Supervisor : Prof. Dr.Hekma Coordinator : Ph.Fatmah
Bakhder
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Contents : Definition Trade and generic names Mechanism of
action Clinical use Side effects Drug interactions Life style
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Definition BP, defined as a repeatedly elevated blood pressure
exceeding 140 over 90 mmHg. a systoic pressure above 140 or a
diastolic pressure above 90
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Causes of hypertension Smoking Obesity Low physical activity
Salt diet alcohol intake
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Treatment of hypertension
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:Mechanism Of Action
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side effects
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Aliskiren had acceptable oral bioavailability and were clinical
enough for clinical uses, but it has some of side effects :
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Cardiovascular Cardiovascular side effects have included
extremely rare cases of hypotension (0.1%) and angioedema
(0.06%).
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Respiratory system In this research (Effects of modulators of
the renin-angiotensin- aldosterone system on cough), researcher
mentioned that there is a relation between patients with
uncomplicated primary hypertension with a history of ACE
inhibitor-related cough
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Nervous system N e r v o u s s y s t e m s i d e e f f e c t s
h a v e i n c l u d e d h e a d a c h e, d i z z i n e s s, f a t i
g u e, a n d s i n g l e e p i s o d e s o f t o n i c - c l o n i
c s e i z u r e s w i t h l o s s o f c o n s c i o u s n e s
s.
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Gastrointestinal system Inhibit renin release leading to
decrease of angiotensin II secretion, and that mean loss of higher
amount of water and sodium causing diarrhea. ( THE EFFECT OF
THERENIN-ANGIOTENSIN SYSTEM ON MUCOSAL WATER AND SODIUM TRANSFER IN
EVERTED SACS OF RAT JEJUNUMBy ANN D. CROCKER* AND KENNETH A.
MUNDAY)
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Dermatic Due to decrease of angiotensin release, vascular 'll
dilate and appear of redness & rash.
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Caution Drugs that act directly on the
renin-angiotensin-aldosterone (RAA) system can cause fetal and
neonatal morbidity and death when administered during
pregnancy.
Statements thats may increase the risk -Elderly-Dehydrated
-Kidney disease -Diabetes -Advanced heart failure -Regular or long
term use of NSAIDs use of NSAIDs
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Cyclosporines (Neoral) HMG CoA Reductase Inhibitors
(Atorvastatin) Itraconazole and Ketoconazole
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Cyclosporines HMG CoA Reductase Inhibitors P-gp Inhibitors
Thiazide Diuretics Aliskiren VS Hydreochlorothiazide
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Loop Diuretics Aliskiren VS Furosamide
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Muscle relaxant..
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SS O D I U M R E D U C T I O N EE X E R C I S E AA V O I D A L
C O H O L C O N S U M P T I O N DD I E T A R Y C H A N G E S WW E I
G H T L O S S SS M O K I N G C E S S A T I O N MM E D I T A T I O
N
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The recommended sodium intake is less than 6gms per day for all
patients with hypertension or prehypertension.
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Doing of exercise for 30 minutes on most days of the week is
help patients with prehypertension to reductions of 4 mm Hg in
systolic blood pressure and 3 mm Hg in diastolic blood
pressure.
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By following of DASH plane which is depend on fruits and
vegetables; high in low- fat dairy products, potassium, magnesium,
and calcium; and low in total saturated fats.
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Reduction of 10 lb can help reduce blood pressure or prevent
hypertension.
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In patients with hypertension, there is an increase in
cardiovascular events in those who smoke compared with those who do
not. So. decreasing smoking lead to reduce of blood pressure
clearly.
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Include Meditate on God's creatures in the universe, like the
sun, moon, birds, sunrise and sunset, all this help patients with
hypertension and any person to be quiet and closer to the God
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Done by : Ashwaq zahed Elaf Khalifa Bashier al ameer Bayan baz
Duaa ageel Shatha abed Lina aldawoo d Maeen medwahi Morooj almoald
Marwa barnawy Hadeel al- fahmi Yasmeen alsahafy
