OCTOBER 2019 | REPORT

SUPPORT THE MICROBIOTA WITHFUNCTIONAL FOOD AND DRINK

From prebiotics to probiotics to postbiotics, a range of ingredients andmicroorganisms are emerging in food and drink products to support themicrobiota.

Stephanie Mattucci,Associate Director, GlobalFood Science

1 © 2019 Mintel Group Ltd. All Rights Reserved. Confidential to Mintel.

Table of ContentsUTILIZE PROBIOTICS AND PREBIOTICS............................................................................................ 4

[Graph] Global: percentage of food and drink launches with claims related to digestive health, Sep

2014-Aug 2019.................................................................................................................................. 5

[Graph] Europe: % of consumers taking functional food and drink to maintain/improve digestive

health, 2015 vs 2018......................................................................................................................... 6

TAP INTO THE GROWING POSTBIOTICS TREND ........................................................................... 12

EXPLORE OPPORTUNITIES BEYOND GUT HEALTH ......................................................................17

[Graph] US: reasons for taking probiotics, April 2018 .....................................................................18

[Graph] China: perception of probiotics, November 2017 ...............................................................18

[Graph] Global: percentage of probiotic food and drink launches with select functional claims, Sep

2014-Aug 2019................................................................................................................................ 19

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Mintel recommendsUtilize probiotics and prebioticsOffer consumers ways to support the gut microbiota through functional products with probiotics orprebiotics. Natural sources of probiotics, such as lactofermented foods and other fermented products,will also resonate.

Tap into the growing postbiotics trendLook to postbiotics for new ways to provide the benefits of probiotics without the technical challenges.Recent patent filings, social media mentions and niche product launches indicate this is the nextmicrobiome-related trend to watch.

Explore opportunities beyond gut healthImmunity is an untapped opportunity for probiotic food and drink products. Looking forward, the gut-brainaxis is another exciting research area that holds promise for future pre-, pro- and postbiotic products toprovide brain and cognitive support.

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UTILIZE PROBIOTICS AND PREBIOTICS

Use probiotics and prebiotics to support a healthy gut microbiota, which is thepopulation of microorganisms that live in the gut. The gut microbiota has beenassociated with many areas of human health. Beyond digestive health, the gutmicrobiota may influence immune health, metabolic health and evenneurobehavioral traits. Look beyond probiotic fortification to develop products thatsupport the microbiota, including lactofermented foods and prebiotics that nourishthe good bacteria in the gut.

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Pair pre- and probiotic claims with more familiar ones, such asfiber or digestive healthProbiotic and prebiotic claims still lag behind more familiar claims related to fiber or digestive health (egsupports regularity, aid in digestion, rebalances GI flora).

% o

f la

unch

es

Global: percentage of food and drink launches with claims related to digestive health,Sep 2014-Aug 2019

High/added fiber Functional – digestive Probiotic Prebiotic

Sep 2014-Aug2015

Sep 2015-Aug2016

Sep 2016-Aug2017

Sep 2017-Aug2018

Sep 2018-Aug2019

0%

1%

2%

3%

Source: Mintel GNPD

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Interest in digestive health is increasing, and with it, the potentialfor products that offer microbiota supportDigestive health is a growing key health priority for consumers. In the UK, 66% of consumers agree thatactively looking after your gut health is essential to overall wellness.

Greater understanding and awareness of the importance of gut health for overall wellbeing provides fertileground for innovation around functional, gut-friendly food and beverages. In the US, 29% of Millennialbeverage consumers are interested in drinks with probiotics.

% c

onsu

mer

s

Europe: % of consumers taking functional food and drink tomaintain/improve digestive health, 2015 vs 2018

2828

4444

2929

4343 41413434

5454

39394545 4545

2015 2018

France Germany Italy Spain Poland

0

25

50

75

Base: internet users aged 16+ who have used functional food and drink in the last six months (2015 –France: 788; Germany: 714; Italy: 895; Spain: 853; Poland: 949) (2018 – France: 1,045; Germany: 1,003;Italy: 1,212; Spain: 1,431; Poland: 1,458)Source: Lightspeed/Mintel (2015; 2018)

Mintel analysts call out category-blurring gut healthopportunties

Innovation in gut health products is blurring the lines between categories and creating new opportunitiesfor functional food and beverages.

Shifting from "beer belly" to better-for-you

Beyond Kombucha Mava Roka Kombucha Ale makes a kombucha withapproximately 6% ABV (US).Jonny Forsyth looks at how hard kombucha has potential to attracthealth-focused consumers.

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Key learnings from growing interest in water kefir

Strawberry & Basil Water Kefir. Vegan water kefir is made by combiningkefir grains with juice or sugar water (Australia).Ophélie Buchet explores how water kefirs can offer consumersauthentic, vegan probiotics in new flavors and formats.

Hummus should be a "health hero"

Cashew Hummus & Classic Crackers Snack Pack features liveprobiotic cultures for better health and nutrition (US).Edward Bergen suggests hummus brands can use pre- and probiotics,either in the formulation itself or as part of a topping.

Source: Instagram (#mavaroka)

Brands begin discussing the microbiota on packAlthough on-pack mentions of the microbiome or microbiota are incredibly niche, these types of references

have potential to grow as this exciting area of research expands.

Establishing a healthy microbiome early on

Nestlé NAN Optipro Stage 4 Baby Formula contains HM-0, said toestablish healthy microbiota, strengthening the immune system. Alsocontains L. confortis, a breast milk isolate probiotic that helps reducecommon digestive problems (Mexico).

Nurturing the microbiome with living probiotics

GT's VeggieKefir Kimchi Living Probiotic Shots is fermented with vegankefir cultures and said to deliver a powerful shot of living probiotics thatis claimed to support gut health and nurture the microbiome (US).

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Fiber to feed the good bacteria

Special K Cereal with Forest Berries contains fiber from grains, whichpromotes the growth of Bifidobacteria and Lactobacillus, supporting apositive change in the intestinal microbiota and better digestive balance(Australia).

Prioritize prebiotics in conversations about the microbiotaPrebiotics are types of fiber that stimulate the growth of gut bacteria. While all prebiotics are fibers, not allfibers are prebiotic. Recently, the term microbiota-accessible carbohydrates (MAC) has emerged as amore precise way to talk about these beneficial carbohydrates.

In a diet devoid of prebiotic fibers, research suggests some gut microbes may turn to the only otheravailable food source: the mucus lining that protects the gut. This can lead to negative healthconsequences, including the possibility of autoimmune and inflammatory diseases.

Capitalize on consumers' growing interest in gut health to engage them with prebiotics and fibers. Educateconsumers about the benefits of fiber, as well as prebiotics and the microbiota. Consider prebiotics as partof a solution for holistic health.

Continued research about the microbiota is discovering that these unique ecosystems of microorganismsplay significant roles in our overall health and wellness. As probiotics gain more momentum andrecognition, focus on the role certain fibers also have in keeping gut microbes healthy and well-fed.

Incorporate prebiotics into products for digestive healthMany functional fibers offer prebiotic benefits. Capitalize on consumers' growing interest in gut health to

engage them with prebiotics and fiber.

Promotes multiple benefits of prebiotics

Prebiotics FOS 3500 Supplement contains 3,500mg offructooligosaccharide, which is said to help increase Lactobacillus,suppress harmful bacteria, aid in intestinal regularity and help in theabsorption of calcium (South Korea).

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Natural source of prebiotics

Green Banana Flour. Made from 100% green banana flour, this vegan-and paleo-friendly flour is gluten-free and features resistant starch thatworks as a prebiotic (Venezuela).

Double benefit from probiotics and prebiotics

Grapefruit Flavored Drinking Bio Yoghurt features a double benefit: ithas two times more live bacterial cultures to improve microflora and hasfiber to improve digestion. It is enriched with Bifidobacterium andprebiotic inulin (Russia).

Fibers benefit digestive health and microbiota diversity

START THE DAY WITHFIBER

42%

of UK consumers whotypically eat breakfast

cereal look for high-fiberclaims when choosing

breakfast cereal

PROMOTEPREBIOTICS ALONGWITH PROBIOTICS

42%

of yogurt consumers inBrazil would like to knowmore about the benefits

of yogurts with probiotics/prebiotics

HELP CONSUMERSEAT MORE FIBER

54%

of urban Indians aretrying to eat more fiber in

their diets

Base: 1,762 UK internet users aged 16+ who typically eat breakfast cereal; 1,346 Brazilian internetusers aged 16+ who have eaten yogurt in the last three months; 3,000 urban Indian internet usersaged 18+Source: Lightspeed/Mintel; Ipsos Observer/Mintel

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Repurpose spent grains as a source of prebiotic fibers

Canvas promotes prebioticfiber in smoothies

Regrained has added"prebiotic upcycled

supergrains" to its packaging

Explore new possibilities forprebiotic-rich fibers found inspent grains.

US-based brand Regrainedwas one of the earliestpackaged foods usingrepurposed brewery grains tofight food waste. The brand isnow positioning spent grainsas "prebiotic upcycledsupergrains."

Canvas Fiber + ProteinShakes in the US also claimto help reduce food waste byusing fiber- and protein-richspent grain isolate to deliverprebiotic benefits for gut anddigestive health.

New encapsulation technology will help protect vulnerable pre-and probioticsInternational Flavors & Fragrances Inc.PCT publication WO2017/161364A1 describes a method of preparation of a highly stable microcapsule sothat it coats and effectively protects active ingredients, like probiotics and prebiotics, from the extremegastrointestinal (GI) tract environment.

The microcapsule wall consists of two polymer layers. The first polymer is a sol-gel polymer. The secondpolymer is formed of gum arabic, purity gum ultra, gelatin, chitosan, xanthan gum, plant gum,carboxymethyl cellulose and sodium carboxymethyl guar gum.

Lord NovarexThis company has a granted Korean patent, KR101562048B1, disclosing the method of coating garlicpowder with hydroxypropyl methylcellulose phthalate (HPMCP) to prevent the degradation of garlic's activeingredient in the stomach.

This helps maximize garlic's intestinal absorption, thereby providing benefits like nutrition and invigoration,vitamin retention effect and gastrointestinal improvement.

Source: Cipher

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Lacto-Fermented Cabbage& Carrots is described as a

natural probiotic

What's next? Call out lactofermentationThe fermentation movement has been emerging for several years andhas potential to continue to expand as consumers seek natural ways tosupport their microbiota.

Food and drink manufacturers can draw inspiration from culinary iconsand promote naturally fermented products. For example, renowned chefRene Redzepi highlighted different fermentation techniques – includinglactofermentation – in his 2018 book The Noma Guide to Fermentation.

Lactofermentation is so ubiquitous that it is rarely mentioned on pack.Lactic acid bacteria is responsible for many familiar fermented foodssuch as kimchi, sauerkraut, yogurt and sourdough. In lactofermentation,lactic acid bacteria converts sugars into lactic acid. Not only does lacticacid provide a tangy, sour flavor to fermented foods, but it also acts as anatural preservative.

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TAP INTO THE GROWING POSTBIOTICSTREND

Postbiotic is a newly coined term for non-viable (dead) bacteria and their beneficialmetabolites in the form of peptidoglycans, polysaccharides, short-chain fatty acidsand other organic acids. These beneficial compounds produced by bacteria in thedigestive tract could be key regulators of gastrointestinal health and help decreaseinflammation and boost immunity. Postbiotics are sometimes referred to asinactivated probiotics, paraprobiotics, heat-killed bacteria or heat-inactivatedbacteria.

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Cookies with bioAXTivepostbiotic lactobacillus

Use postbiotics to provide probiotic benefitsin new categoriesKeeping probiotics viable can be difficult in certain categories becauseheat treatment, ambient storage and low water activity can be detrimentalto live probiotics. However, postbiotics can offer the benefits of probioticswithout the technical challenges.

Bronnen Asia's BioAXTive's postbiotic promises the benefits of probioticswithout the product development challenges. Their postbiotic is heatstable, pressure stable and shelf stable. Additionally, it is easy to blend infood and beverage products and does not ferment finished productsbecause it does not contain live or active cultures. Instead, the ingredientis composed of secondary metabolites produced by Lactobacillus sp.,also known as Lactobacillus fermented extract.

Interest in postbiotic heightens on social mediaAs consumers are gainingawareness and interest in thebenefits of postbiotics, brandsshould move beyond probioticsand prebiotics for gut andimmune health.

Mentions of postbiotics on USsocial media sites have seen a91% monthly increase over thelast year. Brands shouldeducate consumers about thislatest gut microbiome ingredienttrend and look for ways toincorporate postbiotics intofunctional foods.

* social media mentions of probiotics, prebiotics and postbiotics on Instagram, Pinterest and Twitter, July2018-July 2019Source: Infegy/Mintel

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With postbiotics to gentlycleanse the skin and

support the microbiome

Postbiotics have cross-category appealPostbiotics are also emerging outside the food and drink category, whichcan provide further inspiration for food and drink. Recent beautylaunches are also incorporating postbiotics, known as the beneficialextracts that living bacteria give off when put though a fermentationprocess. Non-living bacteria, called lysates, and all the useful matter theysecrete, also fall under the postbiotic umbrella.

Patent activity for postbiotics in beauty have included a method forpreparing a kimchi Lactobacillus fermented pine needle extract that canhelp prevent and improve acne (Derma Wrap Co., Ltd.) and probioticPediococcus acidilactici strain fermented grain that exhibits highantibacterial/anti-inflammatory activity against acne (FermentationMicroorganism Industry Promotion Foundation).

Source: Cipher

Although niche, postbiotics are emerging across categories

In dietary supplements

Dr. Ohhira's Fermented Food Supplement contains pro-, pre- andpostbiotics. Postbiotics include nutrients developed in the fermentationprocess, such as short-chain fatty acids, other organic acids,oligosaccharides and polyphenols (US).

In plant-based dairy for digestive support

Hanmi Jeonduyu 5000 Soy Milk with Lactobacillus is made with 100%Korean soybean and contains 500 billion patented heat-killedLactobacillus EF-2001 powder to support the digestive system (SouthKorea).

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In pet food for immune support

Purina One Kitten Food with Chicken and Wholegrains is formulatedwith beneficial functional bacteria that support the cat's natural immunedefenses. Contains dried heat-inactivated Lactobacillus ferment(Russia).

L-137 Lactic Acid PowderSticks

"Dead probiotics" offer health benefitsHeat-killed Lactobacillus plantarum L-137 (HK L-137) comes from abacterial strain isolated from a fermented rice and fish dish. Researchhas found HK L-137 has benefits for the immune system, and may havepotential to prevent or reduce the duration and severity of the commoncold. HK L-137 has antioxidant benefits and may help reduce chronicinflammation associated with metabolic disorders.

HK L-137 has been commercialized by House Wellness Foods of Japanand is positioned as an immunological supplement and as an ingredientused in functional foods. Heat-killed bacteria offer benefits to productdevelopers as the ingredient is suitable for long-term storage and can beeasily incorporated into a range of products. Studies have found heat-treating Lactobacillus plantarum L-137 enhances immunomodulatoryactivity and stability in simulated digestive juices.

Postbiotic is the new trend for gut health in recent patent filingsDuPont Nutrition Biosciences filed a PCT (WO2018050623A1) claiming L. crispatus LMG18199 or itsmetabolite can be used as an active ingredient in food products. These metabolites are resistant to acidand bile fluid and help in preventing and/or treating gastrointestinal disorders.

A US pending publication (US20190099438A1) filed by Nitto Pharmaceutical Industries disclosesexopolysaccharide produced by Leuconostoc mesenteroides to treat metabolic disorders like obesityand diabetes. These metabolites help in decreasing a ratio of Firmicutes bacteria to Bacteroidetes bacteriain the intestine and increasing the amount of short-chain fatty acids in the intestine.

Source: Cipher

RB (Mead Johnson) has a PCT publication (WO2017078907A1) that describes the method of producingLactobacillus rhamnosus GG (LGG) soluble mediators and its use in pediatric nutritional composition.The soluble mediator is used instead of probiotics to improve impaired gut barrier function and to reducevisceral pain in a pediatric subject.

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TCI Co filed a US patent application (US20180264054A1) for Lactobacillus plantarum TCI378 and itsmetabolites. The pending application discloses the use of either the bacteria or its metabolite as anactive ingredient in food, pharmaceuticals or animal feed to improve gastrointestinal functions and toreduce weight by enhancing fat metabolism.

Source: Cipher

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Target immune system health through microbiotal support. Although digestivehealth claims are more common on probiotic food and drink products, manyconsumers recognize the benefits probiotics have for immunity. Looking forward,new research and patents related to the gut-brain axis will create new opportunitiesfor pro-, pre- and postbiotics to support mental and cognitive health.

EXPLORE OPPORTUNITIES BEYOND GUTHEALTH

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Consumers associate probiotics with many different benefitsConsumers want their probiotics to serve multiple needs, from improving gut health to boosting generalwellness.

China: perception of probiotics, November 2017

63%63%

58%58%

46%46%

46%46%

35%35%

30%30%

24%24%

Help absorb nutrients

Boost immunity

Increase appetite

Help bowel movement

Help lose weight

Prevent cardiovascular diseases

Release anxiety

US: reasons for taking probiotics, April 2018

67%67%

49%49%

45%45%

43%43%

32%32%

17%17%

13%13%

For a healthy gut/microbiome

For general wellbeing

To maintain regular bowelmovements

For immune system health

For better nutrient absorption

For better skin

For weight loss

Base: China: 3,000 internet users aged 20-49; US: 301 internet users aged 18+ who use probioticsupplementsSource: KuRunData/Mintel; Lightspeed/Mintel

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Immune health is an untapped opportunity for probioticsDigestive functional claims are more common than immune claims on probiotic food and drink products.Prebiotic products are also more likely to make digestive health claims.

Global: percentage of probiotic food and drink launches with select functional claims,Sep 2014-Aug 2019

34%34%39%39% 39%39% 35%35%

33%33%

17%17%

14%14%16%16% 17%17%

15%15%

Functional – digestive Functional – immune system

Sep 2014-Aug 2015 Sep 2015-Aug 2016 Sep 2016-Aug 2017 Sep 2017-Aug 2018 Sep 2018-Aug 2019

Source: Mintel GNPD

Probiotic products highlight multiple health benefitsTap into the different benefits that probiotics can provide, such as supporting digestive and immune health.

Active probiotics for gut and immunity

North Coast Organic Apple Sauce + Probiotics Pouches claim to helpgut and immune health with probiotic Bacillus coagulans Unique IS-2(US).

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Vitamin C and probiotics for immune support

LALA Orange and Pineapple Flavored Probiotic Smoothie builds on theconnection for immune support by providing 100% of the dailyrecommendation for vitamin C along with 3g of prebiotic fiber andbillions of probiotics BB-12 and LLG (US).

Prebiotics to aid digestive and immune function

Kréol Prebiotic Sparkling Drink Passionfruit & Orange claims tostimulate good bacteria in the gut and is designed for a healthy gut andmind. Contains live probiotic cultures and prebiotic fiber (Australia).

Recent patent filings connect gut health with immunityMorinaga Milk Industry has established manufacturing technology for dairy-derived ingredientsincluding Bifidobacterium longum BB536, which is claimed to support a healthy immune system andprovide a natural defence against digestive problems like constipation and abdominal discomfort.

Yakult Co., which is already active in dairy products for improving gut health, has a granted Koreanpatent, KR101511976B1, for Lactobacillus fermentum HY7301, which produces polysaccharides havingimmune-stimulating activity. The claimed strain is used as an active ingredient in a fermented milkproduct.

Polysaccharide fraction isolated from a byproduct of carrot is disclosed in granted patentKR101915715B1, filed by BK Bio Co. in collaboration with Chungnam National University. Theclaimed fraction has an immune-boosting function and could be used as an active ingredient in food.

Source: Cipher

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OF US VMS USERS

85%

are interested insupplements that

enhance mental health(eg improves memory,

protects againstdepression)

What's next? Tap into the gut-brain axisAs more research becomes available, educate consumers about theconnection between the gut and the brain. Probiotics, prebiotics andpostbiotics tailored to promote brain health will appeal to consumers whoare interested in preventative care and supplements that help supporttheir wellness goals. Psychobiotics, probiotics that affect the brain, mayhave potential to help people struggling with anxiety and depression.

Base: 1,698 US internet users aged 18+ who use vitamins, minerals or supplementsSource: Lightspeed/Mintel

Morinaga sees opportunity to combat mental health challengesTackling mental health issuesMorinaga Milk Industry has a PCT publication (WO2018155565A1) that proposes that mental healthdisorders can be alleviated by daily ingestion of food and drink containing a bacterium belonging to theBifidobacteriumlongum subspecies infantis (B. infantis).

Reducing mental stress with probioticsIn January 2019, Morinaga announced findings from a recent study that found supplementation withMorinaga's Bifidobacterium infantis M-63 helped improve the mental state of flood victims in Malaysia.

Preventing the onset of Alzheimer's diseaseIn March 2018, Morinaga announced the results of a study investigating the preventative effects of itsnew probiotic strain Bifidobacterium breve A1 on a model of Alzheimer's disease. The strain improvedspatial recognition, learning and memory capabilities in mice with cognitive dysfunction similar toAlzheimer's disease.

Source: Cipher; Morinaga Milk

Research is starting to explore the gut-brain axisPrebioticsAccording to the journal Psychopharmacology, researchers have found that Bimuno-galactooligosaccharides (B-GOS) – a second-generation prebiotic – may be able to help inhibit anxietyand therefore reduce stress reactivity in healthy subjects.

ProbioticsIn a small study, a kefir containing a Lactobacillus shirota casei strain prevented stress-related cortisolincreases and increased serotonin levels in stressed medical students.

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PostbioticsA recent study also suggests butyrate, a beneficial short-chain fatty acid (SFCA) produced by bacterialfermentation of fiber in the colon, may decrease chronic neuroinflammation in mice.

Cognitive health via gut health emerges as a functional benefitin recent patent filingsProbiotics to enhance memoryBattelle Memorial Institute and the University of California have a pending US patent publicationUS20180200312A1 describing the use of a mixture of probiotics for enhancing memory and/or reducingfear and/or pain. The probiotic mixture comprises viable cells of strain RF39 and family Lactobacillaceae.

Reducing anxiety in breast-fed infantsGroupe Danone has a PCT publication WO2016043583A1 claiming to reduce anxiety in a breast-fedinfant by administering fructooligosaccharides to the breastfeeding mother of the infant.Fructooligosaccharide is a non-digestible oligosaccharide that is partially digested in the intestine by theaction of acids or digestive enzymes present in the human upper digestive tract, and fermented by thehuman intestinal flora into organic acids, preferably into lactic acid, butyrate, propionate and/or acetate.

Source: Cipher

Step 4 Nutritious FormulaPowder (Vietnam) with 2-FL

HMO

Human milk olgiosaccharides move beyondinfant nutrition to support gut-brain axis

• Reckitt Benckiser (RB) has a patent pending (US2015/0305385A1) filedby Mead Johnson Nutrition (MJN), which RB acquired in 2017, for anutritional composition with ingredients including a human milkoligosaccharide (HMO) that "advantageously promotes the gut-brainaxis."

• Another MJN filing (US2018/0064739A1) is for compositions that"advantageously modify the gut microbiome and improve select markersof immunity, brain structure and gut function."

• Glycom has a PCT publication (WO2018215960A1) for the production ofa composition of HMOs, which could be useful for the treatment of gut-brain disorders such as autism, stress, anxiety and depression.

Source: Cipher

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Meet the expertStephanie Mattucci

Associate Director, Global Food Science

With 10 years of experience in the food industry, Stephanie brings a foodscience background to her work at Mintel. She is responsible foranalyzing and providing insight on ingredient and nutrition trends,regulations and food science innovations. She has a bachelor's degree inFood Science from the University of Wisconsin-Madison.

Read more by this expert | Get in touch

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