Subject Index

Absorbance Correlation Analysis (ACA) 74

activated complex 317 activation parameters 308, 316 activation energy 71

,negative 303 - , temperature dependence of 297

advancements of reaction steps 2, 7, 13

Al3+ 89 alkali ion, carrier 372

- , complex formation with macro­cyclic ligands 393 - , mechanism of complex forma­tion 391 - , specificity for 371, 386

- , stability constants of com-plexes 388

alkali metals 84, 88, 93 alkaline earths 84, 88 "all-or-none" transition 292, 293 allosteric mechanisms 23, 272, 327 a-chymotrypsin 296 amino acid 148 amplitude, relative 259

of relaxation 293, 294 anthranyloyl group (AN) 296, 298 antibiotics 372 - , cation selectivity 372 - ,membrane-bound 386 antibodies, heterogeneity 321 - , kinetic mapping of antibody

site 322, 324 - , subsites of interaction 324 antigen 306, 319 "approach cone" 313 Arrhenius plot 71 association step 307 autocorrelation 49, 252

function 73 average relaxation times

88, 104 89

24

Berryllium sulphate 70 bimolecular reaction 66, 331 binding, non-covalent 306 - , of ligands 253

site 273, 308 step 308

biochemical models 147 black lipid membrane 73 "bootstrapping" 276 Brownian motion, rotational 78, 221

-, rotational relaxation time 220, 227 - ,translational 222

bulge loop diffusion 209

Ca2+ 84, 85, 88, 104 Ca2+ complexes 407 calorimetric measurements 286, 287 canonical equations 259, 263 "carrier" 93 Cathode current 56 cation carriers, dynamic aspects 409

complex formation 375 specificity 404 transport, carrier-mediated 371 - , elementary steps 375

Cd2+ 104 ce3+ 104 cell for pH-measurements 291 cells for optical measurements 289 chain growth parameter 199

sliding mechanism 209 channels 73 chelation 88 chemi6al relaxation 307 chymotrypsinogen 282, 286, 293, 294,

295 A 283, 285

circular dichroism 386 13C_NMR 399, 404

Co2+ 85, 88, 100, 104 Co 3+ 104 Co(tren)2+ 103 cobalamins 103 codon-anticodon interaction 213

coenzyme 157 complex, non-covalent 308 computer acquisition 250

simulation 303 Concentration Correlation Analysis

(CCA) 43 concentration variables, i.ndependent

9 - , - , number of 3

conformational adaption 410 changes 93, 94 - , long range 327 - , restricted 327 equilibria 400 - , solvents dependence 401 fluctuation 288 rearrangement, kinetics of 378 transitions 331, 333, 385

convolution 263, 260 "cooling-jump" 294 cooperative model 199 coordination number 86, 87, 103 correlation computers 60

function 53 correlator 61 covalent modification 296 Cr2+ 104 cr 3+ 104 cross correlation 49 crown ether 95 cryptates 386 Cs+ 96 Cu2+ 95, 104 cytochrome c 282

data acquisition 250 denaturation 273 dielectric relaxation 151, 170 difference spectra, kinetic 294,

295 diffusion 51 - , coefficients 309 - , controlled processes 86, 88,

94, 312, 314, 316, 317, 356 - , rotational 78 - , translational coefficient 64 diffusional preequilibrium 312,

314, 316, 318 di-isopropylphosphoryl (DIP) 296,

298 dinactin 94, 95 dinitrophenyl 317 2,4-dinitrophenyl derivatives 322 dissipation 49 dissociative-interchange 87 DNA 66

415

DNA lattice 268 DNA structure 246 d-orbi tals 89 Dy3+ 104

eigenvalues 10, 11 eigenvectors 11 electric field jump 124, 170, 196,

375 electrolyte 70 elementary interactions 306, 308 encounter complex 308

step 308, 319 activation parameters of 313 enthalpy change of 313, 314 equilibrium constant of 309

energy profile 307, 316 enniatin B 389 enthalpy of activation 314, 334

reaction 258 entropy of activation 313, 334 enzyme-DNA interactions, models 268,

269, 270 Er3+ 104 Escherichia coli 245, 249 ethidium bromide 66, 220, 245, 247,

249, 254, 271 Eu3+ 104 exchange rate 7 excluded binding 258, 261

site 248, 271 volume 344 - , nonideality 366

exponential decays 251 sum 358

extensive parameters 44 extinction coefficients 5, 15 Eyring equation 313

88, 104 89, 104

method 169 flowing afterglow technique 115 fluctuation dissipation theorem 49 fluctuations 45 fluorescence 6, 249

quantum yield 219 stationary excitation 227 temperature jump 228, 229

instrumentation 228 fluorescence anisotropy, instrumenta­

tion 222 - , time dependence 221 correlation analysis (FCA) 54 probe 145

free energy change 285, 286 of activation 297, 313, 334

Fuoss equation 98, 99, 104

gaps 255 gas phase solvation 116 Gaussian beam 56 Gd3+ 104 GDH self assembly, kinetics of 357

- , thermodynamics of 343 Gramicidin A 73

haematoporphyrin IX 95 haemoglobin 104 hairpin helices 210 hap tens 307 helix coil transitions 191 heterogeneity, restricted 322 Ho3+ 104 horse-radish peroxidase 104 hydration energy 94 hydrogen bonded complex 107, 109,

143, 151 bonding 91, 97 bonds 93, 109, 114, 173, 317

hydrolysis 89 hydrophobic interactions 193, 317,

348 3-hydroxypyridine 132, 136, 156,

157

immunoglobulins 306, 331 information transfer 213 initiation 246 instrument drift 262 intercalating dye 253 intercalation 247 intermediates 300 internal conjugate-base mechanism

91, 92 rotation 93

ion condensation 196 pair 87, 107, 113, 141

ionic radius 90 ionophores 93 ISing model, three-dimensional 300 isodesmic model 192 isomerization 301

of peptide bonds 301

Jahn-Teller distortion 90

K+ 84, 93, 96, 104 kinetic mapping 325

416

"kinetic matrix" 8 kinetics of unfolding and refolding

292

La3+ 104 lanthanides 85, 104 lateral diffusion 64 lattices 253 Li+ 104 lifetime 105

of excited state 221 distribution of conforma­

tional dependence on Mg2+ 223, 225

distribution of conforma­tional states 221

ligand exchange mechanism ligand-lattice interaction ligand-protein association light scattering 5

392 256 333

lipid bilayer membranes, kinetic studies 373

Lu3+ 104 lysozyme 282

macrocyclic polyethers 386 macrocyclics 92, 94, 95 magnetic valves 291 manganese 101 mass conservation 9 mean relaxation time 359

square fluctuation 45 melting 301

curve 283 membranes 64, 68, 93, 95 metal ions 84 Mg2+ 84, 85, 88, 104 MIDAS 250 Mn2+ 85, 104 model systems 85 models 93 modified proteins 296, 298 "moddlating function" 252 monadtin 94, 95 monomolecular reaction 331 Monte-Carlo simulation 300 Mo03 (OH) - 104 MOPC 315 317 MOPC 460 331 multidentate ligands 92

complex formation with cations 394

myeloma 331 myoglobulin 104, 282

Na+ 84, 94, 95, 69, 104 Nd 3+ 104 NHt 96 Ni 2+ 86, 88, 90, 100, 104 Ni2+ 91 Ni'nren)2+ 103 nigericin 94, 95 noise, Johnson 71, 72 - , 1/ f 73 non-linear regression 263

analysis 223 normal modes 276 "normal reactions" 4, 13 nuclear magnetic resonance 108,

124, 127, 140, 146, 155, 169, 171

nucleation 204, 299, 300 parameter 199

nucleic acids 191 nucleotide base, recognition of

191 - , stacking of 192

occupation number fluctuations 44, 52

optical absorption 15 Orientation Correlation Analysis

(OCA) 78 orientation factor 313 outer-sphere complex 87, 88, 90,

91, 98

photodegradation 75 poly [d (A-T)] 245, 246, 249 polyelectrolyte 196 polymer distribution of GDH 348 polypeptides 163 porphyrin 96 potential curve 114 Pr 3+ 104 pressure 285

dependence 284, 287 jump 128, 170

protein folding 282 unfolding 282

protein-nucleic acid interactions 245

proteins 163 proton affinity 108

carrier 375 transfer 99, 375 - , kinetics of 378 transport 375 tunnelling 120, 146

proton, intermolecular transfer 123, 127, 148, 155

417

proton, intramolecular transfer 129, 148, 150, 155, 163

purines 150, 155 pyrimidines 150, 155 pyroxidase-5'-phosphat 157

quantum mechanical calculations 114 quasi-eleastic light scattering (QELS)

54, 76

random association model 361 rate constants 308

apparent 20 - , ~or refolding 296 - , for unfolding 296 equations 8

rate-limiting step 316 Rb+ 96, 104 reaction step 16, 22 reactions, thermodynamically inde-

pendent 3, 9 recognition 245 redox reactions 85 refractive index 76 relaxation amplitudes

231, 232, 257, 293, equations 3, 8 experiments 255 function 3

3, 17, 26, 294

methods 108, 121, 169 spectra, simulation of 359 spectrum 331 time 3, 11, 17, 26, 231, 257, 258, 293, 296 - , analog simulation 229

reporter molecule 247 Resistance Correlation Analysis (RCA)

68 rhodamine 65 ribonuclease ring-closure ring systems RNA polymerase

265

282 91, 98 103, 105

245, 246, 247, 249,

- , binding site 269, 273

scattered light, angular dependence of 351 - , detection in chemical relaxa­tion experiments 353 - , relaxation amplitudes 354

sequential model 299, 358 "shot-noise" 59 Sm3+ 104

small molecules 287, 288 SN1 86, 87, 88 SN2 87, 88 solid angle of approach 312 solvation 287, 301

sphere 308 by water 287

specific heat 284, 287, 288, 303 spectrum analyzer 62, 72 Sr2+ 88, 104 "staggering zipper model" 200 Stapholoaoaaus nuclease 282 static signals 364 stationary state approximation 312 steady-state assumptions 17, 20

rates 299 steric 98

factor 105 hindrance 93, 97 interaction 103

stoichiometric coefficient 2, 9, 13 stopped flow method 144, 169, 307 strength of perturbation 2, 8 substitution 84

Tb 3+ 104 temperature jump 67, 125, 128, 136,

144, 156, 160, 168, 169, 249 by cable discharge 196

- , relaxation experiments 378 - ,"slow-T-jump" 290, 292

ternary complex 97, 103 complexes 105 formation 99

tetravalent ions 89 thermodynamic matrix 8

nonideality 344, 353 titrations, spectrophotometric 387 Tl+ 96 Tm3+ 104 tobacco mosaic virus 79 "total signal" 250 transcription 245 transfer RNA, anticodon loop 227

- , chemical relaxation experi­ments, stopped flow 231 - , chemical relaxation experi­ments, T-jump 231 - , conformational states in solution, 223, 226 - , cooperative interactions with Mg2+ 233, 238

crystal structure 227 - ,D-loop 219, 220 - , fluorescent probes for solution structure 219, 220

418

transfer RNA, interaction with amino­acyl-tRNA-synthetase 239 - , interaction with elongation factor Tu 239 - , interaction with spermine 239 - , model for allosteric confor-mations 233 - , primary sequence 220 - , rates of conformational transi-tions 233, 236 - , recognition of 239 - ,T~CG-loop 239

transformation matrix 10 transition effects 294, 297

elements 90 trinactin 94, 95 2,4,6-trinitrophenyl derivatives 322 trypsin 282

inhibitor 282 turbidity correlation analysis (TCA)

76

ultrasound absorption 125, 128 136, 148, 151, 157, 162, 170, 193, 391

UV-absorption spectroscopy 377

V2+ 104 valinomycin 93, 95, 372 - , complex formation 409 - ,membrane-bound 409 valinomycin-K+ complex 396 valinomycin-Na+ complex 391 van't Hoff analysis 284, 285, 287

enthalpy 286 plots, nonlinear 283

vapor phase 107, 108, 115 virginiamycin S 372 virial coe.fficients 353 v02+ 104

water-exchange 88, 89, 99, 104 Wiener-Khinchin theorem 53

zinc 101, 102 Zn2+ 85, 105 Zn(dien)2+ 103

Molecular Biology, Vol. 10: R.J. Lukens Vol. 18: H. Kersten, W. Kersten

Biochemistry Chemistry of Fungicidal Inhibitors of Nucleic Acid Action Synthesis

and Biophysics 8 fIgures. XIII, 136 pages. 1971 Biophysical and Biochemical ISBN 3-540-05405-7 Aspects

Editors: 73 fIgures. IX, 184 pages. 1974

V91. 11: P. Reeves ISBN 3-540-06825-2

A. Kleinzeller The Bacteriocins G.F. Springer 9 fIgures. XI, 142 pages. 1972 Vol. 19: M.B. Mathews

H.G. Wittmann ISBN 3-540-05735-8 Connective Tissue Macromolecular Structure and Evolution

Vol. 12: T. Ando, M. Yamasaki, 31 llgUIes. XII, 318 pages. 1975 Vol. 1: J.H. van'tHoff K. Suzuki ISBN 3-540-07068-0 Imagination in Science Protamines Translated into English with Isolation, Characterization, notes and a general introduction Structure and Function Vol. 20: M.A. Lauffer

by G.F. Springer 24 llgUIes, 17 tables. Entropy-D"riven Processes

1 portrait. VI, 18 pages, 1967 IX, 114 pages. 1973 in Biology

ISBN 3-540-03933-3 ISBN 3-540-06221-1 Polymerization of Tobacco Mosaic Virus Protein and

Vol. 2: K. Freudenberg, Vol. 13: P. Jones, A. Paraf Similar Reactions

A.C. Neish 90 llgUIes. X, 264 pages. 1975

Constitution and Biosyn-Chemical and Biological ISBN 3-540-06933-X

thesis of Lignin Basis of Adjlivants

10 llgUIes. IX, 129 pages. 1968 24 llgUIes, 41 tables. VIII, 153 pages. 1973 Vol. 21: R.C. Bums,

ISBN 3-540-04274-1 ISBN 3-540-06308-0 R.W.F. Hardy

Vol. 3: T. Robinson Nitrogen Fixation in Bacteria

The Biochemistry of and Higher Plants

Alkaloids Vol. 14: Micromethods 27 llgUIes. X, 189 pages. 1975

37 figures. X, 149 pages.1968 in Molecular Biology ISBN 3-540-07192-X

ISBN 3-540-04275-X Edited by V. Neuhoff 275 figures (2 in color), 23 tables. XV, 428 pages. 1973 Vol. 22: H.J. Fromm

Vol. 5: B. Jirgensons ISBN 3-540-6319-6 Initial Rate Enzyme Optical Activity of Proteins Kinetics and Other Macromolecules 88 figures, 19 tables. 2nd revised and enlarged edition Vol. 15: M. Weissbluth X. 321 pages. 1975 71 llgUIes. IX, 199 pages. 1973 Hemoglobin ISBN 3-540-07375-2 ISBN 3-540-06340-4 Cooperativity and Electronic

Properties Vol. 23: M. Luckner, L. Nover, Vol. 6: F. Egami, K. Nakarhura 50 lIgUres. VIII, 175 pages. 1974

Microbial Ribonucleases ISBN 3-540-06582-2 H. Bohm

5 llgUIes. IX, 90 pages. 1969 Secondary Metabolism

ISBN 3-540-04657-7 and Cell Differentiation

Vol. 16: S. Shulman 52 figures, 6 tables.

Vol. 8: Protein Sequence Tissue Specificity and VI, 130 pages. 1977

Determination Autoimmunity ISBN 3-540-08081-3

A Sourcebook of Methods 32 figures. XI, 196 pages. 1974 and Techniques ISBN 3-540-06563-6 Edited by S.B. Needleman 2nd revised and enlarged edition 80 llgUIes. XVIII, 393 pages. Vol. 17: Y.A. Vinnikov 1975 Sensory Reception ISBN 3-540-07256-X Cytology, Molecular Mechanisms

and Evolution Springer-Verlag Vol. 9: R. Grubb Translated from the Russian

The Genetic Markers of By W.L. Gray and B.M. Crook Berlin Human Immunogiobins 124 figures (173 separate illus- Heidelberg 8 fIgures, XII, 152 pages. 1970 trations). IX, 392 pages. 1974 ISBN 3-540-05211-9 ISBN 3-540-06674-8 New York

Proceedings in Life Sciences

Metabolic Interconversion of Enzymes 1975

Fourth International Symposium Held in Arad, April 27th - May 2nd, 1975 Editor: S. Shaltiel 147 figures, 66 tables, XVII, 234 pages. 1976, ISBN 3-540-07888-6

The fITst international symposium in this field took place in 1970 and since then it has been re­peated at regular intervals. Particular subjects are the cascade system in charge of glycogen metabo­lism and its regulation; the role of hormones, CAMP protein kinase and phosphates in systems of interconversion; the use of chemical and physi­cochemical probes in the architecture of intercon­vertible enzymes; the assembly, function and re­gulation of the pyruvate dehydrogenase multien­zyme system. Also discussed are adenylation, ADP-ribosylation in glutamine metabolism, in the function of bacteria toxins, of mitochondria, and during T-phage infections; the use of specific pro­teolysis as a regulatory device. In situ vs in vitro studies are compared and unusual modulations of enzyme action and their possible function in age­ing cells are investigated.

Modem Methods in Forest Genetics

Editor: J.P. Miksche. With contributions by numerous experts 38 figures. XVI, 288 pages. 1976 ISBN 3-540-07708-1

Contributions by specialists in their respective fields cover modern techniques applicable to forest genetics and breeding. Among the subjects discussed and, where possible, demonstrated in laboratory procedures, are the biochemical char­acterization and microspectrophotometric mea­surement of nucleic acids, amino acids, proteins and enzymes, their extraction and assay using electrophoresis and thin layer chromatographs in the perspective of the interpretation of genetic variation and relatedness. Further chapters treat photosynthetic efficiency in the production of carbohydrate polymers and the determination of resin derivatives and phenolics as related to inher­itance, genetic considerations, with protocols for mineral analysis, and the impact of air pollution on forest trees. Also presented are indirect selec­tion, pollination techniques, protoplast fusion, and hormone flowering manipulation procedures.

Neural Principles in Vision

Editors: F. Zettler, R. Weiler 293 figures. X, 430 pages. 1976 ISBN 3-540-07839-8

This volume is the result of a symposium held at the University of Munich in 1975. It summarizes the most recent results of physiological analysis

and the anatomical investigations upon which they are based, and thus reflects the current state of visual neurophysiology. The contributions are intentionally limited to the peripheral part of the visual system, thus providing an opportunity to explore the common principles underlying recent discoveries concerning the retinas of vertebrates, arthropods and molluscs. It is of special value to all working in the fields of neurobiology, neuro­anatomy, sensory physiology and ophthalmology.

Radiation and Cellular Control Processes

Editor: J. Kiefer 17p figures. XIV, 321 pages. 1976 ISBN 3-540-07878-9

The book contains the complete and carefully edited papers of a conference held in October 1975 at the Strahlenzentrum, Giej),en (Fed. Rep. of Germany). The main emphasis is placed on eucaryotes. The central theme being - though not exclusively - "simple systems" (yeasts, algae, slime mould). The material was divided into the following sections: biochemical key processes, phenomena of repair and recovery, cell division and progression. Each section contains an explan­atory introduction (Authors: 1.M. Boyle, A.R. Lehmann, W. Sachsenmaier), and a further general paper by T. Alper deals with modern trends in ra­diobiology. As the participants of the conference deliberately chose not to be limited solely to ra­diobiology, the range of materials covers not only radiation-induced processes, but attempts to elu­cidate general principles of intercellular regulatory processes by means of a study of radiation effects, of both UV and ion irradiation.

Biochemistry of Membrane Transport

FEBS-Symposium No. 42 Editors: G. Semenza, E. Carafoli 414 figures, 76 tables. Approx. 740 pages. 1977. ISBN 3-540-08082-1 In preparation

This book contains 47 articles, dealing with vari­ous aspects of the topic Biochemistry of Mem­brane Transport. The area covered spans the mo­lecular architecture of biological membranes and the interaction of membrane lipids and proteins, the chemistry of ionophoric molecules and vari­ous theoretical aspects of transport processes, with a detailed discussion on the properties of several natural and reconstituted transport pro­cesses': - Distinctive for the book is its inter dis­ciplinajry character, a quality frequently found in membrane transport research. A further charac­teristics is the balance between established know­ledge, offered in some review-type articles and the numerous contributions presenting the most recent advances in the field.

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