantiles.

OR1 (95% CI) OR2 (95% CI) FDR P-Value

CCL21/6CKINE 1.09 (0.79 - 1.51) 1.10 (0.78 - 1.53) 0.783

CXCL13/BCA1 1.40 (1.01 - 1.93) 1.41 (1.02 - 1.96) 0.226

CCL19/MIP3B 2.11 (1.53 - 2.93) 2.06 (1.48 - 2.88) 0.001

CCL20/MIP3A 1.27 (0.91 - 1.78) 1.21 (0.86 - 1.71) 0.606

CRP 2.22 (1.60 - 3.08) 2.07 (1.48 - 2.90) 0.001

CCL27/CTACK 0.81 (0.58 - 1.11) 0.71 (0.51 - 0.99) 0.226

CXCL11/ITAC 1.35 (0.98 - 1.86) 1.27 (0.92 - 1.77) 0.495

CXCL6/GCP2 1.33 (0.96 - 1.85) 1.29 (0.92 - 1.81) 0.493

CXCL9/MIG 1.24 (0.89 - 1.72) 1.16 (0.83 - 1.62) 0.685

EGF 0.91 (0.65 - 1.26) 0.99 (0.71 - 1.39) 0.975

CXCL5/ENA78 1.02 (0.74 - 1.41) 1.06 (0.76 - 1.48) 0.879

CCL24/EOTAXIN2 1.21 (0.88 - 1.68) 1.27 (0.91 - 1.78) 0.499

CCL11/EOTAXIN 0.86 (0.61 - 1.19) 0.83 (0.59 - 1.17) 0.606

FGF2 0.90 (0.66 - 1.25) 0.88 (0.64 - 1.23) 0.764

CX3CL1/FRACTALKINE 0.97 (0.67 - 1.39) 0.95 (0.65 - 1.37) 0.898

GCSF 0.93 (0.68 - 1.28) 0.93 (0.67 - 1.29) 0.845

GMCSF 0.67 (0.47 - 0.95) 0.67 (0.47 - 0.95) 0.210

CXCL1/GRO 0.81 (0.59 - 1.12) 0.82 (0.59 - 1.14) 0.593

IL16 1.19 (0.85 - 1.66) 1.16 (0.83 - 1.63) 0.685

IL1RA 0.81 (0.59 - 1.13) 0.79 (0.57 - 1.11) 0.499

IL8 0.85 (0.60 - 1.19) 0.87 (0.61 - 1.23) 0.736

IL10 1.07 (0.74 - 1.54) 1.08 (0.75 - 1.56) 0.845

IL12p70 0.81 (0.57 - 1.17) 0.82 (0.57 - 1.18) 0.606

IL13 0.81 (0.56 - 1.15) 0.81 (0.56 - 1.16) 0.593

IL17A 0.86 (0.60 - 1.22) 0.87 (0.61 - 1.24) 0.736

IL1B 0.67 (0.47 - 0.97) 0.66 (0.45 - 0.96) 0.213

IL21 1.05 (0.72 - 1.53) 1.04 (0.71 - 1.53) 0.910

IL23 0.79 (0.55 - 1.12) 0.78 (0.54 - 1.12) 0.499

IL5 0.70 (0.49 - 1.01) 0.69 (0.48 - 1.00) 0.247

IL6 0.70 (0.48 - 1.03) 0.68 (0.46 - 1.01) 0.268

IL7 1.03 (0.71 - 1.49) 1.04 (0.71 - 1.51) 0.910

IP10 1.17 (0.84 - 1.62) 1.12 (0.80 - 1.56) 0.764

CCL2/MCP1 1.55 (1.12 - 2.16) 1.58 (1.13 - 2.21) 0.096

CCL8/MCP2 1.13 (0.82 - 1.54) 1.11 (0.80 - 1.53) 0.769

CCL13/MCP4 1.36 (0.98 - 1.89) 1.33 (0.95 - 1.86) 0.378

CCL22/MDC 1.01 (0.73 - 1.39) 0.96 (0.69 - 1.34) 0.909

CCL4/MIP1B 1.07 (0.77 - 1.48) 1.03 (0.74 - 1.44) 0.910

CCL15/MIP1D 1.13 (0.81 - 1.56) 1.10 (0.79 - 1.54) 0.778

CCL3/MIP1A 1.03 (0.72 - 1.49) 0.99 (0.68 - 1.45) 0.979

SAA 1.50 (1.09 - 2.06) 1.42 (1.03 - 1.96) 0.213

SAP 2.05 (1.46 - 2.88) 2.08 (1.47 - 2.95) 0.001

SCF 1.45 (1.04 - 2.01) 1.44 (1.03 - 2.02) 0.213

CXCL12/SDF1AB 0.48 (0.34 - 0.66) 0.45 (0.32 - 0.63) < 0.001

SEGFR 1.04 (0.73 - 1.47) 1.12 (0.79 - 1.60) 0.764

SGP130 1.35 (0.95 - 1.91) 1.34 (0.94 - 1.92) 0.421

SIL4R 1.01 (0.71 - 1.44) 0.99 (0.69 - 1.42) 0.975

SIL6R 1.28 (0.90 - 1.80) 1.22 (0.86 - 1.75) 0.606

SILRII 1.19 (0.83 - 1.69) 1.27 (0.88 - 1.83) 0.547

STNFRI 1.25 (0.89 - 1.76) 1.24 (0.87 - 1.76) 0.593

STNFRII 1.28 (0.90 - 1.83) 1.19 (0.83 - 1.71) 0.663

SVEGFR2 1.16 (0.82 - 1.65) 1.17 (0.82 - 1.69) 0.685

SVEGFR3 1.45 (1.01 - 2.07) 1.39 (0.96 - 1.99) 0.337

CCL17/TARC 0.71 (0.51 - 0.97) 0.66 (0.48 - 0.92) 0.152

TGFA 0.83 (0.60 - 1.16) 0.82 (0.58 - 1.15) 0.593

TNFA 1.50 (1.08 - 2.09) 1.49 (1.06 - 2.09) 0.204

TPO 0.96 (0.70 - 1.33) 0.93 (0.67 - 1.29) 0.845

TRAIL 1.61 (1.17 - 2.23) 1.59 (1.14 - 2.22) 0.079

VEGF 1.18 (0.85 - 1.62) 1.22 (0.88 - 1.69) 0.593

ADA 1.01 (0.64 - 1.59) 1.09 (0.68 - 1.74) 0.879

AXIN1 1.12 (0.65 - 1.95) 1.27 (0.72 - 2.25) 0.721

BNGF 1.13 (0.71 - 1.79) 1.17 (0.73 - 1.88) 0.764

4E-BP1 1.11 (0.69 - 1.79) 1.08 (0.66 - 1.76) 0.898

CASP8 1.11 (0.70 - 1.76) 1.13 (0.70 - 1.81) 0.809

CCL23/MIP3 0.66 (0.41 - 1.05) 0.63 (0.39 - 1.02) 0.268

CCL25/TECK 0.92 (0.58 - 1.44) 0.88 (0.55 - 1.40) 0.783

CCL28/MEC 0.44 (0.28 - 0.71) 0.44 (0.27 - 0.71) 0.016

CD244 0.87 (0.55 - 1.38) 0.85 (0.53 - 1.37) 0.764

CD40 1.14 (0.72 - 1.80) 1.15 (0.72 - 1.84) 0.769

CD5 1.86 (1.17 - 2.96) 1.73 (1.07 - 2.79) 0.210

CD6 1.71 (1.07 - 2.73) 1.59 (0.98 - 2.58) 0.272

CDCP1 1.38 (0.86 - 2.23) 1.46 (0.89 - 2.39) 0.493

CSF1 1.08 (0.69 - 1.71) 1.01 (0.63 - 1.62) 0.975

CST5 0.95 (0.61 - 1.48) 0.85 (0.54 - 1.36) 0.764

DNER 0.94 (0.59 - 1.51) 0.96 (0.59 - 1.55) 0.910

ENRAGE 1.10 (0.69 - 1.73) 1.04 (0.65 - 1.68) 0.910

FGF19 0.87 (0.55 - 1.38) 0.92 (0.58 - 1.48) 0.879

FGF21 1.27 (0.80 - 1.99) 1.27 (0.79 - 2.04) 0.631

FGF23 1.39 (0.88 - 2.21) 1.29 (0.80 - 2.07) 0.606

FLT3L 1.20 (0.75 - 1.93) 1.16 (0.71 - 1.90) 0.769

HGF 1.25 (0.78 - 1.99) 1.30 (0.81 - 2.11) 0.606

IL10RB 1.15 (0.72 - 1.83) 1.17 (0.72 - 1.88) 0.764

IL12B 1.57 (0.97 - 2.54) 1.34 (0.82 - 2.20) 0.593

IL18R1 2.36 (1.46 - 3.79) 2.37 (1.45 - 3.87) 0.012

IL18 1.65 (1.04 - 2.63) 1.67 (1.03 - 2.70) 0.226

TGFB1/LAB 1.34 (0.85 - 2.10) 1.29 (0.81 - 2.06) 0.606

LIFR 0.95 (0.59 - 1.53) 0.96 (0.59 - 1.56) 0.910

CCL7/MCP3 1.23 (0.77 - 1.98) 1.29 (0.80 - 2.10) 0.606

MMP1 0.84 (0.53 - 1.32) 0.81 (0.51 - 1.29) 0.685

MMP10 0.85 (0.53 - 1.36) 0.87 (0.54 - 1.42) 0.783

NT3 1.22 (0.74 - 2.02) 1.18 (0.71 - 1.98) 0.764

OPG 0.85 (0.54 - 1.34) 0.85 (0.53 - 1.36) 0.764

OSM 0.51 (0.31 - 0.84) 0.52 (0.31 - 0.88) 0.152

PDL1 1.11 (0.70 - 1.75) 1.05 (0.65 - 1.68) 0.910

SLAMF1 1.42 (0.89 - 2.25) 1.26 (0.78 - 2.02) 0.663

ST1A1 1.11 (0.69 - 1.79) 1.11 (0.68 - 1.81) 0.845

STAMPB 0.95 (0.60 - 1.50) 1.03 (0.64 - 1.65) 0.938

TNFB 1.66 (1.03 - 2.67) 1.47 (0.89 - 2.41) 0.492

TNFRSF9 1.60 (1.00 - 2.57) 1.41 (0.86 - 2.30) 0.499

TNFSF14 0.78 (0.49 - 1.23) 0.80 (0.49 - 1.28) 0.665

TRANCE 2.04 (1.26 - 3.29) 2.02 (1.24 - 3.29) 0.075

TWEAK 0.76 (0.48 - 1.21) 0.70 (0.44 - 1.13) 0.495

UPA 0.78 (0.50 - 1.23) 0.84 (0.53 - 1.34) 0.764

VEGFA 1.36 (0.86 - 2.15) 1.40 (0.88 - 2.25) 0.499

IL29/IFNL1 1.45 (0.95 - 2.20) 1.54 (1.00 - 2.37) 0.247

IL33 0.91 (0.58 - 1.42) 0.94 (0.59 - 1.49) 0.901

IL4 1.09 (0.66 - 1.81) 1.14 (0.68 - 1.90) 0.809

TSLP 0.95 (0.56 - 1.62) 0.93 (0.53 - 1.61) 0.901

IL10RA 0.86 (0.41 - 1.77) 0.76 (0.36 - 1.62) 0.764

IL17C 1.65 (0.79 - 3.44) 1.63 (0.74 - 3.57) 0.593

SIRT2 0.78 (0.36 - 1.69) 0.89 (0.40 - 2.00) 0.901

OR1 is adjusted for age, sex, and study site.

OR2 is further adjusted for smoking (never/past/current), alcohol use (never/<weekly, <150g/week, 150-<300g/week, 300+ g/week), fasting status at

blood draw(<8 hrs/ 8+ hrs), and low PA.

Adjusted P-Values presented for OR2 only, and bold face denotes FDR P-value < 0.05.

Table S3. Associations between low physical activity and marker quantiles.


CCL21/6CKINE 1.15 (0.83 - 1.59) 1.15 (0.83 - 1.61) 0.735

CXCL13/BCA1 1.20 (0.87 - 1.64) 1.20 (0.87 - 1.65) 0.632

CCL19/MIP3B 1.49 (1.09 - 2.04) 1.48 (1.08 - 2.05) 0.239

CCL20/MIP3A 1.03 (0.75 - 1.40) 1.04 (0.76 - 1.43) 0.965

CRP 1.35 (0.98 - 1.85) 1.33 (0.96 - 1.84) 0.523

CCL27/CTACK 1.38 (1.00 - 1.91) 1.46 (1.05 - 2.02) 0.267

CXCL11/ITAC 1.11 (0.81 - 1.51) 1.02 (0.74 - 1.41) 0.965

CXCL6/GCP2 1.16 (0.84 - 1.59) 1.07 (0.77 - 1.47) 0.919

CXCL9/MIG 1.27 (0.92 - 1.75) 1.19 (0.86 - 1.66) 0.662

EGF 0.84 (0.62 - 1.16) 0.84 (0.61 - 1.16) 0.662

CXCL5/ENA78 0.67 (0.48 - 0.92) 0.68 (0.49 - 0.95) 0.267

CCL24/EOTAXIN2 1.03 (0.75 - 1.41) 0.98 (0.71 - 1.36) 0.965

CCL11/EOTAXIN 0.87 (0.64 - 1.20) 0.87 (0.63 - 1.20) 0.735

FGF2 1.51 (1.09 - 2.09) 1.54 (1.11 - 2.14) 0.222


GCSF 0.96 (0.70 - 1.33) 0.97 (0.69 - 1.34) 0.965

GMCSF 1.15 (0.82 - 1.60) 1.17 (0.83 - 1.65) 0.735

CXCL1/GRO 0.86 (0.63 - 1.18) 0.87 (0.63 - 1.20) 0.735

IL16 0.93 (0.68 - 1.29) 0.95 (0.68 - 1.32) 0.951

IL1RA 1.17 (0.85 - 1.61) 1.18 (0.85 - 1.63) 0.714

IL8 0.83 (0.60 - 1.16) 0.82 (0.58 - 1.16) 0.631

IL10 1.28 (0.90 - 1.83) 1.29 (0.90 - 1.86) 0.612

IL12p70 0.98 (0.70 - 1.38) 1.03 (0.73 - 1.45) 0.965

IL13 1.00 (0.71 - 1.41) 1.02 (0.72 - 1.45) 0.965

IL17A 1.01 (0.72 - 1.42) 1.02 (0.73 - 1.44) 0.965

IL1B 1.16 (0.82 - 1.64) 1.19 (0.83 - 1.71) 0.720

IL21 0.99 (0.69 - 1.42) 1.00 (0.69 - 1.45) 0.998

IL23 1.01 (0.72 - 1.43) 1.05 (0.74 - 1.49) 0.965

IL5 0.86 (0.61 - 1.21) 0.87 (0.62 - 1.24) 0.763

IL6 1.19 (0.83 - 1.69) 1.27 (0.89 - 1.83) 0.612

IL7 0.89 (0.63 - 1.26) 0.93 (0.66 - 1.33) 0.919

IP10 1.13 (0.82 - 1.54) 1.13 (0.81 - 1.56) 0.790

CCL2/MCP1 1.45 (1.06 - 1.99) 1.36 (0.98 - 1.88) 0.445

CCL8/MCP2 1.00 (0.73 - 1.37) 0.97 (0.70 - 1.33) 0.965

CCL13/MCP4 1.06 (0.76 - 1.48) 1.04 (0.74 - 1.46) 0.965

CCL22/MDC 0.95 (0.69 - 1.31) 0.98 (0.71 - 1.36) 0.965

CCL4/MIP1B 1.06 (0.77 - 1.46) 0.99 (0.71 - 1.39) 0.998

CCL15/MIP1D 1.14 (0.83 - 1.56) 1.17 (0.84 - 1.61) 0.730

CCL3/MIP1A 1.03 (0.73 - 1.47) 0.99 (0.69 - 1.43) 0.998

SAA 1.27 (0.93 - 1.73) 1.31 (0.95 - 1.80) 0.527

SAP 1.37 (0.99 - 1.90) 1.34 (0.96 - 1.87) 0.523

SCF 1.45 (1.05 - 1.99) 1.49 (1.07 - 2.06) 0.239

CXCL12/SDF1AB 1.21 (0.88 - 1.66) 1.23 (0.89 - 1.70) 0.612

SEGFR 1.15 (0.82 - 1.62) 1.16 (0.82 - 1.65) 0.735

SGP130 1.56 (1.11 - 2.18) 1.57 (1.11 - 2.21) 0.222

SIL4R 1.08 (0.77 - 1.52) 1.09 (0.78 - 1.54) 0.891

SIL6R 1.76 (1.24 - 2.49) 1.77 (1.24 - 2.52) 0.092

SILRII 0.86 (0.61 - 1.22) 0.91 (0.64 - 1.29) 0.879

STNFRI 1.05 (0.75 - 1.48) 1.00 (0.71 - 1.41) 0.998

STNFRII 1.51 (1.07 - 2.14) 1.45 (1.01 - 2.06) 0.377

SVEGFR2 1.21 (0.86 - 1.69) 1.27 (0.90 - 1.80) 0.612

SVEGFR3 1.20 (0.85 - 1.69) 1.16 (0.82 - 1.64) 0.735

CCL17/TARC 0.81 (0.59 - 1.11) 0.82 (0.59 - 1.13) 0.612

TGFA 1.06 (0.77 - 1.47) 1.07 (0.77 - 1.49) 0.919

TNFA 1.15 (0.84 - 1.59) 1.07 (0.77 - 1.49) 0.919

TPO 1.36 (1.00 - 1.87) 1.39 (1.01 - 1.91) 0.377

TRAIL 1.16 (0.84 - 1.60) 1.16 (0.84 - 1.61) 0.735

VEGF 0.89 (0.65 - 1.22) 0.88 (0.63 - 1.22) 0.763

ADA 0.75 (0.49 - 1.16) 0.75 (0.48 - 1.17) 0.612

AXIN1 0.69 (0.41 - 1.16) 0.64 (0.37 - 1.09) 0.541

BNGF 1.02 (0.67 - 1.56) 0.96 (0.62 - 1.49) 0.965

4E-BP1 0.96 (0.60 - 1.53) 0.96 (0.60 - 1.54) 0.965

CASP8 1.06 (0.67 - 1.67) 1.06 (0.66 - 1.70) 0.965

CCL23/MIP3 1.16 (0.75 - 1.78) 1.22 (0.78 - 1.89) 0.735

CCL25/TECK 1.19 (0.77 - 1.84) 1.35 (0.86 - 2.11) 0.612

CCL28/MEC 0.89 (0.58 - 1.36) 0.98 (0.63 - 1.52) 0.965

CD244 1.30 (0.84 - 2.01) 1.35 (0.86 - 2.10) 0.612

CD40 1.10 (0.71 - 1.69) 1.09 (0.70 - 1.70) 0.919

CD5 1.79 (1.15 - 2.80) 1.92 (1.22 - 3.03) 0.180

CD6 1.33 (0.86 - 2.08) 1.35 (0.86 - 2.13) 0.612

CDCP1 1.14 (0.73 - 1.79) 1.09 (0.69 - 1.73) 0.919

CSF1 1.28 (0.83 - 1.98) 1.36 (0.87 - 2.11) 0.612

CST5 0.94 (0.61 - 1.46) 0.97 (0.63 - 1.51) 0.965

DNER 0.71 (0.46 - 1.09) 0.75 (0.48 - 1.16) 0.612

ENRAGE 1.32 (0.85 - 2.05) 1.41 (0.90 - 2.21) 0.584

FGF19 1.02 (0.66 - 1.58) 1.07 (0.68 - 1.68) 0.952

FGF21 1.06 (0.69 - 1.63) 1.17 (0.75 - 1.82) 0.803

FGF23 1.35 (0.87 - 2.07) 1.32 (0.85 - 2.06) 0.612

FLT3L 1.45 (0.93 - 2.25) 1.53 (0.97 - 2.42) 0.445

HGF 1.29 (0.82 - 2.01) 1.33 (0.84 - 2.10) 0.612

IL10RB 1.56 (1.00 - 2.43) 1.52 (0.97 - 2.39) 0.445

IL12B 2.16 (1.38 - 3.38) 2.22 (1.40 - 3.52) 0.081

IL18R1 1.28 (0.83 - 1.96) 1.28 (0.82 - 1.98) 0.648

IL18 1.35 (0.87 - 2.10) 1.36 (0.87 - 2.14) 0.612

TGFB1/LAB 1.25 (0.80 - 1.96) 1.20 (0.75 - 1.90) 0.763

LIFR 1.25 (0.81 - 1.93) 1.31 (0.84 - 2.04) 0.612

CCL7/MCP3 1.11 (0.71 - 1.73) 1.10 (0.69 - 1.73) 0.919

MMP1 0.78 (0.50 - 1.21) 0.85 (0.55 - 1.34) 0.803

MMP10 0.89 (0.58 - 1.37) 0.88 (0.56 - 1.37) 0.864

NT3 0.93 (0.57 - 1.52) 0.90 (0.54 - 1.48) 0.919

OPG 0.98 (0.63 - 1.54) 1.10 (0.69 - 1.74) 0.919

OSM 0.83 (0.52 - 1.30) 0.84 (0.53 - 1.33) 0.763

PDL1 1.39 (0.89 - 2.16) 1.41 (0.90 - 2.22) 0.584

SLAMF1 1.00 (0.65 - 1.52) 1.05 (0.68 - 1.62) 0.965

ST1A1 0.89 (0.57 - 1.39) 0.92 (0.58 - 1.45) 0.919

STAMPB 0.80 (0.52 - 1.24) 0.77 (0.49 - 1.19) 0.612

TNFB 1.76 (1.12 - 2.76) 1.75 (1.10 - 2.78) 0.239

TNFRSF9 1.42 (0.91 - 2.21) 1.45 (0.92 - 2.30) 0.558

TNFSF14 0.82 (0.53 - 1.28) 0.88 (0.56 - 1.38) 0.864

TRANCE 1.34 (0.87 - 2.08) 1.29 (0.83 - 2.01) 0.631

TWEAK 1.58 (1.02 - 2.45) 1.61 (1.02 - 2.52) 0.377

UPA 0.97 (0.63 - 1.50) 0.92 (0.59 - 1.44) 0.919

VEGFA 1.35 (0.88 - 2.06) 1.35 (0.87 - 2.10) 0.612

IL29/IFNL1 0.88 (0.57 - 1.37) 0.87 (0.56 - 1.37) 0.864

IL33 1.44 (0.94 - 2.20) 1.50 (0.97 - 2.32) 0.445

IL4 1.25 (0.75 - 2.08) 1.29 (0.76 - 2.17) 0.723

TSLP 0.83 (0.49 - 1.41) 0.85 (0.49 - 1.46) 0.864

IL10RA 1.18 (0.62 - 2.27) 1.20 (0.61 - 2.36) 0.879

IL17C 0.66 (0.30 - 1.41) 0.61 (0.27 - 1.36) 0.612

SIRT2 0.60 (0.30 - 1.20) 0.57 (0.28 - 1.18) 0.584



blood draw(<8 hrs/ 8+ hrs), and MetS.


Table S4. Associations between obesity (BMI> 25 kg/m2) and marker quantiles.


CCL21/6CKINE 1.16 (0.87 - 1.56) 1.15 (0.86 - 1.55) 0.675

CXCL13/BCA1 1.45 (1.09 - 1.94) 1.47 (1.10 - 1.98) 0.101

CCL19/MIP3B 1.87 (1.40 - 2.50) 1.91 (1.42 - 2.57) 0.001

CCL20/MIP3A 0.97 (0.72 - 1.30) 0.95 (0.71 - 1.28) 0.917

CRP 2.11 (1.58 - 2.82) 2.16 (1.61 - 2.90) < 0.001

CCL27/CTACK 0.85 (0.64 - 1.13) 0.83 (0.62 - 1.12) 0.621

CXCL11/ITAC 1.34 (1.00 - 1.78) 1.36 (1.01 - 1.81) 0.230

CXCL6/GCP2 1.21 (0.90 - 1.63) 1.14 (0.84 - 1.54) 0.704

CXCL9/MIG 1.13 (0.84 - 1.52) 1.15 (0.85 - 1.55) 0.683

EGF 0.92 (0.69 - 1.22) 0.96 (0.71 - 1.28) 0.917

CXCL5/ENA78 0.94 (0.71 - 1.25) 0.96 (0.71 - 1.28) 0.917

CCL24/EOTAXIN2 1.09 (0.81 - 1.45) 1.12 (0.84 - 1.50) 0.750

CCL11/EOTAXIN 0.85 (0.63 - 1.14) 0.86 (0.64 - 1.16) 0.652

FGF2 0.93 (0.70 - 1.24) 0.95 (0.71 - 1.27) 0.917


GCSF 0.82 (0.62 - 1.09) 0.81 (0.61 - 1.08) 0.513

GMCSF 0.85 (0.62 - 1.15) 0.84 (0.62 - 1.15) 0.633

CXCL1/GRO 0.73 (0.55 - 0.97) 0.72 (0.54 - 0.97) 0.207

IL16 0.93 (0.70 - 1.25) 0.91 (0.68 - 1.23) 0.828

IL1RA 0.98 (0.74 - 1.30) 0.99 (0.74 - 1.32) 0.978

IL8 0.73 (0.54 - 0.99) 0.74 (0.54 - 1.01) 0.247

IL10 1.04 (0.76 - 1.42) 1.06 (0.77 - 1.47) 0.917

IL12p70 1.06 (0.78 - 1.46) 1.05 (0.76 - 1.45) 0.917

IL13 0.92 (0.67 - 1.26) 0.87 (0.63 - 1.20) 0.706

IL17A 1.10 (0.81 - 1.49) 1.08 (0.79 - 1.47) 0.917

IL1B 0.84 (0.61 - 1.15) 0.83 (0.60 - 1.14) 0.621

IL21 1.21 (0.87 - 1.68) 1.22 (0.87 - 1.70) 0.621

IL23 0.97 (0.71 - 1.32) 0.95 (0.69 - 1.30) 0.917

IL5 0.97 (0.71 - 1.32) 0.90 (0.66 - 1.24) 0.822

IL6 0.96 (0.70 - 1.32) 0.96 (0.69 - 1.32) 0.917

IL7 1.03 (0.75 - 1.42) 1.00 (0.72 - 1.39) 0.991

IP10 1.44 (1.08 - 1.92) 1.48 (1.10 - 1.99) 0.101

CCL2/MCP1 1.37 (1.02 - 1.84) 1.44 (1.07 - 1.94) 0.165

CCL8/MCP2 1.03 (0.77 - 1.37) 1.10 (0.82 - 1.47) 0.822

CCL13/MCP4 0.99 (0.74 - 1.33) 1.00 (0.74 - 1.35) 0.996

CCL22/MDC 0.96 (0.72 - 1.29) 1.02 (0.76 - 1.37) 0.973

CCL4/MIP1B 1.02 (0.76 - 1.37) 1.06 (0.79 - 1.43) 0.917

CCL15/MIP1D 1.06 (0.79 - 1.40) 1.03 (0.77 - 1.38) 0.930

CCL3/MIP1A 1.08 (0.78 - 1.49) 1.07 (0.77 - 1.49) 0.917

SAA 1.65 (1.23 - 2.20) 1.64 (1.22 - 2.20) 0.015

SAP 1.28 (0.95 - 1.73) 1.41 (1.04 - 1.91) 0.195

SCF 1.17 (0.88 - 1.56) 1.17 (0.87 - 1.57) 0.639

CXCL12/SDF1AB 0.70 (0.53 - 0.94) 0.73 (0.55 - 0.98) 0.217

SEGFR 0.89 (0.65 - 1.21) 0.95 (0.69 - 1.31) 0.917

SGP130 1.12 (0.82 - 1.53) 1.13 (0.82 - 1.56) 0.759

SIL4R 1.04 (0.76 - 1.42) 1.06 (0.77 - 1.46) 0.917

SIL6R 0.93 (0.68 - 1.27) 0.93 (0.68 - 1.28) 0.917

SILRII 1.29 (0.94 - 1.76) 1.39 (1.01 - 1.92) 0.230

STNFRI 1.28 (0.94 - 1.75) 1.33 (0.97 - 1.83) 0.315

STNFRII 1.09 (0.79 - 1.49) 1.07 (0.77 - 1.48) 0.917

SVEGFR2 1.14 (0.83 - 1.57) 1.20 (0.87 - 1.67) 0.621

SVEGFR3 1.08 (0.79 - 1.48) 1.05 (0.76 - 1.45) 0.917

CCL17/TARC 0.89 (0.66 - 1.19) 0.87 (0.64 - 1.17) 0.675

TGFA 0.87 (0.65 - 1.16) 0.88 (0.65 - 1.18) 0.704

TNFA 1.27 (0.95 - 1.71) 1.31 (0.97 - 1.77) 0.315

TPO 0.73 (0.55 - 0.98) 0.75 (0.56 - 1.01) 0.247

TRAIL 1.78 (1.33 - 2.38) 1.80 (1.34 - 2.42) 0.002

VEGF 1.02 (0.77 - 1.37) 1.02 (0.76 - 1.37) 0.973

ADA 1.54 (1.03 - 2.30) 1.50 (1.00 - 2.26) 0.244

AXIN1 0.99 (0.60 - 1.63) 0.97 (0.58 - 1.61) 0.973

BNGF 0.64 (0.42 - 0.96) 0.61 (0.41 - 0.93) 0.193

4E-BP1 1.31 (0.86 - 2.01) 1.34 (0.87 - 2.07) 0.568

CASP8 1.27 (0.85 - 1.92) 1.30 (0.86 - 1.98) 0.621

CCL23/MIP3 0.76 (0.50 - 1.16) 0.75 (0.49 - 1.14) 0.568

CCL25/TECK 0.97 (0.65 - 1.46) 1.02 (0.67 - 1.53) 0.978

CCL28/MEC 0.51 (0.34 - 0.77) 0.47 (0.31 - 0.72) 0.010

CD244 0.92 (0.61 - 1.39) 0.91 (0.60 - 1.38) 0.917

CD40 1.17 (0.79 - 1.75) 1.21 (0.80 - 1.81) 0.683

CD5 1.39 (0.92 - 2.10) 1.45 (0.96 - 2.20) 0.315

CD6 1.53 (1.00 - 2.33) 1.53 (1.00 - 2.35) 0.244

CDCP1 0.76 (0.50 - 1.17) 0.80 (0.52 - 1.23) 0.639

CSF1 1.30 (0.86 - 1.96) 1.25 (0.83 - 1.89) 0.639

CST5 0.84 (0.56 - 1.26) 0.79 (0.52 - 1.19) 0.621

DNER 1.07 (0.71 - 1.62) 1.07 (0.70 - 1.63) 0.917

ENRAGE 0.96 (0.64 - 1.43) 0.95 (0.63 - 1.43) 0.917

FGF19 0.71 (0.47 - 1.09) 0.71 (0.46 - 1.08) 0.399

FGF21 0.89 (0.60 - 1.33) 0.94 (0.63 - 1.42) 0.917

FGF23 1.23 (0.82 - 1.86) 1.09 (0.72 - 1.65) 0.917

FLT3L 2.00 (1.30 - 3.08) 2.05 (1.32 - 3.18) 0.019

HGF 1.31 (0.86 - 1.98) 1.40 (0.92 - 2.13) 0.419

IL10RB 1.07 (0.71 - 1.60) 1.13 (0.75 - 1.71) 0.845

IL12B 1.68 (1.09 - 2.57) 1.66 (1.07 - 2.56) 0.195

IL18R1 2.35 (1.56 - 3.56) 2.34 (1.54 - 3.54) 0.002

IL18 1.49 (0.99 - 2.26) 1.62 (1.06 - 2.46) 0.195

TGFB1/LAB 1.16 (0.77 - 1.74) 1.17 (0.77 - 1.77) 0.759

LIFR 1.11 (0.74 - 1.65) 1.19 (0.79 - 1.79) 0.709

CCL7/MCP3 1.96 (1.30 - 2.97) 2.10 (1.38 - 3.19) 0.010

MMP1 0.71 (0.47 - 1.06) 0.69 (0.46 - 1.05) 0.318

MMP10 0.64 (0.42 - 0.96) 0.65 (0.43 - 0.99) 0.230

NT3 1.32 (0.84 - 2.07) 1.27 (0.80 - 2.00) 0.639

OPG 0.77 (0.51 - 1.16) 0.77 (0.51 - 1.17) 0.621

OSM 0.77 (0.49 - 1.19) 0.78 (0.50 - 1.21) 0.631

PDL1 0.90 (0.60 - 1.36) 0.96 (0.63 - 1.45) 0.930

SLAMF1 1.04 (0.69 - 1.56) 0.98 (0.65 - 1.48) 0.978

ST1A1 1.07 (0.70 - 1.63) 1.05 (0.68 - 1.61) 0.930

STAMPB 1.02 (0.68 - 1.54) 1.04 (0.68 - 1.56) 0.966

TNFB 1.36 (0.88 - 2.10) 1.37 (0.89 - 2.13) 0.519

TNFRSF9 1.22 (0.81 - 1.85) 1.24 (0.82 - 1.89) 0.639

TNFSF14 0.75 (0.49 - 1.14) 0.76 (0.50 - 1.16) 0.621

TRANCE 1.23 (0.82 - 1.85) 1.27 (0.84 - 1.92) 0.621

TWEAK 0.86 (0.57 - 1.31) 0.87 (0.57 - 1.32) 0.808

UPA 0.81 (0.54 - 1.21) 0.81 (0.53 - 1.22) 0.642

VEGFA 0.97 (0.65 - 1.46) 1.02 (0.68 - 1.54) 0.973

IL29/IFNL1 1.11 (0.75 - 1.64) 1.15 (0.77 - 1.71) 0.808

IL33 0.97 (0.65 - 1.45) 1.00 (0.66 - 1.50) 0.991

IL4 1.31 (0.84 - 2.02) 1.32 (0.84 - 2.07) 0.621

TSLP 1.37 (0.87 - 2.16) 1.32 (0.83 - 2.10) 0.621

IL10RA 1.17 (0.62 - 2.20) 1.14 (0.59 - 2.18) 0.917

IL17C 0.47 (0.20 - 1.10) 0.39 (0.16 - 0.94) 0.219

SIRT2 0.66 (0.32 - 1.35) 0.72 (0.34 - 1.49) 0.684





Table S5. Associations between low HDL and marker quantiles.


CCL21/6CKINE 1.48 (1.09 - 2.00) 1.46 (1.07 - 1.99) 0.101

CXCL13/BCA1 1.56 (1.15 - 2.11) 1.59 (1.16 - 2.17) 0.031

CCL19/MIP3B 1.99 (1.48 - 2.70) 1.83 (1.34 - 2.49) 0.005

CCL20/MIP3A 1.61 (1.19 - 2.18) 1.60 (1.17 - 2.18) 0.029

CRP 2.28 (1.68 - 3.10) 2.14 (1.56 - 2.93) < 0.001

CCL27/CTACK 0.98 (0.73 - 1.33) 0.89 (0.65 - 1.21) 0.642

CXCL11/ITAC 1.40 (1.04 - 1.87) 1.40 (1.03 - 1.90) 0.152

CXCL6/GCP2 1.70 (1.25 - 2.30) 1.78 (1.30 - 2.43) 0.008

CXCL9/MIG 1.75 (1.29 - 2.39) 1.76 (1.28 - 2.41) 0.009

EGF 1.19 (0.88 - 1.62) 1.34 (0.98 - 1.83) 0.227

CXCL5/ENA78 1.26 (0.94 - 1.71) 1.31 (0.97 - 1.79) 0.238

CCL24/EOTAXIN2 0.92 (0.68 - 1.23) 0.91 (0.67 - 1.24) 0.718

CCL11/EOTAXIN 0.94 (0.69 - 1.27) 0.86 (0.63 - 1.18) 0.552

FGF2 1.00 (0.74 - 1.35) 0.96 (0.71 - 1.31) 0.851


GCSF 1.01 (0.75 - 1.36) 1.03 (0.76 - 1.40) 0.884

GMCSF 0.93 (0.67 - 1.29) 0.91 (0.65 - 1.27) 0.720

CXCL1/GRO 1.26 (0.94 - 1.70) 1.35 (0.99 - 1.83) 0.221

IL16 1.12 (0.83 - 1.53) 1.18 (0.86 - 1.61) 0.520

IL1RA 0.87 (0.64 - 1.17) 0.86 (0.63 - 1.18) 0.550

IL8 1.09 (0.79 - 1.49) 1.15 (0.83 - 1.59) 0.607

IL10 1.25 (0.89 - 1.76) 1.23 (0.87 - 1.74) 0.466

IL12p70 1.15 (0.83 - 1.59) 1.14 (0.82 - 1.60) 0.632

IL13 1.14 (0.82 - 1.58) 1.15 (0.82 - 1.61) 0.607

IL17A 1.19 (0.85 - 1.65) 1.13 (0.81 - 1.58) 0.663

IL1B 1.14 (0.82 - 1.60) 1.12 (0.79 - 1.58) 0.718

IL21 1.48 (1.04 - 2.09) 1.42 (1.00 - 2.02) 0.214

IL23 1.39 (1.00 - 1.94) 1.31 (0.94 - 1.84) 0.324

IL5 1.14 (0.82 - 1.58) 1.11 (0.79 - 1.55) 0.718

IL6 1.20 (0.85 - 1.69) 1.15 (0.81 - 1.64) 0.632

IL7 1.02 (0.72 - 1.43) 0.99 (0.70 - 1.40) 0.965

IP10 1.28 (0.95 - 1.74) 1.33 (0.97 - 1.82) 0.236

CCL2/MCP1 1.81 (1.33 - 2.46) 1.77 (1.29 - 2.43) 0.008

CCL8/MCP2 1.21 (0.90 - 1.62) 1.21 (0.89 - 1.64) 0.452

CCL13/MCP4 1.27 (0.93 - 1.72) 1.22 (0.90 - 1.67) 0.447

CCL22/MDC 1.26 (0.94 - 1.71) 1.18 (0.86 - 1.61) 0.520

CCL4/MIP1B 1.28 (0.94 - 1.74) 1.29 (0.94 - 1.77) 0.324

CCL15/MIP1D 1.33 (0.98 - 1.79) 1.32 (0.97 - 1.80) 0.238

CCL3/MIP1A 1.23 (0.87 - 1.74) 1.29 (0.90 - 1.84) 0.377

SAA 1.23 (0.92 - 1.65) 1.16 (0.86 - 1.56) 0.550

SAP 1.34 (0.98 - 1.83) 1.41 (1.03 - 1.95) 0.158

SCF 1.66 (1.23 - 2.25) 1.64 (1.20 - 2.24) 0.022

CXCL12/SDF1AB 0.52 (0.38 - 0.71) 0.48 (0.35 - 0.66) < 0.001

SEGFR 0.80 (0.58 - 1.10) 0.86 (0.62 - 1.19) 0.554

SGP130 1.11 (0.80 - 1.53) 1.10 (0.79 - 1.54) 0.718

SIL4R 1.22 (0.88 - 1.70) 1.21 (0.87 - 1.70) 0.478

SIL6R 1.37 (1.00 - 1.90) 1.29 (0.92 - 1.80) 0.343

SILRII 0.85 (0.61 - 1.17) 0.92 (0.66 - 1.29) 0.748

STNFRI 1.35 (0.97 - 1.86) 1.30 (0.93 - 1.81) 0.330

STNFRII 1.93 (1.38 - 2.70) 1.73 (1.22 - 2.44) 0.022

SVEGFR2 1.03 (0.74 - 1.42) 1.08 (0.77 - 1.51) 0.758

SVEGFR3 1.58 (1.14 - 2.19) 1.58 (1.13 - 2.20) 0.060

CCL17/TARC 0.89 (0.66 - 1.20) 0.83 (0.61 - 1.13) 0.459

TGFA 1.11 (0.81 - 1.51) 1.10 (0.80 - 1.51) 0.718

TNFA 1.42 (1.04 - 1.93) 1.38 (1.00 - 1.90) 0.200

TPO 1.28 (0.95 - 1.72) 1.18 (0.87 - 1.61) 0.508

TRAIL 1.20 (0.89 - 1.63) 1.17 (0.85 - 1.59) 0.546

VEGF 1.24 (0.92 - 1.68) 1.22 (0.89 - 1.66) 0.447

ADA 0.81 (0.54 - 1.23) 0.95 (0.62 - 1.45) 0.851

AXIN1 1.15 (0.70 - 1.88) 1.40 (0.84 - 2.34) 0.432

BNGF 1.13 (0.75 - 1.71) 1.12 (0.74 - 1.72) 0.720

4E-BP1 1.07 (0.70 - 1.65) 1.13 (0.73 - 1.75) 0.720

CASP8 1.04 (0.68 - 1.60) 1.10 (0.71 - 1.71) 0.758

CCL23/MIP3 1.19 (0.78 - 1.81) 1.13 (0.74 - 1.74) 0.720

CCL25/TECK 1.06 (0.70 - 1.60) 1.01 (0.66 - 1.55) 0.968

CCL28/MEC 0.59 (0.39 - 0.90) 0.59 (0.38 - 0.91) 0.101

CD244 0.92 (0.61 - 1.39) 0.96 (0.63 - 1.47) 0.889

CD40 1.24 (0.82 - 1.88) 1.28 (0.84 - 1.96) 0.476

CD5 2.03 (1.34 - 3.10) 1.93 (1.25 - 2.97) 0.028

CD6 1.45 (0.95 - 2.22) 1.50 (0.97 - 2.32) 0.227

CDCP1 1.29 (0.84 - 1.99) 1.33 (0.85 - 2.07) 0.447

CSF1 1.43 (0.94 - 2.16) 1.38 (0.90 - 2.11) 0.348

CST5 1.06 (0.70 - 1.61) 1.08 (0.70 - 1.66) 0.804

DNER 0.62 (0.41 - 0.94) 0.67 (0.44 - 1.02) 0.227

ENRAGE 1.33 (0.87 - 2.02) 1.30 (0.84 - 2.02) 0.459

FGF19 0.90 (0.59 - 1.36) 0.95 (0.62 - 1.45) 0.851

FGF21 1.34 (0.89 - 2.01) 1.55 (1.02 - 2.37) 0.184

FGF23 1.12 (0.74 - 1.71) 1.07 (0.70 - 1.63) 0.837

FLT3L 0.77 (0.50 - 1.17) 0.79 (0.51 - 1.22) 0.508

HGF 1.64 (1.07 - 2.52) 1.67 (1.08 - 2.60) 0.117

IL10RB 1.33 (0.87 - 2.04) 1.35 (0.87 - 2.08) 0.419

IL12B 1.57 (1.03 - 2.40) 1.62 (1.04 - 2.53) 0.158

IL18R1 1.29 (0.86 - 1.94) 1.26 (0.83 - 1.92) 0.506

IL18 2.16 (1.41 - 3.32) 2.13 (1.36 - 3.32) 0.014

TGFB1/LAB 1.32 (0.87 - 1.99) 1.39 (0.91 - 2.12) 0.330

LIFR 0.81 (0.54 - 1.24) 0.88 (0.57 - 1.35) 0.718

CCL7/MCP3 1.27 (0.83 - 1.94) 1.32 (0.86 - 2.03) 0.447

MMP1 1.00 (0.66 - 1.52) 1.08 (0.70 - 1.66) 0.804

MMP10 0.98 (0.65 - 1.47) 0.89 (0.58 - 1.37) 0.725

NT3 1.02 (0.64 - 1.62) 0.98 (0.61 - 1.58) 0.965

OPG 0.80 (0.53 - 1.23) 0.84 (0.54 - 1.30) 0.632

OSM 1.21 (0.78 - 1.88) 1.28 (0.81 - 2.02) 0.512

PDL1 1.44 (0.95 - 2.18) 1.36 (0.89 - 2.08) 0.377

SLAMF1 1.61 (1.06 - 2.42) 1.60 (1.05 - 2.44) 0.149

ST1A1 1.04 (0.68 - 1.60) 1.18 (0.75 - 1.84) 0.658

STAMPB 1.03 (0.68 - 1.56) 1.12 (0.73 - 1.71) 0.721

TNFB 1.72 (1.13 - 2.64) 1.51 (0.97 - 2.34) 0.227

TNFRSF9 2.00 (1.32 - 3.04) 1.77 (1.15 - 2.72) 0.070

TNFSF14 1.44 (0.94 - 2.21) 1.53 (0.99 - 2.37) 0.221

TRANCE 1.74 (1.15 - 2.65) 1.71 (1.11 - 2.62) 0.096

TWEAK 0.69 (0.46 - 1.06) 0.68 (0.44 - 1.05) 0.238

UPA 1.01 (0.67 - 1.52) 1.01 (0.66 - 1.54) 0.976

VEGFA 1.69 (1.11 - 2.55) 1.67 (1.09 - 2.55) 0.101

IL29/IFNL1 1.22 (0.81 - 1.82) 1.22 (0.81 - 1.86) 0.549

IL33 1.18 (0.79 - 1.77) 1.10 (0.72 - 1.66) 0.758

IL4 2.01 (1.28 - 3.15) 2.09 (1.31 - 3.34) 0.022

TSLP 0.99 (0.61 - 1.61) 0.91 (0.55 - 1.52) 0.804

IL10RA 1.03 (0.55 - 1.93) 0.87 (0.45 - 1.67) 0.758

IL17C 1.61 (0.81 - 3.19) 1.57 (0.76 - 3.23) 0.452

SIRT2 1.38 (0.73 - 2.63) 1.70 (0.87 - 3.33) 0.325





Table S6. Associations between hypertriglyceridemia and marker quantiles


CCL21/6CKINE 0.93 (0.68 - 1.26) 0.93 (0.68 - 1.27) 0.789

CXCL13/BCA1 1.26 (0.94 - 1.70) 1.31 (0.97 - 1.77) 0.224

CCL19/MIP3B 1.88 (1.38 - 2.55) 1.88 (1.38 - 2.56) 0.002

CCL20/MIP3A 1.19 (0.88 - 1.61) 1.20 (0.88 - 1.63) 0.442

CRP 1.79 (1.32 - 2.44) 1.75 (1.29 - 2.39) 0.006

CCL27/CTACK 1.09 (0.81 - 1.48) 1.09 (0.81 - 1.49) 0.770

CXCL11/ITAC 1.03 (0.77 - 1.39) 1.06 (0.79 - 1.44) 0.797

CXCL6/GCP2 1.24 (0.92 - 1.69) 1.24 (0.91 - 1.69) 0.340

CXCL9/MIG 1.06 (0.78 - 1.44) 1.04 (0.76 - 1.43) 0.866

EGF 1.35 (0.99 - 1.82) 1.43 (1.05 - 1.94) 0.094

CXCL5/ENA78 1.19 (0.88 - 1.61) 1.30 (0.96 - 1.77) 0.224

CCL24/EOTAXIN2 0.94 (0.69 - 1.27) 0.95 (0.70 - 1.30) 0.848

CCL11/EOTAXIN 1.03 (0.76 - 1.40) 1.08 (0.79 - 1.48) 0.789

FGF2 0.85 (0.63 - 1.15) 0.82 (0.60 - 1.12) 0.408


GCSF 0.99 (0.73 - 1.34) 1.00 (0.74 - 1.35) 0.986

GMCSF 0.76 (0.54 - 1.06) 0.74 (0.53 - 1.04) 0.224

CXCL1/GRO 0.99 (0.74 - 1.34) 1.02 (0.76 - 1.38) 0.931

IL16 1.41 (1.04 - 1.92) 1.39 (1.02 - 1.91) 0.133

IL1RA 0.77 (0.57 - 1.05) 0.76 (0.56 - 1.04) 0.224

IL8 1.02 (0.74 - 1.39) 1.06 (0.77 - 1.45) 0.833

IL10 1.01 (0.72 - 1.42) 1.03 (0.73 - 1.46) 0.931

IL12p70 0.66 (0.47 - 0.92) 0.66 (0.47 - 0.93) 0.069

IL13 0.61 (0.44 - 0.86) 0.60 (0.43 - 0.85) 0.022

IL17A 0.63 (0.46 - 0.88) 0.63 (0.45 - 0.88) 0.033

IL1B 0.63 (0.44 - 0.89) 0.60 (0.42 - 0.86) 0.027

IL21 0.86 (0.60 - 1.23) 0.86 (0.60 - 1.23) 0.640

IL23 0.69 (0.49 - 0.96) 0.68 (0.49 - 0.96) 0.109

IL5 0.56 (0.40 - 0.78) 0.56 (0.39 - 0.78) 0.008

IL6 0.69 (0.48 - 0.98) 0.68 (0.47 - 0.98) 0.140

IL7 0.89 (0.63 - 1.26) 0.87 (0.61 - 1.23) 0.665

IP10 1.06 (0.78 - 1.43) 1.11 (0.82 - 1.51) 0.717

CCL2/MCP1 1.61 (1.19 - 2.19) 1.62 (1.19 - 2.21) 0.015

CCL8/MCP2 0.87 (0.64 - 1.17) 0.88 (0.65 - 1.18) 0.621

CCL13/MCP4 1.06 (0.78 - 1.44) 1.10 (0.80 - 1.50) 0.770

CCL22/MDC 1.03 (0.76 - 1.38) 1.07 (0.79 - 1.45) 0.792

CCL4/MIP1B 1.20 (0.89 - 1.64) 1.20 (0.88 - 1.65) 0.442

CCL15/MIP1D 1.34 (0.99 - 1.81) 1.31 (0.97 - 1.78) 0.224

CCL3/MIP1A 1.01 (0.72 - 1.44) 1.01 (0.71 - 1.43) 0.982

SAA 1.45 (1.08 - 1.95) 1.46 (1.08 - 1.97) 0.057

SAP 2.45 (1.79 - 3.37) 2.39 (1.73 - 3.29) < 0.001

SCF 1.54 (1.13 - 2.09) 1.55 (1.13 - 2.11) 0.032

CXCL12/SDF1AB 0.43 (0.32 - 0.58) 0.42 (0.31 - 0.57) < 0.001

SEGFR 1.19 (0.87 - 1.64) 1.19 (0.86 - 1.64) 0.495

SGP130 1.23 (0.89 - 1.71) 1.21 (0.87 - 1.67) 0.461

SIL4R 0.89 (0.64 - 1.23) 0.89 (0.64 - 1.23) 0.717

SIL6R 1.73 (1.25 - 2.40) 1.71 (1.22 - 2.38) 0.013

SILRII 1.24 (0.89 - 1.73) 1.25 (0.89 - 1.74) 0.376

STNFRI 1.55 (1.12 - 2.14) 1.57 (1.13 - 2.19) 0.033

STNFRII 1.32 (0.95 - 1.83) 1.33 (0.96 - 1.86) 0.224

SVEGFR2 1.34 (0.96 - 1.85) 1.34 (0.96 - 1.86) 0.224

SVEGFR3 1.83 (1.31 - 2.55) 1.80 (1.29 - 2.52) 0.007

CCL17/TARC 0.57 (0.42 - 0.77) 0.58 (0.43 - 0.79) 0.006

TGFA 1.06 (0.78 - 1.44) 1.07 (0.78 - 1.46) 0.795

TNFA 1.28 (0.95 - 1.74) 1.30 (0.95 - 1.77) 0.229

TPO 0.99 (0.73 - 1.34) 0.99 (0.73 - 1.34) 0.974

TRAIL 1.76 (1.30 - 2.37) 1.78 (1.31 - 2.42) 0.005

VEGF 0.94 (0.70 - 1.27) 0.96 (0.71 - 1.30) 0.862

ADA 1.07 (0.70 - 1.66) 1.10 (0.71 - 1.71) 0.791

AXIN1 1.32 (0.80 - 2.19) 1.41 (0.84 - 2.36) 0.372

BNGF 1.15 (0.74 - 1.78) 1.12 (0.72 - 1.74) 0.789

4E-BP1 0.94 (0.59 - 1.48) 0.97 (0.61 - 1.54) 0.931

CASP8 1.78 (1.13 - 2.81) 1.78 (1.12 - 2.82) 0.057

CCL23/MIP3 0.88 (0.57 - 1.36) 0.86 (0.56 - 1.33) 0.717

CCL25/TECK 0.69 (0.44 - 1.08) 0.68 (0.43 - 1.08) 0.234

CCL28/MEC 0.74 (0.48 - 1.16) 0.74 (0.47 - 1.16) 0.372

CD244 1.20 (0.77 - 1.86) 1.11 (0.71 - 1.73) 0.789

CD40 1.36 (0.86 - 2.13) 1.39 (0.88 - 2.19) 0.333

CD5 2.21 (1.43 - 3.43) 2.21 (1.42 - 3.44) 0.006

CD6 1.84 (1.18 - 2.88) 1.79 (1.14 - 2.81) 0.048

CDCP1 1.12 (0.71 - 1.77) 1.13 (0.71 - 1.78) 0.789

CSF1 0.95 (0.62 - 1.46) 0.90 (0.58 - 1.40) 0.790

CST5 1.40 (0.91 - 2.18) 1.39 (0.89 - 2.17) 0.312

DNER 0.93 (0.60 - 1.43) 0.95 (0.61 - 1.48) 0.894

ENRAGE 1.91 (1.22 - 2.99) 1.84 (1.17 - 2.90) 0.037

FGF19 1.07 (0.70 - 1.66) 1.08 (0.70 - 1.67) 0.822

FGF21 1.16 (0.75 - 1.78) 1.14 (0.74 - 1.78) 0.765

FGF23 1.50 (0.97 - 2.33) 1.41 (0.90 - 2.20) 0.295

FLT3L 0.82 (0.52 - 1.28) 0.78 (0.49 - 1.22) 0.472

HGF 2.09 (1.33 - 3.29) 2.13 (1.34 - 3.37) 0.011

IL10RB 2.15 (1.37 - 3.36) 2.07 (1.31 - 3.27) 0.013

IL12B 1.48 (0.95 - 2.30) 1.35 (0.86 - 2.13) 0.372

IL18R1 2.24 (1.43 - 3.51) 2.14 (1.36 - 3.36) 0.009

IL18 1.56 (1.01 - 2.41) 1.55 (0.99 - 2.41) 0.175

TGFB1/LAB 1.52 (0.99 - 2.35) 1.49 (0.97 - 2.31) 0.219

LIFR 0.71 (0.46 - 1.10) 0.68 (0.43 - 1.06) 0.224

CCL7/MCP3 1.19 (0.77 - 1.84) 1.17 (0.75 - 1.82) 0.717

MMP1 0.97 (0.63 - 1.49) 0.98 (0.64 - 1.52) 0.971

MMP10 1.06 (0.68 - 1.63) 1.11 (0.71 - 1.74) 0.789

NT3 2.21 (1.39 - 3.52) 2.21 (1.38 - 3.53) 0.009

OPG 0.73 (0.47 - 1.14) 0.73 (0.47 - 1.14) 0.340

OSM 1.14 (0.71 - 1.84) 1.18 (0.73 - 1.90) 0.717

PDL1 1.24 (0.80 - 1.91) 1.24 (0.80 - 1.93) 0.546

SLAMF1 1.21 (0.78 - 1.85) 1.17 (0.76 - 1.81) 0.717

ST1A1 1.18 (0.75 - 1.85) 1.17 (0.74 - 1.85) 0.717

STAMPB 1.42 (0.91 - 2.19) 1.46 (0.94 - 2.26) 0.228

TNFB 1.71 (1.10 - 2.66) 1.59 (1.02 - 2.49) 0.141

TNFRSF9 1.98 (1.26 - 3.10) 1.95 (1.24 - 3.09) 0.024

TNFSF14 1.41 (0.91 - 2.20) 1.49 (0.95 - 2.34) 0.224

TRANCE 3.38 (2.15 - 5.32) 3.38 (2.14 - 5.35) < 0.001

TWEAK 0.77 (0.50 - 1.19) 0.71 (0.46 - 1.10) 0.277

UPA 0.80 (0.51 - 1.23) 0.80 (0.52 - 1.25) 0.546

VEGFA 1.99 (1.29 - 3.07) 1.99 (1.28 - 3.08) 0.015

IL29/IFNL1 0.96 (0.63 - 1.45) 0.98 (0.65 - 1.49) 0.965

IL33 0.90 (0.59 - 1.36) 0.90 (0.59 - 1.38) 0.789

IL4 0.80 (0.48 - 1.33) 0.76 (0.45 - 1.27) 0.495

TSLP 1.14 (0.71 - 1.85) 1.10 (0.67 - 1.80) 0.803

IL10RA 0.86 (0.44 - 1.68) 0.83 (0.41 - 1.66) 0.789

IL17C 1.24 (0.60 - 2.54) 1.21 (0.57 - 2.57) 0.789

SIRT2 0.54 (0.25 - 1.15) 0.62 (0.28 - 1.36) 0.423





Table S7. Associations between hyperglycemia and marker quantiles.


CCL21/6CKINE 1.06 (0.77 - 1.45) 1.05 (0.75 - 1.45) 0.970

CXCL13/BCA1 1.12 (0.83 - 1.53) 1.08 (0.78 - 1.48) 0.970

CCL19/MIP3B 1.06 (0.78 - 1.44) 1.09 (0.79 - 1.50) 0.970

CCL20/MIP3A 1.22 (0.89 - 1.66) 1.17 (0.85 - 1.62) 0.937

CRP 1.45 (1.06 - 1.98) 1.44 (1.04 - 1.98) 0.332

CCL27/CTACK 0.95 (0.70 - 1.29) 0.85 (0.62 - 1.17) 0.937

CXCL11/ITAC 1.18 (0.88 - 1.60) 1.00 (0.73 - 1.37) 0.998

CXCL6/GCP2 1.19 (0.88 - 1.63) 1.05 (0.76 - 1.46) 0.970

CXCL9/MIG 1.22 (0.90 - 1.67) 1.15 (0.84 - 1.59) 0.937

EGF 1.24 (0.90 - 1.70) 1.26 (0.90 - 1.75) 0.695

CXCL5/ENA78 1.08 (0.80 - 1.46) 0.97 (0.71 - 1.33) 0.970

CCL24/EOTAXIN2 0.97 (0.71 - 1.30) 1.05 (0.76 - 1.43) 0.970

CCL11/EOTAXIN 1.09 (0.80 - 1.49) 1.11 (0.80 - 1.53) 0.970

FGF2 1.07 (0.79 - 1.46) 1.06 (0.77 - 1.46) 0.970


GCSF 0.82 (0.60 - 1.12) 0.77 (0.56 - 1.06) 0.636

GMCSF 0.86 (0.62 - 1.20) 0.93 (0.66 - 1.31) 0.970

CXCL1/GRO 1.09 (0.80 - 1.49) 0.99 (0.72 - 1.37) 0.998

IL16 1.20 (0.88 - 1.65) 1.27 (0.91 - 1.76) 0.687

IL1RA 1.06 (0.78 - 1.43) 0.99 (0.72 - 1.36) 0.998

IL8 0.98 (0.71 - 1.35) 0.96 (0.68 - 1.34) 0.970

IL10 0.89 (0.63 - 1.26) 0.92 (0.64 - 1.32) 0.970

IL12p70 0.94 (0.67 - 1.32) 0.97 (0.68 - 1.37) 0.970

IL13 0.90 (0.64 - 1.25) 0.96 (0.68 - 1.35) 0.970

IL17A 0.84 (0.60 - 1.17) 0.87 (0.61 - 1.23) 0.937

IL1B 0.86 (0.61 - 1.22) 0.92 (0.64 - 1.31) 0.970

IL21 0.98 (0.69 - 1.39) 0.98 (0.68 - 1.41) 0.998

IL23 0.78 (0.56 - 1.09) 0.87 (0.61 - 1.23) 0.937

IL5 0.93 (0.67 - 1.30) 1.04 (0.74 - 1.46) 0.970

IL6 1.01 (0.71 - 1.43) 1.09 (0.76 - 1.57) 0.970

IL7 0.83 (0.59 - 1.16) 0.87 (0.61 - 1.23) 0.937

IP10 1.52 (1.11 - 2.07) 1.27 (0.92 - 1.75) 0.655

CCL2/MCP1 1.00 (0.74 - 1.37) 1.03 (0.74 - 1.43) 0.970

CCL8/MCP2 1.06 (0.79 - 1.44) 1.04 (0.76 - 1.42) 0.970

CCL13/MCP4 1.05 (0.77 - 1.43) 1.08 (0.78 - 1.49) 0.970

CCL22/MDC 1.05 (0.77 - 1.42) 1.05 (0.76 - 1.44) 0.970

CCL4/MIP1B 0.96 (0.70 - 1.32) 0.90 (0.65 - 1.25) 0.970

CCL15/MIP1D 1.05 (0.77 - 1.42) 1.09 (0.79 - 1.49) 0.970

CCL3/MIP1A 1.18 (0.83 - 1.67) 1.08 (0.75 - 1.55) 0.970

SAA 1.62 (1.20 - 2.21) 1.58 (1.15 - 2.17) 0.185

SAP 1.47 (1.07 - 2.03) 1.49 (1.07 - 2.09) 0.332

SCF 0.88 (0.64 - 1.19) 0.93 (0.68 - 1.29) 0.970

CXCL12/SDF1AB 0.86 (0.63 - 1.16) 0.81 (0.59 - 1.11) 0.730

SEGFR 1.30 (0.93 - 1.82) 1.24 (0.88 - 1.75) 0.804

SGP130 1.17 (0.84 - 1.65) 1.19 (0.84 - 1.69) 0.937

SIL4R 0.87 (0.62 - 1.21) 0.85 (0.60 - 1.20) 0.937

SIL6R 0.99 (0.71 - 1.38) 1.00 (0.70 - 1.42) 0.998

SILRII 1.65 (1.17 - 2.32) 1.61 (1.13 - 2.30) 0.232

STNFRI 0.93 (0.66 - 1.29) 0.96 (0.68 - 1.36) 0.970

STNFRII 0.90 (0.64 - 1.26) 0.90 (0.63 - 1.27) 0.970

SVEGFR2 1.13 (0.81 - 1.57) 1.06 (0.75 - 1.49) 0.970

SVEGFR3 1.07 (0.76 - 1.51) 1.01 (0.71 - 1.44) 0.998

CCL17/TARC 0.78 (0.58 - 1.06) 0.72 (0.52 - 0.98) 0.350

TGFA 0.99 (0.72 - 1.35) 1.01 (0.73 - 1.40) 0.998

TNFA 1.30 (0.95 - 1.79) 1.30 (0.93 - 1.81) 0.636

TPO 0.71 (0.52 - 0.96) 0.70 (0.51 - 0.96) 0.332

TRAIL 1.05 (0.77 - 1.42) 1.04 (0.76 - 1.42) 0.970

VEGF 0.95 (0.70 - 1.29) 0.94 (0.68 - 1.29) 0.970

ADA 1.94 (1.26 - 2.98) 2.22 (1.40 - 3.54) 0.042

AXIN1 1.48 (0.88 - 2.49) 1.61 (0.92 - 2.81) 0.597

BNGF 1.01 (0.66 - 1.55) 1.12 (0.71 - 1.77) 0.970

4E-BP1 1.78 (1.14 - 2.77) 1.68 (1.04 - 2.70) 0.332

CASP8 1.17 (0.76 - 1.80) 1.09 (0.69 - 1.73) 0.970

CCL23/MIP3 0.72 (0.47 - 1.10) 0.70 (0.44 - 1.10) 0.636

CCL25/TECK 1.41 (0.93 - 2.14) 1.52 (0.97 - 2.39) 0.486

CCL28/MEC 0.75 (0.49 - 1.15) 0.79 (0.50 - 1.25) 0.937

CD244 1.27 (0.83 - 1.95) 1.35 (0.85 - 2.13) 0.743

CD40 1.42 (0.92 - 2.19) 1.38 (0.87 - 2.21) 0.695

CD5 1.25 (0.82 - 1.91) 1.17 (0.74 - 1.86) 0.970

CD6 1.28 (0.84 - 1.96) 1.14 (0.72 - 1.80) 0.970

CDCP1 1.52 (0.98 - 2.36) 1.77 (1.09 - 2.85) 0.332

CSF1 1.03 (0.67 - 1.58) 1.11 (0.70 - 1.77) 0.970

CST5 1.17 (0.77 - 1.78) 1.07 (0.68 - 1.69) 0.970

DNER 1.09 (0.72 - 1.67) 1.03 (0.65 - 1.64) 0.998

ENRAGE 0.97 (0.64 - 1.46) 1.00 (0.64 - 1.56) 0.998

FGF19 0.68 (0.44 - 1.03) 0.71 (0.45 - 1.11) 0.655

FGF21 1.12 (0.74 - 1.71) 0.99 (0.63 - 1.57) 0.998

FGF23 0.89 (0.58 - 1.36) 0.95 (0.60 - 1.49) 0.970

FLT3L 1.52 (0.98 - 2.34) 1.57 (0.98 - 2.52) 0.478

HGF 1.39 (0.90 - 2.14) 1.63 (1.02 - 2.61) 0.350

IL10RB 1.22 (0.80 - 1.88) 1.24 (0.78 - 1.97) 0.937

IL12B 1.40 (0.90 - 2.17) 1.26 (0.78 - 2.02) 0.937

IL18R1 2.06 (1.34 - 3.17) 2.63 (1.65 - 4.19) 0.005

IL18 1.32 (0.86 - 2.02) 1.49 (0.94 - 2.35) 0.597

TGFB1/LAB 1.35 (0.89 - 2.06) 1.24 (0.79 - 1.97) 0.937

LIFR 1.90 (1.22 - 2.96) 1.68 (1.05 - 2.68) 0.332

CCL7/MCP3 1.47 (0.95 - 2.26) 1.70 (1.07 - 2.69) 0.332

MMP1 0.98 (0.64 - 1.51) 1.00 (0.64 - 1.58) 0.998

MMP10 0.93 (0.61 - 1.42) 1.07 (0.68 - 1.70) 0.970

NT3 0.71 (0.44 - 1.15) 0.70 (0.42 - 1.16) 0.695

OPG 1.14 (0.75 - 1.75) 1.24 (0.79 - 1.96) 0.937

OSM 0.78 (0.50 - 1.22) 0.84 (0.52 - 1.38) 0.970

PDL1 1.33 (0.87 - 2.03) 1.22 (0.77 - 1.93) 0.937

SLAMF1 0.90 (0.59 - 1.38) 0.81 (0.51 - 1.29) 0.937

ST1A1 1.15 (0.74 - 1.79) 1.00 (0.62 - 1.62) 0.998

STAMPB 1.20 (0.78 - 1.85) 1.26 (0.79 - 2.01) 0.937

TNFB 1.42 (0.92 - 2.20) 1.45 (0.91 - 2.33) 0.636

TNFRSF9 0.99 (0.64 - 1.53) 0.92 (0.58 - 1.47) 0.970

TNFSF14 1.02 (0.67 - 1.55) 1.06 (0.67 - 1.67) 0.970

TRANCE 1.47 (0.95 - 2.26) 1.42 (0.89 - 2.26) 0.655

TWEAK 1.01 (0.66 - 1.53) 0.90 (0.57 - 1.40) 0.970

UPA 0.74 (0.48 - 1.12) 0.83 (0.53 - 1.29) 0.937

VEGFA 1.04 (0.68 - 1.58) 1.08 (0.69 - 1.71) 0.970

IL29/IFNL1 0.95 (0.62 - 1.45) 1.00 (0.64 - 1.56) 0.998

IL33 0.95 (0.62 - 1.46) 1.06 (0.67 - 1.66) 0.970

IL4 1.08 (0.67 - 1.75) 1.23 (0.74 - 2.05) 0.937

TSLP 1.15 (0.70 - 1.89) 1.23 (0.73 - 2.07) 0.943

IL10RA 1.25 (0.66 - 2.37) 1.34 (0.66 - 2.72) 0.937

IL17C 0.68 (0.31 - 1.49) 0.76 (0.32 - 1.80) 0.970

SIRT2 1.21 (0.59 - 2.44) 1.24 (0.57 - 2.66) 0.970





Table S8. Associations between hypertension and marker quantiles.


CCL21/6CKINE 1.06 (0.80 - 1.39) 1.10 (0.83 - 1.45) 0.857

CXCL13/BCA1 1.00 (0.76 - 1.31) 1.01 (0.77 - 1.33) 0.954

CCL19/MIP3B 1.23 (0.94 - 1.62) 1.27 (0.97 - 1.68) 0.510

CCL20/MIP3A 1.12 (0.86 - 1.46) 1.18 (0.90 - 1.55) 0.616

CRP 1.02 (0.78 - 1.34) 1.07 (0.81 - 1.40) 0.936

CCL27/CTACK 0.68 (0.52 - 0.89) 0.70 (0.53 - 0.92) 0.192

CXCL11/ITAC 0.99 (0.76 - 1.30) 0.98 (0.74 - 1.29) 0.954

CXCL6/GCP2 0.87 (0.67 - 1.14) 0.89 (0.68 - 1.17) 0.799

CXCL9/MIG 0.98 (0.75 - 1.29) 0.98 (0.74 - 1.29) 0.954

EGF 0.99 (0.76 - 1.31) 0.97 (0.74 - 1.28) 0.954

CXCL5/ENA78 0.91 (0.70 - 1.19) 0.95 (0.73 - 1.25) 0.937

CCL24/EOTAXIN2 1.45 (1.10 - 1.89) 1.52 (1.15 - 2.00) 0.145

CCL11/EOTAXIN 1.15 (0.88 - 1.51) 1.24 (0.94 - 1.63) 0.521

FGF2 0.94 (0.72 - 1.24) 0.96 (0.73 - 1.26) 0.937


GCSF 0.97 (0.75 - 1.27) 0.99 (0.76 - 1.30) 0.954

GMCSF 0.74 (0.55 - 0.99) 0.71 (0.53 - 0.96) 0.326

CXCL1/GRO 0.78 (0.59 - 1.02) 0.80 (0.61 - 1.06) 0.521

IL16 0.99 (0.75 - 1.31) 0.99 (0.75 - 1.31) 0.954

IL1RA 0.83 (0.63 - 1.08) 0.84 (0.64 - 1.10) 0.581

IL8 0.76 (0.57 - 1.01) 0.79 (0.59 - 1.06) 0.521

IL10 0.78 (0.58 - 1.05) 0.77 (0.57 - 1.05) 0.510

IL12p70 0.80 (0.60 - 1.08) 0.81 (0.60 - 1.09) 0.521

IL13 0.80 (0.60 - 1.07) 0.80 (0.59 - 1.08) 0.521

IL17A 0.86 (0.64 - 1.14) 0.88 (0.66 - 1.18) 0.759

IL1B 0.73 (0.55 - 0.99) 0.71 (0.53 - 0.96) 0.327

IL21 0.67 (0.49 - 0.91) 0.67 (0.49 - 0.91) 0.192

IL23 0.85 (0.63 - 1.13) 0.85 (0.63 - 1.14) 0.629

IL5 0.64 (0.48 - 0.86) 0.65 (0.48 - 0.87) 0.145

IL6 0.82 (0.61 - 1.10) 0.84 (0.62 - 1.13) 0.624

IL7 0.89 (0.66 - 1.20) 0.90 (0.66 - 1.21) 0.855

IP10 0.75 (0.58 - 0.99) 0.75 (0.57 - 0.99) 0.375

CCL2/MCP1 1.25 (0.95 - 1.63) 1.26 (0.95 - 1.65) 0.521

CCL8/MCP2 1.14 (0.88 - 1.49) 1.16 (0.88 - 1.52) 0.648

CCL13/MCP4 1.28 (0.97 - 1.69) 1.32 (1.00 - 1.75) 0.442

CCL22/MDC 0.98 (0.75 - 1.28) 1.05 (0.80 - 1.38) 0.937

CCL4/MIP1B 0.78 (0.59 - 1.03) 0.80 (0.60 - 1.06) 0.521

CCL15/MIP1D 1.12 (0.86 - 1.46) 1.14 (0.87 - 1.49) 0.753

CCL3/MIP1A 0.88 (0.65 - 1.18) 0.89 (0.65 - 1.21) 0.842

SAA 1.18 (0.91 - 1.55) 1.22 (0.93 - 1.60) 0.521

SAP 1.14 (0.86 - 1.50) 1.09 (0.82 - 1.45) 0.881

SCF 1.21 (0.93 - 1.59) 1.27 (0.97 - 1.67) 0.510

CXCL12/SDF1AB 0.97 (0.74 - 1.27) 0.98 (0.75 - 1.29) 0.954

SEGFR 1.00 (0.74 - 1.34) 0.97 (0.72 - 1.31) 0.954

SGP130 1.10 (0.82 - 1.47) 1.10 (0.82 - 1.49) 0.857

SIL4R 0.96 (0.72 - 1.28) 0.94 (0.70 - 1.27) 0.937

SIL6R 0.93 (0.70 - 1.24) 0.91 (0.68 - 1.22) 0.857

SILRII 1.13 (0.84 - 1.51) 1.09 (0.81 - 1.47) 0.890

STNFRI 0.82 (0.61 - 1.10) 0.88 (0.65 - 1.18) 0.756

STNFRII 0.76 (0.57 - 1.03) 0.80 (0.59 - 1.08) 0.521

SVEGFR2 0.89 (0.66 - 1.20) 0.87 (0.65 - 1.18) 0.756

SVEGFR3 1.17 (0.87 - 1.56) 1.20 (0.89 - 1.61) 0.616

CCL17/TARC 0.73 (0.56 - 0.96) 0.79 (0.60 - 1.04) 0.510

TGFA 0.70 (0.53 - 0.92) 0.70 (0.53 - 0.93) 0.203

TNFA 1.06 (0.80 - 1.39) 1.09 (0.83 - 1.45) 0.857

TPO 1.08 (0.83 - 1.42) 1.09 (0.83 - 1.43) 0.857

TRAIL 1.18 (0.90 - 1.54) 1.22 (0.93 - 1.60) 0.521

VEGF 1.11 (0.85 - 1.46) 1.17 (0.89 - 1.54) 0.629

ADA 1.00 (0.69 - 1.45) 0.98 (0.67 - 1.43) 0.954

AXIN1 1.15 (0.73 - 1.81) 1.07 (0.68 - 1.70) 0.937

BNGF 1.31 (0.90 - 1.91) 1.27 (0.87 - 1.86) 0.592

4E-BP1 0.96 (0.65 - 1.41) 0.96 (0.65 - 1.41) 0.954

CASP8 1.21 (0.83 - 1.76) 1.15 (0.79 - 1.69) 0.854

CCL23/MIP3 0.85 (0.58 - 1.24) 0.84 (0.58 - 1.22) 0.756

CCL25/TECK 0.88 (0.61 - 1.28) 0.90 (0.62 - 1.31) 0.890

CCL28/MEC 0.81 (0.55 - 1.18) 0.77 (0.53 - 1.14) 0.573

CD244 0.89 (0.61 - 1.28) 0.88 (0.61 - 1.28) 0.857

CD40 1.05 (0.73 - 1.52) 1.04 (0.72 - 1.51) 0.954

CD5 1.07 (0.74 - 1.56) 1.08 (0.74 - 1.58) 0.937

CD6 1.07 (0.73 - 1.55) 1.02 (0.70 - 1.49) 0.954

CDCP1 1.13 (0.77 - 1.66) 1.11 (0.75 - 1.64) 0.912

CSF1 1.07 (0.74 - 1.55) 1.04 (0.71 - 1.51) 0.954

CST5 1.10 (0.76 - 1.59) 1.07 (0.74 - 1.56) 0.937

DNER 0.83 (0.57 - 1.21) 0.82 (0.56 - 1.19) 0.648

ENRAGE 0.80 (0.55 - 1.16) 0.77 (0.53 - 1.13) 0.564

FGF19 1.00 (0.68 - 1.45) 0.95 (0.65 - 1.40) 0.954

FGF21 1.37 (0.94 - 1.99) 1.29 (0.88 - 1.89) 0.573

FGF23 1.07 (0.74 - 1.54) 1.06 (0.73 - 1.53) 0.937

FLT3L 1.10 (0.75 - 1.60) 1.07 (0.74 - 1.57) 0.937

HGF 0.95 (0.65 - 1.39) 0.94 (0.64 - 1.39) 0.937

IL10RB 1.32 (0.91 - 1.91) 1.33 (0.91 - 1.93) 0.521

IL12B 0.82 (0.56 - 1.19) 0.82 (0.56 - 1.20) 0.673

IL18R1 1.54 (1.06 - 2.24) 1.50 (1.03 - 2.19) 0.364

IL18 1.14 (0.78 - 1.65) 1.11 (0.76 - 1.62) 0.893

TGFB1/LAB 1.07 (0.74 - 1.55) 1.02 (0.70 - 1.48) 0.954

LIFR 1.30 (0.90 - 1.89) 1.25 (0.86 - 1.82) 0.617

CCL7/MCP3 0.74 (0.51 - 1.08) 0.72 (0.49 - 1.06) 0.510

MMP1 0.84 (0.58 - 1.22) 0.80 (0.55 - 1.18) 0.629

MMP10 0.93 (0.64 - 1.35) 0.94 (0.64 - 1.37) 0.937

NT3 1.03 (0.68 - 1.55) 1.02 (0.67 - 1.55) 0.954

OPG 0.95 (0.65 - 1.38) 0.91 (0.62 - 1.33) 0.922

OSM 0.45 (0.30 - 0.68) 0.45 (0.30 - 0.68) 0.017

PDL1 1.08 (0.75 - 1.57) 1.08 (0.74 - 1.56) 0.937

SLAMF1 0.86 (0.60 - 1.25) 0.84 (0.58 - 1.22) 0.753

ST1A1 1.07 (0.73 - 1.57) 1.03 (0.70 - 1.52) 0.954

STAMPB 0.96 (0.66 - 1.40) 0.95 (0.65 - 1.38) 0.937

TNFB 0.72 (0.49 - 1.06) 0.72 (0.49 - 1.06) 0.510

TNFRSF9 0.77 (0.53 - 1.13) 0.79 (0.54 - 1.16) 0.616

TNFSF14 0.57 (0.39 - 0.84) 0.58 (0.39 - 0.85) 0.162

TRANCE 1.48 (1.02 - 2.15) 1.51 (1.03 - 2.20) 0.362

TWEAK 0.97 (0.67 - 1.42) 1.01 (0.69 - 1.48) 0.954

UPA 0.84 (0.58 - 1.22) 0.88 (0.60 - 1.29) 0.857

VEGFA 0.97 (0.67 - 1.40) 0.91 (0.63 - 1.33) 0.922

IL29/IFNL1 1.30 (0.90 - 1.89) 1.32 (0.90 - 1.92) 0.521

IL33 1.06 (0.73 - 1.55) 1.02 (0.69 - 1.49) 0.954

IL4 0.91 (0.60 - 1.39) 0.92 (0.60 - 1.42) 0.937

TSLP 0.91 (0.59 - 1.41) 0.91 (0.58 - 1.43) 0.937

IL10RA 0.61 (0.35 - 1.08) 0.64 (0.36 - 1.15) 0.521

IL17C 1.92 (0.95 - 3.86) 1.97 (0.96 - 4.05) 0.483

SIRT2 1.37 (0.75 - 2.50) 1.32 (0.71 - 2.46) 0.756





Table S9. Participants per marker quantile with given characteristic.Marker

- + - + - + - + - + - + - +

6CKINE

Q1 265 (42.6) 62 (40.8) 255 (43.6) 61 (38.1) 243 (42.8) 78 (42.9) 259 (44.6) 68 (35.2) 237 (43.6) 86 (39.4) 134 (43.6) 186 (42.0) 225 (42.1) 69 (42.9)

Q2 122 (19.6) 27 (17.8) 114 (19.5) 31 (19.4) 110 (19.4) 34 (18.7) 111 (19.1) 38 (19.7) 106 (19.5) 41 (18.8) 59 (19.2) 87 (19.6) 107 (20.0) 25 (15.5)

Q3 112 (18.0) 37 (24.3) 115 (19.7) 27 (16.9) 102 (18.0) 40 (22.0) 104 (17.9) 45 (23.3) 98 (18.0) 47 (21.6) 49 (16.0) 93 (21.0) 97 (18.2) 35 (21.7)

Q4 123 (19.8) 26 (17.1) 101 (17.3) 41 (25.6) 113 (19.9) 30 (16.5) 107 (18.4) 42 (21.8) 103 (18.9) 44 (20.2) 65 (21.2) 77 (17.4) 105 (19.7) 32 (19.9)

BCA1

Q1 169 (27.2) 24 (15.8) 151 (25.8) 35 (21.9) 158 (27.8) 31 (17.0) 158 (27.2) 35 (18.1) 145 (26.7) 43 (19.7) 75 (24.4) 113 (25.5) 129 (24.2) 37 (23.0)

Q2 145 (23.3) 49 (32.2) 153 (26.2) 33 (20.6) 136 (23.9) 53 (29.1) 142 (24.4) 52 (26.9) 138 (25.4) 53 (24.3) 75 (24.4) 114 (25.7) 134 (25.1) 42 (26.1)

Q3 161 (25.9) 33 (21.7) 143 (24.4) 43 (26.9) 137 (24.1) 50 (27.5) 151 (26.0) 43 (22.3) 133 (24.4) 57 (26.1) 77 (25.1) 111 (25.1) 140 (26.2) 41 (25.5)

Q4 147 (23.6) 46 (30.3) 138 (23.6) 49 (30.6) 137 (24.1) 48 (26.4) 130 (22.4) 63 (32.6) 128 (23.5) 65 (29.8) 80 (26.1) 105 (23.7) 131 (24.5) 41 (25.5)

CCL19/MIP3B

Q1 176 (28.5) 16 (10.7) 168 (28.9) 19 (12.0) 163 (28.8) 27 (15.2) 163 (28.2) 29 (15.2) 152 (28.1) 36 (16.7) 94 (30.7) 97 (22.1) 128 (24.2) 38 (23.9)

Q2 155 (25.1) 37 (24.7) 139 (23.9) 46 (29.1) 144 (25.4) 41 (23.0) 152 (26.3) 40 (20.9) 136 (25.1) 53 (24.7) 69 (22.5) 117 (26.7) 134 (25.3) 45 (28.3)

Q3 150 (24.3) 42 (28.0) 137 (23.6) 50 (31.6) 135 (23.9) 47 (26.4) 133 (23.1) 59 (30.9) 128 (23.7) 61 (28.4) 76 (24.8) 105 (24.0) 139 (26.2) 34 (21.4)

Q4 137 (22.2) 55 (36.7) 137 (23.6) 43 (27.2) 124 (21.9) 63 (35.4) 129 (22.4) 63 (33.0) 125 (23.1) 65 (30.2) 67 (21.9) 119 (27.2) 129 (24.3) 42 (26.4)

CCL20/MIP3A

Q1 152 (24.6) 40 (26.7) 150 (25.8) 35 (22.2) 148 (26.1) 40 (22.5) 150 (26.0) 42 (22.0) 127 (23.5) 63 (29.3) 85 (27.8) 103 (23.5) 133 (25.1) 35 (22.0)

Q2 165 (26.7) 27 (18.0) 143 (24.6) 38 (24.1) 141 (24.9) 44 (24.7) 155 (26.9) 37 (19.4) 143 (26.4) 44 (20.5) 74 (24.2) 110 (25.1) 142 (26.8) 37 (23.3)

Q3 160 (25.9) 32 (21.3) 140 (24.1) 48 (30.4) 144 (25.4) 41 (23.0) 142 (24.6) 50 (26.2) 141 (26.1) 47 (21.9) 83 (27.1) 103 (23.5) 127 (24.0) 38 (23.9)

Q4 141 (22.8) 51 (34.0) 148 (25.5) 37 (23.4) 133 (23.5) 53 (29.8) 130 (22.5) 62 (32.5) 130 (24.0) 61 (28.4) 64 (20.9) 122 (27.9) 128 (24.2) 49 (30.8)

CRP

Q1 176 (28.3) 17 (11.3) 152 (26.0) 35 (22.0) 157 (27.7) 30 (16.5) 163 (28.2) 30 (15.5) 159 (29.3) 27 (12.4) 89 (29.0) 98 (22.2) 141 (26.5) 30 (18.8)

Q2 159 (25.6) 34 (22.5) 155 (26.5) 33 (20.8) 141 (24.9) 48 (26.4) 150 (25.9) 43 (22.3) 143 (26.3) 47 (21.7) 75 (24.4) 112 (25.4) 140 (26.3) 35 (21.9)

Q3 148 (23.8) 45 (29.8) 138 (23.6) 47 (29.6) 141 (24.9) 46 (25.3) 145 (25.0) 48 (24.9) 123 (22.7) 70 (32.3) 66 (21.5) 122 (27.7) 133 (25.0) 46 (28.7)

Q4 138 (22.2) 55 (36.4) 140 (23.9) 44 (27.7) 127 (22.4) 58 (31.9) 121 (20.9) 72 (37.3) 118 (21.7) 73 (33.6) 77 (25.1) 109 (24.7) 119 (22.3) 49 (30.6)

CTACK

Q1 152 (24.4) 41 (27.0) 152 (26.0) 32 (20.0) 144 (25.4) 39 (21.4) 136 (23.4) 57 (29.5) 129 (23.7) 61 (28.0) 66 (21.5) 118 (26.6) 133 (24.9) 35 (21.7)

Q2 152 (24.4) 42 (27.6) 148 (25.3) 39 (24.4) 143 (25.2) 47 (25.8) 148 (25.5) 46 (23.8) 145 (26.7) 45 (20.6) 72 (23.5) 117 (26.4) 122 (22.8) 43 (26.7)

Q3 154 (24.8) 40 (26.3) 155 (26.5) 33 (20.6) 138 (24.3) 49 (26.9) 151 (26.0) 43 (22.3) 123 (22.6) 70 (32.1) 82 (26.7) 105 (23.7) 139 (26.0) 40 (24.8)

Q4 164 (26.4) 29 (19.1) 130 (22.2) 56 (35.0) 143 (25.2) 47 (25.8) 146 (25.1) 47 (24.4) 147 (27.0) 42 (19.3) 87 (28.3) 103 (23.3) 140 (26.2) 43 (26.7)

CXCL11/ITAC

Q1 164 (26.5) 28 (18.7) 156 (26.9) 31 (19.6) 145 (25.6) 38 (21.3) 157 (27.2) 35 (18.3) 145 (26.8) 44 (20.5) 74 (24.2) 109 (24.9) 137 (25.8) 32 (20.1)

Q2 155 (25.1) 37 (24.7) 139 (23.9) 48 (30.4) 136 (24.0) 50 (28.1) 142 (24.6) 50 (26.2) 139 (25.7) 51 (23.7) 85 (27.8) 101 (23.1) 133 (25.1) 36 (22.6)

Q3 149 (24.1) 43 (28.7) 144 (24.8) 39 (24.7) 137 (24.2) 50 (28.1) 139 (24.1) 53 (27.7) 128 (23.7) 59 (27.4) 68 (22.2) 119 (27.2) 123 (23.2) 49 (30.8)

Q4 150 (24.3) 42 (28.0) 142 (24.4) 40 (25.3) 148 (26.1) 40 (22.5) 139 (24.1) 53 (27.7) 129 (23.8) 61 (28.4) 79 (25.8) 109 (24.9) 137 (25.8) 42 (26.4)

CXCL6/GCP2

Q1 156 (25.2) 36 (24.0) 149 (25.6) 37 (23.4) 146 (25.8) 42 (23.6) 154 (26.7) 38 (19.9) 141 (26.1) 51 (23.7) 76 (24.8) 112 (25.6) 131 (24.7) 42 (26.4)

Q2 158 (25.6) 34 (22.7) 144 (24.8) 38 (24.1) 141 (24.9) 43 (24.2) 158 (27.4) 34 (17.8) 138 (25.5) 50 (23.3) 67 (21.9) 118 (26.9) 137 (25.8) 39 (24.5)

Q3 160 (25.9) 32 (21.3) 144 (24.8) 41 (25.9) 137 (24.2) 47 (26.4) 137 (23.7) 55 (28.8) 142 (26.2) 46 (21.4) 87 (28.4) 98 (22.4) 134 (25.3) 37 (23.3)

Q4 144 (23.3) 48 (32.0) 144 (24.8) 42 (26.6) 142 (25.1) 46 (25.8) 128 (22.2) 64 (33.5) 120 (22.2) 68 (31.6) 76 (24.8) 110 (25.1) 128 (24.2) 41 (25.8)

CXCL9/MIG

Q1 167 (27.0) 25 (16.7) 156 (26.9) 32 (20.3) 145 (25.6) 38 (21.3) 157 (27.2) 35 (18.3) 143 (26.4) 46 (21.4) 94 (30.7) 90 (20.5) 140 (26.4) 33 (20.8)

Q2 151 (24.4) 41 (27.3) 136 (23.4) 47 (29.7) 140 (24.7) 46 (25.8) 151 (26.2) 41 (21.5) 136 (25.1) 54 (25.1) 69 (22.5) 116 (26.5) 137 (25.8) 37 (23.3)

Q3 153 (24.8) 39 (26.0) 145 (25.0) 41 (25.9) 137 (24.2) 49 (27.5) 142 (24.6) 50 (26.2) 127 (23.5) 62 (28.8) 71 (23.2) 115 (26.3) 121 (22.8) 45 (28.3)

HyperglycemiaMtS Low PA High TG Low HDL Obesity Hypertension

Q4 147 (23.8) 45 (30.0) 144 (24.8) 38 (24.1) 144 (25.4) 45 (25.3) 127 (22.0) 65 (34.0) 135 (25.0) 53 (24.7) 72 (23.5) 117 (26.7) 132 (24.9) 44 (27.7)

EGF

Q1 149 (24.0) 44 (28.9) 150 (25.6) 37 (23.1) 148 (26.1) 37 (20.3) 145 (25.0) 48 (24.9) 125 (23.0) 66 (30.3) 76 (24.8) 109 (24.6) 132 (24.7) 41 (25.5)

Q2 167 (26.8) 27 (17.8) 134 (22.9) 49 (30.6) 159 (28.0) 31 (17.0) 158 (27.2) 36 (18.7) 136 (25.0) 56 (25.7) 85 (27.7) 105 (23.7) 146 (27.3) 32 (19.9)

Q3 150 (24.1) 44 (28.9) 151 (25.8) 40 (25.0) 131 (23.1) 57 (31.3) 141 (24.3) 53 (27.5) 140 (25.7) 51 (23.4) 74 (24.1) 115 (26.0) 130 (24.3) 41 (25.5)

Q4 156 (25.1) 37 (24.3) 150 (25.6) 34 (21.2) 130 (22.9) 57 (31.3) 137 (23.6) 56 (29.0) 143 (26.3) 45 (20.6) 72 (23.5) 114 (25.7) 126 (23.6) 47 (29.2)

ENA78

Q1 159 (25.6) 34 (22.4) 133 (22.7) 48 (30.0) 150 (26.4) 41 (22.5) 156 (26.9) 37 (19.2) 139 (25.6) 51 (23.4) 68 (22.1) 124 (28.0) 137 (25.7) 40 (24.8)

Q2 155 (24.9) 39 (25.7) 140 (23.9) 48 (30.0) 136 (23.9) 46 (25.3) 149 (25.6) 45 (23.3) 137 (25.2) 57 (26.1) 80 (26.1) 102 (23.0) 123 (23.0) 45 (28.0)

Q3 153 (24.6) 41 (27.0) 159 (27.2) 29 (18.1) 143 (25.2) 46 (25.3) 141 (24.3) 53 (27.5) 131 (24.1) 60 (27.5) 85 (27.7) 104 (23.5) 134 (25.1) 36 (22.4)

Q4 155 (24.9) 38 (25.0) 153 (26.2) 35 (21.9) 139 (24.5) 49 (26.9) 135 (23.2) 58 (30.1) 137 (25.2) 50 (22.9) 74 (24.1) 113 (25.5) 140 (26.2) 40 (24.8)

EOTAXIN2

Q1 159 (25.6) 34 (22.4) 151 (25.8) 38 (23.8) 140 (24.6) 49 (26.9) 142 (24.4) 51 (26.4) 137 (25.2) 55 (25.2) 91 (29.6) 100 (22.6) 145 (27.2) 35 (21.7)

Q2 157 (25.2) 37 (24.3) 142 (24.3) 45 (28.1) 144 (25.4) 41 (22.5) 146 (25.1) 48 (24.9) 143 (26.3) 50 (22.9) 80 (26.1) 105 (23.7) 131 (24.5) 44 (27.3)

Q3 156 (25.1) 38 (25.0) 142 (24.3) 44 (27.5) 143 (25.2) 46 (25.3) 140 (24.1) 54 (28.0) 134 (24.6) 55 (25.2) 86 (28.0) 102 (23.0) 126 (23.6) 44 (27.3)

Q4 150 (24.1) 43 (28.3) 150 (25.6) 33 (20.6) 141 (24.8) 46 (25.3) 153 (26.3) 40 (20.7) 130 (23.9) 58 (26.6) 50 (16.3) 136 (30.7) 132 (24.7) 38 (23.6)

EOTAXIN

Q1 150 (24.1) 43 (28.3) 146 (25.0) 40 (25.0) 146 (25.7) 42 (23.1) 138 (23.8) 55 (28.5) 129 (23.7) 63 (28.9) 98 (31.9) 90 (20.3) 146 (27.3) 32 (19.9)

Q2 154 (24.8) 40 (26.3) 143 (24.4) 44 (27.5) 135 (23.8) 52 (28.6) 149 (25.6) 45 (23.3) 134 (24.6) 58 (26.6) 72 (23.5) 116 (26.2) 125 (23.4) 46 (28.6)

Q3 160 (25.7) 34 (22.4) 150 (25.6) 39 (24.4) 142 (25.0) 43 (23.6) 142 (24.4) 52 (26.9) 146 (26.8) 45 (20.6) 72 (23.5) 113 (25.5) 131 (24.5) 37 (23.0)

Q4 158 (25.4) 35 (23.0) 146 (25.0) 37 (23.1) 145 (25.5) 45 (24.7) 152 (26.2) 41 (21.2) 135 (24.8) 52 (23.9) 65 (21.2) 124 (28.0) 132 (24.7) 46 (28.6)

FGF2

Q1 233 (37.5) 55 (36.2) 225 (38.5) 51 (31.9) 213 (37.5) 69 (37.9) 220 (37.9) 68 (35.2) 205 (37.7) 78 (35.8) 115 (37.5) 167 (37.7) 198 (37.1) 58 (36.0)

Q2 125 (20.1) 37 (24.3) 127 (21.7) 31 (19.4) 114 (20.1) 44 (24.2) 118 (20.3) 44 (22.8) 105 (19.3) 54 (24.8) 58 (18.9) 100 (22.6) 108 (20.2) 36 (22.4)

Q3 127 (20.4) 35 (23.0) 124 (21.2) 33 (20.6) 120 (21.1) 36 (19.8) 122 (21.0) 40 (20.7) 111 (20.4) 50 (22.9) 69 (22.5) 87 (19.6) 111 (20.8) 38 (23.6)

Q4 137 (22.0) 25 (16.4) 109 (18.6) 45 (28.1) 121 (21.3) 33 (18.1) 121 (20.8) 41 (21.2) 123 (22.6) 36 (16.5) 65 (21.2) 89 (20.1) 117 (21.9) 29 (18.0)

GRO

Q1 153 (24.6) 40 (26.3) 140 (23.9) 44 (27.5) 142 (25.0) 46 (25.3) 150 (25.8) 43 (22.3) 134 (24.6) 58 (26.6) 73 (23.8) 114 (25.7) 138 (25.8) 41 (25.5)

Q2 150 (24.1) 44 (28.9) 142 (24.3) 42 (26.2) 141 (24.8) 47 (25.8) 155 (26.7) 39 (20.2) 126 (23.2) 66 (30.3) 73 (23.8) 115 (26.0) 132 (24.7) 42 (26.1)

Q3 157 (25.2) 37 (24.3) 152 (26.0) 37 (23.1) 135 (23.8) 52 (28.6) 138 (23.8) 56 (29.0) 141 (25.9) 50 (22.9) 79 (25.7) 109 (24.6) 133 (24.9) 36 (22.4)

Q4 162 (26.0) 31 (20.4) 151 (25.8) 37 (23.1) 150 (26.4) 37 (20.3) 138 (23.8) 55 (28.5) 143 (26.3) 44 (20.2) 82 (26.7) 105 (23.7) 131 (24.5) 42 (26.1)

GCSF

Q1 160 (25.7) 33 (21.7) 141 (24.1) 44 (27.5) 151 (26.6) 39 (21.4) 154 (26.5) 39 (20.2) 131 (24.1) 59 (27.1) 73 (23.8) 115 (26.0) 130 (24.3) 41 (25.5)

Q2 144 (23.2) 50 (32.9) 155 (26.5) 31 (19.4) 129 (22.7) 56 (30.8) 128 (22.0) 66 (34.2) 131 (24.1) 58 (26.6) 68 (22.1) 119 (26.9) 126 (23.6) 46 (28.6)

Q3 157 (25.2) 37 (24.3) 145 (24.8) 39 (24.4) 148 (26.1) 44 (24.2) 155 (26.7) 39 (20.2) 137 (25.2) 55 (25.2) 88 (28.7) 104 (23.5) 142 (26.6) 36 (22.4)

Q4 161 (25.9) 32 (21.1) 144 (24.6) 46 (28.7) 140 (24.6) 43 (23.6) 144 (24.8) 49 (25.4) 145 (26.7) 46 (21.1) 78 (25.4) 105 (23.7) 136 (25.5) 38 (23.6)

IL16

Q1 155 (24.9) 38 (25.0) 150 (25.6) 32 (20.0) 149 (26.2) 40 (22.0) 142 (24.4) 51 (26.4) 123 (22.6) 62 (28.4) 82 (26.7) 108 (24.4) 135 (25.3) 38 (23.6)

Q2 163 (26.2) 31 (20.4) 151 (25.8) 36 (22.5) 156 (27.5) 31 (17.0) 155 (26.7) 39 (20.2) 142 (26.1) 50 (22.9) 70 (22.8) 117 (26.4) 134 (25.1) 35 (21.7)

Q3 151 (24.3) 43 (28.3) 144 (24.6) 45 (28.1) 133 (23.4) 54 (29.7) 136 (23.4) 58 (30.1) 137 (25.2) 56 (25.7) 78 (25.4) 108 (24.4) 131 (24.5) 44 (27.3)

Q4 153 (24.6) 40 (26.3) 140 (23.9) 47 (29.4) 130 (22.9) 57 (31.3) 148 (25.5) 45 (23.3) 142 (26.1) 50 (22.9) 77 (25.1) 110 (24.8) 134 (25.1) 44 (27.3)

IL1RA

Q1 191 (30.7) 56 (36.8) 191 (32.6) 46 (28.7) 171 (30.1) 69 (37.9) 178 (30.6) 69 (35.8) 173 (31.8) 68 (31.2) 92 (30.0) 147 (33.2) 174 (32.6) 44 (27.3)

Q2 143 (23.0) 31 (20.4) 128 (21.9) 41 (25.6) 133 (23.4) 38 (20.9) 134 (23.1) 40 (20.7) 122 (22.4) 49 (22.5) 63 (20.5) 109 (24.6) 117 (21.9) 42 (26.1)

Q3 142 (22.8) 35 (23.0) 142 (24.3) 28 (17.5) 131 (23.1) 41 (22.5) 138 (23.8) 39 (20.2) 124 (22.8) 52 (23.9) 74 (24.1) 98 (22.1) 116 (21.7) 45 (28.0)

Q4 146 (23.5) 30 (19.7) 124 (21.2) 45 (28.1) 133 (23.4) 34 (18.7) 131 (22.5) 45 (23.3) 125 (23.0) 49 (22.5) 78 (25.4) 89 (20.1) 127 (23.8) 30 (18.6)

IL29IFNL1

Q1 494 (79.9) 110 (73.3) 456 (78.5) 127 (80.4) 447 (79.0) 139 (78.1) 457 (79.2) 147 (77.0) 427 (78.9) 167 (77.7) 249 (81.4) 337 (76.9) 413 (77.9) 123 (77.4)

Q2 124 (20.1) 40 (26.7) 125 (21.5) 31 (19.6) 119 (21.0) 39 (21.9) 120 (20.8) 44 (23.0) 114 (21.1) 48 (22.3) 57 (18.6) 101 (23.1) 117 (22.1) 36 (22.6)

IL33

Q1 494 (79.4) 121 (79.6) 472 (80.7) 121 (75.6) 452 (79.6) 144 (79.1) 468 (80.6) 147 (76.2) 431 (79.2) 174 (79.8) 241 (78.5) 354 (79.9) 417 (78.1) 129 (80.1)

Q2 128 (20.6) 31 (20.4) 113 (19.3) 39 (24.4) 116 (20.4) 38 (20.9) 113 (19.4) 46 (23.8) 113 (20.8) 44 (20.2) 66 (21.5) 89 (20.1) 117 (21.9) 32 (19.9)

IL8

Q1 151 (24.3) 42 (27.6) 133 (22.7) 53 (33.1) 132 (23.2) 54 (29.7) 140 (24.1) 53 (27.5) 135 (24.8) 56 (25.7) 79 (25.7) 106 (23.9) 139 (26.0) 44 (27.3)

Q2 156 (25.1) 38 (25.0) 142 (24.3) 44 (27.5) 144 (25.4) 44 (24.2) 152 (26.2) 42 (21.8) 140 (25.7) 50 (22.9) 86 (28.0) 102 (23.0) 136 (25.5) 37 (23.0)

Q3 160 (25.7) 34 (22.4) 156 (26.7) 29 (18.1) 144 (25.4) 46 (25.3) 152 (26.2) 42 (21.8) 139 (25.6) 53 (24.3) 67 (21.8) 123 (27.8) 132 (24.7) 38 (23.6)

Q4 155 (24.9) 38 (25.0) 154 (26.3) 34 (21.2) 148 (26.1) 38 (20.9) 137 (23.6) 56 (29.0) 130 (23.9) 59 (27.1) 75 (24.4) 112 (25.3) 127 (23.8) 42 (26.1)

IP10

Q1 155 (24.9) 38 (25.0) 147 (25.1) 38 (23.8) 142 (25.0) 43 (23.6) 148 (25.5) 45 (23.3) 147 (27.0) 45 (20.6) 70 (22.8) 116 (26.2) 133 (24.9) 36 (22.4)

Q2 165 (26.5) 29 (19.1) 150 (25.6) 39 (24.4) 141 (24.8) 44 (24.2) 153 (26.3) 41 (21.2) 138 (25.4) 53 (24.3) 78 (25.4) 107 (24.2) 141 (26.4) 29 (18.0)

Q3 156 (25.1) 38 (25.0) 149 (25.5) 39 (24.4) 146 (25.7) 44 (24.2) 150 (25.8) 44 (22.8) 136 (25.0) 54 (24.8) 75 (24.4) 115 (26.0) 132 (24.7) 47 (29.2)

Q4 146 (23.5) 47 (30.9) 139 (23.8) 44 (27.5) 139 (24.5) 51 (28.0) 130 (22.4) 63 (32.6) 123 (22.6) 66 (30.3) 84 (27.4) 105 (23.7) 128 (24.0) 49 (30.4)

MCP1

Q1 163 (26.2) 30 (19.7) 161 (27.5) 29 (18.1) 155 (27.3) 34 (18.7) 149 (25.6) 44 (22.8) 142 (26.1) 51 (23.4) 85 (27.7) 105 (23.7) 134 (25.1) 35 (21.7)

Q2 163 (26.2) 31 (20.4) 152 (26.0) 34 (21.2) 158 (27.8) 34 (18.7) 160 (27.5) 34 (17.6) 139 (25.6) 51 (23.4) 88 (28.7) 104 (23.5) 129 (24.2) 43 (26.7)

Q3 149 (24.0) 45 (29.6) 134 (22.9) 50 (31.2) 123 (21.7) 59 (32.4) 139 (23.9) 55 (28.5) 139 (25.6) 52 (23.9) 68 (22.1) 115 (26.0) 138 (25.8) 36 (22.4)

Q4 147 (23.6) 46 (30.3) 138 (23.6) 47 (29.4) 132 (23.2) 55 (30.2) 133 (22.9) 60 (31.1) 124 (22.8) 64 (29.4) 66 (21.5) 119 (26.9) 133 (24.9) 47 (29.2)

MCP2

Q1 161 (25.9) 32 (21.1) 148 (25.3) 36 (22.5) 139 (24.5) 50 (27.5) 150 (25.8) 43 (22.3) 138 (25.4) 52 (23.9) 81 (26.4) 107 (24.2) 133 (24.9) 34 (21.1)

Q2 157 (25.2) 37 (24.3) 148 (25.3) 42 (26.2) 147 (25.9) 42 (23.1) 147 (25.3) 47 (24.4) 138 (25.4) 52 (23.9) 86 (28.0) 103 (23.3) 136 (25.5) 40 (24.8)

Q3 142 (22.8) 52 (34.2) 141 (24.1) 43 (26.9) 132 (23.2) 55 (30.2) 136 (23.4) 58 (30.1) 133 (24.4) 60 (27.5) 71 (23.1) 116 (26.2) 129 (24.2) 47 (29.2)

Q4 162 (26.0) 31 (20.4) 148 (25.3) 39 (24.4) 150 (26.4) 35 (19.2) 148 (25.5) 45 (23.3) 135 (24.8) 54 (24.8) 69 (22.5) 117 (26.4) 136 (25.5) 40 (24.8)

MCP4

Q1 290 (46.6) 59 (38.8) 266 (45.5) 68 (42.5) 260 (45.8) 77 (42.3) 268 (46.1) 81 (42.0) 241 (44.3) 100 (45.9) 149 (48.5) 188 (42.4) 240 (44.9) 68 (42.2)

Q2 112 (18.0) 28 (18.4) 112 (19.1) 24 (15.0) 102 (18.0) 31 (17.0) 106 (18.2) 34 (17.6) 98 (18.0) 42 (19.3) 50 (16.3) 84 (19.0) 89 (16.7) 35 (21.7)

Q3 105 (16.9) 37 (24.3) 111 (19.0) 25 (15.6) 100 (17.6) 41 (22.5) 101 (17.4) 41 (21.2) 100 (18.4) 41 (18.8) 54 (17.6) 86 (19.4) 99 (18.5) 31 (19.3)

Q4 115 (18.5) 28 (18.4) 96 (16.4) 43 (26.9) 106 (18.7) 33 (18.1) 106 (18.2) 37 (19.2) 105 (19.3) 35 (16.1) 54 (17.6) 85 (19.2) 106 (19.9) 27 (16.8)

MDC

Q1 153 (24.6) 40 (26.3) 147 (25.1) 40 (25.0) 148 (26.1) 41 (22.5) 146 (25.1) 47 (24.4) 129 (23.7) 60 (27.5) 74 (24.1) 116 (26.2) 133 (24.9) 42 (26.1)

Q2 158 (25.4) 36 (23.7) 145 (24.8) 40 (25.0) 136 (23.9) 51 (28.0) 149 (25.6) 45 (23.3) 146 (26.8) 45 (20.6) 81 (26.4) 105 (23.7) 134 (25.1) 40 (24.8)

Q3 158 (25.4) 36 (23.7) 147 (25.1) 40 (25.0) 141 (24.8) 46 (25.3) 151 (26.0) 43 (22.3) 133 (24.4) 59 (27.1) 77 (25.1) 110 (24.8) 134 (25.1) 36 (22.4)

Q4 153 (24.6) 40 (26.3) 146 (25.0) 40 (25.0) 143 (25.2) 44 (24.2) 135 (23.2) 58 (30.1) 136 (25.0) 54 (24.8) 75 (24.4) 112 (25.3) 133 (24.9) 43 (26.7)

MIP1B

Q1 162 (26.0) 31 (20.4) 141 (24.1) 44 (27.5) 145 (25.5) 43 (23.6) 153 (26.3) 40 (20.7) 144 (26.5) 47 (21.6) 81 (26.4) 107 (24.2) 141 (26.4) 37 (23.0)

Q2 152 (24.4) 42 (27.6) 149 (25.5) 39 (24.4) 139 (24.5) 50 (27.5) 142 (24.4) 52 (26.9) 139 (25.6) 52 (23.9) 78 (25.4) 112 (25.3) 134 (25.1) 42 (26.1)

Q3 149 (24.0) 45 (29.6) 147 (25.1) 40 (25.0) 140 (24.6) 47 (25.8) 143 (24.6) 51 (26.4) 133 (24.4) 58 (26.6) 71 (23.1) 115 (26.0) 128 (24.0) 41 (25.5)

Q4 159 (25.6) 34 (22.4) 148 (25.3) 37 (23.1) 144 (25.4) 42 (23.1) 143 (24.6) 50 (25.9) 128 (23.5) 61 (28.0) 77 (25.1) 109 (24.6) 131 (24.5) 41 (25.5)

MIP1D

Q1 155 (24.9) 38 (25.0) 145 (24.8) 38 (23.8) 150 (26.4) 37 (20.3) 147 (25.3) 46 (23.8) 139 (25.6) 53 (24.3) 90 (29.3) 97 (21.9) 137 (25.7) 38 (23.6)

Q2 161 (25.9) 33 (21.7) 154 (26.3) 34 (21.2) 148 (26.1) 43 (23.6) 154 (26.5) 40 (20.7) 137 (25.2) 52 (23.9) 67 (21.8) 124 (28.0) 135 (25.3) 41 (25.5)

Q3 156 (25.1) 38 (25.0) 144 (24.6) 45 (28.1) 134 (23.6) 53 (29.1) 141 (24.3) 53 (27.5) 132 (24.3) 59 (27.1) 83 (27.0) 103 (23.3) 130 (24.3) 39 (24.2)

Q4 150 (24.1) 43 (28.3) 142 (24.3) 43 (26.9) 136 (23.9) 49 (26.9) 139 (23.9) 54 (28.0) 136 (25.0) 54 (24.8) 67 (21.8) 119 (26.9) 132 (24.7) 43 (26.7)

SAA

Q1 173 (27.9) 20 (13.2) 155 (26.5) 32 (20.1) 160 (28.3) 29 (15.9) 159 (27.5) 34 (17.6) 152 (28.0) 38 (17.5) 82 (26.7) 108 (24.5) 144 (27.0) 29 (18.1)

Q2 151 (24.3) 42 (27.8) 147 (25.1) 41 (25.8) 132 (23.3) 53 (29.1) 142 (24.5) 51 (26.4) 138 (25.4) 52 (24.0) 78 (25.4) 106 (24.0) 132 (24.8) 39 (24.4)

Q3 147 (23.7) 46 (30.5) 138 (23.6) 46 (28.9) 140 (24.7) 47 (25.8) 133 (23.0) 60 (31.1) 133 (24.5) 55 (25.3) 79 (25.7) 107 (24.3) 129 (24.2) 45 (28.1)

Q4 150 (24.2) 43 (28.5) 145 (24.8) 40 (25.2) 134 (23.7) 53 (29.1) 145 (25.0) 48 (24.9) 120 (22.1) 72 (33.2) 68 (22.1) 120 (27.2) 128 (24.0) 47 (29.4)

SAP

Q1 167 (26.9) 26 (17.2) 155 (26.5) 30 (18.9) 160 (28.3) 26 (14.3) 139 (24.0) 54 (28.0) 144 (26.5) 45 (20.7) 90 (29.3) 96 (21.8) 142 (26.6) 29 (18.1)

Q2 156 (25.1) 37 (24.5) 144 (24.6) 39 (24.5) 140 (24.7) 50 (27.5) 149 (25.7) 44 (22.8) 140 (25.8) 50 (23.0) 76 (24.8) 114 (25.9) 137 (25.7) 40 (25.0)

Q3 152 (24.5) 41 (27.2) 149 (25.5) 37 (23.3) 143 (25.3) 44 (24.2) 142 (24.5) 51 (26.4) 119 (21.9) 71 (32.7) 76 (24.8) 112 (25.4) 137 (25.7) 33 (20.6)

Q4 146 (23.5) 47 (31.1) 137 (23.4) 53 (33.3) 123 (21.7) 62 (34.1) 149 (25.7) 44 (22.8) 140 (25.8) 51 (23.5) 65 (21.2) 119 (27.0) 117 (22.0) 58 (36.2)

SCF

Q1 160 (25.7) 33 (21.7) 151 (25.8) 33 (20.6) 150 (26.4) 39 (21.4) 153 (26.3) 40 (20.7) 132 (24.3) 56 (25.7) 86 (28.0) 102 (23.0) 132 (24.7) 45 (28.0)

Q2 161 (25.9) 33 (21.7) 148 (25.3) 38 (23.8) 150 (26.4) 36 (19.8) 150 (25.8) 44 (22.8) 148 (27.2) 45 (20.6) 80 (26.1) 107 (24.2) 136 (25.5) 39 (24.2)

Q3 160 (25.7) 34 (22.4) 155 (26.5) 33 (20.6) 142 (25.0) 47 (25.8) 152 (26.2) 42 (21.8) 134 (24.6) 58 (26.6) 78 (25.4) 111 (25.1) 133 (24.9) 42 (26.1)

Q4 141 (22.7) 52 (34.2) 131 (22.4) 56 (35.0) 126 (22.2) 60 (33.0) 126 (21.7) 67 (34.7) 130 (23.9) 59 (27.1) 63 (20.5) 123 (27.8) 133 (24.9) 35 (21.7)

SDF1AB

Q1 136 (21.9) 57 (37.5) 153 (26.2) 30 (18.8) 117 (20.6) 70 (38.5) 123 (21.2) 70 (36.3) 133 (24.4) 59 (27.1) 74 (24.1) 113 (25.5) 133 (24.9) 41 (25.5)

Q2 151 (24.3) 43 (28.3) 142 (24.3) 46 (28.7) 136 (23.9) 51 (28.0) 147 (25.3) 47 (24.4) 123 (22.6) 67 (30.7) 74 (24.1) 113 (25.5) 131 (24.5) 46 (28.6)

Q3 161 (25.9) 33 (21.7) 157 (26.8) 32 (20.0) 151 (26.6) 37 (20.3) 151 (26.0) 43 (22.3) 135 (24.8) 54 (24.8) 82 (26.7) 107 (24.2) 122 (22.8) 46 (28.6)

Q4 174 (28.0) 19 (12.5) 133 (22.7) 52 (32.5) 164 (28.9) 24 (13.2) 160 (27.5) 33 (17.1) 153 (28.1) 38 (17.4) 77 (25.1) 110 (24.8) 148 (27.7) 28 (17.4)

SEGFR

Q1 133 (25.3) 31 (23.8) 121 (24.8) 35 (24.8) 132 (27.3) 30 (19.5) 117 (23.8) 47 (28.7) 116 (25.2) 47 (25.5) 73 (28.6) 90 (23.6) 129 (28.1) 24 (18.0)

Q2 129 (24.5) 35 (26.9) 124 (25.4) 35 (24.8) 111 (23.0) 48 (31.2) 120 (24.4) 44 (26.8) 115 (24.9) 45 (24.5) 50 (19.6) 108 (28.3) 111 (24.2) 32 (24.1)

Q3 131 (24.9) 33 (25.4) 120 (24.6) 35 (24.8) 116 (24.0) 43 (27.9) 129 (26.2) 35 (21.3) 116 (25.2) 46 (25.0) 67 (26.3) 92 (24.1) 107 (23.3) 40 (30.1)

Q4 133 (25.3) 31 (23.8) 123 (25.2) 36 (25.5) 124 (25.7) 33 (21.4) 126 (25.6) 38 (23.2) 114 (24.7) 46 (25.0) 65 (25.5) 92 (24.1) 112 (24.4) 37 (27.8)

SGP130

Q1 138 (26.2) 26 (20.0) 133 (27.3) 25 (17.7) 129 (26.7) 33 (21.4) 125 (25.4) 39 (23.8) 114 (24.7) 49 (26.6) 79 (31.0) 83 (21.7) 124 (27.0) 31 (23.3)

Q2 129 (24.5) 35 (26.9) 127 (26.0) 31 (22.0) 120 (24.8) 40 (26.0) 121 (24.6) 43 (26.2) 122 (26.5) 38 (20.7) 58 (22.7) 103 (27.0) 117 (25.5) 27 (20.3)

Q3 134 (25.5) 30 (23.1) 115 (23.6) 43 (30.5) 118 (24.4) 40 (26.0) 126 (25.6) 38 (23.2) 114 (24.7) 47 (25.5) 59 (23.1) 99 (25.9) 110 (24.0) 34 (25.6)

Q4 125 (23.8) 39 (30.0) 113 (23.2) 42 (29.8) 116 (24.0) 41 (26.6) 120 (24.4) 44 (26.8) 111 (24.1) 50 (27.2) 59 (23.1) 97 (25.4) 108 (23.5) 41 (30.8)

SILRII

Q1 130 (24.7) 35 (26.9) 119 (24.4) 35 (24.8) 123 (25.5) 37 (24.0) 115 (23.4) 50 (30.5) 121 (26.2) 40 (21.7) 66 (25.9) 94 (24.6) 127 (27.7) 24 (18.0)

Q2 135 (25.7) 28 (21.5) 121 (24.8) 34 (24.1) 120 (24.8) 35 (22.7) 122 (24.8) 41 (25.0) 116 (25.2) 45 (24.5) 69 (27.1) 87 (22.8) 116 (25.3) 28 (21.1)

Q3 133 (25.3) 31 (23.8) 125 (25.6) 34 (24.1) 127 (26.3) 34 (22.1) 121 (24.6) 43 (26.2) 113 (24.5) 48 (26.1) 58 (22.7) 103 (27.0) 115 (25.1) 33 (24.8)

Q4 128 (24.3) 36 (27.7) 123 (25.2) 38 (27.0) 113 (23.4) 48 (31.2) 134 (27.2) 30 (18.3) 111 (24.1) 51 (27.7) 62 (24.3) 98 (25.7) 101 (22.0) 48 (36.1)

SIL4R

Q1 130 (24.7) 34 (26.2) 125 (25.6) 31 (22.0) 122 (25.3) 36 (23.4) 124 (25.2) 40 (24.4) 112 (24.3) 49 (26.6) 56 (22.0) 103 (27.0) 111 (24.2) 37 (27.8)

Q2 133 (25.3) 31 (23.8) 121 (24.8) 33 (23.4) 116 (24.0) 42 (27.3) 130 (26.4) 34 (20.7) 119 (25.8) 40 (21.7) 62 (24.3) 95 (24.9) 115 (25.1) 32 (24.1)

Q3 133 (25.3) 32 (24.6) 119 (24.4) 39 (27.7) 121 (25.1) 40 (26.0) 120 (24.4) 45 (27.4) 115 (24.9) 48 (26.1) 75 (29.4) 86 (22.5) 109 (23.7) 36 (27.1)

Q4 130 (24.7) 33 (25.4) 123 (25.2) 38 (27.0) 124 (25.7) 36 (23.4) 118 (24.0) 45 (27.4) 115 (24.9) 47 (25.5) 62 (24.3) 98 (25.7) 124 (27.0) 28 (21.1)

SIL6R

Q1 139 (26.4) 25 (19.2) 130 (26.6) 29 (20.6) 134 (27.7) 26 (16.9) 132 (26.8) 32 (19.5) 115 (24.9) 47 (25.5) 66 (25.9) 94 (24.6) 119 (25.9) 32 (24.1)

Q2 130 (24.7) 34 (26.2) 131 (26.8) 24 (17.0) 123 (25.5) 38 (24.7) 122 (24.8) 42 (25.6) 114 (24.7) 49 (26.6) 60 (23.5) 101 (26.4) 111 (24.2) 34 (25.6)

Q3 128 (24.3) 36 (27.7) 121 (24.8) 36 (25.5) 119 (24.6) 39 (25.3) 121 (24.6) 43 (26.2) 113 (24.5) 48 (26.1) 66 (25.9) 92 (24.1) 118 (25.7) 36 (27.1)

Q4 129 (24.5) 35 (26.9) 106 (21.7) 52 (36.9) 107 (22.2) 51 (33.1) 117 (23.8) 47 (28.7) 119 (25.8) 40 (21.7) 63 (24.7) 95 (24.9) 111 (24.2) 31 (23.3)

STNFRII

Q1 139 (26.4) 25 (19.2) 131 (26.8) 30 (21.3) 128 (26.5) 31 (20.1) 133 (27.0) 31 (18.9) 120 (26.0) 42 (22.8) 67 (26.3) 92 (24.1) 116 (25.3) 36 (27.1)

Q2 132 (25.1) 32 (24.6) 127 (26.0) 30 (21.3) 122 (25.3) 40 (26.0) 131 (26.6) 33 (20.1) 112 (24.3) 51 (27.7) 69 (27.1) 93 (24.3) 114 (24.8) 31 (23.3)

Q3 126 (24.0) 38 (29.2) 114 (23.4) 40 (28.4) 113 (23.4) 44 (28.6) 121 (24.6) 43 (26.2) 115 (24.9) 44 (23.9) 55 (21.6) 102 (26.7) 112 (24.4) 36 (27.1)

Q4 129 (24.5) 35 (26.9) 116 (23.8) 41 (29.1) 120 (24.8) 39 (25.3) 107 (21.7) 57 (34.8) 114 (24.7) 47 (25.5) 64 (25.1) 95 (24.9) 117 (25.5) 30 (22.6)

STNFRI

Q1 138 (26.2) 26 (20.0) 125 (25.6) 32 (22.7) 132 (27.3) 25 (16.2) 128 (26.0) 36 (22.0) 121 (26.2) 40 (21.7) 65 (25.5) 92 (24.1) 117 (25.5) 30 (22.6)

Q2 128 (24.3) 36 (27.7) 126 (25.8) 27 (19.1) 118 (24.4) 42 (27.3) 124 (25.2) 40 (24.4) 116 (25.2) 44 (23.9) 57 (22.4) 104 (27.2) 104 (22.7) 41 (30.8)

Q3 129 (24.5) 35 (26.9) 120 (24.6) 40 (28.4) 119 (24.6) 40 (26.0) 119 (24.2) 45 (27.4) 114 (24.7) 50 (27.2) 62 (24.3) 96 (25.1) 117 (25.5) 32 (24.1)

Q4 131 (24.9) 33 (25.4) 117 (24.0) 42 (29.8) 114 (23.6) 47 (30.5) 121 (24.6) 43 (26.2) 110 (23.9) 50 (27.2) 71 (27.8) 90 (23.6) 121 (26.4) 30 (22.6)

SVEGFR2

Q1 132 (25.1) 33 (25.4) 126 (25.8) 32 (22.7) 132 (27.3) 29 (18.8) 118 (24.0) 47 (28.7) 114 (24.7) 49 (26.6) 62 (24.3) 100 (26.2) 124 (27.0) 29 (21.8)

Q2 132 (25.1) 32 (24.6) 125 (25.6) 31 (22.0) 121 (25.1) 41 (26.6) 129 (26.2) 35 (21.3) 123 (26.7) 38 (20.7) 63 (24.7) 99 (25.9) 112 (24.4) 38 (28.6)

Q3 133 (25.3) 31 (23.8) 123 (25.2) 36 (25.5) 115 (23.8) 44 (28.6) 124 (25.2) 40 (24.4) 117 (25.4) 44 (23.9) 57 (22.4) 101 (26.4) 111 (24.2) 31 (23.3)

Q4 129 (24.5) 34 (26.2) 114 (23.4) 42 (29.8) 115 (23.8) 40 (26.0) 121 (24.6) 42 (25.6) 107 (23.2) 53 (28.8) 73 (28.6) 82 (21.5) 112 (24.4) 35 (26.3)

SVEGFR3

Q1 134 (25.5) 31 (23.8) 129 (26.4) 28 (19.9) 133 (27.5) 30 (19.5) 134 (27.2) 31 (18.9) 115 (24.9) 49 (26.6) 68 (26.7) 95 (24.9) 115 (25.1) 38 (28.6)

Q2 136 (25.9) 27 (20.8) 122 (25.0) 36 (25.5) 132 (27.3) 26 (16.9) 122 (24.8) 41 (25.0) 117 (25.4) 42 (22.8) 67 (26.3) 91 (23.8) 116 (25.3) 30 (22.6)

Q3 134 (25.5) 30 (23.1) 121 (24.8) 36 (25.5) 113 (23.4) 46 (29.9) 124 (25.2) 40 (24.4) 121 (26.2) 41 (22.3) 52 (20.4) 107 (28.0) 120 (26.1) 25 (18.8)

Q4 122 (23.2) 42 (32.3) 116 (23.8) 41 (29.1) 105 (21.7) 52 (33.8) 112 (22.8) 52 (31.7) 108 (23.4) 52 (28.3) 68 (26.7) 89 (23.3) 108 (23.5) 40 (30.1)

TARC

Q1 152 (24.4) 41 (27.0) 148 (25.3) 38 (23.8) 136 (23.9) 49 (26.9) 137 (23.6) 56 (29.0) 130 (23.9) 61 (28.0) 74 (24.1) 112 (25.3) 130 (24.3) 40 (24.8)

Q2 144 (23.2) 50 (32.9) 140 (23.9) 44 (27.5) 127 (22.4) 59 (32.4) 144 (24.8) 50 (25.9) 137 (25.2) 56 (25.7) 72 (23.5) 114 (25.7) 124 (23.2) 47 (29.2)

Q3 155 (24.9) 39 (25.7) 149 (25.5) 36 (22.5) 141 (24.8) 49 (26.9) 145 (25.0) 49 (25.4) 136 (25.0) 55 (25.2) 73 (23.8) 117 (26.4) 139 (26.0) 41 (25.5)

Q4 171 (27.5) 22 (14.5) 148 (25.3) 42 (26.2) 164 (28.9) 25 (13.7) 155 (26.7) 38 (19.7) 141 (25.9) 46 (21.1) 88 (28.7) 100 (22.6) 141 (26.4) 33 (20.5)

TGFA

Q1 152 (24.4) 41 (27.0) 152 (26.0) 37 (23.1) 143 (25.2) 45 (24.7) 142 (24.4) 51 (26.4) 140 (25.7) 50 (22.9) 73 (23.8) 116 (26.2) 137 (25.7) 45 (28.0)

Q2 150 (24.1) 44 (28.9) 132 (22.6) 51 (31.9) 136 (23.9) 50 (27.5) 146 (25.1) 48 (24.9) 125 (23.0) 66 (30.3) 72 (23.5) 113 (25.5) 132 (24.7) 38 (23.6)

Q3 164 (26.4) 32 (21.1) 152 (26.0) 36 (22.5) 148 (26.1) 45 (24.7) 158 (27.2) 38 (19.7) 147 (27.0) 47 (21.6) 84 (27.4) 109 (24.6) 135 (25.3) 36 (22.4)

Q4 156 (25.1) 35 (23.0) 149 (25.5) 36 (22.5) 141 (24.8) 42 (23.1) 135 (23.2) 56 (29.0) 132 (24.3) 55 (25.2) 78 (25.4) 105 (23.7) 130 (24.3) 42 (26.1)

TNFA

Q1 165 (26.5) 28 (18.4) 153 (26.2) 38 (23.8) 144 (25.4) 41 (22.5) 151 (26.0) 42 (21.8) 153 (28.1) 40 (18.3) 87 (28.3) 99 (22.3) 141 (26.4) 37 (23.0)

Q2 157 (25.2) 37 (24.3) 141 (24.1) 40 (25.0) 141 (24.8) 48 (26.4) 146 (25.1) 48 (24.9) 136 (25.0) 54 (24.8) 73 (23.8) 115 (26.0) 136 (25.5) 37 (23.0)

Q3 148 (23.8) 46 (30.3) 141 (24.1) 43 (26.9) 137 (24.1) 52 (28.6) 147 (25.3) 47 (24.4) 135 (24.8) 57 (26.1) 76 (24.8) 113 (25.5) 129 (24.2) 45 (28.0)

Q4 152 (24.4) 41 (27.0) 150 (25.6) 39 (24.4) 146 (25.7) 41 (22.5) 137 (23.6) 56 (29.0) 120 (22.1) 67 (30.7) 71 (23.1) 116 (26.2) 128 (24.0) 42 (26.1)

TPO

Q1 155 (24.9) 38 (25.0) 155 (26.5) 32 (20.0) 142 (25.0) 45 (24.7) 151 (26.0) 42 (21.8) 125 (23.0) 67 (30.7) 74 (24.1) 112 (25.3) 122 (22.8) 52 (32.3)

Q2 161 (25.9) 33 (21.7) 141 (24.1) 45 (28.1) 151 (26.6) 41 (22.5) 153 (26.3) 41 (21.2) 139 (25.6) 49 (22.5) 90 (29.3) 103 (23.3) 136 (25.5) 41 (25.5)

Q3 150 (24.1) 45 (29.6) 149 (25.5) 37 (23.1) 134 (23.6) 53 (29.1) 143 (24.6) 52 (26.9) 137 (25.2) 55 (25.2) 72 (23.5) 115 (26.0) 130 (24.3) 36 (22.4)

Q4 156 (25.1) 36 (23.7) 140 (23.9) 46 (28.7) 141 (24.8) 43 (23.6) 134 (23.1) 58 (30.1) 143 (26.3) 47 (21.6) 71 (23.1) 113 (25.5) 146 (27.3) 32 (19.9)

TRAIL

Q1 167 (26.8) 26 (17.1) 142 (24.3) 40 (25.0) 158 (27.8) 30 (16.5) 147 (25.3) 46 (23.8) 151 (27.8) 38 (17.4) 79 (25.7) 111 (25.1) 133 (24.9) 37 (23.0)

Q2 157 (25.2) 37 (24.3) 155 (26.5) 32 (20.0) 143 (25.2) 46 (25.3) 150 (25.8) 44 (22.8) 143 (26.3) 49 (22.5) 79 (25.7) 109 (24.6) 135 (25.3) 42 (26.1)

Q3 155 (24.9) 39 (25.7) 142 (24.3) 45 (28.1) 140 (24.6) 49 (26.9) 149 (25.6) 45 (23.3) 137 (25.2) 54 (24.8) 81 (26.4) 108 (24.4) 131 (24.5) 43 (26.7)

Q4 143 (23.0) 50 (32.9) 146 (25.0) 43 (26.9) 127 (22.4) 57 (31.3) 135 (23.2) 58 (30.1) 113 (20.8) 77 (35.3) 68 (22.1) 115 (26.0) 135 (25.3) 39 (24.2)

TSLP

Q1 539 (86.7) 132 (86.8) 507 (86.7) 140 (87.5) 495 (87.1) 154 (84.6) 504 (86.7) 167 (86.5) 476 (87.5) 184 (84.4) 263 (85.7) 387 (87.4) 462 (86.5) 137 (85.1)

Q2 83 (13.3) 20 (13.2) 78 (13.3) 20 (12.5) 73 (12.9) 28 (15.4) 77 (13.3) 26 (13.5) 68 (12.5) 34 (15.6) 44 (14.3) 56 (12.6) 72 (13.5) 24 (14.9)

VEGF

Q1 232 (37.3) 49 (32.2) 212 (36.2) 61 (38.1) 209 (36.8) 65 (35.7) 219 (37.7) 62 (32.1) 197 (36.2) 77 (35.3) 109 (35.5) 164 (37.0) 190 (35.6) 57 (35.4)

Q2 128 (20.6) 36 (23.7) 126 (21.5) 30 (18.8) 117 (20.6) 44 (24.2) 116 (20.0) 48 (24.9) 115 (21.1) 47 (21.6) 72 (23.5) 89 (20.1) 113 (21.2) 35 (21.7)

Q3 129 (20.7) 36 (23.7) 130 (22.2) 30 (18.8) 119 (21.0) 40 (22.0) 125 (21.5) 40 (20.7) 111 (20.4) 54 (24.8) 65 (21.2) 94 (21.2) 115 (21.5) 38 (23.6)

Q4 133 (21.4) 31 (20.4) 117 (20.0) 39 (24.4) 123 (21.7) 33 (18.1) 121 (20.8) 43 (22.3) 121 (22.2) 40 (18.3) 61 (19.9) 96 (21.7) 116 (21.7) 31 (19.3)

FRACTALKINE

Q1 131 (24.8) 32 (25.6) 123 (24.9) 34 (25.0) 118 (24.3) 42 (28.4) 130 (26.3) 33 (20.6) 115 (25.3) 46 (24.2) 54 (20.4) 106 (28.7) 109 (24.3) 37 (27.0)

Q2 130 (24.6) 34 (27.2) 113 (22.9) 44 (32.4) 118 (24.3) 41 (27.7) 125 (25.3) 39 (24.4) 121 (26.6) 41 (21.6) 64 (24.2) 95 (25.7) 104 (23.2) 39 (28.5)

Q3 145 (27.4) 19 (15.2) 132 (26.8) 28 (20.6) 128 (26.3) 28 (18.9) 128 (25.9) 36 (22.5) 112 (24.6) 49 (25.8) 73 (27.5) 83 (22.5) 125 (27.8) 25 (18.2)

Q4 123 (23.3) 40 (32.0) 125 (25.4) 30 (22.1) 122 (25.1) 37 (25.0) 111 (22.5) 52 (32.5) 107 (23.5) 54 (28.4) 74 (27.9) 85 (23.0) 111 (24.7) 36 (26.3)

GMCSF

Q1 133 (25.0) 31 (25.0) 127 (25.6) 28 (20.9) 120 (24.5) 42 (28.6) 131 (26.4) 33 (20.8) 116 (25.4) 47 (24.9) 61 (22.8) 101 (27.4) 112 (24.9) 38 (27.7)

Q2 125 (23.5) 40 (32.3) 120 (24.1) 42 (31.3) 123 (25.2) 37 (25.2) 116 (23.3) 49 (30.8) 112 (24.5) 49 (25.9) 62 (23.2) 98 (26.6) 104 (23.2) 43 (31.4)

Q3 129 (24.2) 34 (27.4) 127 (25.6) 32 (23.9) 118 (24.1) 38 (25.9) 125 (25.2) 38 (23.9) 111 (24.3) 50 (26.5) 59 (22.1) 97 (26.3) 121 (26.9) 26 (19.0)

Q4 145 (27.3) 19 (15.3) 123 (24.7) 32 (23.9) 128 (26.2) 30 (20.4) 125 (25.2) 39 (24.5) 118 (25.8) 43 (22.8) 85 (31.8) 73 (19.8) 112 (24.9) 30 (21.9)

IL10

Q1 237 (44.5) 49 (40.5) 221 (44.6) 56 (42.4) 219 (44.8) 61 (42.4) 226 (45.5) 60 (38.5) 206 (45.2) 78 (41.7) 108 (40.8) 173 (47.0) 190 (42.5) 65 (47.8)

Q2 98 (18.4) 24 (19.8) 94 (19.0) 27 (20.5) 88 (18.0) 29 (20.1) 92 (18.5) 30 (19.2) 87 (19.1) 34 (18.2) 45 (17.0) 72 (19.6) 86 (19.2) 20 (14.7)

Q3 98 (18.4) 25 (20.7) 95 (19.2) 24 (18.2) 92 (18.8) 27 (18.8) 93 (18.7) 30 (19.2) 81 (17.8) 39 (20.9) 56 (21.1) 63 (17.1) 88 (19.7) 26 (19.1)

Q4 99 (18.6) 23 (19.0) 86 (17.3) 25 (18.9) 90 (18.4) 27 (18.8) 86 (17.3) 36 (23.1) 82 (18.0) 36 (19.3) 56 (21.1) 60 (16.3) 83 (18.6) 25 (18.4)

IL12P70

Q1 131 (24.7) 32 (26.4) 125 (25.3) 34 (25.6) 120 (24.6) 41 (28.3) 134 (27.0) 29 (18.6) 114 (25.0) 48 (25.8) 56 (21.1) 104 (28.3) 110 (24.6) 37 (27.4)

Q2 138 (26.0) 27 (22.3) 118 (23.9) 38 (28.6) 119 (24.4) 41 (28.3) 127 (25.6) 38 (24.4) 125 (27.4) 37 (19.9) 68 (25.7) 92 (25.1) 114 (25.4) 30 (22.2)

Q3 125 (23.5) 36 (29.8) 121 (24.5) 32 (24.1) 117 (24.0) 36 (24.8) 112 (22.6) 49 (31.4) 109 (23.9) 48 (25.8) 69 (26.0) 85 (23.2) 109 (24.3) 36 (26.7)

Q4 137 (25.8) 26 (21.5) 130 (26.3) 29 (21.8) 131 (26.9) 27 (18.6) 123 (24.8) 40 (25.6) 108 (23.7) 53 (28.5) 72 (27.2) 86 (23.4) 115 (25.7) 32 (23.7)

IL13

Q1 164 (30.8) 41 (33.1) 154 (31.0) 43 (32.1) 147 (30.1) 54 (36.5) 165 (33.2) 40 (25.2) 137 (29.9) 63 (33.5) 73 (27.3) 129 (35.0) 131 (29.2) 49 (35.5)

Q2 120 (22.6) 29 (23.4) 105 (21.1) 36 (26.9) 109 (22.3) 39 (26.4) 113 (22.7) 36 (22.6) 115 (25.1) 33 (17.6) 60 (22.5) 88 (23.8) 108 (24.1) 26 (18.8)

Q3 124 (23.3) 28 (22.6) 126 (25.4) 22 (16.4) 114 (23.4) 29 (19.6) 107 (21.5) 45 (28.3) 101 (22.1) 49 (26.1) 69 (25.8) 73 (19.8) 101 (22.5) 39 (28.3)

Q4 124 (23.3) 26 (21.0) 112 (22.5) 33 (24.6) 118 (24.2) 26 (17.6) 112 (22.5) 38 (23.9) 105 (22.9) 43 (22.9) 65 (24.3) 79 (21.4) 109 (24.3) 24 (17.4)

IL17A

Q1 136 (25.5) 29 (23.6) 123 (24.7) 35 (26.3) 119 (24.3) 42 (28.6) 128 (25.8) 37 (23.3) 122 (26.6) 40 (21.3) 56 (21.0) 104 (28.2) 109 (24.3) 37 (27.0)

Q2 124 (23.3) 39 (31.7) 120 (24.1) 35 (26.3) 111 (22.7) 48 (32.7) 126 (25.4) 37 (23.3) 112 (24.5) 49 (26.1) 64 (24.0) 95 (25.7) 107 (23.8) 41 (29.9)

Q3 136 (25.5) 28 (22.8) 130 (26.1) 31 (23.3) 127 (26.0) 32 (21.8) 127 (25.6) 37 (23.3) 109 (23.8) 53 (28.2) 85 (31.8) 74 (20.1) 120 (26.7) 25 (18.2)

Q4 137 (25.7) 27 (22.0) 125 (25.1) 32 (24.1) 132 (27.0) 25 (17.0) 116 (23.3) 48 (30.2) 115 (25.1) 46 (24.5) 62 (23.2) 96 (26.0) 113 (25.2) 34 (24.8)

IL23

Q1 135 (25.4) 27 (22.7) 119 (24.1) 37 (28.0) 119 (24.3) 40 (28.2) 137 (27.6) 25 (16.1) 114 (25.0) 47 (25.4) 62 (23.6) 96 (26.1) 108 (24.1) 36 (26.9)

Q2 123 (23.1) 40 (33.6) 126 (25.5) 33 (25.0) 118 (24.1) 43 (30.3) 119 (24.0) 44 (28.4) 114 (25.0) 45 (24.3) 63 (24.0) 98 (26.6) 107 (23.9) 43 (32.1)

Q3 136 (25.6) 27 (22.7) 128 (25.9) 29 (22.0) 126 (25.8) 30 (21.1) 126 (25.4) 37 (23.9) 118 (25.9) 43 (23.2) 65 (24.7) 92 (25.0) 116 (25.9) 25 (18.7)

Q4 138 (25.9) 25 (21.0) 121 (24.5) 33 (25.0) 126 (25.8) 29 (20.4) 114 (23.0) 49 (31.6) 110 (24.1) 50 (27.0) 73 (27.8) 82 (22.3) 117 (26.1) 30 (22.4)

IL4

Q1 429 (80.8) 93 (76.9) 397 (80.2) 109 (82.0) 390 (79.9) 120 (83.3) 413 (83.3) 109 (69.9) 376 (82.6) 138 (73.8) 210 (79.5) 300 (81.5) 360 (80.2) 105 (77.8)

Q2 102 (19.2) 28 (23.1) 98 (19.8) 24 (18.0) 98 (20.1) 24 (16.7) 83 (16.7) 47 (30.1) 79 (17.4) 49 (26.2) 54 (20.5) 68 (18.5) 89 (19.8) 30 (22.2)

IL5

Q1 130 (24.4) 33 (27.0) 120 (24.1) 38 (28.6) 115 (23.5) 45 (30.8) 129 (26.0) 34 (21.5) 118 (25.8) 44 (23.4) 53 (19.9) 106 (28.8) 111 (24.8) 36 (26.3)

Q2 131 (24.6) 34 (27.9) 125 (25.2) 33 (24.8) 113 (23.1) 47 (32.2) 126 (25.4) 39 (24.7) 112 (24.5) 51 (27.1) 61 (22.8) 100 (27.2) 105 (23.4) 36 (26.3)

Q3 131 (24.6) 32 (26.2) 120 (24.1) 36 (27.1) 131 (26.8) 25 (17.1) 124 (24.9) 39 (24.7) 115 (25.2) 42 (22.3) 69 (25.8) 87 (23.6) 114 (25.4) 36 (26.3)

Q4 141 (26.5) 23 (18.9) 132 (26.6) 26 (19.5) 130 (26.6) 29 (19.9) 118 (23.7) 46 (29.1) 112 (24.5) 51 (27.1) 84 (31.5) 75 (20.4) 118 (26.3) 29 (21.2)

IL7

Q1 140 (26.8) 23 (20.7) 120 (25.1) 38 (28.8) 125 (26.2) 32 (23.5) 128 (26.3) 35 (23.6) 114 (25.4) 45 (25.6) 67 (25.7) 90 (25.5) 108 (24.6) 37 (28.2)

Q2 124 (23.7) 33 (29.7) 117 (24.4) 33 (25.0) 110 (23.0) 44 (32.4) 122 (25.1) 35 (23.6) 117 (26.1) 38 (21.6) 59 (22.6) 95 (26.9) 107 (24.4) 37 (28.2)

Q3 131 (25.0) 26 (23.4) 121 (25.3) 28 (21.2) 123 (25.7) 29 (21.3) 119 (24.5) 38 (25.7) 107 (23.8) 49 (27.8) 66 (25.3) 86 (24.4) 111 (25.3) 31 (23.7)

Q4 128 (24.5) 29 (26.1) 121 (25.3) 33 (25.0) 120 (25.1) 31 (22.8) 117 (24.1) 40 (27.0) 111 (24.7) 44 (25.0) 69 (26.4) 82 (23.2) 113 (25.7) 26 (19.8)

MIP1A

Q1 139 (26.2) 24 (19.7) 113 (22.9) 42 (31.3) 119 (24.4) 40 (27.6) 129 (26.0) 34 (21.8) 127 (27.8) 33 (17.7) 60 (22.8) 98 (26.5) 122 (27.2) 31 (22.8)

Q2 127 (23.9) 36 (29.5) 126 (25.5) 33 (24.6) 116 (23.8) 41 (28.3) 125 (25.2) 38 (24.4) 116 (25.4) 47 (25.3) 78 (29.7) 80 (21.6) 114 (25.4) 30 (22.1)

Q3 132 (24.9) 32 (26.2) 124 (25.1) 33 (24.6) 129 (26.4) 31 (21.4) 128 (25.8) 36 (23.1) 107 (23.4) 54 (29.0) 62 (23.6) 98 (26.5) 103 (22.9) 40 (29.4)

Q4 133 (25.0) 30 (24.6) 131 (26.5) 26 (19.4) 124 (25.4) 33 (22.8) 115 (23.1) 48 (30.8) 107 (23.4) 52 (28.0) 63 (24.0) 94 (25.4) 110 (24.5) 35 (25.7)

IL1B

Q1 131 (24.7) 31 (27.0) 117 (23.9) 35 (26.5) 113 (23.2) 44 (32.1) 126 (25.5) 36 (23.8) 117 (25.9) 43 (23.4) 60 (22.8) 97 (26.8) 108 (24.3) 38 (28.4)

Q2 128 (24.2) 31 (27.0) 124 (25.4) 32 (24.2) 126 (25.8) 33 (24.1) 129 (26.1) 30 (19.9) 111 (24.6) 46 (25.0) 59 (22.4) 100 (27.6) 111 (25.0) 34 (25.4)

Q3 131 (24.7) 32 (27.8) 127 (26.0) 32 (24.2) 118 (24.2) 37 (27.0) 120 (24.3) 43 (28.5) 108 (23.9) 54 (29.3) 68 (25.9) 87 (24.0) 112 (25.2) 30 (22.4)

Q4 140 (26.4) 21 (18.3) 121 (24.7) 33 (25.0) 131 (26.8) 23 (16.8) 119 (24.1) 42 (27.8) 115 (25.5) 41 (22.3) 76 (28.9) 78 (21.5) 113 (25.5) 32 (23.9)

IL21

Q1 228 (43.6) 40 (35.4) 203 (41.9) 59 (45.7) 204 (42.6) 59 (43.1) 220 (45.0) 48 (32.7) 194 (43.7) 69 (37.7) 103 (39.5) 160 (45.1) 184 (42.0) 55 (41.7)

Q2 96 (18.4) 26 (23.0) 91 (18.8) 27 (20.9) 91 (19.0) 27 (19.7) 94 (19.2) 28 (19.0) 84 (18.9) 36 (19.7) 48 (18.4) 70 (19.7) 81 (18.5) 29 (22.0)

Q3 101 (19.3) 22 (19.5) 92 (19.0) 25 (19.4) 90 (18.8) 25 (18.2) 90 (18.4) 33 (22.4) 89 (20.0) 34 (18.6) 50 (19.2) 65 (18.3) 87 (19.9) 20 (15.2)

Q4 98 (18.7) 25 (22.1) 98 (20.2) 18 (14.0) 94 (19.6) 26 (19.0) 85 (17.4) 38 (25.9) 77 (17.3) 44 (24.0) 60 (23.0) 60 (16.9) 86 (19.6) 28 (21.2)

IL6

Q1 127 (24.1) 31 (29.0) 116 (24.0) 35 (27.3) 111 (22.9) 42 (32.8) 125 (25.6) 33 (22.9) 113 (25.5) 42 (23.3) 57 (22.0) 96 (27.1) 108 (24.7) 35 (26.9)

Q2 132 (25.1) 27 (25.2) 121 (25.1) 33 (25.8) 121 (24.9) 34 (26.6) 130 (26.6) 29 (20.1) 114 (25.7) 43 (23.9) 68 (26.3) 87 (24.6) 116 (26.5) 28 (21.5)

Q3 133 (25.3) 25 (23.4) 124 (25.7) 28 (21.9) 126 (26.0) 26 (20.3) 116 (23.7) 42 (29.2) 110 (24.8) 47 (26.1) 71 (27.4) 81 (22.9) 104 (23.8) 32 (24.6)

Q4 134 (25.5) 24 (22.4) 122 (25.3) 32 (25.0) 127 (26.2) 26 (20.3) 118 (24.1) 40 (27.8) 106 (23.9) 48 (26.7) 63 (24.3) 90 (25.4) 109 (24.9) 35 (26.9)

VEGFA

Q1 88 (26.3) 15 (19.7) 82 (26.7) 17 (18.5) 89 (28.6) 12 (13.8) 86 (27.9) 17 (16.7) 75 (25.6) 28 (25.0) 43 (27.2) 59 (24.5) 71 (26.0) 25 (27.2)

Q2 82 (24.6) 20 (26.3) 75 (24.4) 24 (26.1) 76 (24.4) 21 (24.1) 75 (24.4) 27 (26.5) 69 (23.5) 32 (28.6) 38 (24.1) 60 (24.9) 70 (25.6) 23 (25.0)

Q3 84 (25.1) 19 (25.0) 78 (25.4) 23 (25.0) 79 (25.4) 21 (24.1) 76 (24.7) 27 (26.5) 71 (24.2) 28 (25.0) 38 (24.1) 61 (25.3) 65 (23.8) 23 (25.0)

Q4 80 (24.0) 22 (28.9) 72 (23.5) 28 (30.4) 67 (21.5) 33 (37.9) 71 (23.1) 31 (30.4) 78 (26.6) 24 (21.4) 39 (24.7) 61 (25.3) 67 (24.5) 21 (22.8)

CDCP1

Q1 89 (26.6) 14 (18.4) 82 (26.7) 19 (20.7) 86 (27.7) 14 (16.1) 79 (25.6) 24 (23.5) 60 (20.5) 41 (36.6) 47 (29.7) 54 (22.4) 76 (27.8) 19 (20.7)

Q2 80 (24.0) 22 (28.9) 79 (25.7) 22 (23.9) 73 (23.5) 24 (27.6) 75 (24.4) 27 (26.5) 71 (24.2) 29 (25.9) 35 (22.2) 62 (25.7) 73 (26.7) 20 (21.7)

Q3 83 (24.9) 20 (26.3) 76 (24.8) 24 (26.1) 76 (24.4) 25 (28.7) 80 (26.0) 23 (22.5) 80 (27.3) 23 (20.5) 47 (29.7) 55 (22.8) 63 (23.1) 27 (29.3)

Q4 82 (24.6) 20 (26.3) 70 (22.8) 27 (29.3) 76 (24.4) 24 (27.6) 74 (24.0) 28 (27.5) 82 (28.0) 19 (17.0) 29 (18.4) 70 (29.0) 61 (22.3) 26 (28.3)

CD244

Q1 83 (24.9) 20 (26.3) 78 (25.4) 22 (23.9) 79 (25.4) 19 (21.8) 79 (25.6) 24 (23.5) 72 (24.6) 30 (26.8) 39 (24.7) 59 (24.5) 75 (27.5) 19 (20.7)

Q2 86 (25.7) 16 (21.1) 75 (24.4) 24 (26.1) 78 (25.1) 19 (21.8) 76 (24.7) 26 (25.5) 80 (27.3) 22 (19.6) 36 (22.8) 63 (26.1) 69 (25.3) 19 (20.7)

Q3 82 (24.6) 21 (27.6) 78 (25.4) 22 (23.9) 78 (25.1) 24 (27.6) 75 (24.4) 28 (27.5) 66 (22.5) 36 (32.1) 43 (27.2) 58 (24.1) 64 (23.4) 28 (30.4)

Q4 83 (24.9) 19 (25.0) 76 (24.8) 24 (26.1) 76 (24.4) 25 (28.7) 78 (25.3) 24 (23.5) 75 (25.6) 24 (21.4) 40 (25.3) 61 (25.3) 65 (23.8) 26 (28.3)

OPG

Q1 84 (25.1) 19 (25.0) 74 (24.1) 26 (28.3) 76 (24.4) 22 (25.3) 72 (23.4) 31 (30.4) 69 (23.5) 32 (28.6) 44 (27.8) 55 (22.8) 72 (26.4) 20 (21.7)

Q2 82 (24.6) 20 (26.3) 77 (25.1) 24 (26.1) 70 (22.5) 28 (32.2) 80 (26.0) 22 (21.6) 74 (25.3) 28 (25.0) 39 (24.7) 59 (24.5) 66 (24.2) 24 (26.1)

Q3 84 (25.1) 19 (25.0) 82 (26.7) 16 (17.4) 83 (26.7) 18 (20.7) 80 (26.0) 23 (22.5) 69 (23.5) 31 (27.7) 41 (25.9) 61 (25.3) 72 (26.4) 23 (25.0)

Q4 84 (25.1) 18 (23.7) 74 (24.1) 26 (28.3) 82 (26.4) 19 (21.8) 76 (24.7) 26 (25.5) 81 (27.6) 21 (18.8) 34 (21.5) 66 (27.4) 63 (23.1) 25 (27.2)

LAPTGFB1

Q1 89 (26.6) 14 (18.4) 74 (24.1) 24 (26.1) 87 (28.0) 13 (14.9) 83 (26.9) 20 (19.6) 75 (25.6) 28 (25.0) 42 (26.6) 59 (24.5) 74 (27.1) 21 (22.8)

Q2 83 (24.9) 19 (25.0) 86 (28.0) 14 (15.2) 78 (25.1) 20 (23.0) 75 (24.4) 27 (26.5) 70 (23.9) 31 (27.7) 41 (25.9) 57 (23.7) 71 (26.0) 21 (22.8)

Q3 78 (23.4) 25 (32.9) 74 (24.1) 27 (29.3) 72 (23.2) 26 (29.9) 77 (25.0) 26 (25.5) 71 (24.2) 30 (26.8) 36 (22.8) 63 (26.1) 64 (23.4) 27 (29.3)

Q4 84 (25.1) 18 (23.7) 73 (23.8) 27 (29.3) 74 (23.8) 28 (32.2) 73 (23.7) 29 (28.4) 77 (26.3) 23 (20.5) 39 (24.7) 62 (25.7) 64 (23.4) 23 (25.0)

UPA

Q1 84 (25.1) 19 (25.0) 76 (24.8) 25 (27.2) 77 (24.8) 23 (26.4) 81 (26.3) 22 (21.6) 69 (23.5) 32 (28.6) 38 (24.1) 63 (26.1) 70 (25.6) 26 (28.3)

Q2 81 (24.3) 21 (27.6) 77 (25.1) 22 (23.9) 77 (24.8) 21 (24.1) 72 (23.4) 30 (29.4) 71 (24.2) 30 (26.8) 41 (25.9) 57 (23.7) 67 (24.5) 27 (29.3)

Q3 82 (24.6) 21 (27.6) 78 (25.4) 23 (25.0) 76 (24.4) 23 (26.4) 78 (25.3) 25 (24.5) 72 (24.6) 29 (25.9) 39 (24.7) 60 (24.9) 69 (25.3) 20 (21.7)

Q4 87 (26.0) 15 (19.7) 76 (24.8) 22 (23.9) 81 (26.0) 20 (23.0) 77 (25.0) 25 (24.5) 81 (27.6) 21 (18.8) 40 (25.3) 61 (25.3) 67 (24.5) 19 (20.7)

CST5

Q1 89 (26.6) 14 (18.4) 80 (26.1) 21 (22.8) 85 (27.3) 14 (16.1) 78 (25.3) 25 (24.5) 72 (24.6) 30 (26.8) 42 (26.6) 58 (24.1) 72 (26.4) 19 (20.7)

Q2 75 (22.5) 27 (35.5) 75 (24.4) 25 (27.2) 74 (23.8) 22 (25.3) 74 (24.0) 28 (27.5) 68 (23.2) 34 (30.4) 38 (24.1) 58 (24.1) 66 (24.2) 24 (26.1)

Q3 84 (25.1) 19 (25.0) 79 (25.7) 22 (23.9) 81 (26.0) 22 (25.3) 80 (26.0) 23 (22.5) 72 (24.6) 30 (26.8) 46 (29.1) 57 (23.7) 66 (24.2) 24 (26.1)

Q4 86 (25.7) 16 (21.1) 73 (23.8) 24 (26.1) 71 (22.8) 29 (33.3) 76 (24.7) 26 (25.5) 81 (27.6) 18 (16.1) 32 (20.3) 68 (28.2) 69 (25.3) 25 (27.2)

CD6

Q1 89 (26.6) 14 (18.4) 76 (24.8) 23 (25.0) 83 (26.7) 16 (18.4) 83 (26.9) 20 (19.6) 75 (25.6) 26 (23.2) 46 (29.1) 54 (22.4) 74 (27.1) 18 (19.6)

Q2 88 (26.3) 14 (18.4) 81 (26.4) 20 (21.7) 84 (27.0) 15 (17.2) 83 (26.9) 19 (18.6) 75 (25.6) 25 (22.3) 34 (21.5) 66 (27.4) 70 (25.6) 25 (27.2)

Q3 82 (24.6) 21 (27.6) 78 (25.4) 22 (23.9) 75 (24.1) 26 (29.9) 76 (24.7) 27 (26.5) 78 (26.6) 24 (21.4) 40 (25.3) 61 (25.3) 66 (24.2) 25 (27.2)

Q4 75 (22.5) 27 (35.5) 72 (23.5) 27 (29.3) 69 (22.2) 30 (34.5) 66 (21.4) 36 (35.3) 65 (22.2) 37 (33.0) 38 (24.1) 60 (24.9) 63 (23.1) 24 (26.1)

IL18

Q1 91 (27.2) 12 (15.8) 83 (27.0) 17 (18.5) 86 (27.7) 15 (17.2) 83 (26.9) 20 (19.6) 79 (27.0) 23 (20.5) 46 (29.1) 56 (23.2) 78 (28.6) 16 (17.4)

Q2 78 (23.4) 24 (31.6) 72 (23.5) 27 (29.3) 75 (24.1) 25 (28.7) 80 (26.0) 22 (21.6) 72 (24.6) 29 (25.9) 42 (26.6) 58 (24.1) 68 (24.9) 27 (29.3)

Q3 86 (25.7) 17 (22.4) 84 (27.4) 19 (20.7) 80 (25.7) 21 (24.1) 72 (23.4) 31 (30.4) 72 (24.6) 30 (26.8) 43 (27.2) 58 (24.1) 65 (23.8) 24 (26.1)

Q4 79 (23.7) 23 (30.3) 68 (22.1) 29 (31.5) 70 (22.5) 26 (29.9) 73 (23.7) 29 (28.4) 70 (23.9) 30 (26.8) 27 (17.1) 69 (28.6) 62 (22.7) 25 (27.2)

TNFSF14

Q1 85 (25.4) 18 (23.7) 74 (24.1) 27 (29.3) 79 (25.4) 20 (23.0) 81 (26.3) 22 (21.6) 75 (25.6) 28 (25.0) 42 (26.6) 59 (24.5) 73 (26.7) 22 (23.9)

Q2 81 (24.3) 21 (27.6) 74 (24.1) 25 (27.2) 82 (26.4) 17 (19.5) 77 (25.0) 25 (24.5) 72 (24.6) 27 (24.1) 38 (24.1) 61 (25.3) 66 (24.2) 25 (27.2)

Q3 79 (23.7) 24 (31.6) 78 (25.4) 23 (25.0) 74 (23.8) 27 (31.0) 79 (25.6) 24 (23.5) 67 (22.9) 35 (31.2) 33 (20.9) 67 (27.8) 65 (23.8) 25 (27.2)

Q4 89 (26.6) 13 (17.1) 81 (26.4) 17 (18.5) 76 (24.4) 23 (26.4) 71 (23.1) 31 (30.4) 79 (27.0) 22 (19.6) 45 (28.5) 54 (22.4) 69 (25.3) 20 (21.7)

FGF23

Q1 86 (25.7) 17 (22.4) 79 (25.7) 20 (21.7) 84 (27.0) 18 (20.7) 76 (24.7) 27 (26.5) 71 (24.2) 30 (26.8) 42 (26.6) 59 (24.5) 66 (24.2) 26 (28.3)

Q2 89 (26.6) 13 (17.1) 75 (24.4) 24 (26.1) 80 (25.7) 17 (19.5) 81 (26.3) 21 (20.6) 79 (27.0) 22 (19.6) 36 (22.8) 62 (25.7) 69 (25.3) 21 (22.8)

Q3 81 (24.3) 22 (28.9) 82 (26.7) 21 (22.8) 77 (24.8) 22 (25.3) 79 (25.6) 24 (23.5) 73 (24.9) 28 (25.0) 38 (24.1) 62 (25.7) 70 (25.6) 21 (22.8)

Q4 78 (23.4) 24 (31.6) 71 (23.1) 27 (29.3) 70 (22.5) 30 (34.5) 72 (23.4) 30 (29.4) 70 (23.9) 32 (28.6) 42 (26.6) 58 (24.1) 68 (24.9) 24 (26.1)

LIFR

Q1 81 (24.3) 22 (28.9) 75 (24.4) 24 (26.1) 73 (23.5) 27 (31.0) 73 (23.7) 30 (29.4) 77 (26.3) 26 (23.2) 43 (27.2) 58 (24.1) 76 (27.8) 19 (20.7)

Q2 86 (25.7) 16 (21.1) 78 (25.4) 20 (21.7) 76 (24.4) 22 (25.3) 78 (25.3) 24 (23.5) 72 (24.6) 28 (25.0) 43 (27.2) 55 (22.8) 71 (26.0) 18 (19.6)

Q3 88 (26.3) 15 (19.7) 79 (25.7) 23 (25.0) 84 (27.0) 17 (19.5) 79 (25.6) 24 (23.5) 70 (23.9) 31 (27.7) 42 (26.6) 59 (24.5) 77 (28.2) 15 (16.3)

Q4 79 (23.7) 23 (30.3) 75 (24.4) 25 (27.2) 78 (25.1) 21 (24.1) 78 (25.3) 24 (23.5) 74 (25.3) 27 (24.1) 30 (19.0) 69 (28.6) 49 (17.9) 40 (43.5)

FGF21

Q1 87 (26.0) 16 (21.1) 81 (26.4) 17 (18.5) 83 (26.7) 19 (21.8) 84 (27.3) 19 (18.6) 73 (24.9) 29 (25.9) 49 (31.0) 53 (22.0) 71 (26.0) 22 (23.9)

Q2 83 (24.9) 19 (25.0) 77 (25.1) 24 (26.1) 79 (25.4) 21 (24.1) 74 (24.0) 28 (27.5) 73 (24.9) 29 (25.9) 38 (24.1) 62 (25.7) 66 (24.2) 24 (26.1)

Q3 80 (24.0) 23 (30.3) 77 (25.1) 24 (26.1) 70 (22.5) 27 (31.0) 72 (23.4) 31 (30.4) 66 (22.5) 34 (30.4) 35 (22.2) 64 (26.6) 69 (25.3) 22 (23.9)

Q4 84 (25.1) 18 (23.7) 72 (23.5) 27 (29.3) 79 (25.4) 20 (23.0) 78 (25.3) 24 (23.5) 81 (27.6) 20 (17.9) 36 (22.8) 62 (25.7) 67 (24.5) 24 (26.1)

IL10RB

Q1 83 (24.9) 20 (26.3) 85 (27.7) 16 (17.4) 85 (27.3) 16 (18.4) 77 (25.0) 26 (25.5) 74 (25.3) 28 (25.0) 54 (34.2) 48 (19.9) 77 (28.2) 22 (23.9)

Q2 87 (26.0) 15 (19.7) 75 (24.4) 23 (25.0) 83 (26.7) 15 (17.2) 83 (26.9) 19 (18.6) 74 (25.3) 27 (24.1) 33 (20.9) 65 (27.0) 67 (24.5) 22 (23.9)

Q3 83 (24.9) 20 (26.3) 78 (25.4) 22 (23.9) 74 (23.8) 25 (28.7) 75 (24.4) 28 (27.5) 70 (23.9) 32 (28.6) 42 (26.6) 57 (23.7) 66 (24.2) 23 (25.0)

Q4 81 (24.3) 21 (27.6) 69 (22.5) 31 (33.7) 69 (22.2) 31 (35.6) 73 (23.7) 29 (28.4) 75 (25.6) 25 (22.3) 29 (18.4) 71 (29.5) 63 (23.1) 25 (27.2)

PDL1

Q1 85 (25.4) 18 (23.7) 81 (26.4) 18 (19.6) 81 (26.0) 21 (24.1) 81 (26.3) 22 (21.6) 74 (25.3) 28 (25.0) 44 (27.8) 59 (24.5) 76 (27.8) 19 (20.7)

Q2 81 (24.3) 21 (27.6) 84 (27.4) 18 (19.6) 78 (25.1) 18 (20.7) 78 (25.3) 24 (23.5) 69 (23.5) 33 (29.5) 41 (25.9) 55 (22.8) 63 (23.1) 22 (23.9)

Q3 85 (25.4) 18 (23.7) 75 (24.4) 25 (27.2) 78 (25.1) 23 (26.4) 72 (23.4) 31 (30.4) 73 (24.9) 28 (25.0) 43 (27.2) 58 (24.1) 71 (26.0) 24 (26.1)

Q4 83 (24.9) 19 (25.0) 67 (21.8) 31 (33.7) 74 (23.8) 25 (28.7) 77 (25.0) 25 (24.5) 77 (26.3) 23 (20.5) 30 (19.0) 69 (28.6) 63 (23.1) 27 (29.3)

BNGF

Q1 84 (25.1) 19 (25.0) 80 (26.1) 20 (21.7) 79 (25.4) 21 (24.1) 79 (25.6) 24 (23.5) 66 (22.5) 35 (31.2) 49 (31.0) 52 (21.6) 68 (24.9) 28 (30.4)

Q2 84 (25.1) 18 (23.7) 74 (24.1) 25 (27.2) 75 (24.1) 24 (27.6) 78 (25.3) 24 (23.5) 70 (23.9) 32 (28.6) 41 (25.9) 57 (23.7) 75 (27.5) 17 (18.5)

Q3 86 (25.7) 17 (22.4) 77 (25.1) 25 (27.2) 84 (27.0) 17 (19.5) 77 (25.0) 26 (25.5) 75 (25.6) 26 (23.2) 34 (21.5) 68 (28.2) 65 (23.8) 24 (26.1)

Q4 80 (24.0) 22 (28.9) 76 (24.8) 22 (23.9) 73 (23.5) 25 (28.7) 74 (24.0) 28 (27.5) 82 (28.0) 19 (17.0) 34 (21.5) 64 (26.6) 65 (23.8) 23 (25.0)

IL18R1

Q1 93 (27.8) 10 (13.2) 81 (26.4) 19 (20.7) 89 (28.6) 12 (13.8) 86 (27.9) 17 (16.7) 86 (29.4) 17 (15.2) 49 (31.0) 52 (21.6) 80 (29.3) 15 (16.3)

Q2 85 (25.4) 17 (22.4) 76 (24.8) 23 (25.0) 80 (25.7) 19 (21.8) 70 (22.7) 32 (31.4) 79 (27.0) 21 (18.8) 43 (27.2) 57 (23.7) 67 (24.5) 19 (20.7)

Q3 88 (26.3) 15 (19.7) 73 (23.8) 27 (29.3) 77 (24.8) 21 (24.1) 79 (25.6) 24 (23.5) 70 (23.9) 32 (28.6) 34 (21.5) 65 (27.0) 77 (28.2) 19 (20.7)

Q4 68 (20.4) 34 (44.7) 77 (25.1) 23 (25.0) 65 (20.9) 35 (40.2) 73 (23.7) 29 (28.4) 58 (19.8) 42 (37.5) 32 (20.3) 67 (27.8) 49 (17.9) 39 (42.4)

TRANCE

Q1 88 (26.3) 15 (19.7) 79 (25.7) 20 (21.7) 90 (28.9) 10 (11.5) 83 (26.9) 20 (19.6) 80 (27.3) 22 (19.6) 42 (26.6) 59 (24.5) 73 (26.7) 17 (18.5)

Q2 89 (26.6) 13 (17.1) 78 (25.4) 20 (21.7) 85 (27.3) 17 (19.5) 85 (27.6) 17 (16.7) 69 (23.5) 33 (29.5) 38 (24.1) 63 (26.1) 61 (22.3) 28 (30.4)

Q3 85 (25.4) 18 (23.7) 78 (25.4) 24 (26.1) 79 (25.4) 21 (24.1) 71 (23.1) 32 (31.4) 75 (25.6) 25 (22.3) 48 (30.4) 52 (21.6) 78 (28.6) 15 (16.3)

Q4 72 (21.6) 30 (39.5) 72 (23.5) 28 (30.4) 57 (18.3) 39 (44.8) 69 (22.4) 33 (32.4) 69 (23.5) 32 (28.6) 30 (19.0) 67 (27.8) 61 (22.3) 32 (34.8)

HGF

Q1 89 (26.6) 14 (18.4) 74 (24.1) 25 (27.2) 83 (26.7) 17 (19.5) 85 (27.6) 18 (17.6) 79 (27.0) 24 (21.4) 53 (33.5) 48 (19.9) 77 (28.2) 19 (20.7)

Q2 82 (24.6) 20 (26.3) 78 (25.4) 20 (21.7) 78 (25.1) 21 (24.1) 75 (24.4) 27 (26.5) 72 (24.6) 27 (24.1) 37 (23.4) 63 (26.1) 68 (24.9) 22 (23.9)

Q3 84 (25.1) 19 (25.0) 79 (25.7) 22 (23.9) 85 (27.3) 16 (18.4) 78 (25.3) 25 (24.5) 74 (25.3) 27 (24.1) 32 (20.3) 69 (28.6) 67 (24.5) 25 (27.2)

Q4 79 (23.7) 23 (30.3) 76 (24.8) 25 (27.2) 65 (20.9) 33 (37.9) 70 (22.7) 32 (31.4) 68 (23.2) 34 (30.4) 36 (22.8) 61 (25.3) 61 (22.3) 26 (28.3)

IL12B

Q1 87 (26.0) 16 (21.1) 80 (26.1) 19 (20.7) 85 (27.3) 15 (17.2) 83 (26.9) 20 (19.6) 77 (26.3) 24 (21.4) 36 (22.8) 65 (27.0) 63 (23.1) 25 (27.2)

Q2 88 (26.3) 14 (18.4) 82 (26.7) 18 (19.6) 71 (22.8) 25 (28.7) 83 (26.9) 19 (18.6) 81 (27.6) 21 (18.8) 35 (22.2) 61 (25.3) 82 (30.0) 13 (14.1)

Q3 85 (25.4) 18 (23.7) 74 (24.1) 26 (28.3) 79 (25.4) 22 (25.3) 80 (26.0) 23 (22.5) 72 (24.6) 29 (25.9) 46 (29.1) 55 (22.8) 65 (23.8) 27 (29.3)

Q4 74 (22.2) 28 (36.8) 71 (23.1) 29 (31.5) 76 (24.4) 25 (28.7) 62 (20.1) 40 (39.2) 63 (21.5) 38 (33.9) 41 (25.9) 60 (24.9) 63 (23.1) 27 (29.3)

MMP1

Q1 81 (24.3) 22 (28.9) 75 (24.4) 23 (25.0) 81 (26.0) 19 (21.8) 76 (24.7) 27 (26.5) 67 (22.9) 36 (32.1) 42 (26.6) 59 (24.5) 62 (22.7) 28 (30.4)

Q2 82 (24.6) 20 (26.3) 76 (24.8) 22 (23.9) 70 (22.5) 27 (31.0) 75 (24.4) 27 (26.5) 75 (25.6) 27 (24.1) 36 (22.8) 62 (25.7) 71 (26.0) 18 (19.6)

Q3 85 (25.4) 18 (23.7) 78 (25.4) 24 (26.1) 81 (26.0) 21 (24.1) 84 (27.3) 19 (18.6) 74 (25.3) 27 (24.1) 42 (26.6) 59 (24.5) 68 (24.9) 24 (26.1)

Q4 86 (25.7) 16 (21.1) 78 (25.4) 23 (25.0) 79 (25.4) 20 (23.0) 73 (23.7) 29 (28.4) 77 (26.3) 22 (19.6) 38 (24.1) 61 (25.3) 72 (26.4) 22 (23.9)

MMP10

Q1 77 (23.1) 26 (34.2) 77 (25.1) 23 (25.0) 77 (24.8) 25 (28.7) 74 (24.0) 29 (28.4) 66 (22.5) 36 (32.1) 43 (27.2) 60 (24.9) 70 (25.6) 23 (25.0)

Q2 84 (25.1) 18 (23.7) 82 (26.7) 18 (19.6) 79 (25.4) 19 (21.8) 76 (24.7) 26 (25.5) 70 (23.9) 31 (27.7) 35 (22.2) 63 (26.1) 62 (22.7) 29 (31.5)

Q3 88 (26.3) 15 (19.7) 75 (24.4) 24 (26.1) 78 (25.1) 21 (24.1) 79 (25.6) 24 (23.5) 75 (25.6) 26 (23.2) 37 (23.4) 62 (25.7) 71 (26.0) 21 (22.8)

Q4 85 (25.4) 17 (22.4) 73 (23.8) 27 (29.3) 77 (24.8) 22 (25.3) 79 (25.6) 23 (22.5) 82 (28.0) 19 (17.0) 43 (27.2) 56 (23.2) 70 (25.6) 19 (20.7)

CCL23

Q1 79 (23.7) 24 (31.6) 79 (25.7) 22 (23.9) 78 (25.1) 22 (25.3) 78 (25.3) 25 (24.5) 70 (23.9) 33 (29.5) 41 (25.9) 59 (24.5) 66 (24.2) 26 (28.3)

Q2 81 (24.3) 21 (27.6) 77 (25.1) 21 (22.8) 76 (24.4) 23 (26.4) 76 (24.7) 26 (25.5) 70 (23.9) 28 (25.0) 34 (21.5) 65 (27.0) 68 (24.9) 23 (25.0)

Q3 89 (26.6) 14 (18.4) 78 (25.4) 22 (23.9) 80 (25.7) 20 (23.0) 79 (25.6) 24 (23.5) 78 (26.6) 24 (21.4) 39 (24.7) 61 (25.3) 68 (24.9) 23 (25.0)

Q4 85 (25.4) 17 (22.4) 73 (23.8) 27 (29.3) 77 (24.8) 22 (25.3) 75 (24.4) 27 (26.5) 75 (25.6) 27 (24.1) 44 (27.8) 56 (23.2) 71 (26.0) 20 (21.7)

CD5

Q1 92 (27.5) 11 (14.5) 82 (26.7) 17 (18.5) 90 (28.9) 11 (12.6) 88 (28.6) 15 (14.7) 76 (25.9) 25 (22.3) 47 (29.7) 55 (22.8) 71 (26.0) 22 (23.9)

Q2 85 (25.4) 17 (22.4) 76 (24.8) 25 (27.2) 78 (25.1) 19 (21.8) 79 (25.6) 23 (22.5) 76 (25.9) 25 (22.3) 42 (26.6) 56 (23.2) 73 (26.7) 17 (18.5)

Q3 83 (24.9) 20 (26.3) 83 (27.0) 19 (20.7) 75 (24.1) 26 (29.9) 77 (25.0) 26 (25.5) 72 (24.6) 30 (26.8) 31 (19.6) 69 (28.6) 67 (24.5) 27 (29.3)

Q4 74 (22.2) 28 (36.8) 66 (21.5) 31 (33.7) 68 (21.9) 31 (35.6) 64 (20.8) 38 (37.3) 69 (23.5) 32 (28.6) 38 (24.1) 61 (25.3) 62 (22.7) 26 (28.3)

FLT3L

Q1 85 (25.4) 18 (23.7) 80 (26.1) 20 (21.7) 75 (24.1) 23 (26.4) 75 (24.4) 28 (27.5) 71 (24.2) 30 (26.8) 43 (27.2) 55 (22.8) 72 (26.4) 20 (21.7)

Q2 84 (25.1) 18 (23.7) 79 (25.7) 20 (21.7) 82 (26.4) 17 (19.5) 73 (23.7) 29 (28.4) 79 (27.0) 22 (19.6) 38 (24.1) 62 (25.7) 70 (25.6) 23 (25.0)

Q3 87 (26.0) 16 (21.1) 77 (25.1) 24 (26.1) 79 (25.4) 22 (25.3) 83 (26.9) 20 (19.6) 81 (27.6) 21 (18.8) 40 (25.3) 62 (25.7) 73 (26.7) 17 (18.5)

Q4 78 (23.4) 24 (31.6) 71 (23.1) 28 (30.4) 75 (24.1) 25 (28.7) 77 (25.0) 25 (24.5) 62 (21.2) 39 (34.8) 37 (23.4) 62 (25.7) 58 (21.2) 32 (34.8)

BP14E

Q1 81 (24.3) 22 (28.9) 79 (25.7) 22 (23.9) 76 (24.4) 23 (26.4) 74 (24.0) 29 (28.4) 69 (23.5) 32 (28.6) 35 (22.2) 65 (27.0) 66 (24.2) 21 (22.8)

Q2 84 (25.1) 18 (23.7) 81 (26.4) 17 (18.5) 80 (25.7) 19 (21.8) 77 (25.0) 25 (24.5) 74 (25.3) 25 (22.3) 29 (18.4) 70 (29.0) 71 (26.0) 19 (20.7)

Q3 84 (25.1) 19 (25.0) 83 (27.0) 17 (18.5) 85 (27.3) 17 (19.5) 80 (26.0) 23 (22.5) 74 (25.3) 29 (25.9) 53 (33.5) 49 (20.3) 68 (24.9) 30 (32.6)

Q4 85 (25.4) 17 (22.4) 64 (20.8) 36 (39.1) 70 (22.5) 28 (32.2) 77 (25.0) 25 (24.5) 76 (25.9) 26 (23.2) 41 (25.9) 57 (23.7) 68 (24.9) 22 (23.9)

DNER

Q1 81 (24.3) 22 (28.9) 73 (23.8) 25 (27.2) 77 (24.8) 23 (26.4) 69 (22.4) 34 (33.3) 76 (25.9) 27 (24.1) 33 (20.9) 67 (27.8) 72 (26.4) 20 (21.7)

Q2 85 (25.4) 17 (22.4) 69 (22.5) 32 (34.8) 74 (23.8) 24 (27.6) 74 (24.0) 28 (27.5) 76 (25.9) 25 (22.3) 40 (25.3) 58 (24.1) 67 (24.5) 18 (19.6)

Q3 89 (26.6) 14 (18.4) 79 (25.7) 21 (22.8) 79 (25.4) 19 (21.8) 80 (26.0) 23 (22.5) 73 (24.9) 26 (23.2) 48 (30.4) 51 (21.2) 68 (24.9) 24 (26.1)

Q4 79 (23.7) 23 (30.3) 86 (28.0) 14 (15.2) 81 (26.0) 21 (24.1) 85 (27.6) 17 (16.7) 68 (23.2) 34 (30.4) 37 (23.4) 65 (27.0) 66 (24.2) 30 (32.6)

CD40

Q1 88 (26.3) 15 (19.7) 79 (25.7) 21 (22.8) 79 (25.4) 20 (23.0) 81 (26.3) 22 (21.6) 80 (27.3) 22 (19.6) 43 (27.2) 57 (23.7) 71 (26.0) 20 (21.7)

Q2 81 (24.3) 21 (27.6) 81 (26.4) 19 (20.7) 86 (27.7) 15 (17.2) 78 (25.3) 24 (23.5) 63 (21.5) 38 (33.9) 42 (26.6) 59 (24.5) 73 (26.7) 20 (21.7)

Q3 83 (24.9) 20 (26.3) 68 (22.1) 32 (34.8) 76 (24.4) 22 (25.3) 73 (23.7) 30 (29.4) 74 (25.3) 28 (25.0) 36 (22.8) 63 (26.1) 72 (26.4) 21 (22.8)

Q4 82 (24.6) 20 (26.3) 79 (25.7) 20 (21.7) 70 (22.5) 30 (34.5) 76 (24.7) 26 (25.5) 76 (25.9) 24 (21.4) 37 (23.4) 62 (25.7) 57 (20.9) 31 (33.7)

FGF19

Q1 84 (25.1) 19 (25.0) 78 (25.4) 23 (25.0) 81 (26.0) 16 (18.4) 73 (23.7) 30 (29.4) 62 (21.2) 41 (36.6) 42 (26.6) 56 (23.2) 67 (24.5) 23 (25.0)

Q2 81 (24.3) 21 (27.6) 73 (23.8) 25 (27.2) 78 (25.1) 23 (26.4) 79 (25.6) 23 (22.5) 77 (26.3) 25 (22.3) 47 (29.7) 54 (22.4) 63 (23.1) 30 (32.6)

Q3 84 (25.1) 19 (25.0) 82 (26.7) 17 (18.5) 75 (24.1) 23 (26.4) 78 (25.3) 25 (24.5) 80 (27.3) 21 (18.8) 25 (15.8) 73 (30.3) 68 (24.9) 25 (27.2)

Q4 85 (25.4) 17 (22.4) 74 (24.1) 27 (29.3) 77 (24.8) 25 (28.7) 78 (25.3) 24 (23.5) 74 (25.3) 25 (22.3) 44 (27.8) 58 (24.1) 75 (27.5) 14 (15.2)

CASP8

Q1 89 (26.6) 14 (18.4) 74 (24.1) 26 (28.3) 81 (26.0) 15 (17.2) 76 (24.7) 27 (26.5) 81 (27.6) 21 (18.8) 48 (30.4) 49 (20.3) 72 (26.4) 15 (16.3)

Q2 82 (24.6) 20 (26.3) 79 (25.7) 22 (23.9) 86 (27.7) 14 (16.1) 79 (25.6) 23 (22.5) 65 (22.2) 35 (31.2) 34 (21.5) 67 (27.8) 66 (24.2) 26 (28.3)

Q3 80 (24.0) 23 (30.3) 75 (24.4) 25 (27.2) 74 (23.8) 26 (29.9) 76 (24.7) 27 (26.5) 69 (23.5) 34 (30.4) 44 (27.8) 56 (23.2) 66 (24.2) 25 (27.2)

Q4 83 (24.9) 19 (25.0) 79 (25.7) 19 (20.7) 70 (22.5) 32 (36.8) 77 (25.0) 25 (24.5) 78 (26.6) 22 (19.6) 32 (20.3) 69 (28.6) 69 (25.3) 26 (28.3)

CCL25

Q1 85 (25.4) 18 (23.7) 80 (26.1) 21 (22.8) 70 (22.5) 28 (32.2) 79 (25.6) 24 (23.5) 73 (24.9) 30 (26.8) 42 (26.6) 56 (23.2) 72 (26.4) 14 (15.2)

Q2 80 (24.0) 22 (28.9) 79 (25.7) 23 (25.0) 78 (25.1) 20 (23.0) 75 (24.4) 27 (26.5) 73 (24.9) 26 (23.2) 37 (23.4) 62 (25.7) 67 (24.5) 26 (28.3)

Q3 84 (25.1) 19 (25.0) 75 (24.4) 23 (25.0) 83 (26.7) 18 (20.7) 76 (24.7) 27 (26.5) 73 (24.9) 30 (26.8) 34 (21.5) 67 (27.8) 70 (25.6) 24 (26.1)

Q4 85 (25.4) 17 (22.4) 73 (23.8) 25 (27.2) 80 (25.7) 21 (24.1) 78 (25.3) 24 (23.5) 74 (25.3) 26 (23.2) 45 (28.5) 56 (23.2) 64 (23.4) 28 (30.4)

TNFRSF9

Q1 90 (26.9) 13 (17.1) 83 (27.0) 16 (17.4) 84 (27.0) 17 (19.5) 88 (28.6) 15 (14.7) 76 (25.9) 25 (22.3) 43 (27.2) 59 (24.5) 67 (24.5) 25 (27.2)

Q2 83 (24.9) 19 (25.0) 72 (23.5) 28 (30.4) 80 (25.7) 18 (20.7) 79 (25.6) 23 (22.5) 72 (24.6) 30 (26.8) 34 (21.5) 64 (26.6) 68 (24.9) 21 (22.8)

Q3 87 (26.0) 16 (21.1) 80 (26.1) 22 (23.9) 77 (24.8) 21 (24.1) 76 (24.7) 27 (26.5) 80 (27.3) 22 (19.6) 45 (28.5) 53 (22.0) 68 (24.9) 22 (23.9)

Q4 74 (22.2) 28 (36.8) 72 (23.5) 26 (28.3) 70 (22.5) 31 (35.6) 65 (21.1) 37 (36.3) 65 (22.2) 35 (31.2) 36 (22.8) 65 (27.0) 70 (25.6) 24 (26.1)

TWEAK

Q1 83 (24.9) 20 (26.3) 78 (25.4) 19 (20.7) 80 (25.7) 18 (20.7) 73 (23.7) 30 (29.4) 67 (22.9) 34 (30.4) 39 (24.7) 60 (24.9) 70 (25.6) 22 (23.9)

Q2 80 (24.0) 22 (28.9) 81 (26.4) 19 (20.7) 73 (23.5) 26 (29.9) 82 (26.6) 20 (19.6) 74 (25.3) 27 (24.1) 32 (20.3) 67 (27.8) 62 (22.7) 29 (31.5)

Q3 85 (25.4) 18 (23.7) 74 (24.1) 29 (31.5) 71 (22.8) 28 (32.2) 74 (24.0) 29 (28.4) 77 (26.3) 26 (23.2) 43 (27.2) 56 (23.2) 68 (24.9) 24 (26.1)

Q4 86 (25.7) 16 (21.1) 74 (24.1) 25 (27.2) 87 (28.0) 15 (17.2) 79 (25.6) 23 (22.5) 75 (25.6) 25 (22.3) 44 (27.8) 58 (24.1) 73 (26.7) 17 (18.5)

ST1A1

Q1 103 (30.8) 18 (23.7) 95 (30.9) 22 (23.9) 100 (32.2) 15 (17.2) 90 (29.2) 31 (30.4) 80 (27.3) 38 (33.9) 41 (25.9) 75 (31.1) 78 (28.6) 28 (30.4)

Q2 61 (18.3) 23 (30.3) 63 (20.5) 20 (21.7) 63 (20.3) 19 (21.8) 62 (20.1) 22 (21.6) 55 (18.8) 29 (25.9) 34 (21.5) 48 (19.9) 58 (21.2) 20 (21.7)

Q3 85 (25.4) 18 (23.7) 74 (24.1) 27 (29.3) 76 (24.4) 27 (31.0) 81 (26.3) 22 (21.6) 78 (26.6) 25 (22.3) 47 (29.7) 56 (23.2) 71 (26.0) 21 (22.8)

Q4 85 (25.4) 17 (22.4) 75 (24.4) 23 (25.0) 72 (23.2) 26 (29.9) 75 (24.4) 27 (26.5) 80 (27.3) 20 (17.9) 36 (22.8) 62 (25.7) 66 (24.2) 23 (25.0)

STAMPB

Q1 84 (25.1) 19 (25.0) 78 (25.4) 22 (23.9) 87 (28.0) 12 (13.8) 79 (25.6) 24 (23.5) 70 (23.9) 32 (28.6) 37 (23.4) 63 (26.1) 68 (24.9) 23 (25.0)

Q2 80 (24.0) 22 (28.9) 79 (25.7) 21 (22.8) 73 (23.5) 25 (28.7) 72 (23.4) 30 (29.4) 68 (23.2) 32 (28.6) 40 (25.3) 58 (24.1) 72 (26.4) 18 (19.6)

Q3 84 (25.1) 19 (25.0) 73 (23.8) 25 (27.2) 80 (25.7) 22 (25.3) 79 (25.6) 24 (23.5) 76 (25.9) 27 (24.1) 42 (26.6) 60 (24.9) 63 (23.1) 28 (30.4)

Q4 86 (25.7) 16 (21.1) 77 (25.1) 24 (26.1) 71 (22.8) 28 (32.2) 78 (25.3) 24 (23.5) 79 (27.0) 21 (18.8) 39 (24.7) 60 (24.9) 70 (25.6) 23 (25.0)

ADA

Q1 86 (25.7) 17 (22.4) 74 (24.1) 25 (27.2) 82 (26.4) 18 (20.7) 73 (23.7) 30 (29.4) 80 (27.3) 21 (18.8) 43 (27.2) 59 (24.5) 79 (28.9) 14 (15.2)

Q2 82 (24.6) 20 (26.3) 76 (24.8) 25 (27.2) 76 (24.4) 19 (21.8) 79 (25.6) 23 (22.5) 76 (25.9) 26 (23.2) 40 (25.3) 55 (22.8) 64 (23.4) 23 (25.0)

Q3 84 (25.1) 19 (25.0) 75 (24.4) 25 (27.2) 74 (23.8) 28 (32.2) 79 (25.6) 24 (23.5) 66 (22.5) 36 (32.1) 33 (20.9) 69 (28.6) 74 (27.1) 18 (19.6)

Q4 82 (24.6) 20 (26.3) 82 (26.7) 17 (18.5) 79 (25.4) 22 (25.3) 77 (25.0) 25 (24.5) 71 (24.2) 29 (25.9) 42 (26.6) 58 (24.1) 56 (20.5) 37 (40.2)

TNFB

Q1 86 (25.7) 17 (22.4) 80 (26.1) 18 (19.6) 89 (28.6) 12 (13.8) 89 (28.9) 14 (13.7) 70 (23.9) 30 (26.8) 35 (22.2) 67 (27.8) 67 (24.5) 24 (26.1)

Q2 94 (28.1) 8 (10.5) 82 (26.7) 19 (20.7) 76 (24.4) 19 (21.8) 81 (26.3) 21 (20.6) 79 (27.0) 23 (20.5) 35 (22.2) 61 (25.3) 70 (25.6) 20 (21.7)

Q3 77 (23.1) 26 (34.2) 74 (24.1) 27 (29.3) 73 (23.5) 29 (33.3) 73 (23.7) 30 (29.4) 72 (24.6) 29 (25.9) 35 (22.2) 67 (27.8) 71 (26.0) 22 (23.9)

Q4 77 (23.1) 25 (32.9) 71 (23.1) 28 (30.4) 73 (23.5) 27 (31.0) 65 (21.1) 37 (36.3) 72 (24.6) 30 (26.8) 53 (33.5) 46 (19.1) 65 (23.8) 26 (28.3)

CSF1

Q1 86 (25.7) 17 (22.4) 81 (26.4) 18 (19.6) 82 (26.4) 18 (20.7) 84 (27.3) 19 (18.6) 77 (26.3) 25 (22.3) 46 (29.1) 55 (22.8) 69 (25.3) 21 (22.8)

Q2 82 (24.6) 20 (26.3) 75 (24.4) 23 (25.0) 74 (23.8) 26 (29.9) 78 (25.3) 24 (23.5) 70 (23.9) 31 (27.7) 38 (24.1) 61 (25.3) 68 (24.9) 27 (29.3)

Q3 86 (25.7) 17 (22.4) 77 (25.1) 25 (27.2) 76 (24.4) 23 (26.4) 75 (24.4) 28 (27.5) 78 (26.6) 24 (21.4) 38 (24.1) 62 (25.7) 73 (26.7) 19 (20.7)

Q4 80 (24.0) 22 (28.9) 74 (24.1) 26 (28.3) 79 (25.4) 20 (23.0) 71 (23.1) 31 (30.4) 68 (23.2) 32 (28.6) 36 (22.8) 63 (26.1) 63 (23.1) 25 (27.2)

ENRAGE

Q1 88 (26.3) 15 (19.7) 80 (26.1) 21 (22.8) 83 (26.7) 17 (19.5) 80 (26.0) 23 (22.5) 79 (27.0) 22 (19.6) 47 (29.7) 54 (22.4) 77 (28.2) 20 (21.7)

Q2 82 (24.6) 20 (26.3) 77 (25.1) 22 (23.9) 80 (25.7) 21 (24.1) 78 (25.3) 24 (23.5) 66 (22.5) 35 (31.2) 34 (21.5) 67 (27.8) 69 (25.3) 20 (21.7)

Q3 80 (24.0) 23 (30.3) 72 (23.5) 28 (30.4) 79 (25.4) 18 (20.7) 78 (25.3) 25 (24.5) 72 (24.6) 30 (26.8) 35 (22.2) 63 (26.1) 53 (19.4) 36 (39.1)

Q4 84 (25.1) 18 (23.7) 78 (25.4) 21 (22.8) 69 (22.2) 31 (35.6) 72 (23.4) 30 (29.4) 76 (25.9) 25 (22.3) 42 (26.6) 57 (23.7) 74 (27.1) 16 (17.4)

MCP3

Q1 87 (26.0) 16 (21.1) 74 (24.1) 25 (27.2) 79 (25.4) 23 (26.4) 79 (25.6) 24 (23.5) 86 (29.4) 15 (13.4) 43 (27.2) 59 (24.5) 74 (27.1) 17 (18.5)

Q2 82 (24.6) 20 (26.3) 82 (26.7) 19 (20.7) 78 (25.1) 19 (21.8) 77 (25.0) 25 (24.5) 70 (23.9) 32 (28.6) 35 (22.2) 63 (26.1) 72 (26.4) 21 (22.8)

Q3 88 (26.3) 15 (19.7) 73 (23.8) 27 (29.3) 74 (23.8) 24 (27.6) 79 (25.6) 24 (23.5) 78 (26.6) 24 (21.4) 43 (27.2) 54 (22.4) 68 (24.9) 19 (20.7)

Q4 77 (23.1) 25 (32.9) 78 (25.4) 21 (22.8) 80 (25.7) 21 (24.1) 73 (23.7) 29 (28.4) 59 (20.1) 41 (36.6) 37 (23.4) 65 (27.0) 59 (21.6) 35 (38.0)

OSM

Q1 83 (24.9) 20 (26.3) 74 (24.1) 28 (30.4) 75 (24.1) 26 (29.9) 81 (26.3) 22 (21.6) 76 (25.9) 26 (23.2) 45 (28.5) 56 (23.2) 74 (27.1) 24 (26.1)

Q2 77 (23.1) 25 (32.9) 72 (23.5) 26 (28.3) 77 (24.8) 21 (24.1) 70 (22.7) 32 (31.4) 71 (24.2) 29 (25.9) 33 (20.9) 66 (27.4) 62 (22.7) 27 (29.3)

Q3 86 (25.7) 17 (22.4) 77 (25.1) 21 (22.8) 86 (27.7) 14 (16.1) 84 (27.3) 19 (18.6) 73 (24.9) 29 (25.9) 35 (22.2) 65 (27.0) 67 (24.5) 20 (21.7)

Q4 88 (26.3) 14 (18.4) 84 (27.4) 17 (18.5) 73 (23.5) 26 (29.9) 73 (23.7) 29 (28.4) 73 (24.9) 28 (25.0) 45 (28.5) 54 (22.4) 70 (25.6) 21 (22.8)

CCL28

Q1 95 (28.4) 34 (44.7) 100 (32.6) 25 (27.2) 95 (30.5) 28 (32.2) 88 (28.6) 41 (40.2) 76 (25.9) 51 (45.5) 48 (30.4) 74 (30.7) 79 (28.9) 35 (38.0)

Q2 61 (18.3) 15 (19.7) 53 (17.3) 22 (23.9) 57 (18.3) 17 (19.5) 58 (18.8) 18 (17.6) 54 (18.4) 20 (17.9) 21 (13.3) 54 (22.4) 55 (20.1) 14 (15.2)

Q3 85 (25.4) 18 (23.7) 77 (25.1) 22 (23.9) 76 (24.4) 25 (28.7) 78 (25.3) 25 (24.5) 78 (26.6) 25 (22.3) 44 (27.8) 58 (24.1) 67 (24.5) 23 (25.0)

Q4 93 (27.8) 9 (11.8) 77 (25.1) 23 (25.0) 83 (26.7) 17 (19.5) 84 (27.3) 18 (17.6) 85 (29.0) 16 (14.3) 45 (28.5) 55 (22.8) 72 (26.4) 20 (21.7)

SLAMF1

Q1 88 (26.3) 15 (19.7) 79 (25.7) 22 (23.9) 84 (27.0) 17 (19.5) 84 (27.3) 19 (18.6) 72 (24.6) 28 (25.0) 35 (22.2) 66 (27.4) 71 (26.0) 24 (26.1)

Q2 87 (26.0) 15 (19.7) 80 (26.1) 20 (21.7) 79 (25.4) 18 (20.7) 77 (25.0) 25 (24.5) 72 (24.6) 29 (25.9) 47 (29.7) 52 (21.6) 70 (25.6) 23 (25.0)

Q3 79 (23.7) 24 (31.6) 70 (22.8) 31 (33.7) 72 (23.2) 29 (33.3) 75 (24.4) 28 (27.5) 73 (24.9) 29 (25.9) 39 (24.7) 62 (25.7) 63 (23.1) 22 (23.9)

Q4 80 (24.0) 22 (28.9) 78 (25.4) 19 (20.7) 76 (24.4) 23 (26.4) 72 (23.4) 30 (29.4) 76 (25.9) 26 (23.2) 37 (23.4) 61 (25.3) 69 (25.3) 23 (25.0)

IL17C

Q1 297 (88.9) 64 (84.2) 269 (87.6) 82 (89.1) 275 (88.4) 75 (86.2) 274 (89.0) 87 (85.3) 251 (85.7) 105 (93.8) 146 (92.4) 205 (85.1) 237 (86.8) 83 (90.2)

Q2 37 (11.1) 12 (15.8) 38 (12.4) 10 (10.9) 36 (11.6) 12 (13.8) 34 (11.0) 15 (14.7) 42 (14.3) 7 ( 6.2) 12 ( 7.6) 36 (14.9) 36 (13.2) 9 ( 9.8)

AXIN1

Q1 194 (58.1) 43 (56.6) 181 (59.0) 50 (54.3) 188 (60.5) 41 (47.1) 178 (57.8) 59 (57.8) 162 (55.3) 72 (64.3) 91 (57.6) 139 (57.7) 157 (57.5) 52 (56.5)

Q2 66 (19.8) 21 (27.6) 65 (21.2) 18 (19.6) 66 (21.2) 20 (23.0) 64 (20.8) 23 (22.5) 60 (20.5) 27 (24.1) 31 (19.6) 55 (22.8) 60 (22.0) 18 (19.6)

Q3 74 (22.2) 12 (15.8) 61 (19.9) 24 (26.1) 57 (18.3) 26 (29.9) 66 (21.4) 20 (19.6) 71 (24.2) 13 (11.6) 36 (22.8) 47 (19.5) 56 (20.5) 22 (23.9)

SIRT2

Q1 209 (62.6) 51 (67.1) 195 (63.5) 57 (62.0) 201 (64.6) 50 (57.5) 198 (64.3) 62 (60.8) 177 (60.4) 80 (71.4) 100 (63.3) 152 (63.1) 171 (62.6) 57 (62.0)

Q2 63 (18.9) 12 (15.8) 57 (18.6) 15 (16.3) 60 (19.3) 13 (14.9) 54 (17.5) 21 (20.6) 62 (21.2) 13 (11.6) 27 (17.1) 47 (19.5) 53 (19.4) 16 (17.4)

Q3 62 (18.6) 13 (17.1) 55 (17.9) 20 (21.7) 50 (16.1) 24 (27.6) 56 (18.2) 19 (18.6) 54 (18.4) 19 (17.0) 31 (19.6) 42 (17.4) 49 (17.9) 19 (20.7)

IL10RA

Q1 224 (67.1) 55 (72.4) 210 (68.4) 64 (69.6) 211 (67.8) 60 (69.0) 207 (67.2) 72 (70.6) 200 (68.3) 75 (67.0) 99 (62.7) 172 (71.4) 191 (70.0) 61 (66.3)

Q2 55 (16.5) 11 (14.5) 45 (14.7) 16 (17.4) 51 (16.4) 13 (14.9) 49 (15.9) 17 (16.7) 47 (16.0) 18 (16.1) 32 (20.3) 32 (13.3) 39 (14.3) 16 (17.4)

Q3 55 (16.5) 10 (13.2) 52 (16.9) 12 (13.0) 49 (15.8) 14 (16.1) 52 (16.9) 13 (12.7) 46 (15.7) 19 (17.0) 27 (17.1) 37 (15.4) 43 (15.8) 15 (16.3)

NT3

Q1 208 (62.3) 42 (55.3) 185 (60.3) 57 (62.0) 203 (65.3) 39 (44.8) 189 (61.4) 61 (59.8) 181 (61.8) 65 (58.0) 96 (60.8) 146 (60.6) 165 (60.4) 62 (67.4)

Q2 63 (18.9) 17 (22.4) 64 (20.8) 14 (15.2) 55 (17.7) 24 (27.6) 62 (20.1) 18 (17.6) 56 (19.1) 23 (20.5) 32 (20.3) 48 (19.9) 54 (19.8) 16 (17.4)

Q3 63 (18.9) 17 (22.4) 58 (18.9) 21 (22.8) 53 (17.0) 24 (27.6) 57 (18.5) 23 (22.5) 56 (19.1) 24 (21.4) 30 (19.0) 47 (19.5) 54 (19.8) 14 (15.2)

All Values presented as N(%)

Figure S1. Heatmap of Pearson’s correlation coefficients for log transformed marker levels among markers associated with AHA/NHLBI metabolic syndrome

(left) or low physical activity (right). Markers are ordered according to similarity as determined by hierarchical clustering.

Asterisks denote level of statistical significance: * P < 0.05, ** P < 0.01, *** P < 0.001.

Documents

Table S1. Complete list of markers and quantile ......SAP Serum amyloid P 100.0 ≤44444000 44502000-56756000 56762000-71779000 ≥71809000 pg/mL SCF Stem cell factor 90.5 ≤16.6