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PUBLIC HEALTH INITIATIVES

AND THEIR NUTRITIONAL

MANAGEMENT

An evidence-based approach

Stephen Holt, M.D.

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Module 1

DSHEA Overview

Module 2Concepts of a Line

Module 3Condition-Specific Product Review

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Module 1: DSHEA

- DSHEA 1994

- Defines Supplement

- Limited Claims

- Good Scientific Agreement

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Module 1: Claims

- Limited to body structure and function

- No Treatment or prevention claims

- What is a disease

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Module 1: Product Information

Third party literature

Geographic separation

Truthful

Scientific literature

Resources

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Module 2: Condition Specific

Not A Disease

A Condition

Consumer Thoughts of Health

Initiatives

Focus On Target Audience

Spotting Targets

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Module 2: Physician Endorsed

Safety

Scientific Platform

Efficacy

Evidence-based

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Module 2: Synergy

Definition: Interaction of agents suchthat the total effect is greater than the

sum of the individual effects

Single Agents: Pass

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Module 2: Cascade of Events

Waterfall Concept

Sleep

Immunity

Inflammation

Single Agent Cannot Work

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Module 2: Synergistic Supplements

1 + 2 + 3 + 4

Compatible Mix

Different Areas Of The Cascade OfEvents

e.g. Immunity, Sleep, etc.

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THE PRODUCTS AND CONDITIONS

Cardiovascular Health

Brain Function

Digestive Health Sleep Function

Multiple Benefits

Skin Health

Menopause PMS

Bone and Joint

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CARDIOVASCULAR HEALTH

Cardiovascular Disease:

Number 1 cause of death

Major economic category e.g. Lipitor,

11 Billion dollars

Stalin drugs OTC?

Safety, Efficacy?

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An Overview Of Blood Fats And Cholesterol

LDL, VLDL, TG, HDL

Many agents lower LDL or

TG, some increase HDL

Lower LDL, VLDL, TG

Increase HDL

Oxidized cholesterol: Danger

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POPULAR CVS INGREDIENTS

Policosanol: plant waxes,breakdown LDL,antioxidants, inhibit clotting, clinical outcome

Oat Beta Glucan: approved CVS risk reductionclaim

Phytosterols: inhibition cholesterol absorption

Red Yeast Rice: mevinolin blocks HMG CoAreductase

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Blood Homocysteine Elevation

Independent risk factor CVS disease

Lower by B6, B12, Folate

Association other diseases

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BRAIN FUNCTION

Poor cognitive function

Risks: diet, CVS, stress

Lifestyle and Nutrition

Sleep, exercise, mental gymnastics

Psychonutrition

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PSYCHONUTRITION

Calorie intake

Omega-3 fatty acids (EPA, DHA)

Antioxidants

Specific nutrients

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CNS SUPPORTING SUBSTANCES

Brain specific nutrients

Phospholipids

Acetyl L Carnitine

Vinpocetine

L Alphaglycerylphosphorylcholine

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The Power Of Phospholipids

Phospatidylserine: clinical trials, memoryimprovement, cognitive skills

Phosphatidylcholine: movement disorders,decreased agitation, memory

Phosphatidylinositol: anxiolytic, antidepressant

Phosphatidylthemolamine: similar benefit

SUPPORTS CELL MEMBRANE STRUCTURE

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Acetyl-L-Carnitine

Energy conversion enhance

Mitochondrial effect

Neurotransmitter synthesis

Antiaging, enhances blood flow,

neuropathy

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Vinopocetine

Preiwinkle Plants (Vinca)

Drug in Europe and Japan

Increases blood flow

Antioxidant

Blood vessel dialator

CVS-based dementia improved

Motion sickness, sight, hearing

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Alpha-GPC

Lecithin dreived L-alpha-glycerylphosph-

orylcholine

Increase acetylcholine

Growth hormone enhancer

Benefit in cognitive decline

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ENZYME NUTRITION

Many plant-based enzymes

Amylase, protease, lipase, cellulase,lactase, hemicellulase, chlorophyll,barley grass, etc.

Natural vegetarian help?

Enhanced nutrition through absorption

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NUTRITIONAL SUPPORT FOR SLEEP

THE SLEEP NA

TURALLY PLAN

Cascade effect

Herbal blend, valerian, hops, chammomille,lemon balm

Melatonin, small dosage

5-HTP

B Vitamins

Magnesium pulse

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SKIN SUPPORT

HEALTH AND BEAUTY FROM WITHIN!

COSMECEUTICALS

Largest organ

Antioxidants: alpha lipoic acid,vitamins C,E, grape seed extract,omega-3 fatty acids

Silicon, calcium

Hyaluronic acid

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THE METABOLIC SYNDROME X

The metabolic syndrome

Variable combination of obesity, BP,cholesterol, linked by insulin resistance

70 million Americans

80% supplement purchases

The future of the industry

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