SUPERFICIAL FUNGAL SUPERFICIAL FUNGAL INFECTION INFECTION

DERMATOPHYTOSISDERMATOPHYTOSIS

SUPERFICIAL FUNGAL SUPERFICIAL FUNGAL INFECTION INFECTION

DERMATOPHYTOSISDERMATOPHYTOSIS

THREE GENERA KNOWN TO CAUSE DISEASETHREE GENERA KNOWN TO CAUSE DISEASE-TRICOPHYTON-TRICOPHYTON- MICROSPORUM - MICROSPORUM - EPIDERMOPHYTON- EPIDERMOPHYTON

EPIDEMIOLOGY• GEOPHILIC - GEOPHILIC -

– M.GYPSEUM – M.GYPSEUM – M. FERRUGINEUM – M. FERRUGINEUM - T. TERRESTRE - T. TERRESTRE - T.VIOLACEUM - T.VIOLACEUM

• ZOOPHILIC -ZOOPHILIC - - M. CANIS – CAT, DOGS,SHEEPS - M. CANIS – CAT, DOGS,SHEEPS - T. EQUINUM – CATS, DOGS,CATTLES - T. EQUINUM – CATS, DOGS,CATTLES - T. VERRUCOSUM – CATS , DOGS, - T. VERRUCOSUM – CATS , DOGS, CATTLES,SHEEPSCATTLES,SHEEPS

• ANTHROPOPHILIC - ANTHROPOPHILIC - - -E. FLOCCOSUM E. FLOCCOSUM –M. AUDOUINII –M. AUDOUINII –T. MENTAGROPHYTES –T. MENTAGROPHYTES –T. RUBRUM –T. RUBRUM – T. – T. TONSURANS – TONSURANS –

PATHOGENESIS• FUNGI MUST OVER COME

- EFFECT OF UV LIGHT –TEMPERATURE VARIATION – COMPITION WITH NORMAL FLORA -FUNGISTATIC AGENTS –

• FATTY ACIDS,SPHINGOSINES • - EPIDERMAL GROWTH

• DTH IMMUNE RESPONSE

TINEA CAPITIS

ECTOTHRIX ENDOTHRIXYELLOW- GREEN FLUORESCENCE DULL GRAY-GREEN FLUORESCENCE

M.AUDOUINIIM.CANISM.FERRUGINEUM

T.SCHOENLEINII

NO FLUORESCENCE NO FLUORESCENCE

M.GYPSEUMT.MENTAGROPHYTEST. RUBRUM

T.TONSRANST. VIOLACEUM

ORGANISMS ASSOCIATED WITH ORGANISMS ASSOCIATED WITH CLINICAL TYPES OF TINEA CAPITISCLINICAL TYPES OF TINEA CAPITIS

INFLAMMATORYZOOPHILICGEOPHILIC

NONINFLAMMATORYANTHROPOPHLICECTOTHRIC

BLAK DOTANTHROPOPHILICENDOTHRIX

FAVUS

M.AUDOUINIIM. CANISM. GYPSEUMT.MENTAGROPHYTET.TONSURANST. VERRUCOSUM

M.AUDOUINIIM. CANISM.FERRUGINEUMT.TONSURANS

T.TONSURANST.VIOLACEUM

M.GYPSEUMT. SCHOENLEINIIT.VIOLACEUM

TINEA CAPITIS

TINEA CAPITIS

TINEA CAPITIS

BLACK DOT TINEA CAPITIS

INFLAMMATORY T. CAPITIS

TINEA BARBAE

• INFAMATORY TYPE- T. MENTAGROPHTE, T. VERRUCOSUM

• SUPERFICIAL TYPE - ANTHROPOPHILIC –T. VIOLACEUM,T.RUBRUM

• CIRCINATE TYPE

TINEA BARBAE

TINEA FACEII

TINEA FACEII

TINEA BARBE

TYPICAL TINEA CORPORIS

TINEA CORPORIS

INFLAMMATORY T. CORPORIS

TINEA CORPORIS

TINEA CORPORIS

TINEA CORPORIS

TINEA CORPORIS

TINEA UNGUIUM

TINEA UNGUIUM

TINEA UNGUIUM

TINEA MANUM

TINEA MANUM

TINEA MANUM

TINEA CRURIS

TINEA CRURIS

TINEA CRURIS

TINEA CRURIS

TINEA CRURIS

TINEA PEDIS• CHRONIC INTERTRIGINOUS TYPE• CHRONIC HYPERKERATOTIC TYPE• VESICULOBULLOUS TYPE• ACUTE ULCERATIVE TYPE

TINEA PEDIS

TINEA PEDIS

TINEA PEDIS

TINEA PEDIS

TINEA PEDIS

KOH MOUNT

ENDOTHRIX FUNGUS

ECTOTHRIX FUNGUS100X

TREATMENT

SYSTEMIC THERAPY

TOPICAL THREAPY **

SYSTEMIC ANTIFUNGALS

• ALLYLAMINS –

• INHIBITS SQUALENE EPOXIDASE BLOCKING BIOSYNTHESIS OF ERGOSTEROL

• FUNGICIDAL• 3 TO 6 mg/kg OD• CONTRAINDICATED IN PREGNANCY & LACTATION

• TRIAZOLES – ITRACONAZOLE, FLUCONAZOLE INHIBIT 14 alfa DEMETHYLASE ENZYME IN CELL

MEMBRANE USEFUL FOR CONVERSION OF SQUALENE TO ERGOSTEROL

.

IMIDAZOLE – KETOCONAZOLE

GRISEOFULVIN – DISRUPS MICROTUBULE MITOTIC SPINDLE FORMATON THUS ARREST MITOTIC AT METAPHASE STAGE

TREATMENT

TOPICAL -ALLYLAMINES – TERBINAFINE,NAFTIFINE -BENZYLAMINE - BUTENAFINE -IMIDAZOLES CLOTRIMAZOLE,

MICONAZOLE,KETOCONAZOLE

-TOLNAFTAE

THANK YOU….,